手塚 徹

最終更新日時: 2021/06/29 18:51:53

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氏名(漢字/フリガナ/アルファベット表記)
手塚 徹/テヅカ トオル/Tezuka, Toru
所属部署・職名(部局/所属/講座等/職名)
学際融合教育研究推進センター/スーパーグローバルコース医学生命系ユニット/特定講師
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
博士(理学) 東京大学
使用言語
言語名(japanese) 言語名(english) コード
英語 English eng
日本語 Japanese jpn
researchmap URL
https://researchmap.jp/read0213396
研究テーマ
(日本語)
ユビキチン化システムの生理機能とその作用機序
(英語)
Roles and mechanism of the ubiquitination system
研究概要
(日本語)
蛋白質のユビキチン化は様々な高次生理機能に関わっていることが知られているが、ユビキチン化関連蛋白質は極めて多く存在し、それらの役割は不明なものが多い。そこで、機能未解明のユビキチン化関連蛋白質の解析を起点として、高次生理機能の分子機構を明らかにする。
(英語)
Many proteins are involved in protein ubiquitination events, but roles of these proteins are not well understood. I will elucidate the mechanisms underlying various physiological functions through the analysis of ubiquitination-related proteins.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
ユビキチン化 ubiquitination
分子生物学 Molecular Biology
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Sadanori Miyoshi, Tohru Tezuka, Sumimasa Arimura, Taro Tomono, Takashi Okada, Yuji Yamanashi Sadanori Miyoshi, Tohru Tezuka, Sumimasa Arimura, Taro Tomono, Takashi Okada, Yuji Yamanashi Sadanori Miyoshi, Tohru Tezuka, Sumimasa Arimura, Taro Tomono, Takashi Okada, Yuji Yamanashi DOK7 gene therapy enhances motor activity and life span in ALS model mice DOK7 gene therapy enhances motor activity and life span in ALS model mice DOK7 gene therapy enhances motor activity and life span in ALS model mice EMBO MOLECULAR MEDICINE, 9, 7, 880-889 EMBO MOLECULAR MEDICINE, 9, 7, 880-889 EMBO MOLECULAR MEDICINE, 9, 7, 880-889 2017/07 英語 研究論文(学術雑誌) 公開
Ryo Ueta, Tohru Tezuka, Yosuke Izawa, Sadanori Miyoshi, Satoru Nagatoishi, Kouhei Tsumoto, Yuji Yamanashi Ryo Ueta, Tohru Tezuka, Yosuke Izawa, Sadanori Miyoshi, Satoru Nagatoishi, Kouhei Tsumoto, Yuji Yamanashi Ryo Ueta, Tohru Tezuka, Yosuke Izawa, Sadanori Miyoshi, Satoru Nagatoishi, Kouhei Tsumoto, Yuji Yamanashi The carboxyl-terminal region of Dok-7 plays a key, but not essential, role in activation of muscle-specific receptor kinase MuSK and neuromuscular synapse formation The carboxyl-terminal region of Dok-7 plays a key, but not essential, role in activation of muscle-specific receptor kinase MuSK and neuromuscular synapse formation The carboxyl-terminal region of Dok-7 plays a key, but not essential, role in activation of muscle-specific receptor kinase MuSK and neuromuscular synapse formation JOURNAL OF BIOCHEMISTRY, 161, 3, 269-277 JOURNAL OF BIOCHEMISTRY, 161, 3, 269-277 JOURNAL OF BIOCHEMISTRY, 161, 3, 269-277 2017/03 英語 研究論文(学術雑誌) 公開
Eguchi T, Tezuka T, Miyoshi S, Yamanashi Y Eguchi T, Tezuka T, Miyoshi S, Yamanashi Y Eguchi T, Tezuka T, Miyoshi S, Yamanashi Y [Molecular mechanisms underlying the formation and maintenance of neuromuscular junctions and a possible therapeutic approach.] [Molecular mechanisms underlying the formation and maintenance of neuromuscular junctions and a possible therapeutic approach.] [Molecular mechanisms underlying the formation and maintenance of neuromuscular junctions and a possible therapeutic approach.] Clinical calcium, 27, 3, 413-419 Clinical calcium, 27, 3, 413-419 Clinical calcium, 27, 3, 413-419 2017 公開
Takahiro Eguchi, Tohru Tezuka, Sadanori Miyoshi, Yuji Yamanashi Takahiro Eguchi, Tohru Tezuka, Sadanori Miyoshi, Yuji Yamanashi Takahiro Eguchi, Tohru Tezuka, Sadanori Miyoshi, Yuji Yamanashi Postnatal knockdown of dok-7 gene expression in mice causes structural defects in neuromuscular synapses and myasthenic pathology Postnatal knockdown of dok-7 gene expression in mice causes structural defects in neuromuscular synapses and myasthenic pathology Postnatal knockdown of dok-7 gene expression in mice causes structural defects in neuromuscular synapses and myasthenic pathology GENES TO CELLS, 21, 6, 670-676 GENES TO CELLS, 21, 6, 670-676 GENES TO CELLS, 21, 6, 670-676 2016/06 英語 研究論文(学術雑誌) 公開
Tohru Tezuka, Akane Inoue, Taisuke Hoshi, Scott D. Weatherbee, Robert W. Burgess, Ryo Ueta, Yuji Yamanashi Tohru Tezuka, Akane Inoue, Taisuke Hoshi, Scott D. Weatherbee, Robert W. Burgess, Ryo Ueta, Yuji Yamanashi Tohru Tezuka, Akane Inoue, Taisuke Hoshi, Scott D. Weatherbee, Robert W. Burgess, Ryo Ueta, Yuji Yamanashi The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111, 46, 16556-16561 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111, 46, 16556-16561 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111, 46, 16556-16561 2014/11 英語 研究論文(学術雑誌) 公開
