服部 雅一

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氏名(漢字/フリガナ/アルファベット表記)
服部 雅一/ハットリ マサカズ/Hattori, Masakazu
所属部署・職名(部局/所属/講座等/職名)
医学研究科/免疫老化学講座(産学共同)/特定教授
学部兼担
部局 所属 講座等 職名
医学部
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
獣医学修士 北海道大学
博士(獣医学) 北海道大学
使用言語
言語名(japanese) 言語名(english) コード
英語 English eng
日本語 Japanese jpn
researchmap URL
https://researchmap.jp/read0051943
研究テーマ
(日本語)
免疫老化誘導機構の解明とその制御
(英語)
Study on Immunosenescence and its regulation
研究概要
(日本語)
加齢に伴う免疫系、特にT細胞の機能低下・変容は癌や感染症リスクの増大のみならず慢性炎症性病態や自己免疫疾患の発症につながっていると考えられてきたが、その詳細なメカニズムは長い間不明であった。我々の研究室では加齢に伴い増加する炎症性状を有するT細胞集団を同定し、老化関連T細胞(senescence-associated T:SA-T細胞) と名付けた。現在、この細胞集団による自己免疫疾患やII型糖尿病などの慢性炎症性病態との関連性に調べるとともに、その制御機構を明らかにし、これらの疾患に対する新しい治療薬の創出をめざし研究を行っている。
(英語)
Immunosenescence is age-associated changes in the immunological functions, including diminished acquired immunity against infection, pro-inflammatory traits, and increased risk of autoimmunity. The proportions of memory-phenotype T cells in the peripheral T-cell population steadily increase with age, but the relationship between this change and immunosenescent phenotypes remains elusive. Recently, we identified a minor memory-phenotype CD4+ T-cell subpopulation that constitutively expressed PD-1 and CD153 as a bona fide age-dependent T-cell population; we termed these cells senescence-associated T (SA-T) cells. SA-T cells exhibit characteristic features of cellular senescence, with defective T-cell receptor-mediated proliferation and T-cell cytokine production. However, upon T-cell receptor stimulation, SA-T cells secrete abundant atypical pro-inflammatory cytokines such as osteopontin and chemokines, reminiscent of the SA-secretory phenotype. In addition to aging, SA-T cells accumulate and cause persistent inflammation in tissues following a wide range of insults including immune complex deposition, metabolic stresses, vascular damages, and tumors. In this review, we summarize the recent understanding of immunosenescence with particular focus on SA-T cells and their role in various age-related disorders.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
免疫老化, 自己免疫疾患 Immunosenescence、autoimmune diseases
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Fukushima Y, Minato N, Hattori M Fukushima Y, Minato N, Hattori M Fukushima Y, Minato N, Hattori M The impact of senescence-associated T cells on immunosenescence and age-related disorders. The impact of senescence-associated T cells on immunosenescence and age-related disorders. The impact of senescence-associated T cells on immunosenescence and age-related disorders. Inflammation and Regeneration, 24, 38 Inflammation and Regeneration, 24, 38 Inflammation and Regeneration, 24, 38 2018/12 英語 研究論文(学術雑誌) 公開
Koyu Ito, Akira Nakajima, Yuji Fukushima, Keiichiro Suzuki, Keiko Sakamoto, Yoko Hamazaki, Kouetsu Ogasawara, Nagahiro Minato, Masakazu Hattori Koyu Ito, Akira Nakajima, Yuji Fukushima, Keiichiro Suzuki, Keiko Sakamoto, Yoko Hamazaki, Kouetsu Ogasawara, Nagahiro Minato, Masakazu Hattori Koyu Ito, Akira Nakajima, Yuji Fukushima, Keiichiro Suzuki, Keiko Sakamoto, Yoko Hamazaki, Kouetsu Ogasawara, Nagahiro Minato, Masakazu Hattori The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine. The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine. The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine. PloS one, 12, 3, e0173629 PloS one, 12, 3, e0173629 PloS one, 12, 3, e0173629 2017 英語 公開
Keiko Sakamoto, Yuji Fukushima, Koyu Ito, Michiyuki Matsuda, Shigekazu Nagata, Nagahiro Minato, Masakazu Hattori Keiko Sakamoto, Yuji Fukushima, Koyu Ito, Michiyuki Matsuda, Shigekazu Nagata, Nagahiro Minato, Masakazu Hattori Keiko Sakamoto, Yuji Fukushima, Koyu Ito, Michiyuki Matsuda, Shigekazu Nagata, Nagahiro Minato, Masakazu Hattori Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice. Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice. Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice. Journal of immunology (Baltimore, Md. : 1950), 197, 6, 2177-86 Journal of immunology (Baltimore, Md. : 1950), 197, 6, 2177-86 Journal of immunology (Baltimore, Md. : 1950), 197, 6, 2177-86 2016/09/15 英語 研究論文(学術雑誌) 公開
Suhail Tahir, Yuji Fukushima, Keiko Sakamoto, Kyosuke Sato, Harumi Fujita, Joe Inoue, Toshimitsu Uede, Yoko Hamazaki, Masakazu Hattori, Nagahiro Minato Suhail Tahir, Yuji Fukushima, Keiko Sakamoto, Kyosuke Sato, Harumi Fujita, Joe Inoue, Toshimitsu Uede, Yoko Hamazaki, Masakazu Hattori, Nagahiro Minato Suhail Tahir, Yuji Fukushima, Keiko Sakamoto, Kyosuke Sato, Harumi Fujita, Joe Inoue, Toshimitsu Uede, Yoko Hamazaki, Masakazu Hattori, Nagahiro Minato A CD153(+)CD4(+) T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production A CD153(+)CD4(+) T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production A CD153(+)CD4(+) T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production JOURNAL OF IMMUNOLOGY, 194, 12, 5725-5735 JOURNAL OF IMMUNOLOGY, 194, 12, 5725-5735 JOURNAL OF IMMUNOLOGY, 194, 12, 5725-5735 2015/06 英語 研究論文(学術雑誌) 公開
Masakazu Hattori, Nagahiro Minato Masakazu Hattori, Nagahiro Minato Masakazu Hattori, Nagahiro Minato T-cell senescence and autoimmune diseases T-cell senescence and autoimmune diseases T-cell senescence and autoimmune diseases Japanese Journal of Allergology, 64, 2, 110-118 Japanese Journal of Allergology, 64, 2, 110-118 Japanese Journal of Allergology, 64, 2, 110-118 2015 日本語 研究論文(学術雑誌) 公開
Minekatsu Akimoto, Akira Takeda, Osamu Matsushita, Joe Inoue, Keiko Sakamoto, Masakazu Hattori, Natsuko Kounoike, Eiju Uchinuma Minekatsu Akimoto, Akira Takeda, Osamu Matsushita, Joe Inoue, Keiko Sakamoto, Masakazu Hattori, Natsuko Kounoike, Eiju Uchinuma Minekatsu Akimoto, Akira Takeda, Osamu Matsushita, Joe Inoue, Keiko Sakamoto, Masakazu Hattori, Natsuko Kounoike, Eiju Uchinuma Effects of CB-VEGF-A Injection in Rat Flap Models for Improved Survival Effects of CB-VEGF-A Injection in Rat Flap Models for Improved Survival Effects of CB-VEGF-A Injection in Rat Flap Models for Improved Survival PLASTIC AND RECONSTRUCTIVE SURGERY, 131, 4, 717-725 PLASTIC AND RECONSTRUCTIVE SURGERY, 131, 4, 717-725 PLASTIC AND RECONSTRUCTIVE SURGERY, 131, 4, 717-725 2013/04 英語 研究論文(学術雑誌) 公開
