松原 淳一

最終更新日時: 2021/06/01 13:46:48

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氏名(漢字/フリガナ/アルファベット表記)
松原 淳一/マツバラ ジユンイチ/Matsubara, Junichi
所属部署・職名(部局/所属/講座等/職名)
医学研究科/医学専攻内科学講座腫瘍薬物治療学/講師
学部兼担
部局 所属 講座等 職名
医学部
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
博士(医学) 京都大学
使用言語
言語名(japanese) 言語名(english) コード
英語 English eng
日本語 Japanese jpn
researchmap URL
https://researchmap.jp/junichimatsubara
研究テーマ
(日本語)
がん化学療法の個別化マーカーの開発 細胞周期応答に関わる分子の機能解析に基づく新しい創薬ターゲットの探索
(英語)
Biomarker study to enhance the personalized cancer chemotherapy. Functional analysis of the molecules involved in the DNA-damaging response and cell-cycle arrest.
研究概要
(日本語)
消化器がん化学療法における治療個別化マーカーの開発を目指し、ヒト検体を用いた様々な研究を行っている。 細胞周期停止応答とDNA損傷修復機構に関わる分子の中で、細胞周期停止応答を担う分子を阻害して抗がん剤による殺細胞効果を高める臨床データが最近報告されている。われわれは、これまで阻害剤が開発されていないある細胞周期停止応答タンパクに着目し、in silico解析による新しい化合物のスクリーニング、およびその化合物と抗がん剤の併用相乗効果のin vitro / in vivo validationを行い、新しい抗がん治療戦略の確立を目指して研究を行っている。
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
胃癌 Gastric Cancer
大腸癌 Colon Cancer
膵癌 Pancreatic Cancer
抗がん剤 Chemotherapy
バイオマーカー Biomarker
がん幹細胞 Cancer Stem Cell
治療抵抗性 Chemotherapy Resistance
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Yoshioka M, Ohashi S, Ida T, Nakai Y, Kikuchi O, Amanuma Y, Matsubara J, Yamada A, Miyamoto S, Natsuizaka M, Nakagawa H, Chiba T, Seno H, Muto M Yoshioka M, Ohashi S, Ida T, Nakai Y, Kikuchi O, Amanuma Y, Matsubara J, Yamada A, Miyamoto S, Natsuizaka M, Nakagawa H, Chiba T, Seno H, Muto M Yoshioka M, Ohashi S, Ida T, Nakai Y, Kikuchi O, Amanuma Y, Matsubara J, Yamada A, Miyamoto S, Natsuizaka M, Nakagawa H, Chiba T, Seno H, Muto M Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells. Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells. Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells. Journal of experimental & clinical cancer research : CR, 36, 1, 101 Journal of experimental & clinical cancer research : CR, 36, 1, 101 Journal of experimental & clinical cancer research : CR, 36, 1, 101 2017/08 公開
Junichi Matsubara, Kazufumi Honda, Masaya Ono, Shigeki Sekine, Yoshinori Tanaka, Michimoto Kobayashi, Giman Jung, Tomohiro Sakuma, Shoji Nakamori, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Takuji Okusaka, Tomoo Kosuge, Akihiko Tsuchida, Masashi Shimahara, Yohichi Yasunami, Tsutomu Chiba, Tesshi Yamada Junichi Matsubara, Kazufumi Honda, Masaya Ono, Shigeki Sekine, Yoshinori Tanaka, Michimoto Kobayashi, Giman Jung, Tomohiro Sakuma, Shoji Nakamori, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Takuji Okusaka, Tomoo Kosuge, Akihiko Tsuchida, Masashi Shimahara, Yohichi Yasunami, Tsutomu Chiba, Tesshi Yamada Junichi Matsubara, Kazufumi Honda, Masaya Ono, Shigeki Sekine, Yoshinori Tanaka, Michimoto Kobayashi, Giman Jung, Tomohiro Sakuma, Shoji Nakamori, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Takuji Okusaka, Tomoo Kosuge, Akihiko Tsuchida, Masashi Shimahara, Yohichi Yasunami, Tsutomu Chiba, Tesshi Yamada Identification of Adipophilin as a Potential Plasma Biomarker for Colorectal Cancer Using Label-Free Quantitative Mass Spectrometry and Protein Microarray Identification of Adipophilin as a Potential Plasma Biomarker for Colorectal Cancer Using Label-Free Quantitative Mass Spectrometry and Protein Microarray Identification of Adipophilin as a Potential Plasma Biomarker for Colorectal Cancer Using Label-Free Quantitative Mass Spectrometry and Protein Microarray CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 20, 10, 2195-2203 CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 20, 10, 2195-2203 CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 20, 10, 2195-2203 2011/10 英語 研究論文(学術雑誌) 公開
