島村 達郎

最終更新日時: 2021/01/08 13:23:48

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氏名(漢字／フリガナ／アルファベット表記)
島村 達郎／シマムラ タツロウ／Shimamura, Tatsuro
所属部署・職名(部局／所属／講座等／職名)
医学研究科／医学専攻分子生体統御学講座分子細胞情報学／特定講師
所属学会(国内)
学会名(日本語) 学会名(英語)
日本生化学会
日本農芸化学会
日本蛋白質科学会
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士（農学） 東京大学
博士（農学） 東京大学
researchmap URL
https://researchmap.jp/7000009120
研究テーマ
(日本語)
膜タンパク質の構造生物学
(英語)
Structural studies of membrane proteins
研究概要
(日本語)
タンパク質は、生体の多様な機能を支える重要な働きを担っている。このようなタンパク質の機能を理解するには、タンパク質の立体構造情報が必須である。私は、膜タンパク質を主な研究対象とし、その立体構造を解明するとともに、タンパク質の構造変化や、タンパク質を標的とする化合物の探索、相互作用の解明などを目指した研究を行っている。
(英語)
Proteins play important roles in various functions of the living cells. The structural information of the proteins is essential for understanding the functions of the proteins. The aims of my research include the elucidations of the 3D structure of membrane proteins and the mechanism of conformational changes of proteins as well as the structure-based design of new ligands.
研究分野（キーワード）
キーワード(日本語) キーワード(英語)
構造生物学 Structural biology
生化学 Biochemistry
分子生物学 Molecular biology
ケミカルバイオロジー Chemical biology
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Dohyun Im, Asuka Inoue, Takaaki Fujiwara, Takanori Nakane, Yasuaki Yamanaka, Tomoko Uemura, Chihiro Mori, Yuki Shiimura, Kanako Terakado Kimura, Hidetsugu Asada, Norimichi Nomura, Tomoyuki Tanaka, Ayumi Yamashita, Eriko Nango, Kensuke Tono, Francois Marie Ngako Kadji, Junken Aoki, So Iwata, Tatsuro Shimamura Dohyun Im, Asuka Inoue, Takaaki Fujiwara, Takanori Nakane, Yasuaki Yamanaka, Tomoko Uemura, Chihiro Mori, Yuki Shiimura, Kanako Terakado Kimura, Hidetsugu Asada, Norimichi Nomura, Tomoyuki Tanaka, Ayumi Yamashita, Eriko Nango, Kensuke Tono, Francois Marie Ngako Kadji, Junken Aoki, So Iwata, Tatsuro Shimamura Dohyun Im, Asuka Inoue, Takaaki Fujiwara, Takanori Nakane, Yasuaki Yamanaka, Tomoko Uemura, Chihiro Mori, Yuki Shiimura, Kanako Terakado Kimura, Hidetsugu Asada, Norimichi Nomura, Tomoyuki Tanaka, Ayumi Yamashita, Eriko Nango, Kensuke Tono, Francois Marie Ngako Kadji, Junken Aoki, So Iwata, Tatsuro Shimamura Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone. Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone. Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone. Nature communications, 11, 1, 6442-6442 Nature communications, 11, 1, 6442-6442 Nature communications, 11, 1, 6442-6442 2020/12/22 有 英語 研究論文(学術雑誌) 公開
Hidetsugu Asada, Asuka Inoue, Francois Marie Ngako Kadji, Kunio Hirata, Yuki Shiimura, Dohyun Im, Tatsuro Shimamura, Norimichi Nomura, Hiroko Iwanari, Takao Hamakubo, Osamu Kusano-Arai, Hiromi Hisano, Tomoko Uemura, Chiyo Suno, Junken Aoki, So Iwata Hidetsugu Asada, Asuka Inoue, Francois Marie Ngako Kadji, Kunio Hirata, Yuki Shiimura, Dohyun Im, Tatsuro Shimamura, Norimichi Nomura, Hiroko Iwanari, Takao Hamakubo, Osamu Kusano-Arai, Hiromi Hisano, Tomoko Uemura, Chiyo Suno, Junken Aoki, So Iwata Hidetsugu Asada, Asuka Inoue, Francois Marie Ngako Kadji, Kunio Hirata, Yuki Shiimura, Dohyun Im, Tatsuro Shimamura, Norimichi Nomura, Hiroko Iwanari, Takao Hamakubo, Osamu Kusano-Arai, Hiromi Hisano, Tomoko Uemura, Chiyo Suno, Junken Aoki, So Iwata The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone Structure Structure Structure 2019/12 有 英語 研究論文(学術雑誌) 公開
Mihoko Takenoya, Tatsuro Shimamura, Ryuji Yamanaka, Yuya Adachi, Shinsaku Ito, Yasuyuki Sasaki, Akira Nakamura, Shunsuke Yajima Mihoko Takenoya, Tatsuro Shimamura, Ryuji Yamanaka, Yuya Adachi, Shinsaku Ito, Yasuyuki Sasaki, Akira Nakamura, Shunsuke Yajima Mihoko Takenoya, Tatsuro Shimamura, Ryuji Yamanaka, Yuya Adachi, Shinsaku Ito, Yasuyuki Sasaki, Akira Nakamura, Shunsuke Yajima Structural basis for the substrate recognition of aminoglycoside 7′′-phosphotransferase-Ia from Streptomyces hygroscopicus Structural basis for the substrate recognition of aminoglycoside 7′′-phosphotransferase-Ia from Streptomyces hygroscopicus Structural basis for the substrate recognition of aminoglycoside 7′′-phosphotransferase-Ia from Streptomyces hygroscopicus Acta Crystallographica Section F Structural Biology Communications, 75, 9, 599-607 Acta Crystallographica Section F Structural Biology Communications, 75, 9, 599-607 Acta Crystallographica Section F Structural Biology Communications, 75, 9, 599-607 2019/09/01 有 英語 研究論文(学術雑誌) 公開
Kanako Terakado Kimura, Hidetsugu Asada, Asuka Inoue, Francois Marie Ngako Kadji, Dohyun Im, Chihiro Mori, Takatoshi Arakawa, Kunio Hirata, Yayoi Nomura, Norimichi Nomura, Junken Aoki, So Iwata, Tatsuro Shimamura Kanako Terakado Kimura, Hidetsugu Asada, Asuka Inoue, Francois Marie Ngako Kadji, Dohyun Im, Chihiro Mori, Takatoshi Arakawa, Kunio Hirata, Yayoi Nomura, Norimichi Nomura, Junken Aoki, So Iwata, Tatsuro Shimamura Kanako Terakado Kimura, Hidetsugu Asada, Asuka Inoue, Francois Marie Ngako Kadji, Dohyun Im, Chihiro Mori, Takatoshi Arakawa, Kunio Hirata, Yayoi Nomura, Norimichi Nomura, Junken Aoki, So Iwata, Tatsuro Shimamura Structures of the 5-HT <inf>2A</inf> receptor in complex with the antipsychotics risperidone and zotepine Structures of the 5-HT <inf>2A</inf> receptor in complex with the antipsychotics risperidone and zotepine Structures of the 5-HT <inf>2A</inf> receptor in complex with the antipsychotics risperidone and zotepine Nature Structural and Molecular Biology, 26, 2, 121-128 Nature Structural and Molecular Biology, 26, 2, 121-128 Nature Structural and Molecular Biology, 26, 2, 121-128 2019/02/01 有 英語 研究論文(学術雑誌) 公開
Shimazu Y, Tono K, Tanaka T, Yamanaka Y, Nakane T, Mori C, Terakado Kimura K, Fujiwara T, Sugahara M, Tanaka R, Doak RB, Shimamura T, Iwata S, Nango E, Yabashi M Shimazu Y, Tono K, Tanaka T, Yamanaka Y, Nakane T, Mori C, Terakado Kimura K, Fujiwara T, Sugahara M, Tanaka R, Doak RB, Shimamura T, Iwata S, Nango E, Yabashi M Shimazu Y, Tono K, Tanaka T, Yamanaka Y, Nakane T, Mori C, Terakado Kimura K, Fujiwara T, Sugahara M, Tanaka R, Doak RB, Shimamura T, Iwata S, Nango E, Yabashi M High-viscosity sample-injection device for serial femtosecond crystallography at atmospheric pressure High-viscosity sample-injection device for serial femtosecond crystallography at atmospheric pressure High-viscosity sample-injection device for serial femtosecond crystallography at atmospheric pressure J. Appl. Cryst., 52, 1280-1288 J. Appl. Cryst., 52, 1280-1288 J. Appl. Cryst., 52, 1280-1288 2019 有 英語 研究論文(学術雑誌) 公開
Asada H, Horita S, Hirata K, Shiroishi M, Shiimura Y, Iwanari H, Hamakubo T, Shimamura T, Nomura N, Kusano-Arai O, Uemura T, Suno C, Kobayashi T, Iwata S Asada H, Horita S, Hirata K, Shiroishi M, Shiimura Y, Iwanari H, Hamakubo T, Shimamura T, Nomura N, Kusano-Arai O, Uemura T, Suno C, Kobayashi T, Iwata S Asada H, Horita S, Hirata K, Shiroishi M, Shiimura Y, Iwanari H, Hamakubo T, Shimamura T, Nomura N, Kusano-Arai O, Uemura T, Suno C, Kobayashi T, Iwata S Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog. Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog. Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog. Nature structural & molecular biology, 25, 7, 570-576 Nature structural & molecular biology, 25, 7, 570-576 Nature structural & molecular biology, 25, 7, 570-576 2018/07 有 英語 研究論文(学術雑誌) 公開
