松田 道行

最終更新日時: 2019/06/27 17:49:55

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氏名(漢字／フリガナ／アルファベット表記)
松田 道行／マツダ ミチユキ／Matsuda, Michiyuki
所属部署・職名(部局／所属／講座等／職名)
生命科学研究科／高次生命科学専攻システム生物学講座／教授
協力講座
部局 所属 講座等 職名
医学研究科 医学専攻 基礎病態学講座病態生物医学分野 教授
学部兼担
部局 所属 講座等 職名
医学部
学内兼務
部局 所属 講座等 職名
物質－細胞統合システム拠点 連携主任研究者
連絡先住所
種別 住所(日本語) 住所(英語)
職場 〒606-8501 京都市左京区吉田近衛町 Yoshida-Konoe-Cho, Sakyo-ku, Kyoto, Kyoto 606-8501
所属学会(国内)
学会名(日本語) 学会名(英語)
日本病理学会 The Japanese Society of Pathology
日本癌学会 Japanese Cancer Association
日本細胞生物学会 Japan Society for Cell Biology
所属学会(海外)
学会名(英語) 国名
American Society of Microbiology アメリカ
American Society of Biochemistry and Molecular Biology アメリカ
American Society of Cell Biology アメリカ
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
医学博士　 Doctor of Phylosopy 東京大学 The University of Tokyo
出身大学院・研究科等
大学名(日本語) 大学名(英語) 研究科名(日本語) 研究科名(英語) 専攻名(日本語) 専攻名(英語) 修了区分
東京大学 The University of Tokyo 大学院医学系研究科第三基礎医学専門課程博士課程 Graduate School of Medicine Division of the The Third Basic Medicine 修了
出身学校・専攻等
大学名(日本語) 大学名(英語) 学部名(日本語) 学部名(英語) 学科名(日本語) 学科名(英語) 卒業区分
東京大学 The University of Tokyo 医学部医学科 Faculty of Medicine School of Medicine 卒業
プロフィール
(日本語)
病理学の研究をしている。蛍光イメージング技術を使ったライブセルイメージングで生きた動物で病気をリアルタイムに理解を進め、また得られた画像データをもとにした数理モデルの構築を目指している。
(英語)
I am a pathologist. I use fluorescent microscopy to visuzalise the patholgoical state in vivo and build a mathematical model based on the imaging data.
個人ホームページ
URL
http://www.fret.lif.kyoto-u.ac.jp/
ORCID ID
https://orcid.org/0000-0002-5876-9969
researchmap URL
https://researchmap.jp/read0092255
研究テーマ
(日本語)
蛍光生体イメージングとシステム生物学の手法を使って「がんの包括的理解」を目指す
(英語)
Our goal is to create a virtual cell, in which we can simulate intracellular signal transduction cascades.
研究概要
(日本語)
フェルスター共鳴エネルギー移動（ＦＲＥＴ）の原理に基づくバイオセンサーを作成し、生細胞内での情報伝達を可視化している。ＦＲＥＴバイオセンサーは細胞内情報伝達系およびその活性をそれぞれの組織の個々の細胞で可視化するのに非常に優れたツールである。また、このようにして得られた画像データは細胞内情報伝達分子の生化学的性質をあらわすパラメータを抽出するためにも使用できる。実際、画像データから得られたパラメータを作って、細胞増殖因子情報伝達系のシミュレーションモデルも作成している。
(英語)
We are visualizing the growth signal trasduction cascades in living cells by using probes based on the principle of Foster resonance energy transfer (FRET). The FRET biosensors are extremely powerful to visualize the spatio-temporal regulation of signal transduction network within cells and to analyze the activities of individual cells within tissues. These FRET videos are also processed to extract parameters that characterize the property of each signaling molecule. We use these parameters obtained in living cells to build kinetic simulation models of growth signal transduction cascades.
研究分野（キーワード）
キーワード(日本語) キーワード(英語)
腫瘍学、病理学、細胞生物学、 Cancer Research, Pathology, Cell Biology
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Komatsubara Akira T, Goto Yuhei, Kondo Yohei, Matsuda Michiyuki, Aoki Kazuhiro Komatsubara Akira T, Goto Yuhei, Kondo Yohei, Matsuda Michiyuki, Aoki Kazuhiro Komatsubara Akira T, Goto Yuhei, Kondo Yohei, Matsuda Michiyuki, Aoki Kazuhiro Single-cell quantification of the concentrations and dissociation constants of endogenous proteins Single-cell quantification of the concentrations and dissociation constants of endogenous proteins Single-cell quantification of the concentrations and dissociation constants of endogenous proteins Journal of Biological Chemistry, jbc Journal of Biological Chemistry, jbc Journal of Biological Chemistry, jbc 2019 有 公開
Hino Naoya, Ichikawa Takafumi, Kimura Yasuhisa, Matsuda Michiyuki, Ueda Kazumitsu, Kioka Noriyuki Hino Naoya, Ichikawa Takafumi, Kimura Yasuhisa, Matsuda Michiyuki, Ueda Kazumitsu, Kioka Noriyuki Hino Naoya, Ichikawa Takafumi, Kimura Yasuhisa, Matsuda Michiyuki, Ueda Kazumitsu, Kioka Noriyuki An amphipathic helix of vinexin is necessary for a substrate stiffness-dependent conformational change in vinculin An amphipathic helix of vinexin is necessary for a substrate stiffness-dependent conformational change in vinculin An amphipathic helix of vinexin is necessary for a substrate stiffness-dependent conformational change in vinculin J Cell Sci, 132, 2, jcs217349 J Cell Sci, 132, 2, jcs217349 J Cell Sci, 132, 2, jcs217349 2019 有 公開
Yu Muta, Michiyuki Matsuda, Masamichi Imajo Yu Muta, Michiyuki Matsuda, Masamichi Imajo Yu Muta, Michiyuki Matsuda, Masamichi Imajo Dynamic ERK signaling regulation in intestinal tumorigenesis Dynamic ERK signaling regulation in intestinal tumorigenesis Dynamic ERK signaling regulation in intestinal tumorigenesis Molecular & Cellular Oncology, 5, 5, e1506684 Molecular & Cellular Oncology, 5, 5, e1506684 Molecular & Cellular Oncology, 5, 5, e1506684 2018/09 有 公開
Hikita T, Mirzapourshafiyi F, Barbacena P, Riddell M, Pasha A, Li M, Kawamura T, Brandes RP, Hirose T, Ohno S, Gerhardt H, Matsuda M, Franco CA, Nakayama M Hikita T, Mirzapourshafiyi F, Barbacena P, Riddell M, Pasha A, Li M, Kawamura T, Brandes RP, Hirose T, Ohno S, Gerhardt H, Matsuda M, Franco CA, Nakayama M Hikita T, Mirzapourshafiyi F, Barbacena P, Riddell M, Pasha A, Li M, Kawamura T, Brandes RP, Hirose T, Ohno S, Gerhardt H, Matsuda M, Franco CA, Nakayama M PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow. PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow. PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow. EMBO reports EMBO reports EMBO reports 2018/07 有 公開
Imanishi A, Murata T, Sato M, Hotta K, Imayoshi I, Matsuda M, Terai K Imanishi A, Murata T, Sato M, Hotta K, Imayoshi I, Matsuda M, Terai K Imanishi A, Murata T, Sato M, Hotta K, Imayoshi I, Matsuda M, Terai K A novel morphological marker for the analysis of molecular activities at the single-cell level. A novel morphological marker for the analysis of molecular activities at the single-cell level. A novel morphological marker for the analysis of molecular activities at the single-cell level. Cell structure and function Cell structure and function Cell structure and function 2018/06 有 公開
Komatsu N, Terai K, Imanishi A, Kamioka Y, Sumiyama K, Jin T, Okada Y, Nagai T, Matsuda M Komatsu N, Terai K, Imanishi A, Kamioka Y, Sumiyama K, Jin T, Okada Y, Nagai T, Matsuda M Komatsu N, Terai K, Imanishi A, Kamioka Y, Sumiyama K, Jin T, Okada Y, Nagai T, Matsuda M A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging. A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging. A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging. Scientific reports, 8, 1, 8984 Scientific reports, 8, 1, 8984 Scientific reports, 8, 1, 8984 2018/06 有 公開
Muta Y, Fujita Y, Sumiyama K, Sakurai A, Taketo MM, Chiba T, Seno H, Aoki K, Matsuda M, Imajo M Muta Y, Fujita Y, Sumiyama K, Sakurai A, Taketo MM, Chiba T, Seno H, Aoki K, Matsuda M, Imajo M Muta Y, Fujita Y, Sumiyama K, Sakurai A, Taketo MM, Chiba T, Seno H, Aoki K, Matsuda M, Imajo M Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine. Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine. Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine. Nature communications, 9, 1, 2174 Nature communications, 9, 1, 2174 Nature communications, 9, 1, 2174 2018/06 有 公開
Maryu G, Miura H, Uda Y, Komatsubara AT, Matsuda M, Aoki K Maryu G, Miura H, Uda Y, Komatsubara AT, Matsuda M, Aoki K Maryu G, Miura H, Uda Y, Komatsubara AT, Matsuda M, Aoki K Live-cell Imaging with Genetically Encoded Protein Kinase Activity Reporters. Live-cell Imaging with Genetically Encoded Protein Kinase Activity Reporters. Live-cell Imaging with Genetically Encoded Protein Kinase Activity Reporters. Cell structure and function, 43, 1, 61-74 Cell structure and function, 43, 1, 61-74 Cell structure and function, 43, 1, 61-74 2018/04 有 公開
Komatsu Naoki, Terai Kenta, Imanishi Ayako, Kamioka Yuji, Sumiyama Kenta, Jin Takashi, Okada Yasushi, Nagai Takeharu, Matsuda Michiyuki Komatsu Naoki, Terai Kenta, Imanishi Ayako, Kamioka Yuji, Sumiyama Kenta, Jin Takashi, Okada Yasushi, Nagai Takeharu, Matsuda Michiyuki Komatsu Naoki, Terai Kenta, Imanishi Ayako, Kamioka Yuji, Sumiyama Kenta, Jin Takashi, Okada Yasushi, Nagai Takeharu, Matsuda Michiyuki A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging Scientific reports, 8, 1, 8984 Scientific reports, 8, 1, 8984 Scientific reports, 8, 1, 8984 2018 有 公開
Maryu Gembu, Miura Haruko, Uda Yoichi, Komatsubara Akira T, Matsuda Michiyuki, Aoki Kazuhiro Maryu Gembu, Miura Haruko, Uda Yoichi, Komatsubara Akira T, Matsuda Michiyuki, Aoki Kazuhiro Maryu Gembu, Miura Haruko, Uda Yoichi, Komatsubara Akira T, Matsuda Michiyuki, Aoki Kazuhiro Live-cell imaging with genetically encoded protein kinase activity reporters Live-cell imaging with genetically encoded protein kinase activity reporters Live-cell imaging with genetically encoded protein kinase activity reporters Cell structure and function, 18003 Cell structure and function, 18003 Cell structure and function, 18003 2018 有 公開
Miura Haruko, Kondo Yohei, Matsuda Michiyuki, Aoki Kazuhiro Miura Haruko, Kondo Yohei, Matsuda Michiyuki, Aoki Kazuhiro Miura Haruko, Kondo Yohei, Matsuda Michiyuki, Aoki Kazuhiro Cell-to-cell heterogeneity in p38-mediated cross-inhibition of JNK causes stochastic cell death Cell-to-cell heterogeneity in p38-mediated cross-inhibition of JNK causes stochastic cell death Cell-to-cell heterogeneity in p38-mediated cross-inhibition of JNK causes stochastic cell death Cell reports, 24, 10, 2658 Cell reports, 24, 10, 2658 Cell reports, 24, 10, 2658 2018 有 公開
Muta Yu, Fujita Yoshihisa, Sumiyama Kenta, Sakurai Atsuro, Taketo M Mark, Chiba Tsutomu, Seno Hiroshi, Aoki Kazuhiro, Matsuda Michiyuki, Imajo Masamichi Muta Yu, Fujita Yoshihisa, Sumiyama Kenta, Sakurai Atsuro, Taketo M Mark, Chiba Tsutomu, Seno Hiroshi, Aoki Kazuhiro, Matsuda Michiyuki, Imajo Masamichi Muta Yu, Fujita Yoshihisa, Sumiyama Kenta, Sakurai Atsuro, Taketo M Mark, Chiba Tsutomu, Seno Hiroshi, Aoki Kazuhiro, Matsuda Michiyuki, Imajo Masamichi Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine Nature communications, 9, 1, 2174 Nature communications, 9, 1, 2174 Nature communications, 9, 1, 2174 2018 有 公開
Sano Takeshi, Kobayashi Takashi, Ogawa Osamu, Matsuda Michiyuki Sano Takeshi, Kobayashi Takashi, Ogawa Osamu, Matsuda Michiyuki Sano Takeshi, Kobayashi Takashi, Ogawa Osamu, Matsuda Michiyuki Gliding basal cell migration of the urothelium during wound healing Gliding basal cell migration of the urothelium during wound healing Gliding basal cell migration of the urothelium during wound healing The American journal of pathology, 188, 11, 2564 The American journal of pathology, 188, 11, 2564 The American journal of pathology, 188, 11, 2564 2018 有 公開
Ihermann-Hella Anneliis, Hirashima Tsuyoshi, Kupari Jussi, Kurtzeborn Kristen, Li Hao, Kwon Hyuk Nam, Cebrian Cristina, Soofi Abdul, Dapkunas Arvydas, Miinalainen Ilkka, others Ihermann-Hella Anneliis, Hirashima Tsuyoshi, Kupari Jussi, Kurtzeborn Kristen, Li Hao, Kwon Hyuk Nam, Cebrian Cristina, Soofi Abdul, Dapkunas Arvydas, Miinalainen Ilkka, others Ihermann-Hella Anneliis, Hirashima Tsuyoshi, Kupari Jussi, Kurtzeborn Kristen, Li Hao, Kwon Hyuk Nam, Cebrian Cristina, Soofi Abdul, Dapkunas Arvydas, Miinalainen Ilkka, others Dynamic MAPK/ERK activity sustains nephron progenitors through niche regulation and primes precursors for differentiation Dynamic MAPK/ERK activity sustains nephron progenitors through niche regulation and primes precursors for differentiation Dynamic MAPK/ERK activity sustains nephron progenitors through niche regulation and primes precursors for differentiation Stem cell reports, 11, 4, 912 Stem cell reports, 11, 4, 912 Stem cell reports, 11, 4, 912 2018 有 公開
Konishi Yoshinobu, Terai Kenta, Furuta Yasuhide, Kiyonari Hiroshi, Abe Takaya, Ueda Yoshihiro, Kinashi Tatsuo, Hamazaki Yoko, Takaori-Kondo Akifumi, Matsuda Michiyuki Konishi Yoshinobu, Terai Kenta, Furuta Yasuhide, Kiyonari Hiroshi, Abe Takaya, Ueda Yoshihiro, Kinashi Tatsuo, Hamazaki Yoko, Takaori-Kondo Akifumi, Matsuda Michiyuki Konishi Yoshinobu, Terai Kenta, Furuta Yasuhide, Kiyonari Hiroshi, Abe Takaya, Ueda Yoshihiro, Kinashi Tatsuo, Hamazaki Yoko, Takaori-Kondo Akifumi, Matsuda Michiyuki Live-cell FRET imaging reveals a role of extracellular signal-regulated kinase activity dynamics in thymocyte motility Live-cell FRET imaging reveals a role of extracellular signal-regulated kinase activity dynamics in thymocyte motility Live-cell FRET imaging reveals a role of extracellular signal-regulated kinase activity dynamics in thymocyte motility iScience, 10, 98 iScience, 10, 98 iScience, 10, 98 2018 有 公開
Konagaya Y, Terai K, Hirao Y, Takakura K, Imajo M, Kamioka Y, Sasaoka N, Kakizuka A, Sumiyama K, Asano T, Matsuda M. Konagaya Y, Terai K, Hirao Y, Takakura K, Imajo M, Kamioka Y, Sasaoka N, Kakizuka A, Sumiyama K, Asano T, Matsuda M. Konagaya Y, Terai K, Hirao Y, Takakura K, Imajo M, Kamioka Y, Sasaoka N, Kakizuka A, Sumiyama K, Asano T, Matsuda M. A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs Cell Reports, 21, 9, 2628-2638 Cell Reports, 21, 9, 2628-2638 Cell Reports, 21, 9, 2628-2638 2017/11 有 公開
Li C, Imanishi A, Komatsu N, Terai K, Amano M, Kaibuchi K, Matsuda M. Li C, Imanishi A, Komatsu N, Terai K, Amano M, Kaibuchi K, Matsuda M. Li C, Imanishi A, Komatsu N, Terai K, Amano M, Kaibuchi K, Matsuda M. A FRET biosensor for ROCK based on a consensus substrate sequence identified by KISS technology A FRET biosensor for ROCK based on a consensus substrate sequence identified by KISS technology A FRET biosensor for ROCK based on a consensus substrate sequence identified by KISS technology Cell Structure and Function, 42, 1, 1-13 Cell Structure and Function, 42, 1, 1-13 Cell Structure and Function, 42, 1, 1-13 2017 有 公開