Natsuko Tsuda Okita, Ken Kato, Daisuke Takahari, Yoshinori Hirashima, Takako E. Nakajima, Junichi Matsubara, Tetsuya Hamaguchi, Yasuhide Yamada, Yasuhiro Shimada, Hirokazu Taniguchi, Kuniaki Shirao Natsuko Tsuda Okita, Ken Kato, Daisuke Takahari, Yoshinori Hirashima, Takako E. Nakajima, Junichi Matsubara, Tetsuya Hamaguchi, Yasuhide Yamada, Yasuhiro Shimada, Hirokazu Taniguchi, Kuniaki Shirao Natsuko Tsuda Okita, Ken Kato, Daisuke Takahari, Yoshinori Hirashima, Takako E. Nakajima, Junichi Matsubara, Tetsuya Hamaguchi, Yasuhide Yamada, Yasuhiro Shimada, Hirokazu Taniguchi, Kuniaki Shirao Neuroendocrine tumors of the stomach: chemotherapy with cisplatin plus irinotecan is effective for gastric poorly-differentiated neuroendocrine carcinoma Neuroendocrine tumors of the stomach: chemotherapy with cisplatin plus irinotecan is effective for gastric poorly-differentiated neuroendocrine carcinoma Neuroendocrine tumors of the stomach: chemotherapy with cisplatin plus irinotecan is effective for gastric poorly-differentiated neuroendocrine carcinoma GASTRIC CANCER, 14, 2, 161-165 GASTRIC CANCER, 14, 2, 161-165 GASTRIC CANCER, 14, 2, 161-165 2011/06 英語 研究論文(学術雑誌) 公開
Yusuke Murakoshi, Kazufumi Honda, Shizuka Sasazuki, Masaya Ono, Ayako Negishi, Junichi Matsubara, Tomohiro Sakuma, Hideya Kuwabara, Shoji Nakamori, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Takuji Okusaka, Tomoo Kosuge, Masashi Shimahara, Yohichi Yasunami, Yoshinori Ino, Akihiko Tsuchida, Tatsuya Aoki, Shoichiro Tsugane, Tesshi Yamada Yusuke Murakoshi, Kazufumi Honda, Shizuka Sasazuki, Masaya Ono, Ayako Negishi, Junichi Matsubara, Tomohiro Sakuma, Hideya Kuwabara, Shoji Nakamori, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Takuji Okusaka, Tomoo Kosuge, Masashi Shimahara, Yohichi Yasunami, Yoshinori Ino, Akihiko Tsuchida, Tatsuya Aoki, Shoichiro Tsugane, Tesshi Yamada Yusuke Murakoshi, Kazufumi Honda, Shizuka Sasazuki, Masaya Ono, Ayako Negishi, Junichi Matsubara, Tomohiro Sakuma, Hideya Kuwabara, Shoji Nakamori, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Takuji Okusaka, Tomoo Kosuge, Masashi Shimahara, Yohichi Yasunami, Yoshinori Ino, Akihiko Tsuchida, Tatsuya Aoki, Shoichiro Tsugane, Tesshi Yamada Plasma biomarker discovery and validation for colorectal cancer by quantitative shotgun mass spectrometry and protein microarray Plasma biomarker discovery and validation for colorectal cancer by quantitative shotgun mass spectrometry and protein microarray Plasma biomarker discovery and validation for colorectal cancer by quantitative shotgun mass spectrometry and protein microarray CANCER SCIENCE, 102, 3, 630-638 CANCER SCIENCE, 102, 3, 630-638 CANCER SCIENCE, 102, 3, 630-638 2011/03 英語 研究論文(学術雑誌) 公開
Junichi Matsubara, Yasuhiro Shimada, Ken Kato, Yushi Nagai, Satoru Iwasa, Takako E. Nakajima, Tetsuya Hamaguchi, Yasuhide Yamada, Seiichi Takagi, Kazuma Kobayashi, Akira Yoshioka, Norisuke Nakayama, Akihito Tsuji Junichi Matsubara, Yasuhiro Shimada, Ken Kato, Yushi Nagai, Satoru Iwasa, Takako E. Nakajima, Tetsuya Hamaguchi, Yasuhide Yamada, Seiichi Takagi, Kazuma Kobayashi, Akira Yoshioka, Norisuke Nakayama, Akihito Tsuji Junichi Matsubara, Yasuhiro Shimada, Ken Kato, Yushi Nagai, Satoru Iwasa, Takako E. Nakajima, Tetsuya Hamaguchi, Yasuhide Yamada, Seiichi Takagi, Kazuma Kobayashi, Akira Yoshioka, Norisuke Nakayama, Akihito Tsuji Phase II Study of Bolus 5-Fluorouracil and Leucovorin Combined with Weekly Paclitaxel as First-Line Therapy for Advanced Gastric Cancer Phase II Study of Bolus 5-Fluorouracil and Leucovorin Combined with Weekly Paclitaxel as First-Line Therapy for Advanced Gastric Cancer Phase II Study of Bolus 5-Fluorouracil and Leucovorin Combined with Weekly Paclitaxel as First-Line Therapy for Advanced Gastric Cancer ONCOLOGY, 81, 5-6, 291-297 ONCOLOGY, 81, 5-6, 291-297 ONCOLOGY, 81, 5-6, 291-297 2011 英語 研究論文(学術雑誌) 公開