Kyoko Hayashida, Kiichi Kajino, Masakazu Hattori, Maura Wallace, Ivan Morrison, Mark I. Greene, Chihiro Sugimoto Kyoko Hayashida, Kiichi Kajino, Masakazu Hattori, Maura Wallace, Ivan Morrison, Mark I. Greene, Chihiro Sugimoto Kyoko Hayashida, Kiichi Kajino, Masakazu Hattori, Maura Wallace, Ivan Morrison, Mark I. Greene, Chihiro Sugimoto MDM2 regulates a novel form of incomplete neoplastic transformation of Theileria parva infected lymphocytes MDM2 regulates a novel form of incomplete neoplastic transformation of Theileria parva infected lymphocytes MDM2 regulates a novel form of incomplete neoplastic transformation of Theileria parva infected lymphocytes Experimental and Molecular Pathology, 94, 1, 228-238 Experimental and Molecular Pathology, 94, 1, 228-238 Experimental and Molecular Pathology, 94, 1, 228-238 2013/02 英語 研究論文(学術雑誌) 公開
Yosuke Shimizu, Yoko Hamazaki, Masakazu Hattori, Keiko Doi, Naoki Terada, Takashi Kobayashi, Yoshinobu Toda, Toshinari Yamasaki, Takahiro Inoue, Yoichiro Kajita, Atsushi Maeno, Tomomi Kamba, Yoshiki Mikami, Toshiyuki Kamoto, Tomomi Yamada, Toru Kanno, Kiyotsugu Yoshikawa, Osamu Ogawa, Nagahiro Minato, Eijiro Nakamura Yosuke Shimizu, Yoko Hamazaki, Masakazu Hattori, Keiko Doi, Naoki Terada, Takashi Kobayashi, Yoshinobu Toda, Toshinari Yamasaki, Takahiro Inoue, Yoichiro Kajita, Atsushi Maeno, Tomomi Kamba, Yoshiki Mikami, Toshiyuki Kamoto, Tomomi Yamada, Toru Kanno, Kiyotsugu Yoshikawa, Osamu Ogawa, Nagahiro Minato, Eijiro Nakamura Yosuke Shimizu, Yoko Hamazaki, Masakazu Hattori, Keiko Doi, Naoki Terada, Takashi Kobayashi, Yoshinobu Toda, Toshinari Yamasaki, Takahiro Inoue, Yoichiro Kajita, Atsushi Maeno, Tomomi Kamba, Yoshiki Mikami, Toshiyuki Kamoto, Tomomi Yamada, Toru Kanno, Kiyotsugu Yoshikawa, Osamu Ogawa, Nagahiro Minato, Eijiro Nakamura SPA-1 controls the invasion and metastasis of human prostate cancer SPA-1 controls the invasion and metastasis of human prostate cancer SPA-1 controls the invasion and metastasis of human prostate cancer CANCER SCIENCE, 102, 4, 828-836 CANCER SCIENCE, 102, 4, 828-836 CANCER SCIENCE, 102, 4, 828-836 2011/04 英語 研究論文(学術雑誌) 公開
K. Hayashida, M. Hattori, R. Nakao, Y. Tanaka, J.-Y. Kim, N. Inoue, V. Nene, C. Sugimoto K. Hayashida, M. Hattori, R. Nakao, Y. Tanaka, J.-Y. Kim, N. Inoue, V. Nene, C. Sugimoto Kyoko Hayashida, Masakazu Hattori, Ryo Nakao, Yoshimasa Tanaka, Jung-Yeon Kim, Noboru Inoue, Vishvanath Nene, Chihiro Sugimoto A schizont-derived protein, TpSCOP, is involved in the activation of NF-κB in Theileria parva-infected lymphocytes A schizont-derived protein, TpSCOP, is involved in the activation of NF-κB in Theileria parva-infected lymphocytes A schizont-derived protein, TpSCOP, is involved in the activation of NF-kappa B in Theileria parva-infected lymphocytes Molecular and Biochemical Parasitology, 174, 1, 8-17 Molecular and Biochemical Parasitology, 174, 1, 8-17 MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 174, 1, 8-17 2010/11 英語 研究論文(学術雑誌) 公開
Yoshinori Katayama, Miho Sekai, Masakazu Hattori, Ichiro Miyoshi, Yoko Hamazaki, Nagahiro Minato Yoshinori Katayama, Miho Sekai, Masakazu Hattori, Ichiro Miyoshi, Yoko Hamazaki, Nagahiro Minato Yoshinori Katayama, Miho Sekai, Masakazu Hattori, Ichiro Miyoshi, Yoko Hamazaki, Nagahiro Minato Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells BLOOD, 114, 9, 1768-1775 BLOOD, 114, 9, 1768-1775 BLOOD, 114, 9, 1768-1775 2009/08 英語 研究論文(学術雑誌) 公開
Yoshiaki Nakajima, Masaki Moriyama, Masakazu Hattori, Nagahiro Minato, Shigetada Nakanishi Yoshiaki Nakajima, Masaki Moriyama, Masakazu Hattori, Nagahiro Minato, Shigetada Nakanishi Yoshiaki Nakajima, Masaki Moriyama, Masakazu Hattori, Nagahiro Minato, Shigetada Nakanishi Isolation of ON Bipolar Cell Genes via hrGFP-coupled Cell Enrichment Using the mGluR6 Promoter Isolation of ON Bipolar Cell Genes via hrGFP-coupled Cell Enrichment Using the mGluR6 Promoter Isolation of ON Bipolar Cell Genes via hrGFP-coupled Cell Enrichment Using the mGluR6 Promoter JOURNAL OF BIOCHEMISTRY, 145, 6, 811-818 JOURNAL OF BIOCHEMISTRY, 145, 6, 811-818 JOURNAL OF BIOCHEMISTRY, 145, 6, 811-818 2009/06 英語 研究論文(学術雑誌) 公開
Satoru Hara, Chiaki Nakaseko, Sho Yamasaki, Masakazu Hattori, Johannes L. Bos, Yasushi Saito, Nagahiro Minato, Takashi Saito Satoru Hara, Chiaki Nakaseko, Sho Yamasaki, Masakazu Hattori, Johannes L. Bos, Yasushi Saito, Nagahiro Minato, Takashi Saito Satoru Hara, Chiaki Nakaseko, Sho Yamasaki, Masakazu Hattori, Johannes L. Bos, Yasushi Saito, Nagahiro Minato, Takashi Saito Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal HEMATOLOGY, 14, 3, 150-158 HEMATOLOGY, 14, 3, 150-158 HEMATOLOGY, 14, 3, 150-158 2009/06 英語 研究論文(学術雑誌) 公開
Nagahiro Minato, Masakazu Hattori Nagahiro Minato, Masakazu Hattori Nagahiro Minato, Masakazu Hattori Spa-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis Spa-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis Spa-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis CANCER SCIENCE, 100, 1, 17-23 CANCER SCIENCE, 100, 1, 17-23 CANCER SCIENCE, 100, 1, 17-23 2009/01 英語 公開
Kohei Kometani, Masaki Moriyama, Yasuhiro Nakashima, Yoshinori Katayama, Shu-Fang Wang, Sho Yamasaki, Takashi Saito, Masakazu Hattori, Nagahiro Minato Kohei Kometani, Masaki Moriyama, Yasuhiro Nakashima, Yoshinori Katayama, Shu-Fang Wang, Sho Yamasaki, Takashi Saito, Masakazu Hattori, Nagahiro Minato Kohei Kometani, Masaki Moriyama, Yasuhiro Nakashima, Yoshinori Katayama, Shu-Fang Wang, Sho Yamasaki, Takashi Saito, Masakazu Hattori, Nagahiro Minato Essential role of Rap signal in pre-TCR-mediated beta-selection checkpoint in alpha beta T-cell development Essential role of Rap signal in pre-TCR-mediated beta-selection checkpoint in alpha beta T-cell development Essential role of Rap signal in pre-TCR-mediated beta-selection checkpoint in alpha beta T-cell development BLOOD, 112, 12, 4565-4573 BLOOD, 112, 12, 4565-4573 BLOOD, 112, 12, 4565-4573 2008/12 英語 研究論文(学術雑誌) 公開
