秋葉 宏樹

最終更新日時: 2021/07/20 13:00:53

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氏名(漢字/フリガナ/アルファベット表記)
秋葉 宏樹/アキバ ヒロキ/Akiba, Hiroki
所属部署・職名(部局/所属/講座等/職名)
薬学研究科/ /助教
学部兼担
部局 所属 講座等 職名
薬学部
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士(工学) 東京大学
博士(工学) 東京大学
出身大学院・研究科等
大学名(日本語) 大学名(英語) 研究科名(日本語) 研究科名(英語) 専攻名(日本語) 専攻名(英語) 修了区分
東京大学 The University of Tokyo 大学院工学系研究科化学生命工学専攻修士課程 School of Engineering Department of Chemistry and Biotechnology 修了
東京大学 The University of Tokyo 大学院工学系研究科先端学際工学専攻博士課程 School of Engineering Department of Advanced Interdisciplinary Studies 修了
使用言語
言語名(japanese) 言語名(english) コード
日本語 Japanese jpn
英語 English eng
ORCID ID
https://orcid.org/0000-0002-1450-5873
researchmap URL
https://researchmap.jp/HirokiAkiba
研究テーマ
(日本語)
抗体医薬品の最適化と新規バイオ医薬品モダリティの創出研究
(英語)
Optimization of antibody therapeutics and generation of novel pharmaceutical modality based on biologics
研究概要
(日本語)
抗体医薬品の機能や性質を最適化するための変異導入、二重特異性分子の設計、分子修飾などの方法論の創出、ならびに実用化を促進するための分子デザインの実践を行っている。さらに、これまでに実用化されていない方法に抗体等バイオ医薬品を応用していくために、その機能メカニズムを化学的に変換する方法を研究している。
(英語)
I employ chemical and biochemical techniques to optimize and alter the functions of antibody therapeutics.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
蛋白質工学 Protein engineering
抗体医薬品 Antibody therapeutics
コンジュゲート化学 Bioconjugate chemistry
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Takeharu Minamitani, Karin Kiyose, Ryota Otsubo, Toshihiro Ito, Hiroki Akiba, Rika A. Furuta, Tsuyoshi Inoue, Kouhei Tsumoto, Masahiro Satake, Teruhito Yasui Takeharu Minamitani, Karin Kiyose, Ryota Otsubo, Toshihiro Ito, Hiroki Akiba, Rika A. Furuta, Tsuyoshi Inoue, Kouhei Tsumoto, Masahiro Satake, Teruhito Yasui Takeharu Minamitani, Karin Kiyose, Ryota Otsubo, Toshihiro Ito, Hiroki Akiba, Rika A. Furuta, Tsuyoshi Inoue, Kouhei Tsumoto, Masahiro Satake, Teruhito Yasui Novel neutralizing human monoclonal antibodies against tetanus neurotoxin Novel neutralizing human monoclonal antibodies against tetanus neurotoxin Novel neutralizing human monoclonal antibodies against tetanus neurotoxin Scientific Reports, 11, 1 Scientific Reports, 11, 1 Scientific Reports, 11, 1 2021/12 研究論文(学術雑誌) 公開
Mitsunobu Tanaka, Takaaki Abe, Takeharu Minamitani, Hiroki Akiba, Toshihiro Horikawa, Ryutaro Tobita, Kazumi Isa, Kenichi Ogasawara, Hideo Takahashi, Hidemi Tateyama, Satomi Tone, Kouhei Tsumoto, Teruhito Yasui, Takafumi Kimura, Yoshihiro Fujimura, Fumiya Hirayama, Yoshihiko Tani, Yoshihiro Takihara Mitsunobu Tanaka, Takaaki Abe, Takeharu Minamitani, Hiroki Akiba, Toshihiro Horikawa, Ryutaro Tobita, Kazumi Isa, Kenichi Ogasawara, Hideo Takahashi, Hidemi Tateyama, Satomi Tone, Kouhei Tsumoto, Teruhito Yasui, Takafumi Kimura, Yoshihiro Fujimura, Fumiya Hirayama, Yoshihiko Tani, Yoshihiro Takihara Mitsunobu Tanaka, Takaaki Abe, Takeharu Minamitani, Hiroki Akiba, Toshihiro Horikawa, Ryutaro Tobita, Kazumi