小林稔

最終更新日時: 2019/06/28 12:06:02

氏名(漢字／フリガナ／アルファベット表記)

小林稔／コバヤシミノル／Kobayashi, Minoru

所属部署・職名(部局／所属／講座等／職名)

生命科学研究科／高次生命科学専攻ゲノム生物学講座／特定助教

取得学位

学位名(日本語)	学位名(英語)	大学(日本語)	大学(英語)	取得区分
修士（医学）		北海道大学
博士（医学）		北海道大学

出身大学院・研究科等

大学名(日本語)	大学名(英語)	研究科名(日本語)	研究科名(英語)	専攻名(日本語)	専攻名(英語)	修了区分
北海道大学		大学院医学研究科医学専攻修士課程				修了
北海道大学		大学院医学研究科医学専攻博士課程				修了

出身学校・専攻等

大学名(日本語)	大学名(英語)	学部名(日本語)	学部名(英語)	学科名(日本語)	学科名(英語)	卒業区分
北海道大学		理学部生物科学科				卒業

出身高等学校

高等学校名	ふりがな
智辯学園和歌山	ちべんがくえんわかやま

researchmap URL

https://researchmap.jp/7000009889

研究テーマ

(日本語)
生体の低酸素応答を担う作用機序と生理的機能の解明
(英語)
Analysis for the regulatory mechanisms and physiological importance of hypoxia response

研究概要

(日本語)
生体内の環境は極めて多様で、各細胞は周囲の微小環境に適応しながら形態と機能を維持している。それらの微小環境の中で、低酸素は発生や幹細胞性質の維持、がんの悪性化などに関わることが示唆されている。当研究室では、細胞の低酸素応答マスターレギュレーターとして知られるHIFを中心に細胞の低酸素応答の制御メカニズムやその生理的機能の解明を目指し研究を行っている。
(英語)
The environment is extremely diverse in vivo, and each cell maintains itself while adapting to the surrounding microenvironment. In those microenvironment, hypoxia regulates many physiological functions. In our laboratory, the we focus on HIF which is known as master regulator of cellular hypoxic responses and analyze the regulatory mechanisms and physiological importance of hypoxia response.

研究分野（キーワード）

キーワード(日本語)	キーワード(英語)
低酸素	hypoxia
HIF	HIF
分子細胞生物学	molecular cell biology
腫瘍	cancer
発生	development

