井上 詞貴

最終更新日時: 2021/06/02 16:43:44

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氏名(漢字/フリガナ/アルファベット表記)
井上 詞貴/イノウエ フミタカ/Inoue, Fumitaka
所属部署・職名(部局/所属/講座等/職名)
高等研究院/ヒト生物学高等研究拠点/特定准教授
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士(理学) 埼玉大学
博士(理学) 埼玉大学
使用言語
言語名(japanese) 言語名(english) コード
日本語 Japanese jpn
英語 English eng
ORCID ID
https://orcid.org/0000-0003-0657-434X
researchmap URL
https://researchmap.jp/fumitakainoue
研究テーマ
(日本語)
細胞分化・個体発生・進化に関わるレギュロームの理解
(英語)
Understanding human regulome that underlies cell differentiation, development and evolution
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
ゲノミクス Genomics
分子生物学 Molecular biology
発生生物学 Developmental biology
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Carly V Weiss, Lana Harshman, Fumitaka Inoue, Hunter B Fraser, Dmitri A Petrov, Nadav Ahituv, David Gokhman Carly V Weiss, Lana Harshman, Fumitaka Inoue, Hunter B Fraser, Dmitri A Petrov, Nadav Ahituv, David Gokhman Carly V Weiss, Lana Harshman, Fumitaka Inoue, Hunter B Fraser, Dmitri A Petrov, Nadav Ahituv, David Gokhman The cis-regulatory effects of modern human-specific variants. The cis-regulatory effects of modern human-specific variants. The cis-regulatory effects of modern human-specific variants. eLife, 10 eLife, 10 eLife, 10 2021/04/22 英語 研究論文(学術雑誌) 公開
Jason C. Klein, Vikram Agarwal, Fumitaka Inoue, Aidan Keith, Beth Martin, Martin Kircher, Nadav Ahituv, Jay Shendure Jason C. Klein, Vikram Agarwal, Fumitaka Inoue, Aidan Keith, Beth Martin, Martin Kircher, Nadav Ahituv, Jay Shendure Jason C. Klein, Vikram Agarwal, Fumitaka Inoue, Aidan Keith, Beth Martin, Martin Kircher, Nadav Ahituv, Jay Shendure A systematic evaluation of the design and context dependencies of massively parallel reporter assays A systematic evaluation of the design and context dependencies of massively parallel reporter assays A systematic evaluation of the design and context dependencies of massively parallel reporter assays Nature Methods Nature Methods Nature Methods 2020/10/12 研究論文(学術雑誌) 公開
M. Grace Gordon, Fumitaka Inoue, Beth Martin, Max Schubach, Vikram Agarwal, Sean Whalen, Shiyun Feng, Jingjing Zhao, Tal Ashuach, Ryan Ziffra, Anat Kreimer, Ilias Georgakopoulous-Soares, Nir Yosef, Chun Jimmie Ye, Katherine S. Pollard, Jay Shendure, Martin Kircher, Nadav Ahituv M. Grace Gordon, Fumitaka Inoue, Beth Martin, Max Schubach, Vikram Agarwal, Sean Whalen, Shiyun Feng, Jingjing Zhao, Tal Ashuach, Ryan Ziffra, Anat Kreimer, Ilias Georgakopoulous-Soares, Nir Yosef, Chun Jimmie Ye, Katherine S. Pollard, Jay Shendure, Martin Kircher, Nadav Ahituv M. Grace Gordon, Fumitaka Inoue, Beth Martin, Max Schubach, Vikram Agarwal, Sean Whalen, Shiyun Feng, Jingjing Zhao, Tal Ashuach, Ryan Ziffra, Anat Kreimer, Ilias Georgakopoulous-Soares, Nir Yosef, Chun Jimmie Ye, Katherine S. Pollard, Jay Shendure, Martin Kircher, Nadav Ahituv lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements Nature Protocols Nature Protocols Nature Protocols 2020/07/08 公開