Isa, Kenichi Ogasawara, Hideo Takahashi, Hidemi Tateyama, Satomi Tone, Kouhei Tsumoto, Teruhito Yasui, Takafumi Kimura, Yoshihiro Fujimura, Fumiya Hirayama, Yoshihiko Tani, Yoshihiro Takihara The Kg‐antigen, RhAG with a Lys164Gln mutation, gives rise to haemolytic disease of the newborn The Kg‐antigen, RhAG with a Lys164Gln mutation, gives rise to haemolytic disease of the newborn The Kg‐antigen, RhAG with a Lys164Gln mutation, gives rise to haemolytic disease of the newborn British Journal of Haematology British Journal of Haematology British Journal of Haematology 2020/07/23 研究論文(学術雑誌) 公開
Jinbing Xie, Daniel Gonzalez-Carter, Theofilus A. Tockary, Noriko Nakamura, Yonger Xue, Makoto Nakakido, Hiroki Akiba, Anjaneyulu Dirisala, Xueying Liu, Kazuko Toh, Tao Yang, Zengtao Wang, Shigeto Fukushima, Junjie Li, Sabina Quader, Kouhei Tsumoto, Takanori Yokota, Yasutaka Anraku, Kazunori Kataoka Jinbing Xie, Daniel Gonzalez-Carter, Theofilus A. Tockary, Noriko Nakamura, Yonger Xue, Makoto Nakakido, Hiroki Akiba, Anjaneyulu Dirisala, Xueying Liu, Kazuko Toh, Tao Yang, Zengtao Wang, Shigeto Fukushima, Junjie Li, Sabina Quader, Kouhei Tsumoto, Takanori Yokota, Yasutaka Anraku, Kazunori Kataoka Jinbing Xie, Daniel Gonzalez-Carter, Theofilus A. Tockary, Noriko Nakamura, Yonger Xue, Makoto Nakakido, Hiroki Akiba, Anjaneyulu Dirisala, Xueying Liu, Kazuko Toh, Tao Yang, Zengtao Wang, Shigeto Fukushima, Junjie Li, Sabina Quader, Kouhei Tsumoto, Takanori Yokota, Yasutaka Anraku, Kazunori Kataoka Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain ACS Nano, 14, 6, 6729-6742 ACS Nano, 14, 6, 6729-6742 ACS Nano, 14, 6, 6729-6742 2020/06/23 研究論文(学術雑誌) 公開
Kentaro Fujiwara, Hiroki Akiba, Atsushi B. Tsuji, Hitomi Sudo, Aya Sugyo, Kotaro Nagatsu, Ming-Rong Zhang, Hiroko Iwanari, Osamu Kusano-Arai, Shota Kudo, Chika Kikuchi, Kouhei Tsumoto, Toshimitsu Momose, Takao Hamakubo, Tatsuya Higashi Kentaro Fujiwara, Hiroki Akiba, Atsushi B. Tsuji, Hitomi Sudo, Aya Sugyo, Kotaro Nagatsu, Ming-Rong Zhang, Hiroko Iwanari, Osamu Kusano-Arai, Shota Kudo, Chika Kikuchi, Kouhei Tsumoto, Toshimitsu Momose, Takao Hamakubo, Tatsuya Higashi Kentaro Fujiwara, Hiroki Akiba, Atsushi B. Tsuji, Hitomi Sudo, Aya Sugyo, Kotaro Nagatsu, Ming-Rong Zhang, Hiroko Iwanari, Osamu Kusano-Arai, Shota Kudo, Chika Kikuchi, Kouhei Tsumoto, Toshimitsu Momose, Takao Hamakubo, Tatsuya Higashi 64Cu-labeled minibody D2101 visualizes CDH17-positive gastric cancer xenografts with short waiting time 64Cu-labeled minibody D2101 visualizes CDH17-positive gastric cancer xenografts with short waiting time 64Cu-labeled minibody D2101 visualizes CDH17-positive gastric cancer xenografts with short waiting time Nuclear Medicine Communications, 41, 7, 688-695 Nuclear Medicine Communications, 41, 7, 688-695 Nuclear Medicine Communications, 41, 7, 688-695 2020/05/01 研究論文(学術雑誌) 公開