Ryoji Suno, Kanako Terakado Kimura, Takanori Nakane, Keitaro Yamashita, Junmei Wang, Takaaki Fujiwara, Yasuaki Yamanaka, Dohyun Im, Shoichiro Horita, Hirokazu Tsujimoto, Maki S Tawaramoto, Takatsugu Hirokawa, Eriko Nango, Kensuke Tono, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Makina Yabashi, Keiko Shimamoto, Masaki Yamamoto, Daniel M Rosenbaum, So Iwata, Tatsuro Shimamura, Takuya Kobayashi Ryoji Suno, Kanako Terakado Kimura, Takanori Nakane, Keitaro Yamashita, Junmei Wang, Takaaki Fujiwara, Yasuaki Yamanaka, Dohyun Im, Shoichiro Horita, Hirokazu Tsujimoto, Maki S Tawaramoto, Takatsugu Hirokawa, Eriko Nango, Kensuke Tono, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Makina Yabashi, Keiko Shimamoto, Masaki Yamamoto, Daniel M Rosenbaum, So Iwata, Tatsuro Shimamura, Takuya Kobayashi Ryoji Suno, Kanako Terakado Kimura, Takanori Nakane, Keitaro Yamashita, Junmei Wang, Takaaki Fujiwara, Yasuaki Yamanaka, Dohyun Im, Shoichiro Horita, Hirokazu Tsujimoto, Maki S Tawaramoto, Takatsugu Hirokawa, Eriko Nango, Kensuke Tono, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Makina Yabashi, Keiko Shimamoto, Masaki Yamamoto, Daniel M Rosenbaum, So Iwata, Tatsuro Shimamura, Takuya Kobayashi Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA. Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA. Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA. Structure (London, England : 1993), 26, 1, 7-19 Structure (London, England : 1993), 26, 1, 7-19 Structure (London, England : 1993), 26, 1, 7-19 2018/01/02 有 英語 研究論文(学術雑誌) 公開
Eriko Nango, Antoine Royant, Minoru Kubo, Takanori Nakane, Cecilia Wickstrand, Tetsunari Kimura, Tomoyuki Tanaka, Kensuke Tono, Changyong Song, Rie Tanaka, Toshi Arima, Ayumi Yamashita, Jun Kobayashi, Toshiaki Hosaka, Eiichi Mizohata, Przemyslaw Nogly, Michihiro Sugahara, Daewoong Nam, Takashi Nomura, Tatsuro Shimamura, Dohyun Im, Takaaki Fujiwara, Yasuaki Yamanaka, Byeonghyun Jeon, Tomohiro Nishizawa, Kazumasa Oda, Masahiro Fukuda, Rebecka Andersson, Petra Bath, Robert Dods, Jan Davidsson, Shigeru Matsuoka, Satoshi Kawatake, Michio Murata, Osamu Nureki, Shigeki Owada, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Gebhard Schertler, Makina Yabashi, Ana-Nicoleta Bondar, Jorg Standfuss, Richard Neutze, So Iwata Eriko Nango, Antoine Royant, Minoru Kubo, Takanori Nakane, Cecilia Wickstrand, Tetsunari Kimura, Tomoyuki Tanaka, Kensuke Tono, Changyong Song, Rie Tanaka, Toshi Arima, Ayumi Yamashita, Jun Kobayashi, Toshiaki Hosaka, Eiichi Mizohata, Przemyslaw Nogly, Michihiro Sugahara, Daewoong Nam, Takashi Nomura, Tatsuro Shimamura, Dohyun Im, Takaaki Fujiwara, Yasuaki Yamanaka, Byeonghyun Jeon, Tomohiro Nishizawa, Kazumasa Oda, Masahiro Fukuda, Rebecka Andersson, Petra Bath, Robert Dods, Jan Davidsson, Shigeru Matsuoka, Satoshi Kawatake, Michio Murata, Osamu Nureki, Shigeki Owada, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Gebhard Schertler, Makina Yabashi, Ana-Nicoleta Bondar, Jorg Standfuss, Richard Neutze, So Iwata Eriko Nango, Antoine Royant, Minoru Kubo, Takanori Nakane, Cecilia Wickstrand, Tetsunari Kimura, Tomoyuki Tanaka, Kensuke Tono, Changyong Song, Rie Tanaka, Toshi Arima, Ayumi Yamashita, Jun Kobayashi, Toshiaki Hosaka, Eiichi Mizohata, Przemyslaw Nogly, Michihiro Sugahara, Daewoong Nam, Takashi Nomura, Tatsuro Shimamura, Dohyun Im, Takaaki Fujiwara, Yasuaki Yamanaka, Byeonghyun Jeon, Tomohiro Nishizawa, Kazumasa Oda, Masahiro Fukuda, Rebecka Andersson, Petra Bath, Robert Dods, Jan Davidsson, Shigeru Matsuoka, Satoshi Kawatake, Michio Murata, Osamu Nureki, Shigeki Owada, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Gebhard Schertler, Makina Yabashi, Ana-Nicoleta Bondar, Jorg Standfuss, Richard Neutze, So Iwata A three-dimensional movie of structural changes in bacteriorhodopsin A three-dimensional movie of structural changes in bacteriorhodopsin A three-dimensional movie of structural changes in bacteriorhodopsin SCIENCE, 354, 6319, 1552-1557 SCIENCE, 354, 6319, 1552-1557 SCIENCE, 354, 6319, 1552-1557 2016/12 有 英語 研究論文(学術雑誌) 公開
Takanori Nakane, Shinya Hanashima, Mamoru Suzuki, Haruka Saiki, Taichi Hayashi, Keisuke Kakinouchi, Shigeru Sugiyama, Satoshi Kawatake, Shigeru Matsuoka, Nobuaki Matsumori, Eriko Nango, Jun Kobayashi, Tatsuro Shimamura, Kanako Kimura, Chihiro Mori, Naoki Kunishima, Michihiro Sugahara, Yoko Takakyu, Shigeyuki Inoue, Tetsuya Masuda, Toshiaki Hosaka, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Tsuyoshi Inoue, Osamu Nureki, So Iwata, Michio Murata, Eiichi Mizohata Takanori Nakane, Shinya Hanashima, Mamoru Suzuki, Haruka Saiki, Taichi Hayashi, Keisuke Kakinouchi, Shigeru Sugiyama, Satoshi Kawatake, Shigeru Matsuoka, Nobuaki Matsumori, Eriko Nango, Jun Kobayashi, Tatsuro Shimamura, Kanako Kimura, Chihiro Mori, Naoki Kunishima, Michihiro Sugahara, Yoko Takakyu, Shigeyuki Inoue, Tetsuya Masuda, Toshiaki Hosaka, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Tsuyoshi Inoue, Osamu Nureki, So Iwata, Michio Murata, Eiichi Mizohata Takanori Nakane, Shinya Hanashima, Mamoru Suzuki, Haruka Saiki, Taichi Hayashi, Keisuke Kakinouchi, Shigeru Sugiyama, Satoshi Kawatake, Shigeru Matsuoka, Nobuaki Matsumori, Eriko Nango, Jun Kobayashi, Tatsuro Shimamura, Kanako Kimura, Chihiro Mori, Naoki Kunishima, Michihiro Sugahara, Yoko Takakyu, Shigeyuki Inoue, Tetsuya Masuda, Toshiaki Hosaka, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Tsuyoshi Inoue, Osamu Nureki, So Iwata, Michio Murata, Eiichi Mizohata Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113, 46, 13039-13044 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113, 46, 13039-13044 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113, 46, 13039-13044 2016/11 有 英語 研究論文(学術雑誌) 公開
Shoichiro Horita, Yayoi Nomura, Yumi Sato, Tatsuro Shimamura, So Iwata, Norimichi Nomura Shoichiro Horita, Yayoi Nomura, Yumi Sato, Tatsuro Shimamura, So Iwata, Norimichi Nomura Shoichiro Horita, Yayoi Nomura, Yumi Sato, Tatsuro Shimamura, So Iwata, Norimichi Nomura High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1 High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1 High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1 SCIENTIFIC REPORTS, 6, 35297 SCIENTIFIC REPORTS, 6, 35297 SCIENTIFIC REPORTS, 6, 35297 2016/10 有 英語 研究論文(学術雑誌) 公開
Yasuaki Kabe, Takanori Nakane, Ikko Koike, Tatsuya Yamamoto, Yuki Sugiura, Erisa Harada, Kenji Sugase, Tatsuro Shimamura, Mitsuyo Ohmura, Kazumi Muraoka, Ayumi Yamamoto, Takeshi Uchida, So Iwata, Yuki Yamaguchi, Elena Krayukhina, Masanori Noda, Hiroshi Handa, Koichiro Ishimori, Susumu Uchiyama, Takuya Kobayashi, Makoto Suematsu Yasuaki Kabe, Takanori Nakane, Ikko Koike, Tatsuya Yamamoto, Yuki Sugiura, Erisa Harada, Kenji Sugase, Tatsuro Shimamura, Mitsuyo Ohmura, Kazumi Muraoka, Ayumi Yamamoto, Takeshi Uchida, So Iwata, Yuki Yamaguchi, Elena Krayukhina, Masanori Noda, Hiroshi Handa, Koichiro Ishimori, Susumu Uchiyama, Takuya Kobayashi, Makoto Suematsu Yasuaki Kabe, Takanori Nakane, Ikko Koike, Tatsuya Yamamoto, Yuki Sugiura, Erisa Harada, Kenji Sugase, Tatsuro Shimamura, Mitsuyo Ohmura, Kazumi Muraoka, Ayumi Yamamoto, Takeshi Uchida, So Iwata, Yuki Yamaguchi, Elena Krayukhina, Masanori Noda, Hiroshi Handa, Koichiro Ishimori, Susumu Uchiyama, Takuya Kobayashi, Makoto Suematsu Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance NATURE COMMUNICATIONS, 7, 11030 NATURE COMMUNICATIONS, 7, 11030 NATURE COMMUNICATIONS, 7, 11030 2016/03 有 英語 研究論文(学術雑誌) 公開
Gregory Verdon, Norimichi Nomura, Hae Joo Kang, Tatsuro Shimamura, Yayoi Nomura, Saba Abdul Hussien, Aziz Abdul Qureshi, Mathieu Coincon, Yumi Sato, Yoshiko Nakada-Nakura, Takeshi Murata, Takuya Kobayashi, Michihiro Kasahara, So Iwata, David Drew Gregory Verdon, Norimichi Nomura, Hae Joo Kang, Tatsuro Shimamura, Yayoi Nomura, Saba Abdul Hussien, Aziz Abdul Qureshi, Mathieu Coincon, Yumi Sato, Yoshiko Nakada-Nakura, Takeshi Murata, Takuya Kobayashi, Michihiro Kasahara, So Iwata, David Drew Gregory Verdon, Norimichi Nomura, Hae Joo Kang, Tatsuro Shimamura, Yayoi Nomura, Saba Abdul Hussien, Aziz Abdul Qureshi, Mathieu Coincon, Yumi Sato, Yoshiko Nakada-Nakura, Takeshi Murata, Takuya Kobayashi, Michihiro Kasahara, So Iwata, David Drew Structure and Mechanism of the Mammalian Fructose Transporter GLUT5 Structure and Mechanism of the Mammalian Fructose Transporter GLUT5 Structure and Mechanism of the Mammalian Fructose Transporter GLUT5 BIOPHYSICAL JOURNAL, 110, 3, 137A-137A BIOPHYSICAL JOURNAL, 110, 3, 137A-137A BIOPHYSICAL JOURNAL, 110, 3, 137A-137A 2016/02 有 英語 公開