論文

著者	著者(日本語)	著者(英語)	タイトル	タイトル(日本語)	タイトル(英語)	書誌情報等	書誌情報等(日本語)	書誌情報等(英語)	出版年月	査読の有無	記述言語	掲載種別	公開
Nagao A, Kobayashi M, Koyasu S, Chow CCT, Harada H	Nagao A, Kobayashi M, Koyasu S, Chow CCT, Harada H	Nagao A, Kobayashi M, Koyasu S, Chow CCT, Harada H	HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance.	HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance.	HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance.	International journal of molecular sciences, 20, 2	International journal of molecular sciences, 20, 2	International journal of molecular sciences, 20, 2	2019/01	有			公開
Koyasu S, Kobayashi M, Goto Y, Hiraoka M, Harada H	Koyasu S, Kobayashi M, Goto Y, Hiraoka M, Harada H	Koyasu S, Kobayashi M, Goto Y, Hiraoka M, Harada H	Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge.	Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge.	Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge.	Cancer science, 109, 3, 560-571	Cancer science, 109, 3, 560-571	Cancer science, 109, 3, 560-571	2018/03	有			公開
Katagiri T, Kobayashi M, Yoshimura M, Morinibu A, Itasaka S, Hiraoka M, Harada H	Katagiri T, Kobayashi M, Yoshimura M, Morinibu A, Itasaka S, Hiraoka M, Harada H	Katagiri T, Kobayashi M, Yoshimura M, Morinibu A, Itasaka S, Hiraoka M, Harada H	HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic hedgehog.	HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic hedgehog.	HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic hedgehog.	Oncotarget, 9, 12, 10525-10535	Oncotarget, 9, 12, 10525-10535	Oncotarget, 9, 12, 10525-10535	2018/02	有			公開
Kobayashi M, Morinibu A, Koyasu S, Goto Y, Hiraoka M, Harada H	Kobayashi M, Morinibu A, Koyasu S, Goto Y, Hiraoka M, Harada H	Kobayashi M, Morinibu A, Koyasu S, Goto Y, Hiraoka M, Harada H	A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes.	A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes.	A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes.	The FEBS journal, 284, 22, 3804-3816	The FEBS journal, 284, 22, 3804-3816	The FEBS journal, 284, 22, 3804-3816	2017/11	有			公開
Goto Y, Koyasu S, Kobayashi M, Harada H	Goto Y, Koyasu S, Kobayashi M, Harada H	Goto Y, Koyasu S, Kobayashi M, Harada H	The emerging roles of the ubiquitination/deubiquitination system in tumor radioresistance regarding DNA damage responses, cell cycle regulation, hypoxic responses, and antioxidant properties: Insight into the development of novel radiosensitizing strategi	The emerging roles of the ubiquitination/deubiquitination system in tumor radioresistance regarding DNA damage responses, cell cycle regulation, hypoxic responses, and antioxidant properties: Insight into the development of novel radiosensitizing strategi	The emerging roles of the ubiquitination/deubiquitination system in tumor radioresistance regarding DNA damage responses, cell cycle regulation, hypoxic responses, and antioxidant properties: Insight into the development of novel radiosensitizing strategi	Mutation research, 803-805, 76-81	Mutation research, 803-805, 76-81	Mutation research, 803-805, 76-81	2017/10	有			公開
Nakashima R, Goto Y, Koyasu S, Kobayashi M, Morinibu A, Yoshimura M, Hiraoka M, Hammond EM, Harada H	Nakashima R, Goto Y, Koyasu S, Kobayashi M, Morinibu A, Yoshimura M, Hiraoka M, Hammond EM, Harada H	Nakashima R, Goto Y, Koyasu S, Kobayashi M, Morinibu A, Yoshimura M, Hiraoka M, Hammond EM, Harada H	UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization.	UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization.	UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization.	Scientific reports, 7, 1, 6879	Scientific reports, 7, 1, 6879	Scientific reports, 7, 1, 6879	2017/07	有			公開
Yeom CJ, Zeng L, Goto Y, Morinibu A, Zhu Y, Shinomiya K, Kobayashi M, Itasaka S, Yoshimura M, Hur CG, Kakeya H, Hammond EM, Hiraoka M, Harada H	Yeom CJ, Zeng L, Goto Y, Morinibu A, Zhu Y, Shinomiya K, Kobayashi M, Itasaka S, Yoshimura M, Hur CG, Kakeya H, Hammond EM, Hiraoka M, Harada H	Yeom CJ, Zeng L, Goto Y, Morinibu A, Zhu Y, Shinomiya K, Kobayashi M, Itasaka S, Yoshimura M, Hur CG, Kakeya H, Hammond EM, Hiraoka M, Harada H	LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis.	LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis.	LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis.	Oncotarget, 7, 40, 65837-65848	Oncotarget, 7, 40, 65837-65848	Oncotarget, 7, 40, 65837-65848	2016/10	有			公開