Akira Yokomizo, Michiko Takakura, Yae Kanai, Tomohiro Sakuma, Junichi Matsubara, Kazufumi Honda, Seiji Naito, Tesshi Yamada, Masaya Ono Akira Yokomizo, Michiko Takakura, Yae Kanai, Tomohiro Sakuma, Junichi Matsubara, Kazufumi Honda, Seiji Naito, Tesshi Yamada, Masaya Ono Akira Yokomizo, Michiko Takakura, Yae Kanai, Tomohiro Sakuma, Junichi Matsubara, Kazufumi Honda, Seiji Naito, Tesshi Yamada, Masaya Ono Use of quantitative shotgun proteomics to identify fibronectin 1 as a potential plasma biomarker for clear cell carcinoma of the kidney Use of quantitative shotgun proteomics to identify fibronectin 1 as a potential plasma biomarker for clear cell carcinoma of the kidney Use of quantitative shotgun proteomics to identify fibronectin 1 as a potential plasma biomarker for clear cell carcinoma of the kidney CANCER BIOMARKERS, 10, 3-4, 175-183 CANCER BIOMARKERS, 10, 3-4, 175-183 CANCER BIOMARKERS, 10, 3-4, 175-183 2011 英語 研究論文(学術雑誌) 公開
Junichi Matsubara, Kazufumi Honda, Masaya Ono, Yoshinori Tanaka, Michimoto Kobayashi, Giman Jung, Koji Yanagisawa, Tomohiro Sakuma, Shoji Nakamori, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Takuji Okusaka, Tomoo Kosuge, Akihiko Tsuchida, Masashi Shimahara, Yohichi Yasunami, Tsutomu Chiba, Setsuo Hirohashi, Tesshi Yamada Junichi Matsubara, Kazufumi Honda, Masaya Ono, Yoshinori Tanaka, Michimoto Kobayashi, Giman Jung, Koji Yanagisawa, Tomohiro Sakuma, Shoji Nakamori, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Takuji Okusaka, Tomoo Kosuge, Akihiko Tsuchida, Masashi Shimahara, Yohichi Yasunami, Tsutomu Chiba, Setsuo Hirohashi, Tesshi Yamada Junichi Matsubara, Kazufumi Honda, Masaya Ono, Yoshinori Tanaka, Michimoto Kobayashi, Giman Jung, Koji Yanagisawa, Tomohiro Sakuma, Shoji Nakamori, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Takuji Okusaka, Tomoo Kosuge, Akihiko Tsuchida, Masashi Shimahara, Yohichi Yasunami, Tsutomu Chiba, Setsuo Hirohashi, Tesshi Yamada Reduced Plasma Level of CXC Chemokine Ligand 7 in Patients with Pancreatic Cancer Reduced Plasma Level of CXC Chemokine Ligand 7 in Patients with Pancreatic Cancer Reduced Plasma Level of CXC Chemokine Ligand 7 in Patients with Pancreatic Cancer CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 20, 1, 160-171 CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 20, 1, 160-171 CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 20, 1, 160-171 2011/01 英語 研究論文(学術雑誌) 公開
松原 淳一, 平島 詳典, 山田 康秀 松原 淳一, 平島 詳典, 山田 康秀 胃がんにおけるHER2、EGFR、IGF-1R、VEGFRの発現と化学療法の治療成績 胃がんにおけるHER2、EGFR、IGF-1R、VEGFRの発現と化学療法の治療成績 癌と化学療法, 37, 8, 1489-1496 癌と化学療法, 37, 8, 1489-1496 , 37, 8, 1489-1496 2010/08 日本語 公開
Junichi Matsubara, Yoshinori Hirashima, Yasuhide Yamada Junichi Matsubara, Yoshinori Hirashima, Yasuhide Yamada Junichi Matsubara, Yoshinori Hirashima, Yasuhide Yamada [Impact of HER2, EGFR, IGF-1R, and VEGFR expressions on the outcome of chemotherapy for advanced gastric cancer]. [Impact of HER2, EGFR, IGF-1R, and VEGFR expressions on the outcome of chemotherapy for advanced gastric cancer]. [Impact of HER2, EGFR, IGF-1R, and VEGFR expressions on the outcome of chemotherapy for advanced gastric cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 37, 8, 1489-96 Gan to kagaku ryoho. Cancer & chemotherapy, 37, 8, 1489-96 Gan to kagaku ryoho. Cancer & chemotherapy, 37, 8, 1489-96 2010/08 日本語 研究論文(学術雑誌) 公開
Junichi Matsubara, Masaya Ono, Kazufumi Honda, Ayako Negishi, Hideki Ueno, Takuji Okusaka, Junji Furuse, Koh Furuta, Emiko Sugiyama, Yoshiro Saito, Nahoko Kaniwa, Junichi Sawada, Ayako Shoji, Tomohiro Sakuma, Tsutomu Chiba, Nagahiro Saijo, Setsuo Hirohashi, Tesshi Yamada Junichi Matsubara, Masaya Ono, Kazufumi Honda, Ayako Negishi, Hideki Ueno, Takuji Okusaka, Junji Furuse, Koh Furuta, Emiko Sugiyama, Yoshiro Saito, Nahoko Kaniwa, Junichi Sawada, Ayako Shoji, Tomohiro Sakuma, Tsutomu Chiba, Nagahiro Saijo, Setsuo Hirohashi, Tesshi Yamada Junichi Matsubara, Masaya Ono, Kazufumi Honda, Ayako Negishi, Hideki Ueno, Takuji Okusaka, Junji Furuse, Koh Furuta, Emiko Sugiyama, Yoshiro Saito, Nahoko Kaniwa, Junichi Sawada, Ayako Shoji, Tomohiro Sakuma, Tsutomu Chiba, Nagahiro Saijo, Setsuo Hirohashi, Tesshi Yamada Survival Prediction for Pancreatic Cancer Patients Receiving Gemcitabine Treatment Survival Prediction for Pancreatic Cancer Patients Receiving Gemcitabine Treatment Survival Prediction for Pancreatic Cancer Patients Receiving Gemcitabine Treatment MOLECULAR & CELLULAR PROTEOMICS, 9, 4, 695-704 MOLECULAR & CELLULAR PROTEOMICS, 9, 4, 695-704 MOLECULAR & CELLULAR PROTEOMICS, 9, 4, 695-704 2010/04 英語 研究論文(学術雑誌) 公開