Fumitaka Inoue, Anat Kreimer, Tal Ashuach, Nadav Ahituv, Nir Yosef Fumitaka Inoue, Anat Kreimer, Tal Ashuach, Nadav Ahituv, Nir Yosef Fumitaka Inoue, Anat Kreimer, Tal Ashuach, Nadav Ahituv, Nir Yosef Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction Cell Stem Cell, 25, 5, 713-727.e10 Cell Stem Cell, 25, 5, 713-727.e10 Cell Stem Cell, 25, 5, 713-727.e10 2019/11/07 公開
Martin Kircher, Chenling Xiong, Beth Martin, Max Schubach, Fumitaka Inoue, Robert J.A. Bell, Joseph F. Costello, Jay Shendure, Nadav Ahituv Martin Kircher, Chenling Xiong, Beth Martin, Max Schubach, Fumitaka Inoue, Robert J.A. Bell, Joseph F. Costello, Jay Shendure, Nadav Ahituv Martin Kircher, Chenling Xiong, Beth Martin, Max Schubach, Fumitaka Inoue, Robert J.A. Bell, Joseph F. Costello, Jay Shendure, Nadav Ahituv Saturation mutagenesis of twenty disease-associated regulatory elements at single base-pair resolution Saturation mutagenesis of twenty disease-associated regulatory elements at single base-pair resolution Saturation mutagenesis of twenty disease-associated regulatory elements at single base-pair resolution Nature Communications, 10, 1 Nature Communications, 10, 1 Nature Communications, 10, 1 2019/08/08 公開
Dustin Shigaki, Orit Adato, Aashish N. Adhikari, Shengcheng Dong, Alex Hawkins-Hooker, Fumitaka Inoue, Tamar Juven-Gershon, Henry Kenlay, Beth Martin, Ayoti Patra, Dmitry D. Penzar, Max Schubach, Chenling Xiong, Zhongxia Yan, Alan P. Boyle, Anat Kreimer, Ivan V. Kulakovskiy, John Reid, Ron Unger, Nir Yosef, Jay Shendure, Nadav Ahituv, Martin Kircher, Michael A. Beer Dustin Shigaki, Orit Adato, Aashish N. Adhikari, Shengcheng Dong, Alex Hawkins-Hooker, Fumitaka Inoue, Tamar Juven-Gershon, Henry Kenlay, Beth Martin, Ayoti Patra, Dmitry D. Penzar, Max Schubach, Chenling Xiong, Zhongxia Yan, Alan P. Boyle, Anat Kreimer, Ivan V. Kulakovskiy, John Reid, Ron Unger, Nir Yosef, Jay Shendure, Nadav Ahituv, Martin Kircher, Michael A. Beer Dustin Shigaki, Orit Adato, Aashish N. Adhikari, Shengcheng Dong, Alex Hawkins-Hooker, Fumitaka Inoue, Tamar Juven-Gershon, Henry Kenlay, Beth Martin, Ayoti Patra, Dmitry D. Penzar, Max Schubach, Chenling Xiong, Zhongxia Yan, Alan P. Boyle, Anat Kreimer, Ivan V. Kulakovskiy, John Reid, Ron Unger, Nir Yosef, Jay Shendure, Nadav Ahituv, Martin Kircher, Michael A. Beer Integration of multiple epigenomic marks improves prediction of variant impact in saturation mutagenesis reporter assay Integration of multiple epigenomic marks improves prediction of variant impact in saturation mutagenesis reporter assay Integration of multiple epigenomic marks improves prediction of variant impact in saturation mutagenesis reporter assay Human Mutation, 40, 9, 1280-1291 Human Mutation, 40, 9, 1280-1291 Human Mutation, 40, 9, 1280-1291 2019/05/20 公開