Inoue M, Yoshimura M, Kobayashi M, Morinibu A, Itasaka S, Hiraoka M, Harada H	Inoue M, Yoshimura M, Kobayashi M, Morinibu A, Itasaka S, Hiraoka M, Harada H	Inoue M, Yoshimura M, Kobayashi M, Morinibu A, Itasaka S, Hiraoka M, Harada H	PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase.	PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase.	PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase.	Scientific reports, 5, 15666	Scientific reports, 5, 15666	Scientific reports, 5, 15666	2015/10	有			公開
Goto Y, Zeng L, Yeom CJ, Zhu Y, Morinibu A, Shinomiya K, Kobayashi M, Hirota K, Itasaka S, Yoshimura M, Tanimoto K, Torii M, Sowa T, Menju T, Sonobe M, Kakeya H, Toi M, Date H, Hammond EM, Hiraoka M, Harada H	Goto Y, Zeng L, Yeom CJ, Zhu Y, Morinibu A, Shinomiya K, Kobayashi M, Hirota K, Itasaka S, Yoshimura M, Tanimoto K, Torii M, Sowa T, Menju T, Sonobe M, Kakeya H, Toi M, Date H, Hammond EM, Hiraoka M, Harada H	Yoko Goto, Lihua Zeng, ChanJoo Yeom, Yuxi Zhu, Akiyo Morinibu, Kazumi Shinomiya, Minoru Kobayashi, Kiichi Hirota, Satoshi Itasaka, Michio Yoshimura, Keiji Tanimoto, Masae Torii, Terumasa Sowa, Tosih Menju, Makoto Sonobe, Hideaki Kakeya, Masakazu Toi, Hiroshi Date, Ester M. Hammond, Masahiro Hiraoka, Hiroshi Harada	UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.	UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.	UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.	Nature Communications., 23, 6, 6153	Nature Communications., 23, 6, 6153	Nature Communications., 23, 6, 6153	2015/01	有	英語	研究論文(学術雑誌)	公開
Lihua Zeng, Akiyo Morinibu, Minoru Kobayashi, Yuxi Zhu, Xiaowu Wang, Yoko Goto, ChanJoo Yeom, Tao Zhao, Kiichi Hirota, Kazumi Shinomiya, Satoshi Itasaka, Yoshimura M, Guo G, Hammond EM, Masahiro Hiraoka, Hiroshi Harada		Lihua Zeng, Akiyo Morinibu, Minoru Kobayashi, Yuxi Zhu, Xiaowu Wang, Yoko Goto, ChanJoo Yeom, Tao Zhao, Kiichi Hirota, Kazumi Shinomiya, Satoshi Itasaka, Yoshimura M, Guo G, Hammond EM, Masahiro Hiraoka, Hiroshi Harada	Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis.	Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis.	Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis.	Oncogene.	Oncogene.	Oncogene.	2014/12	有	英語	研究論文(学術雑誌)	公開
Zhao T, Zhu Y, Morinibu A, Kobayashi M, Shinomiya K, Itasaka S, Yoshimura M, Guo G, Hiraoka M, Harada H	Zhao T, Zhu Y, Morinibu A, Kobayashi M, Shinomiya K, Itasaka S, Yoshimura M, Guo G, Hiraoka M, Harada H	Tao Zhao, Yuxi Zhu, Akiyo Morinibu, Minoru Kobayashi, Kazumi Shinomiya, Satoshi Itasaka, Michio Yoshimura,Guozheng Guo, Masahiro Hiraoka, Hiroshi Harada.	HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs.	HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs.	HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs.	Scientific Reports., 23, 4, 3793	Scientific Reports., 23, 4, 3793	Scientific Reports., 23, 4, 3793	2014/01	有	英語	研究論文(学術雑誌)	公開
小林　稔. 原田　浩	小林　稔. 原田　浩		低酸素ストレスとHIF	低酸素ストレスとHIF		生化学, 85, 187	生化学, 85, 187	, 85, 187	2013	有	日本語		公開
Minoru Kobayashi, Shigeru Ashino, Yasuo Shiohama, Daiko Wakita, Hidemitsu Kitamura, Takashi Nishimura.		Minoru Kobayashi, Shigeru Ashino, Yasuo Shiohama, Daiko Wakita, Hidemitsu Kitamura, Takashi Nishimura.	IFN-gamma elevates airway hyperresponsiveness via upregulation of neurokinin A/neurokinin-2 receptor signaling in a severe asthma model.	IFN-gamma elevates airway hyperresponsiveness via upregulation of neurokinin A/neurokinin-2 receptor signaling in a severe asthma model.	IFN-gamma elevates airway hyperresponsiveness via upregulation of neurokinin A/neurokinin-2 receptor signaling in a severe asthma model.	European Journal of Immunology, 42, 2, 393-342	European Journal of Immunology, 42, 2, 393-342	European Journal of Immunology, 42, 2, 393-342	2012	有	英語	研究論文(学術雑誌)	公開
Hidemitsu Kitamura, Minoru Kobayashi, Daiko Wakita, Takashi Nishimura		Hidemitsu Kitamura, Minoru Kobayashi, Daiko Wakita, Takashi Nishimura	Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor.	Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor.	Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor.	The Journal of Immunology., 188, 9, 4200-4208	The Journal of Immunology., 188, 9, 4200-4208	The Journal of Immunology., 188, 9, 4200-4208	2012	有	英語	研究論文(学術雑誌)	公開
西村　孝司. 小林　稔. 脇田　大功. 北村　秀光. 芦野　茂.	西村　孝司. 小林　稔. 脇田　大功. 北村　秀光. 芦野　茂.		Th17細胞による気道過敏反応の増強とその機序: Th1/Th2細胞依存的気道炎症との異同	Th17細胞による気道過敏反応の増強とその機序: Th1/Th2細胞依存的気道炎症との異同		臨床免疫・アレルギー科, 54, 631-638	臨床免疫・アレルギー科, 54, 631-638	, 54, 631-638	2010	有	日本語		公開
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Misc