Daiki Kato, Tomonori Yaguchi, Takashi Iwata, Yuki Katoh, Kenji Morii, Kinya Tsubota, Yoshiaki Takise, Masaki Tamiya, Haruhiko Kamada, Hiroki Akiba, Kouhei Tsumoto, Satoshi Serada, Tetsuji Naka, Ryohei Nishimura, Takayuki Nakagawa, Yutaka Kawakami Daiki Kato, Tomonori Yaguchi, Takashi Iwata, Yuki Katoh, Kenji Morii, Kinya Tsubota, Yoshiaki Takise, Masaki Tamiya, Haruhiko Kamada, Hiroki Akiba, Kouhei Tsumoto, Satoshi Serada, Tetsuji Naka, Ryohei Nishimura, Takayuki Nakagawa, Yutaka Kawakami Daiki Kato, Tomonori Yaguchi, Takashi Iwata, Yuki Katoh, Kenji Morii, Kinya Tsubota, Yoshiaki Takise, Masaki Tamiya, Haruhiko Kamada, Hiroki Akiba, Kouhei Tsumoto, Satoshi Serada, Tetsuji Naka, Ryohei Nishimura, Takayuki Nakagawa, Yutaka Kawakami GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab. GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab. GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab. eLife, 9, e49392 eLife, 9, e49392 eLife, 9, e49392 2020/03/31 英語 研究論文(学術雑誌) 公開
Akiba H, Tamura H, Caaveiro JMM, Tsumoto K Akiba H, Tamura H, Caaveiro JMM, Tsumoto K Akiba H, Tamura H, Caaveiro JMM, Tsumoto K Computer-guided library generation applied to the optimization of single-domain antibodies Computer-guided library generation applied to the optimization of single-domain antibodies Computer-guided library generation applied to the optimization of single-domain antibodies Prot. Eng. Des. Selec., 32, 9, 423-431 Prot. Eng. Des. Selec., 32, 9, 423-431 Prot. Eng. Des. Selec., 32, 9, 423-431 2020/03 公開
Akiba H, Takayanagi K, Kusano-Arai O, Iwanari H, Hamakubo T, Tsumoto K Akiba H, Takayanagi K, Kusano-Arai O, Iwanari H, Hamakubo T, Tsumoto K Akiba H, Takayanagi K, Kusano-Arai O, Iwanari H, Hamakubo T, Tsumoto K Generation of biparatopic antibody through two step targeting of fragment antibodies on antigen using SpyTag and SpyCatcher Generation of biparatopic antibody through two step targeting of fragment antibodies on antigen using SpyTag and SpyCatcher Generation of biparatopic antibody through two step targeting of fragment antibodies on antigen using SpyTag and SpyCatcher Biotechnology Reports, 25, e00418 Biotechnology Reports, 25, e00418 Biotechnology Reports, 25, e00418 2020/03 英語 研究論文(学術雑誌) 公開
興野 悠太郎, 鈴木 祥平, 山﨑 昌子, 玉木 聡志, 伊原 頌二, 秋葉 宏樹, 小川 隆 興野 悠太郎, 鈴木 祥平, 山﨑 昌子, 玉木 聡志, 伊原 頌二, 秋葉 宏樹, 小川 隆 人工知能と分散協調型の実験自動化装置群を用いた、variantome型の抗体・ペプチド医薬品探索 人工知能と分散協調型の実験自動化装置群を用いた、variantome型の抗体・ペプチド医薬品探索 Variantome driven antibody/peptide design via artificial intelligence and distributed cooperative automatic experiment devices 人工知能学会誌, 35, 1, 61-63 人工知能学会誌, 35, 1, 61-63 , 35, 1, 61-63 2020/01 日本語 公開