Nakane T, Hanashima S, Suzuki M, Saiki H, Hayashi T, Kakinouchi K, Sugiyama S, Kawatake S, Matsuoka S, Matsumori N, Nango E, Kobayashi J, Shimamura T, Kimura K, Mori C, Kunishima N, Sugahara M, Takakyu Y, Inoue S, Masuda T, Hosaka T, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Inoue T, Nureki O, Iwata S, Murata M, Mizohata E Nakane T, Hanashima S, Suzuki M, Saiki H, Hayashi T, Kakinouchi K, Sugiyama S, Kawatake S, Matsuoka S, Matsumori N, Nango E, Kobayashi J, Shimamura T, Kimura K, Mori C, Kunishima N, Sugahara M, Takakyu Y, Inoue S, Masuda T, Hosaka T, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Inoue T, Nureki O, Iwata S, Murata M, Mizohata E Nakane T, Hanashima S, Suzuki M, Saiki H, Hayashi T, Kakinouchi K, Sugiyama S, Kawatake S, Matsuoka S, Matsumori N, Nango E, Kobayashi J, Shimamura T, Kimura K, Mori C, Kunishima N, Sugahara M, Takakyu Y, Inoue S, Masuda T, Hosaka T, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Inoue T, Nureki O, Iwata S, Murata M, Mizohata E 5B35: Serial Femtosecond Crystallography (SFX) of Ground State Bacteriorhodopsin Crystallized from Bicelles Determined Using 7-keV X-ray Free Electron Laser (XFEL) at SACLA 5B35: Serial Femtosecond Crystallography (SFX) of Ground State Bacteriorhodopsin Crystallized from Bicelles Determined Using 7-keV X-ray Free Electron Laser (XFEL) at SACLA 5B35: Serial Femtosecond Crystallography (SFX) of Ground State Bacteriorhodopsin Crystallized from Bicelles Determined Using 7-keV X-ray Free Electron Laser (XFEL) at SACLA Worldwide Protein Data Bank Worldwide Protein Data Bank Worldwide Protein Data Bank 2016 有 公開
Takanori Nakane, Changyong Song, Mamoru Suzuki, Eriko Nango, Jun Kobayashi, Tetsuya Masuda, Shigeyuki Inoue, Eiichi Mizohata, Toru Nakatsu, Tomoyuki Tanaka, Rie Tanaka, Tatsuro Shimamura, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Osamu Nureki, So Iwata, Michihiro Sugahara Takanori Nakane, Changyong Song, Mamoru Suzuki, Eriko Nango, Jun Kobayashi, Tetsuya Masuda, Shigeyuki Inoue, Eiichi Mizohata, Toru Nakatsu, Tomoyuki Tanaka, Rie Tanaka, Tatsuro Shimamura, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Osamu Nureki, So Iwata, Michihiro Sugahara Takanori Nakane, Changyong Song, Mamoru Suzuki, Eriko Nango, Jun Kobayashi, Tetsuya Masuda, Shigeyuki Inoue, Eiichi Mizohata, Toru Nakatsu, Tomoyuki Tanaka, Rie Tanaka, Tatsuro Shimamura, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Osamu Nureki, So Iwata, Michihiro Sugahara Native sulfur/chlorine SAD phasing for serial femtosecond crystallography Native sulfur/chlorine SAD phasing for serial femtosecond crystallography Native sulfur/chlorine SAD phasing for serial femtosecond crystallography ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 71, 2519-2525 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 71, 2519-2525 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 71, 2519-2525 2015/12 有 英語 研究論文(学術雑誌) 公開
Norimichi Nomura, Gregory Verdon, Hae Joo Kang, Tatsuro Shimamura, Yayoi Nomura, Yo Sonoda, Saba Abdul Hussien, Aziz Abdul Qureshi, Mathieu Coincon, Yumi Sato, Hitomi Abe, Yoshiko Nakada-Nakura, Tomoya Hino, Takatoshi Arakawa, Osamu Kusano-Arai, Hiroko Iwanari, Takeshi Murata, Takuya Kobayashi, Takao Hamakubo, Michihiro Kasahara, So Iwata, David Drew Norimichi Nomura, Gregory Verdon, Hae Joo Kang, Tatsuro Shimamura, Yayoi Nomura, Yo Sonoda, Saba Abdul Hussien, Aziz Abdul Qureshi, Mathieu Coincon, Yumi Sato, Hitomi Abe, Yoshiko Nakada-Nakura, Tomoya Hino, Takatoshi Arakawa, Osamu Kusano-Arai, Hiroko Iwanari, Takeshi Murata, Takuya Kobayashi, Takao Hamakubo, Michihiro Kasahara, So Iwata, David Drew Norimichi Nomura, Gregory Verdon, Hae Joo Kang, Tatsuro Shimamura, Yayoi Nomura, Yo Sonoda, Saba Abdul Hussien, Aziz Abdul Qureshi, Mathieu Coincon, Yumi Sato, Hitomi Abe, Yoshiko Nakada-Nakura, Tomoya Hino, Takatoshi Arakawa, Osamu Kusano-Arai, Hiroko Iwanari, Takeshi Murata, Takuya Kobayashi, Takao Hamakubo, Michihiro Kasahara, So Iwata, David Drew Structure and mechanism of the mammalian fructose transporter GLUT5 Structure and mechanism of the mammalian fructose transporter GLUT5 Structure and mechanism of the mammalian fructose transporter GLUT5 NATURE, 526, 7573, 397-+ NATURE, 526, 7573, 397-+ NATURE, 526, 7573, 397-+ 2015/10 有 英語 研究論文(学術雑誌) 公開
Kensuke Tono, Eriko Nango, Michihiro Sugahara, Changyong Song, Jaehyun Park, Tomoyuki Tanaka, Rie Tanaka, Yasumasa Joti, Takashi Kameshima, Shun Ono, Takaki Hatsui, Eiichi Mizohata, Mamoru Suzuki, Tatsuro Shimamura, Yoshiki Tanaka, So Iwata, Makina Yabashi Kensuke Tono, Eriko Nango, Michihiro Sugahara, Changyong Song, Jaehyun Park, Tomoyuki Tanaka, Rie Tanaka, Yasumasa Joti, Takashi Kameshima, Shun Ono, Takaki Hatsui, Eiichi Mizohata, Mamoru Suzuki, Tatsuro Shimamura, Yoshiki Tanaka, So Iwata, Makina Yabashi Kensuke Tono, Eriko Nango, Michihiro Sugahara, Changyong Song, Jaehyun Park, Tomoyuki Tanaka, Rie Tanaka, Yasumasa Joti, Takashi Kameshima, Shun Ono, Takaki Hatsui, Eiichi Mizohata, Mamoru Suzuki, Tatsuro Shimamura, Yoshiki Tanaka, So Iwata, Makina Yabashi Diverse application platform for hard X-ray diffraction in SACLA (DAPHNIS): application to serial protein crystallography using an X-ray free-electron laser Diverse application platform for hard X-ray diffraction in SACLA (DAPHNIS): application to serial protein crystallography using an X-ray free-electron laser Diverse application platform for hard X-ray diffraction in SACLA (DAPHNIS): application to serial protein crystallography using an X-ray free-electron laser JOURNAL OF SYNCHROTRON RADIATION, 22, 532-537 JOURNAL OF SYNCHROTRON RADIATION, 22, 532-537 JOURNAL OF SYNCHROTRON RADIATION, 22, 532-537 2015/05 有 英語 研究論文(学術雑誌) 公開
Takanori Nakane, Changyong Song, Mamoru Suzuki, Eriko Nango, Jun Kobayashi, Tetsuya Masuda, Shigeyuki Inoue, Eiichi Mizohata, Toru Nakatsu, Tomoyuki Tanaka, Rie Tanaka, Tatsuro Shimamura, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Osamu Nureki, So Iwata, Michihiro Sugahara Takanori Nakane, Changyong Song, Mamoru Suzuki, Eriko Nango, Jun Kobayashi, Tetsuya Masuda, Shigeyuki Inoue, Eiichi Mizohata, Toru Nakatsu, Tomoyuki Tanaka, Rie Tanaka, Tatsuro Shimamura, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Osamu Nureki, So Iwata, Michihiro Sugahara Takanori Nakane, Changyong Song, Mamoru Suzuki, Eriko Nango, Jun Kobayashi, Tetsuya Masuda, Shigeyuki Inoue, Eiichi Mizohata, Toru Nakatsu, Tomoyuki Tanaka, Rie Tanaka, Tatsuro Shimamura, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Osamu Nureki, So Iwata, Michihiro Sugahara Native sulfur/chlorine SAD phasing for serial femtosecond crystallography Native sulfur/chlorine SAD phasing for serial femtosecond crystallography Native sulfur/chlorine SAD phasing for serial femtosecond crystallography Acta Crystallographica Section D: Biological Crystallography, 71, Pt 12, 2519-2525 Acta Crystallographica Section D: Biological Crystallography, 71, Pt 12, 2519-2525 Acta Crystallographica Section D: Biological Crystallography, 71, Pt 12, 2519-2525 2015 有 英語 研究論文(学術雑誌) 公開
Michihiro Sugahara, Eiichi Mizohata, Eriko Nango, Mamoru Suzuki, Tomoyuki Tanaka, Tetsuya Masudala, Rie Tanaka, Tatsuro Shimamura, Yoshiki Tanaka, Chiyo Suno, Kentaro Ihara, Dongqing Pan, Keisuke Kakinouchi, Shigeru Sugiyama, Michio Murata, Tsuyoshi Inoue, Kensuke Tono, Changyong Song, Jaehyun Park, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Makina Yabashi, So Iwata Michihiro Sugahara, Eiichi Mizohata, Eriko Nango, Mamoru Suzuki, Tomoyuki Tanaka, Tetsuya Masudala, Rie Tanaka, Tatsuro Shimamura, Yoshiki Tanaka, Chiyo Suno, Kentaro Ihara, Dongqing Pan, Keisuke Kakinouchi, Shigeru Sugiyama, Michio Murata, Tsuyoshi Inoue, Kensuke Tono, Changyong Song, Jaehyun Park, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Makina Yabashi, So Iwata Michihiro Sugahara, Eiichi Mizohata, Eriko Nango, Mamoru Suzuki, Tomoyuki Tanaka, Tetsuya Masudala, Rie Tanaka, Tatsuro Shimamura, Yoshiki Tanaka, Chiyo Suno, Kentaro Ihara, Dongqing Pan, Keisuke Kakinouchi, Shigeru Sugiyama, Michio Murata, Tsuyoshi Inoue, Kensuke Tono, Changyong Song, Jaehyun Park, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Makina Yabashi, So Iwata Grease matrix as a versatile carrier of proteins for serial crystallography Grease matrix as a versatile carrier of proteins for serial crystallography Grease matrix as a versatile carrier of proteins for serial crystallography NATURE METHODS, 12, 1, 61-63 NATURE METHODS, 12, 1, 61-63 NATURE METHODS, 12, 1, 61-63 2015/01 有 英語 研究論文(学術雑誌) 公開