Shu-Fang Wang, Misayo Aoki, Yasuhiro Nakashima, Yoriko Shinozuka, Hiroki Tanaka, Masafumi Taniwaki, Masakazu Hattori, Nagahiro Minatol Shu-Fang Wang, Misayo Aoki, Yasuhiro Nakashima, Yoriko Shinozuka, Hiroki Tanaka, Masafumi Taniwaki, Masakazu Hattori, Nagahiro Minatol Shu-Fang Wang, Misayo Aoki, Yasuhiro Nakashima, Yoriko Shinozuka, Hiroki Tanaka, Masafumi Taniwaki, Masakazu Hattori, Nagahiro Minatol Development of Notch-dependent T-cell leukemia by deregulated Rap1 signaling Development of Notch-dependent T-cell leukemia by deregulated Rap1 signaling Development of Notch-dependent T-cell leukemia by deregulated Rap1 signaling BLOOD, 111, 5, 2878-2886 BLOOD, 111, 5, 2878-2886 BLOOD, 111, 5, 2878-2886 2008/03 英語 研究論文(学術雑誌) 公開
Takanori Kitamura, Kohei Kometani, Hiroki Hashida, Akihiro Matsunaga, Hiroyuki Miyoshi, Hisahiro Hosogi, Masahiro Aoki, Masanobu Oshima, Masakazu Hattori, Arimichi Takabayashi, Nagahiro Minato, Makoto M. Taketo Takanori Kitamura, Kohei Kometani, Hiroki Hashida, Akihiro Matsunaga, Hiroyuki Miyoshi, Hisahiro Hosogi, Masahiro Aoki, Masanobu Oshima, Masakazu Hattori, Arimichi Takabayashi, Nagahiro Minato, Makoto M. Taketo Takanori Kitamura, Kohei Kometani, Hiroki Hashida, Akihiro Matsunaga, Hiroyuki Miyoshi, Hisahiro Hosogi, Masahiro Aoki, Masanobu Oshima, Masakazu Hattori, Arimichi Takabayashi, Nagahiro Minato, Makoto M. Taketo SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion NATURE GENETICS, 39, 4, 467-475 NATURE GENETICS, 39, 4, 467-475 NATURE GENETICS, 39, 4, 467-475 2007/04 英語 研究論文(学術雑誌) 公開
Nagahiro Minato, Kohei Kometani, Masakazu Hattori Nagahiro Minato, Kohei Kometani, Masakazu Hattori Nagahiro Minato, Kohei Kometani, Masakazu Hattori Regulation of immune responses and hematopoiesis by the Rap1 signal Regulation of immune responses and hematopoiesis by the Rap1 signal Regulation of immune responses and hematopoiesis by the Rap1 signal ADVANCES IN IMMUNOLOGY, VOL 93, 93, 229-264 ADVANCES IN IMMUNOLOGY, VOL 93, 93, 229-264 ADVANCES IN IMMUNOLOGY, VOL 93, 93, 229-264 2007 英語 公開
Kohei Kometani, Misayo Aoki, Shin Kawamata, Yoriko Shinozuka, Takumi Era, Masafumi Taniwaki, Masakazu Hattori, Nagahiro Minato Kohei Kometani, Misayo Aoki, Shin Kawamata, Yoriko Shinozuka, Takumi Era, Masafumi Taniwaki, Masakazu Hattori, Nagahiro Minato Kohei Kometani, Misayo Aoki, Shin Kawamata, Yoriko Shinozuka, Takumi Era, Masafumi Taniwaki, Masakazu Hattori, Nagahiro Minato Role of SPA-1 in phenotypes of chronic myelogenous leukemia induced by BCR-ABL-expressing hematopoietic progenitors in a mouse model Role of SPA-1 in phenotypes of chronic myelogenous leukemia induced by BCR-ABL-expressing hematopoietic progenitors in a mouse model Role of SPA-1 in phenotypes of chronic myelogenous leukemia induced by BCR-ABL-expressing hematopoietic progenitors in a mouse model CANCER RESEARCH, 66, 20, 9967-9976 CANCER RESEARCH, 66, 20, 9967-9976 CANCER RESEARCH, 66, 20, 9967-9976 2006/10 英語 研究論文(学術雑誌) 公開
A. Jin, T. Kurosu, K. Tsuji, D. Mizuchi, A. Arai, H. Fujita, M. Hattori, N. Minato, O. Miura A. Jin, T. Kurosu, K. Tsuji, D. Mizuchi, A. Arai, H. Fujita, M. Hattori, N. Minato, O. Miura A. Jin, T. Kurosu, K. Tsuji, D. Mizuchi, A. Arai, H. Fujita, M. Hattori, N. Minato, O. Miura BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion ONCOGENE, 25, 31, 4332-4340 ONCOGENE, 25, 31, 4332-4340 ONCOGENE, 25, 31, 4332-4340 2006/07 英語 研究論文(学術雑誌) 公開
D Ishida, L Su, A Tamura, Y Katayama, Y Kawai, SF Wang, M Taniwaki, Y Hamazaki, M Hattori, N Minato D Ishida, L Su, A Tamura, Y Katayama, Y Kawai, SF Wang, M Taniwaki, Y Hamazaki, M Hattori, N Minato D Ishida, L Su, A Tamura, Y Katayama, Y Kawai, SF Wang, M Taniwaki, Y Hamazaki, M Hattori, N Minato Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells IMMUNITY, 24, 4, 417-427 IMMUNITY, 24, 4, 417-427 IMMUNITY, 24, 4, 417-427 2006/04 英語 研究論文(学術雑誌) 公開
K Masuda, H Kubagawa, T Ikawa, CC Chen, K Kakugawa, M Hattori, R Kageyama, MD Cooper, N Minato, Y Katsura, H Kawamoto K Masuda, H Kubagawa, T Ikawa, CC Chen, K Kakugawa, M Hattori, R Kageyama, MD Cooper, N Minato, Y Katsura, H Kawamoto K Masuda, H Kubagawa, T Ikawa, CC Chen, K Kakugawa, M Hattori, R Kageyama, MD Cooper, N Minato, Y Katsura, H Kawamoto Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors EMBO JOURNAL, 24, 23, 4052-4060 EMBO JOURNAL, 24, 23, 4052-4060 EMBO JOURNAL, 24, 23, 4052-4060 2005/12 英語 研究論文(学術雑誌) 公開
K Murata, M Hattori, N Hirai, Y Shinozuka, H Hirata, R Kageyama, T Sakai, N Minato K Murata, M Hattori, N Hirai, Y Shinozuka, H Hirata, R Kageyama, T Sakai, N Minato K Murata, M Hattori, N Hirai, Y Shinozuka, H Hirata, R Kageyama, T Sakai, N Minato Hes1 directly controls cell proliferation through the transcriptional repression of p27(Kip1) Hes1 directly controls cell proliferation through the transcriptional repression of p27(Kip1) Hes1 directly controls cell proliferation through the transcriptional repression of p27(Kip1) MOLECULAR AND CELLULAR BIOLOGY, 25, 10, 4262-4271 MOLECULAR AND CELLULAR BIOLOGY, 25, 10, 4262-4271 MOLECULAR AND CELLULAR BIOLOGY, 25, 10, 4262-4271 2005/05 英語 研究論文(学術雑誌) 公開
A Farina, M Hattori, J Qin, Y Nakatani, N Minato, K Ozato A Farina, M Hattori, J Qin, Y Nakatani, N Minato, K Ozato A Farina, M Hattori, J Qin, Y Nakatani, N Minato, K Ozato Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization MOLECULAR AND CELLULAR BIOLOGY, 24, 20, 9059-9069 MOLECULAR AND CELLULAR BIOLOGY, 24, 20, 9059-9069 MOLECULAR AND CELLULAR BIOLOGY, 24, 20, 9059-9069 2004/10 英語 研究論文(学術雑誌) 公開
K Kometani, D Ishida, M Hattori, N Minato K Kometani, D Ishida, M Hattori, N Minato K Kometani, D Ishida, M Hattori, N Minato Rap1 and SPA-1 in hematologic malignancy Rap1 and SPA-1 in hematologic malignancy Rap1 and SPA-1 in hematologic malignancy TRENDS IN MOLECULAR MEDICINE, 10, 8, 401-408 TRENDS IN MOLECULAR MEDICINE, 10, 8, 401-408 TRENDS IN MOLECULAR MEDICINE, 10, 8, 401-408 2004/08 英語 公開