Akiba H, Tsumoto K Akiba H, Tsumoto K Akiba H, Tsumoto K Development and activities, including immunocomplex formation, of biparatopic antibodies and alternative scaffold proteins Development and activities, including immunocomplex formation, of biparatopic antibodies and alternative scaffold proteins Development and activities, including immunocomplex formation, of biparatopic antibodies and alternative scaffold proteins Translat. Regulat. Sci., 2, 1, 1-6 Translat. Regulat. Sci., 2, 1, 1-6 Translat. Regulat. Sci., 2, 1, 1-6 2020/01 英語 研究論文(学術雑誌) 公開
Akiba H, Tamura H, Kiyoshi M, Yanaka S, Sugase K, Caaveiro JMM, Tsumoto K Akiba H, Tamura H, Kiyoshi M, Yanaka S, Sugase K, Caaveiro JMM, Tsumoto K Akiba H, Tamura H, Kiyoshi M, Yanaka S, Sugase K, Caaveiro JMM, Tsumoto K Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody. Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody. Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody. Scientific reports, 9, 1, 15481 Scientific reports, 9, 1, 15481 Scientific reports, 9, 1, 15481 2019/10 公開
Fujiwara K, Tsuji AB, Sudo H, Sugyo A, Akiba H, Iwanari H, Kusano-Arai O, Tsumoto K, Momose T, Hamakubo T, Higashi T Fujiwara K, Tsuji AB, Sudo H, Sugyo A, Akiba H, Iwanari H, Kusano-Arai O, Tsumoto K, Momose T, Hamakubo T, Higashi T Fujiwara K, Tsuji AB, Sudo H, Sugyo A, Akiba H, Iwanari H, Kusano-Arai O, Tsumoto K, Momose T, Hamakubo T, Higashi T <sup>111</sup>In-labeled anti-cadherin17 antibody D2101 has potential as a noninvasive imaging probe for diagnosing gastric cancer and lymph-node metastasis. <sup>111</sup>In-labeled anti-cadherin17 antibody D2101 has potential as a noninvasive imaging probe for diagnosing gastric cancer and lymph-node metastasis. <sup>111</sup>In-labeled anti-cadherin17 antibody D2101 has potential as a noninvasive imaging probe for diagnosing gastric cancer and lymph-node metastasis. Annals of nuclear medicine, 34, 13-23 Annals of nuclear medicine, 34, 13-23 Annals of nuclear medicine, 34, 13-23 2019/10 公開
Akiba H, Satoh R, Nagata S, Tsumoto K Akiba H, Satoh R, Nagata S, Tsumoto K Akiba H, Satoh R, Nagata S, Tsumoto K Effect of allotypic variation of human IgG1 on the thermal stability of disulfide-linked knobs-into-holes mutants of the Fc for stable bispecific antibody design Effect of allotypic variation of human IgG1 on the thermal stability of disulfide-linked knobs-into-holes mutants of the Fc for stable bispecific antibody design Effect of allotypic variation of human IgG1 on the thermal stability of disulfide-linked knobs-into-holes mutants of the Fc for stable bispecific antibody design Antibody Therapeutics, 2, 2, 65-69 Antibody Therapeutics, 2, 2, 65-69 Antibody Therapeutics, 2, 2, 65-69 2019/09 英語 研究論文(学術雑誌) 公開