Suharni, Yayoi Nomura, Takatoshi Arakawa, Tomoya Hino, Hitomi Abe, Yoshiko Nakada-Nakura, Yumi Sato, Hiroko Iwanari, Mitsunori Shiroishi, Hidetsugu Asada, Tatsuro Shimamura, Takeshi Murata, Takuya Kobayashi, Takao Hamakubo, So Iwata, Norimichi Nomura Suharni, Yayoi Nomura, Takatoshi Arakawa, Tomoya Hino, Hitomi Abe, Yoshiko Nakada-Nakura, Yumi Sato, Hiroko Iwanari, Mitsunori Shiroishi, Hidetsugu Asada, Tatsuro Shimamura, Takeshi Murata, Takuya Kobayashi, Takao Hamakubo, So Iwata, Norimichi Nomura Suharni, Yayoi Nomura, Takatoshi Arakawa, Tomoya Hino, Hitomi Abe, Yoshiko Nakada-Nakura, Yumi Sato, Hiroko Iwanari, Mitsunori Shiroishi, Hidetsugu Asada, Tatsuro Shimamura, Takeshi Murata, Takuya Kobayashi, Takao Hamakubo, So Iwata, Norimichi Nomura Proteoliposome-based Selection of a Recombinant Antibody Fragment Against the Human M2 Muscarinic Acetylcholine Receptor Proteoliposome-based Selection of a Recombinant Antibody Fragment Against the Human M2 Muscarinic Acetylcholine Receptor Proteoliposome-based Selection of a Recombinant Antibody Fragment Against the Human M2 Muscarinic Acetylcholine Receptor Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 33, 6, 378-385 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 33, 6, 378-385 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 33, 6, 378-385 2014/12 有 研究論文(学術雑誌) 公開
Koike-Takeshita A, Arakawa T, Taguchi H, Shimamura T Koike-Takeshita A, Arakawa T, Taguchi H, Shimamura T Ayumi Koike-Takeshita, Takatoshi Arakawa, Hideki Taguchi, Tatsuro Shimamura Crystal Structure of a Symmetric Football-Shaped GroEL:GroES2-ATP14 Complex Determined at 3.8Å Reveals Rearrangement between Two GroEL Rings. Crystal Structure of a Symmetric Football-Shaped GroEL:GroES2-ATP14 Complex Determined at 3.8Å Reveals Rearrangement between Two GroEL Rings. Crystal Structure of a Symmetric Football-Shaped GroEL:GroES(2)-ATP(14) Complex Determined at 3.8 angstrom Reveals Rearrangement between Two GroEL Rings Journal of molecular biology, 426, 21, 3634-3641 Journal of molecular biology, 426, 21, 3634-3641 JOURNAL OF MOLECULAR BIOLOGY, 426, 21, 3634-3641 2014/10 有 英語 研究論文(学術雑誌) 公開
Shimamura T Shimamura T Shimamura T [X-ray structure of histamine H1 receptor]. [X-ray structure of histamine H1 receptor]. [X-ray structure of histamine H1 receptor]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 144, 1, 43-44 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 144, 1, 43-44 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 144, 1, 43-44 2014/07 有 日本語 公開
Shimamura T, Iwata S Shimamura T, Iwata S Shimamura T, Iwata S [Structural biology and molecular targets]. [Structural biology and molecular targets]. [Structural biology and molecular targets]. Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 8, 316-320 Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 8, 316-320 Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 8, 316-320 2012/11 有 日本語 公開
Ryoji Suno, Masakazu Shimoyama, Akiko Abe, Tatsuro Shimamura, Natsuka Shimodate, Yo-hei Watanabe, Yoshinori Akiyama, Masasuke Yoshida Ryoji Suno, Masakazu Shimoyama, Akiko Abe, Tatsuro Shimamura, Natsuka Shimodate, Yo-hei Watanabe, Yoshinori Akiyama, Masasuke Yoshida Ryoji Suno, Masakazu Shimoyama, Akiko Abe, Tatsuro Shimamura, Natsuka Shimodate, Yo-hei Watanabe, Yoshinori Akiyama, Masasuke Yoshida Conformational transition of the lid helix covering the protease active site is essential for the ATP-dependent protease activity of FtsH Conformational transition of the lid helix covering the protease active site is essential for the ATP-dependent protease activity of FtsH Conformational transition of the lid helix covering the protease active site is essential for the ATP-dependent protease activity of FtsH FEBS LETTERS, 586, 19, 3117-3121 FEBS LETTERS, 586, 19, 3117-3121 FEBS LETTERS, 586, 19, 3117-3121 2012/09 有 英語 研究論文(学術雑誌) 公開
Mitsunori Shiroishi, Hirokazu Tsujimoto, Hisayoshi Makyio, Hidetsugu Asada, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Takeshi Murata, Norimichi Nomura, Tatsuya Haga, So Iwata, Takuya Kobayashi Mitsunori Shiroishi, Hirokazu Tsujimoto, Hisayoshi Makyio, Hidetsugu Asada, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Takeshi Murata, Norimichi Nomura, Tatsuya Haga, So Iwata, Takuya Kobayashi Mitsunori Shiroishi, Hirokazu Tsujimoto, Hisayoshi Makyio, Hidetsugu Asada, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Takeshi Murata, Norimichi Nomura, Tatsuya Haga, So Iwata, Takuya Kobayashi Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae MICROBIAL CELL FACTORIES, 11, 78 MICROBIAL CELL FACTORIES, 11, 78 MICROBIAL CELL FACTORIES, 11, 78 2012/06 有 英語 研究論文(学術雑誌) 公開
Tomoya Hino, Takatoshi Arakawa, Hiroko Iwanari, Takami Yurugi-Kobayashi, Chiyo Ikeda-Suno, Yoshiko Nakada-Nakura, Osamu Kusano-Arai, Simone Weyand, Tatsuro Shimamura, Norimichi Nomura, Alexander D. Cameron, Takuya Kobayashi, Takao Hamakubo, So Iwata, Takeshi Murata Tomoya Hino, Takatoshi Arakawa, Hiroko Iwanari, Takami Yurugi-Kobayashi, Chiyo Ikeda-Suno, Yoshiko Nakada-Nakura, Osamu Kusano-Arai, Simone Weyand, Tatsuro Shimamura, Norimichi Nomura, Alexander D. Cameron, Takuya Kobayashi, Takao Hamakubo, So Iwata, Takeshi Murata Tomoya Hino, Takatoshi Arakawa, Hiroko Iwanari, Takami Yurugi-Kobayashi, Chiyo Ikeda-Suno, Yoshiko Nakada-Nakura, Osamu Kusano-Arai, Simone Weyand, Tatsuro Shimamura, Norimichi Nomura, Alexander D. Cameron, Takuya Kobayashi, Takao Hamakubo, So Iwata, Takeshi Murata G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody NATURE, 482, 7384, 237-U130 NATURE, 482, 7384, 237-U130 NATURE, 482, 7384, 237-U130 2012/02 有 英語 研究論文(学術雑誌) 公開
Tatsuro Shimamura Tatsuro Shimamura Tatsuro Shimamura Structure of histamine H1 receptor Structure of histamine H1 receptor Structure of histamine H1 receptor Seikagaku, 84, 9, 772-776 Seikagaku, 84, 9, 772-776 Seikagaku, 84, 9, 772-776 2012 有 日本語 公開
Shiroishi M, Kobayashi T, Ogasawara S, Tsujimoto H, Ikeda-Suno C, Iwata S, Shimamura T Shiroishi M, Kobayashi T, Ogasawara S, Tsujimoto H, Ikeda-Suno C, Iwata S, Shimamura T Mitsunori Shiroishi, Takuya Kobayashi, Satoshi Ogasawara, Hirokazu Tsujimoto, Chiyo Ikeda-Suno, So Iwata, Tatsuro Shimamura Production of the stable human histamine H₁ receptor in Pichia pastoris for structural determination. Production of the stable human histamine H₁ receptor in Pichia pastoris for structural determination. Production of the stable human histamine H-1 receptor in Pichia pastoris for structural determination Methods (San Diego, Calif.), 55, 4, 281-286 Methods (San Diego, Calif.), 55, 4, 281-286 METHODS, 55, 4, 281-286 2011/12 有 英語 研究論文(学術雑誌) 公開
Chris de Graaf, Albert J. Kooistra, Henry F. Vischer, Vsevolod Katritch, Martien Kuijer, Mitsunori Shiroishi, So Iwata, Tatsuro Shimamura, Raymond C. Stevens, Iwan J. P. de Esch, Rob Leurs Chris de Graaf, Albert J. Kooistra, Henry F. Vischer, Vsevolod Katritch, Martien Kuijer, Mitsunori Shiroishi, So Iwata, Tatsuro Shimamura, Raymond C. Stevens, Iwan J. P. de Esch, Rob Leurs Chris de Graaf, Albert J. Kooistra, Henry F. Vischer, Vsevolod Katritch, Martien Kuijer, Mitsunori Shiroishi, So Iwata, Tatsuro Shimamura, Raymond C. Stevens, Iwan J. P. de Esch, Rob Leurs Crystal Structure-Based Virtual Screening for Fragment-like Ligands of the Human Histamine H-1 Receptor Crystal Structure-Based Virtual Screening for Fragment-like Ligands of the Human Histamine H-1 Receptor Crystal Structure-Based Virtual Screening for Fragment-like Ligands of the Human Histamine H-1 Receptor JOURNAL OF MEDICINAL CHEMISTRY, 54, 23, 8195-8206 JOURNAL OF MEDICINAL CHEMISTRY, 54, 23, 8195-8206 JOURNAL OF MEDICINAL CHEMISTRY, 54, 23, 8195-8206 2011/12 有 英語 研究論文(学術雑誌) 公開