Y Noda, S Horikawa, T Furukawa, K Hirai, Y Katayama, T Asai, M Kuwahara, K Katagiri, T Kinashi, M Hattori, N Minato, S Sasaki Y Noda, S Horikawa, T Furukawa, K Hirai, Y Katayama, T Asai, M Kuwahara, K Katagiri, T Kinashi, M Hattori, N Minato, S Sasaki Y Noda, S Horikawa, T Furukawa, K Hirai, Y Katayama, T Asai, M Kuwahara, K Katagiri, T Kinashi, M Hattori, N Minato, S Sasaki Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1 Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1 Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1 FEBS LETTERS, 568, 1-3, 139-145 FEBS LETTERS, 568, 1-3, 139-145 FEBS LETTERS, 568, 1-3, 139-145 2004/06 英語 研究論文(学術雑誌) 公開
M Harazaki, Y Kawai, L Su, Y Hamazaki, T Nakahata, N Minato, M Hattori M Harazaki, Y Kawai, L Su, Y Hamazaki, T Nakahata, N Minato, M Hattori M Harazaki, Y Kawai, L Su, Y Hamazaki, T Nakahata, N Minato, M Hattori Specific recruitment of SPA-1 to the immunological synapse: involvement of actin-bundling protein actinin Specific recruitment of SPA-1 to the immunological synapse: involvement of actin-bundling protein actinin Specific recruitment of SPA-1 to the immunological synapse: involvement of actin-bundling protein actinin IMMUNOLOGY LETTERS, 92, 3, 221-226 IMMUNOLOGY LETTERS, 92, 3, 221-226 IMMUNOLOGY LETTERS, 92, 3, 221-226 2004/04 英語 研究論文(学術雑誌) 公開
M Hattori, N Minato M Hattori, N Minato M Hattori, N Minato Rap1 GTPase: Functions, regulation, and malignancy Rap1 GTPase: Functions, regulation, and malignancy Rap1 GTPase: Functions, regulation, and malignancy JOURNAL OF BIOCHEMISTRY, 134, 4, 479-484 JOURNAL OF BIOCHEMISTRY, 134, 4, 479-484 JOURNAL OF BIOCHEMISTRY, 134, 4, 479-484 2003/10 英語 公開
K. Kakugawa, M. Hattori, N. Beauchemin, N. Minato K. Kakugawa, M. Hattori, N. Beauchemin, N. Minato K Kakugawa, M Hattori, N Beauchemin, N Minato Activation of CEA-CAM-1-mediated cell adhesion via CD98: Involvement of PKCδ Activation of CEA-CAM-1-mediated cell adhesion via CD98: Involvement of PKCδ Activation of CEA-CAM-1-mediated cell adhesion via CD98: involvement of PKC delta FEBS Letters, 552, 2-3, 184-188 FEBS Letters, 552, 2-3, 184-188 FEBS LETTERS, 552, 2-3, 184-188 2003/09 英語 研究論文(学術雑誌) 公開
D Ishida, K Kometani, HL Yang, K Kakugawa, K Masuda, K Iwai, M Suzuki, S Itohara, T Nakahata, H Hiai, H Kawamoto, M Hattori, N Minato D Ishida, K Kometani, HL Yang, K Kakugawa, K Masuda, K Iwai, M Suzuki, S Itohara, T Nakahata, H Hiai, H Kawamoto, M Hattori, N Minato D Ishida, K Kometani, HL Yang, K Kakugawa, K Masuda, K Iwai, M Suzuki, S Itohara, T Nakahata, H Hiai, H Kawamoto, M Hattori, N Minato Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice CANCER CELL, 4, 1, 55-65 CANCER CELL, 4, 1, 55-65 CANCER CELL, 4, 1, 55-65 2003/07 英語 研究論文(学術雑誌) 公開
L Su, M Hattori, M Moriyama, N Murata, M Harazaki, K Kaibuchi, N Minato L Su, M Hattori, M Moriyama, N Murata, M Harazaki, K Kaibuchi, N Minato L Su, M Hattori, M Moriyama, N Murata, M Harazaki, K Kaibuchi, N Minato AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1 AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1 AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1 JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 17, 15232-15238 JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 17, 15232-15238 JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 17, 15232-15238 2003/04 英語 研究論文(学術雑誌) 公開
K Katagiri, M Hattori, N Minato, T Kinashi K Katagiri, M Hattori, N Minato, T Kinashi K Katagiri, M Hattori, N Minato, T Kinashi Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses MOLECULAR AND CELLULAR BIOLOGY, 22, 4, 1001-1015 MOLECULAR AND CELLULAR BIOLOGY, 22, 4, 1001-1015 MOLECULAR AND CELLULAR BIOLOGY, 22, 4, 1001-1015 2002/02 英語 研究論文(学術雑誌) 公開
K Suga, K Katagiri, T Kinashi, M Harazaki, T Iizuka, M Hattori, N Minato K Suga, K Katagiri, T Kinashi, M Harazaki, T Iizuka, M Hattori, N Minato K Suga, K Katagiri, T Kinashi, M Harazaki, T Iizuka, M Hattori, N Minato CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation of Rap1 CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation of Rap1 CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation of Rap1 FEBS LETTERS, 489, 2-3, 249-253 FEBS LETTERS, 489, 2-3, 249-253 FEBS LETTERS, 489, 2-3, 249-253 2001/02 英語 研究論文(学術雑誌) 公開
N Ohno, A Izawa, M Hattori, R Kageyama, T Sudo N Ohno, A Izawa, M Hattori, R Kageyama, T Sudo N Ohno, A Izawa, M Hattori, R Kageyama, T Sudo dlk inhibits stem cell factor-induced colony formation of murine hematopoietic progenitors: Hes-1-independent effect dlk inhibits stem cell factor-induced colony formation of murine hematopoietic progenitors: Hes-1-independent effect dlk inhibits stem cell factor-induced colony formation of murine hematopoietic progenitors: Hes-1-independent effect STEM CELLS, 19, 1, 71-79 STEM CELLS, 19, 1, 71-79 STEM CELLS, 19, 1, 71-79 2001 英語 研究論文(学術雑誌) 公開
K Katagiri, M Hattori, N Minato, S Irie, K Takatsu, T Kinashi K Katagiri, M Hattori, N Minato, S Irie, K Takatsu, T Kinashi K Katagiri, M Hattori, N Minato, S Irie, K Takatsu, T Kinashi Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase MOLECULAR AND CELLULAR BIOLOGY, 20, 6, 1956-1969 MOLECULAR AND CELLULAR BIOLOGY, 20, 6, 1956-1969 MOLECULAR AND CELLULAR BIOLOGY, 20, 6, 1956-1969 2000/03 英語 研究論文(学術雑誌) 公開
N Tsukamoto, M Hattori, HL Yang, JL Bos, N Minato N Tsukamoto, M Hattori, HL Yang, JL Bos, N Minato N Tsukamoto, M Hattori, HL Yang, JL Bos, N Minato Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion JOURNAL OF BIOLOGICAL CHEMISTRY, 274, 26, 18463-18469 JOURNAL OF BIOLOGICAL CHEMISTRY, 274, 26, 18463-18469 JOURNAL OF BIOLOGICAL CHEMISTRY, 274, 26, 18463-18469 1999/06 英語 研究論文(学術雑誌) 公開
K Tomita, M Hattori, E Nakamura, S Nakanishi, N Minato, R Kageyama K Tomita, M Hattori, E Nakamura, S Nakanishi, N Minato, R Kageyama K Tomita, M Hattori, E Nakamura, S Nakanishi, N Minato, R Kageyama The bHLH gene Hes1 is essential for expansion of early T cell precursors The bHLH gene Hes1 is essential for expansion of early T cell precursors The bHLH gene Hes1 is essential for expansion of early T cell precursors GENES & DEVELOPMENT, 13, 9, 1203-1210 GENES & DEVELOPMENT, 13, 9, 1203-1210 GENES & DEVELOPMENT, 13, 9, 1203-1210 1999/05 英語 研究論文(学術雑誌) 公開
