茂木 章

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氏名(漢字/フリガナ/アルファベット表記)
茂木 章/モテギ アキラ/Motegi, Akira
所属部署・職名(部局/所属/講座等/職名)
医学研究科/医学専攻遺伝医学講座放射線遺伝学/助教
学部兼担
部局 所属 講座等 職名
医学部
所属学会(国内)
学会名(日本語) 学会名(英語)
日本分子生物学会 The Molecular Biology Society of Japan
日本生化学会 The Japanese Biochemical Society
日本癌学会 The Japanese Cancer Association
日本放射線影響学会 The Japanese Radiation Research Society
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
博士(医学) 東京大学
出身大学院・研究科等
大学名(日本語) 大学名(英語) 研究科名(日本語) 研究科名(英語) 専攻名(日本語) 専攻名(英語) 修了区分
東京大学 大学院医学研究科博士課程病因・病理学専攻 修了
出身学校・専攻等
大学名(日本語) 大学名(英語) 学部名(日本語) 学部名(英語) 学科名(日本語) 学科名(英語) 卒業区分
群馬大学 医学部医学科 卒業
職歴
期間 組織名(日本語) 組織名(英語) 職名(日本語) 職名(英語)
2001〜 東京大学付属医科学研究所 特別研究員
2001〜 米国国立衛生研究所・国立癌研究所 客員研究員
2003〜 日本学術振興会 海外特別研究員 (NIH)
2003〜 米国国立衛生研究所・国立ヒトゲノム研究所 客員研究員
2006〜 米国国立衛生研究所・国立ヒトゲノム研究所 研究員
2007〜 京都大学大学院医学研究科 遺伝医学講座 放射線遺伝学分野 助教
researchmap URL
https://researchmap.jp/7000008668
研究テーマ
(日本語)
ゲノム維持機構の分子機序、発がんの分子機序、がんの精密医療の分子基盤
(英語)
Molecular mechanisms of genome maintenance, molecular carcinogenesis, and a molecular basis of cancer precision medicine
研究概要
(日本語)
細胞は様々なDNA損傷を修復し、正常なゲノムを維持するための多様な仕組みを備えている。これらの仕組みはがんなどの原因となる遺伝子変異を抑制するとともに、遺伝子変異を積極的に導入する。この諸刃の剣である「ゲノム維持機構」の分子機序を解明することで「発がんの分子機序」を理解し、さらに「がんの精密医療」を実現するための分子基盤の確立を目指している。
(英語)
Cells possess mechanisms that sense and respond to various types of DNA damage in the genome. Such mechanisms, collectively called DNA damage response (DDR), are not only the major barriers but also the mediators of pathogenic mutations. My research focuses on uncovering the molecular mechanisms of genome maintenance and thereby facilitating understanding of the molecular carcinogenesis steps and providing a basis for cancer precision medicine.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
ゲノム維持 genome maintenance
発がんの分子機序 molecular carcinogenesis
がんの精密医療 cancer precision medicine
タンパク質の翻訳後修飾 protein post-translational modifications
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Koji Nishimoto, Hiroyuki Niida, Chiharu Uchida, Tatsuya Ohhata, Kyoko Kitagawa, Akira Motegi, Takafumi Suda, Masatoshi Kitagawa Koji Nishimoto, Hiroyuki Niida, Chiharu Uchida, Tatsuya Ohhata, Kyoko Kitagawa, Akira Motegi, Takafumi Suda, Masatoshi Kitagawa Koji Nishimoto, Hiroyuki Niida, Chiharu Uchida, Tatsuya Ohhata, Kyoko Kitagawa, Akira Motegi, Takafumi Suda, Masatoshi Kitagawa HDAC3 Is Required for XPC Recruitment and Nucleotide Excision Repair of DNA Damage Induced by UV Irradiation. HDAC3 Is Required for XPC Recruitment and Nucleotide Excision Repair of DNA Damage Induced by UV Irradiation. HDAC3 Is Required for XPC Recruitment and Nucleotide Excision Repair of DNA Damage Induced by UV Irradiation. Molecular cancer research : MCR Molecular cancer research : MCR Molecular cancer research : MCR 2020/06/11 英語 研究論文(学術雑誌) 公開
Motegi A, Masutani M, Yoshioka KI, Bessho T Motegi A, Masutani M, Yoshioka KI, Bessho T Motegi A, Masutani M, Yoshioka KI, Bessho T Aberrations in DNA repair pathways in cancer and therapeutic significances. Aberrations in DNA repair pathways in cancer and therapeutic significances. Aberrations in DNA repair pathways in cancer and therapeutic significances. Seminars in cancer biology Seminars in cancer biology Seminars in cancer biology 2019/03 公開