Natsuko Tokuda, Kiyohiko Igarashi, Tatsuro Shimamura, Takami Yurugi-Kobayashi, Mitsunori Shiroishi, Keisuke Ito, Taishi Sugawara, Hidetsugu Asada, Takeshi Murata, Norimichi Nomura, So Iwata, Takuya Kobayashi Natsuko Tokuda, Kiyohiko Igarashi, Tatsuro Shimamura, Takami Yurugi-Kobayashi, Mitsunori Shiroishi, Keisuke Ito, Taishi Sugawara, Hidetsugu Asada, Takeshi Murata, Norimichi Nomura, So Iwata, Takuya Kobayashi Natsuko Tokuda, Kiyohiko Igarashi, Tatsuro Shimamura, Takami Yurugi-Kobayashi, Mitsunori Shiroishi, Keisuke Ito, Taishi Sugawara, Hidetsugu Asada, Takeshi Murata, Norimichi Nomura, So Iwata, Takuya Kobayashi Cloning, expression and purification of the anion exchanger 1 homologue from the basidiomycete Phanerochaete chrysosporium Cloning, expression and purification of the anion exchanger 1 homologue from the basidiomycete Phanerochaete chrysosporium Cloning, expression and purification of the anion exchanger 1 homologue from the basidiomycete Phanerochaete chrysosporium PROTEIN EXPRESSION AND PURIFICATION, 79, 1, 81-87 PROTEIN EXPRESSION AND PURIFICATION, 79, 1, 81-87 PROTEIN EXPRESSION AND PURIFICATION, 79, 1, 81-87 2011/09 有 英語 研究論文(学術雑誌) 公開
Tatsuro Shimamura, Mitsunori Shiroishi, Simone Weyand, Hirokazu Tsujimoto, Graeme Winter, Vsevolod Katritch, Ruben Abagyan, Vadim Cherezov, Wei Liu, Gye Won Han, Takuya Kobayashi, Raymond C. Stevens, So Iwata Tatsuro Shimamura, Mitsunori Shiroishi, Simone Weyand, Hirokazu Tsujimoto, Graeme Winter, Vsevolod Katritch, Ruben Abagyan, Vadim Cherezov, Wei Liu, Gye Won Han, Takuya Kobayashi, Raymond C. Stevens, So Iwata Tatsuro Shimamura, Mitsunori Shiroishi, Simone Weyand, Hirokazu Tsujimoto, Graeme Winter, Vsevolod Katritch, Ruben Abagyan, Vadim Cherezov, Wei Liu, Gye Won Han, Takuya Kobayashi, Raymond C. Stevens, So Iwata Structure of the human histamine H-1 receptor complex with doxepin Structure of the human histamine H-1 receptor complex with doxepin Structure of the human histamine H-1 receptor complex with doxepin NATURE, 475, 7354, 65-U82 NATURE, 475, 7354, 65-U82 NATURE, 475, 7354, 65-U82 2011/07 有 英語 研究論文(学術雑誌) 公開
Hidetsugu Asada, Tomoko Uemura, Takami Yurugi-Kobayashi, Mitsunori Shiroishi, Tatsuro Shimamura, Hirokazu Tsujimoto, Keisuke Ito, Taishi Sugawara, Takanori Nakane, Norimichi Nomura, Takeshi Murata, Tatsuya Haga, So Iwata, Takuya Kobayashi Hidetsugu Asada, Tomoko Uemura, Takami Yurugi-Kobayashi, Mitsunori Shiroishi, Tatsuro Shimamura, Hirokazu Tsujimoto, Keisuke Ito, Taishi Sugawara, Takanori Nakane, Norimichi Nomura, Takeshi Murata, Tatsuya Haga, So Iwata, Takuya Kobayashi Hidetsugu Asada, Tomoko Uemura, Takami Yurugi-Kobayashi, Mitsunori Shiroishi, Tatsuro Shimamura, Hirokazu Tsujimoto, Keisuke Ito, Taishi Sugawara, Takanori Nakane, Norimichi Nomura, Takeshi Murata, Tatsuya Haga, So Iwata, Takuya Kobayashi Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis MICROBIAL CELL FACTORIES, 10, 24 MICROBIAL CELL FACTORIES, 10, 24 MICROBIAL CELL FACTORIES, 10, 24 2011/04 有 英語 研究論文(学術雑誌) 公開
Keisuke Ito, Sohei Ito, Tatsuro Shimamura, Simone Weyand, Yasuaki Kawarasaki, Takumi Misaka, Keiko Abe, Takuya Kobayashi, Alexander D. Cameron, So Iwata Keisuke Ito, Sohei Ito, Tatsuro Shimamura, Simone Weyand, Yasuaki Kawarasaki, Takumi Misaka, Keiko Abe, Takuya Kobayashi, Alexander D. Cameron, So Iwata Keisuke Ito, Sohei Ito, Tatsuro Shimamura, Simone Weyand, Yasuaki Kawarasaki, Takumi Misaka, Keiko Abe, Takuya Kobayashi, Alexander D. Cameron, So Iwata Crystal Structure of Glucansucrase from the Dental Caries Pathogen Streptococcus mutans Crystal Structure of Glucansucrase from the Dental Caries Pathogen Streptococcus mutans Crystal Structure of Glucansucrase from the Dental Caries Pathogen Streptococcus mutans JOURNAL OF MOLECULAR BIOLOGY, 408, 2, 177-186 JOURNAL OF MOLECULAR BIOLOGY, 408, 2, 177-186 JOURNAL OF MOLECULAR BIOLOGY, 408, 2, 177-186 2011/04 有 英語 研究論文(学術雑誌) 公開
Simone Weyand, Tatsuro Shimamura, Oliver Beckstein, Mark S. P. Sansom, So Iwata, Peter J. F. Henderson, Alexander D. Cameron Simone Weyand, Tatsuro Shimamura, Oliver Beckstein, Mark S. P. Sansom, So Iwata, Peter J. F. Henderson, Alexander D. Cameron Simone Weyand, Tatsuro Shimamura, Oliver Beckstein, Mark S. P. Sansom, So Iwata, Peter J. F. Henderson, Alexander D. Cameron The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1 The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1 The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1 JOURNAL OF SYNCHROTRON RADIATION, 18, 20-23 JOURNAL OF SYNCHROTRON RADIATION, 18, 20-23 JOURNAL OF SYNCHROTRON RADIATION, 18, 20-23 2011/01 有 英語 研究論文(学術雑誌) 公開
Takuya Kobayashi, Mitsunori Shiroishi, Tatsuro Shimamura, Takami Yurugi, Hidetsugu Asada, Tomoya Hino, Takatoshi Arakawa, Takeshi Murata, Norimichi Nomura, So Iwata Takuya Kobayashi, Mitsunori Shiroishi, Tatsuro Shimamura, Takami Yurugi, Hidetsugu Asada, Tomoya Hino, Takatoshi Arakawa, Takeshi Murata, Norimichi Nomura, So Iwata Takuya Kobayashi, Mitsunori Shiroishi, Tatsuro Shimamura, Takami Yurugi, Hidetsugu Asada, Tomoya Hino, Takatoshi Arakawa, Takeshi Murata, Norimichi Nomura, So Iwata Towards structure determination for G protein-coupled receptor Towards structure determination for G protein-coupled receptor Towards structure determination for G protein-coupled receptor JOURNAL OF PHARMACOLOGICAL SCIENCES, 115, 59P-59P JOURNAL OF PHARMACOLOGICAL SCIENCES, 115, 59P-59P JOURNAL OF PHARMACOLOGICAL SCIENCES, 115, 59P-59P 2011 有 英語 公開
Keisuke Ito, Taishi Sugawara, Ayako Koizumi, Ken-ichiro Nakajima, Akiko Shimizu-Ibuka, Mitsunori Shiroishi, Hidetsugu Asada, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Tomiko Asakura, Takumi Misaka, So Iwata, Takuya Kobayashi, Keiko Abe Keisuke Ito, Taishi Sugawara, Ayako Koizumi, Ken-ichiro Nakajima, Akiko Shimizu-Ibuka, Mitsunori Shiroishi, Hidetsugu Asada, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Tomiko Asakura, Takumi Misaka, So Iwata, Takuya Kobayashi, Keiko Abe Keisuke Ito, Taishi Sugawara, Ayako Koizumi, Ken-ichiro Nakajima, Akiko Shimizu-Ibuka, Mitsunori Shiroishi, Hidetsugu Asada, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Tomiko Asakura, Takumi Misaka, So Iwata, Takuya Kobayashi, Keiko Abe Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion: case of a nonglycosylated mutant of miraculin, a taste-modifying protein Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion: case of a nonglycosylated mutant of miraculin, a taste-modifying protein Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion: case of a nonglycosylated mutant of miraculin, a taste-modifying protein BIOTECHNOLOGY LETTERS, 33, 1, 103-107 BIOTECHNOLOGY LETTERS, 33, 1, 103-107 BIOTECHNOLOGY LETTERS, 33, 1, 103-107 2011/01 有 英語 研究論文(学術雑誌) 公開
Keisuke Ito, Sohei Ito, Tatsuro Shimamura, Yasuaki Kawarasaki, Keiko Abe, Takumi Misaka, Takuya Kobayashi, So Iwata Keisuke Ito, Sohei Ito, Tatsuro Shimamura, Yasuaki Kawarasaki, Keiko Abe, Takumi Misaka, Takuya Kobayashi, So Iwata Keisuke Ito, Sohei Ito, Tatsuro Shimamura, Yasuaki Kawarasaki, Keiko Abe, Takumi Misaka, Takuya Kobayashi, So Iwata Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 66, Pt 9, 1086-1088 ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 66, Pt 9, 1086-1088 ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 66, Pt 9, 1086-1088 2010/09 有 英語 研究論文(学術雑誌) 公開