Masaya Ono, Junichi Matsubara, Kazufumi Honda, Tomohiro Sakuma, Tomoyo Hashiguchi, Hiroshi Nose, Shoji Nakamori, Takuji Okusaka, Tomoo Kosuge, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Sachiko Tanaka, Akihiko Tsuchida, Tatsuya Aoki, Masashi Shimahara, Yohichi Yasunami, Takao Itoi, Fuminori Moriyasu, Ayako Negishi, Hideya Kuwabara, Ayako Shoji, Setsuo Hirohashi, Tesshi Yamada Masaya Ono, Junichi Matsubara, Kazufumi Honda, Tomohiro Sakuma, Tomoyo Hashiguchi, Hiroshi Nose, Shoji Nakamori, Takuji Okusaka, Tomoo Kosuge, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Sachiko Tanaka, Akihiko Tsuchida, Tatsuya Aoki, Masashi Shimahara, Yohichi Yasunami, Takao Itoi, Fuminori Moriyasu, Ayako Negishi, Hideya Kuwabara, Ayako Shoji, Setsuo Hirohashi, Tesshi Yamada Masaya Ono, Junichi Matsubara, Kazufumi Honda, Tomohiro Sakuma, Tomoyo Hashiguchi, Hiroshi Nose, Shoji Nakamori, Takuji Okusaka, Tomoo Kosuge, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Sachiko Tanaka, Akihiko Tsuchida, Tatsuya Aoki, Masashi Shimahara, Yohichi Yasunami, Takao Itoi, Fuminori Moriyasu, Ayako Negishi, Hideya Kuwabara, Ayako Shoji, Setsuo Hirohashi, Tesshi Yamada Prolyl 4-hydroxylation of α-fibrinogen. A novel protein modification revealed by plasma proteomics Prolyl 4-hydroxylation of α-fibrinogen. A novel protein modification revealed by plasma proteomics Prolyl 4-hydroxylation of α-fibrinogen. A novel protein modification revealed by plasma proteomics Journal of Biological Chemistry, 284, 42, 29041-29049 Journal of Biological Chemistry, 284, 42, 29041-29049 Journal of Biological Chemistry, 284, 42, 29041-29049 2009/10/16 英語 研究論文(学術雑誌) 公開
Natsuko Tsuda Okita, Yasuhide Yamada, Daisuke Takahari, Yosinori Hirashima, Junichi Matsubara, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Hirokazu Taniguchi, Tadakazu Shimoda Natsuko Tsuda Okita, Yasuhide Yamada, Daisuke Takahari, Yosinori Hirashima, Junichi Matsubara, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Hirokazu Taniguchi, Tadakazu Shimoda Natsuko Tsuda Okita, Yasuhide Yamada, Daisuke Takahari, Yosinori Hirashima, Junichi Matsubara, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Hirokazu Taniguchi, Tadakazu Shimoda Vascular Endothelial Growth Factor Receptor Expression as a Prognostic Marker for Survival in Colorectal Cancer Vascular Endothelial Growth Factor Receptor Expression as a Prognostic Marker for Survival in Colorectal Cancer Vascular Endothelial Growth Factor Receptor Expression as a Prognostic Marker for Survival in Colorectal Cancer JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 39, 9, 595-600 JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 39, 9, 595-600 JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 39, 9, 595-600 2009/09 英語 研究論文(学術雑誌) 公開