Niida H, Matsunuma R, Horiguchi R, Uchida C, Nakazawa Y, Motegi A, Nishimoto K, Sakai S, Ohhata T, Kitagawa K, Moriwaki S, Nishitani H, Ui A, Ogi T, Kitagawa M Niida H, Matsunuma R, Horiguchi R, Uchida C, Nakazawa Y, Motegi A, Nishimoto K, Sakai S, Ohhata T, Kitagawa K, Moriwaki S, Nishitani H, Ui A, Ogi T, Kitagawa M Niida H, Matsunuma R, Horiguchi R, Uchida C, Nakazawa Y, Motegi A, Nishimoto K, Sakai S, Ohhata T, Kitagawa K, Moriwaki S, Nishitani H, Ui A, Ogi T, Kitagawa M Erratum: Author Correction: Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair (Nature communications (2017) 8 (16102)) Erratum: Author Correction: Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair (Nature communications (2017) 8 (16102)) Erratum: Author Correction: Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair (Nature communications (2017) 8 (16102)) Nature communications, 9, 16214 Nature communications, 9, 16214 Nature communications, 9, 16214 2018 公開
Ayako L. Mochizuki, Ami Katanaya, Eri Hayashi, Mihoko Hosokawa, Emiko Moribe, Akira Motegi, Masamichi Ishiai, Minoru Takata, Gen Kondoh, Hitomi Watanabe, Norio Nakatsuji, Shinichiro Chuma Ayako L. Mochizuki, Ami Katanaya, Eri Hayashi, Mihoko Hosokawa, Emiko Moribe, Akira Motegi, Masamichi Ishiai, Minoru Takata, Gen Kondoh, Hitomi Watanabe, Norio Nakatsuji, Shinichiro Chuma Ayako L. Mochizuki, Ami Katanaya, Eri Hayashi, Mihoko Hosokawa, Emiko Moribe, Akira Motegi, Masamichi Ishiai, Minoru Takata, Gen Kondoh, Hitomi Watanabe, Norio Nakatsuji, Shinichiro Chuma PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice MOLECULAR AND CELLULAR BIOLOGY, 37, 23 MOLECULAR AND CELLULAR BIOLOGY, 37, 23 MOLECULAR AND CELLULAR BIOLOGY, 37, 23 2017/12 英語 研究論文(学術雑誌) 公開
Hiroyuki Niida, Ryoichi Matsunuma, Ryo Horiguchi, Chiharu Uchida, Yuka Nakazawa, Akira Motegi, Koji Nishimoto, Satoshi Sakai, Tatsuya Ohhata, Kyoko Kitagawa, Shinichi Moriwaki, Hideo Nishitani, Ayako Ui, Tomoo Ogi, Masatoshi Kitagawa Hiroyuki Niida, Ryoichi Matsunuma, Ryo Horiguchi, Chiharu Uchida, Yuka Nakazawa, Akira Motegi, Koji Nishimoto, Satoshi Sakai, Tatsuya Ohhata, Kyoko Kitagawa, Shinichi Moriwaki, Hideo Nishitani, Ayako Ui, Tomoo Ogi, Masatoshi Kitagawa Hiroyuki Niida, Ryoichi Matsunuma, Ryo Horiguchi, Chiharu Uchida, Yuka Nakazawa, Akira Motegi, Koji Nishimoto, Satoshi Sakai, Tatsuya Ohhata, Kyoko Kitagawa, Shinichi Moriwaki, Hideo Nishitani, Ayako Ui, Tomoo Ogi, Masatoshi Kitagawa Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair NATURE COMMUNICATIONS, 8, 16102 NATURE COMMUNICATIONS, 8, 16102 NATURE COMMUNICATIONS, 8, 16102 2017/07 英語 研究論文(学術雑誌) 公開
Junhui Wang, Qianshan Ding, Hiroaki Fujimori, Akira Motegi, Yoshio Miki, Mitsuko Masutani Junhui Wang, Qianshan Ding, Hiroaki Fujimori, Akira Motegi, Yoshio Miki, Mitsuko Masutani Junhui Wang, Qianshan Ding, Hiroaki Fujimori, Akira Motegi, Yoshio Miki, Mitsuko Masutani Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors ONCOTARGET, 7, 7, 7701-7713 ONCOTARGET, 7, 7, 7701-7713 ONCOTARGET, 7, 7, 7701-7713 2016/02 英語 研究論文(学術雑誌) 公開