Uda Y, Goto Y, Oda S, Kohchi T, Matsuda M, Aoki K. Uda Y, Goto Y, Oda S, Kohchi T, Matsuda M, Aoki K. Uda Y, Goto Y, Oda S, Kohchi T, Matsuda M, Aoki K. Efficient synthesis of phycocyanobilin in mammalian cells for optogenetic control of cell signaling Efficient synthesis of phycocyanobilin in mammalian cells for optogenetic control of cell signaling Efficient synthesis of phycocyanobilin in mammalian cells for optogenetic control of cell signaling Proceedings of the National Academy of Sciences of the United States of America, 114, 45, 11962-11967 Proceedings of the National Academy of Sciences of the United States of America, 114, 45, 11962-11967 Proceedings of the National Academy of Sciences of the United States of America, 114, 45, 11962-11967 2017 有 公開
Sakaue-Sawano A, Yo M, Komatsu N, Hiratsuka T, Kogure T, Hoshida T, Goshima N, Matsuda M, Miyoshi H, Miyawaki A. Sakaue-Sawano A, Yo M, Komatsu N, Hiratsuka T, Kogure T, Hoshida T, Goshima N, Matsuda M, Miyoshi H, Miyawaki A. Sakaue-Sawano A, Yo M, Komatsu N, Hiratsuka T, Kogure T, Hoshida T, Goshima N, Matsuda M, Miyoshi H, Miyawaki A. Genetically Encoded Tools for Optical Dissection of the Mammalian Cell Cycle Genetically Encoded Tools for Optical Dissection of the Mammalian Cell Cycle Genetically Encoded Tools for Optical Dissection of the Mammalian Cell Cycle Molecular Cell, 68, 3, 626-640.e5 Molecular Cell, 68, 3, 626-640.e5 Molecular Cell, 68, 3, 626-640.e5 2017 有 公開
Kamioka Y, Takakura K, Sumiyama K, Matsuda M. Kamioka Y, Takakura K, Sumiyama K, Matsuda M. Kamioka Y, Takakura K, Sumiyama K, Matsuda M. Intravital Förster resonance energy transfer imaging reveals osteopontin-mediated polymorphonuclear leukocyte activation by tumor cell emboli Intravital Förster resonance energy transfer imaging reveals osteopontin-mediated polymorphonuclear leukocyte activation by tumor cell emboli Intravital Förster resonance energy transfer imaging reveals osteopontin-mediated polymorphonuclear leukocyte activation by tumor cell emboli Cancer Science, 108, 2, 226-235 Cancer Science, 108, 2, 226-235 Cancer Science, 108, 2, 226-235 2017 有 公開
Hiratsuka T, Sano T, Kato H, Komatsu N, Imajo M, Kamioka Y, Sumiyama K, Banno F, Miyata T, Matsuda M. Hiratsuka T, Sano T, Kato H, Komatsu N, Imajo M, Kamioka Y, Sumiyama K, Banno F, Miyata T, Matsuda M. Hiratsuka T, Sano T, Kato H, Komatsu N, Imajo M, Kamioka Y, Sumiyama K, Banno F, Miyata T, Matsuda M. Live imaging of extracellular signal-regulated kinase and protein kinase A activities during thrombus formation in mice expressing biosensors based on Förster resonance energy transfer Live imaging of extracellular signal-regulated kinase and protein kinase A activities during thrombus formation in mice expressing biosensors based on Förster resonance energy transfer Live imaging of extracellular signal-regulated kinase and protein kinase A activities during thrombus formation in mice expressing biosensors based on Förster resonance energy transfer Journal of Thrombosis and Haemostasis, 15, 7, 1487-1499 Journal of Thrombosis and Haemostasis, 15, 7, 1487-1499 Journal of Thrombosis and Haemostasis, 15, 7, 1487-1499 2017 有 公開
Aoki K, Kondo Y, Naoki H, Hiratsuka T, Itoh R.E, Matsuda M. Aoki K, Kondo Y, Naoki H, Hiratsuka T, Itoh R.E, Matsuda M. Aoki K, Kondo Y, Naoki H, Hiratsuka T, Itoh R.E, Matsuda M. Propagating Wave of ERK Activation Orients Collective Cell Migration Propagating Wave of ERK Activation Orients Collective Cell Migration Propagating Wave of ERK Activation Orients Collective Cell Migration Developmental Cell, 43, 3, 305-317.e5 Developmental Cell, 43, 3, 305-317.e5 Developmental Cell, 43, 3, 305-317.e5 2017 有 公開
Candeias M.M, Hagiwara M, Matsuda M. Candeias M.M, Hagiwara M, Matsuda M. Candeias M.M, Hagiwara M, Matsuda M. Cancer-specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis Cancer-specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis Cancer-specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis EMBO Reports, 17, 11, 1542-1551 EMBO Reports, 17, 11, 1542-1551 EMBO Reports, 17, 11, 1542-1551 2016 有 公開
Kawabata N, Matsuda M. Kawabata N, Matsuda M. Kawabata N, Matsuda M. Cell density-dependent increase in tyrosine-monophosphorylated ERK2 in MDCK Cells expressing active ras or raf Cell density-dependent increase in tyrosine-monophosphorylated ERK2 in MDCK Cells expressing active ras or raf Cell density-dependent increase in tyrosine-monophosphorylated ERK2 in MDCK Cells expressing active ras or raf PLoS ONE, 11, 12 PLoS ONE, 11, 12 PLoS ONE, 11, 12 2016 有 公開
Okuchi Y, Imajo M, Mizuno R, Kamioka Y, Miyoshi H, Taketo M.M, Nagayama S, Sakai Y, Matsuda M. Okuchi Y, Imajo M, Mizuno R, Kamioka Y, Miyoshi H, Taketo M.M, Nagayama S, Sakai Y, Matsuda M. Okuchi Y, Imajo M, Mizuno R, Kamioka Y, Miyoshi H, Taketo M.M, Nagayama S, Sakai Y, Matsuda M. Identification of aging-associated gene expression signatures that precede intestinal tumorigenesis Identification of aging-associated gene expression signatures that precede intestinal tumorigenesis Identification of aging-associated gene expression signatures that precede intestinal tumorigenesis PLoS ONE, 11, 9 PLoS ONE, 11, 9 PLoS ONE, 11, 9 2016 有 公開
Yamauchi F, Kamioka Y, Yano T, Matsuda M. Yamauchi F, Kamioka Y, Yano T, Matsuda M. Yamauchi F, Kamioka Y, Yano T, Matsuda M. In vivo FRET imaging of tumor endothelial cells highlights a role of low PKA activity in vascular hyperpermeability In vivo FRET imaging of tumor endothelial cells highlights a role of low PKA activity in vascular hyperpermeability In vivo FRET imaging of tumor endothelial cells highlights a role of low PKA activity in vascular hyperpermeability Cancer Research, 76, 18, 5266-5276 Cancer Research, 76, 18, 5266-5276 Cancer Research, 76, 18, 5266-5276 2016 有 公開
Sano T, Kobayashi T, Negoro H, Sengiku A, Hiratsuka T, Kamioka Y, Liou L.S, Ogawa O, Matsuda M. Sano T, Kobayashi T, Negoro H, Sengiku A, Hiratsuka T, Kamioka Y, Liou L.S, Ogawa O, Matsuda M. Sano T, Kobayashi T, Negoro H, Sengiku A, Hiratsuka T, Kamioka Y, Liou L.S, Ogawa O, Matsuda M. Intravital imaging of mouse urothelium reveals activation of extracellular signal-regulated kinase by stretch-induced intravesical release of ATP Intravital imaging of mouse urothelium reveals activation of extracellular signal-regulated kinase by stretch-induced intravesical release of ATP Intravital imaging of mouse urothelium reveals activation of extracellular signal-regulated kinase by stretch-induced intravesical release of ATP Physiological Reports, 4, 21 Physiological Reports, 4, 21 Physiological Reports, 4, 21 2016 有 公開
Takaoka S, Kamioka Y, Takakura K, Baba A, Shime H, Seya T, Matsuda M. Takaoka S, Kamioka Y, Takakura K, Baba A, Shime H, Seya T, Matsuda M. Takaoka S, Kamioka Y, Takakura K, Baba A, Shime H, Seya T, Matsuda M. Live imaging of transforming growth factor-β activated kinase 1 activation in Lewis lung carcinoma 3LL cells implanted into syngeneic mice and treated with polyinosinic: Polycytidylic acid Live imaging of transforming growth factor-β activated kinase 1 activation in Lewis lung carcinoma 3LL cells implanted into syngeneic mice and treated with polyinosinic: Polycytidylic acid Live imaging of transforming growth factor-β activated kinase 1 activation in Lewis lung carcinoma 3LL cells implanted into syngeneic mice and treated with polyinosinic: Polycytidylic acid Cancer Science, 107, 5, 644-652 Cancer Science, 107, 5, 644-652 Cancer Science, 107, 5, 644-652 2016 有 公開
Maryu G, Matsuda M, Aoki K. Maryu G, Matsuda M, Aoki K. Maryu G, Matsuda M, Aoki K. Multiplexed fluorescence imaging of ERK and akt activities and cell-cycle progression Multiplexed fluorescence imaging of ERK and akt activities and cell-cycle progression Multiplexed fluorescence imaging of ERK and akt activities and cell-cycle progression Cell Structure and Function, 41, 2, 81-92 Cell Structure and Function, 41, 2, 81-92 Cell Structure and Function, 41, 2, 81-92 2016 有 公開
Sakamoto K, Fukushima Y, Ito K, Matsuda M, Nagata S, Minato N, Hattori M. Sakamoto K, Fukushima Y, Ito K, Matsuda M, Nagata S, Minato N, Hattori M. Sakamoto K, Fukushima Y, Ito K, Matsuda M, Nagata S, Minato N, Hattori M. Osteopontin in spontaneous germinal centers inhibits apoptotic cell engulfment and promotes anti-nuclear antibody production in lupus-prone mice Osteopontin in spontaneous germinal centers inhibits apoptotic cell engulfment and promotes anti-nuclear antibody production in lupus-prone mice Osteopontin in spontaneous germinal centers inhibits apoptotic cell engulfment and promotes anti-nuclear antibody production in lupus-prone mice Journal of Immunology, 197, 6, 2177-2186 Journal of Immunology, 197, 6, 2177-2186 Journal of Immunology, 197, 6, 2177-2186 2016 有 公開
Yamao M, Aoki K, Yukinawa N, Ishii S, Matsuda M, Naoki H. Yamao M, Aoki K, Yukinawa N, Ishii S, Matsuda M, Naoki H. Yamao M, Aoki K, Yukinawa N, Ishii S, Matsuda M, Naoki H. Two new FRET imaging measures: Linearly proportional to and highly contrasting the fraction of active molecules Two new FRET imaging measures: Linearly proportional to and highly contrasting the fraction of active molecules Two new FRET imaging measures: Linearly proportional to and highly contrasting the fraction of active molecules PLoS ONE, 11, 10 PLoS ONE, 11, 10 PLoS ONE, 11, 10 2016 有 公開
Mizuno R, Kamioka Y, Sakai Y, Matsuda M. Mizuno R, Kamioka Y, Sakai Y, Matsuda M. Mizuno R, Kamioka Y, Sakai Y, Matsuda M. Visualization of signaling molecules during neutrophil recruitment in transgenic mice expressing FRET Biosensors Visualization of signaling molecules during neutrophil recruitment in transgenic mice expressing FRET Biosensors Visualization of signaling molecules during neutrophil recruitment in transgenic mice expressing FRET Biosensors Methods in Molecular Biology, 1422, 149-160 Methods in Molecular Biology, 1422, 149-160 Methods in Molecular Biology, 1422, 149-160 2016 有 公開
Kamioka Y, Mizuno R, Matsuda M. Kamioka Y, Mizuno R, Matsuda M. Kamioka Y, Mizuno R, Matsuda M In vivo imaging of intracellular signaling molecules: Come/Stop signals of neutrophils during acute inflammation In vivo imaging of intracellular signaling molecules: Come/Stop signals of neutrophils during acute inflammation In vivo imaging of intracellular signaling molecules: Come/Stop signals of neutrophils during acute inflammation. [Rinshō ketsueki] The Japanese journal of clinical hematology, 56, 6, 586-593 [Rinshō ketsueki] The Japanese journal of clinical hematology, 56, 6, 586-593 [Rinsho ketsueki] The Japanese journal of clinical hematology, 56, 6, 586-593 2015 有 公開
Hirata E, Girotti M.R, Viros A, Hooper S, Spencer-Dene B, Matsuda M, Larkin J, Marais R, Sahai E. Hirata E, Girotti M.R, Viros A, Hooper S, Spencer-Dene B, Matsuda M, Larkin J, Marais R, Sahai E. Hirata E, Girotti M.R, Viros A, Hooper S, Spencer-Dene B, Matsuda M, Larkin J, Marais R, Sahai E. Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK Signaling Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK Signaling Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK Signaling Cancer Cell, 27, 4, 574-588 Cancer Cell, 27, 4, 574-588 Cancer Cell, 27, 4, 574-588 2015 有 公開
Komatsubara A.T, Matsuda M, Aoki K. Komatsubara A.T, Matsuda M, Aoki K. Komatsubara A.T, Matsuda M, Aoki K. Quantitative analysis of recombination between YFP and CFP genes of FRET biosensors introduced by lentiviral or retroviral gene transfer Quantitative analysis of recombination between YFP and CFP genes of FRET biosensors introduced by lentiviral or retroviral gene transfer Quantitative analysis of recombination between YFP and CFP genes of FRET biosensors introduced by lentiviral or retroviral gene transfer Scientific Reports, 5 Scientific Reports, 5 Scientific Reports, 5 2015 有 公開
Yamaguchi T, Goto A, Nakahara I, Yawata S, Hikida T, Matsuda M, Funabiki K, Nakanishi S. Yamaguchi T, Goto A, Nakahara I, Yawata S, Hikida T, Matsuda M, Funabiki K, Nakanishi S. Yamaguchi T, Goto A, Nakahara I, Yawata S, Hikida T, Matsuda M, Funabiki K, Nakanishi S. Role of PKA signaling in D2 receptor-expressing neurons in the core of the nucleus accumbens in aversive learning Role of PKA signaling in D2 receptor-expressing neurons in the core of the nucleus accumbens in aversive learning Role of PKA signaling in D2 receptor-expressing neurons in the core of the nucleus accumbens in aversive learning Proceedings of the National Academy of Sciences of the United States of America, 112, 36, 11383-11388 Proceedings of the National Academy of Sciences of the United States of America, 112, 36, 11383-11388 Proceedings of the National Academy of Sciences of the United States of America, 112, 36, 11383-11388 2015 有 公開
Komatsu N, Fujita Y, Matsuda M, Aoki K. Komatsu N, Fujita Y, Matsuda M, Aoki K. Komatsu N, Fujita Y, Matsuda M, Aoki K. mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells Oncogene, 34, 45, 5607-5616 Oncogene, 34, 45, 5607-5616 Oncogene, 34, 45, 5607-5616 2015 有 公開
