金 永輝

最終更新日時: 2021/08/25 09:47:39

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氏名(漢字/フリガナ/アルファベット表記)
金 永輝/キン エイキ/Jin, Yonghui
所属部署・職名(部局/所属/講座等/職名)
ウイルス・再生医科学研究所/再生組織構築研究部門/助教
協力講座
部局 所属 講座等 職名
医学研究科 医学専攻 組織再生応用/分化誘導研究 助教
医学研究科 医科学専攻 組織再生応用/分化誘導研究 助教
プロフィール
(日本語)
臨床応用を目指した基礎研究を行っている。基礎医学研究の成果を社会に還元することで、患者が従来の治療法より効果がよく、副作用が低い新規治療法を受けることができる。
(英語)
I am conducting the basic research aimed at clinical application. By returning the results of fundamental medical research to society, patients can receive a novel therapy which is more effective and has lower side effects than conventional treatments.
使用言語
言語名(japanese) 言語名(english) コード
英語 English eng
中国語 Chinese zho
日本語 Japanese jpn
researchmap URL
https://researchmap.jp/7000010625
研究テーマ
(日本語)
難治疾患の病理学的機構を解明すると共に、新規治療法を開発する。
(英語)
Elucidating the pathological mechanism and developing new therapies of intractable diseases.
研究概要
(日本語)
患者さん由来細胞からiPS細胞を樹立した後、特定な細胞に分化させ、難治疾患を体外で再現することで、病理的機構を解明する。この疾患iPS細胞を使ったモデルを用いて、新規治療法の開発に取り込んでいる。
(英語)
The established iPS cells from the patient-derived cells was differentiated into specific cell lineage. Using this type of cells, we recaptured and elucidated the pathological mechanism. We are working on the development of novel therapies with this disease model.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
幹細胞生物学 Stem cell biology
腫瘍学 Oncology
整形外科学 Orthopaedics
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Kawai S, Yoshitomi H, Sunaga J, Alev C, Nagata S, Nishio M, Hada M, Koyama Y, Uemura M, Sekiguchi K, Maekawa H, Ikeya M, Tamaki S, Jin Y, Harada Y, Fukiage K, Adachi T, Matsuda S, Toguchida J Kawai S, Yoshitomi H, Sunaga J, Alev C, Nagata S, Nishio M, Hada M, Koyama Y, Uemura M, Sekiguchi K, Maekawa H, Ikeya M, Tamaki S, Jin Y, Harada Y, Fukiage K, Adachi T, Matsuda S, Toguchida J Kawai S, Yoshitomi H, Sunaga J, Alev C, Nagata S, Nishio M, Hada M, Koyama Y, Uemura M, Sekiguchi K, Maekawa H, Ikeya M, Tamaki S, Jin Y, Harada Y, Fukiage K, Adachi T, Matsuda S, Toguchida J In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes. In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes. In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes. Nat Biomed Eng, 3, 7, 558-570 Nat Biomed Eng, 3, 7, 558-570 Nat Biomed Eng, 3, 7, 558-570 2019/07 英語 公開
Hino K, Horigome K, Nishio M, Komura S, Nagata S, Zhao C, Jin Y, Kawakami K, Yamada Y, Ohta A, Toguchida J, Ikeya M Hino K, Horigome K, Nishio M, Komura S, Nagata S, Zhao C, Jin Y, Kawakami K, Yamada Y, Ohta A, Toguchida J, Ikeya M Yonghui Jin Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva The Journal of Clinical Investigation, 127, 9, 3339-3352 The Journal of Clinical Investigation, 127, 9, 3339-3352 The Journal of Clinical Investigation, 127, 9, 3339-3352 2017/09 英語 研究論文(学術雑誌) 公開
Sakura Tamaki, Makoto Fukuta, Kazuya Sekiguchi, Yonghui Jin, Sanae Nagata, Kazuo Hayakawa, Sho Hineno, Takeshi Okamoto, Makoto Watanabe, Knut Woltjen, Makoto Ikeya, Tomohisa Kato, Junya Toguchida Sakura Tamaki, Makoto Fukuta, Kazuya Sekiguchi, Yonghui Jin, Sanae Nagata, Kazuo Hayakawa, Sho Hineno, Takeshi Okamoto, Makoto Watanabe, Knut Woltjen, Makoto Ikeya, Tomohisa Kato, Junya Toguchida Sakura Tamaki, Makoto Fukuta, Kazuya Sekiguchi, Yonghui Jin, Sanae Nagata, Kazuo Hayakawa, Sho Hineno, Takeshi Okamoto, Makoto Watanabe, Knut Woltjen, Makoto Ikeya, Tomohisa Kato, Junya Toguchida SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier PLOS ONE, 10, 11, e0142991 PLOS ONE, 10, 11, e0142991 PLOS ONE, 10, 11, e0142991 2015/11 英語 研究論文(学術雑誌) 公開