S. Kobayashi, Y. Kasaishi, S. Nakada, T. Takagi, S. Era, A. Motegi, R. K. Chiu, S. Takeda, K. Hirota S. Kobayashi, Y. Kasaishi, S. Nakada, T. Takagi, S. Era, A. Motegi, R. K. Chiu, S. Takeda, K. Hirota S. Kobayashi, Y. Kasaishi, S. Nakada, T. Takagi, S. Era, A. Motegi, R. K. Chiu, S. Takeda, K. Hirota Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining ONCOGENE, 34, 33, 4403-4411 ONCOGENE, 34, 33, 4403-4411 ONCOGENE, 34, 33, 4403-4411 2015/08 英語 研究論文(学術雑誌) 公開
Michael Schmid, Jacqueline Smith, David W. Burt, Bronwen L. Aken, Parker B. Antin, Alan L. Archibald, Chris Ashwell, Perry J. Blackshear, Clarissa Boschiero, C. Titus Brown, Shane C. Burgess, Hans H. Cheng, William Chow, Derrick J. Coble, Amanda Cooksey, Richard P. M. A. Crooijmans, Joana Damas, Richard V. N. Davis, Dirk-Jan de Koning, Mary E. Delany, Thomas Derrien, Takele T. Desta, Ian C. Dunn, Matthew Dunn, Hans Ellegren, Lel Eoery, Ionas Erb, Marta Farre, Mario Fasold, Damarius Fleming, Paul Flicek, Katie E. Fowler, Laure Fresard, David P. Froman, Valerie Garceau, Paul P. Gardner, Almas A. Gheyas, Darren K. Griffin, Martien A. M. Groenen, Thomas Haaf, Olivier Hanotte, Alan Hart, Julien Haesler, S. Blair Hedges, Jana Hertel, Kerstin Howe, Allen Hubbard, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Christophe Klopp, Kalmia E. Kniel, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Denis M. Larkin, Raman A. Lawal, Sarah M. Markland, Fiona McCarthy, Heather A. McCormack, Marla C. McPherson, Akira Motegi, Stefan A. Muljo, Andrea Muensterberg, Rishi Nag, Indrajit Nanda, Michael Neuberger, Anne Nitsche, Cedric Notredame, Harry Noyes, Rebecca O'Connor, Elizabeth A. O'Hare, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Michael Persia, Frederique Pitel, Likit Preeyanon, Pablo Prieto Barja, Elizabeth M. Pritchett, Douglas D. Rhoads, Charmaine M. Robinson, Michael N. Romanov, Max Rothschild, Pierre-Francois Roux, Carl J. Schmidt, Alisa-Sophia Schneider, Matthew G. Schwartz, Steve M. Searle, Michael A. Skinner, Craig A. Smith, Peter F. Stadler, Tammy E. Steeves, Claus Steinlein, Liang Sun, Minoru Takata, Igor Ulitsky, Qing Wang, Ying Wang, Wesley C. Warren, Jonathan M. D. Wood, David Wragg, Huaijun Zhou Michael Schmid, Jacqueline Smith, David W. Burt, Bronwen L. Aken, Parker B. Antin, Alan L. Archibald, Chris Ashwell, Perry J. Blackshear, Clarissa Boschiero, C. Titus Brown, Shane C. Burgess, Hans H. Cheng, William Chow, Derrick J. Coble, Amanda Cooksey, Richard P. M. A. Crooijmans, Joana Damas, Richard V. N. Davis, Dirk-Jan de Koning, Mary E. Delany, Thomas Derrien, Takele T. Desta, Ian C. Dunn, Matthew Dunn, Hans Ellegren, Lel Eoery, Ionas Erb, Marta Farre, Mario Fasold, Damarius Fleming, Paul Flicek, Katie E. Fowler, Laure Fresard, David P. Froman, Valerie Garceau, Paul P. Gardner, Almas A. Gheyas, Darren K. Griffin, Martien A. M. Groenen, Thomas Haaf, Olivier Hanotte, Alan Hart, Julien Haesler, S. Blair Hedges, Jana Hertel, Kerstin Howe, Allen Hubbard, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Christophe Klopp, Kalmia E. Kniel, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Denis M. Larkin, Raman A. Lawal, Sarah M. Markland, Fiona