Akiba H, Ikeuchi E, Ganbat J, Fujikawa H, Arai-Kusano O, Iwanari H, Nakakido M, Hamakubo T, Shimomura Y, Tsumoto K Akiba H, Ikeuchi E, Ganbat J, Fujikawa H, Arai-Kusano O, Iwanari H, Nakakido M, Hamakubo T, Shimomura Y, Tsumoto K Akiba H, Ikeuchi E, Ganbat J, Fujikawa H, Arai-Kusano O, Iwanari H, Nakakido M, Hamakubo T, Shimomura Y, Tsumoto K Structural behavior of keratin-associated protein 8.1 in human hair as revealed by a monoclonal antibody. Structural behavior of keratin-associated protein 8.1 in human hair as revealed by a monoclonal antibody. Structural behavior of keratin-associated protein 8.1 in human hair as revealed by a monoclonal antibody. Journal of structural biology, 204, 2, 207-214 Journal of structural biology, 204, 2, 207-214 Journal of structural biology, 204, 2, 207-214 2018/08 公開
Kazuhiro Miyanabe, Hiroki Akiba, Daisuke Kuroda, Makoto Nakakido, Osamu Kusano-Arai, Hiroko Iwanari, Takao Hamakubo, Jose M M Caaveiro, Kouhei Tsumoto Kazuhiro Miyanabe, Hiroki Akiba, Daisuke Kuroda, Makoto Nakakido, Osamu Kusano-Arai, Hiroko Iwanari, Takao Hamakubo, Jose M M Caaveiro, Kouhei Tsumoto Kazuhiro Miyanabe, Hiroki Akiba, Daisuke Kuroda, Makoto Nakakido, Osamu Kusano-Arai, Hiroko Iwanari, Takao Hamakubo, Jose M M Caaveiro, Kouhei Tsumoto Intramolecular H-bonds govern the recognition of a flexible peptide by an antibody. Intramolecular H-bonds govern the recognition of a flexible peptide by an antibody. Intramolecular H-bonds govern the recognition of a flexible peptide by an antibody. Journal of biochemistry, 164, 1, 65-76 Journal of biochemistry, 164, 1, 65-76 Journal of biochemistry, 164, 1, 65-76 2018/07/01 英語 研究論文(学術雑誌) 公開
Miyanabe K, Yamashita T, Abe Y, Akiba H, Takamatsu Y, Nakakido M, Hamakubo T, Ueda T, Caaveiro JMM, Tsumoto K Miyanabe K, Yamashita T, Abe Y, Akiba H, Takamatsu Y, Nakakido M, Hamakubo T, Ueda T, Caaveiro JMM, Tsumoto K Miyanabe K, Yamashita T, Abe Y, Akiba H, Takamatsu Y, Nakakido M, Hamakubo T, Ueda T, Caaveiro JMM, Tsumoto K Tyrosine Sulfation Restricts the Conformational Ensemble of a Flexible Peptide, Strengthening the Binding Affinity for an Antibody. Tyrosine Sulfation Restricts the Conformational Ensemble of a Flexible Peptide, Strengthening the Binding Affinity for an Antibody. Tyrosine Sulfation Restricts the Conformational Ensemble of a Flexible Peptide, Strengthening the Binding Affinity for an Antibody. Biochemistry, 57, 28, 4177-4185 Biochemistry, 57, 28, 4177-4185 Biochemistry, 57, 28, 4177-4185 2018/07 公開
Kawade R, Akiba H, Entzminger K, Maruyama T, Okumura CJ, Tsumoto K Kawade R, Akiba H, Entzminger K, Maruyama T, Okumura CJ, Tsumoto K Kawade R, Akiba H, Entzminger K, Maruyama T, Okumura CJ, Tsumoto K Roles of the disulfide bond between the variable and the constant domains of rabbit immunoglobulin kappa chains in thermal stability and affinity. Roles of the disulfide bond between the variable and the constant domains of rabbit immunoglobulin kappa chains in thermal stability and affinity. Roles of the disulfide bond between the variable and the constant domains of rabbit immunoglobulin kappa chains in thermal stability and affinity. Protein engineering, design & selection : PEDS, 31, 7-8, 243-247 Protein engineering, design & selection : PEDS, 31, 7-8, 243-247 Protein engineering, design & selection : PEDS, 31, 7-8, 243-247 2018/05 公開