Yonghui Jin, Hassan Elalaf, Makoto Watanabe, Sakura Tamaki, Sho Hineno, Kazuhito Matsunaga, Knut Woltjen, Yukiko Kobayashi, Sanae Nagata, Makoto Ikeya, Tomohisa Kato, Takeshi Okamoto, Shuichi Matsuda, Junya Toguchida Yonghui Jin, Hassan Elalaf, Makoto Watanabe, Sakura Tamaki, Sho Hineno, Kazuhito Matsunaga, Knut Woltjen, Yukiko Kobayashi, Sanae Nagata, Makoto Ikeya, Tomohisa Kato, Takeshi Okamoto, Shuichi Matsuda, Junya Toguchida Yonghui Jin, Hassan Elalaf, Makoto Watanabe, Sakura Tamaki, Sho Hineno, Kazuhito Matsunaga, Knut Woltjen, Yukiko Kobayashi, Sanae Nagata, Makoto Ikeya, Tomohisa Kato, Takeshi Okamoto, Shuichi Matsuda, Junya Toguchida Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes PLOS ONE, 10, 7, e0131998 PLOS ONE, 10, 7, e0131998 PLOS ONE, 10, 7, e0131998 2015/07 英語 研究論文(学術雑誌) 公開
Ryo Takahashi, Satoshi Nagayama, Moritoshi Furu, Yoichiro Kajita, YongHui Jin, Tomohisa Kato, Seiya Imoto, Yoshiharu Sakai, Junya Toguchida Ryo Takahashi, Satoshi Nagayama, Moritoshi Furu, Yoichiro Kajita, YongHui Jin, Tomohisa Kato, Seiya Imoto, Yoshiharu Sakai, Junya Toguchida Ryo Takahashi, Satoshi Nagayama, Moritoshi Furu, Yoichiro Kajita, YongHui Jin, Tomohisa Kato, Seiya Imoto, Yoshiharu Sakai, Junya Toguchida AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers CANCER MEDICINE, 3, 4, 759-774 CANCER MEDICINE, 3, 4, 759-774 CANCER MEDICINE, 3, 4, 759-774 2014/08 英語 研究論文(学術雑誌) 公開
Akira Nasu, Makoto Ikeya, Takuya Yamamoto, Akira Watanabe, Yonghui Jin, Yoshihisa Matsumoto, Kazuo Hayakawa, Naoki Amano, Shingo Sato, Kenji Osafune, Tomoki Aoyama, Takashi Nakamura, Tomohisa Kato, Junya Toguchida Akira Nasu, Makoto Ikeya, Takuya Yamamoto, Akira Watanabe, Yonghui Jin, Yoshihisa Matsumoto, Kazuo Hayakawa, Naoki Amano, Shingo Sato, Kenji Osafune, Tomoki Aoyama, Takashi Nakamura, Tomohisa Kato, Junya Toguchida Akira Nasu, Makoto Ikeya, Takuya Yamamoto, Akira Watanabe, Yonghui Jin, Yoshihisa Matsumoto, Kazuo Hayakawa, Naoki Amano, Shingo Sato, Kenji Osafune, Tomoki Aoyama, Takashi Nakamura, Tomohisa Kato, Junya Toguchida Genetically Matched Human iPS Cells Reveal that Propensity for Cartilage and Bone Differentiation Differs with Clones, not Cell Type of Origin Genetically Matched Human iPS Cells Reveal that Propensity for Cartilage and Bone Differentiation Differs with Clones, not Cell Type of Origin Genetically Matched Human iPS Cells Reveal that Propensity for Cartilage and Bone Differentiation Differs with Clones, not Cell Type of Origin PLOS ONE, 8, 1, e53771 PLOS ONE, 8, 1, e53771 PLOS ONE, 8, 1, e53771 2013/01 英語 研究論文(学術雑誌) 公開
Hiroto Mitsui, Tomoki Aoyama, Moritoshi Furu, Kinya Ito, Yonghui Jin, Takayuki Maruyama, Toshiya Kanaji, Shinsei Fujimura, Hikaru Sugihara, Akio Nishiura, Takanobu Otsuka, Takashi Nakamura, Junya Toguchida Hiroto Mitsui, Tomoki Aoyama, Moritoshi Furu, Kinya Ito, Yonghui Jin, Takayuki Maruyama, Toshiya Kanaji, Shinsei Fujimura, Hikaru Sugihara, Akio Nishiura, Takanobu Otsuka, Takashi Nakamura, Junya Toguchida Hiroto Mitsui, Tomoki Aoyama, Moritoshi Furu, Kinya Ito, Yonghui Jin, Takayuki Maruyama, Toshiya Kanaji, Shinsei Fujimura, Hikaru Sugihara, Akio Nishiura, Takanobu Otsuka, Takashi Nakamura, Junya Toguchida Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability ARTHRITIS RESEARCH & THERAPY, 13, 5, R146 ARTHRITIS RESEARCH & THERAPY, 13, 5, R146 ARTHRITIS RESEARCH & THERAPY, 13, 5, R146 2011 英語 研究論文(学術雑誌) 公開