McCarthy, Heather A. McCormack, Marla C. McPherson, Akira Motegi, Stefan A. Muljo, Andrea Muensterberg, Rishi Nag, Indrajit Nanda, Michael Neuberger, Anne Nitsche, Cedric Notredame, Harry Noyes, Rebecca O'Connor, Elizabeth A. O'Hare, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Michael Persia, Frederique Pitel, Likit Preeyanon, Pablo Prieto Barja, Elizabeth M. Pritchett, Douglas D. Rhoads, Charmaine M. Robinson, Michael N. Romanov, Max Rothschild, Pierre-Francois Roux, Carl J. Schmidt, Alisa-Sophia Schneider, Matthew G. Schwartz, Steve M. Searle, Michael A. Skinner, Craig A. Smith, Peter F. Stadler, Tammy E. Steeves, Claus Steinlein, Liang Sun, Minoru Takata, Igor Ulitsky, Qing Wang, Ying Wang, Wesley C. Warren, Jonathan M. D. Wood, David Wragg, Huaijun Zhou Michael Schmid, Jacqueline Smith, David W. Burt, Bronwen L. Aken, Parker B. Antin, Alan L. Archibald, Chris Ashwell, Perry J. Blackshear, Clarissa Boschiero, C. Titus Brown, Shane C. Burgess, Hans H. Cheng, William Chow, Derrick J. Coble, Amanda Cooksey, Richard P. M. A. Crooijmans, Joana Damas, Richard V. N. Davis, Dirk-Jan de Koning, Mary E. Delany, Thomas Derrien, Takele T. Desta, Ian C. Dunn, Matthew Dunn, Hans Ellegren, Lel Eoery, Ionas Erb, Marta Farre, Mario Fasold, Damarius Fleming, Paul Flicek, Katie E. Fowler, Laure Fresard, David P. Froman, Valerie Garceau, Paul P. Gardner, Almas A. Gheyas, Darren K. Griffin, Martien A. M. Groenen, Thomas Haaf, Olivier Hanotte, Alan Hart, Julien Haesler, S. Blair Hedges, Jana Hertel, Kerstin Howe, Allen Hubbard, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Christophe Klopp, Kalmia E. Kniel, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Denis M. Larkin, Raman A. Lawal, Sarah M. Markland, Fiona McCarthy, Heather A. McCormack, Marla C. McPherson, Akira Motegi, Stefan A. Muljo, Andrea Muensterberg, Rishi Nag, Indrajit Nanda, Michael Neuberger, Anne Nitsche, Cedric Notredame, Harry Noyes, Rebecca O'Connor, Elizabeth A. O'Hare, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Michael Persia, Frederique Pitel, Likit Preeyanon, Pablo Prieto Barja, Elizabeth M. Pritchett, Douglas D. Rhoads, Charmaine M. Robinson, Michael N. Romanov, Max Rothschild, Pierre-Francois Roux, Carl J. Schmidt, Alisa-Sophia Schneider, Matthew G. Schwartz, Steve M. Searle, Michael A. Skinner, Craig A. Smith, Peter F. Stadler, Tammy E. Steeves, Claus Steinlein, Liang Sun, Minoru Takata, Igor Ulitsky, Qing Wang, Ying Wang, Wesley C. Warren, Jonathan M. D. Wood, David Wragg, Huaijun Zhou Third Report on Chicken Genes and Chromosomes 2015 Third Report on Chicken Genes and Chromosomes 2015 Third Report on Chicken Genes and Chromosomes 2015 CYTOGENETIC AND GENOME RESEARCH, 145, 2, 78-179 CYTOGENETIC AND GENOME RESEARCH, 145, 2, 78-179 CYTOGENETIC AND GENOME RESEARCH, 145, 2, 78-179 2015 英語 研究論文(学術雑誌) 公開
Akira Motegi, Minoru Takata Akira Motegi, Minoru Takata Akira Motegi, Minoru Takata Multiple genetic manipulations of DT40 cell line Multiple genetic manipulations of DT40 cell line Multiple genetic manipulations of DT40 cell line Methods in Molecular Biology, 1114, 25-35 Methods in Molecular Biology, 1114, 25-35 Methods in Molecular Biology, 1114, 25-35 2014/01/01 英語 研究論文(学術雑誌) 公開