Osamu Kusano-Arai, Hiroko Iwanari, Shota Kudo, Chika Kikuchi, Anna Yui, Hiroki Akiba, Keisuke Matsusaka, Atsushi Kaneda, Masashi Fukayama, Kouhei Tsumoto, Takao Hamakubo Osamu Kusano-Arai, Hiroko Iwanari, Shota Kudo, Chika Kikuchi, Anna Yui, Hiroki Akiba, Keisuke Matsusaka, Atsushi Kaneda, Masashi Fukayama, Kouhei Tsumoto, Takao Hamakubo Osamu Kusano-Arai, Hiroko Iwanari, Shota Kudo, Chika Kikuchi, Anna Yui, Hiroki Akiba, Keisuke Matsusaka, Atsushi Kaneda, Masashi Fukayama, Kouhei Tsumoto, Takao Hamakubo Synergistic Cytotoxic Effect on Gastric Cancer Cells of an Immunotoxin Cocktail in Which Antibodies Recognize Different Epitopes on CDH17 Synergistic Cytotoxic Effect on Gastric Cancer Cells of an Immunotoxin Cocktail in Which Antibodies Recognize Different Epitopes on CDH17 Synergistic Cytotoxic Effect on Gastric Cancer Cells of an Immunotoxin Cocktail in Which Antibodies Recognize Different Epitopes on CDH17 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 37, 1, 1-11 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 37, 1, 1-11 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 37, 1, 1-11 2018/02 研究論文(学術雑誌) 公開
Anna Yui, Hiroki Akiba, Shota Kudo, Makoto Nakakido, Satoru Nagatoishi, Kouhei Tsumoto Anna Yui, Hiroki Akiba, Shota Kudo, Makoto Nakakido, Satoru Nagatoishi, Kouhei Tsumoto Anna Yui, Hiroki Akiba, Shota Kudo, Makoto Nakakido, Satoru Nagatoishi, Kouhei Tsumoto Thermodynamic analyses of amino acid residues at the interface of an antibody B2212A and its antigen roundabout homolog 1 Thermodynamic analyses of amino acid residues at the interface of an antibody B2212A and its antigen roundabout homolog 1 Thermodynamic analyses of amino acid residues at the interface of an antibody B2212A and its antigen roundabout homolog 1 JOURNAL OF BIOCHEMISTRY, 162, 4, 255-258 JOURNAL OF BIOCHEMISTRY, 162, 4, 255-258 JOURNAL OF BIOCHEMISTRY, 162, 4, 255-258 2017/10 英語 研究論文(学術雑誌) 公開
Kyohei Yumura, Hiroki Akiba, Satoru Nagatoishi, Osamu Kusano-Arai, Hiroko Iwanari, Takao Hamakubo, Kouhei Tsumoto Kyohei Yumura, Hiroki Akiba, Satoru Nagatoishi, Osamu Kusano-Arai, Hiroko Iwanari, Takao Hamakubo, Kouhei Tsumoto Kyohei Yumura, Hiroki Akiba, Satoru Nagatoishi, Osamu Kusano-Arai, Hiroko Iwanari, Takao Hamakubo, Kouhei Tsumoto Use of SpyTag/SpyCatcher to construct bispecific antibodies that target two epitopes of a single antigen Use of SpyTag/SpyCatcher to construct bispecific antibodies that target two epitopes of a single antigen Use of SpyTag/SpyCatcher to construct bispecific antibodies that target two epitopes of a single antigen JOURNAL OF BIOCHEMISTRY, 162, 3, 203-210 JOURNAL OF BIOCHEMISTRY, 162, 3, 203-210 JOURNAL OF BIOCHEMISTRY, 162, 3, 203-210 2017/09 英語 研究論文(学術雑誌) 公開