Sumimasa Arimura, Takashi Okada, Tohru Tezuka, Tomoko Chiyo, Yuko Kasahara, Toshiro Yoshimura, Masakatsu Motomura, Nobuaki Yoshida, David Beeson, Shin'ichi Takeda, Yuji Yamanashi Sumimasa Arimura, Takashi Okada, Tohru Tezuka, Tomoko Chiyo, Yuko Kasahara, Toshiro Yoshimura, Masakatsu Motomura, Nobuaki Yoshida, David Beeson, Shin'ichi Takeda, Yuji Yamanashi Sumimasa Arimura, Takashi Okada, Tohru Tezuka, Tomoko Chiyo, Yuko Kasahara, Toshiro Yoshimura, Masakatsu Motomura, Nobuaki Yoshida, David Beeson, Shin'ichi Takeda, Yuji Yamanashi DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction SCIENCE, 345, 6203, 1505-1508 SCIENCE, 345, 6203, 1505-1508 SCIENCE, 345, 6203, 1505-1508 2014/09 英語 研究論文(学術雑誌) 公開
Taisuke Hoshi, Tohru Tezuka, Kazumasa Yokoyama, Shun-Ichiro Iemura, Tohru Natsume, Yuji Yamanashi Taisuke Hoshi, Tohru Tezuka, Kazumasa Yokoyama, Shun-Ichiro Iemura, Tohru Natsume, Yuji Yamanashi Taisuke Hoshi, Tohru Tezuka, Kazumasa Yokoyama, Shun-Ichiro Iemura, Tohru Natsume, Yuji Yamanashi Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes FEBS Letters, 587, 23, 3749-3754 FEBS Letters, 587, 23, 3749-3754 FEBS Letters, 587, 23, 3749-3754 2013/11/29 英語 研究論文(学術雑誌) 公開
Naosuke Hoshina, Asami Tanimura, Miwako Yamasaki, Takeshi Inoue, Ryoji Fukabori, Teiko Kuroda, Kazumasa Yokoyama, Tohru Tezuka, Hiroshi Sagara, Shinji Hirano, Hiroshi Kiyonari, Masahiko Takada, Kazuto Kobayashi, Masahiko Watanabe, Masanobu Kano, Takanobu Nakazawa, Tadashi Yamamoto Naosuke Hoshina, Asami Tanimura, Miwako Yamasaki, Takeshi Inoue, Ryoji Fukabori, Teiko Kuroda, Kazumasa Yokoyama, Tohru Tezuka, Hiroshi Sagara, Shinji Hirano, Hiroshi Kiyonari, Masahiko Takada, Kazuto Kobayashi, Masahiko Watanabe, Masanobu Kano, Takanobu Nakazawa, Tadashi Yamamoto Naosuke Hoshina, Asami Tanimura, Miwako Yamasaki, Takeshi Inoue, Ryoji Fukabori, Teiko Kuroda, Kazumasa Yokoyama, Tohru Tezuka, Hiroshi Sagara, Shinji Hirano, Hiroshi Kiyonari, Masahiko Takada, Kazuto Kobayashi, Masahiko Watanabe, Masanobu Kano, Takanobu Nakazawa, Tadashi Yamamoto Protocadherin 17 Regulates Presynaptic Assembly in Topographic Corticobasal Ganglia Circuits Protocadherin 17 Regulates Presynaptic Assembly in Topographic Corticobasal Ganglia Circuits Protocadherin 17 Regulates Presynaptic Assembly in Topographic Corticobasal Ganglia Circuits NEURON, 78, 5, 839-854 NEURON, 78, 5, 839-854 NEURON, 78, 5, 839-854 2013/06 英語 研究論文(学術雑誌) 公開
Minegishi Y, Shibagaki Y, Mizutani A, Fujita K, Tezuka T, Kinoshita M, Kuroda M, Hattori S, Gotoh N Minegishi Y, Shibagaki Y, Mizutani A, Fujita K, Tezuka T, Kinoshita M, Kuroda M, Hattori S, Gotoh N Yuriko Minegishi, Yoshio Shibagaki, Anna Mizutani, Koji Fujita, Tohru Tezuka, Masao Kinoshita, Masahiko Kuroda, Seisuke Hattori, Noriko Gotoh Adaptor protein complex of FRS2β and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation. Adaptor protein complex of FRS2β and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation. Adaptor protein complex of FRS2 beta and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation Cancer science, 104, 3, 345-352 Cancer science, 104, 3, 345-352 CANCER SCIENCE, 104, 3, 345-352 2013/03 英語 研究論文(学術雑誌) 公開
Kohei Takeshita, Tohru Tezuka, Yukari Isozaki, Eiki Yamashita, Mamoru Suzuki, Minsoo Kim, Yuji Yamanashi, Tadashi Yamamoto, Atsushi Nakagawa Kohei Takeshita, Tohru Tezuka, Yukari Isozaki, Eiki Yamashita, Mamoru Suzuki, Minsoo Kim, Yuji Yamanashi, Tadashi Yamamoto, Atsushi Nakagawa Kohei Takeshita, Tohru Tezuka, Yukari Isozaki, Eiki Yamashita, Mamoru Suzuki, Minsoo Kim, Yuji Yamanashi, Tadashi Yamamoto, Atsushi Nakagawa Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c JOURNAL OF BIOCHEMISTRY, 152, 5, 487-495 JOURNAL OF BIOCHEMISTRY, 152, 5, 487-495 JOURNAL OF BIOCHEMISTRY, 152, 5, 487-495 2012/11 英語 研究論文(学術雑誌) 公開
Mina Delawary, Tohru Tezuka, Yuji Kiyama, Kazumasa Yokoyama, Etsuko Wada, Keiji Wada, Toshiya Manabe, Tadashi Yamamoto, Takanobu Nakazawa Mina Delawary, Tohru Tezuka, Yuji Kiyama, Kazumasa Yokoyama, Etsuko Wada, Keiji Wada, Toshiya Manabe, Tadashi Yamamoto, Takanobu Nakazawa Mina Delawary, Tohru Tezuka, Yuji Kiyama, Kazumasa Yokoyama, Etsuko Wada, Keiji Wada, Toshiya Manabe, Tadashi Yamamoto, Takanobu Nakazawa NMDAR2B tyrosine phosphorylation is involved in thermal nociception NMDAR2B tyrosine phosphorylation is involved in thermal nociception NMDAR2B tyrosine phosphorylation is involved in thermal nociception NEUROSCIENCE LETTERS, 516, 2, 270-273 NEUROSCIENCE LETTERS, 516, 2, 270-273 NEUROSCIENCE LETTERS, 516, 2, 270-273 2012/05 英語 研究論文(学術雑誌) 公開
