宮本 章歳

最終更新日時: 2020/07/30 08:28:43

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氏名(漢字／フリガナ／アルファベット表記)
宮本 章歳／ミヤモト アキトシ／Miyamoto, Akitoshi
所属部署・職名(部局／所属／講座等／職名)
生命科学研究科／高次生命科学専攻認知情報学講座／助教
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士（生命科学） 東京大学 The University of Tokyo
博士（医学） 東京大学 The University of Tokyo
プロフィール
(日本語)
超解像イメージング技術を用いて神経ネットワーク制御機構の解明を行なっている。教育に関しては、大学院の学生に実験ノートの書き方を始め、実験の原理原則をしっかりと教える事で、自ら考え学び行動できる自立した研究者になれるように指導している。
(英語)
I am conducting research on neurobiology by using super resolution microscopy in Kyoto university. As for education, I teach graduate students how to write research notebook and fundamental principles of experiments to help them acquire essential skills and knowledge needed to become good researchers.
使用言語
言語名(japanese) 言語名(english) コード
日本語 Japanese jpn
英語 English eng
researchmap URL
https://researchmap.jp/aki-miya
研究テーマ
(日本語)
革新的超解像イメージング法を用いた脳神経ネットワーク機能の解明
(英語)
Elucidating the regulatory machinery of neuronal network by using
研究概要
(日本語)
シナプス伝達の強弱を決めるシナプス可塑性は記憶・学習の基盤である。神経細胞には、シナプスで情報を受け取るスパインと呼ばれる構造があり、スパインの形態がシナプス可塑性を制御する。そこで、我々はIRISを用いて、スパインに局在するタンパク質群の局在を詳細に解析する事で、スパイン形態制御を介したシナプス可塑性制御機構の解明を目指す。
(英語)
Synaptic plasticity has a fundamental roles on learning and memory formation. Neuron has a lot of small membranous protrusion called spine that receives information from a single axon. The shape and size of spine controls synaptic plasticity. Thus I want to visualize precise distributions and interactions of functional proteins that control the structure of spine by using a novel super resolution microscopy, IRIS, and clarify the regulatory roles of synaptic plasticity.
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Toru Matsu-ura, Hideki Shirakawa, Kenichi G, N. Suzuki, Akitoshi Miyamoto, Kotomi Sugiura, Takayuki Michikawa, Akihiro Kusumi, Katsuhiko Mikoshiba Toru Matsu-ura, Hideki Shirakawa, Kenichi G, N. Suzuki, Akitoshi Miyamoto, Kotomi Sugiura, Takayuki Michikawa, Akihiro Kusumi, Katsuhiko Mikoshiba Dual-FRET imaging of IP3 and Ca2+ revealed Ca2+-induced IP3 production maintains long lasting Ca2+ oscillations in fertilized mouse eggs Dual-FRET imaging of IP3 and Ca2+ revealed Ca2+-induced IP3 production maintains long lasting Ca2+ oscillations in fertilized mouse eggs Dual-FRET imaging of IP3 and Ca2+ revealed Ca2+-induced IP3 production maintains long lasting Ca2+ oscillations in fertilized mouse eggs Scientific Reports, 9, 4829 Scientific Reports, 9, 4829 Scientific Reports, 9, 4829 2019 有 英語 研究論文(学術雑誌) 公開
Akitoshi Miyamoto, Katsuhiko Mikoshiba Akitoshi Miyamoto, Katsuhiko Mikoshiba A novel multi lines analysis tool of Ca2+ dynamics reveals the nonuniformity of Ca2+ propagation. A novel multi lines analysis tool of Ca2+ dynamics reveals the nonuniformity of Ca2+ propagation. A novel multi lines analysis tool of Ca2+ dynamics reveals the nonuniformity of Ca2+ propagation. Cell Calcium, 78, 76-80 Cell Calcium, 78, 76-80 Cell Calcium, 78, 76-80 2019 有 英語 研究論文(学術雑誌) 公開