Fumitaka Inoue, Walter L. Eckalbar, Yi Wang, Karl K. Murphy, Navneet Matharu, Christian Vaisse, Nadav Ahituv Fumitaka Inoue, Walter L. Eckalbar, Yi Wang, Karl K. Murphy, Navneet Matharu, Christian Vaisse, Nadav Ahituv Fumitaka Inoue, Walter L. Eckalbar, Yi Wang, Karl K. Murphy, Navneet Matharu, Christian Vaisse, Nadav Ahituv Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation Nature Metabolism, 1, 4, 475-484 Nature Metabolism, 1, 4, 475-484 Nature Metabolism, 1, 4, 475-484 2019/04/08 公開
Fumitaka Inoue, Martin Kircher, Beth Martin, Gregory M. Cooper, Daniela M. Witten, Michael T. McManus, Nadav Ahituv, Jay Shendure Fumitaka Inoue, Martin Kircher, Beth Martin, Gregory M. Cooper, Daniela M. Witten, Michael T. McManus, Nadav Ahituv, Jay Shendure Fumitaka Inoue, Martin Kircher, Beth Martin, Gregory M. Cooper, Daniela M. Witten, Michael T. McManus, Nadav Ahituv, Jay Shendure Corrigendum: A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity Corrigendum: A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity Corrigendum: A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity Genome research, 28, 5 Genome research, 28, 5 Genome research, 28, 5 2018/05 公開
Fumitaka Inoue, Martin Kircher, Beth Martin, Gregory M. Cooper, Daniela M. Witten, Michael T. McManus, Nadav Ahituv, Jay Shendure Fumitaka Inoue, Martin Kircher, Beth Martin, Gregory M. Cooper, Daniela M. Witten, Michael T. McManus, Nadav Ahituv, Jay Shendure Fumitaka Inoue, Martin Kircher, Beth Martin, Gregory M. Cooper, Daniela M. Witten, Michael T. McManus, Nadav Ahituv, Jay Shendure A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity Genome Research, 27, 1, 38-52 Genome Research, 27, 1, 38-52 Genome Research, 27, 1, 38-52 2017/01 公開
Fumitaka Inoue, Nadav Ahituv Fumitaka Inoue, Nadav Ahituv Fumitaka Inoue, Nadav Ahituv Decoding enhancers using massively parallel reporter assays Decoding enhancers using massively parallel reporter assays Decoding enhancers using massively parallel reporter assays Genomics, 106, 3, 159-164 Genomics, 106, 3, 159-164 Genomics, 106, 3, 159-164 2015/09 公開
Robin P. Smith, Leila Taher, Rupali P. Patwardhan, Mee J. Kim, Fumitaka Inoue, Jay Shendure, Ivan Ovcharenko, Nadav Ahituv Robin P. Smith, Leila Taher, Rupali P. Patwardhan, Mee J. Kim, Fumitaka Inoue, Jay Shendure, Ivan Ovcharenko, Nadav Ahituv Robin P. Smith, Leila Taher, Rupali P. Patwardhan, Mee J. Kim, Fumitaka Inoue, Jay Shendure, Ivan Ovcharenko, Nadav Ahituv Massively parallel decoding of mammalian regulatory sequences supports a flexible organizational model Massively parallel decoding of mammalian regulatory sequences supports a flexible organizational model Massively parallel decoding of mammalian regulatory sequences supports a flexible organizational model Nature Genetics, 45, 9, 1021-1028 Nature Genetics, 45, 9, 1021-1028 Nature Genetics, 45, 9, 1021-1028 2013/07/28 公開