Yuji Yamanashi, Tohru Tezuka, Kazumasa Yokoyama Yuji Yamanashi, Tohru Tezuka, Kazumasa Yokoyama Yuji Yamanashi, Tohru Tezuka, Kazumasa Yokoyama Activation of receptor protein-tyrosine kinases from the cytoplasmic compartment Activation of receptor protein-tyrosine kinases from the cytoplasmic compartment Activation of receptor protein-tyrosine kinases from the cytoplasmic compartment JOURNAL OF BIOCHEMISTRY, 151, 4, 353-359 JOURNAL OF BIOCHEMISTRY, 151, 4, 353-359 JOURNAL OF BIOCHEMISTRY, 151, 4, 353-359 2012/04 英語 公開
Kazumasa Yokoyama, Tohru Tezuka, Masaharu Kotani, Takanobu Nakazawa, Naosuke Hoshina, Yasushi Shimoda, Shigeru Kakuta, Katsuko Sudo, Kazutada Watanabe, Yoichiro Iwakura, Tadashi Yamamoto Kazumasa Yokoyama, Tohru Tezuka, Masaharu Kotani, Takanobu Nakazawa, Naosuke Hoshina, Yasushi Shimoda, Shigeru Kakuta, Katsuko Sudo, Kazutada Watanabe, Yoichiro Iwakura, Tadashi Yamamoto Kazumasa Yokoyama, Tohru Tezuka, Masaharu Kotani, Takanobu Nakazawa, Naosuke Hoshina, Yasushi Shimoda, Shigeru Kakuta, Katsuko Sudo, Kazutada Watanabe, Yoichiro Iwakura, Tadashi Yamamoto NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons EMBO JOURNAL, 30, 23, 4739-4754 EMBO JOURNAL, 30, 23, 4739-4754 EMBO JOURNAL, 30, 23, 4739-4754 2011/11 英語 研究論文(学術雑誌) 公開
Mina Delawary, Tohru Tezuka, Yuji Kiyama, Kazumasa Yokoyama, Takeshi Inoue, Satoko Hattori, Ryota Hashimoto, Hisashi Umemori, Toshiya Manabe, Tadashi Yamamoto, Takanobu Nakazawa Mina Delawary, Tohru Tezuka, Yuji Kiyama, Kazumasa Yokoyama, Takeshi Inoue, Satoko Hattori, Ryota Hashimoto, Hisashi Umemori, Toshiya Manabe, Tadashi Yamamoto, Takanobu Nakazawa Mina Delawary, Tohru Tezuka, Yuji Kiyama, Kazumasa Yokoyama, Takeshi Inoue, Satoko Hattori, Ryota Hashimoto, Hisashi Umemori, Toshiya Manabe, Tadashi Yamamoto, Takanobu Nakazawa NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala MOLECULAR BRAIN, 3, 37 MOLECULAR BRAIN, 3, 37 MOLECULAR BRAIN, 3, 37 2010 英語 研究論文(学術雑誌) 公開
Sachiko Taniguchi, Takanobu Nakazawa, Asami Tanimura, Yuji Kiyama, Tohru Tezuka, Ayako M. Watabe, Norikazu Katayama, Kazumasa Yokoyama, Takeshi Inoue, Hiroko Izumi-Nakaseko, Shigeru Kakuta, Katsuko Sudo, Yoichiro Iwakura, Hisashi Umemori, Takafumi Inoue, Niall P. Murphy, Kouichi Hashimoto, Masanobu Kano, Toshiya Manabe, Tadashi Yamamoto Sachiko Taniguchi, Takanobu Nakazawa, Asami Tanimura, Yuji Kiyama, Tohru Tezuka, Ayako M. Watabe, Norikazu Katayama, Kazumasa Yokoyama, Takeshi Inoue, Hiroko Izumi-Nakaseko, Shigeru Kakuta, Katsuko Sudo, Yoichiro Iwakura, Hisashi Umemori, Takafumi Inoue, Niall P. Murphy, Kouichi Hashimoto, Masanobu Kano, Toshiya Manabe, Tadashi Yamamoto Sachiko Taniguchi, Takanobu Nakazawa, Asami Tanimura, Yuji Kiyama, Tohru Tezuka, Ayako M. Watabe, Norikazu Katayama, Kazumasa Yokoyama, Takeshi Inoue, Hiroko Izumi-Nakaseko, Shigeru Kakuta, Katsuko Sudo, Yoichiro Iwakura, Hisashi Umemori, Takafumi Inoue, Niall P. Murphy, Kouichi Hashimoto, Masanobu Kano, Toshiya Manabe, Tadashi Yamamoto Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour EMBO JOURNAL, 28, 23, 3717-3729 EMBO JOURNAL, 28, 23, 3717-3729 EMBO JOURNAL, 28, 23, 3717-3729 2009/12 英語 研究論文(学術雑誌) 公開
Ryuichi Mashima, Yukihiro Hishida, Tohru Tezuka, Yuji Yamanashi Ryuichi Mashima, Yukihiro Hishida, Tohru Tezuka, Yuji Yamanashi Ryuichi Mashima, Yukihiro Hishida, Tohru Tezuka, Yuji Yamanashi The roles of Dok family adapters in immunoreceptor signaling The roles of Dok family adapters in immunoreceptor signaling The roles of Dok family adapters in immunoreceptor signaling IMMUNOLOGICAL REVIEWS, 232, 1, 273-285 IMMUNOLOGICAL REVIEWS, 232, 1, 273-285 IMMUNOLOGICAL REVIEWS, 232, 1, 273-285 2009/11 英語 公開
Yutaka Harita, Hidetake Kurihara, Hidetaka Kosako, Tohru Tezuka, Takashi Sekine, Takashi Igarashi, Ikuroh Ohsawa, Shigeo Ohta, Seisuke Hattori Yutaka Harita, Hidetake Kurihara, Hidetaka Kosako, Tohru Tezuka, Takashi Sekine, Takashi Igarashi, Ikuroh Ohsawa, Shigeo Ohta, Seisuke Hattori Yutaka Harita, Hidetake Kurihara, Hidetaka Kosako, Tohru Tezuka, Takashi Sekine, Takashi Igarashi, Ikuroh Ohsawa, Shigeo Ohta, Seisuke Hattori Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-gamma 1 Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-gamma 1 Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-gamma 1 JOURNAL OF BIOLOGICAL CHEMISTRY, 284, 13, 8951-8962 JOURNAL OF BIOLOGICAL CHEMISTRY, 284, 13, 8951-8962 JOURNAL OF BIOLOGICAL CHEMISTRY, 284, 13, 8951-8962 2009/03 英語 研究論文(学術雑誌) 公開
June Goto, Tohru Tezuka, Takanobu Nakazawa, Hiroshi Sagara, Tadashi Yamamoto June Goto, Tohru Tezuka, Takanobu Nakazawa, Hiroshi Sagara, Tadashi Yamamoto June Goto, Tohru Tezuka, Takanobu Nakazawa, Hiroshi Sagara, Tadashi Yamamoto Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development MOLECULAR AND CELLULAR NEUROSCIENCE, 38, 2, 203-212 MOLECULAR AND CELLULAR NEUROSCIENCE, 38, 2, 203-212 MOLECULAR AND CELLULAR NEUROSCIENCE, 38, 2, 203-212 2008/06 英語 研究論文(学術雑誌) 公開