Tomoki Aoyama, Takeshi Okamoto, Kenichi Fukiage, Seiji Otsuka, Moritoshi Furu, Kinya Ito, Yonghui Jin, Michiko Ueda, Satoshi Nagayama, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida Tomoki Aoyama, Takeshi Okamoto, Kenichi Fukiage, Seiji Otsuka, Moritoshi Furu, Kinya Ito, Yonghui Jin, Michiko Ueda, Satoshi Nagayama, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida Tomoki Aoyama, Takeshi Okamoto, Kenichi Fukiage, Seiji Otsuka, Moritoshi Furu, Kinya Ito, Yonghui Jin, Michiko Ueda, Satoshi Nagayama, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida Histone Modifiers, YY1 and p300, Regulate the Expression of Cartilage-specific Gene, Chondromodulin-I, in Mesenchymal Stem Cells Histone Modifiers, YY1 and p300, Regulate the Expression of Cartilage-specific Gene, Chondromodulin-I, in Mesenchymal Stem Cells Histone Modifiers, YY1 and p300, Regulate the Expression of Cartilage-specific Gene, Chondromodulin-I, in Mesenchymal Stem Cells JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 39, 29842-29850 JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 39, 29842-29850 JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 39, 29842-29850 2010/09 英語 研究論文(学術雑誌) 公開
Kinya Ito, Tomoki Aoyama, Kenichi Fukiage, Seiji Otsuka, Moritoshi Furu, Yonghui Jin, Akira Nasu, Michiko Ueda, Yasunari Kasai, Eishi Ashihara, Shinya Kimura, Taira Maekawa, Akira Kobayashi, Shinya Yoshida, Hideo Niwa, Takanobu Otsuka, Takashi Nakamura, Junya Toguchida Kinya Ito, Tomoki Aoyama, Kenichi Fukiage, Seiji Otsuka, Moritoshi Furu, Yonghui Jin, Akira Nasu, Michiko Ueda, Yasunari Kasai, Eishi Ashihara, Shinya Kimura, Taira Maekawa, Akira Kobayashi, Shinya Yoshida, Hideo Niwa, Takanobu Otsuka, Takashi Nakamura, Junya Toguchida Kinya Ito, Tomoki Aoyama, Kenichi Fukiage, Seiji Otsuka, Moritoshi Furu, Yonghui Jin, Akira Nasu, Michiko Ueda, Yasunari Kasai, Eishi Ashihara, Shinya Kimura, Taira Maekawa, Akira Kobayashi, Shinya Yoshida, Hideo Niwa, Takanobu Otsuka, Takashi Nakamura, Junya Toguchida A Novel Method to Isolate Mesenchymal Stem Cells from Bone Marrow in a Closed System Using a Device Made by Nonwoven Fabric A Novel Method to Isolate Mesenchymal Stem Cells from Bone Marrow in a Closed System Using a Device Made by Nonwoven Fabric A Novel Method to Isolate Mesenchymal Stem Cells from Bone Marrow in a Closed System Using a Device Made by Nonwoven Fabric TISSUE ENGINEERING PART C-METHODS, 16, 1, 81-91 TISSUE ENGINEERING PART C-METHODS, 16, 1, 81-91 TISSUE ENGINEERING PART C-METHODS, 16, 1, 81-91 2010/02 英語 研究論文(学術雑誌) 公開
Yonghui Jin, Tomohisa Kato, Moritoshi Furu, Akira Nasu, Yoichiro Kajita, Hiroto Mitsui, Michiko Ueda, Tomoki Aoyama, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida Yonghui Jin, Tomohisa Kato, Moritoshi Furu, Akira Nasu, Yoichiro Kajita, Hiroto Mitsui, Michiko Ueda, Tomoki Aoyama, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida Yonghui Jin, Tomohisa Kato, Moritoshi Furu, Akira Nasu, Yoichiro Kajita, Hiroto Mitsui, Michiko Ueda, Tomoki Aoyama, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida Mesenchymal stem cells cultured under hypoxia escape from senescence via down-regulation of p16 and extracellular signal regulated kinase Mesenchymal stem cells cultured under hypoxia escape from senescence via down-regulation of p16 and extracellular signal regulated kinase Mesenchymal stem cells cultured under hypoxia escape from senescence via down-regulation of p16 and extracellular signal regulated kinase BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 391, 3, 1471-1476 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 391, 3, 1471-1476 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 391, 3, 1471-1476 2010/01 英語 研究論文(学術雑誌) 公開