Junichi Matsubara, Masaya Ono, Ayako Negishi, Hideki Ueno, Takuji Okusaka, Junji Furuse, Koh Furuta, Emiko Sugiyama, Yoshiro Saito, Nahoko Kaniwa, Junichi Sawada, Kazufumi Honda, Tomohiro Sakuma, Tsutomu Chiba, Nagahiro Saijo, Setsuo Hirohashi, Tesshi Yamada Junichi Matsubara, Masaya Ono, Ayako Negishi, Hideki Ueno, Takuji Okusaka, Junji Furuse, Koh Furuta, Emiko Sugiyama, Yoshiro Saito, Nahoko Kaniwa, Junichi Sawada, Kazufumi Honda, Tomohiro Sakuma, Tsutomu Chiba, Nagahiro Saijo, Setsuo Hirohashi, Tesshi Yamada Junichi Matsubara, Masaya Ono, Ayako Negishi, Hideki Ueno, Takuji Okusaka, Junji Furuse, Koh Furuta, Emiko Sugiyama, Yoshiro Saito, Nahoko Kaniwa, Junichi Sawada, Kazufumi Honda, Tomohiro Sakuma, Tsutomu Chiba, Nagahiro Saijo, Setsuo Hirohashi, Tesshi Yamada Identification of a Predictive Biomarker for Hematologic Toxicities of Gemcitabine Identification of a Predictive Biomarker for Hematologic Toxicities of Gemcitabine Identification of a Predictive Biomarker for Hematologic Toxicities of Gemcitabine JOURNAL OF CLINICAL ONCOLOGY, 27, 13, 2261-2268 JOURNAL OF CLINICAL ONCOLOGY, 27, 13, 2261-2268 JOURNAL OF CLINICAL ONCOLOGY, 27, 13, 2261-2268 2009/05 英語 研究論文(学術雑誌) 公開
Yoshinori Hirashima, Yasuhide Yamada, Junichi Matsubara, Daisuke Takahari, Natsuko Okita, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Hirokazu Taniguchi, Tadakazu Shimoda Yoshinori Hirashima, Yasuhide Yamada, Junichi Matsubara, Daisuke Takahari, Natsuko Okita, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Hirokazu Taniguchi, Tadakazu Shimoda Yoshinori Hirashima, Yasuhide Yamada, Junichi Matsubara, Daisuke Takahari, Natsuko Okita, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Hirokazu Taniguchi, Tadakazu Shimoda Impact of vascular endothelial growth factor receptor 1, 2, and 3 expression on the outcome of patients with gastric cancer Impact of vascular endothelial growth factor receptor 1, 2, and 3 expression on the outcome of patients with gastric cancer Impact of vascular endothelial growth factor receptor 1, 2, and 3 expression on the outcome of patients with gastric cancer CANCER SCIENCE, 100, 2, 310-315 CANCER SCIENCE, 100, 2, 310-315 CANCER SCIENCE, 100, 2, 310-315 2009/02 英語 研究論文(学術雑誌) 公開
Daisuke Takahari, Yasuhide Yamada, Natuko T. Okita, Takuya Honda, Yoshinori Hirashima, Junichi Matsubara, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Tadakazu Shimoda Daisuke Takahari, Yasuhide Yamada, Natuko T. Okita, Takuya Honda, Yoshinori Hirashima, Junichi Matsubara, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Tadakazu Shimoda Daisuke Takahari, Yasuhide Yamada, Natuko T. Okita, Takuya Honda, Yoshinori Hirashima, Junichi Matsubara, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Tadakazu Shimoda Relationships of Insulin-Like Growth Factor-1 Receptor and Epidermal Growth Factor Receptor Expression to Clinical Outcomes in Patients with Colorectal Cancer Relationships of Insulin-Like Growth Factor-1 Receptor and Epidermal Growth Factor Receptor Expression to Clinical Outcomes in Patients with Colorectal Cancer Relationships of Insulin-Like Growth Factor-1 Receptor and Epidermal Growth Factor Receptor Expression to Clinical Outcomes in Patients with Colorectal Cancer ONCOLOGY, 76, 1, 42-48 ONCOLOGY, 76, 1, 42-48 ONCOLOGY, 76, 1, 42-48 2009 英語 研究論文(学術雑誌) 公開
Junichi Matsubara, Yasuhiro Shimada, Atsuo Takashima, Daisuke Takahari, Yoshinori Hirashima, Natsuko T. Okita, Takako E. Nakajima, Ken Kato, Tetsuya Hamaguchi, Yasuhide Yamada, Kuniaki Shirao Junichi Matsubara, Yasuhiro Shimada, Atsuo Takashima, Daisuke Takahari, Yoshinori Hirashima, Natsuko T. Okita, Takako E. Nakajima, Ken Kato, Tetsuya Hamaguchi, Yasuhide Yamada, Kuniaki Shirao Junichi Matsubara, Yasuhiro Shimada, Atsuo Takashima, Daisuke Takahari, Yoshinori Hirashima, Natsuko T. Okita, Takako E. Nakajima, Ken Kato, Tetsuya Hamaguchi, Yasuhide Yamada, Kuniaki Shirao A phase I study of bolus 5-fluorouracil and leucovorin combined with weekly paclitaxel (FLTAX) as first-line therapy for advanced gastric cancer A phase I study of bolus 5-fluorouracil and leucovorin combined with weekly paclitaxel (FLTAX) as first-line therapy for advanced gastric cancer A phase I study of bolus 5-fluorouracil and leucovorin combined with weekly paclitaxel (FLTAX) as first-line therapy for advanced gastric cancer JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 38, 8, 540-546 JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 38, 8, 540-546 JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 38, 8, 540-546 2008/08 英語 研究論文(学術雑誌) 公開