Fumitaka Inoue, Daisuke Kurokawa, Maiko Takahashi, Shinichi Aizawa Fumitaka Inoue, Daisuke Kurokawa, Maiko Takahashi, Shinichi Aizawa Fumitaka Inoue, Daisuke Kurokawa, Maiko Takahashi, Shinichi Aizawa Gbx2 Directly Restricts Otx2 Expression to Forebrain and Midbrain, Competing with Class III POU Factors Gbx2 Directly Restricts Otx2 Expression to Forebrain and Midbrain, Competing with Class III POU Factors Gbx2 Directly Restricts Otx2 Expression to Forebrain and Midbrain, Competing with Class III POU Factors Molecular and Cellular Biology, 32, 13, 2618-2627 Molecular and Cellular Biology, 32, 13, 2618-2627 Molecular and Cellular Biology, 32, 13, 2618-2627 2012/07 公開
Yoko Suda, Kenji Kokura, Jun Kimura, Eriko Kajikawa, Fumitaka Inoue, Shinichi Aizawa Yoko Suda, Kenji Kokura, Jun Kimura, Eriko Kajikawa, Fumitaka Inoue, Shinichi Aizawa Yoko Suda, Kenji Kokura, Jun Kimura, Eriko Kajikawa, Fumitaka Inoue, Shinichi Aizawa The same enhancer regulates the earliest Emx2 expression in caudal forebrain primordium, subsequent expression in dorsal telencephalon and later expression in the cortical ventricular zone The same enhancer regulates the earliest Emx2 expression in caudal forebrain primordium, subsequent expression in dorsal telencephalon and later expression in the cortical ventricular zone The same enhancer regulates the earliest Emx2 expression in caudal forebrain primordium, subsequent expression in dorsal telencephalon and later expression in the cortical ventricular zone Development, 137, 17, 2939-2949 Development, 137, 17, 2939-2949 Development, 137, 17, 2939-2949 2010/09 公開
Daisuke Kurokawa, Tomomi Ohmura, Hajime Ogino, Masaki Takeuchi, Ai Inoue, Fumitaka Inoue, Yoko Suda, Shinichi Aizawa Daisuke Kurokawa, Tomomi Ohmura, Hajime Ogino, Masaki Takeuchi, Ai Inoue, Fumitaka Inoue, Yoko Suda, Shinichi Aizawa Daisuke Kurokawa, Tomomi Ohmura, Hajime Ogino, Masaki Takeuchi, Ai Inoue, Fumitaka Inoue, Yoko Suda, Shinichi Aizawa Evolutionary origin of the Otx2 enhancer for its expression in visceral endoderm Evolutionary origin of the Otx2 enhancer for its expression in visceral endoderm Evolutionary origin of the Otx2 enhancer for its expression in visceral endoderm Developmental Biology, 342, 1, 110-120 Developmental Biology, 342, 1, 110-120 Developmental Biology, 342, 1, 110-120 2010/06 公開
Mst Shahnaj Parvin, Noriko Okuyama, Fumitaka Inoue, Md Ekramul Islam, Atsushi Kawakami, Hiroyuki Takeda, Kyo Yamasu Mst Shahnaj Parvin, Noriko Okuyama, Fumitaka Inoue, Md Ekramul Islam, Atsushi Kawakami, Hiroyuki Takeda, Kyo Yamasu Mst Shahnaj Parvin, Noriko Okuyama, Fumitaka Inoue, Md Ekramul Islam, Atsushi Kawakami, Hiroyuki Takeda, Kyo Yamasu Autoregulatory loop and retinoic acid repression regulate pou2/pou5f1 gene expression in the zebrafish embryonic brain Autoregulatory loop and retinoic acid repression regulate pou2/pou5f1 gene expression in the zebrafish embryonic brain Autoregulatory loop and retinoic acid repression regulate pou2/pou5f1 gene expression in the zebrafish embryonic brain Developmental Dynamics, 237, 5, 1373-1388 Developmental Dynamics, 237, 5, 1373-1388 Developmental Dynamics, 237, 5, 1373-1388 2008/05 公開