T Morimura, KO Cho, Y Kudo, Y Hiramoto, K Ohashi, M Hattori, C Sugimoto, M Onuma T Morimura, KO Cho, Y Kudo, Y Hiramoto, K Ohashi, M Hattori, C Sugimoto, M Onuma T Morimura, KO Cho, Y Kudo, Y Hiramoto, K Ohashi, M Hattori, C Sugimoto, M Onuma Anti-viral and anti-tumor effects induced by an attenuated Marek's disease virus in CD4-or CD8-deficient chickens Anti-viral and anti-tumor effects induced by an attenuated Marek's disease virus in CD4-or CD8-deficient chickens Anti-viral and anti-tumor effects induced by an attenuated Marek's disease virus in CD4-or CD8-deficient chickens ARCHIVES OF VIROLOGY, 144, 9, 1809-1818 ARCHIVES OF VIROLOGY, 144, 9, 1809-1818 ARCHIVES OF VIROLOGY, 144, 9, 1809-1818 1999 英語 研究論文(学術雑誌) 公開
H Kurachi, Y Wada, N Tsukamoto, M Maeda, H Kubota, M Hattori, K Iwai, N Minato H Kurachi, Y Wada, N Tsukamoto, M Maeda, H Kubota, M Hattori, K Iwai, N Minato H Kurachi, Y Wada, N Tsukamoto, M Maeda, H Kubota, M Hattori, K Iwai, N Minato Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2 - Segregate expression profiles from a rap1GAP gene product Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2 - Segregate expression profiles from a rap1GAP gene product Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2 - Segregate expression profiles from a rap1GAP gene product JOURNAL OF BIOLOGICAL CHEMISTRY, 272, 44, 28081-28088 JOURNAL OF BIOLOGICAL CHEMISTRY, 272, 44, 28081-28088 JOURNAL OF BIOLOGICAL CHEMISTRY, 272, 44, 28081-28088 1997/10 英語 研究論文(学術雑誌) 公開
K Okada, Y Tanaka, K Murakami, S Chiba, T Morimura, M Hattori, M Goryo, M Onuma K Okada, Y Tanaka, K Murakami, S Chiba, T Morimura, M Hattori, M Goryo, M Onuma K Okada, Y Tanaka, K Murakami, S Chiba, T Morimura, M Hattori, M Goryo, M Onuma Phenotype analysis of lymphoid cells in Marek's disease of CD4(+) or CD8(+) T-cell-deficient chickens: occurrence of double negative T-cell tumour Phenotype analysis of lymphoid cells in Marek's disease of CD4(+) or CD8(+) T-cell-deficient chickens: occurrence of double negative T-cell tumour Phenotype analysis of lymphoid cells in Marek's disease of CD4(+) or CD8(+) T-cell-deficient chickens: occurrence of double negative T-cell tumour AVIAN PATHOLOGY, 26, 3, 525-534 AVIAN PATHOLOGY, 26, 3, 525-534 AVIAN PATHOLOGY, 26, 3, 525-534 1997/09 英語 研究論文(学術雑誌) 公開
Toshifumi Morimura Toshifumi Morimura Toshifumi Morimura Apoptosis in peripheral CD4+T cells and thymocytes by Marek's disease virus-infection Apoptosis in peripheral CD4+T cells and thymocytes by Marek's disease virus-infection Apoptosis in peripheral CD4+T cells and thymocytes by Marek's disease virus-infection Leukemia, 11, 3, 206-208 Leukemia, 11, 3, 206-208 Leukemia, 11, 3, 206-208 1997 英語 研究論文(学術雑誌) 公開
Y Wada, H Kubota, M Maeda, M Taniwaki, M Hattori, S Imamura, K Iwai, N Minato Y Wada, H Kubota, M Maeda, M Taniwaki, M Hattori, S Imamura, K Iwai, N Minato Y Wada, H Kubota, M Maeda, M Taniwaki, M Hattori, S Imamura, K Iwai, N Minato Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human GENOMICS, 39, 1, 66-73 GENOMICS, 39, 1, 66-73 GENOMICS, 39, 1, 66-73 1997/01 英語 研究論文(学術雑誌) 公開
T Morimura, K Ohashi, Y Kon, M Hattori, C Sugimoto, M Onuma T Morimura, K Ohashi, Y Kon, M Hattori, C Sugimoto, M Onuma T Morimura, K Ohashi, Y Kon, M Hattori, C Sugimoto, M Onuma Apoptosis and CD8-down-regulation in the thymus of chickens infected with Marek's disease virus - Brief report Apoptosis and CD8-down-regulation in the thymus of chickens infected with Marek's disease virus - Brief report Apoptosis and CD8-down-regulation in the thymus of chickens infected with Marek's disease virus - Brief report ARCHIVES OF VIROLOGY, 141, 11, 2243-2249 ARCHIVES OF VIROLOGY, 141, 11, 2243-2249 ARCHIVES OF VIROLOGY, 141, 11, 2243-2249 1996 英語 研究論文(学術雑誌) 公開
H Yamamoto, M Hattori, K Ohashi, C Sugimoto, M Onuma H Yamamoto, M Hattori, K Ohashi, C Sugimoto, M Onuma H Yamamoto, M Hattori, K Ohashi, C Sugimoto, M Onuma Characterization of extrathymic T cells of chickens Characterization of extrathymic T cells of chickens Characterization of extrathymic T cells of chickens VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 49, 4, 375-386 VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 49, 4, 375-386 VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 49, 4, 375-386 1996/01 英語 研究論文(学術雑誌) 公開
T MORIMURA, M HATTORI, K OHASHI, C SUGIMOTO, M ONUMA T MORIMURA, M HATTORI, K OHASHI, C SUGIMOTO, M ONUMA T MORIMURA, M HATTORI, K OHASHI, C SUGIMOTO, M ONUMA IMMUNOMODULATION OF PERIPHERAL T-CELLS IN CHICKENS INFECTED WITH MAREKS-DISEASE VIRUS - INVOLVEMENT IN IMMUNOSUPPRESSION IMMUNOMODULATION OF PERIPHERAL T-CELLS IN CHICKENS INFECTED WITH MAREKS-DISEASE VIRUS - INVOLVEMENT IN IMMUNOSUPPRESSION IMMUNOMODULATION OF PERIPHERAL T-CELLS IN CHICKENS INFECTED WITH MAREKS-DISEASE VIRUS - INVOLVEMENT IN IMMUNOSUPPRESSION JOURNAL OF GENERAL VIROLOGY, 76, 12, 2979-2985 JOURNAL OF GENERAL VIROLOGY, 76, 12, 2979-2985 JOURNAL OF GENERAL VIROLOGY, 76, 12, 2979-2985 1995/12 英語 研究論文(学術雑誌) 公開
H YAMAMOTO, M HATTORI, K OHASHI, C SUGIMOTO, M ONUMA H YAMAMOTO, M HATTORI, K OHASHI, C SUGIMOTO, M ONUMA H YAMAMOTO, M HATTORI, K OHASHI, C SUGIMOTO, M ONUMA KINETIC-ANALYSIS OF T-CELLS AND ANTIBODY-PRODUCTION IN CHICKENS INFECTED WITH MAREKS-DISEASE VIRUS KINETIC-ANALYSIS OF T-CELLS AND ANTIBODY-PRODUCTION IN CHICKENS INFECTED WITH MAREKS-DISEASE VIRUS KINETIC-ANALYSIS OF T-CELLS AND ANTIBODY-PRODUCTION IN CHICKENS INFECTED WITH MAREKS-DISEASE VIRUS JOURNAL OF VETERINARY MEDICAL SCIENCE, 57, 5, 945-946 JOURNAL OF VETERINARY MEDICAL SCIENCE, 57, 5, 945-946 JOURNAL OF VETERINARY MEDICAL SCIENCE, 57, 5, 945-946 1995/10 英語 研究論文(学術雑誌) 公開