Takanobu Nakazawa, Toshihiko Kuriu, Tohru Tezuka, Hisashi Umemori, Shigeo Okabe, Tadashi Yamamoto Takanobu Nakazawa, Toshihiko Kuriu, Tohru Tezuka, Hisashi Umemori, Shigeo Okabe, Tadashi Yamamoto Takanobu Nakazawa, Toshihiko Kuriu, Tohru Tezuka, Hisashi Umemori, Shigeo Okabe, Tadashi Yamamoto Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP JOURNAL OF NEUROCHEMISTRY, 105, 4, 1384-1393 JOURNAL OF NEUROCHEMISTRY, 105, 4, 1384-1393 JOURNAL OF NEUROCHEMISTRY, 105, 4, 1384-1393 2008/05 英語 研究論文(学術雑誌) 公開
Yutaka Harita, Hidetake Kurihara, Hidetaka Kosako, Tohru Tezuka, Takashi Sekine, Takashi Igarashi, Seisuke Hattori Yutaka Harita, Hidetake Kurihara, Hidetaka Kosako, Tohru Tezuka, Takashi Sekine, Takashi Igarashi, Seisuke Hattori Yutaka Harita, Hidetake Kurihara, Hidetaka Kosako, Tohru Tezuka, Takashi Sekine, Takashi Igarashi, Seisuke Hattori Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2 Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2 Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2 JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 14, 9177-9186 JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 14, 9177-9186 JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 14, 9177-9186 2008/04 英語 研究論文(学術雑誌) 公開
Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Takahiro Masuda, Emika Toyomitsu, Tohru Tezuka, Tadashi Yamamoto, Kazuhide Inoue Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Takahiro Masuda, Emika Toyomitsu, Tohru Tezuka, Tadashi Yamamoto, Kazuhide Inoue Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Takahiro Masuda, Emika Toyomitsu, Tohru Tezuka, Tadashi Yamamoto, Kazuhide Inoue Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury GLIA, 56, 1, 50-58 GLIA, 56, 1, 50-58 GLIA, 56, 1, 50-58 2008/01 英語 研究論文(学術雑誌) 公開
Naosuke Hoshina, Tohru Tezuka, Kazumasa Yokoyama, Hiroko Kozuka-Hata, Masaaki Oyama, Tadashi Yamamoto Naosuke Hoshina, Tohru Tezuka, Kazumasa Yokoyama, Hiroko Kozuka-Hata, Masaaki Oyama, Tadashi Yamamoto Naosuke Hoshina, Tohru Tezuka, Kazumasa Yokoyama, Hiroko Kozuka-Hata, Masaaki Oyama, Tadashi Yamamoto Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth GENES TO CELLS, 12, 11, 1245-1254 GENES TO CELLS, 12, 11, 1245-1254 GENES TO CELLS, 12, 11, 1245-1254 2007/11 英語 研究論文(学術雑誌) 公開
Takeshi Inukai, Kanako Uno, Kikuyo Taniguchi, Kumiko Goi, Toru Tezuka, Atsushi Nemoto, Kazuya Takahashi, Hiroki Sato, Koshi Akahane, Kinuko Hirose, Hiroko Honna, Keiko Kagami, Asako Hiraoka, Misae Tanihiro, Shinpei Nakazawa, Kanji Sugita Takeshi Inukai, Kanako Uno, Kikuyo Taniguchi, Kumiko Goi, Toru Tezuka, Atsushi Nemoto, Kazuya Takahashi, Hiroki Sato, Koshi Akahane, Kinuko Hirose, Hiroko Honna, Keiko Kagami, Asako Hiraoka, Misae Tanihiro, Shinpei Nakazawa, Kanji Sugita Takeshi Inukai, Kanako Uno, Kikuyo Taniguchi, Kumiko Goi, Toru Tezuka, Atsushi Nemoto, Kazuya Takahashi, Hiroki Sato, Koshi Akahane, Kinuko Hirose, Hiroko Honna, Keiko Kagami, Asako Hiraoka, Misae Tanihiro, Shinpei Nakazawa, Kanji Sugita Monitoring neutrophil engraftment in allogeneic stem cell transplantation by flow cytometric analysis of neutrophil-specific antigens NA1 and NA2 Monitoring neutrophil engraftment in allogeneic stem cell transplantation by flow cytometric analysis of neutrophil-specific antigens NA1 and NA2 Monitoring neutrophil engraftment in allogeneic stem cell transplantation by flow cytometric analysis of neutrophil-specific antigens NA1 and NA2 BRITISH JOURNAL OF HAEMATOLOGY, 139, 2, 280-283 BRITISH JOURNAL OF HAEMATOLOGY, 139, 2, 280-283 BRITISH JOURNAL OF HAEMATOLOGY, 139, 2, 280-283 2007/10 英語 研究論文(学術雑誌) 公開
Shin-ichiro Kina, Tohru Tezuka, Shinji Kusakawa, Yasushi Kishimoto, Sho Kakizawa, Koichi Hashimoto, Miho Ohsugi, Yuji Kiyama, Reiko Horai, Katsuko Sudo, Shigeru Kakuta, Yoichiro Iwakura, Masamitsu Iino, Masanobu Kano, Toshiya Manabe, Tadashi Yamamoto Shin-ichiro Kina, Tohru Tezuka, Shinji Kusakawa, Yasushi Kishimoto, Sho Kakizawa, Koichi Hashimoto, Miho Ohsugi, Yuji Kiyama, Reiko Horai, Katsuko Sudo, Shigeru Kakuta, Yoichiro Iwakura, Masamitsu Iino, Masanobu Kano, Toshiya Manabe, Tadashi Yamamoto Shin-ichiro Kina, Tohru Tezuka, Shinji Kusakawa, Yasushi Kishimoto, Sho Kakizawa, Koichi Hashimoto, Miho Ohsugi, Yuji Kiyama, Reiko Horai, Katsuko Sudo, Shigeru Kakuta, Yoichiro Iwakura, Masamitsu Iino, Masanobu Kano, Toshiya Manabe, Tadashi Yamamoto Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression EUROPEAN JOURNAL OF NEUROSCIENCE, 26, 8, 2269-2278 EUROPEAN JOURNAL OF NEUROSCIENCE, 26, 8, 2269-2278 EUROPEAN JOURNAL OF NEUROSCIENCE, 26, 8, 2269-2278 2007/10 英語 研究論文(学術雑誌) 公開
