玉利 勇樹

Last Update: 2021/06/21 15:35:14

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Name(Kanji/Kana/Abecedarium Latinum)
玉利 勇樹/タマリ ユウキ/Tamari, Yuki
Primary Affiliation(Org1/Job title)
Institute for Integrated Radiation and Nuclear Science (KURNS)/Program-Specific Assistant Professor
Affiliated programs (koza)
Org1 Job title
Graduate School of Medicine Assistant Professor
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(医科学) 京都大学
博士(医学) 大分大学
researchmap URL
https://researchmap.jp/7000018119
Research Topics
(Japanese)
膵臓がん細胞株Panc-1における IL-6による放射線抵抗性獲得機構の解明
(English)
Elucidation of the radioresistant acquisition mechanism with IL-6 in pancreatic cancer cells.
Overview of the research
(Japanese)
放射線治療はがん治療の手段として有効であるが、がんの放射線抵抗性獲得が一つの大きな壁となっている。がん細胞の放射線抵抗性獲得に関わる要因の一つと考えられるのが、サイトカインの一種であるインターロイキン6(IL-6)である。本研究ではIL-6による活性酸素種抑制を介したがんの放射線抵抗性獲得のメカニズムを明らかにし、実際の生体内でのがんに対するIL-6の影響を明確にすることを目的とする。細胞株は膵臓がん由来細胞株を使用し、IL-6がミトコンドリアを介した活性酸素種産生を抑制するメカニズムを調査する。次に鶏卵を使用し腫瘍モデルを作成する。この腫瘍モデル内でIL-6ががん細胞にどのように影響するのかを調べていく。本研究により放射線抵抗性獲得のメカニズムが解明されることで放射線治療の治療成績の向上が期待される。
(English)
The radiation therapy is effective as means of the cancer treatment, but the radioresistant acquisition of cancer becomes one big wall. It is interleukin-6 (IL-6) that it is a kind of cytokine that it is thought that it is one of the factors about radioresistant acquisition of the cancer cell. In this study, we will clarify mechanism of the radioresistant acquisition of cancer through the reactive oxygen species restraint with IL-6 and influence of IL-6 for in vivo tumor cells. In this study, cell strain derived from pancreatic cancer is used and mechanism that IL-6 controls the reactive oxygen species production through mitochondria is investigated. Next, tumor models are made with a chicken egg. We investigate how IL-6 influences a cancer cell in this tumor model. The result that mechanism of the radioresistant acquisition is elucidated by this study, the improvement of the treatment result of the radiation therapy is expected.
Fields of research (key words)
Key words(Japanese) Key words(English)
インターロイキン6 Interleukin-6
放射線抵抗性 radioresistance
腫瘍 tumor
ミトコンドリア mitochondria
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Takuya Fujimoto, Minoru Suzuki, Shigeyuki Kuratsu, Ikuo Fujita, Masayuki Morishita, Tamotsu Sudo, Toshiko Sakuma, Yuta Nakamatsu, Yoshinori Sakurai, Takushi Takata, Yuki Tamari, Hiroki Tanaka, Shin-Ichiro Masunaga, Yuko Kinashi, Natsuko Kondo, Shunsuke Sakakibara, Hiroshi Igaki, Tooru Andoh, Setsu Sakamoto, Teruya Kawamoto, Tadashi Watabe, Hitomi Hara, Naomasa Fukase, Yohei Kawakami, Tomoyuki Matsumoto, Toshihiro Akisue, Koji Ono, Hideki Ichikawa, Ryosuke Kuroda, Takanori Hirose Takuya Fujimoto, Minoru Suzuki, Shigeyuki Kuratsu, Ikuo Fujita, Masayuki Morishita, Tamotsu Sudo, Toshiko Sakuma, Yuta Nakamatsu, Yoshinori Sakurai, Takushi Takata, Yuki Tamari, Hiroki Tanaka, Shin-Ichiro Masunaga, Yuko Kinashi, Natsuko Kondo, Shunsuke Sakakibara, Hiroshi Igaki, Tooru Andoh, Setsu Sakamoto, Teruya Kawamoto, Tadashi Watabe, Hitomi Hara, Naomasa Fukase, Yohei Kawakami, Tomoyuki Matsumoto, Toshihiro Akisue, Koji Ono, Hideki Ichikawa, Ryosuke