Goto A, Nakahara I, Yamaguchi T, Kamioka Y, Sumiyama K, Matsuda M, Nakanishi S, Funabiki K. Goto A, Nakahara I, Yamaguchi T, Kamioka Y, Sumiyama K, Matsuda M, Nakanishi S, Funabiki K. Goto A, Nakahara I, Yamaguchi T, Kamioka Y, Sumiyama K, Matsuda M, Nakanishi S, Funabiki K Circuit-dependent striatal PKA and ERK signaling underlies rapid behavioral shift in mating reaction of male mice Circuit-dependent striatal PKA and ERK signaling underlies rapid behavioral shift in mating reaction of male mice Circuit-dependent striatal PKA and ERK signaling underlies rapid behavioral shift in mating reaction of male mice. Proceedings of the National Academy of Sciences of the United States of America, 112, 21, 6718-6723 Proceedings of the National Academy of Sciences of the United States of America, 112, 21, 6718-6723 Proceedings of the National Academy of Sciences of the United States of America, 112, 21, 6718-6723 2015 有 公開
Hiratsuka T, Fujita Y, Naoki H, Aoki K, Kamioka Y, Matsuda M. Hiratsuka T, Fujita Y, Naoki H, Aoki K, Kamioka Y, Matsuda M. Hiratsuka T, Fujita Y, Naoki H, Aoki K, Kamioka Y, Matsuda M Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin. eLife, 2015, 4, e05178 eLife, 2015, 4, e05178 eLife, 2015, 4, e05178 2015 有 公開
Wakayama Y, Fukuhara S, Ando K, Matsuda M, Mochizuki N. Wakayama Y, Fukuhara S, Ando K, Matsuda M, Mochizuki N. Wakayama Y, Fukuhara S, Ando K, Matsuda M, Mochizuki N Cdc42 mediates Bmp - Induced sprouting angiogenesis through Fmnl3-driven assembly of endothelial filopodia in zebrafish Cdc42 mediates Bmp - Induced sprouting angiogenesis through Fmnl3-driven assembly of endothelial filopodia in zebrafish Cdc42 mediates Bmp-induced sprouting angiogenesis through Fmnl3-driven assembly of endothelial filopodia in zebrafish. Developmental Cell, 32, 1, 109-122 Developmental Cell, 32, 1, 109-122 Developmental cell, 32, 1, 109-122 2015 有 公開
Yamao M, Naoki H, Kunida K, Aoki K, Matsuda M, Ishii S. Yamao M, Naoki H, Kunida K, Aoki K, Matsuda M, Ishii S. Yamao M, Naoki H, Kunida K, Aoki K, Matsuda M, Ishii S. Distinct predictive performance of Rac1 and Cdc42 in cell migration Distinct predictive performance of Rac1 and Cdc42 in cell migration Distinct predictive performance of Rac1 and Cdc42 in cell migration Scientific Reports, 5 Scientific Reports, 5 Scientific Reports, 5 2015 有 公開
Kumagai Y, Naoki H, Nakasyo E, Kamioka Y, Kiyokawa E, Matsuda M. Kumagai Y, Naoki H, Nakasyo E, Kamioka Y, Kiyokawa E, Matsuda M. Kumagai Y, Naoki H, Nakasyo E, Kamioka Y, Kiyokawa E, Matsuda M. Heterogeneity in ERK activity as visualized by in vivo FRET imaging of mammary tumor cells developed in MMTV-Neu mice Heterogeneity in ERK activity as visualized by in vivo FRET imaging of mammary tumor cells developed in MMTV-Neu mice Heterogeneity in ERK activity as visualized by in vivo FRET imaging of mammary tumor cells developed in MMTV-Neu mice Oncogene, 34, 8, 1051-1057 Oncogene, 34, 8, 1051-1057 Oncogene, 34, 8, 1051-1057 2015 有 公開
Fujita Y, Komatsu N, Matsuda M, Aoki K. Fujita Y, Komatsu N, Matsuda M, Aoki K. Fujita Y, Komatsu N, Matsuda M, Aoki K Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs. FEBS Journal, 281, 14, 3177-3192 FEBS Journal, 281, 14, 3177-3192 The FEBS journal, 281, 14, 3177-3192 2014 有 公開
Yukinaga H, Shionyu C, Hirata E, Ui-Tei K, Nagashima T, Kondo S, Okada-Hatakeyama M, Naoki H, Matsuda M. Yukinaga H, Shionyu C, Hirata E, Ui-Tei K, Nagashima T, Kondo S, Okada-Hatakeyama M, Naoki H, Matsuda M. Yukinaga H, Shionyu C, Hirata E, Ui-Tei K, Nagashima T, Kondo S, Okada-Hatakeyama M, Naoki H, Matsuda M Fluctuation of Rac1 activity is associated with the phenotypic and transcriptional heterogeneity of glioma cells Fluctuation of Rac1 activity is associated with the phenotypic and transcriptional heterogeneity of glioma cells Fluctuation of Rac1 activity is associated with the phenotypic and transcriptional heterogeneity of glioma cells. Journal of Cell Science, 127, 8, 1805-1815 Journal of Cell Science, 127, 8, 1805-1815 Journal of cell science, 127, 8, 1805-1815 2014 有 公開
Y. Kumagai; Y. Kamioka; S. Yagi; M. Matsuda; E. Kiyokawa Y. Kumagai; Y. Kamioka; S. Yagi; M. Matsuda; E. Kiyokawa Kumagai Y, Kamioka Y, Yagi S, Matsuda M, Kiyokawa E A genetically encoded Förster resonance energy transfer biosensor for two-photon excitation microscopy A genetically encoded Förster resonance energy transfer biosensor for two-photon excitation microscopy A genetically encoded Förster resonance energy transfer biosensor for two-photon excitation microscopy. Analytical Biochemistry, 413, 2, 192-199 Analytical Biochemistry, 413, 2, 192-199 Analytical biochemistry, 413, 2, 192-199 2011/06 有 日本語 公開
E. Kiyokawa; K. Aoki; T. Nakamura; M. Matsuda E. Kiyokawa; K. Aoki; T. Nakamura; M. Matsuda Kiyokawa E, Aoki K, Nakamura T, Matsuda M Spatiotemporal regulation of small GTPases as revealed by probes based on the principle of f̈orster resonance energy transfer (FRET): Implications for signaling and pharmacology Spatiotemporal regulation of small GTPases as revealed by probes based on the principle of f̈orster resonance energy transfer (FRET): Implications for signaling and pharmacology Spatiotemporal regulation of small GTPases as revealed by probes based on the principle of Förster Resonance Energy Transfer (FRET): Implications for signaling and pharmacology. Annual Review of Pharmacology and Toxicology, 51, 337-358 Annual Review of Pharmacology and Toxicology, 51, 337-358 Annual review of pharmacology and toxicology, 51, 337-358 2011 有 日本語 公開
T. Nishioka; M.A. Frohman; M. Matsuda; E. Kiyokawa T. Nishioka; M.A. Frohman; M. Matsuda; E. Kiyokawa Nishioka T, Frohman MA, Matsuda M, Kiyokawa E Heterogeneity of phosphatidic acid levels and distribution at the plasma membrane in living cells as visualized by a Förster Resonance Energy Transfer (FRET) biosensor Heterogeneity of phosphatidic acid levels and distribution at the plasma membrane in living cells as visualized by a Förster Resonance Energy Transfer (FRET) biosensor Heterogeneity of phosphatidic acid levels and distribution at the plasma membrane in living cells as visualized by a Föster resonance energy transfer (FRET) biosensor. Journal of Biological Chemistry, 285, 46, 35979-35987 Journal of Biological Chemistry, 285, 46, 35979-35987 The Journal of biological chemistry, 285, 46, 35979-35987 2010/11 有 日本語 公開
Nakamura, Takeshi;Matsuda, Michiyuki Nakamura, Takeshi;Matsuda, Michiyuki Nakamura T, Matsuda M In vivo imaging of signal transduction cascades with probes based on Förster Resonance Energy Transfer (FRET). In vivo imaging of signal transduction cascades with probes based on Förster Resonance Energy Transfer (FRET). In vivo imaging of signal transduction cascades with probes based on Förster Resonance Energy Transfer (FRET). Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.], Chapter 14, Unit 14.10 Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.], Chapter 14, Unit 14.10 Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.], Chapter 14, Unit 14.10 2009/12 有 日本語 公開
Y. Ohba; M. Matsuda Y. Ohba; M. Matsuda Visualization of signal transduction of Ras Visualization of signal transduction of Ras Seikagaku. The Journal of Japanese Biochemical Society, 76, 1, 16-28 Seikagaku. The Journal of Japanese Biochemical Society, 76, 1, 16-28 , 76, 1, 16-28 2004 有 日本語 公開
Sadaie W, Harada Y, Matsuda M, Aoki K Sadaie W, Harada Y, Matsuda M, Aoki K Quantitative in vivo fluorescence cross-correlation analyses highlight the importance of competitive effects in the regulation of protein-protein interactions. Quantitative in vivo fluorescence cross-correlation analyses highlight the importance of competitive effects in the regulation of protein-protein interactions. Molecular and cellular biology, 34, 17, 3272-3290 , 34, 17, 3272-3290 Molecular and cellular biology, 34, 17, 3272-3290 2014/09 有 公開
Mizuno R, Kamioka Y, Kabashima K, Imajo M, Sumiyama K, Nakasho E, Ito T, Hamazaki Y, Okuchi Y, Sakai Y, Kiyokawa E, Matsuda M Mizuno R, Kamioka Y, Kabashima K, Imajo M, Sumiyama K, Nakasho E, Ito T, Hamazaki Y, Okuchi Y, Sakai Y, Kiyokawa E, Matsuda M In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines. In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines. The Journal of experimental medicine, 211, 6, 1123-1136 , 211, 6, 1123-1136 The Journal of experimental medicine, 211, 6, 1123-1136 2014/06 有 公開
Ueyama T, Sakaguchi H, Nakamura T, Goto A, Morioka S, Shimizu A, Nakao K, Hishikawa Y, Ninoyu Y, Kassai H, Suetsugu S, Koji T, Fritzsch B, Yonemura S, Hisa Y, Matsuda M, Aiba A, Saito N Ueyama T, Sakaguchi H, Nakamura T, Goto A, Morioka S, Shimizu A, Nakao K, Hishikawa Y, Ninoyu Y, Kassai H, Suetsugu S, Koji T, Fritzsch B, Yonemura S, Hisa Y, Matsuda M, Aiba A, Saito N Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells. Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells. Journal of cell science, 127, Pt 9, 2040-2052 , 127, Pt 9, 2040-2052 Journal of cell science, 127, Pt 9, 2040-2052 2014/05 有 公開
Goto A, Kamioka Y, Matsuda M Goto A, Kamioka Y, Matsuda M PKA modulation of Rac in neuronal cells. PKA modulation of Rac in neuronal cells. Frontiers in cellular neuroscience, 8, 321 , 8, 321 Frontiers in cellular neuroscience, 8, 321 2014 有 公開
Miura H, Matsuda M, Aoki K Miura H, Matsuda M, Aoki K Development of a FRET biosensor with high specificity for Akt. Development of a FRET biosensor with high specificity for Akt. Cell structure and function, 39, 1, 9-20 , 39, 1, 9-20 Cell structure and function, 39, 1, 9-20 2014 有 公開
K. Aoki; Y. Kumagai; A. Sakurai; N. Komatsu; Y. Fujita; C. Shionyu; M. Matsuda K. Aoki; Y. Kumagai; A. Sakurai; N. Komatsu; Y. Fujita; C. Shionyu; M. Matsuda Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation Molecular Cell, 52, 4, 529-540 , 52, 4, 529-540 Molecular Cell, 52, 4, 529-540 2013/11 有 英語 公開
K. Aoki; Y. Kamioka; M. Matsuda K. Aoki; Y. Kamioka; M. Matsuda Fluorescence resonance energy transfer imaging of cell signaling from in vitro to in vivo: Basis of biosensor construction, live imaging, and image processing Fluorescence resonance energy transfer imaging of cell signaling from in vitro to in vivo: Basis of biosensor construction, live imaging, and image processing Development Growth and Differentiation, 55, 4, 515-522 , 55, 4, 515-522 Development Growth and Differentiation, 55, 4, 515-522 2013/05 有 英語 公開
A. Goto; K. Sumiyama; Y. Kamioka; E. Nakasyo; K. Ito; M. Iwasaki; H. Enomoto; M. Matsuda A. Goto; K. Sumiyama; Y. Kamioka; E. Nakasyo; K. Ito; M. Iwasaki; H. Enomoto; M. Matsuda GDNF and endothelin 3 regulate migration of enteric neural crest-derived cells via protein kinase A and Rac1 GDNF and endothelin 3 regulate migration of enteric neural crest-derived cells via protein kinase A and Rac1 Journal of Neuroscience, 33, 11, 4901-4912 , 33, 11, 4901-4912 Journal of Neuroscience, 33, 11, 4901-4912 2013/03/13 有 英語 公開
Y. Mori; S. Yagi; A. Sakurai; M. Matsuda; E. Kiyokawa Y. Mori; S. Yagi; A. Sakurai; M. Matsuda; E. Kiyokawa Insufficient ability of Rac1b to perturb cystogenesis. Insufficient ability of Rac1b to perturb cystogenesis. Small GTPases, 4, 1, 9-15 , 4, 1, 9-15 Small GTPases, 4, 1, 9-15 2013/01 有 英語 公開
K. Aoki; K. Takahashi; K. Kaizu; M. Matsuda K. Aoki; K. Takahashi; K. Kaizu; M. Matsuda A quantitative model of ERK MAP kinase phosphorylation in crowded media A quantitative model of ERK MAP kinase phosphorylation in crowded media Scientific Reports, 3, 1541 , 3, 1541 Scientific Reports, 3, 1541 2013 有 英語 公開
H. Miura; M. Matsuda; K. Aoki H. Miura; M. Matsuda; K. Aoki Development of a FRET biosensor with high specificity for Akt Development of a FRET biosensor with high specificity for Akt Cell Structure and Function, 39, 1, 9-10 , 39, 1, 9-10 Cell Structure and Function, 39, 1, 9-10 2013 有 英語 公開
Y. Kagawa; S. Matsumoto; Y. Kamioka; K. Mimori; Y. Naito; T. Ishii; D. Okuzaki; N. Nishida; S. Maeda; A. Naito; J. Kikuta; K. Nishikawa; J. Nishimura; N. Haraguchi; I. Takemasa; T. Mizushima; M. Ikeda; H. Yamamoto; M. Sekimoto; H. Ishii; Y. Doki; M. Matsuda; A. Kikuchi; M. Mori; M. Ishii Y. Kagawa; S. Matsumoto; Y. Kamioka; K. Mimori; Y. Naito; T. Ishii; D. Okuzaki; N. Nishida; S. Maeda; A. Naito; J. Kikuta; K. Nishikawa; J. Nishimura; N. Haraguchi; I. Takemasa; T. Mizushima; M. Ikeda; H. Yamamoto; M. Sekimoto; H. Ishii; Y. Doki; M. Matsuda; A. Kikuchi; M. Mori; M. Ishii Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo PLoS ONE, 8, 12 , 8, 12 PLoS ONE, 8, 12 2013 有 英語 公開
Sakurai A, Matsuda M, Kiyokawa E Sakurai A, Matsuda M, Kiyokawa E Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis. Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis. The Journal of biological chemistry, 287, 38, 31703-31711 , 287, 38, 31703-31711 The Journal of biological chemistry, 287, 38, 31703-31711 2012/09 有 公開
K. Kunida; M. Matsuda; K. Aoki K. Kunida; M. Matsuda; K. Aoki FRET imaging and statistical signal processing reveal positive and negative feedback loops regulating the morphology of randomly migrating HT-1080 cells FRET imaging and statistical signal processing reveal positive and negative feedback loops regulating the morphology of randomly migrating HT-1080 cells Journal of Cell Science, 125, 10, 2381-2392 , 125, 10, 2381-2392 Journal of Cell Science, 125, 10, 2381-2392 2012/05/15 有 英語 公開
K. Aoki; N. Komatsu; E. Hirata; Y. Kamioka; M. Matsuda K. Aoki; N. Komatsu; E. Hirata; Y. Kamioka; M. Matsuda Stable expression of FRET biosensors: A new light in cancer research Stable expression of FRET biosensors: A new light in cancer research Cancer Science, 103, 4, 614-619 , 103, 4, 614-619 Cancer Science, 103, 4, 614-619 2012/04 有 英語 公開
S. Yagi; M. Matsuda; E. Kiyokawa S. Yagi; M. Matsuda; E. Kiyokawa Suppression of Rac1 activity at the apical membrane of MDCK cells is essential for cyst structure maintenance Suppression of Rac1 activity at the apical membrane of MDCK cells is essential for cyst structure maintenance EMBO Reports, 13, 3, 237-243 , 13, 3, 237-243 EMBO Reports, 13, 3, 237-243 2012/03 有 英語 公開