Mina Delawary, Takanobu Nakazawa, Tohru Tezuka, Mariko Sawa, Yuichi Iino, Tadaomi Takenawa, Tadashi Yamamoto Mina Delawary, Takanobu Nakazawa, Tohru Tezuka, Mariko Sawa, Yuichi Iino, Tadaomi Takenawa, Tadashi Yamamoto Mina Delawary, Takanobu Nakazawa, Tohru Tezuka, Mariko Sawa, Yuichi Iino, Tadaomi Takenawa, Tadashi Yamamoto Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 357, 2, 377-382 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 357, 2, 377-382 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 357, 2, 377-382 2007/06 英語 研究論文(学術雑誌) 公開
Yoshiaki Kise, Kei Takenaka, Tohru Tezuka, Tadashi Yamamoto, Hiroaki Miki Yoshiaki Kise, Kei Takenaka, Tohru Tezuka, Tadashi Yamamoto, Hiroaki Miki Yoshiaki Kise, Kei Takenaka, Tohru Tezuka, Tadashi Yamamoto, Hiroaki Miki Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 351, 1, 78-84 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 351, 1, 78-84 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 351, 1, 78-84 2006/12 英語 研究論文(学術雑誌) 公開
Seiji Kawa, Chizuru Ito, Yoshiro Toyama, Mamiko Maekawa, Tohru Tezuka, Takahisa Nakamura, Takanobu Nakazawa, Kazumasa Yokoyama, Nobuaki Yoshida, Kiyotaka Toshimori, Tadashi Yamamoto Seiji Kawa, Chizuru Ito, Yoshiro Toyama, Mamiko Maekawa, Tohru Tezuka, Takahisa Nakamura, Takanobu Nakazawa, Kazumasa Yokoyama, Nobuaki Yoshida, Kiyotaka Toshimori, Tadashi Yamamoto Seiji Kawa, Chizuru Ito, Yoshiro Toyama, Mamiko Maekawa, Tohru Tezuka, Takahisa Nakamura, Takanobu Nakazawa, Kazumasa Yokoyama, Nobuaki Yoshida, Kiyotaka Toshimori, Tadashi Yamamoto Azoospermia in mice with targeted disruption of the Brek/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) gene Azoospermia in mice with targeted disruption of the Brek/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) gene Azoospermia in mice with targeted disruption of the Brek/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) gene PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103, 51, 19344-19349 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103, 51, 19344-19349 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103, 51, 19344-19349 2006/12 英語 研究論文(学術雑誌) 公開
Kazumasa Yokoyama, Tohru Tezuka, Naosuke Hoshina, Takanobu Nakazawa, Tadashi Yamamoto Kazumasa Yokoyama, Tohru Tezuka, Naosuke Hoshina, Takanobu Nakazawa, Tadashi Yamamoto Kazumasa Yokoyama, Tohru Tezuka, Naosuke Hoshina, Takanobu Nakazawa, Tadashi Yamamoto Phosphorylation at Tyr-694 of Nogo-A by Src-family kinases Phosphorylation at Tyr-694 of Nogo-A by Src-family kinases Phosphorylation at Tyr-694 of Nogo-A by Src-family kinases BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 349, 4, 1401-1405 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 349, 4, 1401-1405 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 349, 4, 1401-1405 2006/11 英語 研究論文(学術雑誌) 公開
Hui Liu, Takanobu Nakazawa, Tohru Tezuka, Tadashi Yamamoto Hui Liu, Takanobu Nakazawa, Tohru Tezuka, Tadashi Yamamoto Hui Liu, Takanobu Nakazawa, Tohru Tezuka, Tadashi Yamamoto Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 33, 23611-23619 JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 33, 23611-23619 JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 33, 23611-23619 2006/08 英語 研究論文(学術雑誌) 公開
Takanobu Nakazawa, Shoji Komai, Ayako M. Watabe, Yuji Kiyama, Masahiro Fukaya, Fumiko Arima-Yoshida, Reiko Horai, Katsuko Sudo, Kazumi Ebine, Mina Delawary, June Goto, Hisashi Umemori, Tohru Tezuka, Yoichiro Iwakura, Masahiko Watanabe, Tadashi Yamamoto, Toshiya Manabe Takanobu Nakazawa, Shoji Komai, Ayako M. Watabe, Yuji Kiyama, Masahiro Fukaya, Fumiko Arima-Yoshida, Reiko Horai, Katsuko Sudo, Kazumi Ebine, Mina Delawary, June Goto, Hisashi Umemori, Tohru Tezuka, Yoichiro Iwakura, Masahiko Watanabe, Tadashi Yamamoto, Toshiya Manabe Takanobu Nakazawa, Shoji Komai, Ayako M. Watabe, Yuji Kiyama, Masahiro Fukaya, Fumiko Arima-Yoshida, Reiko Horai, Katsuko Sudo, Kazumi Ebine, Mina Delawary, June Goto, Hisashi Umemori, Tohru Tezuka, Yoichiro Iwakura, Masahiko Watanabe, Tadashi Yamamoto, Toshiya Manabe NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity EMBO JOURNAL, 25, 12, 2867-2877 EMBO JOURNAL, 25, 12, 2867-2877 EMBO JOURNAL, 25, 12, 2867-2877 2006/06 英語 研究論文(学術雑誌) 公開