Perche F, Uchida S, Akiba H, Lin CY, Ikegami M, Dirisala A, Nakashima T, Itaka K, Tsumoto K, Kataoka K Perche F, Uchida S, Akiba H, Lin CY, Ikegami M, Dirisala A, Nakashima T, Itaka K, Tsumoto K, Kataoka K Federico Perche, Satoshi Uchida, Hiroki Akiba, Chin-Yu Lin, Masaru Ikegami, Anjaneyulu Dirisala, Toshihiro Nakashima, Keiji Itaka, Kohei Tsumoto, Kazunori Kataoka Improved Brain Expression of Anti-Amyloid β scFv by Complexation of mRNA Including a Secretion Sequence with PEG-based Block Catiomer. Improved Brain Expression of Anti-Amyloid β scFv by Complexation of mRNA Including a Secretion Sequence with PEG-based Block Catiomer. Improved Brain Expression of Anti-Amyloid beta scFv by Complexation of mRNA Including a Secretion Sequence with PEG-based Block Catiomer Current Alzheimer research, 14, 3, 295-302 Current Alzheimer research, 14, 3, 295-302 CURRENT ALZHEIMER RESEARCH, 14, 3, 295-302 2017 英語 研究論文(学術雑誌) 公開
秋葉宏樹, 津本浩平 秋葉宏樹, 津本浩平 抗体の小分子化とドラッグデリバリーへの展開 抗体の小分子化とドラッグデリバリーへの展開 月刊バイオインダストリー, 33, 2, 47-53 月刊バイオインダストリー, 33, 2, 47-53 , 33, 2, 47-53 2016 日本語 公開
Jun Sumaoka, Hiroki Akiba, Makoto Komiyama Jun Sumaoka, Hiroki Akiba, Makoto Komiyama Jun Sumaoka, Hiroki Akiba, Makoto Komiyama Selective Sensing of Tyrosine Phosphorylation in Peptides Using Terbium(III) Complexes Selective Sensing of Tyrosine Phosphorylation in Peptides Using Terbium(III) Complexes Selective Sensing of Tyrosine Phosphorylation in Peptides Using Terbium(III) Complexes INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY, 2016, 3216523 INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY, 2016, 3216523 INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY, 2016, 3216523 2016 英語 公開
Hiroki Akiba, Kouhei Tsumoto Hiroki Akiba, Kouhei Tsumoto Hiroki Akiba, Kouhei Tsumoto Thermodynamics of antibody-antigen interaction revealed by mutation analysis of antibody variable regions Thermodynamics of antibody-antigen interaction revealed by mutation analysis of antibody variable regions Thermodynamics of antibody-antigen interaction revealed by mutation analysis of antibody variable regions JOURNAL OF BIOCHEMISTRY, 158, 1, 1-13 JOURNAL OF BIOCHEMISTRY, 158, 1, 1-13 JOURNAL OF BIOCHEMISTRY, 158, 1, 1-13 2015/07 英語 公開
Hiroki Akiba, Jun Sumaoka, Kouhei Tsumoto, Makoto Komiyama Hiroki Akiba, Jun Sumaoka, Kouhei Tsumoto, Makoto Komiyama Hiroki Akiba, Jun Sumaoka, Kouhei Tsumoto, Makoto Komiyama Click Conjugation of a Binuclear Terbium(III) Complex for Real-Time Detection of Tyrosine Phosphorylation Click Conjugation of a Binuclear Terbium(III) Complex for Real-Time Detection of Tyrosine Phosphorylation Click Conjugation of a Binuclear Terbium(III) Complex for Real-Time Detection of Tyrosine Phosphorylation ANALYTICAL CHEMISTRY, 87, 7, 3834-3840 ANALYTICAL CHEMISTRY, 87, 7, 3834-3840 ANALYTICAL CHEMISTRY, 87, 7, 3834-3840 2015/04 英語 研究論文(学術雑誌) 公開