Jillian P.Casey, Taisei Hirouchi, Chihiro Hisatsune, Bryan Lynch, Raymond Murphy, Ainee M. Dunne, Akitoshi Miyamoto, Sean Ennis, Nick var der Spek, Bronagh O’Hici, Katsuhiko Mikoshiba, Sally Ann Lynch Jillian P.Casey, Taisei Hirouchi, Chihiro Hisatsune, Bryan Lynch, Raymond Murphy, Ainee M. Dunne, Akitoshi Miyamoto, Sean Ennis, Nick var der Spek, Bronagh O’Hici, Katsuhiko Mikoshiba, Sally Ann Lynch A novel gain-of-function mutation if the ITPR1 suppressor domain causes spinocerebellar ataxia with altered Ca2+ signal patterns. A novel gain-of-function mutation if the ITPR1 suppressor domain causes spinocerebellar ataxia with altered Ca2+ signal patterns. A novel gain-of-function mutation if the ITPR1 suppressor domain causes spinocerebellar ataxia with altered Ca2+ signal patterns. Journal of Neurology, 10.1007/s00415-017-8545-5 Journal of Neurology, 10.1007/s00415-017-8545-5 Journal of Neurology, 10.1007/s00415-017-8545-5 2017 有 英語 研究論文(学術雑誌) 公開
Akitoshi Miyamoto, Katsuhiko Mikoshiba Akitoshi Miyamoto, Katsuhiko Mikoshiba Probes for manipulating and monitoring IP3. Probes for manipulating and monitoring IP3. Probes for manipulating and monitoring IP3. Cell Calcium, S0143-4160(16)30188-9 Cell Calcium, S0143-4160(16)30188-9 Cell Calcium, S0143-4160(16)30188-9 2016 有 英語 研究論文(学術雑誌) 公開
Akitoshi Miyamoto, Kotomi Sugiura, Katsuhiko Mikoshiba Akitoshi Miyamoto, Kotomi Sugiura, Katsuhiko Mikoshiba Development of a convenient and supersensitive high-throughput screening system for genetically encoded fluorescent probes of small molecules using a confocal microscope. Development of a convenient and supersensitive high-throughput screening system for genetically encoded fluorescent probes of small molecules using a confocal microscope. Development of a convenient and supersensitive high-throughput screening system for genetically encoded fluorescent probes of small molecules using a confocal microscope. Cell Calcium, 61, 1-9 Cell Calcium, 61, 1-9 Cell Calcium, 61, 1-9 2016 有 英語 研究論文(学術雑誌) 公開
Ryo Ushioda, Akitoshi Miyamoto, These authors contributed equally to this work, Michio Inoue, Satoshi Watanabe, Masaki Okumura, Ken-ichi Maegawa, Kaiku Uegaki, Shohei Fujii, Yasuko Fukuda, Masataka Umitsu, Jun-ichi Takagi, Kenji Inaba, Katsuhiko Mikoshiba, Kazuhiro Nagata Ryo Ushioda, Akitoshi Miyamoto, These authors contributed equally to this work, Michio Inoue, Satoshi Watanabe, Masaki Okumura, Ken-ichi Maegawa, Kaiku Uegaki, Shohei Fujii, Yasuko Fukuda, Masataka Umitsu, Jun-ichi Takagi, Kenji Inaba, Katsuhiko Mikoshiba, Kazuhiro Nagata Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by ERdj5 Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by ERdj5 Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by ERdj5 Proc Natl Acad Sci U S A., 113, 41, E6055-E6063 Proc Natl Acad Sci U S A., 113, 41, E6055-E6063 Proc Natl Acad Sci U S A., 113, 41, E6055-E6063 2016 有 英語 研究論文(学術雑誌) 公開