K Nishida, S Yamasaki, Y Ito, K Kabu, K Hattori, T Tezuka, H Nishizumi, D Kitamura, R Goitsuka, RS Geha, T Yamamoto, T Yagi, T Hirano K Nishida, S Yamasaki, Y Ito, K Kabu, K Hattori, T Tezuka, H Nishizumi, D Kitamura, R Goitsuka, RS Geha, T Yamamoto, T Yagi, T Hirano K Nishida, S Yamasaki, Y Ito, K Kabu, K Hattori, T Tezuka, H Nishizumi, D Kitamura, R Goitsuka, RS Geha, T Yamamoto, T Yagi, T Hirano Fc epsilon RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane Fc epsilon RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane Fc epsilon RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane JOURNAL OF CELL BIOLOGY, 170, 1, 115-126 JOURNAL OF CELL BIOLOGY, 170, 1, 115-126 JOURNAL OF CELL BIOLOGY, 170, 1, 115-126 2005/07 英語 研究論文(学術雑誌) 公開
S Suetsugu, T Tezuka, T Morimura, M Hattori, K Mikoshiba, T Yamamoto, T Takenawa S Suetsugu, T Tezuka, T Morimura, M Hattori, K Mikoshiba, T Yamamoto, T Takenawa S Suetsugu, T Tezuka, T Morimura, M Hattori, K Mikoshiba, T Yamamoto, T Takenawa Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1 Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1 Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1 BIOCHEMICAL JOURNAL, 384, Pt 1, 1-8 BIOCHEMICAL JOURNAL, 384, Pt 1, 1-8 BIOCHEMICAL JOURNAL, 384, Pt 1, 1-8 2004/11 英語 研究論文(学術雑誌) 公開
Inukai T, Sugita K, Goi K, Akahane K, Hirose K, Nemoto A, Takahashi K, Sato H, Uno K, Furuichi Y, Nakamura M, Miyamoto N, Yamakawa N, Shiraishi K, Kojika S, Tezuka T, Iijima K, Nakazawa S Inukai T, Sugita K, Goi K, Akahane K, Hirose K, Nemoto A, Takahashi K, Sato H, Uno K, Furuichi Y, Nakamura M, Miyamoto N, Yamakawa N, Shiraishi K, Kojika S, Tezuka T, Iijima K, Nakazawa S Inukai T, Sugita K, Goi K, Akahane K, Hirose K, Nemoto A, Takahashi K, Sato H, Uno K, Furuichi Y, Nakamura M, Miyamoto N, Yamakawa N, Shiraishi K, Kojika S, Tezuka T, Iijima K, Nakazawa S [Prevention of hepatic veno-occlusive disease by a combination of heparin and prostaglandin E1 in children undergoing hematopoietic stem cell transplantation] [Prevention of hepatic veno-occlusive disease by a combination of heparin and prostaglandin E1 in children undergoing hematopoietic stem cell transplantation] [Prevention of hepatic veno-occlusive disease by a combination of heparin and prostaglandin E1 in children undergoing hematopoietic stem cell transplantation] [Rinsho ketsueki] The Japanese journal of clinical hematology, 45, 4, 297-303 [Rinsho ketsueki] The Japanese journal of clinical hematology, 45, 4, 297-303 [Rinsho ketsueki] The Japanese journal of clinical hematology, 45, 4, 297-303 2004/04 公開
Inukai T, Sugita K, Goto M, Nakamura M, Tezuka T, Goi K, Iijima K, Ishihara T, Kagami K, Noji H, Shichishima T, Nakazawa S Inukai T, Sugita K, Goto M, Nakamura M, Tezuka T, Goi K, Iijima K, Ishihara T, Kagami K, Noji H, Shichishima T, Nakazawa S Inukai T, Sugita K, Goto M, Nakamura M, Tezuka T, Goi K, Iijima K, Ishihara T, Kagami K, Noji H, Shichishima T, Nakazawa S [Spontaneous recovery from pancytopenia in a young female patient with paroxysmal nocturnal hemoglobinuria(PNH): changes in the GPI-anchor expression on peripheral blood cells] [Spontaneous recovery from pancytopenia in a young female patient with paroxysmal nocturnal hemoglobinuria(PNH): changes in the GPI-anchor expression on peripheral blood cells] [Spontaneous recovery from pancytopenia in a young female patient with paroxysmal nocturnal hemoglobinuria(PNH): changes in the GPI-anchor expression on peripheral blood cells] [Rinsho ketsueki] The Japanese journal of clinical hematology, 45, 3, 238-242 [Rinsho ketsueki] The Japanese journal of clinical hematology, 45, 3, 238-242 [Rinsho ketsueki] The Japanese journal of clinical hematology, 45, 3, 238-242 2004/03 公開
M Kim, T Tezuka, K Tanaka, T Yamamoto M Kim, T Tezuka, K Tanaka, T Yamamoto M Kim, T Tezuka, K Tanaka, T Yamamoto Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation ONCOGENE, 23, 9, 1645-1655 ONCOGENE, 23, 9, 1645-1655 ONCOGENE, 23, 9, 1645-1655 2004/03 英語 研究論文(学術雑誌) 公開
Kawa S, Fujimoto J, Tezuka T, Nakazawa T, Yamamoto T Kawa S, Fujimoto J, Tezuka T, Nakazawa T, Yamamoto T Kawa S, Fujimoto J, Tezuka T, Nakazawa T, Yamamoto T Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling. Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling. Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling. Genes to cells : devoted to molecular & cellular mechanisms, 9, 3, 219-232 Genes to cells : devoted to molecular & cellular mechanisms, 9, 3, 219-232 Genes to cells : devoted to molecular & cellular mechanisms, 9, 3, 219-232 2004/03 公開
J Goto, T Tezuka, T Nakazawa, N Tsukamoto, T Nakamura, R Ajima, K Yokoyama, T Ohta, M Ohki, T Yamamoto J Goto, T Tezuka, T Nakazawa, N Tsukamoto, T Nakamura, R Ajima, K Yokoyama, T Ohta, M Ohki, T Yamamoto J Goto, T Tezuka, T Nakazawa, N Tsukamoto, T Nakamura, R Ajima, K Yokoyama, T Ohta, M Ohki, T Yamamoto Altered gene expression in the adult brain of fyn-deficient mice Altered gene expression in the adult brain of fyn-deficient mice Altered gene expression in the adult brain of fyn-deficient mice CELLULAR AND MOLECULAR NEUROBIOLOGY, 24, 1, 149-159 CELLULAR AND MOLECULAR NEUROBIOLOGY, 24, 1, 149-159 CELLULAR AND MOLECULAR NEUROBIOLOGY, 24, 1, 149-159 2004/02 英語 研究論文(学術雑誌) 公開