E. Hirata; H. Yukinaga; Y. Kamioka; Y. Arakawa; S. Miyamoto; T. Okada; E. Sahai; M. Matsuda E. Hirata; H. Yukinaga; Y. Kamioka; Y. Arakawa; S. Miyamoto; T. Okada; E. Sahai; M. Matsuda In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family gtpases in glioblastoma cell invasion In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family gtpases in glioblastoma cell invasion Journal of Cell Science, 125, 4, 858-868 , 125, 4, 858-868 Journal of Cell Science, 125, 4, 858-868 2012/02/15 有 英語 公開
A. Elfenbein; A. Lanahan; T.X. Zhou; A. Yamasaki; E. Tkachenko; M. Matsuda; M. Simons A. Elfenbein; A. Lanahan; T.X. Zhou; A. Yamasaki; E. Tkachenko; M. Matsuda; M. Simons Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis Science Signaling, 5, 223 , 5, 223 Science Signaling, 5, 223 2012 有 英語 公開
S. Yagi; M. Matsuda; E. Kiyokawa S. Yagi; M. Matsuda; E. Kiyokawa Chimaerin Suppresses Rac1 Activation at the Apical Membrane to Maintain the Cyst Structure Chimaerin Suppresses Rac1 Activation at the Apical Membrane to Maintain the Cyst Structure PLoS ONE, 7, 12, e52258 , 7, 12, e52258 PLoS ONE, 7, 12, e52258 2012 有 英語 公開
Y. Kamioka; K. Sumiyama; R. Mizuno; Y. Sakai; E. Hirata; E. Kiyokawa; M. Matsuda Y. Kamioka; K. Sumiyama; R. Mizuno; Y. Sakai; E. Hirata; E. Kiyokawa; M. Matsuda Live imaging of protein kinase activities in transgenic mice expressing FRET biosensors Live imaging of protein kinase activities in transgenic mice expressing FRET biosensors Cell Structure and Function, 37, 1, 65-73 , 37, 1, 65-73 Cell Structure and Function, 37, 1, 65-73 2012 有 英語 公開
N. Komatsu; K. Aoki; M. Yamada; H. Yukinaga; Y. Fujita; Y. Kamioka; M. Matsuda N. Komatsu; K. Aoki; M. Yamada; H. Yukinaga; Y. Fujita; Y. Kamioka; M. Matsuda Development of an optimized backbone of FRET biosensors for kinases and GTPases Development of an optimized backbone of FRET biosensors for kinases and GTPases Molecular Biology of the Cell, 22, 23, 4647-4656 , 22, 23, 4647-4656 Molecular Biology of the Cell, 22, 23, 4647-4656 2011/12/01 有 英語 公開
M. Parrini; A. Sadou-Dubourgnoux; K. Aoki; K. Kunida; M. Biondini; A. Hatzoglou; P. Poullet; E. Formstecher; C. Yeaman; M. Matsuda; C. Rossé; J. Camonis M. Parrini; A. Sadou-Dubourgnoux; K. Aoki; K. Kunida; M. Biondini; A. Hatzoglou; P. Poullet; E. Formstecher; C. Yeaman; M. Matsuda; C. Rossé; J. Camonis SH3BP1, an Exocyst-Associated RhoGAP, Inactivates Rac1 at the Front to Drive Cell Motility SH3BP1, an Exocyst-Associated RhoGAP, Inactivates Rac1 at the Front to Drive Cell Motility Molecular Cell, 42, 5, 650-661 , 42, 5, 650-661 Molecular Cell, 42, 5, 650-661 2011/06/10 有 英語 公開
A. Goto; M. Hoshino; M. Matsuda; T. Nakamura A. Goto; M. Hoshino; M. Matsuda; T. Nakamura Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells Molecular Biology of the Cell, 22, 10, 1780-1790 , 22, 10, 1780-1790 Molecular Biology of the Cell, 22, 10, 1780-1790 2011/05/15 有 英語 公開
M. Mitsushima; K. Aoki; M. Ebisuya; S. Matsumura; T. Yamamoto; M. Matsuda; F. Toyoshima; E. Nishida M. Mitsushima; K. Aoki; M. Ebisuya; S. Matsumura; T. Yamamoto; M. Matsuda; F. Toyoshima; E. Nishida Revolving movement of a dynamic cluster of actin filaments during mitosis Revolving movement of a dynamic cluster of actin filaments during mitosis Journal of Cell Biology, 191, 3, 453-462 , 191, 3, 453-462 Journal of Cell Biology, 191, 3, 453-462 2010/11/01 有 英語 公開
A. Tunceroglu; M. Matsuda; R.B. Birge A. Tunceroglu; M. Matsuda; R.B. Birge Real-time fluorescent resonance energy transfer analysis to monitor drug resistance in chronic myelogenous leukemia Real-time fluorescent resonance energy transfer analysis to monitor drug resistance in chronic myelogenous leukemia Molecular Cancer Therapeutics, 9, 11, 3065-3073 , 9, 11, 3065-3073 Molecular Cancer Therapeutics, 9, 11, 3065-3073 2010/11 有 英語 公開
Y. Kamioka; S. Yasuda; Y. Fujita; K. Aoki; M. Matsuda Y. Kamioka; S. Yasuda; Y. Fujita; K. Aoki; M. Matsuda Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK Journal of Biological Chemistry, 285, 43, 33540-33548 , 285, 43, 33540-33548 Journal of Biological Chemistry, 285, 43, 33540-33548 2010/10/22 有 英語 公開
R. Misaki; M. Morimatsu; T. Uemura; S. Waguri; E. Miyoshi; N. Taniguchi; M. Matsuda; T. Taguchi R. Misaki; M. Morimatsu; T. Uemura; S. Waguri; E. Miyoshi; N. Taniguchi; M. Matsuda; T. Taguchi Palmitoylated ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis Palmitoylated ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis Journal of Cell Biology, 191, 1, 23-29 , 191, 1, 23-29 Journal of Cell Biology, 191, 1, 23-29 2010/10/04 有 英語 公開
S. Yoshiki; R. Matsunaga-Udagawa; K. Aoki; Y. Kamioka; E. Kiyokawa; M. Matsuda S. Yoshiki; R. Matsunaga-Udagawa; K. Aoki; Y. Kamioka; E. Kiyokawa; M. Matsuda Ras and calcium signaling pathways converge at Raf1 via the Shoc2 scaffold protein Ras and calcium signaling pathways converge at Raf1 via the Shoc2 scaffold protein Molecular Biology of the Cell, 21, 6, 1088-1096 , 21, 6, 1088-1096 Molecular Biology of the Cell, 21, 6, 1088-1096 2010/03/15 有 英語 公開
R. Matsunaga-Udagawa; Y. Fujita; S. Yoshiki; K. Terai; Y. Kamioka; E. Kiyokawa; K. Yugi; K. Aoki; M. Matsuda R. Matsunaga-Udagawa; Y. Fujita; S. Yoshiki; K. Terai; Y. Kamioka; E. Kiyokawa; K. Yugi; K. Aoki; M. Matsuda The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf Journal of Biological Chemistry, 285, 10, 7818-7826 , 285, 10, 7818-7826 Journal of Biological Chemistry, 285, 10, 7818-7826 2010/03/05 有 英語 公開
M.C. Parrini; J. Camonis; M. Matsuda; J. de Gunzburg M.C. Parrini; J. Camonis; M. Matsuda; J. de Gunzburg Dissecting activation of the PAK1 kinase at protrusions in living cells Dissecting activation of the PAK1 kinase at protrusions in living cells Journal of Biological Chemistry, 284, 36, 24133-24143 , 284, 36, 24133-24143 Journal of Biological Chemistry, 284, 36, 24133-24143 2009/09/04 有 英語 公開
E. Hirata; Y. Arakawa; M. Shirahata; M. Yamaguchi; Y. Kishi; T. Okada; J.A. Takahashi; M. Matsuda; N. Hashimoto E. Hirata; Y. Arakawa; M. Shirahata; M. Yamaguchi; Y. Kishi; T. Okada; J.A. Takahashi; M. Matsuda; N. Hashimoto Endogenous tenascin-C enhances glioblastoma invasion with reactive change of surrounding brain tissue Endogenous tenascin-C enhances glioblastoma invasion with reactive change of surrounding brain tissue Cancer Science, 100, 8, 1451-1459 , 100, 8, 1451-1459 Cancer Science, 100, 8, 1451-1459 2009/08 有 英語 公開
A. Elfenbein; J.M. Rhodes; J. Meller; M.A. Schwartz; M. Matsuda; M. Simons A. Elfenbein; J.M. Rhodes; J. Meller; M.A. Schwartz; M. Matsuda; M. Simons Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCα in a Rac1 activation pathway Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCα in a Rac1 activation pathway Journal of Cell Biology, 186, 1, 75-83 , 186, 1, 75-83 Journal of Cell Biology, 186, 1, 75-83 2009/07/13 有 英語 公開
E. Kiyokawa; M. Matsuda E. Kiyokawa; M. Matsuda Regulation of focal adhesion and cell migration by ANKRD28-DOCK180 interaction Regulation of focal adhesion and cell migration by ANKRD28-DOCK180 interaction Cell Adhesion and Migration, 3, 3, 281-284 , 3, 3, 281-284 Cell Adhesion and Migration, 3, 3, 281-284 2009/07 有 英語 公開
A. Lu; F. Tebar; B. Alvarez-Moya; C. López-Alcalaacute; M. Calvo; C. Enrich; N. Agell; T. Nakamura; M. Matsuda; O. Bachs A. Lu; F. Tebar; B. Alvarez-Moya; C. López-Alcalaacute; M. Calvo; C. Enrich; N. Agell; T. Nakamura; M. Matsuda; O. Bachs A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes Journal of Cell Biology, 184, 6, 863-879 , 184, 6, 863-879 Journal of Cell Biology, 184, 6, 863-879 2009/03/23 有 英語 公開
M. Higashi; C. Ishikawa; J. Yu; A. Toyoda; H. Kawana; K. Kurokawa; M. Matsuda; M. Kitagawa; K. Harigaya M. Higashi; C. Ishikawa; J. Yu; A. Toyoda; H. Kawana; K. Kurokawa; M. Matsuda; M. Kitagawa; K. Harigaya Human mena associates with Rac1 small GTPase in glioblastoma cell lines Human mena associates with Rac1 small GTPase in glioblastoma cell lines PLoS ONE, 4, 3 , 4, 3 PLoS ONE, 4, 3 2009/03/11 有 英語 公開
M. Tachibana; E. Kiyokawa; S. Hara; S.-i. Iemura; T. Natsume; T. Manabe; M. Matsuda M. Tachibana; E. Kiyokawa; S. Hara; S.-i. Iemura; T. Natsume; T. Manabe; M. Matsuda Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, promotes cell migration by regulating focal adhesion formation Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, promotes cell migration by regulating focal adhesion formation Experimental Cell Research, 315, 5, 863-876 , 315, 5, 863-876 Experimental Cell Research, 315, 5, 863-876 2009/03/10 有 英語 公開
K. Aoki; M. Matsuda K. Aoki; M. Matsuda Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors. Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors. Nature protocols, 4, 11, 1623-1631 , 4, 11, 1623-1631 Nature protocols, 4, 11, 1623-1631 2009 有 英語 公開
T. Nakamura; M. Kitano; M. Nakaya; S. Nagata; M. Matsuda T. Nakamura; M. Kitano; M. Nakaya; S. Nagata; M. Matsuda [Activity change of small GTPases Rac1 and Rab5 during phagocytosis]. [Activity change of small GTPases Rac1 and Rab5 during phagocytosis]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 8 Suppl, 1114-1118 , 54, 8 Suppl, 1114-1118 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 8 Suppl, 1114-1118 2009 有 英語 公開
J. Dauwels; Y. Tsukada; Y. Sakumura; S. Ishii; K. Aoki; T. Nakamura; M. Matsuda; F. Vialatte; A. Cichocki J. Dauwels; Y. Tsukada; Y. Sakumura; S. Ishii; K. Aoki; T. Nakamura; M. Matsuda; F. Vialatte; A. Cichocki On the synchrony of morphological and molecular signaling events in cell migration On the synchrony of morphological and molecular signaling events in cell migration Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 5506 LNCS, PART 1, 469-477 , 5506 LNCS, PART 1, 469-477 Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 5506 LNCS, PART 1, 469-477 2009 有 英語 公開
Y. Tsukada; K. Aoki; T. Nakamura; Y. Sakumura; M. Matsuda; S. Ishii Y. Tsukada; K. Aoki; T. Nakamura; Y. Sakumura; M. Matsuda; S. Ishii Quantification of local morphodynamics and local GTPase activity by edge evolution tracking Quantification of local morphodynamics and local GTPase activity by edge evolution tracking PLoS Computational Biology, 4, 11 , 4, 11 PLoS Computational Biology, 4, 11 2008/11 有 英語 公開
K. Aoki; E. Kiyokawa; T. Nakamura; M. Matsuda K. Aoki; E. Kiyokawa; T. Nakamura; M. Matsuda Visualization of growth signal transduction cascades in living cells with genetically encoded probes based on Förster resonance energy transfer Visualization of growth signal transduction cascades in living cells with genetically encoded probes based on Förster resonance energy transfer Philosophical Transactions of the Royal Society B: Biological Sciences, 363, 1500, 2143-2151 , 363, 1500, 2143-2151 Philosophical Transactions of the Royal Society B: Biological Sciences, 363, 1500, 2143-2151 2008/06/27 有 英語 公開
N. Omi; E. Kiyokawa; M. Matsuda; K. Kinoshita; S. Yamada; K. Yamada; Y. Matsushima; Y. Wang; J. Kawai; M. Suzuki; Y. Hayashizaki; H. Hiai N. Omi; E. Kiyokawa; M. Matsuda; K. Kinoshita; S. Yamada; K. Yamada; Y. Matsushima; Y. Wang; J. Kawai; M. Suzuki; Y. Hayashizaki; H. Hiai Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse Experimental Eye Research, 86, 5, 828-834 , 86, 5, 828-834 Experimental Eye Research, 86, 5, 828-834 2008 有 英語 公開
M. Kitano; M. Nakaya; T. Nakamura; S. Nagata; M. Matsuda M. Kitano; M. Nakaya; T. Nakamura; S. Nagata; M. Matsuda Imaging of Rab5 activity identifies essential regulators for phagosome maturation Imaging of Rab5 activity identifies essential regulators for phagosome maturation Nature, 453, 7192, 241-245 , 453, 7192, 241-245 Nature, 453, 7192, 241-245 2008 有 英語 公開
R.E. Itoh; E. Kiyokawa; K. Aoki; T. Nishioka; T. Akiyama; M. Matsuda R.E. Itoh; E. Kiyokawa; K. Aoki; T. Nishioka; T. Akiyama; M. Matsuda Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF Journal of Cell Science, 121, 16, 2635-2642 , 121, 16, 2635-2642 Journal of Cell Science, 121, 16, 2635-2642 2008 有 英語 公開
S. Hara; E. Kiyokawa; S.-I. Iemura; T. Natsume; T. Wassmer; P.J. Cullen; H. Hiai; M. Matsuda S. Hara; E. Kiyokawa; S.-I. Iemura; T. Natsume; T. Wassmer; P.J. Cullen; H. Hiai; M. Matsuda The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport Molecular Biology of the Cell, 19, 9, 3823-3835 , 19, 9, 3823-3835 Molecular Biology of the Cell, 19, 9, 3823-3835 2008 有 英語 公開
T. Nakamura; K. Aoki; M. Matsuda T. Nakamura; K. Aoki; M. Matsuda FRET imaging and in silico simulation: Analysis of the signaling network of nerve growth factor-induced neuritogenesis FRET imaging and in silico simulation: Analysis of the signaling network of nerve growth factor-induced neuritogenesis Brain Cell Biology, 36, 1-4, 19-30 , 36, 1-4, 19-30 Brain Cell Biology, 36, 1-4, 19-30 2008 有 英語 公開
T. Nishioka; K. Aoki; K. Hikake; H. Yoshizaki; E. Kiyokawa; M. Matsuda T. Nishioka; K. Aoki; K. Hikake; H. Yoshizaki; E. Kiyokawa; M. Matsuda Rapid turnover rate of phosphoinositides at the front of migrating MDCK cells Rapid turnover rate of phosphoinositides at the front of migrating MDCK cells Molecular Biology of the Cell, 19, 10, 4213-4223 , 19, 10, 4213-4223 Molecular Biology of the Cell, 19, 10, 4213-4223 2008 有 英語 公開
K. Aoki; T. Nakamura; T. Inoue; T. Meyer; M. Matsuda K. Aoki; T. Nakamura; T. Inoue; T. Meyer; M. Matsuda An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells Journal of Cell Biology, 177, 5, 817-827 , 177, 5, 817-827 Journal of Cell Biology, 177, 5, 817-827 2007/06/04 有 英語 公開