Saho Era, Takuya Abe, Hiroshi Arakawa, Shunsuke Kobayashi, Barnabas Szakal, Yusuke Yoshikawa, Akira Motegi, Shunichi Takeda, Dana Branzei Saho Era, Takuya Abe, Hiroshi Arakawa, Shunsuke Kobayashi, Barnabas Szakal, Yusuke Yoshikawa, Akira Motegi, Shunichi Takeda, Dana Branzei Saho Era, Takuya Abe, Hiroshi Arakawa, Shunsuke Kobayashi, Barnabas Szakal, Yusuke Yoshikawa, Akira Motegi, Shunichi Takeda, Dana Branzei The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 426, 3, 310-316 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 426, 3, 310-316 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 426, 3, 310-316 2012/09 英語 研究論文(学術雑誌) 公開
Susanne M. Germann, Vibe H. Oestergaard, Caroline Haas, Pauline Salis, Akira Motegi, Michael Lisby Susanne M. Germann, Vibe H. Oestergaard, Caroline Haas, Pauline Salis, Akira Motegi, Michael Lisby Susanne M. Germann, Vibe H. Oestergaard, Caroline Haas, Pauline Salis, Akira Motegi, Michael Lisby Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination DNA REPAIR, 10, 2, 210-224 DNA REPAIR, 10, 2, 210-224 DNA REPAIR, 10, 2, 210-224 2011/02 英語 研究論文(学術雑誌) 公開
K. Hirota, E. Sonoda, T. Kawamoto, A. Motegi, C. Masutani, F. Hanaoka, D. Szüts, S. Iwai, J.E. Sale, A. Lehmann, S. Takeda K. Hirota, E. Sonoda, T. Kawamoto, A. Motegi, C. Masutani, F. Hanaoka, D. Szüts, S. Iwai, J.E. Sale, A. Lehmann, S. Takeda Kouji Hirota, Eiichiro Sonoda, Takuo Kawamoto, Akira Motegi, Chikahide Masutani, Fumio Hanaoka, Dávid Szüts, Shigenori Iwai, Julian E Sale, Alan Lehmann, Shunichi Takeda Simultaneous disruption of two DNA polymerases, Polη and Polζ, in avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions Simultaneous disruption of two DNA polymerases, Polη and Polζ, in avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions. PLoS Genetics, 6, 10, 1-13 PLoS Genetics, 6, 10, 1-13 PLoS genetics, 6, 10, 1-13 2010/10/07 英語 公開
Kouji Hirota, Eiichiro Sonoda, Takuo Kawamoto, Akira Motegi, Chikahide Masutani, Fumio Hanaoka, David Szuets, Shigenori Iwai, Julian E. Sale, Alan Lehmann, Shunichi Takeda Kouji Hirota, Eiichiro Sonoda, Takuo Kawamoto, Akira Motegi, Chikahide Masutani, Fumio Hanaoka, David Szuets, Shigenori Iwai, Julian E. Sale, Alan Lehmann, Shunichi Takeda Kouji Hirota, Eiichiro Sonoda, Takuo Kawamoto, Akira Motegi, Chikahide Masutani, Fumio Hanaoka, David Szuets, Shigenori Iwai, Julian E. Sale, Alan Lehmann, Shunichi Takeda Simultaneous Disruption of Two DNA Polymerases, Pol eta and Pol zeta, in Avian DT40 Cells Unmasks the Role of Pol eta in Cellular Response to Various DNA Lesions Simultaneous Disruption of Two DNA Polymerases, Pol eta and Pol zeta, in Avian DT40 Cells Unmasks the Role of Pol eta in Cellular Response to Various DNA Lesions Simultaneous Disruption of Two DNA Polymerases, Pol eta and Pol zeta, in Avian DT40 Cells Unmasks the Role of Pol eta in Cellular Response to Various DNA Lesions PLOS GENETICS, 6, 10, e1001151 PLOS GENETICS, 6, 10, e1001151 PLOS GENETICS, 6, 10, e1001151 2010/10 英語 研究論文(学術雑誌) 公開