Junichi Matsubara, Yasuhide Yamada, Yoshinori Hirashima, Daisuke Takahari, Natsuko T. Okita, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Tadakazu Shimoda Junichi Matsubara, Yasuhide Yamada, Yoshinori Hirashima, Daisuke Takahari, Natsuko T. Okita, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Tadakazu Shimoda Junichi Matsubara, Yasuhide Yamada, Yoshinori Hirashima, Daisuke Takahari, Natsuko T. Okita, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Tadakazu Shimoda Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer CLINICAL CANCER RESEARCH, 14, 10, 3022-3029 CLINICAL CANCER RESEARCH, 14, 10, 3022-3029 CLINICAL CANCER RESEARCH, 14, 10, 3022-3029 2008/05 英語 研究論文(学術雑誌) 公開
Junichi Matsubara, Takuji Okusaka, Chigusa Morizane, Masafumi Ikeda, Hideki Ueno Junichi Matsubara, Takuji Okusaka, Chigusa Morizane, Masafumi Ikeda, Hideki Ueno Junichi Matsubara, Takuji Okusaka, Chigusa Morizane, Masafumi Ikeda, Hideki Ueno Ultrasound-guided percutaneous pancreatic tumor biopsy in pancreatic cancer: a comparison with metastatic liver tumor biopsy, including sensitivity, specificity, and complications Ultrasound-guided percutaneous pancreatic tumor biopsy in pancreatic cancer: a comparison with metastatic liver tumor biopsy, including sensitivity, specificity, and complications Ultrasound-guided percutaneous pancreatic tumor biopsy in pancreatic cancer: a comparison with metastatic liver tumor biopsy, including sensitivity, specificity, and complications JOURNAL OF GASTROENTEROLOGY, 43, 3, 225-232 JOURNAL OF GASTROENTEROLOGY, 43, 3, 225-232 JOURNAL OF GASTROENTEROLOGY, 43, 3, 225-232 2008/03 英語 研究論文(学術雑誌) 公開
Takako Eguchi Nakajima, Yasuhide Yamada, Tadakazu Shimoda, Junichi Matsubara, Ken Kato, Tetsuya Hamaguchi, Yasuhiro Shimada, Yoshihiro Okayama, Toshinori Oka, Kuniaki Shirao Takako Eguchi Nakajima, Yasuhide Yamada, Tadakazu Shimoda, Junichi Matsubara, Ken Kato, Tetsuya Hamaguchi, Yasuhiro Shimada, Yoshihiro Okayama, Toshinori Oka, Kuniaki Shirao Takako Eguchi Nakajima, Yasuhide Yamada, Tadakazu Shimoda, Junichi Matsubara, Ken Kato, Tetsuya Hamaguchi, Yasuhiro Shimada, Yoshihiro Okayama, Toshinori Oka, Kuniaki Shirao Combination of O-6-methylguanine-DNA methyltransferase and thymidylate synthase for the prediction of fluoropyrimidine efficacy Combination of O-6-methylguanine-DNA methyltransferase and thymidylate synthase for the prediction of fluoropyrimidine efficacy Combination of O-6-methylguanine-DNA methyltransferase and thymidylate synthase for the prediction of fluoropyrimidine efficacy EUROPEAN JOURNAL OF CANCER, 44, 3, 400-407 EUROPEAN JOURNAL OF CANCER, 44, 3, 400-407 EUROPEAN JOURNAL OF CANCER, 44, 3, 400-407 2008/02 英語 研究論文(学術雑誌) 公開
J. Matsubara, T. Nishina, Y. Yamada, T. Moriwaki, T. Shimoda, T. Kajiwara, T. E. Nakajima, K. Kato, T. Hamaguchi, Y. Shimada, Y. Okayama, T. Oka, K. Shirao J. Matsubara, T. Nishina, Y. Yamada, T. Moriwaki, T. Shimoda, T. Kajiwara, T. E. Nakajima, K. Kato, T. Hamaguchi, Y. Shimada, Y. Okayama, T. Oka, K. Shirao J. Matsubara, T. Nishina, Y. Yamada, T. Moriwaki, T. Shimoda, T. Kajiwara, T. E. Nakajima, K. Kato, T. Hamaguchi, Y. Shimada, Y. Okayama, T. Oka, K. Shirao Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer BRITISH JOURNAL OF CANCER, 98, 4, 832-839 BRITISH JOURNAL OF CANCER, 98, 4, 832-839 BRITISH JOURNAL OF CANCER, 98, 4, 832-839 2008/02 英語 研究論文(学術雑誌) 公開
