福島 祐二

最終更新日時: 2021/06/23 10:02:53

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氏名(漢字/フリガナ/アルファベット表記)
福島 祐二/フクシマ ユウジ/Fukushima, Yuji
所属部署・職名(部局/所属/講座等/職名)
医学研究科/免疫老化学講座(産学共同)/特定助教
所属学会(国内)
学会名(日本語) 学会名(英語)
日本免疫学会 Japanese Society for Immunology
日本分子生物学会 The Molecular Biology Society of Japan
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士(農学) 広島大学
博士(農学) 広島大学
職歴
期間 組織名(日本語) 組織名(英語) 職名(日本語) 職名(英語)
2010/04/01〜2011/03/31 広島大学生物圏科学研究科 Graduate School of Biosphere Science, Hiroshima University 特任助教 Assistant Professor
2011/04/01〜2017/03/31 京都大学医学研究科 Graduate School of Medicine, Kyoto University 研究員 Researcher
2018/04/01〜 京都大学医学研究科 Graduate School of Medicine, Kyoto University 特定助教 Assistant Professor
researchmap URL
https://researchmap.jp/7000010589
研究テーマ
(日本語)
免疫老化を制御する新規分子メカニズムの解明
(英語)
We aim to understand molecular mechanisms of immunosenescence that underlie the incidence of age-related diseases, with a particular focus on senescence-associated T (SA-T) cells and a possible regulator CD153.
研究概要
(日本語)
加齢に伴う免疫システムの変化(免疫老化)は老化関連疾患の発生頻度を増加させる要因のひとつであるが、そのメカニズムは不明である。私たちはこれまで、免疫老化に深く関与する老化関連T(SA-T)細胞を同定し、この細胞がSLEをはじめとする様々な疾患の発症・増悪に関与することを示してきた。現在はさらに、SA-T細胞が発現するCD153分子に着目して免疫老化メカニズムの解明と老化関連疾患の治療薬開発に貢献することを目指している。
(英語)
Immune system aging (immunosenescence) underlie the development of age-related diseases including inflammatory diseases, metabolic diseases, autoimmune diseases and cancer, but the mechanism is not fully understood. We previously identified a unique CD4 T cell subpopulation that plays a profound role in immunesenescence and termed them senescence-associated T (SA-T) cells. SA-T cells express particular cell surface proteins (PD-1, CD153) and produce inflammatory cytokines (OPN), which potentially contribute to the pathogenesis. We aim to clarify the molecular mechanism of SA-T cell regulation using genetic/biochemical approaches, in vitro cell culture systems, and genetically modified mice to develop novel therapeutic drugs, with a particular focus on a role of CD153.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
免疫学 Immunology
分子生物学 Molocular biology
老化 Aging
シグナル伝達 Signal transduction
病態制御 Disease control
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Fukushima Y, Minato N, Hattori M Fukushima Y, Minato N, Hattori M Fukushima Y, Minato N, Hattori M The impact of senescence-associated T cells on immunosenescence and age-related disorders The impact of senescence-associated T cells on immunosenescence and age-related disorders The impact of senescence-associated T cells on immunosenescence and age-related disorders Inflammation and regeneration, 38, 24 Inflammation and regeneration, 38, 24 Inflammation and regeneration, 38, 24 2018 英語 研究論文(学術雑誌) 公開
Koyu Ito, Akira Nakajima, Yuji Fukushima, Keiichiro Suzuki, Keiko Sakamoto, Yoko Hamazaki, Kouetsu Ogasawara, Nagahiro Minato, Masakazu Hattori Koyu Ito, Akira Nakajima, Yuji Fukushima, Keiichiro Suzuki, Keiko Sakamoto, Yoko Hamazaki, Kouetsu Ogasawara, Nagahiro Minato, Masakazu Hattori Koyu Ito, Akira Nakajima, Yuji Fukushima, Keiichiro Suzuki, Keiko Sakamoto, Yoko Hamazaki, Kouetsu Ogasawara, Nagahiro Minato, Masakazu Hattori The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine. The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine. The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine. PloS one, 12, 3, e0173629 PloS one, 12, 3, e0173629 PloS one, 12, 3, e0173629 2017 英語 研究論文(学術雑誌) 公開