Akira Motegi, Yasuhiro Murakawa, Shunichi Takeda Akira Motegi, Yasuhiro Murakawa, Shunichi Takeda Akira Motegi, Yasuhiro Murakawa, Shunichi Takeda The vital link between the ubiquitin-proteasome pathway and DNA repair: Impact on cancer therapy The vital link between the ubiquitin-proteasome pathway and DNA repair: Impact on cancer therapy The vital link between the ubiquitin-proteasome pathway and DNA repair: Impact on cancer therapy CANCER LETTERS, 283, 1, 1-9 CANCER LETTERS, 283, 1, 1-9 CANCER LETTERS, 283, 1, 1-9 2009/09 英語 公開
A. Motegi, S. Takeda A. Motegi, S. Takeda A. Motegi, S. Takeda [Function of homologous recombination-mediated DNA repair]. [Function of homologous recombination-mediated DNA repair]. [Function of homologous recombination-mediated DNA repair]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 4 Suppl, 450-458 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 4 Suppl, 450-458 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 4 Suppl, 450-458 2009/03 英語 公開
Akira Motegi Akira Motegi Akira Motegi Maintenance of genome stability though ubcl3-dependent ubiquitination Maintenance of genome stability though ubcl3-dependent ubiquitination Maintenance of genome stability though ubcl3-dependent ubiquitination Seikagaku, 81, 7, 601-605 Seikagaku, 81, 7, 601-605 Seikagaku, 81, 7, 601-605 2009 日本語 公開
Akira Motegi, Hung-Jiun Liaw, Kyoo-Young Lee, Henk P. Roest, Alex Maas, Xiaoli Wu, Helen Moinova, Sanford D. Markowitz, Hao Ding, Jan H. J. Hoeijmakers, Kyungjae Myung Akira Motegi, Hung-Jiun Liaw, Kyoo-Young Lee, Henk P. Roest, Alex Maas, Xiaoli Wu, Helen Moinova, Sanford D. Markowitz, Hao Ding, Jan H. J. Hoeijmakers, Kyungjae Myung Akira Motegi, Hung-Jiun Liaw, Kyoo-Young Lee, Henk P. Roest, Alex Maas, Xiaoli Wu, Helen Moinova, Sanford D. Markowitz, Hao Ding, Jan H. J. Hoeijmakers, Kyungjae Myung Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105, 34, 12411-12416 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105, 34, 12411-12416 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105, 34, 12411-12416 2008/08 英語 研究論文(学術雑誌) 公開
Soma Banerjee, Stephanie Smith, Ji-Hyun Oum, Hung-Jiun Liaw, Ji-Young Hwang, Nilabja Sikdar, Akira Motegi, Sang Eun Lee, Kyungjae Myung Soma Banerjee, Stephanie Smith, Ji-Hyun Oum, Hung-Jiun Liaw, Ji-Young Hwang, Nilabja Sikdar, Akira Motegi, Sang Eun Lee, Kyungjae Myung Soma Banerjee, Stephanie Smith, Ji-Hyun Oum, Hung-Jiun Liaw, Ji-Young Hwang, Nilabja Sikdar, Akira Motegi, Sang Eun Lee, Kyungjae Myung Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination JOURNAL OF CELL BIOLOGY, 181, 7, 1083-1093 JOURNAL OF CELL BIOLOGY, 181, 7, 1083-1093 JOURNAL OF CELL BIOLOGY, 181, 7, 1083-1093 2008/06 英語 研究論文(学術雑誌) 公開
Akira Motegi, Kyungjae Myung Akira Motegi, Kyungjae Myung Akira Motegi, Kyungjae Myung Measuring the rate of gross chromosomal rearrangements in Saccharomyces cerevisiae: A practical approach to study genomic rearrangements observed in cancer Measuring the rate of gross chromosomal rearrangements in Saccharomyces cerevisiae: A practical approach to study genomic rearrangements observed in cancer Measuring the rate of gross chromosomal rearrangements in Saccharomyces cerevisiae: A practical approach to study genomic rearrangements observed in cancer METHODS, 41, 2, 168-176 METHODS, 41, 2, 168-176 METHODS, 41, 2, 168-176 2007/02 英語 研究論文(学術雑誌) 公開
