橋口 隆生

Last Update: 2021/06/16 16:53:30

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Name(Kanji/Kana/Abecedarium Latinum)
橋口 隆生/ハシグチ タカオ/Hashiguchi, Takao
Primary Affiliation(Org1/Job title)
Institute for Frontier Life and Medical Sciences/Professor
Affiliated programs (koza)
Org1 Job title
Graduate Schools Pharmaceutical Sciences Professor
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(医科学) 九州大学
博士(医学) 九州大学
Personal Profile
(Japanese)
感染症は今なお世界中の子どもたちの脅威となっています。この問題を解決するため、私たちは小児関連のウイルス感染症の研究を行っています。特に、ウイルスの細胞侵入機構および化合物・ペプチド・糖鎖・抗体による侵入阻害機構の解明に注力し、ウイルス学的手法と構造生物学的手法を組み合わせたアプローチで研究を進めています。主要研究項目としては、ウイルスの病原性の解明とウイルス疾患に対する予防・治療法開発の2つが大きな柱となっています。
(English)
Infectious diseases still have been a fatal threat to children, worldwide. To solve the problem, we have been studying on pediatric virology. In particular, we focus on the mechanisms of viral entry into cells and the inhibition of entry by compounds, peptides, glycans, and antibodies, using a combination of virological and structural biological approaches. Our major goals are the elucidation of viral pathogenesis and the development of preventive and therapeutic methods for viral diseases.
ORCID ID
https://orcid.org/0000-0001-7578-7571
researchmap URL
https://researchmap.jp/virology_structure
Research Topics
(Japanese)
1. ウイルスの病原性の解明(小児関連のウイルス感染症を中心に) 2. ウイルス性疾患に対する予防・治療法開発
(English)
1. elucidation of viral pathogenesis 2. development of prevention and therapeutics for viral diseases
Overview of the research
(Japanese)
感染症は今なお世界中の子どもたちの脅威となっています。この問題を解決するため、私たちは小児関連のウイルス感染症の研究を行っています。特に、ウイルスの細胞侵入機構および化合物・ペプチド・糖鎖・抗体による侵入阻害機構の解明に注力し、ウイルス学的手法と構造生物学的手法を組み合わせたアプローチで研究を進めています。主要研究項目としては、ウイルスの病原性の解明とウイルス疾患に対する予防・治療法開発の2つが大きな柱となっています。
(English)
Infectious diseases still have been a fatal threat to children, worldwide. To solve the problem, we have been studying on pediatric virology. In particular, we focus on the mechanisms of viral entry into cells and the inhibition of entry by compounds, peptides, glycans, and antibodies, using a combination of virological and structural biological approaches. Our major goals are the elucidation of viral pathogenesis and the development of preventive and therapeutic methods for viral diseases.
Fields of research (key words)
Key words(Japanese) Key words(English)
ウイルス学、病理病態学、感染・免疫学およびその関連分野、構造生物学、創薬化学
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Ayako Ueo, Marie Kubota, Yuta Shirogane, Shinji Ohno, Takao Hashiguchi, Yusuke Yanagi Ayako Ueo, Marie Kubota, Yuta Shirogane, Shinji Ohno, Takao Hashiguchi, Yusuke Yanagi Ayako Ueo, Marie Kubota, Yuta Shirogane, Shinji Ohno, Takao Hashiguchi, Yusuke Yanagi Lysosome-Associated Membrane Proteins Support the Furin-Mediated Processing of the Mumps Virus Fusion Protein. Lysosome-Associated Membrane Proteins Support the Furin-Mediated Processing of the Mumps Virus Fusion Protein. Lysosome-Associated Membrane Proteins Support the Furin-Mediated Processing of the Mumps Virus Fusion Protein. Journal of virology, 94, 12 Journal of virology, 94, 12 Journal of virology, 94, 12 2020/06/01 Refereed English Research paper(scientific journal) Disclose to all