Keiko Sakamoto, Yuji Fukushima, Koyu Ito, Michiyuki Matsuda, Shigekazu Nagata, Nagahiro Minato, Masakazu Hattori Keiko Sakamoto, Yuji Fukushima, Koyu Ito, Michiyuki Matsuda, Shigekazu Nagata, Nagahiro Minato, Masakazu Hattori Keiko Sakamoto, Yuji Fukushima, Koyu Ito, Michiyuki Matsuda, Shigekazu Nagata, Nagahiro Minato, Masakazu Hattori Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice. Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice. Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice. Journal of immunology (Baltimore, Md. : 1950), 197, 6, 2177-86 Journal of immunology (Baltimore, Md. : 1950), 197, 6, 2177-86 Journal of immunology (Baltimore, Md. : 1950), 197, 6, 2177-86 2016/09/15 英語 研究論文(学術雑誌) 公開
Suhail Tahir, Yuji Fukushima, Keiko Sakamoto, Kyosuke Sato, Harumi Fujita, Joe Inoue, Toshimitsu Uede, Yoko Hamazaki, Masakazu Hattori, Nagahiro Minato Suhail Tahir, Yuji Fukushima, Keiko Sakamoto, Kyosuke Sato, Harumi Fujita, Joe Inoue, Toshimitsu Uede, Yoko Hamazaki, Masakazu Hattori, Nagahiro Minato Suhail Tahir, Yuji Fukushima, Keiko Sakamoto, Kyosuke Sato, Harumi Fujita, Joe Inoue, Toshimitsu Uede, Yoko Hamazaki, Masakazu Hattori, Nagahiro Minato A CD153(+)CD4(+) T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production A CD153(+)CD4(+) T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production A CD153(+)CD4(+) T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production JOURNAL OF IMMUNOLOGY, 194, 12, 5725-5735 JOURNAL OF IMMUNOLOGY, 194, 12, 5725-5735 JOURNAL OF IMMUNOLOGY, 194, 12, 5725-5735 2015/06 英語 研究論文(学術雑誌) 公開
Yuji Fukushima, Tomohiro Miyai, Manami Kumagae, Hiroyuki Horiuchi, Shuichi Furusawa Yuji Fukushima, Tomohiro Miyai, Manami Kumagae, Hiroyuki Horiuchi, Shuichi Furusawa Yuji Fukushima, Tomohiro Miyai, Manami Kumagae, Hiroyuki Horiuchi, Shuichi Furusawa Molecular cloning of chicken interleukin-5 receptor alpha-chain and analysis of its binding specificity Molecular cloning of chicken interleukin-5 receptor alpha-chain and analysis of its binding specificity Molecular cloning of chicken interleukin-5 receptor alpha-chain and analysis of its binding specificity DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 37, 3-4, 354-362 DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 37, 3-4, 354-362 DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 37, 3-4, 354-362 2012/07 英語 研究論文(学術雑誌) 公開
Yuji Fukushima, Masaharu Sato, Haruo Matsuda, Shuichi Furusawa, Hiroyuki Horiuchi Yuji Fukushima, Masaharu Sato, Haruo Matsuda, Shuichi Furusawa, Hiroyuki Horiuchi Yuji Fukushima, Masaharu Sato, Haruo Matsuda, Shuichi Furusawa, Hiroyuki Horiuchi Construction of an Insertion Vector for Gene Targeting of Chicken Lens-specific Gene Construction of an Insertion Vector for Gene Targeting of Chicken Lens-specific Gene Construction of an Insertion Vector for Gene Targeting of Chicken Lens-specific Gene JOURNAL OF POULTRY SCIENCE, 47, 2, 144-148 JOURNAL OF POULTRY SCIENCE, 47, 2, 144-148 JOURNAL OF POULTRY SCIENCE, 47, 2, 144-148 2010/04 英語 研究論文(学術雑誌) 公開