T MATSUBA, C SUGIMOTO, M HATTORI, Y SAKO, K FUJISAKI, M ONUMA T MATSUBA, C SUGIMOTO, M HATTORI, Y SAKO, K FUJISAKI, M ONUMA T MATSUBA, C SUGIMOTO, M HATTORI, Y SAKO, K FUJISAKI, M ONUMA EXPRESSION OF A 32-KILODALTON THEILERIA-SERGENTI PIROPLASM SURFACE PROTEIN BY RECOMBINANT BACULOVIRUSES EXPRESSION OF A 32-KILODALTON THEILERIA-SERGENTI PIROPLASM SURFACE PROTEIN BY RECOMBINANT BACULOVIRUSES EXPRESSION OF A 32-KILODALTON THEILERIA-SERGENTI PIROPLASM SURFACE PROTEIN BY RECOMBINANT BACULOVIRUSES INTERNATIONAL JOURNAL FOR PARASITOLOGY, 25, 8, 939-943 INTERNATIONAL JOURNAL FOR PARASITOLOGY, 25, 8, 939-943 INTERNATIONAL JOURNAL FOR PARASITOLOGY, 25, 8, 939-943 1995/08 英語 研究論文(学術雑誌) 公開
M HATTORI, N TSUKAMOTO, MSA NUREKAMAL, B RUBINFELD, K IWAI, H KUBOTA, H MARUTA, N MINATO M HATTORI, N TSUKAMOTO, MSA NUREKAMAL, B RUBINFELD, K IWAI, H KUBOTA, H MARUTA, N MINATO M HATTORI, N TSUKAMOTO, MSA NUREKAMAL, B RUBINFELD, K IWAI, H KUBOTA, H MARUTA, N MINATO MOLECULAR-CLONING OF A NOVEL MITOGEN-INDUCIBLE NUCLEAR-PROTEIN WITH A RAN GTPASE-ACTIVATING DOMAIN THAT AFFECTS CELL-CYCLE PROGRESSION MOLECULAR-CLONING OF A NOVEL MITOGEN-INDUCIBLE NUCLEAR-PROTEIN WITH A RAN GTPASE-ACTIVATING DOMAIN THAT AFFECTS CELL-CYCLE PROGRESSION MOLECULAR-CLONING OF A NOVEL MITOGEN-INDUCIBLE NUCLEAR-PROTEIN WITH A RAN GTPASE-ACTIVATING DOMAIN THAT AFFECTS CELL-CYCLE PROGRESSION MOLECULAR AND CELLULAR BIOLOGY, 15, 1, 552-560 MOLECULAR AND CELLULAR BIOLOGY, 15, 1, 552-560 MOLECULAR AND CELLULAR BIOLOGY, 15, 1, 552-560 1995/01 英語 研究論文(学術雑誌) 公開
H. Kubota, M. Sato, Y. Ogawa, K. Iwai, M. Hattori, T. Yoshida, N. Minato H. Kubota, M. Sato, Y. Ogawa, K. Iwai, M. Hattori, T. Yoshida, N. Minato H KUBOTA, M SATO, Y OGAWA, K IWAI, M HATTORI, T YOSHIDA, N MINATO Involvement of 4F2 antigen expressed on the MHC-negative target cells in the recognition of murine CD3<sup>+</sup>CD4<sup>-</sup>CD8<sup>-</sup> αβ (V(α)4/V(β)2) T cells Involvement of 4F2 antigen expressed on the MHC-negative target cells in the recognition of murine CD3<sup>+</sup>CD4<sup>-</sup>CD8<sup>-</sup> αβ (V(α)4/V(β)2) T cells INVOLVEMENT OF 4F2 ANTIGEN EXPRESSED ON THE MHC-NEGATIVE TARGET-CELLS IN THE RECOGNITION OF MURINE CD3+CD4-CD8- ALPHA-BETA (V(ALPHA)4/V(BETA)2) T-CELLS International Immunology, 6, 9, 1323-1331 International Immunology, 6, 9, 1323-1331 INTERNATIONAL IMMUNOLOGY, 6, 9, 1323-1331 1994/09 英語 研究論文(学術雑誌) 公開
T MATSUBA, H KUBOTA, M TANAKA, M HATTORI, M MURATA, C SUGIMOTO, M ONUMA T MATSUBA, H KUBOTA, M TANAKA, M HATTORI, M MURATA, C SUGIMOTO, M ONUMA T MATSUBA, H KUBOTA, M TANAKA, M HATTORI, M MURATA, C SUGIMOTO, M ONUMA ANALYSIS OF MIXED PARASITE POPULATIONS OF THEILERIA-SERGENTI USING CDNA PROBES ENCODING A MAJOR PIROPLASM SURFACE PROTEIN ANALYSIS OF MIXED PARASITE POPULATIONS OF THEILERIA-SERGENTI USING CDNA PROBES ENCODING A MAJOR PIROPLASM SURFACE PROTEIN ANALYSIS OF MIXED PARASITE POPULATIONS OF THEILERIA-SERGENTI USING CDNA PROBES ENCODING A MAJOR PIROPLASM SURFACE PROTEIN PARASITOLOGY, 107, 4, 369-377 PARASITOLOGY, 107, 4, 369-377 PARASITOLOGY, 107, 4, 369-377 1993/11 英語 研究論文(学術雑誌) 公開
H. Kubota, H. Okazaki, M. Onuma, S. Kano, M. Hattori, N. Minato H. Kubota, H. Okazaki, M. Onuma, S. Kano, M. Hattori, N. Minato H KUBOTA, H OKAZAKI, M ONUMA, S KANO, M HATTORI, N MINATO CD3<sup>+</sup>4<sup>-</sup>8<sup>-</sup> αβ T cell population with biased T cell receptor v gene usage: Presence in bone marrow and possible involvement of IL-3 for their extrathymic development CD3<sup>+</sup>4<sup>-</sup>8<sup>-</sup> αβ T cell population with biased T cell receptor v gene usage: Presence in bone marrow and possible involvement of IL-3 for their extrathymic development CD3+4-8- ALPHA-BETA-T-CELL POPULATION WITH BIASED T-CELL RECEPTOR V-GENE USAGE - PRESENCE IN BONE-MARROW AND POSSIBLE INVOLVEMENT OF IL-3 FOR THEIR EXTRATHYMIC DEVELOPMENT Journal of Immunology, 149, 4, 1143-1150 Journal of Immunology, 149, 4, 1143-1150 JOURNAL OF IMMUNOLOGY, 149, 4, 1143-1150 1992/08 英語 研究論文(学術雑誌) 公開
WZ ZHUANG, M HATTORI, M ONUMA, H KODAMA WZ ZHUANG, M HATTORI, M ONUMA, H KODAMA WZ ZHUANG, M HATTORI, M ONUMA, H KODAMA SENSITIVE METHOD FOR THE DETECTION OF ANTIBODIES TO INFECTIOUS HEMATOPOIETIC NECROSIS VIRUS SENSITIVE METHOD FOR THE DETECTION OF ANTIBODIES TO INFECTIOUS HEMATOPOIETIC NECROSIS VIRUS SENSITIVE METHOD FOR THE DETECTION OF ANTIBODIES TO INFECTIOUS HEMATOPOIETIC NECROSIS VIRUS JOURNAL OF VETERINARY MEDICAL SCIENCE, 54, 2, 371-373 JOURNAL OF VETERINARY MEDICAL SCIENCE, 54, 2, 371-373 JOURNAL OF VETERINARY MEDICAL SCIENCE, 54, 2, 371-373 1992/04 英語 公開
M NIIKURA, Y MATSUURA, M HATTORI, M ONUMA, T MIKAMI M NIIKURA, Y MATSUURA, M HATTORI, M ONUMA, T MIKAMI M NIIKURA, Y MATSUURA, M HATTORI, M ONUMA, T MIKAMI CHARACTERIZATION OF HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN OF NEWCASTLE-DISEASE VIRUS EXPRESSED BY A RECOMBINANT BACULOVIRUS CHARACTERIZATION OF HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN OF NEWCASTLE-DISEASE VIRUS EXPRESSED BY A RECOMBINANT BACULOVIRUS CHARACTERIZATION OF HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN OF NEWCASTLE-DISEASE VIRUS EXPRESSED BY A RECOMBINANT BACULOVIRUS VIRUS RESEARCH, 20, 1, 31-43 VIRUS RESEARCH, 20, 1, 31-43 VIRUS RESEARCH, 20, 1, 31-43 1991/06 英語 研究論文(学術雑誌) 公開
M NIIKURA, Y MATSUURA, M HATTORI, M ONUMA, T MIKAMI M NIIKURA, Y MATSUURA, M HATTORI, M ONUMA, T MIKAMI M NIIKURA, Y MATSUURA, M HATTORI, M ONUMA, T MIKAMI EXPRESSION OF THE A-ANTIGEN (GP57-65) OF MAREKS-DISEASE VIRUS BY A RECOMBINANT BACULOVIRUS EXPRESSION OF THE A-ANTIGEN (GP57-65) OF MAREKS-DISEASE VIRUS BY A RECOMBINANT BACULOVIRUS EXPRESSION OF THE A-ANTIGEN (GP57-65) OF MAREKS-DISEASE VIRUS BY A RECOMBINANT BACULOVIRUS JOURNAL OF GENERAL VIROLOGY, 72, 5, 1099-1104 JOURNAL OF GENERAL VIROLOGY, 72, 5, 1099-1104 JOURNAL OF GENERAL VIROLOGY, 72, 5, 1099-1104 1991/05 英語 研究論文(学術雑誌) 公開
Y OGAWA, H OKAZAKI, T SUDO, N OHNO, M ITOH, M HATTORI, M IIZUKA, N MINATO Y OGAWA, H OKAZAKI, T SUDO, N OHNO, M ITOH, M HATTORI, M IIZUKA, N MINATO Y OGAWA, H OKAZAKI, T SUDO, N OHNO, M ITOH, M HATTORI, M IIZUKA, N MINATO HIGH-MOLECULAR-WEIGHT LY-5 ISOFORMS EXPRESSED ON T-CELLS - ACTIVATION-DEPENDENT EXPRESSION HIGH-MOLECULAR-WEIGHT LY-5 ISOFORMS EXPRESSED ON T-CELLS - ACTIVATION-DEPENDENT EXPRESSION HIGH-MOLECULAR-WEIGHT LY-5 ISOFORMS EXPRESSED ON T-CELLS - ACTIVATION-DEPENDENT EXPRESSION INTERNATIONAL IMMUNOLOGY, 3, 1, 39-47 INTERNATIONAL IMMUNOLOGY, 3, 1, 39-47 INTERNATIONAL IMMUNOLOGY, 3, 1, 39-47 1991/01 英語 研究論文(学術雑誌) 公開