Junichi Matsubara, Yasuhide Yamada, Takako E. Nakajima, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Tadakazu Shimoda Junichi Matsubara, Yasuhide Yamada, Takako E. Nakajima, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Tadakazu Shimoda Junichi Matsubara, Yasuhide Yamada, Takako E. Nakajima, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Tadakazu Shimoda Clinical significance of insulin-like growth factor type 1 receptor and epidermal growth factor receptor in patients with advanced gastric cancer Clinical significance of insulin-like growth factor type 1 receptor and epidermal growth factor receptor in patients with advanced gastric cancer Clinical significance of insulin-like growth factor type 1 receptor and epidermal growth factor receptor in patients with advanced gastric cancer ONCOLOGY, 74, 1-2, 76-83 ONCOLOGY, 74, 1-2, 76-83 ONCOLOGY, 74, 1-2, 76-83 2008 英語 研究論文(学術雑誌) 公開
A. Takashima, K. Shirao, Y. Hirashima, D. Takahari, N. Okita, S. Akatsuka, T. Eguchi Nakajima, J. Matsubara, H. Yasui, T. Asakawa, K. Kato, T. Hamguchi, K. Muro, Y. Yamada, Y. Shimada A. Takashima, K. Shirao, Y. Hirashima, D. Takahari, N. Okita, S. Akatsuka, T. Eguchi Nakajima, J. Matsubara, H. Yasui, T. Asakawa, K. Kato, T. Hamguchi, K. Muro, Y. Yamada, Y. Shimada A. Takashima, K. Shirao, Y. Hirashima, D. Takahari, N. Okita, S. Akatsuka, T. Eguchi Nakajima, J. Matsubara, H. Yasui, T. Asakawa, K. Kato, T. Hamguchi, K. Muro, Y. Yamada, Y. Shimada Chemosensitivity of patients with recurrent esophageal cancer receiving perioperative chemotherapy Chemosensitivity of patients with recurrent esophageal cancer receiving perioperative chemotherapy Chemosensitivity of patients with recurrent esophageal cancer receiving perioperative chemotherapy DISEASES OF THE ESOPHAGUS, 21, 7, 607-611 DISEASES OF THE ESOPHAGUS, 21, 7, 607-611 DISEASES OF THE ESOPHAGUS, 21, 7, 607-611 2008 英語 研究論文(学術雑誌) 公開
松原 淳一, 島田 安博, 高島 淳生, 高張 大亮, 平島 詳典, 沖田 南都子, 中島 貴子, 加藤 健, 濱口 哲弥, 山田 康秀, 白尾 国昭 松原 淳一, 島田 安博, 高島 淳生, 高張 大亮, 平島 詳典, 沖田 南都子, 中島 貴子, 加藤 健, 濱口 哲弥, 山田 康秀, 白尾 国昭 切除不能・再発胃癌に対する5-FU+/-LV+Paclitaxel併用療法(FLTAX)の第I相試験 切除不能・再発胃癌に対する5-FU+/-LV+Paclitaxel併用療法(FLTAX)の第I相試験 日本癌治療学会誌, 42, 2, 422-422 日本癌治療学会誌, 42, 2, 422-422 , 42, 2, 422-422 2007/09 日本語 公開
Hideki Ueno, Takuji Okusaka, Masafumi Ikeda, Yoriko Ishiguro, Chigusa Morizane, Junichi Matsubara, Junji Furuse, Hiroshi Ishii, Michitaka Nagase, Kohei Nakachi Hideki Ueno, Takuji Okusaka, Masafumi Ikeda, Yoriko Ishiguro, Chigusa Morizane, Junichi Matsubara, Junji Furuse, Hiroshi Ishii, Michitaka Nagase, Kohei Nakachi Hideki Ueno, Takuji Okusaka, Masafumi Ikeda, Yoriko Ishiguro, Chigusa Morizane, Junichi Matsubara, Junji Furuse, Hiroshi Ishii, Michitaka Nagase, Kohei Nakachi A phase I study of combination chemotherapy with gemcitabine and oral S-1 for advanced pancreatic cancer. A phase I study of combination chemotherapy with gemcitabine and oral S-1 for advanced pancreatic cancer. A phase I study of combination chemotherapy with gemcitabine and oral S-1 for advanced pancreatic cancer. Oncology, 69, 5, 421-7 Oncology, 69, 5, 421-7 Oncology, 69, 5, 421-7 2005 英語 研究論文(学術雑誌) 公開

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タイトル言語:
Misc
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Masahiro Yoshioka, Shinya Ohashi, Tomomi Ida, Yukie Nakai, Osamu Kikuchi, Yusuke Amanuma, Junichi Matsubara, Atsushi Yamada, Shin'ichi Miyamoto, Mitsuteru Natsuizaka, Hiroshi Nakagawa, Tsutomu Chiba, Hiroshi Seno, Manabu Muto Masahiro Yoshioka, Shinya Ohashi, Tomomi Ida, Yukie Nakai, Osamu Kikuchi, Yusuke Amanuma, Junichi Matsubara, Atsushi Yamada, Shin'ichi Miyamoto, Mitsuteru Natsuizaka, Hiroshi Nakagawa, Tsutomu Chiba, Hiroshi Seno, Manabu Muto Masahiro Yoshioka, Shinya Ohashi, Tomomi Ida, Yukie Nakai, Osamu Kikuchi, Yusuke Amanuma, Junichi Matsubara, Atsushi Yamada, Shin'ichi Miyamoto, Mitsuteru Natsuizaka, Hiroshi Nakagawa, Tsutomu Chiba, Hiroshi Seno, Manabu Muto Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 36 JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 36 JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 36 2017/08 英語 公開