Keisuke Ito, Taishi Sugawara, Ayako Koizumi, Ken-ichiro Nakajima, Akiko Shimizu-Ibuka, Mitsunori Shiroishi, Hidetsugu Asada, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Tomiko Asakura, Katsuyoshi Masuda, Masaji Ishiguro, Takumi Misaka, So Iwata, Takuya Kobayashi, Keiko Abe Keisuke Ito, Taishi Sugawara, Ayako Koizumi, Ken-ichiro Nakajima, Akiko Shimizu-Ibuka, Mitsunori Shiroishi, Hidetsugu Asada, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Tomiko Asakura, Katsuyoshi Masuda, Masaji Ishiguro, Takumi Misaka, So Iwata, Takuya Kobayashi, Keiko Abe Keisuke Ito, Taishi Sugawara, Ayako Koizumi, Ken-ichiro Nakajima, Akiko Shimizu-Ibuka, Mitsunori Shiroishi, Hidetsugu Asada, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Tomiko Asakura, Katsuyoshi Masuda, Masaji Ishiguro, Takumi Misaka, So Iwata, Takuya Kobayashi, Keiko Abe Bulky high-mannose-type N-glycan blocks the taste-modifying activity of miraculin Bulky high-mannose-type N-glycan blocks the taste-modifying activity of miraculin Bulky high-mannose-type N-glycan blocks the taste-modifying activity of miraculin BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1800, 9, 986-992 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1800, 9, 986-992 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1800, 9, 986-992 2010/09 有 英語 研究論文(学術雑誌) 公開
Tatsuro Shimamura, Simone Weyand, Oliver Beckstein, Nicholas G. Rutherford, Jonathan M. Hadden, David Sharples, Mark S. P. Sansom, So Iwata, Peter J. F. Henderson, Alexander D. Cameron Tatsuro Shimamura, Simone Weyand, Oliver Beckstein, Nicholas G. Rutherford, Jonathan M. Hadden, David Sharples, Mark S. P. Sansom, So Iwata, Peter J. F. Henderson, Alexander D. Cameron Tatsuro Shimamura, Simone Weyand, Oliver Beckstein, Nicholas G. Rutherford, Jonathan M. Hadden, David Sharples, Mark S. P. Sansom, So Iwata, Peter J. F. Henderson, Alexander D. Cameron Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1 Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1 Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1 SCIENCE, 328, 5977, 470-473 SCIENCE, 328, 5977, 470-473 SCIENCE, 328, 5977, 470-473 2010/04 有 英語 研究論文(学術雑誌) 公開
Yasushi Nitanai, Tatsuro Shimamura, Takuro Uchiyama, Yoshikazu Ishii, Michiyo Takehira, Katsuhide Yutani, Hiroshi Matsuzawa, Masashi Miyano Yasushi Nitanai, Tatsuro Shimamura, Takuro Uchiyama, Yoshikazu Ishii, Michiyo Takehira, Katsuhide Yutani, Hiroshi Matsuzawa, Masashi Miyano Yasushi Nitanai, Tatsuro Shimamura, Takuro Uchiyama, Yoshikazu Ishii, Michiyo Takehira, Katsuhide Yutani, Hiroshi Matsuzawa, Masashi Miyano The catalytic efficiency (k(cat)/K-m) of the class A beta-lactamase Toho-1 correlates with the thermal stability of its catalytic intermediate analog The catalytic efficiency (k(cat)/K-m) of the class A beta-lactamase Toho-1 correlates with the thermal stability of its catalytic intermediate analog The catalytic efficiency (k(cat)/K-m) of the class A beta-lactamase Toho-1 correlates with the thermal stability of its catalytic intermediate analog BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1804, 4, 684-691 BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1804, 4, 684-691 BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1804, 4, 684-691 2010/04 有 英語 研究論文(学術雑誌) 公開
Taishi Sugawara, Keisuke Ito, Mitsunori Shiroishi, Natsuko Tokuda, Hidetsugu Asada, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Takumi Misaka, Norimichi Nomura, Takeshi Murata, Keiko Abe, So Iwata, Takuya Kobayashi Taishi Sugawara, Keisuke Ito, Mitsunori Shiroishi, Natsuko Tokuda, Hidetsugu Asada, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Takumi Misaka, Norimichi Nomura, Takeshi Murata, Keiko Abe, So Iwata, Takuya Kobayashi Taishi Sugawara, Keisuke Ito, Mitsunori Shiroishi, Natsuko Tokuda, Hidetsugu Asada, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Takumi Misaka, Norimichi Nomura, Takeshi Murata, Keiko Abe, So Iwata, Takuya Kobayashi Fluorescence-based optimization of human bitter taste receptor expression in Saccharomyces cerevisiae Fluorescence-based optimization of human bitter taste receptor expression in Saccharomyces cerevisiae Fluorescence-based optimization of human bitter taste receptor expression in Saccharomyces cerevisiae BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 382, 4, 704-710 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 382, 4, 704-710 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 382, 4, 704-710 2009/05 有 英語 研究論文(学術雑誌) 公開
Tatsuro Shimamura, Yasushi Nitanai, Takuro Uchiyama, Hiroshi Matsuzawa Tatsuro Shimamura, Yasushi Nitanai, Takuro Uchiyama, Hiroshi Matsuzawa Tatsuro Shimamura, Yasushi Nitanai, Takuro Uchiyama, Hiroshi Matsuzawa Improvement of crystal quality by surface mutations of beta-lactamase Toho-1 Improvement of crystal quality by surface mutations of beta-lactamase Toho-1 Improvement of crystal quality by surface mutations of beta-lactamase Toho-1 ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 65, Pt 4, 379-382 ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 65, Pt 4, 379-382 ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 65, Pt 4, 379-382 2009/04 有 英語 研究論文(学術雑誌) 公開
Takami Yurugi-Kobayashi, Hidetsugu Asada, Mitsunori Shiroishi, Tatsuro Shimamura, Saeko Funamoto, Naoko Katsuta, Keisuke Ito, Taishi Sugawara, Natsuko Tokuda, Hirokazu Tsujimoto, Takeshi Murata, Norimichi Nomura, Kazuko Haga, Tatsuya Haga, So Iwata, Takuya Kobayashi Takami Yurugi-Kobayashi, Hidetsugu Asada, Mitsunori Shiroishi, Tatsuro Shimamura, Saeko Funamoto, Naoko Katsuta, Keisuke Ito, Taishi Sugawara, Natsuko Tokuda, Hirokazu Tsujimoto, Takeshi Murata, Norimichi Nomura, Kazuko Haga, Tatsuya Haga, So Iwata, Takuya Kobayashi Takami Yurugi-Kobayashi, Hidetsugu Asada, Mitsunori Shiroishi, Tatsuro Shimamura, Saeko Funamoto, Naoko Katsuta, Keisuke Ito, Taishi Sugawara, Natsuko Tokuda, Hirokazu Tsujimoto, Takeshi Murata, Norimichi Nomura, Kazuko Haga, Tatsuya Haga, So Iwata, Takuya Kobayashi Comparison of functional non-glycosylated GPCRs expression in Pichia pastoris Comparison of functional non-glycosylated GPCRs expression in Pichia pastoris Comparison of functional non-glycosylated GPCRs expression in Pichia pastoris BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 380, 2, 271-276 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 380, 2, 271-276 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 380, 2, 271-276 2009/03 有 英語 研究論文(学術雑誌) 公開
Tatsuro Shimamura, Shunsuke Yajima, Shun'ichi Suzuki, Nicholas G. Rutherford, John O'Reilly, Peter J. F. Henderson, So Iwata Tatsuro Shimamura, Shunsuke Yajima, Shun'ichi Suzuki, Nicholas G. Rutherford, John O'Reilly, Peter J. F. Henderson, So Iwata Tatsuro Shimamura, Shunsuke Yajima, Shun'ichi Suzuki, Nicholas G. Rutherford, John O'Reilly, Peter J. F. Henderson, So Iwata Crystallization of the hydantoin transporter Mhp1 from Microbacterium liquefaciens Crystallization of the hydantoin transporter Mhp1 from Microbacterium liquefaciens Crystallization of the hydantoin transporter Mhp1 from Microbacterium liquefaciens ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 64, Pt 12, 1172-1174 ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 64, Pt 12, 1172-1174 ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 64, Pt 12, 1172-1174 2008/12 有 英語 研究論文(学術雑誌) 公開
Simone Weyand, Tatsuro Shimamura, Shunsuke Yajima, Shun&apos, ichi Suzuki, Osman Mirza, Kuakarun Krusong, Elisabeth P. Carpenter, Nicholas G. Rutherford, Jonathan M. Hadden, John O&apos, Reilly, Pikyee Ma, Massoud Saidijam, Simon G. Patching, Ryan J. Hope, Halina T. Norbertczak, Peter C. J. Roach, So Iwata, Peter J. F. Henderson, Alexander D. Cameron Simone Weyand, Tatsuro Shimamura, Shunsuke Yajima, Shun&apos, ichi Suzuki, Osman Mirza, Kuakarun Krusong, Elisabeth P. Carpenter, Nicholas G. Rutherford, Jonathan M. Hadden, John O&apos, Reilly, Pikyee Ma, Massoud Saidijam, Simon G. Patching, Ryan J. Hope, Halina T. Norbertczak, Peter C. J. Roach, So Iwata, Peter J. F. Henderson, Alexander D. Cameron Simone Weyand, Tatsuro Shimamura, Shunsuke Yajima, Shun&apos, ichi Suzuki, Osman Mirza, Kuakarun Krusong, Elisabeth P. Carpenter, Nicholas G. Rutherford, Jonathan M. Hadden, John O&apos, Reilly, Pikyee Ma, Massoud Saidijam, Simon G. Patching, Ryan J. Hope, Halina T. Norbertczak, Peter C. J. Roach, So Iwata, Peter J. F. Henderson, Alexander D. Cameron Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter SCIENCE, 322, 5902, 709-713 SCIENCE, 322, 5902, 709-713 SCIENCE, 322, 5902, 709-713 2008/10 有 英語 研究論文(学術雑誌) 公開