Yonghui Jin, Yasuko Shima, Moritoshi Furu, Tomoki Aoyama, Takeharu Nakamata, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida Yonghui Jin, Yasuko Shima, Moritoshi Furu, Tomoki Aoyama, Takeharu Nakamata, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida Yonghui Jin, Yasuko Shima, Moritoshi Furu, Tomoki Aoyama, Takeharu Nakamata, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida Absence of Oncogenic Mutations of RAS Family Genes in Soft Tissue Sarcomas of 100 Japanese Patients Absence of Oncogenic Mutations of RAS Family Genes in Soft Tissue Sarcomas of 100 Japanese Patients Absence of Oncogenic Mutations of RAS Family Genes in Soft Tissue Sarcomas of 100 Japanese Patients ANTICANCER RESEARCH, 30, 1, 245-251 ANTICANCER RESEARCH, 30, 1, 245-251 ANTICANCER RESEARCH, 30, 1, 245-251 2010/01 英語 研究論文(学術雑誌) 公開
Tomoki Aoyama, Takeshi Okamoto, Yoshiki Kohno, Kenichi Fukiage, Seiji Otsuka, Moritoshi Furu, Kinya Ito, Yonghui Jin, Satoshi Nagayama, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida Tomoki Aoyama, Takeshi Okamoto, Yoshiki Kohno, Kenichi Fukiage, Seiji Otsuka, Moritoshi Furu, Kinya Ito, Yonghui Jin, Satoshi Nagayama, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida Tomoki Aoyama, Takeshi Okamoto, Yoshiki Kohno, Kenichi Fukiage, Seiji Otsuka, Moritoshi Furu, Kinya Ito, Yonghui Jin, Satoshi Nagayama, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida Cell-specific epigenetic regulation of ChM-I gene expression: Crosstalk between DNA methylation and histone acetylation Cell-specific epigenetic regulation of ChM-I gene expression: Crosstalk between DNA methylation and histone acetylation Cell-specific epigenetic regulation of ChM-I gene expression: Crosstalk between DNA methylation and histone acetylation BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 365, 1, 124-130 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 365, 1, 124-130 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 365, 1, 124-130 2008/01 英語 研究論文(学術雑誌) 公開
Kenichi Fukiage, Tomoki Aoyama, Kotaro R. Shibata, Seiji Otsuka, Moritoshi Furu, Yoshiki Kohno, Kinya Ito, Yonghui Jin, Satoshi Fujita, Shunsuke Fujibayashi, Masashi Neo, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida Kenichi Fukiage, Tomoki Aoyama, Kotaro R. Shibata, Seiji Otsuka, Moritoshi Furu, Yoshiki Kohno, Kinya Ito, Yonghui Jin, Satoshi Fujita, Shunsuke Fujibayashi, Masashi Neo, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida Kenichi Fukiage, Tomoki Aoyama, Kotaro R. Shibata, Seiji Otsuka, Moritoshi Furu, Yoshiki Kohno, Kinya Ito, Yonghui Jin, Satoshi Fujita, Shunsuke Fujibayashi, Masashi Neo, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida Expression of vascular cell adhesion molecule-1 indicates the differentiation potential of human bone marrow stromal cells Expression of vascular cell adhesion molecule-1 indicates the differentiation potential of human bone marrow stromal cells Expression of vascular cell adhesion molecule-1 indicates the differentiation potential of human bone marrow stromal cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 365, 3, 406-412 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 365, 3, 406-412 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 365, 3, 406-412 2008/01 英語 研究論文(学術雑誌) 公開

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タイトル言語:
外部資金:競争的資金 (科学研究費補助金)
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
挑戦的研究(萌芽) 代表 軟骨細胞系譜における分化段階特異的翻訳制御機構の解明 (平成30年度分) 2018/04/01〜2019/03/31
基盤研究(B) 代表 進行性骨化性線維異形成症の治療法開発に向けた病態解析 (平成30年度分) 2018/04/01〜2019/03/31
挑戦的研究(萌芽) 代表 軟骨細胞系譜における分化段階特異的翻訳制御機構の解明 (2019年度分) 2019/04/01〜2020/03/31
基盤研究(B) 代表 進行性骨化性線維異形成症の治療法開発に向けた病態解析 (2019年度分) 2019/04/01〜2020/03/31
基盤研究(B) 代表 進行性骨化性線維異形成症の治療法開発に向けた病態解析 (2020年度分) 2020/04/01〜2021/03/31
部局運営(役職等)
役職名 期間
化学物質管理委員会 2019/10/〜