Mohamed Fahmy Abou Elazab, Yuji Fukushima, Yukihiro Fujita, Hiroyuki Horiuchi, Haruo Matsuda, Shuichi Furusawa Mohamed Fahmy Abou Elazab, Yuji Fukushima, Yukihiro Fujita, Hiroyuki Horiuchi, Haruo Matsuda, Shuichi Furusawa Mohamed Fahmy Abou Elazab, Yuji Fukushima, Yukihiro Fujita, Hiroyuki Horiuchi, Haruo Matsuda, Shuichi Furusawa Induction of Immune Suppression in the Chick by an Optimal Dose of an Immunizing Antigen in the Presence of its Specific Maternal Antibody Induction of Immune Suppression in the Chick by an Optimal Dose of an Immunizing Antigen in the Presence of its Specific Maternal Antibody Induction of Immune Suppression in the Chick by an Optimal Dose of an Immunizing Antigen in the Presence of its Specific Maternal Antibody JOURNAL OF VETERINARY MEDICAL SCIENCE, 72, 3, 257-262 JOURNAL OF VETERINARY MEDICAL SCIENCE, 72, 3, 257-262 JOURNAL OF VETERINARY MEDICAL SCIENCE, 72, 3, 257-262 2010/03 英語 研究論文(学術雑誌) 公開
Mohamed Fahmy Abou Elazab, Yuji Fukushima, Hiroyuki Horiuchi, Haruo Matsuda, Shuichi Furusawa Mohamed Fahmy Abou Elazab, Yuji Fukushima, Hiroyuki Horiuchi, Haruo Matsuda, Shuichi Furusawa Mohamed Fahmy Abou Elazab, Yuji Fukushima, Hiroyuki Horiuchi, Haruo Matsuda, Shuichi Furusawa Prolonged Suppression of Chick Humoral Immune Response by Antigen Specific Maternal Antibody Prolonged Suppression of Chick Humoral Immune Response by Antigen Specific Maternal Antibody Prolonged Suppression of Chick Humoral Immune Response by Antigen Specific Maternal Antibody JOURNAL OF VETERINARY MEDICAL SCIENCE, 71, 4, 417-424 JOURNAL OF VETERINARY MEDICAL SCIENCE, 71, 4, 417-424 JOURNAL OF VETERINARY MEDICAL SCIENCE, 71, 4, 417-424 2009/04 英語 研究論文(学術雑誌) 公開
Miki Miyoshi, Hiroyuki Horiuchi, Yuji Fukushima, Haruo Matsuda, Shuichi Furusawaa Miki Miyoshi, Hiroyuki Horiuchi, Yuji Fukushima, Haruo Matsuda, Shuichi Furusawaa Miki Miyoshi, Hiroyuki Horiuchi, Yuji Fukushima, Haruo Matsuda, Shuichi Furusawaa Cloning of the chicken interleukin-13 receptor alpha 2 gene and production of a specific monoclonal antibody Cloning of the chicken interleukin-13 receptor alpha 2 gene and production of a specific monoclonal antibody Cloning of the chicken interleukin-13 receptor alpha 2 gene and production of a specific monoclonal antibody DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 31, 4, 394-406 DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 31, 4, 394-406 DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 31, 4, 394-406 2007 英語 研究論文(学術雑誌) 公開
タイトル言語:
講演・口頭発表等
タイトル タイトル(日本語) タイトル(英語) 会議名 会議名(日本語) 会議名(英語) 主催者 主催者(日本語) 主催者(英語) 発表年月日 記述言語 会議種別 公開
CD153-CD30 interaction is involved in immunosenescence of T cells and spontaneous germinal center reactions CD153-CD30 interaction is involved in immunosenescence of T cells and spontaneous germinal center reactions 日本免疫学会 日本免疫学会 2016/12 口頭発表(一般) 公開
タイトル言語:
外部資金:競争的資金 (科学研究費補助金)
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
基盤研究(B) 分担 老化関連T細胞誘導メカニズムの解明と人為的制御 2017/04/01〜2020/03/31