Kuroda, Takanori Hirose Takuya Fujimoto, Minoru Suzuki, Shigeyuki Kuratsu, Ikuo Fujita, Masayuki Morishita, Tamotsu Sudo, Toshiko Sakuma, Yuta Nakamatsu, Yoshinori Sakurai, Takushi Takata, Yuki Tamari, Hiroki Tanaka, Shin-Ichiro Masunaga, Yuko Kinashi, Natsuko Kondo, Shunsuke Sakakibara, Hiroshi Igaki, Tooru Andoh, Setsu Sakamoto, Teruya Kawamoto, Tadashi Watabe, Hitomi Hara, Naomasa Fukase, Yohei Kawakami, Tomoyuki Matsumoto, Toshihiro Akisue, Koji Ono, Hideki Ichikawa, Ryosuke Kuroda, Takanori Hirose BNCT for primary synovial sarcoma. BNCT for primary synovial sarcoma. BNCT for primary synovial sarcoma. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 169, 109407-109407 Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 169, 109407-109407 Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 169, 109407-109407 2021/03 English Research paper(scientific journal) Disclose to all
Takuya Fujimoto, Minoru Suzuki, Tamotsu Sudo, Ikuo Fujita, Toshiko Sakuma, Yoshinori Sakurai, Takanori Hirose, Masayuki Morishita, Takushi Takata, Yuki Tamari, Hiroki Tanaka, Tooru Andoh, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Yohei Kawakami, Rika Shigemoto, Tomoyuki Matsumoto, Hideki Ichikawa, Koji Ono, Ryosuke Kuroda, Toshihiro Akisue Takuya Fujimoto, Minoru Suzuki, Tamotsu Sudo, Ikuo Fujita, Toshiko Sakuma, Yoshinori Sakurai, Takanori Hirose, Masayuki Morishita, Takushi Takata, Yuki Tamari, Hiroki Tanaka, Tooru Andoh, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Yohei Kawakami, Rika Shigemoto, Tomoyuki Matsumoto, Hideki Ichikawa, Koji Ono, Ryosuke Kuroda, Toshihiro Akisue Takuya Fujimoto, Minoru Suzuki, Tamotsu Sudo, Ikuo Fujita, Toshiko Sakuma, Yoshinori Sakurai, Takanori Hirose, Masayuki Morishita, Takushi Takata, Yuki Tamari, Hiroki Tanaka, Tooru Andoh, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Yohei Kawakami, Rika Shigemoto, Tomoyuki Matsumoto, Hideki Ichikawa, Koji Ono, Ryosuke Kuroda, Toshihiro Akisue Boron neutron capture therapy for clear cell sarcoma. Boron neutron capture therapy for clear cell sarcoma. Boron neutron capture therapy for clear cell sarcoma. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 166, 109324-109324 Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 166, 109324-109324 Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 166, 109324-109324 2020/12 English Research paper(scientific journal) Disclose to all
Koji Ono, Hiroki Tanaka, Yuki Tamari, Tsubasa Watanabe, Minoru Suzuki, Shin-Ichiro Masunaga Koji Ono, Hiroki Tanaka, Yuki Tamari, Tsubasa Watanabe, Minoru Suzuki, Shin-Ichiro Masunaga Koji Ono, Hiroki Tanaka, Yuki Tamari, Tsubasa Watanabe, Minoru Suzuki, Shin-Ichiro Masunaga Proposal for determining absolute biological effectiveness of boron neutron capture therapy-the effect of 10B(n,α)7Li dose can be predicted from the nucleocytoplasmic ratio or the cell size. Proposal for determining absolute biological effectiveness of boron neutron capture therapy-the effect of 10B(n,α)7Li dose can be predicted from the nucleocytoplasmic ratio or the cell size. Proposal for determining absolute biological effectiveness of boron neutron capture therapy-the effect of 10B(n,α)7Li dose can be predicted from the nucleocytoplasmic ratio or the cell size. Journal of radiation research, 60, 1, 29-36 Journal of radiation research, 60, 1, 29-36 Journal of radiation research, 60, 1, 29-36 2019/01/01 Refereed English Research paper(scientific journal) Disclose to all