Rosa Ester Forgione, Cristina Di Carluccio, Marie Kubota, Yoshiyuki Manabe, Koichi Fukase, Antonio Molinaro, Takao Hashiguchi, Roberta Marchetti, Alba Silipo Rosa Ester Forgione, Cristina Di Carluccio, Marie Kubota, Yoshiyuki Manabe, Koichi Fukase, Antonio Molinaro, Takao Hashiguchi, Roberta Marchetti, Alba Silipo Rosa Ester Forgione, Cristina Di Carluccio, Marie Kubota, Yoshiyuki Manabe, Koichi Fukase, Antonio Molinaro, Takao Hashiguchi, Roberta Marchetti, Alba Silipo Structural basis for Glycan-receptor binding by mumps virus hemagglutinin-neuraminidase. Structural basis for Glycan-receptor binding by mumps virus hemagglutinin-neuraminidase. Structural basis for Glycan-receptor binding by mumps virus hemagglutinin-neuraminidase. Scientific reports, 10, 1, 1589-1589 Scientific reports, 10, 1, 1589-1589 Scientific reports, 10, 1, 1589-1589 2020/01/31 Refereed English Research paper(scientific journal) Disclose to all
Yuta Shirogane, Takao Hashiguchi, Yusuke Yanagi Yuta Shirogane, Takao Hashiguchi, Yusuke Yanagi Yuta Shirogane, Takao Hashiguchi, Yusuke Yanagi Weak cis and trans Interactions of the Hemagglutinin with Receptors Trigger Fusion Proteins of Neuropathogenic Measles Virus Isolates. Weak cis and trans Interactions of the Hemagglutinin with Receptors Trigger Fusion Proteins of Neuropathogenic Measles Virus Isolates. Weak cis and trans Interactions of the Hemagglutinin with Receptors Trigger Fusion Proteins of Neuropathogenic Measles Virus Isolates. Journal of virology, 94, 2 Journal of virology, 94, 2 Journal of virology, 94, 2 2020/01/06 Refereed English Research paper(scientific journal) Disclose to all
Marie Kubota, Iori Okabe, Shin-Ichi Nakakita, Ayako Ueo, Yuta Shirogane, Yusuke Yanagi, Takao Hashiguchi Marie Kubota, Iori Okabe, Shin-Ichi Nakakita, Ayako Ueo, Yuta Shirogane, Yusuke Yanagi, Takao Hashiguchi Marie Kubota, Iori Okabe, Shin-Ichi Nakakita, Ayako Ueo, Yuta Shirogane, Yusuke Yanagi, Takao Hashiguchi Disruption of the Dimer-Dimer Interaction of the Mumps Virus Attachment Protein Head Domain, Aided by an Anion Located at the Interface, Compromises Membrane Fusion Triggering. Disruption of the Dimer-Dimer Interaction of the Mumps Virus Attachment Protein Head Domain, Aided by an Anion Located at the Interface, Compromises Membrane Fusion Triggering. Disruption of the Dimer-Dimer Interaction of the Mumps Virus Attachment Protein Head Domain, Aided by an Anion Located at the Interface, Compromises Membrane Fusion Triggering. Journal of virology, 94, 2 Journal of virology, 94, 2 Journal of virology, 94, 2 2020/01/06 Refereed English Research paper(scientific journal) Disclose to all
Marie Kubota, Takao Hashiguchi Marie Kubota, Takao Hashiguchi Marie Kubota, Takao Hashiguchi Large-Scale Expression and Purification of Mumps Virus Hemagglutinin-Neuraminidase for Structural Analyses and Glycan-Binding Assays. Large-Scale Expression and Purification of Mumps Virus Hemagglutinin-Neuraminidase for Structural Analyses and Glycan-Binding Assays. Large-Scale Expression and Purification of Mumps Virus Hemagglutinin-Neuraminidase for Structural Analyses and Glycan-Binding Assays. Methods in molecular biology (Clifton, N.J.), 2132, 641-652 Methods in molecular biology (Clifton, N.J.), 2132, 641-652 Methods in molecular biology (Clifton, N.J.), 2132, 641-652 2020 Refereed English Research paper(scientific journal) Disclose to all