N Mizobe, K Sugita, T Tezuka, M Sakamoto, Y Fukada, K Hoshi, S Nakazawa N Mizobe, K Sugita, T Tezuka, M Sakamoto, Y Fukada, K Hoshi, S Nakazawa N Mizobe, K Sugita, T Tezuka, M Sakamoto, Y Fukada, K Hoshi, S Nakazawa Transient decrease in the CD45RA expression on T lymphocytes in neonates with fetal distress Transient decrease in the CD45RA expression on T lymphocytes in neonates with fetal distress Transient decrease in the CD45RA expression on T lymphocytes in neonates with fetal distress BIOLOGY OF THE NEONATE, 85, 1, 61-67 BIOLOGY OF THE NEONATE, 85, 1, 61-67 BIOLOGY OF THE NEONATE, 85, 1, 61-67 2004 英語 研究論文(学術雑誌) 公開
Inoue Y, Tezuka T, Shinohara T, Mitsunaga A, Ooi I, Takasaki K Inoue Y, Tezuka T, Shinohara T, Mitsunaga A, Ooi I, Takasaki K Inoue Y, Tezuka T, Shinohara T, Mitsunaga A, Ooi I, Takasaki K [QOL in elderly patients with colorectal cancer] [QOL in elderly patients with colorectal cancer] [QOL in elderly patients with colorectal cancer] Nippon rinsho. Japanese journal of clinical medicine, 61 Suppl 7, 540-544 Nippon rinsho. Japanese journal of clinical medicine, 61 Suppl 7, 540-544 Nippon rinsho. Japanese journal of clinical medicine, 61 Suppl 7, 540-544 2003/09 公開
T Nakazawa, AM Watabe, T Tezuka, Y Yoshida, K Yokoyama, H Umemori, A Inoue, S Okabe, T Manabe, T Yamamoto T Nakazawa, AM Watabe, T Tezuka, Y Yoshida, K Yokoyama, H Umemori, A Inoue, S Okabe, T Manabe, T Yamamoto T Nakazawa, AM Watabe, T Tezuka, Y Yoshida, K Yokoyama, H Umemori, A Inoue, S Okabe, T Manabe, T Yamamoto p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-D-aspartate receptor signaling p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-D-aspartate receptor signaling p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-D-aspartate receptor signaling MOLECULAR BIOLOGY OF THE CELL, 14, 7, 2921-2934 MOLECULAR BIOLOGY OF THE CELL, 14, 7, 2921-2934 MOLECULAR BIOLOGY OF THE CELL, 14, 7, 2921-2934 2003/07 英語 研究論文(学術雑誌) 公開
Yasuo Watanabe, Tao Song, Katsuyoshi Sugimoto, Mariko Horii, Nobukazu Araki, Hiroshi Tokumitsu, Tohru Tezuka, Tadashi Yamamoto, Masaaki Tokuda Yasuo Watanabe, Tao Song, Katsuyoshi Sugimoto, Mariko Horii, Nobukazu Araki, Hiroshi Tokumitsu, Tohru Tezuka, Tadashi Yamamoto, Masaaki Tokuda Yasuo Watanabe, Tao Song, Katsuyoshi Sugimoto, Mariko Horii, Nobukazu Araki, Hiroshi Tokumitsu, Tohru Tezuka, Tadashi Yamamoto, Masaaki Tokuda Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase. Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase. Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase. The Biochemical journal, 372, Pt 2, 465-71 The Biochemical journal, 372, Pt 2, 465-71 The Biochemical journal, 372, Pt 2, 465-71 2003/06/01 英語 公開
S Taniguchi, H Liu, T Nakazawa, K Yokoyama, T Tezuka, T Yamamoto S Taniguchi, H Liu, T Nakazawa, K Yokoyama, T Tezuka, T Yamamoto S Taniguchi, H Liu, T Nakazawa, K Yokoyama, T Tezuka, T Yamamoto p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 306, 1, 151-155 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 306, 1, 151-155 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 306, 1, 151-155 2003/06 英語 研究論文(学術雑誌) 公開
S Suetsugu, M Hattori, H Miki, T Tezuka, T Yamamoto, K Mikoshiba, T Takenawa S Suetsugu, M Hattori, H Miki, T Tezuka, T Yamamoto, K Mikoshiba, T Takenawa S Suetsugu, M Hattori, H Miki, T Tezuka, T Yamamoto, K Mikoshiba, T Takenawa Sustained activation of N-WASP through phosphorylation is essential for neurite extension Sustained activation of N-WASP through phosphorylation is essential for neurite extension Sustained activation of N-WASP through phosphorylation is essential for neurite extension DEVELOPMENTAL CELL, 3, 5, 645-658 DEVELOPMENTAL CELL, 3, 5, 645-658 DEVELOPMENTAL CELL, 3, 5, 645-658 2002/11 英語 研究論文(学術雑誌) 公開
Nakazawa T, Tezuka T, Yamamoto T Nakazawa T, Tezuka T, Yamamoto T Nakazawa T, Tezuka T, Yamamoto T [Regulation of NMDA receptor function by Fyn-mediated tyrosine phosphorylation]. [Regulation of NMDA receptor function by Fyn-mediated tyrosine phosphorylation]. [Regulation of NMDA receptor function by Fyn-mediated tyrosine phosphorylation]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 22, 5, 165-167 Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 22, 5, 165-167 Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 22, 5, 165-167 2002/10 公開