H KUBOTA, H OKAZAKI, M ONUMA, S KANO, M HATTORI, N MINATO H KUBOTA, H OKAZAKI, M ONUMA, S KANO, M HATTORI, N MINATO H KUBOTA, H OKAZAKI, M ONUMA, S KANO, M HATTORI, N MINATO IDENTIFICATION AND GENE CLONING OF A NEW PHOSPHATIDYLINOSITOL-LINKED ANTIGEN EXPRESSED ON MATURE LYMPHOCYTES - DOWN-REGULATION BY LYMPHOCYTE-ACTIVATION IDENTIFICATION AND GENE CLONING OF A NEW PHOSPHATIDYLINOSITOL-LINKED ANTIGEN EXPRESSED ON MATURE LYMPHOCYTES - DOWN-REGULATION BY LYMPHOCYTE-ACTIVATION IDENTIFICATION AND GENE CLONING OF A NEW PHOSPHATIDYLINOSITOL-LINKED ANTIGEN EXPRESSED ON MATURE LYMPHOCYTES - DOWN-REGULATION BY LYMPHOCYTE-ACTIVATION JOURNAL OF IMMUNOLOGY, 145, 11, 3924-3931 JOURNAL OF IMMUNOLOGY, 145, 11, 3924-3931 JOURNAL OF IMMUNOLOGY, 145, 11, 3924-3931 1990/12 英語 研究論文(学術雑誌) 公開
M. Hattori, H. Okazaki, Y. Ishida, M. Onuma, S. Kano, T. Honjo, N. Minato M. Hattori, H. Okazaki, Y. Ishida, M. Onuma, S. Kano, T. Honjo, N. Minato M HATTORI, H OKAZAKI, Y ISHIDA, M ONUMA, S KANO, T HONJO, N MINATO Expression of murine IL-2 receptor β-chain on thymic and splenic lymphocyte subpopulations as revealed by the IL-2-induced proliferative response in human IL-2 receptor α-chain transgenic mice Expression of murine IL-2 receptor β-chain on thymic and splenic lymphocyte subpopulations as revealed by the IL-2-induced proliferative response in human IL-2 receptor α-chain transgenic mice EXPRESSION OF MURINE IL-2-RECEPTOR BETA-CHAIN ON THYMIC AND SPLENIC LYMPHOCYTE SUBPOPULATIONS AS REVEALED BY THE IL-2-INDUCED PROLIFERATIVE RESPONSE IN HUMAN IL-2-RECEPTOR ALPHA-CHAIN TRANSGENIC MICE Journal of Immunology, 144, 10, 3809-3815 Journal of Immunology, 144, 10, 3809-3815 JOURNAL OF IMMUNOLOGY, 144, 10, 3809-3815 1990/05 英語 研究論文(学術雑誌) 公開
R SAWADA, K OHASHI, H ANAGUCHI, H OKAZAKI, M HATTORI, N MINATO, M NARUTO R SAWADA, K OHASHI, H ANAGUCHI, H OKAZAKI, M HATTORI, N MINATO, M NARUTO R SAWADA, K OHASHI, H ANAGUCHI, H OKAZAKI, M HATTORI, N MINATO, M NARUTO ISOLATION AND EXPRESSION OF THE FULL-LENGTH CDNA-ENCODING CD59 ANTIGEN OF HUMAN-LYMPHOCYTES ISOLATION AND EXPRESSION OF THE FULL-LENGTH CDNA-ENCODING CD59 ANTIGEN OF HUMAN-LYMPHOCYTES ISOLATION AND EXPRESSION OF THE FULL-LENGTH CDNA-ENCODING CD59 ANTIGEN OF HUMAN-LYMPHOCYTES DNA AND CELL BIOLOGY, 9, 3, 213-220 DNA AND CELL BIOLOGY, 9, 3, 213-220 DNA AND CELL BIOLOGY, 9, 3, 213-220 1990/04 英語 研究論文(学術雑誌) 公開
T KONDO, M HATTORI, H KODAMA, M ONUMA, T MIKAMI T KONDO, M HATTORI, H KODAMA, M ONUMA, T MIKAMI T KONDO, M HATTORI, H KODAMA, M ONUMA, T MIKAMI PRODUCTION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES AGAINST CHICKEN LYMPHOCYTE SURFACE-ANTIGENS PRODUCTION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES AGAINST CHICKEN LYMPHOCYTE SURFACE-ANTIGENS PRODUCTION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES AGAINST CHICKEN LYMPHOCYTE SURFACE-ANTIGENS JAPANESE JOURNAL OF VETERINARY SCIENCE, 52, 1, 97-103 JAPANESE JOURNAL OF VETERINARY SCIENCE, 52, 1, 97-103 JAPANESE JOURNAL OF VETERINARY SCIENCE, 52, 1, 97-103 1990/02 英語 研究論文(学術雑誌) 公開
T. Kondo, M. Hattori, H. Kodama, M. Onuma, T. Mikami T. Kondo, M. Hattori, H. Kodama, M. Onuma, T. Mikami T. Kondo, M. Hattori, H. Kodama, M. Onuma, T. Mikami Characterization of two monoclonal antibodies which recognize different subpopulations of chicken T lymphocytes. Characterization of two monoclonal antibodies which recognize different subpopulations of chicken T lymphocytes. Characterization of two monoclonal antibodies which recognize different subpopulations of chicken T lymphocytes. Japanese Journal of Veterinary Research, 38, 1, 11-17 Japanese Journal of Veterinary Research, 38, 1, 11-17 Japanese Journal of Veterinary Research, 38, 1, 11-17 1990 英語 公開
H. Okazaki, M. Ito, T. Sudo, M. Hattori, S. Kano, Y. Katsura, N. Minato H. Okazaki, M. Ito, T. Sudo, M. Hattori, S. Kano, Y. Katsura, N. Minato H OKAZAKI, M ITO, T SUDO, M HATTORI, S KANO, Y KATSURA, N MINATO IL-7 promotes thymocyte proliferation and maintains immunocompetent thymocytes bearing αβ or γδ T-cell receptors in vitro: Synergism with IL-2 IL-7 promotes thymocyte proliferation and maintains immunocompetent thymocytes bearing αβ or γδ T-cell receptors in vitro: Synergism with IL-2 IL-7 PROMOTES THYMOCYTE PROLIFERATION AND MAINTAINS IMMUNOCOMPETENT THYMOCYTES BEARING ALPHA-BETA-T-CELL OR GAMMA-DELTA-T-CELL RECEPTORS INVITRO - SYNERGISM WITH IL-2 Journal of Immunology, 143, 9, 2917-2922 Journal of Immunology, 143, 9, 2917-2922 JOURNAL OF IMMUNOLOGY, 143, 9, 2917-2922 1989/11 英語 研究論文(学術雑誌) 公開
Y ISHIDA, M NISHI, O TAGUCHI, K INABA, M HATTORI, N MINATO, M KAWAICHI, T HONJO Y ISHIDA, M NISHI, O TAGUCHI, K INABA, M HATTORI, N MINATO, M KAWAICHI, T HONJO Y ISHIDA, M NISHI, O TAGUCHI, K INABA, M HATTORI, N MINATO, M KAWAICHI, T HONJO EXPANSION OF NATURAL-KILLER CELLS BUT NOT T-CELLS IN HUMAN INTERLEUKIN-2 INTERLEUKIN-2 RECEPTOR (TAC) TRANSGENIC MICE EXPANSION OF NATURAL-KILLER CELLS BUT NOT T-CELLS IN HUMAN INTERLEUKIN-2 INTERLEUKIN-2 RECEPTOR (TAC) TRANSGENIC MICE EXPANSION OF NATURAL-KILLER CELLS BUT NOT T-CELLS IN HUMAN INTERLEUKIN-2 INTERLEUKIN-2 RECEPTOR (TAC) TRANSGENIC MICE JOURNAL OF EXPERIMENTAL MEDICINE, 170, 4, 1103-1115 JOURNAL OF EXPERIMENTAL MEDICINE, 170, 4, 1103-1115 JOURNAL OF EXPERIMENTAL MEDICINE, 170, 4, 1103-1115 1989/10 英語 研究論文(学術雑誌) 公開
Masakazu Hattori, Tetsuo Sudo, Hisao Izawa, Shogo Kano, Nagahiro Minato Masakazu Hattori, Tetsuo Sudo, Hisao Izawa, Shogo Kano, Nagahiro Minato Masakazu Hattori, Tetsuo Sudo, Hisao Izawa, Shogo Kano, Nagahiro Minato Developmental regulation of the extrathymic differentiation potential of the progenitor cells for T cell lineage Developmental regulation of the extrathymic differentiation potential of the progenitor cells for T cell lineage Developmental regulation of the extrathymic differentiation potential of the progenitor cells for T cell lineage International Immunology, 1, 2, 151-159 International Immunology, 1, 2, 151-159 International Immunology, 1, 2, 151-159 1989/05 英語 研究論文(学術雑誌) 公開