Takashi Tadokoro, Mst Lubna Jahan, Yuri Ito, Maino Tahara, Surui Chen, Atsutoshi Imai, Natsumi Sugimura, Koki Yoshida, Mizuki Saito, Toyoyuki Ose, Takao Hashiguchi, Makoto Takeda, Hideo Fukuhara, Katsumi Maenaka Takashi Tadokoro, Mst Lubna Jahan, Yuri Ito, Maino Tahara, Surui Chen, Atsutoshi Imai, Natsumi Sugimura, Koki Yoshida, Mizuki Saito, Toyoyuki Ose, Takao Hashiguchi, Makoto Takeda, Hideo Fukuhara, Katsumi Maenaka Takashi Tadokoro, Mst Lubna Jahan, Yuri Ito, Maino Tahara, Surui Chen, Atsutoshi Imai, Natsumi Sugimura, Koki Yoshida, Mizuki Saito, Toyoyuki Ose, Takao Hashiguchi, Makoto Takeda, Hideo Fukuhara, Katsumi Maenaka Biophysical characterization and single-chain Fv construction of a neutralizing antibody to measles virus. Biophysical characterization and single-chain Fv construction of a neutralizing antibody to measles virus. Biophysical characterization and single-chain Fv construction of a neutralizing antibody to measles virus. The FEBS journal, 287, 1, 145-159 The FEBS journal, 287, 1, 145-159 The FEBS journal, 287, 1, 145-159 2020/01 Refereed English Disclose to all
Hideo Fukuhara, Yuri Ito, Miyuki Sako, Mizuho Kajikawa, Koki Yoshida, Fumio Seki, Mwila Hilton Mwaba, Takao Hashiguchi, Masa-Aki Higashibata, Toyoyuki Ose, Kimiko Kuroki, Makoto Takeda, Katsumi Maenaka Hideo Fukuhara, Yuri Ito, Miyuki Sako, Mizuho Kajikawa, Koki Yoshida, Fumio Seki, Mwila Hilton Mwaba, Takao Hashiguchi, Masa-Aki Higashibata, Toyoyuki Ose, Kimiko Kuroki, Makoto Takeda, Katsumi Maenaka Hideo Fukuhara, Yuri Ito, Miyuki Sako, Mizuho Kajikawa, Koki Yoshida, Fumio Seki, Mwila Hilton Mwaba, Takao Hashiguchi, Masa-Aki Higashibata, Toyoyuki Ose, Kimiko Kuroki, Makoto Takeda, Katsumi Maenaka Specificity of Morbillivirus Hemagglutinins to Recognize SLAM of Different Species. Specificity of Morbillivirus Hemagglutinins to Recognize SLAM of Different Species. Specificity of Morbillivirus Hemagglutinins to Recognize SLAM of Different Species. Viruses, 11, 8 Viruses, 11, 8 Viruses, 11, 8 2019/08/19 Refereed English Disclose to all
Kubota M, Matsuoka R, Suzuki T, Yonekura K, Yanagi Y, Hashiguchi T Kubota M, Matsuoka R, Suzuki T, Yonekura K, Yanagi Y, Hashiguchi T Kubota M, Matsuoka R, Suzuki T, Yonekura K, Yanagi Y, Hashiguchi T Molecular mechanism of the flexible glycan-receptor recognition by mumps virus. Molecular mechanism of the flexible glycan-receptor recognition by mumps virus. Molecular mechanism of the flexible glycan-receptor recognition by mumps virus. <i><b>Journal of virology</b></i> <i><b>Journal of virology</b></i> <i><b>Journal of virology</b></i> 2019/05 Refereed Disclose to all