著者	著者(日本語)	著者(英語)	タイトル	タイトル(日本語)	タイトル(英語)	出版年月	記述言語	掲載種別	公開
小林稔	小林稔	Minoru Kobayashi, Hiraoka Masahiro, Harada Hiroshi	Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels	Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels	Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels	2015	英語	総説・解説(国際会議プロシーディングス)	公開
小林　稔. 平岡真寛. 原田浩	小林　稔. 平岡真寛. 原田浩		時計遺伝子PER2と低酸素応答機構の相互作用メカニズムの解析	時計遺伝子PER2と低酸素応答機構の相互作用メカニズムの解析		2014	日本語	研究発表要旨(全国大会、その他学術会議)	公開
Minoru Kobayashi, Masahiro Hiraoka, Hiroshi Harada		Minoru Kobayashi, Masahiro Hiraoka, Hiroshi Harada	Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels	Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels	Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels	2014	英語	総説・解説(国際会議プロシーディングス)	公開
小林　稔. 脇田　大功. 岩淵禎弘. 佐藤崇之. 北村秀光. 西村孝司	小林　稔. 脇田　大功. 岩淵禎弘. 佐藤崇之. 北村秀光. 西村孝司		Method for establishment of cancer stem-like cells by introduction of oncogenes into mesenchymal stem cells	Method for establishment of cancer stem-like cells by introduction of oncogenes into mesenchymal stem cells	Method for establishment of cancer stem-like cells by introduction of oncogenes into mesenchymal stem cells	2013	日本語	研究発表要旨(全国大会、その他学術会議)	公開
小林　稔. 曽麗華. 後藤容子. 井上実. 板坂聡. 吉村通央. 原田浩. 平岡真寛	小林　稔. 曽麗華. 後藤容子. 井上実. 板坂聡. 吉村通央. 原田浩. 平岡真寛		IDH3はHIF-1alphaを安定化して腫瘍増殖を亢進する	IDH3はHIF-1alphaを安定化して腫瘍増殖を亢進する		2013	日本語	研究発表要旨(全国大会、その他学術会議)	公開
KOBAYASHI Minoru, ASHINO Shigeru, SUZUKI Ikurou, KITAMURA Hidemitsu, YASUDA Kenji, NISHIMURA Takashi		KOBAYASHI Minoru, ASHINO Shigeru, SUZUKI Ikurou, KITAMURA Hidemitsu, YASUDA Kenji, NISHIMURA Takashi	Establishment of airway smooth muscle cell line useful for evaluating neuro-immuno cross-talk in Th1-mediated airway inflammation.	Establishment of airway smooth muscle cell line useful for evaluating neuro-immuno cross-talk in Th1-mediated airway inflammation.	Establishment of airway smooth muscle cell line useful for evaluating neuro-immuno cross-talk in Th1-mediated airway inflammation.	2011	日本語	研究発表要旨(全国大会、その他学術会議)	公開
Minoru Kobayashi, Shigeru Ashino, Hidemitsu Kitamura, Takashi Nishimura		Minoru Kobayashi, Shigeru Ashino, Hidemitsu Kitamura, Takashi Nishimura	The pivotal role of IFN-gamma in Th1- and Th17-mediated steroid-resistant airway hyperresponsiveness.	The pivotal role of IFN-gamma in Th1- and Th17-mediated steroid-resistant airway hyperresponsiveness.	The pivotal role of IFN-gamma in Th1- and Th17-mediated steroid-resistant airway hyperresponsiveness.	2010	英語	総説・解説(国際会議プロシーディングス)	公開
タイトル言語:

外部資金：競争的資金・科学研究費補助金

種別	代表/分担	テーマ(日本語)	期間
若手研究（Ｂ）	代表	低酸素・概日周期・代謝制御の相互作用による腫瘍の悪性化と放射線抵抗性機構の解明	2013〜2014
若手研究（Ｂ）	代表	低酸素・概日周期・代謝制御の相互作用による腫瘍の悪性化と放射線抵抗性機構の解明（平成26年度分）	2014/04/01〜2015/03/31
挑戦的萌芽研究	代表	レンチウィルスライブラリーを用いた放射線抵抗性に関わる因子の探索	2017/04/01〜2019/03/31
若手研究	代表	腫瘍内低酸素がん細胞ダイナミクスとHIF-1をターゲットとした新規治療法作製	2018/04/01〜2020/03/31

小林 稔

小林稔