N. Uawonggul; S. Thammasirirak; A. Chaveerach; T. Arkaravichien; W. Bunyatratchata; W. Ruangjirachuporn; P. Jearranaiprepame; T. Nakamura; M. Matsuda; M. Kobayashi; S. Hattori; S. Daduang N. Uawonggul; S. Thammasirirak; A. Chaveerach; T. Arkaravichien; W. Bunyatratchata; W. Ruangjirachuporn; P. Jearranaiprepame; T. Nakamura; M. Matsuda; M. Kobayashi; S. Hattori; S. Daduang Purification and characterization of Heteroscorpine-1 (HS-1) toxin from Heterometrus laoticus scorpion venom Purification and characterization of Heteroscorpine-1 (HS-1) toxin from Heterometrus laoticus scorpion venom Toxicon, 49, 1, 19-29 , 49, 1, 19-29 Toxicon, 49, 1, 19-29 2007 有 英語 公開
H. Yoshizaki; N. Mochizuki; Y. Gotoh; M. Matsuda H. Yoshizaki; N. Mochizuki; Y. Gotoh; M. Matsuda Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation Molecular Biology of the Cell, 18, 1, 119-128 , 18, 1, 119-128 Molecular Biology of the Cell, 18, 1, 119-128 2007 有 英語 公開
T. Fukano; A. Sawano; Y. Ohba; M. Matsuda; A. Miyawaki T. Fukano; A. Sawano; Y. Ohba; M. Matsuda; A. Miyawaki Differential ras activation between caveolae/raft and non-raft microdomains Differential ras activation between caveolae/raft and non-raft microdomains Cell Structure and Function, 32, 1, 9-15 , 32, 1, 9-15 Cell Structure and Function, 32, 1, 9-15 2007 有 英語 公開
A. Takaya; T. Kamio; M. Masuda; N. Mochizuki; H. Sawa; M. Sato; K. Nagashima; A. Mizutani; A. Matsuno; E. Kiyokawa; M. Matsuda A. Takaya; T. Kamio; M. Masuda; N. Mochizuki; H. Sawa; M. Sato; K. Nagashima; A. Mizutani; A. Matsuno; E. Kiyokawa; M. Matsuda R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes Molecular Biology of the Cell, 18, 5, 1850-1860 , 18, 5, 1850-1860 Molecular Biology of the Cell, 18, 5, 1850-1860 2007 有 英語 公開
S. Hisata; T. Sakisaka; T. Baba; T. Yamada; K. Aoki; M. Matsuda; Y. Takai S. Hisata; T. Sakisaka; T. Baba; T. Yamada; K. Aoki; M. Matsuda; Y. Takai Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth Journal of Cell Biology, 178, 5, 843-860 , 178, 5, 843-860 Journal of Cell Biology, 178, 5, 843-860 2007 有 英語 公開
T. Nakamura; K. Kurokawa; E. Kiyokawa; M. Matsuda T. Nakamura; K. Kurokawa; E. Kiyokawa; M. Matsuda Analysis of the spatiotemporal activation of Rho GTPases using raichu probes Analysis of the spatiotemporal activation of Rho GTPases using raichu probes Methods in Enzymology, 406, 315-332 , 406, 315-332 Methods in Enzymology, 406, 315-332 2006 有 英語 公開
E. Kiyokawa; S. Hara; T. Nakamura; M. Matsuda E. Kiyokawa; S. Hara; T. Nakamura; M. Matsuda Fluorescence (Förster) resonance energy transfer imaging of oncogene activity in living cells Fluorescence (Förster) resonance energy transfer imaging of oncogene activity in living cells Cancer Science, 97, 1, 8-15 , 97, 1, 8-15 Cancer Science, 97, 1, 8-15 2006 有 英語 公開
A. Fujioka; K. Terai; R.E. Itoh; K. Aoki; T. Nakamura; S. Kuroda; E. Nishida; M. Matsuda A. Fujioka; K. Terai; R.E. Itoh; K. Aoki; T. Nakamura; S. Kuroda; E. Nishida; M. Matsuda Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes Journal of Biological Chemistry, 281, 13, 8917-8926 , 281, 13, 8917-8926 Journal of Biological Chemistry, 281, 13, 8917-8926 2006 有 英語 公開
K. Terai; M. Matsuda K. Terai; M. Matsuda The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf EMBO Journal, 25, 15, 3556-3564 , 25, 15, 3556-3564 EMBO Journal, 25, 15, 3556-3564 2006 有 英語 公開
K. Kawase; T. Nakamura; A. Takaya; K. Aoki; K. Namikawa; H. Kiyama; S. Inagaki; H. Takemoto; A.R. Saltiel; M. Matsuda K. Kawase; T. Nakamura; A. Takaya; K. Aoki; K. Namikawa; H. Kiyama; S. Inagaki; H. Takemoto; A.R. Saltiel; M. Matsuda GTP Hydrolysis by the Rho Family GTPase TC10 Promotes Exocytic Vesicle Fusion GTP Hydrolysis by the Rho Family GTPase TC10 Promotes Exocytic Vesicle Fusion Developmental Cell, 11, 3, 411-421 , 11, 3, 411-421 Developmental Cell, 11, 3, 411-421 2006 有 英語 公開
N. Yamana; Y. Arakawa; T. Nishino; K. Kurokawa; M. Tanji; R.E. Itoh; J. Monypenny; T. Ishizaki; H. Bito; K. Nozaki; N. Hashimoto; M. Matsuda; S. Narumiya N. Yamana; Y. Arakawa; T. Nishino; K. Kurokawa; M. Tanji; R.E. Itoh; J. Monypenny; T. Ishizaki; H. Bito; K. Nozaki; N. Hashimoto; M. Matsuda; S. Narumiya The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src Molecular and Cellular Biology, 26, 18, 6844-6858 , 26, 18, 6844-6858 Molecular and Cellular Biology, 26, 18, 6844-6858 2006 有 英語 公開
H. Yoshizaki; K. Aoki; T. Nakamura; M. Matsuda H. Yoshizaki; K. Aoki; T. Nakamura; M. Matsuda Regulation of RalA GTPase by phosphatidylinositol 3-kinase as visualized by FRET probes Regulation of RalA GTPase by phosphatidylinositol 3-kinase as visualized by FRET probes Biochemical Society Transactions, 34, 5, 851-854 , 34, 5, 851-854 Biochemical Society Transactions, 34, 5, 851-854 2006 有 英語 公開
H. Yoshizak; N. Mochizuki; M. Matsuda H. Yoshizak; N. Mochizuki; M. Matsuda Activity of Rho-family G proteins as visualized with FRET-based probes Activity of Rho-family G proteins as visualized with FRET-based probes Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme., 51, 6 Suppl, 699-704 , 51, 6 Suppl, 699-704 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme., 51, 6 Suppl, 699-704 2006 有 英語 公開
K. Aoki; T. Nakamura; K. Fujikawa; M. Matsuda K. Aoki; T. Nakamura; K. Fujikawa; M. Matsuda Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells Molecular Biology of the Cell, 16, 5, 2207-2217 , 16, 5, 2207-2217 Molecular Biology of the Cell, 16, 5, 2207-2217 2005/05 有 英語 公開
K. Terai; M. Matsuda K. Terai; M. Matsuda Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase EMBO Reports, 6, 3, 251-255 , 6, 3, 251-255 EMBO Reports, 6, 3, 251-255 2005 有 英語 公開
R.E. Itoh; K. Kurokawa; A. Fujioka; A. Sharma; B.J. Mayer; M. Matsuda R.E. Itoh; K. Kurokawa; A. Fujioka; A. Sharma; B.J. Mayer; M. Matsuda A FRET-based probe for epidermal growth factor receptor bound non-covalently to a pair of synthetic amphipathic helixes A FRET-based probe for epidermal growth factor receptor bound non-covalently to a pair of synthetic amphipathic helixes Experimental Cell Research, 307, 1, 142-152 , 307, 1, 142-152 Experimental Cell Research, 307, 1, 142-152 2005 有 英語 公開
T. Fukuyama; H. Ogita; T. Kawakatsu; T. Fukuhara; T. Yamada; T. Sato; K. Shimizu; T. Nakamura; M. Matsuda; Y. Takai T. Fukuyama; H. Ogita; T. Kawakatsu; T. Fukuhara; T. Yamada; T. Sato; K. Shimizu; T. Nakamura; M. Matsuda; Y. Takai Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions Journal of Biological Chemistry, 280, 1, 815-825 , 280, 1, 815-825 Journal of Biological Chemistry, 280, 1, 815-825 2005 有 英語 公開
S. Uematsu; S. Sato; M. Yamamoto; T. Hirotani; H. Kato; F. Takeshita; M. Matsuda; C. Coban; K.J. Ishii; T. Kawai; O. Takeuchi; S. Akira S. Uematsu; S. Sato; M. Yamamoto; T. Hirotani; H. Kato; F. Takeshita; M. Matsuda; C. Coban; K.J. Ishii; T. Kawai; O. Takeuchi; S. Akira Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction Journal of Experimental Medicine, 201, 6, 915-923 , 201, 6, 915-923 Journal of Experimental Medicine, 201, 6, 915-923 2005 有 英語 公開
K. Kurokawa; T. Nakamura; K. Aoki; M. Matsuda K. Kurokawa; T. Nakamura; K. Aoki; M. Matsuda Mechanism and role of localized activation of Rho-family GTPases in growth factor-stimulated fibroblasts and neuronal cells Mechanism and role of localized activation of Rho-family GTPases in growth factor-stimulated fibroblasts and neuronal cells Biochemical Society Transactions, 33, 4, 631-634 , 33, 4, 631-634 Biochemical Society Transactions, 33, 4, 631-634 2005 有 英語 公開
M.C. Parrini; M. Matsuda; J. De Gunzburg M.C. Parrini; M. Matsuda; J. De Gunzburg Spatiotemporal regulation of the Pak1 kinase Spatiotemporal regulation of the Pak1 kinase Biochemical Society Transactions, 33, 4, 646-648 , 33, 4, 646-648 Biochemical Society Transactions, 33, 4, 646-648 2005 有 英語 公開
K. Kurokawa; M. Matsuda K. Kurokawa; M. Matsuda Localized RhoA activation as a requirement for the induction of membrane ruffling Localized RhoA activation as a requirement for the induction of membrane ruffling Molecular Biology of the Cell, 16, 9, 4294-4303 , 16, 9, 4294-4303 Molecular Biology of the Cell, 16, 9, 4294-4303 2005 有 英語 公開
T. Nakamura; K. Aoki; M. Matsuda T. Nakamura; K. Aoki; M. Matsuda FRET imaging in nerve growth cones reveals a high level of RhoA activity within the peripheral domain FRET imaging in nerve growth cones reveals a high level of RhoA activity within the peripheral domain Molecular Brain Research, 139, 2, 277-287 , 139, 2, 277-287 Molecular Brain Research, 139, 2, 277-287 2005 有 英語 公開
T. Nakamura; K. Aoki; M. Matsuda T. Nakamura; K. Aoki; M. Matsuda Monitoring spatio-temporal regulation of Ras and Rho GTPases with GFP-based FRET probes Monitoring spatio-temporal regulation of Ras and Rho GTPases with GFP-based FRET probes Methods, 37, 2, 146-153 , 37, 2, 146-153 Methods, 37, 2, 146-153 2005 有 英語 公開
K. Aoki; T. Nakamura; M. Matsuda K. Aoki; T. Nakamura; M. Matsuda Spatio-temporal Regulation of Racl and Cdc42 Activity during Nerve Growth Factor-induced Neurite Outgrowth in PC12 Cells Spatio-temporal Regulation of Racl and Cdc42 Activity during Nerve Growth Factor-induced Neurite Outgrowth in PC12 Cells Journal of Biological Chemistry, 279, 1, 713-719 , 279, 1, 713-719 Journal of Biological Chemistry, 279, 1, 713-719 2004/01/02 有 英語 公開
T. Hoshino; K. Shimizu; T. Honda; T. Kawakatsu; T. Fukuyama; T. Nakamura; M. Matsuda; Y. Takai T. Hoshino; K. Shimizu; T. Honda; T. Kawakatsu; T. Fukuyama; T. Nakamura; M. Matsuda; Y. Takai A Novel Role of Nectins in Inhibition of the E-Cadherin-induced Activation of Rac and Formation of Cell-Cell Adherens Junctions A Novel Role of Nectins in Inhibition of the E-Cadherin-induced Activation of Rac and Formation of Cell-Cell Adherens Junctions Molecular Biology of the Cell, 15, 3, 1077-1088 , 15, 3, 1077-1088 Molecular Biology of the Cell, 15, 3, 1077-1088 2004 有 英語 公開
K. Kurokawa; R.E. Itoh; H. Yoshizaki; Y. Ohba; T. Nakamura; M. Matsuda K. Kurokawa; R.E. Itoh; H. Yoshizaki; Y. Ohba; T. Nakamura; M. Matsuda Coactivation of Rac1 and Cdc42 at Lamellipodia and Membrane Ruffles Induced by Epidermal Growth Factor Coactivation of Rac1 and Cdc42 at Lamellipodia and Membrane Ruffles Induced by Epidermal Growth Factor Molecular Biology of the Cell, 15, 3, 1003-1010 , 15, 3, 1003-1010 Molecular Biology of the Cell, 15, 3, 1003-1010 2004 有 英語 公開
K. Kurokawa; A. Takaya; K. Terai; A. Fujioka; M. Matsuda K. Kurokawa; A. Takaya; K. Terai; A. Fujioka; M. Matsuda Visualizing the signal transduction pathways in living cells with GFP-based FRET probes Visualizing the signal transduction pathways in living cells with GFP-based FRET probes Acta Histochemica et Cytochemica, 37, 6, 347-355 , 37, 6, 347-355 Acta Histochemica et Cytochemica, 37, 6, 347-355 2004 有 英語 公開
A. Takaya; Y. Ohba; K. Kurokawa; M. Matsuda A. Takaya; Y. Ohba; K. Kurokawa; M. Matsuda Ra1A activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney cells Ra1A activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney cells Molecular Biology of the Cell, 15, 6, 2549-2557 , 15, 6, 2549-2557 Molecular Biology of the Cell, 15, 6, 2549-2557 2004 有 英語 公開
H. Yano; Y. Mazaki; K. Kurokawa; S.K. Hanks; M. Matsuda; H. Sabe H. Yano; Y. Mazaki; K. Kurokawa; S.K. Hanks; M. Matsuda; H. Sabe Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion Journal of Cell Biology, 166, 2, 283-295 , 166, 2, 283-295 Journal of Cell Biology, 166, 2, 283-295 2004 有 英語 公開
Y. Kamioka; S. Fukuhara; H. Sawa; K. Nagashima; M. Masuda; M. Matsuda; N. Mochizuki Y. Kamioka; S. Fukuhara; H. Sawa; K. Nagashima; M. Masuda; M. Matsuda; N. Mochizuki A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis Journal of Biological Chemistry, 279, 38, 40091-40099 , 279, 38, 40091-40099 Journal of Biological Chemistry, 279, 38, 40091-40099 2004 有 英語 公開
C. Miyagi; S. Yamashita; Y. Ohba; H. Yoshizaki; M. Matsuda; T. Hirano C. Miyagi; S. Yamashita; Y. Ohba; H. Yoshizaki; M. Matsuda; T. Hirano STATS noncell-autonomously controls planar cell polarity during zebrafish convergence and extension STATS noncell-autonomously controls planar cell polarity during zebrafish convergence and extension Journal of Cell Biology, 166, 7, 975-981 , 166, 7, 975-981 Journal of Cell Biology, 166, 7, 975-981 2004 有 英語 公開
T. Kawai; S. Sato; K.J. Ishii; C. Coban; H. Hemmi; M. Yamamoto; K. Terai; M. Matsuda; J.-I. Inoue; S. Uematsu; O. Takeuchi; S. Akira T. Kawai; S. Sato; K.J. Ishii; C. Coban; H. Hemmi; M. Yamamoto; K. Terai; M. Matsuda; J.-I. Inoue; S. Uematsu; O. Takeuchi; S. Akira Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 Nature Immunology, 5, 10, 1061-1068 , 5, 10, 1061-1068 Nature Immunology, 5, 10, 1061-1068 2004 有 英語 公開
H. Yoshizaki; Y. Ohba; M.-C. Parrini; N.G. Dulyaninova; A.R. Bresnick; N. Mochizuki; M. Matsuda H. Yoshizaki; Y. Ohba; M.-C. Parrini; N.G. Dulyaninova; A.R. Bresnick; N. Mochizuki; M. Matsuda Cell type-specific regulation of RhoA activity during cytokinesis Cell type-specific regulation of RhoA activity during cytokinesis Journal of Biological Chemistry, 279, 43, 44756-44762 , 279, 43, 44756-44762 Journal of Biological Chemistry, 279, 43, 44756-44762 2004 有 英語 公開
Y. Ohba; K. Kurokawa; M. Matsuda Y. Ohba; K. Kurokawa; M. Matsuda Mechanism of the spatio-temporal regulation of Ras and Rap1 Mechanism of the spatio-temporal regulation of Ras and Rap1 EMBO Journal, 22, 4, 859-869 , 22, 4, 859-869 EMBO Journal, 22, 4, 859-869 2003 有 英語 公開