Clark C. Chen, Akira Motegi, Yuko Hasegawa, Kyungjae Myung, Richard Kolodner, Alan D'Andrea Clark C. Chen, Akira Motegi, Yuko Hasegawa, Kyungjae Myung, Richard Kolodner, Alan D'Andrea Clark C. Chen, Akira Motegi, Yuko Hasegawa, Kyungjae Myung, Richard Kolodner, Alan D'Andrea Genetic analysis of ionizing radiation-induced mutagenesis in Saccharomyces cerevisiae reveals TransLesion Synthesis (TLS) independent of PCNA K164SUMOylation and ubiquitination Genetic analysis of ionizing radiation-induced mutagenesis in Saccharomyces cerevisiae reveals TransLesion Synthesis (TLS) independent of PCNA K164SUMOylation and ubiquitination Genetic analysis of ionizing radiation-induced mutagenesis in Saccharomyces cerevisiae reveals TransLesion Synthesis (TLS) independent of PCNA K164SUMOylation and ubiquitination DNA REPAIR, 5, 12, 1475-1488 DNA REPAIR, 5, 12, 1475-1488 DNA REPAIR, 5, 12, 1475-1488 2006/12 英語 研究論文(学術雑誌) 公開
Akira Motegi, Raman Sood, Helen Moinova, Sanford D. Markowitz, Pu Paul Liu, Kyungjae Myung Akira Motegi, Raman Sood, Helen Moinova, Sanford D. Markowitz, Pu Paul Liu, Kyungjae Myung Akira Motegi, Raman Sood, Helen Moinova, Sanford D. Markowitz, Pu Paul Liu, Kyungjae Myung Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination JOURNAL OF CELL BIOLOGY, 175, 5, 703-708 JOURNAL OF CELL BIOLOGY, 175, 5, 703-708 JOURNAL OF CELL BIOLOGY, 175, 5, 703-708 2006/12 英語 研究論文(学術雑誌) 公開
A Motegi, K Kuntz, A Majeed, S Smith, K Myung A Motegi, K Kuntz, A Majeed, S Smith, K Myung A Motegi, K Kuntz, A Majeed, S Smith, K Myung Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae MOLECULAR AND CELLULAR BIOLOGY, 26, 4, 1424-1433 MOLECULAR AND CELLULAR BIOLOGY, 26, 4, 1424-1433 MOLECULAR AND CELLULAR BIOLOGY, 26, 4, 1424-1433 2006/02 英語 研究論文(学術雑誌) 公開
Clark Chen, Akira Motegi, Yuko Hasegawa, Richard Kolodner, Kyungjae Myung, Alan D’Andrea Clark Chen, Akira Motegi, Yuko Hasegawa, Richard Kolodner, Kyungjae Myung, Alan D’Andrea Clark Chen, Akira Motegi, Yuko Hasegawa, Richard Kolodner, Kyungjae Myung, Alan D’Andrea Genetic analysis of ionization-induced mutagenesis in Saccharomyces cerevisiae revealed a complex network of overlapping mutagenic pathways Genetic analysis of ionization-induced mutagenesis in Saccharomyces cerevisiae revealed a complex network of overlapping mutagenic pathways Genetic analysis of ionization-induced mutagenesis in Saccharomyces cerevisiae revealed a complex network of overlapping mutagenic pathways DNA Repair 5:1475-1488 (2006) DNA Repair 5:1475-1488 (2006) DNA Repair 5:1475-1488 (2006) 2006 英語 公開
A Motegi, J Fujimoto, M Kotani, H Sakuraba, T Yamamoto A Motegi, J Fujimoto, M Kotani, H Sakuraba, T Yamamoto A Motegi, J Fujimoto, M Kotani, H Sakuraba, T Yamamoto ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth JOURNAL OF CELL SCIENCE, 117, 15, 3319-3329 JOURNAL OF CELL SCIENCE, 117, 15, 3319-3329 JOURNAL OF CELL SCIENCE, 117, 15, 3319-3329 2004/07 英語 研究論文(学術雑誌) 公開