Keisuke Ito, Taishi Sugawara, Mitsunori Shiroishi, Natsuko Tokuda, Azusa Kurokawa, Takumi Misaka, Hisayoshi Makyio, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Norimichi Nomura, Takeshi Murata, Keiko Abe, So Iwata, Takuya Kobayashi Keisuke Ito, Taishi Sugawara, Mitsunori Shiroishi, Natsuko Tokuda, Azusa Kurokawa, Takumi Misaka, Hisayoshi Makyio, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Norimichi Nomura, Takeshi Murata, Keiko Abe, So Iwata, Takuya Kobayashi Keisuke Ito, Taishi Sugawara, Mitsunori Shiroishi, Natsuko Tokuda, Azusa Kurokawa, Takumi Misaka, Hisayoshi Makyio, Takami Yurugi-Kobayashi, Tatsuro Shimamura, Norimichi Nomura, Takeshi Murata, Keiko Abe, So Iwata, Takuya Kobayashi Advanced method for high-throughput expression of mutated eukaryotic membrane proteins in Saccharomyces cerevisiae Advanced method for high-throughput expression of mutated eukaryotic membrane proteins in Saccharomyces cerevisiae Advanced method for high-throughput expression of mutated eukaryotic membrane proteins in Saccharomyces cerevisiae BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 371, 4, 841-845 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 371, 4, 841-845 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 371, 4, 841-845 2008/07 有 英語 研究論文(学術雑誌) 公開
Mika Jormakka, Ken Yokoyama, Takahiro Yano, Masatada Tamakoshi, Satoru Akimoto, Tatsuro Shimamura, Paul Curmi, So Iwata Mika Jormakka, Ken Yokoyama, Takahiro Yano, Masatada Tamakoshi, Satoru Akimoto, Tatsuro Shimamura, Paul Curmi, So Iwata Mika Jormakka, Ken Yokoyama, Takahiro Yano, Masatada Tamakoshi, Satoru Akimoto, Tatsuro Shimamura, Paul Curmi, So Iwata Molecular mechanism of energy conservation in polysulfide respiration Molecular mechanism of energy conservation in polysulfide respiration Molecular mechanism of energy conservation in polysulfide respiration NATURE STRUCTURAL & MOLECULAR BIOLOGY, 15, 7, 730-737 NATURE STRUCTURAL & MOLECULAR BIOLOGY, 15, 7, 730-737 NATURE STRUCTURAL & MOLECULAR BIOLOGY, 15, 7, 730-737 2008/07 有 英語 研究論文(学術雑誌) 公開
Tatsuro Shimamura, Kenji Hiraki, Naoko Takahashi, Tetsuya Hori, Hideo Ago, Katsuyoshi Masuda, Koji Takio, Masaji Ishiguro, Masashi Miyano Tatsuro Shimamura, Kenji Hiraki, Naoko Takahashi, Tetsuya Hori, Hideo Ago, Katsuyoshi Masuda, Koji Takio, Masaji Ishiguro, Masashi Miyano Tatsuro Shimamura, Kenji Hiraki, Naoko Takahashi, Tetsuya Hori, Hideo Ago, Katsuyoshi Masuda, Koji Takio, Masaji Ishiguro, Masashi Miyano Crystal structure of squid rhodopsin with intracellularly extended cytoplasmic region Crystal structure of squid rhodopsin with intracellularly extended cytoplasmic region Crystal structure of squid rhodopsin with intracellularly extended cytoplasmic region JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 26, 17753-17756 JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 26, 17753-17756 JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 26, 17753-17756 2008/06 有 英語 研究論文(学術雑誌) 公開
Hideo Ago, Yoshihide Kanaoka, Daisuke Irikura, Bing K. Lam, Tatsuro Shimamura, K. Frank Austen, Masashi Miyano Hideo Ago, Yoshihide Kanaoka, Daisuke Irikura, Bing K. Lam, Tatsuro Shimamura, K. Frank Austen, Masashi Miyano Hideo Ago, Yoshihide Kanaoka, Daisuke Irikura, Bing K. Lam, Tatsuro Shimamura, K. Frank Austen, Masashi Miyano Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis NATURE, 448, 7153, 609-U12 NATURE, 448, 7153, 609-U12 NATURE, 448, 7153, 609-U12 2007/08 有 英語 研究論文(学術雑誌) 公開
Hitoshi Nakayama, Tatsuro Shimamura, Takahito Imagawa, Nobuaki Shirai, Takashi Itoh, Yoshihiko Sako, Masashi Miyano, Haruhiko Sakuraba, Toshihisa Ohshima, Norimichi Nomura, Hideaki Tsuge Hitoshi Nakayama, Tatsuro Shimamura, Takahito Imagawa, Nobuaki Shirai, Takashi Itoh, Yoshihiko Sako, Masashi Miyano, Haruhiko Sakuraba, Toshihisa Ohshima, Norimichi Nomura, Hideaki Tsuge Hitoshi Nakayama, Tatsuro Shimamura, Takahito Imagawa, Nobuaki Shirai, Takashi Itoh, Yoshihiko Sako, Masashi Miyano, Haruhiko Sakuraba, Toshihisa Ohshima, Norimichi Nomura, Hideaki Tsuge Structure of a hyperthermophilic archaeal homing endonuclease, I-Tsp061I: Contribution of cross-domain polar networks to thermostability Structure of a hyperthermophilic archaeal homing endonuclease, I-Tsp061I: Contribution of cross-domain polar networks to thermostability Structure of a hyperthermophilic archaeal homing endonuclease, I-Tsp061I: Contribution of cross-domain polar networks to thermostability JOURNAL OF MOLECULAR BIOLOGY, 365, 2, 362-378 JOURNAL OF MOLECULAR BIOLOGY, 365, 2, 362-378 JOURNAL OF MOLECULAR BIOLOGY, 365, 2, 362-378 2007/01 有 英語 研究論文(学術雑誌) 公開
A Koike-Takeshita, T Shimamura, K Yokoyama, M Yoshida, H Taguchi A Koike-Takeshita, T Shimamura, K Yokoyama, M Yoshida, H Taguchi A Koike-Takeshita, T Shimamura, K Yokoyama, M Yoshida, H Taguchi Leu(309) plays a critical role in the encapsulation of substrate protein into the internal cavity of GroEL Leu(309) plays a critical role in the encapsulation of substrate protein into the internal cavity of GroEL Leu(309) plays a critical role in the encapsulation of substrate protein into the internal cavity of GroEL JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 2, 962-967 JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 2, 962-967 JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 2, 962-967 2006/01 有 英語 研究論文(学術雑誌) 公開
T Shimamura, A Koike-Takeshita, K Yokoyama, R Masui, N Murai, M Yoshida, H Taguchi, S Iwata T Shimamura, A Koike-Takeshita, K Yokoyama, R Masui, N Murai, M Yoshida, H Taguchi, S Iwata T Shimamura, A Koike-Takeshita, K Yokoyama, R Masui, N Murai, M Yoshida, H Taguchi, S Iwata Crystal structure of the native chaperonin complex from Thermus thermophilus revealed unexpected asymmetry at the cis-cavity Crystal structure of the native chaperonin complex from Thermus thermophilus revealed unexpected asymmetry at the cis-cavity Crystal structure of the native chaperonin complex from Thermus thermophilus revealed unexpected asymmetry at the cis-cavity STRUCTURE, 12, 8, 1471-1480 STRUCTURE, 12, 8, 1471-1480 STRUCTURE, 12, 8, 1471-1480 2004/08 有 英語 研究論文(学術雑誌) 公開
T Shimamura, O Shamotienko, S Akhtar, JO Dolly, S Iwata T Shimamura, O Shamotienko, S Akhtar, JO Dolly, S Iwata T Shimamura, O Shamotienko, S Akhtar, JO Dolly, S Iwata Crystallization and preliminary X-ray analysis of pseudo-merohedrally twinned crystals of the full-length beta(2) subunit of the Kv1 K+ channel from Rattus norvegicus Crystallization and preliminary X-ray analysis of pseudo-merohedrally twinned crystals of the full-length beta(2) subunit of the Kv1 K+ channel from Rattus norvegicus Crystallization and preliminary X-ray analysis of pseudo-merohedrally twinned crystals of the full-length beta(2) subunit of the Kv1 K+ channel from Rattus norvegicus ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 60, Pt 5, 912-914 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 60, Pt 5, 912-914 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 60, Pt 5, 912-914 2004/05 有 英語 研究論文(学術雑誌) 公開
T Shimamura, A Koike-Takeshita, K Yokoyama, M Yoshida, H Taguchi, S Iwata T Shimamura, A Koike-Takeshita, K Yokoyama, M Yoshida, H Taguchi, S Iwata T Shimamura, A Koike-Takeshita, K Yokoyama, M Yoshida, H Taguchi, S Iwata Crystallization of the chaperonin GroEL-GroES complex from Thermus thermophilus HB8 Crystallization of the chaperonin GroEL-GroES complex from Thermus thermophilus HB8 Crystallization of the chaperonin GroEL-GroES complex from Thermus thermophilus HB8 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 59, Pt 9, 1632-1634 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 59, Pt 9, 1632-1634 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 59, Pt 9, 1632-1634 2003/09 有 英語 研究論文(学術雑誌) 公開