T. Honda; K. Shimizu; T. Kawakatsu; A. Fukuhara; K. Irie; T. Nakamura; M. Matsuda; Y. Takai T. Honda; K. Shimizu; T. Kawakatsu; A. Fukuhara; K. Irie; T. Nakamura; M. Matsuda; Y. Takai Cdc42 and Rac small G proteins activated by trans-interactions of nectins are involved in activation of c-Jun N-terminal kinase, but not in association of nectins and cadherin to form adherens junctions, in fibroblasts Cdc42 and Rac small G proteins activated by trans-interactions of nectins are involved in activation of c-Jun N-terminal kinase, but not in association of nectins and cadherin to form adherens junctions, in fibroblasts Genes to Cells, 8, 5, 481-491 , 8, 5, 481-491 Genes to Cells, 8, 5, 481-491 2003 有 英語 公開
H. Yoshizaki; Y. Ohba; K. Kurokawa; R.E. Itoh; T. Nakamura; N. Mochizuki; K. Nagashima; M. Matsuda H. Yoshizaki; Y. Ohba; K. Kurokawa; R.E. Itoh; T. Nakamura; N. Mochizuki; K. Nagashima; M. Matsuda Activity of Rho-family GTPases during cell division as visualized with FRET-based probes Activity of Rho-family GTPases during cell division as visualized with FRET-based probes Journal of Cell Biology, 162, 2, 223-232 , 162, 2, 223-232 Journal of Cell Biology, 162, 2, 223-232 2003 有 英語 公開
Y. Murakami; H. Fukazawa; T. Kobatake; S. Yamagoe; Y. Takebe; M. Tobiume; M. Matsuda; Y. Uehara Y. Murakami; H. Fukazawa; T. Kobatake; S. Yamagoe; Y. Takebe; M. Tobiume; M. Matsuda; Y. Uehara A mammalian two-hybrid screening system for inhibitors of interaction between HIV Nef and the cellular tyrosine kinase Hck A mammalian two-hybrid screening system for inhibitors of interaction between HIV Nef and the cellular tyrosine kinase Hck Antiviral Research, 55, 1, 161-168 , 55, 1, 161-168 Antiviral Research, 55, 1, 161-168 2002 有 英語 公開
M. Tobiume; M. Takahoko; T. Yamada; M. Tatsumi; A. Iwamoto; M. Matsuda M. Tobiume; M. Takahoko; T. Yamada; M. Tatsumi; A. Iwamoto; M. Matsuda Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 Nef from Japanese long-term nonprogressors Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 Nef from Japanese long-term nonprogressors Journal of Virology, 76, 12, 5959-5965 , 76, 12, 5959-5965 Journal of Virology, 76, 12, 5959-5965 2002 有 英語 公開
A. Sawano; S. Takayama; M. Matsuda; A. Miyawaki A. Sawano; S. Takayama; M. Matsuda; A. Miyawaki Lateral propagation of EGF signaling after local stimulation is dependent on receptor density Lateral propagation of EGF signaling after local stimulation is dependent on receptor density Developmental Cell, 3, 2, 245-257 , 3, 2, 245-257 Developmental Cell, 3, 2, 245-257 2002 有 英語 公開
R.E. Itoh; K. Kurokawa; Y. Ohba; H. Yoshizaki; N. Mochizuki; M. Matsuda R.E. Itoh; K. Kurokawa; Y. Ohba; H. Yoshizaki; N. Mochizuki; M. Matsuda Activation of Rac and Cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells Activation of Rac and Cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells Molecular and Cellular Biology, 22, 18, 6582-6591 , 22, 18, 6582-6591 Molecular and Cellular Biology, 22, 18, 6582-6591 2002 有 英語 公開
K.-I. Nagashima; A. Endo; H. Ogita; A. Kawana; A. Yamagishi; A. Kitabatake; M. Matsuda; N. Mochizuki K.-I. Nagashima; A. Endo; H. Ogita; A. Kawana; A. Yamagishi; A. Kitabatake; M. Matsuda; N. Mochizuki Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells Molecular Biology of the Cell, 13, 12, 4231-4242 , 13, 12, 4231-4242 Molecular Biology of the Cell, 13, 12, 4231-4242 2002 有 英語 公開
A. Endo; K.-I. Nagashima; H. Kurose; S. Mochizuki; M. Matsuda; N. Mochizuki A. Endo; K.-I. Nagashima; H. Kurose; S. Mochizuki; M. Matsuda; N. Mochizuki Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII Journal of Biological Chemistry, 277, 26, 23747-23754 , 277, 26, 23747-23754 Journal of Biological Chemistry, 277, 26, 23747-23754 2002 有 英語 公開
A. Sakakibara; Y. Ohba; K. Kurokawa; M. Matsuda; S. Hattori A. Sakakibara; Y. Ohba; K. Kurokawa; M. Matsuda; S. Hattori Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation Journal of Cell Science, 115, 24, 4915-4924 , 115, 24, 4915-4924 Journal of Cell Science, 115, 24, 4915-4924 2002 有 英語 公開
Y. Ohba; K. Ikuta; A. Ogura; J. Matsuda; N. Mochizuki; K. Nagashima; K. Kurokawa; B.J. Mayer; K. Maki; J.-I. Miyazaki; M. Matsuda Y. Ohba; K. Ikuta; A. Ogura; J. Matsuda; N. Mochizuki; K. Nagashima; K. Kurokawa; B.J. Mayer; K. Maki; J.-I. Miyazaki; M. Matsuda Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis EMBO Journal, 20, 13, 3333-3341 , 20, 13, 3333-3341 EMBO Journal, 20, 13, 3333-3341 2001/07/02 有 英語 公開
M. Tobiume; K. Tokunaga; E. Kiyokawa; M. Takahoko; N. Mochizuki; M. Tatsumi; M. Matsuda M. Tobiume; K. Tokunaga; E. Kiyokawa; M. Takahoko; N. Mochizuki; M. Tatsumi; M. Matsuda Requirement of Nef for HIV-1 infectivity is biased by the expression levels of Env in the virus-producing cells and CD4 in the target cells Requirement of Nef for HIV-1 infectivity is biased by the expression levels of Env in the virus-producing cells and CD4 in the target cells Archives of Virology, 146, 9, 1739-1751 , 146, 9, 1739-1751 Archives of Virology, 146, 9, 1739-1751 2001 有 英語 公開
M. Takahoko; M. Tobiume; K. Ishikawa; W. Ampofo; N. Yamamoto; M. Matsuda; M. Tatsumi M. Takahoko; M. Tobiume; K. Ishikawa; W. Ampofo; N. Yamamoto; M. Matsuda; M. Tatsumi Infectious DNA clone of HIV type 1 A/G recombinant (CRF02_AG) replicable in peripheral blood mononuclear cells Infectious DNA clone of HIV type 1 A/G recombinant (CRF02_AG) replicable in peripheral blood mononuclear cells AIDS Research and Human Retroviruses, 17, 11, 1083-1087 , 17, 11, 1083-1087 AIDS Research and Human Retroviruses, 17, 11, 1083-1087 2001 有 英語 公開
M. Tobiume; M. Takahoko; M. Tatsumi; M. Matsuda M. Tobiume; M. Takahoko; M. Tatsumi; M. Matsuda Establishment of a MAGI-derived indicator cell line that detects the Nef enhancement of HIV-1 infectivity with high sensitivity Establishment of a MAGI-derived indicator cell line that detects the Nef enhancement of HIV-1 infectivity with high sensitivity Journal of Virological Methods, 97, 1-2, 151-158 , 97, 1-2, 151-158 Journal of Virological Methods, 97, 1-2, 151-158 2001 有 英語 公開
S. Kobayashi; T. Shirai; E. Kiyokawa; N. Mochizuki; M. Matsuda; Y. Fukui S. Kobayashi; T. Shirai; E. Kiyokawa; N. Mochizuki; M. Matsuda; Y. Fukui Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P<sub>3</sub> Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P<sub>3</sub> Biochemical Journal, 354, 1, 73-78 , 354, 1, 73-78 Biochemical Journal, 354, 1, 73-78 2001 有 英語 公開
K. Kurokawa; N. Mochizuki; Y. Ohba; H. Mizuno; A. Miyawaki; M. Matsuda K. Kurokawa; N. Mochizuki; Y. Ohba; H. Mizuno; A. Miyawaki; M. Matsuda A Pair of Fluorescent Resonance Energy Transfer-based Probes for Tyrosine Phosphorylation of the CrkII Adaptor Protein in Vivo A Pair of Fluorescent Resonance Energy Transfer-based Probes for Tyrosine Phosphorylation of the CrkII Adaptor Protein in Vivo Journal of Biological Chemistry, 276, 33, 31305-31310 , 276, 33, 31305-31310 Journal of Biological Chemistry, 276, 33, 31305-31310 2001 有 英語 公開
N. Mochizuki; S. Yamashita; K. Kurokawa; Y. Ohba; T. Nagai; A. Miyawaki; M. Matsuda N. Mochizuki; S. Yamashita; K. Kurokawa; Y. Ohba; T. Nagai; A. Miyawaki; M. Matsuda Spatio-temporal images of growth-factor-induced activation of Ras and Rap1 Spatio-temporal images of growth-factor-induced activation of Ras and Rap1 Nature, 411, 6841, 1065-1068 , 411, 6841, 1065-1068 Nature, 411, 6841, 1065-1068 2001 有 英語 公開
Y. Ohba; N. Mochizuki; K. Matsuo; S. Yamashita; M. Nakaya; Y. Hashimoto; M. Hamaguchi; T. Kurata; K. Nagashima; M. Matsuda Y. Ohba; N. Mochizuki; K. Matsuo; S. Yamashita; M. Nakaya; Y. Hashimoto; M. Hamaguchi; T. Kurata; K. Nagashima; M. Matsuda Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade Molecular and Cellular Biology, 20, 16, 6074-6083 , 20, 16, 6074-6083 Molecular and Cellular Biology, 20, 16, 6074-6083 2000 有 英語 公開
T. Matsumoto; K. Yokote; A. Take; M. Takemoto; S. Asaumi; Y. Hashimoto; M. Matsuda; Y. Saito; S. Mori T. Matsumoto; K. Yokote; A. Take; M. Takemoto; S. Asaumi; Y. Hashimoto; M. Matsuda; Y. Saito; S. Mori Differential interaction of CrkII adaptor protein with platelet-derived growth factor α- and β-receptors is determined by its internal tyrosine phosphorylation Differential interaction of CrkII adaptor protein with platelet-derived growth factor α- and β-receptors is determined by its internal tyrosine phosphorylation Biochemical and Biophysical Research Communications, 270, 1, 28-33 , 270, 1, 28-33 Biochemical and Biophysical Research Communications, 270, 1, 28-33 2000 有 英語 公開
S. Yamashita; N. Mochizuki; Y. Ohba; M. Tobiume; Y. Okada; H. Sawa; K. Nagashima; M. Matsuda S. Yamashita; N. Mochizuki; Y. Ohba; M. Tobiume; Y. Okada; H. Sawa; K. Nagashima; M. Matsuda CalDAG-GEFIII activation of Ras, R-Ras, and Rap1 CalDAG-GEFIII activation of Ras, R-Ras, and Rap1 Journal of Biological Chemistry, 275, 33, 25488-25493 , 275, 33, 25488-25493 Journal of Biological Chemistry, 275, 33, 25488-25493 2000 有 英語 公開
N. Mochizuki; Y. Ohba; S. Kobayashi; N. Otsuka; A.M. Graybiel; S. Tanaka; M. Matsuda N. Mochizuki; Y. Ohba; S. Kobayashi; N. Otsuka; A.M. Graybiel; S. Tanaka; M. Matsuda Crk activation of JNK via C3G and R-Ras Crk activation of JNK via C3G and R-Ras Journal of Biological Chemistry, 275, 17, 12667-12671 , 275, 17, 12667-12671 Journal of Biological Chemistry, 275, 17, 12667-12671 2000 有 英語 公開
Y. Ohba; N. Mochizuki; S. Yamashita; A.M. Chan; J.W. Schrader; S. Hattori; K. Nagashima; M. Matsuda Y. Ohba; N. Mochizuki; S. Yamashita; A.M. Chan; J.W. Schrader; S. Hattori; K. Nagashima; M. Matsuda Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3 Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3 Journal of Biological Chemistry, 275, 26, 20020-20026 , 275, 26, 20020-20026 Journal of Biological Chemistry, 275, 26, 20020-20026 2000 有 英語 公開
H. Nishihara; S. Kobayashi; Y. Hashimoto; F. Ohba; N. Mochizuki; T. Kurata; K. Nagashima; M. Matsuda H. Nishihara; S. Kobayashi; Y. Hashimoto; F. Ohba; N. Mochizuki; T. Kurata; K. Nagashima; M. Matsuda Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins Biochimica et Biophysica Acta - Molecular Cell Research, 1452, 2, 179-187 , 1452, 2, 179-187 Biochimica et Biophysica Acta - Molecular Cell Research, 1452, 2, 179-187 1999 有 英語 公開
N. Mochizuki; N. Otsuka; K. Matsuo; T. Shiino; A. Kojima; T. Kurata; K. Sakai; N. Yamamoto; S. Isomura; T.N. Dhole; Y. Takebe; M. Matsuda; M. Tatsumi N. Mochizuki; N. Otsuka; K. Matsuo; T. Shiino; A. Kojima; T. Kurata; K. Sakai; N. Yamamoto; S. Isomura; T.N. Dhole; Y. Takebe; M. Matsuda; M. Tatsumi An infectious DNA clone of HIV type 1 subtype C An infectious DNA clone of HIV type 1 subtype C AIDS Research and Human Retroviruses, 15, 14, 1321-1324 , 15, 14, 1321-1324 AIDS Research and Human Retroviruses, 15, 14, 1321-1324 1999 有 英語 公開
K. Tokunaga; K. Ikuta; A. Adachi; M. Matsuda; T. Kurata; A. Kojima K. Tokunaga; K. Ikuta; A. Adachi; M. Matsuda; T. Kurata; A. Kojima The cellular kinase binding motifs (PxxP and RR) in human immunodeficiency virus type 1 Nef protein are dispensable for producer-cell- dependent enhancement of viral entry The cellular kinase binding motifs (PxxP and RR) in human immunodeficiency virus type 1 Nef protein are dispensable for producer-cell- dependent enhancement of viral entry Virology, 257, 2, 285-289 , 257, 2, 285-289 Virology, 257, 2, 285-289 1999 有 英語 公開
T. Ichiba; Y. Hashimoto; M. Nakaya; Y. Kuraishi; S. Tanaka; T. Kurata; N. Mochizuki; M. Matsuda T. Ichiba; Y. Hashimoto; M. Nakaya; Y. Kuraishi; S. Tanaka; T. Kurata; N. Mochizuki; M. Matsuda Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504 Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504 Journal of Biological Chemistry, 274, 20, 14376-14381 , 274, 20, 14376-14381 Journal of Biological Chemistry, 274, 20, 14376-14381 1999 有 英語 公開
N. Mochizuki; Y. Ohba; E. Kiyokawa; T. Kurata; T. Murakami; T. Ozaki; A. Kitabatake; K. Nagashima; M. Matsuda N. Mochizuki; Y. Ohba; E. Kiyokawa; T. Kurata; T. Murakami; T. Ozaki; A. Kitabatake; K. Nagashima; M. Matsuda Activation of the ERK/MAPK pathway by an isoform of rap1 GAP associated with Gα(i) Activation of the ERK/MAPK pathway by an isoform of rap1 GAP associated with Gα(i) Nature, 400, 6747, 891-894 , 400, 6747, 891-894 Nature, 400, 6747, 891-894 1999 有 英語 公開
H. Katayama; Y. Hashimoto; E. Kiyokawa; M. Nakaya; A. Sakamoto; R. Machinami; T. Kurata; N. Mochizuki; M. Matsuda H. Katayama; Y. Hashimoto; E. Kiyokawa; M. Nakaya; A. Sakamoto; R. Machinami; T. Kurata; N. Mochizuki; M. Matsuda Epidermal growth factor-dependent dissociation of CrkII proto-oncogene product from the epidermal growth factor receptor in human glioma cells Epidermal growth factor-dependent dissociation of CrkII proto-oncogene product from the epidermal growth factor receptor in human glioma cells Japanese Journal of Cancer Research, 90, 10, 1096-1103 , 90, 10, 1096-1103 Japanese Journal of Cancer Research, 90, 10, 1096-1103 1999 有 英語 公開
S. Ota; S. Kizaka-Kondoh; Y. Hashimoto; H. Nishihara; K. Nagashima; T. Kurata; H. Okayama; M. Matsuda S. Ota; S. Kizaka-Kondoh; Y. Hashimoto; H. Nishihara; K. Nagashima; T. Kurata; H. Okayama; M. Matsuda Constitutive association of EGF receptor with the CrkII-23 mutant that inhibits transformation of NRK cells by EGF and TGF-β Constitutive association of EGF receptor with the CrkII-23 mutant that inhibits transformation of NRK cells by EGF and TGF-β Cellular Signalling, 10, 4, 283-290 , 10, 4, 283-290 Cellular Signalling, 10, 4, 283-290 1998 有 英語 公開
S. Okada; M. Matsuda; M. Anafi; T. Pawson; J.E. Pessin S. Okada; M. Matsuda; M. Anafi; T. Pawson; J.E. Pessin Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes EMBO Journal, 17, 9, 2554-2565 , 17, 9, 2554-2565 EMBO Journal, 17, 9, 2554-2565 1998 有 英語 公開