R. Sawada, K. Ohashi, K. Okano, M. Hattori, N. Minato, M. Naruto R. Sawada, K. Ohashi, K. Okano, M. Hattori, N. Minato, M. Naruto R. Sawada, K. Ohashi, K. Okano, M. Hattori, N. Minato, M. Naruto Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C Nucleic Acids Research, 17, 16, 6728- Nucleic Acids Research, 17, 16, 6728- Nucleic Acids Research, 17, 16, 6728- 1989 英語 公開
N MINATO, M HATTORI, T SUDO, S KANO, Y MIURA, J SUDA, T SUDA N MINATO, M HATTORI, T SUDO, S KANO, Y MIURA, J SUDA, T SUDA N MINATO, M HATTORI, T SUDO, S KANO, Y MIURA, J SUDA, T SUDA DIFFERENTIATION INVITRO OF T3+ LARGE GRANULAR LYMPHOCYTES WITH CHARACTERISTIC CYTO-TOXIC ACTIVITY FROM AN ISOLATED HEMATOPOIETIC PROGENITOR COLONY DIFFERENTIATION INVITRO OF T3+ LARGE GRANULAR LYMPHOCYTES WITH CHARACTERISTIC CYTO-TOXIC ACTIVITY FROM AN ISOLATED HEMATOPOIETIC PROGENITOR COLONY DIFFERENTIATION INVITRO OF T3+ LARGE GRANULAR LYMPHOCYTES WITH CHARACTERISTIC CYTO-TOXIC ACTIVITY FROM AN ISOLATED HEMATOPOIETIC PROGENITOR COLONY JOURNAL OF EXPERIMENTAL MEDICINE, 167, 3, 762-776 JOURNAL OF EXPERIMENTAL MEDICINE, 167, 3, 762-776 JOURNAL OF EXPERIMENTAL MEDICINE, 167, 3, 762-776 1988/03 英語 研究論文(学術雑誌) 公開
M. Hattori, T. Udo, M. Iizuka, S. Kobayashi, S. Nishio, S. Kano, N. Minato M. Hattori, T. Udo, M. Iizuka, S. Kobayashi, S. Nishio, S. Kano, N. Minato M. Hattori, T. Udo, M. Iizuka, S. Kobayashi, S. Nishio, S. Kano, N. Minato Generation of continuous large granular lymphocyte lines by interleukin 2 from the spleen cells of mice infected with Moloney leukemia virus. Involvement of interleukin 3 Generation of continuous large granular lymphocyte lines by interleukin 2 from the spleen cells of mice infected with Moloney leukemia virus. Involvement of interleukin 3 Generation of continuous large granular lymphocyte lines by interleukin 2 from the spleen cells of mice infected with Moloney leukemia virus. Involvement of interleukin 3 Journal of Experimental Medicine, 166, 4, 833-849 Journal of Experimental Medicine, 166, 4, 833-849 Journal of Experimental Medicine, 166, 4, 833-849 1987 英語 公開
K. Ikuta, M. Hattori, K. Wake, S. Kano, T. Honjo, J. Yodoi, N. Minato K. Ikuta, M. Hattori, K. Wake, S. Kano, T. Honjo, J. Yodoi, N. Minato K. Ikuta, M. Hattori, K. Wake, S. Kano, T. Honjo, J. Yodoi, N. Minato Expression and rearrangement of the α, β, and γ chain genes of the T cell receptor in cloned murine large granular lymphocyte lines Expression and rearrangement of the α, β, and γ chain genes of the T cell receptor in cloned murine large granular lymphocyte lines Expression and rearrangement of the α, β, and γ chain genes of the T cell receptor in cloned murine large granular lymphocyte lines Journal of Experimental Medicine, 164, 2, 428-442 Journal of Experimental Medicine, 164, 2, 428-442 Journal of Experimental Medicine, 164, 2, 428-442 1986 英語 公開

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タイトル言語:
Misc
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
K. Shimatani, Y. Nakashima, M. Hattori, Y. Hamazaki, N. Minato K. Shimatani, Y. Nakashima, M. Hattori, Y. Hamazaki, N. Minato Kenichiro Shimatani, Yasuhiro Nakashima, Masakazu Hattori, Yoko Hamazaki, Nagahiro Minato PD-1<sup>+</sup> memory phenotype CD4<sup>+</sup> T cells expressing C/EBPα underlie T cell immunodepression in senescence and leukemia PD-1<sup>+</sup> memory phenotype CD4<sup>+</sup> T cells expressing C/EBPα underlie T cell immunodepression in senescence and leukemia PD-1(+) memory phenotype CD4(+) T cells expressing C/EBP alpha underlie T cell immunodepression in senescence and leukemia Proceedings of the National Academy of Sciences of the United States of America, 106, 37, 15807-15812 Proceedings of the National Academy of Sciences of the United States of America, 106, 37, 15807-15812 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106, 37, 15807-15812 2009/09 英語 公開
D Ishida, HL Yang, K Masuda, K Uesugi, H Kawamoto, M Hattori, N Minato D Ishida, HL Yang, K Masuda, K Uesugi, H Kawamoto, M Hattori, N Minato D Ishida, HL Yang, K Masuda, K Uesugi, H Kawamoto, M Hattori, N Minato Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100, 19, 10919-10924 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100, 19, 10919-10924 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100, 19, 10919-10924 2003/09 英語 公開
タイトル言語:
講演・口頭発表等
タイトル タイトル(日本語) タイトル(英語) 会議名 会議名(日本語) 会議名(英語) 主催者 主催者(日本語) 主催者(英語) 発表年月日 記述言語 会議種別 公開
老化関連T細胞の誘導メカニズムとその制御[招待あり] 老化関連T細胞の誘導メカニズムとその制御 [招待あり] 日本炎症・再生医学会 日本炎症・再生医学会 2017/07/18 日本語 口頭発表(招待・特別) 公開
タイトル言語:
産業財産権 (特許)
発明者 発明者(日本語) 発明者(英語) 発明の名称 発明の名称(日本語) 発明の名称(英語) 審査の段階 番号 年月 公開
服部雅一, 井上 浄, 赤澤悠子 服部雅一, 井上 浄, 赤澤悠子 抗原特異的モノクローナル抗体産生ハイブリドーマの作成方法及び抗原特異的モノクローナル抗体の製造作成 抗原特異的モノクローナル抗体産生ハイブリドーマの作成方法及び抗原特異的モノクローナル抗体の製造作成 特許登録 特許5996437 2016/09/02 公開
宮下武憲, 森望,西望, 安達栄治郎, 松下治, 服部雅一, 伊藤周平, 坂本恵子 宮下武憲, 森望,西望, 安達栄治郎, 松下治, 服部雅一, 伊藤周平, 坂本恵子 粘膜,上皮および鼓膜の少なくとも一つの再生材および再生評価方法 粘膜,上皮および鼓膜の少なくとも一つの再生材および再生評価方法 特許出願 特願2010-110694 2010/05/12 公開
SPA-1蛋白質及びそれをコードする遺伝子 SPA-1蛋白質及びそれをコードする遺伝子 特許登録 特許3683000 公開
タイトル言語:
外部資金:競争的資金 (科学研究費補助金)
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
基盤研究(B) 代表 がん・病原微生物によるT細胞機能抑制の分子メカニズム解明とその制御 
1. 挑戦的萌芽研究 代表 「人工リンパ節技術を用いた新規アジュバントの開発と高機能型抗体の作製」
2  基盤研究(B) 代表 「がん・病原微生物によるT細胞機能抑制の分子メカニズム解明とその制御」
3. 基盤研究(B) 分担 「コラーゲン細線維の積層と細胞成長因子の固相化による人工組織の実用化に関する研究」
4. 基盤研究(A) 分担 「比較ゲノム解析によるタイレリア原虫病原性進化の解明」
基盤研究(C) 代表 免疫老化の分子メカニズムの解明とワクチン開発への応用 (平成26年度分) 2014/04/01〜2015/03/31
基盤研究(C) 代表 免疫老化の分子メカニズムの解明とワクチン開発への応用 (平成27年度分) 2015/04/01〜2016/03/31
基盤研究(C) 代表 免疫老化の分子メカニズムの解明とワクチン開発への応用 (平成28年度分) 2016/04/01〜2017/03/31
基盤研究(B) 代表 老化関連T細胞誘導メカニズムの解明と人為的制御 (平成29年度分) 2017/04/01〜2018/03/31
挑戦的研究(萌芽) 代表 メモリーT細胞を直接標的とした新規アジュバントの創出 (平成30年度分) 2018/04/01〜2019/03/31
挑戦的研究(萌芽) 代表 メモリーT細胞を直接標的とした新規アジュバントの創出 (2019年度分) 2019/04/01〜2020/03/31
基盤研究(B) 代表 老化関連T細胞誘導メカニズムの解明と人為的制御 (2019年度分) 2019/04/01〜2020/03/31

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