P Olsson, A Motegi, TK Bera, B Lee, Pastan, I P Olsson, A Motegi, TK Bera, B Lee, Pastan, I P Olsson, A Motegi, TK Bera, B Lee, Pastan, I PRAC2: A new gene expressed in human prostate and prostate cancer PRAC2: A new gene expressed in human prostate and prostate cancer PRAC2: A new gene expressed in human prostate and prostate cancer PROSTATE, 56, 2, 123-130 PROSTATE, 56, 2, 123-130 PROSTATE, 56, 2, 123-130 2003/07 英語 研究論文(学術雑誌) 公開

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タイトル言語:
Misc
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Wang Junhui, 茂木 章, 藤森 浩彰, 三木 義男, 益谷 美都子 Wang Junhui, 茂木 章, 藤森 浩彰, 三木 義男, 益谷 美都子 Wang Junhui, 茂木 章, 藤森 浩彰, 三木 義男, 益谷 美都子 PARP-1とPARGは放射線応答において53BP1の制御に関与する(PARP-1 and PARG are both required for the regulation of 53BP1 after IR) PARP-1とPARGは放射線応答において53BP1の制御に関与する(PARP-1 and PARG are both required for the regulation of 53BP1 after IR) PARP-1とPARGは放射線応答において53BP1の制御に関与する(PARP-1 and PARG are both required for the regulation of 53BP1 after IR) 日本癌学会総会記事, 73回, J-3008 日本癌学会総会記事, 73回, J-3008 日本癌学会総会記事, 73回, J-3008 2014/09 英語 公開
Wang Junhui, 茂木 章, 藤森 浩彰, 三木 義男, 益谷 美都子 Wang Junhui, 茂木 章, 藤森 浩彰, 三木 義男, 益谷 美都子 Wang Junhui, 茂木 章, 藤森 浩彰, 三木 義男, 益谷 美都子 PARP-1は5'-及び3'-ブロック2本鎖切断端からのCtIPが関与する過剰なエンドリセクションを抑制する(PARP-1 suppresses the end-resection of 5'- and 3'-blocked termini of double-strand DNA breaks by CtIP) PARP-1は5'-及び3'-ブロック2本鎖切断端からのCtIPが関与する過剰なエンドリセクションを抑制する(PARP-1 suppresses the end-resection of 5'- and 3'-blocked termini of double-strand DNA breaks by CtIP) PARP-1は5'-及び3'-ブロック2本鎖切断端からのCtIPが関与する過剰なエンドリセクションを抑制する(PARP-1 suppresses the end-resection of 5'- and 3'-blocked termini of double-strand DNA breaks by CtIP) 日本癌学会総会記事, 72回, 116-116 日本癌学会総会記事, 72回, 116-116 日本癌学会総会記事, 72回, 116-116 2013/10 英語 公開
足立淳, 鳴海良平, 佐野聖三, 久家貴寿, 白水崇, 松本雅記, 中山敬一, 茂木章, 井倉毅, 高田穣, 朝長毅 足立淳, 鳴海良平, 佐野聖三, 久家貴寿, 白水崇, 松本雅記, 中山敬一, 茂木章, 井倉毅, 高田穣, 朝長毅 「DNA 損傷応答ネットワークにおけるリン酸化・ユビキチン化修飾ダイナミクスのプロテオーム解析」 「DNA 損傷応答ネットワークにおけるリン酸化・ユビキチン化修飾ダイナミクスのプロテオーム解析」 第33 回日本分子生物学会年会第83 回「」本生化学会大会合同大会 2010 年12 月 第33 回日本分子生物学会年会第83 回「」本生化学会大会合同大会 2010 年12 月 2010 日本語 公開
タイトル言語:
学術賞等
賞の名称(日本語) 賞の名称(英語) 授与組織名(日本語) 授与組織名(英語) 年月
2005 Keystone Symposia Scholarship Award 2005
外部資金:競争的資金 (科学研究費補助金)
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
基盤研究(A) 分担 ニワトリ細胞株DT40の遺伝子破壊による、DNA損傷への応答機構の網羅的解析 Analysis of DNA damage response using gene-disrupted DT40 clones. 2008〜2010
基盤研究(C) 代表 ユビキチン化によるDNA修復制御機構の解明 2010〜2012
若手スタートアップ研究 代表 ユビキチン化によるDNA複製停止解除の制御機構の解明 Ubiquitin-dependent regulation of DNA replication arrest 2013〜2016
基盤研究(C) 代表 DNA複製阻害を解除する損傷トレランス機構の解明 2013〜2015
基盤研究(C) 代表 DNA複製阻害を解除する損傷トレランス機構の解明 (平成26年度分) 2014/04/01〜2015/03/31
基盤研究(C) 代表 DNA複製阻害を解除する損傷トレランス機構の解明 (平成27年度分) 2015/04/01〜2016/03/31
基盤研究(C) 代表 DNA複製阻害を解除する損傷トレランス機構の解明 (平成28年度分) 2016/04/01〜2017/03/31
基盤研究(C) 代表 鋳型乗り換え経路によるゲノム維持機構の解明 (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(C) 代表 鋳型乗り換え経路によるゲノム維持機構の解明 (平成30年度分) 2018/04/01〜2019/03/31
基盤研究(C) 代表 鋳型乗り換え経路によるゲノム維持機構の解明 (2019年度分) 2019/04/01〜2020/03/31
基盤研究(C) 代表 鋳型乗り換え経路によるゲノム維持機構の解明 (2020年度分) 2020/04/01〜2021/03/31

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全学運営(役職等)
役職名 期間
京都大学無機廃液処理装置(KMS)指導員
エネルギー管理要員
放射線障害予防小委員会 2017/04/01〜2019/03/31
部局運営(役職等)
役職名 期間
医学図書館連絡委員 〜2019/03/31
放射線障害防止委員会