Fumitaka Inoue, Mst Shahnaj Parvin, Kyo Yamasu Fumitaka Inoue, Mst Shahnaj Parvin, Kyo Yamasu Fumitaka Inoue, Mst Shahnaj Parvin, Kyo Yamasu Transcription of fgf8 is regulated by activating and repressive cis-elements at the midbrain-hindbrain boundary in zebrafish embryos Transcription of fgf8 is regulated by activating and repressive cis-elements at the midbrain-hindbrain boundary in zebrafish embryos Transcription of fgf8 is regulated by activating and repressive cis-elements at the midbrain-hindbrain boundary in zebrafish embryos Developmental Biology, 316, 2, 471-486 Developmental Biology, 316, 2, 471-486 Developmental Biology, 316, 2, 471-486 2008/04 公開
Md Ekramul Islam, Hiroshi Kikuta, Fumitaka Inoue, Maiko Kanai, Atsushi Kawakami, Mst Shahnaj Parvin, Hiroyuki Takeda, Kyo Yamasu Md Ekramul Islam, Hiroshi Kikuta, Fumitaka Inoue, Maiko Kanai, Atsushi Kawakami, Mst Shahnaj Parvin, Hiroyuki Takeda, Kyo Yamasu Md Ekramul Islam, Hiroshi Kikuta, Fumitaka Inoue, Maiko Kanai, Atsushi Kawakami, Mst Shahnaj Parvin, Hiroyuki Takeda, Kyo Yamasu Three enhancer regions regulate gbx2 gene expression in the isthmic region during zebrafish development Three enhancer regions regulate gbx2 gene expression in the isthmic region during zebrafish development Three enhancer regions regulate gbx2 gene expression in the isthmic region during zebrafish development Mechanisms of Development, 123, 12, 907-924 Mechanisms of Development, 123, 12, 907-924 Mechanisms of Development, 123, 12, 907-924 2006/12 公開
Fumitaka Inoue, Saori Nagayoshi, Satoshi Ota, Md Ekramul Islam, Noriko Tonou-Fujimori, Yuko Odaira, Koichi Kawakami, Kyo Yamasu Fumitaka Inoue, Saori Nagayoshi, Satoshi Ota, Md Ekramul Islam, Noriko Tonou-Fujimori, Yuko Odaira, Koichi Kawakami, Kyo Yamasu Fumitaka Inoue, Saori Nagayoshi, Satoshi Ota, Md Ekramul Islam, Noriko Tonou-Fujimori, Yuko Odaira, Koichi Kawakami, Kyo Yamasu Genomic organization, alternative splicing, and multiple regulatory regions of the zebrafish fgf8 gene Genomic organization, alternative splicing, and multiple regulatory regions of the zebrafish fgf8 gene Genomic organization, alternative splicing, and multiple regulatory regions of the zebrafish fgf8 gene Development Growth and Differentiation, 48, 7, 447-462 Development Growth and Differentiation, 48, 7, 447-462 Development Growth and Differentiation, 48, 7, 447-462 2006/09 公開

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タイトル言語:
Misc
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
井上詞貴 井上詞貴 Fumitaka Inoue 大規模並列レポーターアッセイによる神経誘導メカニズムの解読 大規模並列レポーターアッセイによる神経誘導メカニズムの解読 Decoding neural induction using massively parallel reporter assays 実験医学, 38, 4 実験医学, 38, 4 Jikken Igaku, 38, 4 2020/03 日本語 記事・総説・解説・論説等(学術雑誌) 公開
井上詞貴 井上詞貴 Fumitaka Inoue 視床下部におけるレプチン応答ゲノム・エピゲノム解析 視床下部におけるレプチン応答ゲノム・エピゲノム解析 Genomic and epigenomic mapping of leptin-responsive neurons in the hypothalamus 実験医学, 37, 14 実験医学, 37, 14 Jikken Igaku, 37, 14 2019/09 日本語 記事・総説・解説・論説等(学術雑誌) 公開
タイトル言語:
講演・口頭発表等
タイトル タイトル(日本語) タイトル(英語) 会議名 会議名(日本語) 会議名(英語) 主催者 主催者(日本語) 主催者(英語) 発表年月日 記述言語 会議種別 公開