Junichi Matsubara, Masaya Ono, Hideki Ueno, Takuji Okusaka, Junji Furuse, Koh Furuta, Emiko Sugiyama, Yoshiro Saito, Nahoko Kaniwa, Junichi Sawada, Tomohiro Sakuma, Tsutomu Chiba, Nagahiro Saijo, Tesshi Yamada Junichi Matsubara, Masaya Ono, Hideki Ueno, Takuji Okusaka, Junji Furuse, Koh Furuta, Emiko Sugiyama, Yoshiro Saito, Nahoko Kaniwa, Junichi Sawada, Tomohiro Sakuma, Tsutomu Chiba, Nagahiro Saijo, Tesshi Yamada Junichi Matsubara, Masaya Ono, Hideki Ueno, Takuji Okusaka, Junji Furuse, Koh Furuta, Emiko Sugiyama, Yoshiro Saito, Nahoko Kaniwa, Junichi Sawada, Tomohiro Sakuma, Tsutomu Chiba, Nagahiro Saijo, Tesshi Yamada Predictive biomarker for hematological toxicities of gemcitabine identified by proteomics Predictive biomarker for hematological toxicities of gemcitabine identified by proteomics Predictive biomarker for hematological toxicities of gemcitabine identified by proteomics CANCER RESEARCH, 69 CANCER RESEARCH, 69 CANCER RESEARCH, 69 2009/05 英語 研究発表ペーパー要旨(国際会議) 公開
H. Kawakami, Y. Yamada, Y. Hirashima, D. Takahari, N. Tsuda, J. Matsubara, K. Kato, T. Hamaguchi, Y. Shimada, K. Shirao H. Kawakami, Y. Yamada, Y. Hirashima, D. Takahari, N. Tsuda, J. Matsubara, K. Kato, T. Hamaguchi, Y. Shimada, K. Shirao H. Kawakami, Y. Yamada, Y. Hirashima, D. Takahari, N. Tsuda, J. Matsubara, K. Kato, T. Hamaguchi, Y. Shimada, K. Shirao Retrospective study of the correlation between creatinine clearance and oxaliplatin-related cumulative neurotoxicity Retrospective study of the correlation between creatinine clearance and oxaliplatin-related cumulative neurotoxicity Retrospective study of the correlation between creatinine clearance and oxaliplatin-related cumulative neurotoxicity ANNALS OF ONCOLOGY, 18, VII79-VII79 ANNALS OF ONCOLOGY, 18, VII79-VII79 ANNALS OF ONCOLOGY, 18, VII79-VII79 2007 英語 研究発表ペーパー要旨(国際会議) 公開
J. Matsubara, Y. Yamada, T. Shimoda, T. Eguchi, T. Hamaguchi, Y. Shimada, Y. Okayama, Y. Sugimoto, T. Oka, K. Shirao J. Matsubara, Y. Yamada, T. Shimoda, T. Eguchi, T. Hamaguchi, Y. Shimada, Y. Okayama, Y. Sugimoto, T. Oka, K. Shirao J. Matsubara, Y. Yamada, T. Shimoda, T. Eguchi, T. Hamaguchi, Y. Shimada, Y. Okayama, Y. Sugimoto, T. Oka, K. Shirao Impact of dihydrofolate reductase (DHFR) and thymidylate synthase (TS) on outcomes of postoperative patients with gastric cancer. Impact of dihydrofolate reductase (DHFR) and thymidylate synthase (TS) on outcomes of postoperative patients with gastric cancer. Impact of dihydrofolate reductase (DHFR) and thymidylate synthase (TS) on outcomes of postoperative patients with gastric cancer. JOURNAL OF CLINICAL ONCOLOGY, 24, 18, 191S-191S JOURNAL OF CLINICAL ONCOLOGY, 24, 18, 191S-191S JOURNAL OF CLINICAL ONCOLOGY, 24, 18, 191S-191S 2006/06 英語 研究発表ペーパー要旨(国際会議) 公開
タイトル言語:
学術賞等
賞の名称(日本語) 賞の名称(英語) 授与組織名(日本語) 授与組織名(英語) 年月
AACR-ITO EN, Ltd. Scholar-in-Training Award アメリカ癌学会 American Association for Cancer Research 2009/04/01
日本プロテオーム学会 奨励賞 The Incitement Award of the Japanese Proteomics Society 日本プロテオーム学会 2010/09/01
外部資金:競争的資金 (科学研究費補助金)
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
日本学術振興会 特別研究員-PD 代表 新しいプロテオミクス解析アルゴリズムによる癌化学療法の新規バイオマーカー開発 2011/04/01〜2013/04/30
研究活動スタート支援 代表 大腸癌幹細胞と上皮間葉転換大腸癌細胞に共通する抗癌剤治療抵抗性メカニズムの解明 2017/04/01〜2018/03/31
科学研究費助成事業 基盤研究(C)(一般) 代表 大腸癌の抗癌剤耐性機序に関わるCDKN3を標的とした新規薬剤及び治療法開発 2019/04/01〜2022/03/31
基盤研究(C) 代表 大腸癌の抗癌剤耐性機序に関わるCDKN3を標的とした新規薬剤及び治療法開発 (2019年度分) 2019/04/01〜2020/03/31
基盤研究(C) 代表 大腸癌の抗癌剤耐性機序に関わるCDKN3を標的とした新規薬剤及び治療法開発 (2020年度分) 2020/04/01〜2021/03/31
外部資金:競争的資金 (科学研究費補助金以外)
制度名 代表者名 研究課題(日本語) 研究課題(英語) 期間
平成22年度安田記念医学財団 若手癌研究助成 松原 淳一 血液プロテオミクス解析を用いた大腸癌分子標的治療の個別化に関する新しい血中ペプチドマーカーの開発と臨床応用 2010/12/01〜2011/11/30
公益財団法人 武田科学振興財団 2011年度医学系研究奨励 松原 淳一 膵癌転移機序に関わる癌幹細胞由来タンパクの新規同定とその制御による新しい膵癌治療法の開発 2011/11/01〜
平成24年度上原記念生命科学財団 海外留学助成金リサーチフェローシップ 松原 淳一 癌幹細胞の薬物耐性機序解明と治療標的開発 2013/05/01〜2014/04/30