T Shimamura, A Ibuka, S Fushinobu, T Wakagi, M Ishiguro, Y Ishii, H Matsuzawa T Shimamura, A Ibuka, S Fushinobu, T Wakagi, M Ishiguro, Y Ishii, H Matsuzawa T Shimamura, A Ibuka, S Fushinobu, T Wakagi, M Ishiguro, Y Ishii, H Matsuzawa Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 48, 46601-46608 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 48, 46601-46608 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 48, 46601-46608 2002/11 有 英語 研究論文(学術雑誌) 公開

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中根崇智, 花島慎弥, 鈴木守, 鈴木守, 斎木悠, 林太一, 垣之内啓介, 垣之内啓介, 杉山成, 杉山成, 川竹悟史, 川竹悟史, 松岡茂, 松岡茂, 松森信明, 南後恵理子, 小林淳, 島村達郎, 木村香菜子, 森千寿, 国島直樹, 菅原道泰, 高久陽子, 井上茂之, 井上茂之, 桝田哲哉, 桝田哲哉, 保坂俊彰, 登野健介, 城地保昌, 亀島敬, 初井宇記, 矢橋牧名, 井上豪, 濡木理, 岩田想, 岩田想, 村田道雄, 村田道雄, 溝端栄一 中根崇智, 花島慎弥, 鈴木守, 鈴木守, 斎木悠, 林太一, 垣之内啓介, 垣之内啓介, 杉山成, 杉山成, 川竹悟史, 川竹悟史, 松岡茂, 松岡茂, 松森信明, 南後恵理子, 小林淳, 島村達郎, 木村香菜子, 森千寿, 国島直樹, 菅原道泰, 高久陽子, 井上茂之, 井上茂之, 桝田哲哉, 桝田哲哉, 保坂俊彰, 登野健介, 城地保昌, 亀島敬, 初井宇記, 矢橋牧名, 井上豪, 濡木理, 岩田想, 岩田想, 村田道雄, 村田道雄, 溝端栄一 中根崇智, 花島慎弥, 鈴木守, 鈴木守, 斎木悠, 林太一, 垣之内啓介, 垣之内啓介, 杉山成, 杉山成, 川竹悟史, 川竹悟史, 松岡茂, 松岡茂, 松森信明, 南後恵理子, 小林淳, 島村達郎, 木村香菜子, 森千寿, 国島直樹, 菅原道泰, 高久陽子, 井上茂之, 井上茂之, 桝田哲哉, 桝田哲哉, 保坂俊彰, 登野健介, 城地保昌, 亀島敬, 初井宇記, 矢橋牧名, 井上豪, 濡木理, 岩田想, 岩田想, 村田道雄, 村田道雄, 溝端栄一 膜蛋白質のSFXによる迅速位相決定を志向したヨウ素含有界面活性剤の開発 膜蛋白質のSFXによる迅速位相決定を志向したヨウ素含有界面活性剤の開発 膜蛋白質のSFXによる迅速位相決定を志向したヨウ素含有界面活性剤の開発 日本結晶学会年会講演要旨集, 2016, 112 日本結晶学会年会講演要旨集, 2016, 112 日本結晶学会年会講演要旨集, 2016, 112 2016/11/17 日本語 公開
田中智之, 菅原道泰, 山下鮎美, 小林淳, 田中里枝, 登野健介, 城地保昌, 亀島敬, PARK Jaehyun, SONG Changyong, 初井宇記, 矢橋牧名, 潘東青, 島村達郎, 溝端栄一, 岩田想, 南後恵理子 田中智之, 菅原道泰, 山下鮎美, 小林淳, 田中里枝, 登野健介, 城地保昌, 亀島敬, PARK Jaehyun, SONG Changyong, 初井宇記, 矢橋牧名, 潘東青, 島村達郎, 溝端栄一, 岩田想, 南後恵理子 田中智之, 菅原道泰, 山下鮎美, 小林淳, 田中里枝, 登野健介, 城地保昌, 亀島敬, PARK Jaehyun, SONG Changyong, 初井宇記, 矢橋牧名, 潘東青, 島村達郎, 溝端栄一, 岩田想, 南後恵理子 シリアルフェムト秒X線結晶構造解析のための試料調製方法 シリアルフェムト秒X線結晶構造解析のための試料調製方法 シリアルフェムト秒X線結晶構造解析のための試料調製方法 日本蛋白質科学会年会プログラム・要旨集, 15th, 95 日本蛋白質科学会年会プログラム・要旨集, 15th, 95 日本蛋白質科学会年会プログラム・要旨集, 15th, 95 2015/05/26 日本語 公開
寿野良二, 島村達郎, 阿部明子, 日野智也, 渡辺洋平, 下立夏香, 秋山芳展, 岩田想, 吉田賢右 寿野良二, 島村達郎, 阿部明子, 日野智也, 渡辺洋平, 下立夏香, 秋山芳展, 岩田想, 吉田賢右 SUNO RYOJI, SHIMAMURA TATSURO, ABE AKIKO, HINO TOMOYA, WATANABE YOHEI, SHIMODATE NATSUKA, AKIYAMA YOSHINORI, IWATA SO, YOSHIDA MASASUKE AAA+プロテアーゼFtsHのATP依存的な構造変化にともなう基質ポリペプチド鎖分解メカニズム AAA+プロテアーゼFtsHのATP依存的な構造変化にともなう基質ポリペプチド鎖分解メカニズム AAA+プロテアーゼFtsHのATP依存的な構造変化にともなう基質ポリペプチド鎖分解メカニズム 日本蛋白質科学会年会プログラム・要旨集, 13th, 53 日本蛋白質科学会年会プログラム・要旨集, 13th, 53 日本蛋白質科学会年会プログラム・要旨集, 13th, 53 2013/05/31 日本語 公開
Takuya Kobayashi, Mitsunori Shiroishi, Hidetsugu Asada, Takami Yurugi, Tatsuro Shimamura, So Iwate Takuya Kobayashi, Mitsunori Shiroishi, Hidetsugu Asada, Takami Yurugi, Tatsuro Shimamura, So Iwate Takuya Kobayashi, Mitsunori Shiroishi, Hidetsugu Asada, Takami Yurugi, Tatsuro Shimamura, So Iwate Strategy for the structure determination of G protein-coupled receptor Strategy for the structure determination of G protein-coupled receptor Strategy for the structure determination of G protein-coupled receptor JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 37P-37P JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 37P-37P JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 37P-37P 2012 英語 研究発表ペーパー要旨(国際会議) 公開
寿野良二, 島村達郎, 阿部明子, 日野智也, 下立夏香, 渡辺洋平, 秋山芳展, 岩田想, 吉田賢右 寿野良二, 島村達郎, 阿部明子, 日野智也, 下立夏香, 渡辺洋平, 秋山芳展, 岩田想, 吉田賢右 SUNO RYOJI, SHIMAMURA TATSURO, ABE AKIKO, HINO TOMOYA, SHIMODATE NATSUKA, WATANABE YOHEI, AKIYAMA YOSHINORI, IWATA SO, YOSHIDA MASASUKE 膜結合型AAA+プロテアーゼFtsHのATP結合による基質ポリペプチド分解メカニズム 膜結合型AAA+プロテアーゼFtsHのATP結合による基質ポリペプチド分解メカニズム 膜結合型AAA+プロテアーゼFtsHのATP結合による基質ポリペプチド分解メカニズム 日本生化学会大会(Web), 85th, 2T08-09 (WEB ONLY) 日本生化学会大会(Web), 85th, 2T08-09 (WEB ONLY) 日本生化学会大会(Web), 85th, 2T08-09 (WEB ONLY) 2012 日本語 公開
Oliver Beckstein, Tatsuro Shimamura, Simone Weyand, Nicholas G. Rutherford, Jonathan M. Hadden, David Sharples, So Iwata, Peter J. F. Henderson, Alexander D. Cameron, Mark S. P. Sansom Oliver Beckstein, Tatsuro Shimamura, Simone Weyand, Nicholas G. Rutherford, Jonathan M. Hadden, David Sharples, So Iwata, Peter J. F. Henderson, Alexander D. Cameron, Mark S. P. Sansom Oliver Beckstein, Tatsuro Shimamura, Simone Weyand, Nicholas G. Rutherford, Jonathan M. Hadden, David Sharples, So Iwata, Peter J. F. Henderson, Alexander D. Cameron, Mark S. P. Sansom Molecular Basis of the "Alternate Access Model" in the Cation-Substrate Symporter Mhp1 from Computer Simulations and X-Ray Crystallography Molecular Basis of the "Alternate Access Model" in the Cation-Substrate Symporter Mhp1 from Computer Simulations and X-Ray Crystallography Molecular Basis of the "Alternate Access Model" in the Cation-Substrate Symporter Mhp1 from Computer Simulations and X-Ray Crystallography BIOPHYSICAL JOURNAL, 98, 3, 628A-628A BIOPHYSICAL JOURNAL, 98, 3, 628A-628A BIOPHYSICAL JOURNAL, 98, 3, 628A-628A 2010/01 英語 研究発表ペーパー要旨(国際会議) 公開
タイトル言語:
講演・口頭発表等
タイトル タイトル(日本語) タイトル(英語) 会議名 会議名(日本語) 会議名(英語) 主催者 主催者(日本語) 主催者(英語) 発表年月日 記述言語 会議種別 公開
Serial Femtosecond crystallography using LCP crystals at SACLA[招待あり] Serial Femtosecond crystallography using LCP crystals at SACLA [招待あり] Serial Femtosecond crystallography using LCP crystals at SACLA [招待あり] AsCA 2018/CRYSTAL 32 AsCA 2018/CRYSTAL 32 AsCA 2018/CRYSTAL 32 The Asian Crystallographic Association The Asian Crystallographic Association 2018/12/02 英語 シンポジウム・ワークショップパネル(指名) 公開
Structure of the human histamine H1 receptor with doxepin.[招待あり] Structure of the human histamine H1 receptor with doxepin. [招待あり] Structure of the human histamine H1 receptor with doxepin. [招待あり] International Union of Crystallography, XXII Congress and General Assembly. International Union of Crystallography, XXII Congress and General Assembly. International Union of Crystallography, XXII Congress and General Assembly. 2011/08/29 英語 口頭発表(招待・特別) 公開
タイトル言語:
産業財産権 (特許)
発明者 発明者(日本語) 発明者(英語) 発明の名称 発明の名称(日本語) 発明の名称(英語) 審査の段階 番号 年月 公開
小笠原 諭, 日野 智也, 島村 達郎, 荒川 孝俊, 万木 貴美, 寿野 千代, 村田 武士, 小林 拓也, 岩田 想 小笠原 諭, 日野 智也, 島村 達郎, 荒川 孝俊, 万木 貴美, 寿野 千代, 村田 武士, 小林 拓也, 岩田 想 アゴニストの親和性を亢進する抗ヒトアデノシンA2a受容体モノクローナル抗体 アゴニストの親和性を亢進する抗ヒトアデノシンA2a受容体モノクローナル抗体 特許登録 特許第5750700号 2015/05/29 公開
小笠原 諭, 日野 智也, 島村 達郎, 荒川 孝俊, 万木 貴美, 寿野 千代, 村田 武士, 小林 拓也, 岩田 想 小笠原 諭, 日野 智也, 島村 達郎, 荒川 孝俊, 万木 貴美, 寿野 千代, 村田 武士, 小林 拓也, 岩田 想 アゴニストの親和性を亢進する抗ヒトアデノシンA2a受容体モノクローナル抗体 アゴニストの親和性を亢進する抗ヒトアデノシンA2a受容体モノクローナル抗体 特許公開 特開2013-183660 2013/09/19 公開
タイトル言語:
外部資金：競争的資金 (科学研究費補助金)
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
基盤研究（Ｂ） 代表 Ｘ線結晶構造解析による核酸塩基ー陽イオン共輸送体の輸送機構の解明 2009/04/01〜2012/03/31
新学術領域研究（研究領域提案型） 代表 アロステリック抗体を用いたアデノシン受容体の構造解析 2012/04/01〜2014/03/31
基盤研究（Ｂ） 代表 次世代抗ヒスタミン薬の開発に役立つヒスタミン受容体の構造解析　　　　　　　　　　 2012/04/01〜2015/03/31
挑戦的萌芽研究 代表 ヒト由来膜輸送体の結晶構造解析への挑戦 2013〜2014
挑戦的萌芽研究 代表 ヒト由来膜輸送体の結晶構造解析への挑戦 （平成26年度分） 2014/04/01〜2015/03/31
新学術領域研究（研究領域提案型） 代表 立体構造に基づくGPCRとリガンドの相互作用の解明 （平成26年度分） 2014/04/01〜2015/03/31
基盤研究（Ｂ） 代表 G蛋白質非依存的な情報伝達を行い、抗癌剤の標的であるケモカイン受容体の構造解析 （平成27年度分） 2015/04/01〜2016/03/31
新学術領域研究（研究領域提案型） 代表 立体構造に基づくGPCRとリガンドの相互作用の解明 （平成27年度分） 2015/04/01〜2016/03/31
基盤研究(B) 代表 G蛋白質非依存的な情報伝達を行い、抗癌剤の標的であるケモカイン受容体の構造解析 （平成28年度分） 2016/04/01〜2017/03/31
挑戦的研究（萌芽） 代表 分子量の小さいGPCRのクライオ電子顕微鏡を用いた単粒子解析の挑戦 （平成29年度分） 2017/04/01〜2018/03/31
基盤研究(B) 代表 G蛋白質非依存的な情報伝達を行い、抗癌剤の標的であるケモカイン受容体の構造解析 （平成29年度分） 2017/04/01〜2018/03/31
挑戦的研究（萌芽） 代表 分子量の小さいGPCRのクライオ電子顕微鏡を用いた単粒子解析の挑戦 （平成30年度分） 2018/04/01〜2019/03/31
基盤研究(B) 代表 GPCRのバイアス型シグナル機構の構造基盤 （平成30年度分） 2018/04/01〜2019/03/31
基盤研究(B) 代表 GPCRのバイアス型シグナル機構の構造基盤 （2019年度分） 2019/04/01〜2020/03/31
挑戦的研究（萌芽） 代表 分子量の小さいGPCRのクライオ電子顕微鏡を用いた単粒子解析の挑戦 （2019年度分） 2019/04/01〜2020/03/31

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担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
タンパク質のかたちを観る／生命現象を観る Direct observation of the protein shape and life phenomenon 前期 全学共通科目 2012/04〜2013/03

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