大規模並列レポーターアッセイが紐解く細胞分化、進化、疾患[招待あり] 大規模並列レポーターアッセイが紐解く細胞分化、進化、疾患 [招待あり] 第10回 都医学研シンポジウム ゲノム機能解析の進展とその医科学への応用 第10回 都医学研シンポジウム ゲノム機能解析の進展とその医科学への応用 2020/11/27 日本語 公開講演、セミナー、チュートリアル、講習、講義 公開
Functional Dissection of Neural Enhancers Using Massively Parallel Reporter Assays[招待あり] Functional Dissection of Neural Enhancers Using Massively Parallel Reporter Assays [招待あり] Functional Dissection of Neural Enhancers Using Massively Parallel Reporter Assays [招待あり] The 7th Annual Molecular Psychiatry Meeting The 7th Annual Molecular Psychiatry Meeting The 7th Annual Molecular Psychiatry Meeting 2019/10/17 英語 シンポジウム・ワークショップパネル(指名) 公開
Decoding the mechanism of neural differentiation by massively parallel reporter assays Decoding the mechanism of neural differentiation by massively parallel reporter assays Decoding the mechanism of neural differentiation by massively parallel reporter assays Consortium of Biological Sciences 2017 (ConBio2017) Consortium of Biological Sciences 2017 (ConBio2017) Consortium of Biological Sciences 2017 (ConBio2017) 2017/12 英語 口頭発表(一般) 公開
Gbx2 directly restricts Otx2 expression to forebrain and midbrain, competing with Class III POU factors Gbx2 directly restricts Otx2 expression to forebrain and midbrain, competing with Class III POU factors Gbx2 directly restricts Otx2 expression to forebrain and midbrain, competing with Class III POU factors 第34回日本分子生物学会年会 第34回日本分子生物学会年会 2011/12 英語 口頭発表(一般) 公開
Molecular evolution of the vertebrate Fgf8 subfamily of fibroblast growth factors and their enhancers for the midbrain-hindbrain boundary Molecular evolution of the vertebrate Fgf8 subfamily of fibroblast growth factors and their enhancers for the midbrain-hindbrain boundary Molecular evolution of the vertebrate Fgf8 subfamily of fibroblast growth factors and their enhancers for the midbrain-hindbrain boundary 第30回日本分子生物学会年会 第30回日本分子生物学会年会 2007/12 日本語 口頭発表(一般) 公開
ゼブラフィッシュ胚の中脳後脳境界におけるfgf8遺伝子の転写制御 ゼブラフィッシュ胚の中脳後脳境界におけるfgf8遺伝子の転写制御 ゼブラフィッシュ胚の中脳後脳境界におけるfgf8遺伝子の転写制御 第12回小型魚類研究会 第12回小型魚類研究会 2006/09 日本語 公開
Regulatory mechanism of the transcription of fgf8 during zebrafish brain formation Regulatory mechanism of the transcription of fgf8 during zebrafish brain formation Regulatory mechanism of the transcription of fgf8 during zebrafish brain formation 10th Japanese Medaka and Zebrafish Meeting 10th Japanese Medaka and Zebrafish Meeting 10th Japanese Medaka and Zebrafish Meeting 2004/11 口頭発表(一般) 公開
タイトル言語:
学術賞等
賞の名称(日本語) 賞の名称(英語) 授与組織名(日本語) 授与組織名(英語) 年月
ポスター賞 Best Poster Award ENCODE Consortium Meeting 2018/02/07
外部資金:競争的資金 (科学研究費補助金)
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
基盤研究(C) 代表 大規模並列レポーターアッセイ法による転移因子進化メカニズムの解明 2021/04/01〜2024/03/31
基盤研究(B) 分担 Evaluating the role of cis-regulatory tandem DNA repeats in human disease and evolution 2021/04/01〜2024/03/31
外部資金:競争的資金 (科学研究費補助金以外)
制度名 代表者名 研究課題(日本語) 研究課題(英語) 期間
上原記念生命科学財団 井上詞貴 遺伝子制御エレメントの大規模並列機能解析 Massively parallel functional analysis of gene regulatory elements 2013/01/01〜2013/12/31