Hiroki Akiba, Jun Sumaoka, Takao Hamakubo, Makoto Komiyama Hiroki Akiba, Jun Sumaoka, Takao Hamakubo, Makoto Komiyama Hiroki Akiba, Jun Sumaoka, Takao Hamakubo, Makoto Komiyama Conjugation-free, visual, and quantitative evaluation of inhibitors on protein tyrosine kinases and phosphatases with a luminescent Tb(III) complex Conjugation-free, visual, and quantitative evaluation of inhibitors on protein tyrosine kinases and phosphatases with a luminescent Tb(III) complex Conjugation-free, visual, and quantitative evaluation of inhibitors on protein tyrosine kinases and phosphatases with a luminescent Tb(III) complex ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 406, 12, 2957-2964 ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 406, 12, 2957-2964 ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 406, 12, 2957-2964 2014/05 英語 研究論文(学術雑誌) 公開
Hiroki Akiba, Jun Sumaoka, Makoto Komiyama Hiroki Akiba, Jun Sumaoka, Makoto Komiyama Hiroki Akiba, Jun Sumaoka, Makoto Komiyama Binuclear Terbium(III) Complex as a Probe for Tyrosine Phosphorylation Binuclear Terbium(III) Complex as a Probe for Tyrosine Phosphorylation Binuclear Terbium(III) Complex as a Probe for Tyrosine Phosphorylation CHEMISTRY-A EUROPEAN JOURNAL, 16, 17, 5018-5025 CHEMISTRY-A EUROPEAN JOURNAL, 16, 17, 5018-5025 CHEMISTRY-A EUROPEAN JOURNAL, 16, 17, 5018-5025 2010 英語 研究論文(学術雑誌) 公開
Hiroki Akiba, Jun Sumaoka, Makoto Komiyama Hiroki Akiba, Jun Sumaoka, Makoto Komiyama Hiroki Akiba, Jun Sumaoka, Makoto Komiyama Selective Detection of Phosphotyrosine in the Presence of Various Phosphate-Containing Biomolecules with the Aid of a Terbium(III) Complex Selective Detection of Phosphotyrosine in the Presence of Various Phosphate-Containing Biomolecules with the Aid of a Terbium(III) Complex Selective Detection of Phosphotyrosine in the Presence of Various Phosphate-Containing Biomolecules with the Aid of a Terbium(III) Complex CHEMBIOCHEM, 10, 11, 1773-1776 CHEMBIOCHEM, 10, 11, 1773-1776 CHEMBIOCHEM, 10, 11, 1773-1776 2009/07 英語 研究論文(学術雑誌) 公開

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講演・口頭発表等
タイトル タイトル(日本語) タイトル(英語) 会議名 会議名(日本語) 会議名(英語) 主催者 主催者(日本語) 主催者(英語) 発表年月日 記述言語 会議種別 公開
抗体エピトープの特徴付けとバイパラトピック抗体への展開[招待あり] 抗体エピトープの特徴付けとバイパラトピック抗体への展開 [招待あり] バイオインタラクション研究会 第 11 回ワークショップ バイオインタラクション研究会 第 11 回ワークショップ 2020/11/24 公開
タイトル言語:
外部資金:競争的資金 (科学研究費補助金以外)
制度名 代表者名 研究課題(日本語) 研究課題(英語) 期間
京都発革新的医療技術研究開発助成事業 秋葉 宏樹 抗体医薬の低分子化と機能化を同時に実現する化学的技術の開発 (2020年度分) 2020/04/01〜2021/03/31
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
実践創薬科学実習 Laboratory Practice in Practical Drug Discovery Science 通年不定 薬学研究科 2021/04〜2022/03
実践創薬科学実験 Research in Practical Drug Discovery Science 通年不定 薬学研究科 2021/04〜2022/03
実践創薬科学演習 Practical Drug Discovery Science Seminar 通年不定 薬学研究科 2021/04〜2022/03
薬学専門実習IV 【H30以降入学者用】 Pharmaceutical Laboratory IV : Biochemistry and Microbiology 後期 薬学部 2021/04〜2022/03
薬学専門実習4 Pharmaceutical Laboratory 4 : Biochemistry and Microbiology 後期 薬学部 2021/04〜2022/03