E. Kiyokawa; Y. Hashimoto; S. Kobayashi; H. Sugimura; T. Kurata; M. Matsuda E. Kiyokawa; Y. Hashimoto; S. Kobayashi; H. Sugimura; T. Kurata; M. Matsuda Activation of Rac1 by a Crk SH3-binding protein, DOCK180 Activation of Rac1 by a Crk SH3-binding protein, DOCK180 Genes and Development, 12, 21, 3331-3336 , 12, 21, 3331-3336 Genes and Development, 12, 21, 3331-3336 1998 有 英語 公開
Y. Hashimoto; H. Katayama; E. Kiyokawa; S. Ota; T. Kurata; N. Gotoh; N. Otsuka; M. Shibata; M. Matsuda Y. Hashimoto; H. Katayama; E. Kiyokawa; S. Ota; T. Kurata; N. Gotoh; N. Otsuka; M. Shibata; M. Matsuda Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor Journal of Biological Chemistry, 273, 27, 17186-17191 , 273, 27, 17186-17191 Journal of Biological Chemistry, 273, 27, 17186-17191 1998 有 英語 公開
E. Kiyokawa; Y. Hashimoto; T. Kurata; H. Sugimura; M. Matsuda E. Kiyokawa; Y. Hashimoto; T. Kurata; H. Sugimura; M. Matsuda Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex Journal of Biological Chemistry, 273, 38, 24479-24484 , 273, 38, 24479-24484 Journal of Biological Chemistry, 273, 38, 24479-24484 1998 有 英語 公開
H. Kawasaki; G.M. Springett; N. Mochizuki; S. Toki; M. Nakaya; M. Matsuda; D.E. Housman; A.M. Graybiel H. Kawasaki; G.M. Springett; N. Mochizuki; S. Toki; M. Nakaya; M. Matsuda; D.E. Housman; A.M. Graybiel A family of cAMP-binding proteins that directly activate Rap1 A family of cAMP-binding proteins that directly activate Rap1 Science, 282, 5397, 2275-2279 , 282, 5397, 2275-2279 Science, 282, 5397, 2275-2279 1998 有 英語 公開
K. Tokunaga; E. Kiyokawa; M. Nakaya; N. Otsuka; A. Kojima; T. Kurata; M. Matsuda K. Tokunaga; E. Kiyokawa; M. Nakaya; N. Otsuka; A. Kojima; T. Kurata; M. Matsuda Inhibition of human immunodeficiency virus type 1 virion entry by dominant-negative Hck Inhibition of human immunodeficiency virus type 1 virion entry by dominant-negative Hck Journal of Virology, 72, 7, 6257-6259 , 72, 7, 6257-6259 Journal of Virology, 72, 7, 6257-6259 1998 有 英語 公開
T. Ichiba; Y. Kuraishi; O. Sakai; S. Nagata; J. Groffen; T. Kurata; S. Hattori; M. Matsuda T. Ichiba; Y. Kuraishi; O. Sakai; S. Nagata; J. Groffen; T. Kurata; S. Hattori; M. Matsuda Enhancement of guanine-nucleotide exchange activity of C3G for Rap1 by the expression of Crk, CrkL, and Grb2 Enhancement of guanine-nucleotide exchange activity of C3G for Rap1 by the expression of Crk, CrkL, and Grb2 Journal of Biological Chemistry, 272, 35, 22215-22220 , 272, 35, 22215-22220 Journal of Biological Chemistry, 272, 35, 22215-22220 1997 有 英語 公開
T. Gotoh; Y. Niino; M. Tokuda; O. Hatase; S. Nakamura; M. Matsuda; S. Hattori T. Gotoh; Y. Niino; M. Tokuda; O. Hatase; S. Nakamura; M. Matsuda; S. Hattori Activation of R-Ras by Ras-guanine nucleotide-releasing factor Activation of R-Ras by Ras-guanine nucleotide-releasing factor Journal of Biological Chemistry, 272, 30, 18602-18607 , 272, 30, 18602-18607 Journal of Biological Chemistry, 272, 30, 18602-18607 1997 有 英語 公開
E. Kiyokawa; N. Mochizuki; T. Kurata; M. Matsuda E. Kiyokawa; N. Mochizuki; T. Kurata; M. Matsuda Role of Crk oncogene product in physiologic signaling Role of Crk oncogene product in physiologic signaling Critical Reviews in Oncogenesis, 8, 4, 329-342 , 8, 4, 329-342 Critical Reviews in Oncogenesis, 8, 4, 329-342 1997 有 英語 公開
R.J. Ingham; D.L. Krebs; S.M. Barbazuk; C.W. Turck; H. Hirai; M. Matsuda; M.R. Gold R.J. Ingham; D.L. Krebs; S.M. Barbazuk; C.W. Turck; H. Hirai; M. Matsuda; M.R. Gold B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins Journal of Biological Chemistry, 271, 50, 32306-32314 , 271, 50, 32306-32314 Journal of Biological Chemistry, 271, 50, 32306-32314 1996 有 英語 公開
M. Matsuda; T. Kurata M. Matsuda; T. Kurata Emerging components of the Crk oncogene product: The first identified adaptor protein Emerging components of the Crk oncogene product: The first identified adaptor protein Cellular Signalling, 8, 5, 335-340 , 8, 5, 335-340 Cellular Signalling, 8, 5, 335-340 1996 有 英語 公開
S. Takai; H. Hasegawa; E. Kiyokawa; K. Yamada; T. Kurata; M. Matsuda S. Takai; H. Hasegawa; E. Kiyokawa; K. Yamada; T. Kurata; M. Matsuda Chromosomal mapping of the gene encoding DOCK180, a major Crk-binding protein, to 10q26.13-q26.3 by Fluorescence in situ hybridization Chromosomal mapping of the gene encoding DOCK180, a major Crk-binding protein, to 10q26.13-q26.3 by Fluorescence in situ hybridization Genomics, 35, 2, 403-404 , 35, 2, 403-404 Genomics, 35, 2, 403-404 1996 有 英語 公開
M. Matsuda; S. Ota; R. Tanimura; H. Nakamura; K. Matuoka; T. Takenawa; K. Nagashima; T. Kurata M. Matsuda; S. Ota; R. Tanimura; H. Nakamura; K. Matuoka; T. Takenawa; K. Nagashima; T. Kurata Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins Journal of Biological Chemistry, 271, 24, 14468-14472 , 271, 24, 14468-14472 Journal of Biological Chemistry, 271, 24, 14468-14472 1996 有 英語 公開
H. Hasegawa; E. Kiyokawa; S. Tanaka; K. Nagashima; N. Gotoh; M. Shibuya; T. Kurata; M. Matsuda H. Hasegawa; E. Kiyokawa; S. Tanaka; K. Nagashima; N. Gotoh; M. Shibuya; T. Kurata; M. Matsuda DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane Molecular and Cellular Biology, 16, 4, 1770-1776 , 16, 4, 1770-1776 Molecular and Cellular Biology, 16, 4, 1770-1776 1996 有 英語 公開
T. Gotoh; S. Hattori; S. Nakamura; H. Kitayama; M. Noda; Y. Takai; K. Kaibuchi; H. Matsui; O. Hatase; H. Takahashi; T. Kurata; M. Matsuda T. Gotoh; S. Hattori; S. Nakamura; H. Kitayama; M. Noda; Y. Takai; K. Kaibuchi; H. Matsui; O. Hatase; H. Takahashi; T. Kurata; M. Matsuda Identification of Rap 1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G Identification of Rap 1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G Molecular and Cellular Biology, 15, 12, 6746-6753 , 15, 12, 6746-6753 Molecular and Cellular Biology, 15, 12, 6746-6753 1995 有 英語 公開
S. Takai; M. Tanaka; H. Sugimura; K. Yamada; Y. Naito; I. Kino; M. Matsuda S. Takai; M. Tanaka; H. Sugimura; K. Yamada; Y. Naito; I. Kino; M. Matsuda Mapping of the human C3G gene coding a guanine nucleotide releasing protein for Ras family to 9q34.3 by fluorescence in situ hybridization Mapping of the human C3G gene coding a guanine nucleotide releasing protein for Ras family to 9q34.3 by fluorescence in situ hybridization Human Genetics, 94, 5, 549-550 , 94, 5, 549-550 Human Genetics, 94, 5, 549-550 1994 有 英語 公開
M. Matsuda; Y. Hashimoto; K. Muroya; H. Hasegawa; T. Kurata; S. Tanaka; S. Nakamura; S. Hattori M. Matsuda; Y. Hashimoto; K. Muroya; H. Hasegawa; T. Kurata; S. Tanaka; S. Nakamura; S. Hattori CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells Molecular and Cellular Biology, 14, 8, 5495-5500 , 14, 8, 5495-5500 Molecular and Cellular Biology, 14, 8, 5495-5500 1994 有 英語 公開
T. Shinohara; M. Matsuda; S.H. Cheng; J. Marshall; M. Fujita; K. Nagashima T. Shinohara; M. Matsuda; S.H. Cheng; J. Marshall; M. Fujita; K. Nagashima BK virus infection of the human urinary tract BK virus infection of the human urinary tract Journal of Medical Virology, 41, 4, 301-305 , 41, 4, 301-305 Journal of Medical Virology, 41, 4, 301-305 1993 有 英語 公開
S. Tanaka; S. Hattori; T. Kurata; K. Nagashima; Y. Fukui; S. Nakamura; M. Matsuda S. Tanaka; S. Hattori; T. Kurata; K. Nagashima; Y. Fukui; S. Nakamura; M. Matsuda Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells Molecular and Cellular Biology, 13, 7, 4409-4415 , 13, 7, 4409-4415 Molecular and Cellular Biology, 13, 7, 4409-4415 1993 有 英語 公開
K. Tobe; K. Matuoka; H. Tamemoto; K. Ueki; Y. Kaburagi; S. Asai; T. Noguchi; M. Matsuda; S. Tanaka; S. Hattori; Y. Fukui; Y. Akanuma; Y. Yazaki; T. Takenawa; T. Kadowaki K. Tobe; K. Matuoka; H. Tamemoto; K. Ueki; Y. Kaburagi; S. Asai; T. Noguchi; M. Matsuda; S. Tanaka; S. Hattori; Y. Fukui; Y. Akanuma; Y. Yazaki; T. Takenawa; T. Kadowaki Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2 Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2 Journal of Biological Chemistry, 268, 15, 11167-11171 , 268, 15, 11167-11171 Journal of Biological Chemistry, 268, 15, 11167-11171 1993 有 英語 公開
S. Tanaka; M. Matsuda; S. Nagata; T. Kurata; K. Nagashima; Y. Shizawa; Y. Fukui S. Tanaka; M. Matsuda; S. Nagata; T. Kurata; K. Nagashima; Y. Shizawa; Y. Fukui Structure of 85 kDa subunit of human phosphatidylinositol 3-kinase analyzed by using monoclonal antibodies Structure of 85 kDa subunit of human phosphatidylinositol 3-kinase analyzed by using monoclonal antibodies Japanese Journal of Cancer Research, 84, 3, 279-289 , 84, 3, 279-289 Japanese Journal of Cancer Research, 84, 3, 279-289 1993 有 英語 公開
M. Matsuda; S. Nagata; S. Tanaka; K. Nagashima; T. Kurata M. Matsuda; S. Nagata; S. Tanaka; K. Nagashima; T. Kurata Structural requirement of CRK SH2 region for binding to phosphotyrosine-containing proteins: Evidence from reactivity to monoclonal antibodies Structural requirement of CRK SH2 region for binding to phosphotyrosine-containing proteins: Evidence from reactivity to monoclonal antibodies Journal of Biological Chemistry, 268, 6, 4441-4446 , 268, 6, 4441-4446 Journal of Biological Chemistry, 268, 6, 4441-4446 1993 有 英語 公開
M. Matsuda; S. Tanaka; S. Nagata; A. Kojima; T. Kurata; M. Shibuya M. Matsuda; S. Tanaka; S. Nagata; A. Kojima; T. Kurata; M. Shibuya Two species of human CRK cDNA encode proteins with distinct biological activities Two species of human CRK cDNA encode proteins with distinct biological activities Molecular and Cellular Biology, 12, 8, 3482-3489 , 12, 8, 3482-3489 Molecular and Cellular Biology, 12, 8, 3482-3489 1992/08 有 英語 公開
M. Matsuda; K. Yasui; K. Nagashima; W. Mori M. Matsuda; K. Yasui; K. Nagashima; W. Mori Origin of the medulloblastoma experimentally induced by human polyomavirus JC Origin of the medulloblastoma experimentally induced by human polyomavirus JC Journal of the National Cancer Institute, 79, 3, 585-591 , 79, 3, 585-591 Journal of the National Cancer Institute, 79, 3, 585-591 1987 有 英語 公開
M. Matsuda; K. Nagashima M. Matsuda; K. Nagashima Cytoplasmic tubular inclusion in ganglioneuroma Cytoplasmic tubular inclusion in ganglioneuroma Acta Neuropathologica, 64, 1, 81-84 , 64, 1, 81-84 Acta Neuropathologica, 64, 1, 81-84 1984 有 英語 公開

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タイトル言語:
Misc
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Y. Kamioka; K. Sumiyama; R. Mizuno; M. Matsuda Y. Kamioka; K. Sumiyama; R. Mizuno; M. Matsuda Live imaging of transgenic mice expressing FRET biosensors Live imaging of transgenic mice expressing FRET biosensors Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 125-128 , 125-128 Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 125-128 2013 有 英語 公開
K. Aoki; M. Yamada; K. Kunida; S. Yasuda; M. Matsuda K. Aoki; M. Yamada; K. Kunida; S. Yasuda; M. Matsuda Processive phosphorylation of ERK MAP kinase in mammalian cells Processive phosphorylation of ERK MAP kinase in mammalian cells Proceedings of the National Academy of Sciences of the United States of America, 108, 31, 12675-12680 , 108, 31, 12675-12680 Proceedings of the National Academy of Sciences of the United States of America, 108, 31, 12675-12680 2011/08/02 有 英語 公開
M. Nakaya; M. Kitano; M. Matsuda; S. Nagata M. Nakaya; M. Kitano; M. Matsuda; S. Nagata Spatiotemporal activation of Rac1 for engulfment of apoptotic cells Spatiotemporal activation of Rac1 for engulfment of apoptotic cells Proceedings of the National Academy of Sciences of the United States of America, 105, 27, 9198-9203 , 105, 27, 9198-9203 Proceedings of the National Academy of Sciences of the United States of America, 105, 27, 9198-9203 2008/07/08 有 英語 公開
F. Dolfi; M. Garcia-Guzman; M. Ojaniemi; H. Nakamura; M. Matsuda; K. Vuori F. Dolfi; M. Garcia-Guzman; M. Ojaniemi; H. Nakamura; M. Matsuda; K. Vuori The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway Proceedings of the National Academy of Sciences of the United States of America, 95, 26, 15394-15399 , 95, 26, 15394-15399 Proceedings of the National Academy of Sciences of the United States of America, 95, 26, 15394-15399 1998 有 英語 公開
H. Kawasaki; G.M. Springett; S. Toki; J.J. Canales; P. Harlan; J.P. Blumenstiel; E.J. Chen; I.A. Bany; N. Mochizuki; A. Ashbacher; M. Matsuda; D.E. Housman; A.M. Graybiel H. Kawasaki; G.M. Springett; S. Toki; J.J. Canales; P. Harlan; J.P. Blumenstiel; E.J. Chen; I.A. Bany; N. Mochizuki; A. Ashbacher; M. Matsuda; D.E. Housman; A.M. Graybiel A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia Proceedings of the National Academy of Sciences of the United States of America, 95, 22, 13278-13283 , 95, 22, 13278-13283 Proceedings of the National Academy of Sciences of the United States of America, 95, 22, 13278-13283 1998 有 英語 公開
S. Kizaka-Kondoh; M. Matsuda; H. Okayama S. Kizaka-Kondoh; M. Matsuda; H. Okayama CrkII signals from epidermal growth factor receptor to Ras CrkII signals from epidermal growth factor receptor to Ras Proceedings of the National Academy of Sciences of the United States of America, 93, 22, 12177-12182 , 93, 22, 12177-12182 Proceedings of the National Academy of Sciences of the United States of America, 93, 22, 12177-12182 1996 有 英語 公開
H. Takahashi; M. Matsuda; A. Kojima; T. Sata; T. Andoh; T. Kurata; K. Nagashima; W.W. Hall H. Takahashi; M. Matsuda; A. Kojima; T. Sata; T. Andoh; T. Kurata; K. Nagashima; W.W. Hall Human immunodeficiency virus type 1 reverse transcriptase: Enhancement of activity by interaction with cellular topoisomerase I Human immunodeficiency virus type 1 reverse transcriptase: Enhancement of activity by interaction with cellular topoisomerase I Proceedings of the National Academy of Sciences of the United States of America, 92, 12, 5694-5698 , 92, 12, 5694-5698 Proceedings of the National Academy of Sciences of the United States of America, 92, 12, 5694-5698 1995 有 英語 公開