Hiroko Bannai, Fumihiro Niwa, Mark W Sherwood, Amulya Nidhi Shrivastava, Misa Arizono, Akitoshi Miyamoto, Kotomi Sugiura, Sabine Lévi, Antoine Triller, Katsuhiko Mikoshiba Hiroko Bannai, Fumihiro Niwa, Mark W Sherwood, Amulya Nidhi Shrivastava, Misa Arizono, Akitoshi Miyamoto, Kotomi Sugiura, Sabine Lévi, Antoine Triller, Katsuhiko Mikoshiba Differential calcium-dependent control of synaptic GABAA receptor clustering by ionotropic and metabotropic glutamate receptors Differential calcium-dependent control of synaptic GABAA receptor clustering by ionotropic and metabotropic glutamate receptors Differential calcium-dependent control of synaptic GABAA receptor clustering by ionotropic and metabotropic glutamate receptors Cell Reports, 13, 12, 2768-2780 Cell Reports, 13, 12, 2768-2780 Cell Reports, 13, 12, 2768-2780 2015 有 英語 研究論文(学術雑誌) 公開
Akitoshi Miyamoto, Hiroko Bannai, Takayuki Michikawa, Katsuhiko Mikoshiba Akitoshi Miyamoto, Hiroko Bannai, Takayuki Michikawa, Katsuhiko Mikoshiba 遺伝子コード型カルシウムセンサーを用いた長時間細胞内カルシウムイメージングに最適な顕微鏡システムの検証 遺伝子コード型カルシウムセンサーを用いた長時間細胞内カルシウムイメージングに最適な顕微鏡システムの検証 Optimal microscopic systems for long-term imaging of intracellular calcium using a ratiometric genetically-encoded calcium indicator BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 434, 2, 252-257 , 434, 2, 252-257 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 434, 2, 252-257 2013/05 有 英語 研究論文(学術雑誌) 公開
Misa Arizono, Hiroko Bannai, Kyoko Nakamura, Fumihiro Niwa, Masahiro Enomoto, Toru Matsu-ura, Akitoshi Miyamoto, Mark W. Sherwood, Takeshi Nakamura, Katsuhiko Mikoshiba Misa Arizono, Hiroko Bannai, Kyoko Nakamura, Fumihiro Niwa, Masahiro Enomoto, Toru Matsu-ura, Akitoshi Miyamoto, Mark W. Sherwood, Takeshi Nakamura, Katsuhiko Mikoshiba Misa Arizono, Hiroko Bannai, Kyoko Nakamura, Fumihiro Niwa, Masahiro Enomoto, Toru Matsu-ura, Akitoshi Miyamoto, Mark W. Sherwood, Takeshi Nakamura, Katsuhiko Mikoshiba Receptor-Selective Diffusion Barrier Enhances Sensitivity of Astrocytic Processes to Metabotropic Glutamate Receptor Stimulation Receptor-Selective Diffusion Barrier Enhances Sensitivity of Astrocytic Processes to Metabotropic Glutamate Receptor Stimulation Receptor-Selective Diffusion Barrier Enhances Sensitivity of Astrocytic Processes to Metabotropic Glutamate Receptor Stimulation SCIENCE SIGNALING, 5, 218 SCIENCE SIGNALING, 5, 218 SCIENCE SIGNALING, 5, 218 2012/04 有 英語 研究論文(学術雑誌) 公開
Tadashi Shinohara, Takayuki Michikawa, Masahiro Enomoto, Jun-Ichi Goto, Miwako Iwai, Toru Matsu-ura, Haruka Yamazaki, Akitoshi Miyamoto, Akio Suzuki, Katsuhiko Mikoshiba Tadashi Shinohara, Takayuki Michikawa, Masahiro Enomoto, Jun-Ichi Goto, Miwako Iwai, Toru Matsu-ura, Haruka Yamazaki, Akitoshi Miyamoto, Akio Suzuki, Katsuhiko Mikoshiba Tadashi Shinohara, Takayuki Michikawa, Masahiro Enomoto, Jun-Ichi Goto, Miwako Iwai, Toru Matsu-ura, Haruka Yamazaki, Akitoshi Miyamoto, Akio Suzuki, Katsuhiko Mikoshiba Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 37, 15486-15491 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 37, 15486-15491 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 37, 15486-15491 2011/09 有 英語 研究論文(学術雑誌) 公開
タイトル言語:
学術賞等
賞の名称(日本語) 賞の名称(英語) 授与組織名(日本語) 授与組織名(英語) 年月
YoungGlia Platinum Award 新学術領域「グリアアセンブリによる脳機能発現の制御と病態」 Glial Assembly: a New Regulatory Machinery of Brain Function and Disorders 2016/01/11
その他活動：国・地方公共団体での活動
委員会名(日本語) 委員会名(英語) 役職名 公共団体の名称 期間
和光市体育協会役員会 幹事 和光市体育協会 2016/04/01〜2018/03/31

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