T Yasuda, T Tezuka, A Maeda, T Inazu, Y Yamanashi, H Gu, T Kurosaki, T Yamamoto T Yasuda, T Tezuka, A Maeda, T Inazu, Y Yamanashi, H Gu, T Kurosaki, T Yamamoto T Yasuda, T Tezuka, A Maeda, T Inazu, Y Yamanashi, H Gu, T Kurosaki, T Yamamoto Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma 2 in B cells Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma 2 in B cells Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma 2 in B cells JOURNAL OF EXPERIMENTAL MEDICINE, 196, 1, 51-63 JOURNAL OF EXPERIMENTAL MEDICINE, 196, 1, 51-63 JOURNAL OF EXPERIMENTAL MEDICINE, 196, 1, 51-63 2002/07 英語 研究論文(学術雑誌) 公開
D Kitagawa, S Tanemura, S Ohata, N Shimizu, J Seo, G Nishitai, T Watanabe, K Nakagawa, H Kishimoto, T Wada, T Tezuka, T Yamamoto, H Nishina, T Katada D Kitagawa, S Tanemura, S Ohata, N Shimizu, J Seo, G Nishitai, T Watanabe, K Nakagawa, H Kishimoto, T Wada, T Tezuka, T Yamamoto, H Nishina, T Katada D Kitagawa, S Tanemura, S Ohata, N Shimizu, J Seo, G Nishitai, T Watanabe, K Nakagawa, H Kishimoto, T Wada, T Tezuka, T Yamamoto, H Nishina, T Katada Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation - Its implication in an anti-apoptotic function Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation - Its implication in an anti-apoptotic function Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation - Its implication in an anti-apoptotic function JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 1, 366-371 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 1, 366-371 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 1, 366-371 2002/01 英語 研究論文(学術雑誌) 公開
K Yokoyama, Su, I, T Tezuka, T Yasuda, K Mikoshiba, A Tarakhovsky, T Yamamoto K Yokoyama, Su, I, T Tezuka, T Yasuda, K Mikoshiba, A Tarakhovsky, T Yamamoto K Yokoyama, Su, I, T Tezuka, T Yasuda, K Mikoshiba, A Tarakhovsky, T Yamamoto BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP3 receptor BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP3 receptor BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP3 receptor EMBO JOURNAL, 21, 1-2, 83-92 EMBO JOURNAL, 21, 1-2, 83-92 EMBO JOURNAL, 21, 1-2, 83-92 2002/01 英語 研究論文(学術雑誌) 公開

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著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
PSD-95 Promotes Fyn-Mediated Tyrosine Phosphorylation of the N-Methyl D-Aspartate Receptor Subunit NR2A PSD-95 Promotes Fyn-Mediated Tyrosine Phosphorylation of the N-Methyl D-Aspartate Receptor Subunit NR2A Proc Natl. Acad. Sci USA, 96(2), 435-440 Proc Natl. Acad. Sci USA, 96(2), 435-440 , 96(2), 435-440 1999 公開
PSD-95 Promotes Fyn-Mediated Tyrosine Phosphorylation of the N-Methyl D-Aspartate Receptor Subunit NR2A PSD-95 Promotes Fyn-Mediated Tyrosine Phosphorylation of the N-Methyl D-Aspartate Receptor Subunit NR2A PSD-95 Promotes Fyn-Mediated Tyrosine Phosphorylation of the N-Methyl D-Aspartate Receptor Subunit NR2A Proc Natl. Acad. Sci USA, 96(2), 435-440 Proc Natl. Acad. Sci USA, 96(2), 435-440 Proc Natl. Acad. Sci USA, 96(2), 435-440 1999 公開
Physical and Functional Association of the Cbl Protoonco Gene Product with an Src-Family Protein Tyrosire Kinase, p53/56lyn, in the B Cell Antigen Receptor-Mediated Signaling Physical and Functional Association of the Cbl Protoonco Gene Product with an Src-Family Protein Tyrosire Kinase, p53/56lyn, in the B Cell Antigen Receptor-Mediated Signaling Journal of Experimental Medicine, 183(2), 675-680 Journal of Experimental Medicine, 183(2), 675-680 , 183(2), 675-680 1996 公開
Physical and Functional Association of the Cbl Protoonco Gene Product with an Src-Family Protein Tyrosire Kinase, p53/56lyn, in the B Cell Antigen Receptor-Mediated Signaling Physical and Functional Association of the Cbl Protoonco Gene Product with an Src-Family Protein Tyrosire Kinase, p53/56lyn, in the B Cell Antigen Receptor-Mediated Signaling Physical and Functional Association of the Cbl Protoonco Gene Product with an Src-Family Protein Tyrosire Kinase, p53/56lyn, in the B Cell Antigen Receptor-Mediated Signaling Journal of Experimental Medicine, 183(2), 675-680 Journal of Experimental Medicine, 183(2), 675-680 Journal of Experimental Medicine, 183(2), 675-680 1996 公開
タイトル言語:
外部資金:競争的資金 (科学研究費補助金)
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
基盤研究(B) 代表 もやもや病や脳梗塞の遺伝性リスク因子の機能解析 2020/04/01〜2023/03/31
新学術領域研究(研究領域提案型) 分担 炎症細胞社会の中でのRNF213変異によるかく乱と血管閉塞性病変形成の解明 2018/04/01〜2021/03/31
基盤研究(B) 代表 もやもや病や脳梗塞の遺伝性リスク因子の機能解析 (2020年度分) 2020/04/01〜2021/03/31
外部資金:競争的資金 (科学研究費補助金以外)
制度名 代表者名 研究課題(日本語) 研究課題(英語) 期間
日本医療研究開発機構 峰晴 陽平 ゲノム編集疾患iPS細胞を用いた閉塞性血管疾患のモデル樹立と病態解明 2021/05/26〜2024/03/31
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
ILASセミナー ILAS Seminar 前期集中 全学共通科目 2019/04〜2020/03