S. Tanaka; T. Morishita; Y. Hashimoto; S. Hattori; S. Nakamura; M. Shibuya; K. Matuoka; T. Takenawa; T. Kurata; K. Nagashima; M. Matsuda S. Tanaka; T. Morishita; Y. Hashimoto; S. Hattori; S. Nakamura; M. Shibuya; K. Matuoka; T. Takenawa; T. Kurata; K. Nagashima; M. Matsuda C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins Proceedings of the National Academy of Sciences of the United States of America, 91, 8, 3443-3447 , 91, 8, 3443-3447 Proceedings of the National Academy of Sciences of the United States of America, 91, 8, 3443-3447 1994 有 英語 公開
タイトル言語:
特許
発明者 発明者(日本語) 発明者(英語) 発明の名称 発明の名称(日本語) 発明の名称(英語) 審査の段階 番号 年月 公開
CRKタンパクに対するモノクローナル抗体と、この抗体を産生するハイブリドーマ株 CRKタンパクに対するモノクローナル抗体と、この抗体を産生するハイブリドーマ株 公開
C3G蛋白遺伝子のcDNA C3G蛋白遺伝子のcDNA 公開
ヒトアデノシン5’-ホスホ硫酸キナーゼのDNA断片およびDNAプローブ ヒトアデノシン5’-ホスホ硫酸キナーゼのDNA断片およびDNAプローブ 公開
DOCK180蛋白遺伝子のcDNA DOCK180蛋白遺伝子のcDNA 公開
三量体型Ｇ蛋白質の活性モニター分子 三量体型Ｇ蛋白質の活性モニター分子 公開
タイトル言語:
学術賞等
賞の名称(日本語) 賞の名称(英語) 授与組織名(日本語) 授与組織名(英語) 年月
第6回佐川特別研究助成賞 SGH Foundation 公益法人SGH財団 SGH Foundation 2008/11/15
持田記念学術賞 Mochida Academic Award 公益財団法人　持田記念医学薬学振興財団 Mochida Memorial Foundation for Medical and Pharmaceutical Research 2011/10/28
中谷賞大賞 Nakatani Prize 中谷医工計測技術振興財団 Nakatani Foundation 2018/02/16
自ら企画した研究集会
集会名 学会名 年月
International Symposium on Multi-dimensional Fluorescent Imaging of Cellular Functions and Molecular Activities 2015/01/26
第68回日本細胞生物学会大会 日本細胞生物学会 2016/06/15
外部資金：競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
特定領域研究 代表 細胞がん化過程の時空間制御機構の解析 2005〜2009
基盤研究（Ａ） 代表 細胞小胞輸送に関わる低分子量ＧＴＰ結合蛋白の蛍光イメージングによる時空間的解析 2007〜2010
新学術領域研究 代表 細胞内情報伝達系の多次元ＦＲＥＴイメージング 2010〜2014
新学術領域研究 代表 細胞機能と分子活性の多次元蛍光生体イメージング 2010〜2014
新学術領域研究（研究領域提案型） 代表 細胞機能と分子活性の多次元蛍光生体イメージング 2010〜2014
新学術領域研究（研究領域提案型） 代表 細胞内情報伝達系の多次元ＦＲＥＴイメージング 2010〜2014
特別研究員奨励費 代表 生きたマウスでｐ５３からＡＴＭへのフィードバックループの動態を解析する 2012〜2014
特別研究員奨励費 代表 生きたマウスでｐ５３からＡＴＭへのフィードバックループの動態を解析する （平成26年度分） 2014/04/01〜2015/03/31
新学術領域研究（研究領域提案型） 代表 細胞内情報伝達系の多次元ＦＲＥＴイメージング （平成26年度分） 2014/04/01〜2015/03/31
新学術領域研究（研究領域提案型） 代表 細胞機能と分子活性の多次元蛍光生体イメージング （平成26年度分） 2014/04/01〜2015/03/31
基盤研究（Ａ） 代表 FRETマウスを用いた生体イメージング （平成27年度分） 2015/04/01〜2016/03/31
新学術領域研究（研究領域提案型） 代表 細胞機能と分子活性の多次元蛍光生体イメージング （平成27年度分） 2015/04/01〜2016/03/31
新学術領域研究（研究領域提案型） 代表 細胞間コミュニケーションのライブイメージング （平成27年度分） 2015/04/01〜2016/03/31
新学術領域研究（研究領域提案型） 代表 細胞内情報伝達系の多次元ＦＲＥＴイメージング （平成27年度分） 2015/04/01〜2016/03/31
新学術領域研究（研究領域提案型） 代表 細胞間コミュニケーションのライブイメージング （平成28年度分） 2016/04/01〜2017/03/31
基盤研究(A) 代表 FRETマウスを用いた生体イメージング （平成28年度分） 2016/04/01〜2017/03/31
基盤研究(A) 代表 FRETマウスを用いた生体イメージング （平成29年度分） 2017/04/01〜2018/03/31
基盤研究(A) 代表 FRETマウスを用いた生体イメージング （平成29年度分） 2017/04/01〜2018/03/31
新学術領域研究（研究領域提案型） 代表 細胞間コミュニケーションのライブイメージング （平成29年度分） 2017/04/01〜2018/03/31
新学術領域研究（研究領域提案型） 代表 細胞間コミュニケーションのライブイメージング （平成29年度分） 2017/04/01〜2018/03/31
基盤研究(A) 代表 FRETマウスを用いた生体イメージング （平成30年度分） 2018/04/01〜2019/03/31
基盤研究(A) 代表 FRETマウスを用いた生体イメージング （平成30年度分） 2018/04/01〜2019/03/31
新学術領域研究（研究領域提案型） 代表 細胞間コミュニケーションのライブイメージング （平成30年度分） 2018/04/01〜2019/03/31
新学術領域研究（研究領域提案型） 代表 細胞間コミュニケーションのライブイメージング （平成30年度分） 2018/04/01〜2019/03/31
基盤研究（A） 代表 細胞増殖因子情報伝達系の活性波による細胞集団移動制御機構（平成31年度分） 2019/04/01〜2020/03/31
新学術領域研究（研究領域提案型） 代表 細胞間コミュニケーションのライブイメージング （平成31年度分） 2019/04/01〜2020/03/31

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外部資金：競争的資金・科学研究費補助金以外
制度名 代表者名 研究課題(日本語) 研究課題(英語) 期間
文部科学省 創薬等ライフサイエンス研究支援基盤事業 松田　道行 多次元定量イメージングに基づく数理モデルを用いた動的生命システムの革新的研究体系の開発・教育拠点 2012〜2016
文部科学省 創薬等ライフサイエンス研究支援基盤事業 松田　道行 多次元定量イメージングに基づく数理モデルを用いた動的生命システムの革新的研究体系の開発・教育拠点 （平成26年度分） 2014/04/01〜2015/03/31
文部科学省 医療研究開発推進事業費補助金 松田　道行 多次元定量イメージングに基づく数理モデルを用いた動的生命システムの革新的研究体系の開発・教育拠点 （平成27年度分） 2015/04/01〜2016/03/31
医療研究開発推進事業費補助金 松田　道行 多次元定量イメージングに基づく数理モデルを用いた動的生命システムの革新的研究体系の開発・教育拠点 （平成28年度分） 2016/04/01〜2017/03/31
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
病理学総論 General Pathology 〜
病理学　II 前期不定 医学研究科 2011/04〜2012/03
病理学 前期不定 医学研究科 2011/04〜2012/03
発生・細胞生物学（演習） 通年不定 医学研究科 2011/04〜2012/03
発生・細胞生物学（実習） 通年不定 医学研究科 2011/04〜2012/03
生命科学概論Ａ Perspectives on Life Science A 前期 全学共通科目 2011/04〜2012/03
生命科学概論Ａ Perspectives on Life Science A 前期 全学共通科目 2012/04〜2013/03
病理学 General Pathology 通年不定 医学研究科 2012/04〜2013/03
病理学　II General Pathology II 前期不定 医学研究科 2012/04〜2013/03
発生・細胞生物学（実習） Cell and Developmental Biology(Practice) 通年 医学研究科 2012/04〜2013/03
発生・細胞生物学（演習） Cell and Developmental Biology(Seminar) 通年 医学研究科 2012/04〜2013/03
B4 病理学総論 General Pathology 前期 医学部 2013/04〜2014/03
病理学　II General Pathology II 前期不定 医学研究科 2013/04〜2014/03
病理学 General Pathology 前期不定 医学研究科 2013/04〜2014/03
発生・細胞生物学・システム生物学（演習） 通年不定 医学研究科 2013/04〜2014/03
発生・細胞生物学・システム生物学（実習） 通年不定 医学研究科 2013/04〜2014/03
シグナル伝達学特論 Advanced Course in Studies on Signal Transduction 後期集中 生命科学研究科 2013/04〜2014/03
生命科学概論Ｉ Study of Life Science I 前期 全学共通科目 2013/04〜2014/03
B4 病理学総論 General Pathology 前期 医学部 2014/04〜2015/03
病理学　II General Pathology II 前期不定 医学研究科 2014/04〜2015/03
病理学 General Pathology 前期不定 医学研究科 2014/04〜2015/03
発生・細胞生物学・システム生物学（演習） Cell, Developmental and Systems Biology (Seminar) 通年不定 医学研究科 2014/04〜2015/03
発生・細胞生物学・システム生物学（実習） Cell, Developmental and Systems Biology (Practice) 通年不定 医学研究科 2014/04〜2015/03
シグナル伝達学特論 Advanced Course in Studies on Signal Transduction 後期集中 生命科学研究科 2014/04〜2015/03
特別実験及び演習第1 Experimental Course and Seminar l 通年 生命科学研究科 2014/04〜2015/03
特別実験及び演習第2 Experimental Course and Seminar 2 通年 生命科学研究科 2014/04〜2015/03
特別実験及び演習第2 Experimental Course and Seminar 2 後期前期 生命科学研究科 2014/04〜2015/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 通年 生命科学研究科 2014/04〜2015/03
分子細胞生物学 Molecular and Cellular Biology 後期 総合生存学館 2014/04〜2015/03
生命科学概論Ｉ Study of Life Science I 前期 全学共通科目 2014/04〜2015/03
B4 病理学総論 General Pathology 前期 医学部 2015/04〜2016/03
シグナル伝達学特論 Advanced Course in Studies on Signal Transduction 前期集中 生命科学研究科 2015/04〜2016/03
分子細胞生物学 Molecular and Cellular Biology 後期 総合生存学館 2015/04〜2016/03
特別実験及び演習 Experimental Course and Seminar 前期不定 生命科学研究科 2015/04〜2016/03
特別実験及び演習 Experimental Course and Seminar 後期不定 生命科学研究科 2015/04〜2016/03
生命科学概論Ｉ Study of Life Science I 前期 全学共通科目 2015/04〜2016/03
病理学 General Pathology 前期不定 医学研究科 2015/04〜2016/03
病理学　II General Pathology II 前期不定 医学研究科 2015/04〜2016/03
発生・細胞生物学・システム生物学（実習） Cell, Developmental and Systems Biology (Practice) 通年不定 医学研究科 2015/04〜2016/03
発生・細胞生物学・システム生物学（演習） Cell, Developmental and Systems Biology (Seminar) 通年不定 医学研究科 2015/04〜2016/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 前期不定 生命科学研究科 2015/04〜2016/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 後期不定 生命科学研究科 2015/04〜2016/03
B4 病理学総論 General Pathology 前期 医学部 2016/04〜2017/03
シグナル伝達学特論 Advanced Course in Studies on Signal Transduction 前期集中 生命科学研究科 2016/04〜2017/03
分子細胞生物学 Molecular and Cellular Biology 後期 総合生存学館 2016/04〜2017/03
特別実験及び演習 Experimental Course and Seminar 前期不定 生命科学研究科 2016/04〜2017/03
特別実験及び演習 Experimental Course and Seminar 後期不定 生命科学研究科 2016/04〜2017/03
生物・生命科学入門 Introduction to Biology and Life Science 前期 全学共通科目 2016/04〜2017/03
病理学 General Pathology 前期不定 医学研究科 2016/04〜2017/03
病理学　II General Pathology II 前期不定 医学研究科 2016/04〜2017/03
発生・細胞生物学・システム生物学（実習） Cell, Developmental and Systems Biology (Practice) 通年不定 医学研究科 2016/04〜2017/03
発生・細胞生物学・システム生物学（演習） Cell, Developmental and Systems Biology (Seminar) 通年不定 医学研究科 2016/04〜2017/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 前期不定 生命科学研究科 2016/04〜2017/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 後期不定 生命科学研究科 2016/04〜2017/03
B4 病理学総論 General Pathology 前期 医学部 2017/04〜2018/03
シグナル伝達学特論 Advanced Course in Studies on Signal Transduction 後期集中 生命科学研究科 2017/04〜2018/03
分子細胞生物学 Molecular and Cellular Biology 後期 総合生存学館 2017/04〜2018/03
特別実験及び演習 Experimental Course and Seminar 前期不定 生命科学研究科 2017/04〜2018/03
特別実験及び演習 Experimental Course and Seminar 後期不定 生命科学研究科 2017/04〜2018/03
病理学 General Pathology 前期不定 医学研究科 2017/04〜2018/03
病理学　II General Pathology II 前期不定 医学研究科 2017/04〜2018/03
発生・細胞生物学・システム生物学（実習） Cell, Developmental and Systems Biology (Practice) 通年不定 医学研究科 2017/04〜2018/03
発生・細胞生物学・システム生物学（演習） Cell, Developmental and Systems Biology (Seminar) 通年不定 医学研究科 2017/04〜2018/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 前期不定 生命科学研究科 2017/04〜2018/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 後期不定 生命科学研究科 2017/04〜2018/03
B4 病理学総論 General Pathology 前期 医学部 2018/04〜2019/03
B9 病理学総論 General Pathology 前期 医学部 2018/04〜2019/03
シグナル伝達学特論 Advanced Course in Studies on Signal Transduction 前期集中 生命科学研究科 2018/04〜2019/03
特別実験及び演習Ａ Experimental Course and Seminar A 前期不定 生命科学研究科 2018/04〜2019/03
特別実験及び演習Ａ Experimental Course and Seminar A 後期不定 生命科学研究科 2018/04〜2019/03
特別実験及び演習Ｂ Experimental Course and Seminar B 前期不定 生命科学研究科 2018/04〜2019/03
特別実験及び演習Ｂ Experimental Course and Seminar B 後期不定 生命科学研究科 2018/04〜2019/03
特別実験及び演習Ｃ Experimental Course and Seminar C 前期不定 生命科学研究科 2018/04〜2019/03
特別実験及び演習Ｃ Experimental Course and Seminar C 後期不定 生命科学研究科 2018/04〜2019/03
特別実験及び演習Ｄ Experimental Course and Seminar D 前期不定 生命科学研究科 2018/04〜2019/03
特別実験及び演習Ｄ Experimental Course and Seminar D 後期不定 生命科学研究科 2018/04〜2019/03
特別実験及び演習 Experimental Course and Seminar 前期不定 生命科学研究科 2018/04〜2019/03
特別実験及び演習 Experimental Course and Seminar 後期不定 生命科学研究科 2018/04〜2019/03
生物・生命科学入門 Introduction to Biology and Life Science 前期 全学共通科目 2018/04〜2019/03
病理学 General Pathology 前期不定 医学研究科 2018/04〜2019/03
病理学　II General Pathology II 前期不定 医学研究科 2018/04〜2019/03
発生・細胞生物学・システム生物学（実習） Cell, Developmental and Systems Biology (Practice) 通年不定 医学研究科 2018/04〜2019/03
発生・細胞生物学・システム生物学（演習） Cell, Developmental and Systems Biology (Seminar) 通年不定 医学研究科 2018/04〜2019/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 前期不定 生命科学研究科 2018/04〜2019/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 後期不定 生命科学研究科 2018/04〜2019/03
B4 病理学総論 General Pathology 前期 医学部 2019/04〜2020/03
B9 病理学総論 General Pathology 前期 医学部 2019/04〜2020/03
シグナル伝達学特論 Advanced Course in Studies on Signal Transduction 後期集中 生命科学研究科 2019/04〜2020/03
特別実験及び演習Ａ Experimental Course and Seminar A 前期不定 生命科学研究科 2019/04〜2020/03
特別実験及び演習Ａ Experimental Course and Seminar A 後期不定 生命科学研究科 2019/04〜2020/03
特別実験及び演習Ｂ Experimental Course and Seminar B 前期不定 生命科学研究科 2019/04〜2020/03
特別実験及び演習Ｂ Experimental Course and Seminar B 後期不定 生命科学研究科 2019/04〜2020/03
特別実験及び演習Ｃ Experimental Course and Seminar C 前期不定 生命科学研究科 2019/04〜2020/03
特別実験及び演習Ｃ Experimental Course and Seminar C 後期不定 生命科学研究科 2019/04〜2020/03
特別実験及び演習Ｄ Experimental Course and Seminar D 前期不定 生命科学研究科 2019/04〜2020/03
特別実験及び演習Ｄ Experimental Course and Seminar D 後期不定 生命科学研究科 2019/04〜2020/03
特別実験及び演習 Experimental Course and Seminar 前期不定 生命科学研究科 2019/04〜2020/03
特別実験及び演習 Experimental Course and Seminar 後期不定 生命科学研究科 2019/04〜2020/03
病理学 General Pathology 前期不定 医学研究科 2019/04〜2020/03
病理学　II General Pathology II 前期不定 医学研究科 2019/04〜2020/03
発生・細胞生物学・システム生物学（修士実習） Cell, Developmental and Systems Biologys (Practice for Master Program) 通年不定 医学研究科 2019/04〜2020/03
発生・細胞生物学・システム生物学（修士演習） Cell, Developmental and Systems Biology (Seminar for Master Program) 通年不定 医学研究科 2019/04〜2020/03
発生・細胞生物学・システム生物学（実習） Cell, Developmental and Systems Biology (Practice) 通年不定 医学研究科 2019/04〜2020/03
発生・細胞生物学・システム生物学（演習） Cell, Developmental and Systems Biology (Seminar) 通年不定 医学研究科 2019/04〜2020/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 前期不定 生命科学研究科 2019/04〜2020/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 後期不定 生命科学研究科 2019/04〜2020/03

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学外非常勤講師
講義名(日本語) 講義名(英語) 開講期 学校名 学部/研究科名 期間
広島大学 医学部 2015/04/02〜2016/03/31
熊本大学 2019/04/05〜2020/03/31
全学運営（役職等）
役職名 期間
京都大学組換えDNA実験安全委員会 委員 2009/04/01〜2013/03/31
京都大学ヒトゲノム・遺伝子解析研究管理委員会 委員 2011/09/11〜2015/09/10
学生生活委員会 委員 2013/04/01〜2015/03/31
奨学金返還免除候補者選考委員会 委員 2013/04/01〜2015/03/31
学生表彰選考委員会 委員 2015/01/01〜2015/03/31
ヒトゲノム・遺伝子解析研究管理委員会 委員 2015/09/11〜2015/12/31
国際高等教育院 企画評価専門委員会 生物学部会 委員 2013/07/10〜2015/04/30
生命動態研究センター長 2018/04/01〜2020/03/31
国際教育委員会国際学生交流委員会アムジェン・スカラーズ・プログラム小委員会 委員 2017/12/21〜2019/03/31
設備整備・共用促進委員会 委員 2018/10/01〜2020/09/30
施設整備委員会 委員 2018/10/01〜2020/09/30
施設整備委員会　吉田キャンパス整備専門委員会 委員 2018/10/01〜2020/09/30

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部局運営（役職等）
役職名 期間
制度・財政委員会　委員 2009/04/01〜2014/03/31
高次生命科学副専攻長 2009/04/01〜2010/03/31
高次生命科学専攻長 2010/04/01〜2011/03/31
高次生命科学専攻長 2013/04/01〜2014/03/31
中期目標・中期計画検討委員会 2009/07/01〜2017/03/31
動物実験施設管理委員会 2013/04/01〜2015/03/31
動物実験施設運営委員会 2013/04/01〜2014/03/31
医学広報委員会 2012/10/01〜2013/09/30
医学研究科・医学部教授選考方針検討委員会(基礎系検討委員会) 2012/11/01〜2014/10/31
医学研究科運営委員会 〜2014/09/30
大学評価部局委員会 2011/10/01〜2013/09/30
管理体制委員会 2012/10/01〜2014/09/30
医学研究科バイオ・フロンティア・プラットフォーム運営委員会 2012/02/01〜
間接経費使途検討委員会 2013/10/01〜2016/09/30
奨学金免除返還候補者審査委員会委員 2014/10/01〜2015/09/30
医学研究科基礎系副専攻長 2015/06/11〜2016/09/30
利益相反予備審査委員会 2016/04/01〜
医学研究科寄附講座運営委員会（創薬医学） 2016/04/01〜2020/03/31
医学研究科等防犯カメラ設置運用委員会 2014/08/01〜2017/11/30
医学研究支援センター運営委員会 2011/11/10〜
医学部資料館運営委員会 2014/04/01〜
医学研究科人事活性化委員会 2015/09/24〜
高次生命科学副専攻長 2012/04/01〜2013/03/31
大学院医学研究科・医学部及び医学部附属病院医の倫理委員会小委員会　委員 2011/04/01〜2013/03/31
ウイルス・再生医科学研究科諮問会議　構成員 2018/04/01〜2019/03/31
医学研究科・医学部将来計画検討委員会委員 2017/04/01〜2019/03/31
医学研究科・人権委員会 2018/10/01〜2019/09/30
医学研究科・IFOM-KU　国際共同ラボ　運営委員会 2018/10/01〜

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その他活動：国・地方公共団体での活動
委員会名(日本語) 委員会名(英語) 役職名 公共団体の名称 期間
日本学術会議 Science Council of Japan 会員 内閣府 2017/10/01〜2021/09/30
その他活動：民間企業・NPO等の兼業
相手先名 兼業の内容 期間
医学書院 「生体の科学」編集委員 2012/04/01〜

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