Yuki Tamari, Genro Kashino, Hiromu Mori 玉利 勇樹 Yuki Tamari, Genro Kashino, Hiromu Mori Acquisition of radioresistance by IL-6 treatment is caused by suppression of oxidative stress derived from mitochondria after γ-irradiation. IL-6による放射線抵抗性獲得はγ線照射後のミトコンドリア由来酸化ストレスを抑制することにより引き起こされる Acquisition of radioresistance by IL-6 treatment is caused by suppression of oxidative stress derived from mitochondria after γ-irradiation. Journal of radiation research, 58, 4, 412-420 Journal of Radiation Research, 58, 4, 412-420 Journal of radiation research, 58, 4, 412-420 2017/07/01 Refereed English Research paper(scientific journal) Disclose to all
Genro Kashino, Y. Tamari, J. Kumagai, K. Tano, M. Watanabe Genro Kashino, Y. Tamari, J. Kumagai, K. Tano, M. Watanabe Genro Kashino, Y. Tamari, J. Kumagai, K. Tano, M. Watanabe Suppressive effect of ascorbic acid on the mutagenesis induced by the bystander effect through mitochondrial function Suppressive effect of ascorbic acid on the mutagenesis induced by the bystander effect through mitochondrial function Suppressive effect of ascorbic acid on the mutagenesis induced by the bystander effect through mitochondrial function Free Radical Research, 47, 6-7, 474-479 Free Radical Research, 47, 6-7, 474-479 Free Radical Research, 47, 6-7, 474-479 2013/07 Refereed English Research paper(scientific journal) Disclose to all
Yuki Tamari, Hisakatsu Nawata, Eri Inoue, Akari Yoshimura, Hanako Yoshii, Genro Kashino, Masayuki Seki, Takemi Enomoto, Masami Watanabe, Keizo Tano Yuki Tamari, Hisakatsu Nawata, Eri Inoue, Akari Yoshimura, Hanako Yoshii, Genro Kashino, Masayuki Seki, Takemi Enomoto, Masami Watanabe, Keizo Tano Yuki Tamari, Hisakatsu Nawata, Eri Inoue, Akari Yoshimura, Hanako Yoshii, Genro Kashino, Masayuki Seki, Takemi Enomoto, Masami Watanabe, Keizo Tano Protective roles of ascorbic acid in oxidative stress induced by depletion of superoxide dismutase in vertebrate cells. Protective roles of ascorbic acid in oxidative stress induced by depletion of superoxide dismutase in vertebrate cells. Protective roles of ascorbic acid in oxidative stress induced by depletion of superoxide dismutase in vertebrate cells. Free radical research, 47, 1, 1-7 Free radical research, 47, 1, 1-7 Free radical research, 47, 1, 1-7 2013/01 Refereed English Research paper(scientific journal) Disclose to all
Title language:
Misc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
菓子野元郎, 玉利勇樹, 岡田卓也, 西浦英樹, 田野恵三, 渡邉正己 菓子野元郎, 玉利勇樹, 岡田卓也, 西浦英樹, 田野恵三, 渡邉正己 ビタミンCによるバイスタンダー反応抑制機構 ビタミンCによるバイスタンダー反応抑制機構 日本放射線影響学会第54回大会,放射線に及ぼすビタミンCの効果に関するワークショップ 日本放射線影響学会第54回大会,放射線に及ぼすビタミンCの効果に関するワークショップ 2011/11 Refereed Japanese Research paper, summary (national conference and other science council) Disclose to all
Title language:
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
若手研究 Representative 膵臓がん細胞株Panc-1における IL-6による放射線抵抗性獲得機構の解明 (2019年度分) 2019/04/01-2020/03/31