Shumpei Watanabe, Yuta Shirogane, Yuma Sato, Takao Hashiguchi, Yusuke Yanagi Shumpei Watanabe, Yuta Shirogane, Yuma Sato, Takao Hashiguchi, Yusuke Yanagi Shumpei Watanabe, Yuta Shirogane, Yuma Sato, Takao Hashiguchi, Yusuke Yanagi New Insights into Measles Virus Brain Infections. New Insights into Measles Virus Brain Infections. New Insights into Measles Virus Brain Infections. Trends in microbiology, 27, 2, 164-175 Trends in microbiology, 27, 2, 164-175 Trends in microbiology, 27, 2, 164-175 2019/02 Refereed English Disclose to all
Mathieu C, Ferren M, Jurgens E, Dumont C, Rybkina K, Harder O, Stelitano D, Madeddu S, Sanna G, Schwartz D, Biswas S, Hardie D, Hashiguchi T, Moscona A, Horvat B, Niewiesk S, Porotto M Mathieu C, Ferren M, Jurgens E, Dumont C, Rybkina K, Harder O, Stelitano D, Madeddu S, Sanna G, Schwartz D, Biswas S, Hardie D, Hashiguchi T, Moscona A, Horvat B, Niewiesk S, Porotto M Mathieu C, Ferren M, Jurgens E, Dumont C, Rybkina K, Harder O, Stelitano D, Madeddu S, Sanna G, Schwartz D, Biswas S, Hardie D, Hashiguchi T, Moscona A, Horvat B, Niewiesk S, Porotto M Measles virus bearing MIBE-derived fusion protein is pathogenic after infection via the respiratory route. Measles virus bearing MIBE-derived fusion protein is pathogenic after infection via the respiratory route. Measles virus bearing MIBE-derived fusion protein is pathogenic after infection via the respiratory route. <i><b>Journal of virology</b></i> <i><b>Journal of virology</b></i> <i><b>Journal of virology</b></i> 2019/02 Refereed Disclose to all
Angius F, Smuts H, Rybkina K, Stelitano D, Eley B, Wilmshurst J, Ferren M, Lalande A, Mathieu C, Moscona A, Horvat B, Hashiguchi T, Porotto M, Hardie D Angius F, Smuts H, Rybkina K, Stelitano D, Eley B, Wilmshurst J, Ferren M, Lalande A, Mathieu C, Moscona A, Horvat B, Hashiguchi T, Porotto M, Hardie D Angius F, Smuts H, Rybkina K, Stelitano D, Eley B, Wilmshurst J, Ferren M, Lalande A, Mathieu C, Moscona A, Horvat B, Hashiguchi T, Porotto M, Hardie D Analysis of a subacute sclerosing panencephalitis (SSPE) Genotype B3 virus from the 2009/10 South African measles epidemic shows hyperfusogenic F proteins contribute to measles virus infection in the brain. Analysis of a subacute sclerosing panencephalitis (SSPE) Genotype B3 virus from the 2009/10 South African measles epidemic shows hyperfusogenic F proteins contribute to measles virus infection in the brain. Analysis of a subacute sclerosing panencephalitis (SSPE) Genotype B3 virus from the 2009/10 South African measles epidemic shows hyperfusogenic F proteins contribute to measles virus infection in the brain. <i><b>Journal of virology</b></i> <i><b>Journal of virology</b></i> <i><b>Journal of virology</b></i> 2018/11 Refereed Disclose to all
Takao Hashiguchi, Yoshinari Fukuda, Rei Matsuoka, Daisuke Kuroda, Marie Kubota, Yuta Shirogane, Shumpei Watanabe, Kouhei Tsumoto, Daisuke Kohda, Richard Karl Plemper, Yusuke Yanagi Takao Hashiguchi, Yoshinari Fukuda, Rei Matsuoka, Daisuke Kuroda, Marie Kubota, Yuta Shirogane, Shumpei Watanabe, Kouhei Tsumoto, Daisuke Kohda, Richard Karl Plemper, Yusuke Yanagi Takao Hashiguchi, Yoshinari Fukuda, Rei Matsuoka, Daisuke Kuroda, Marie Kubota, Yuta Shirogane, Shumpei Watanabe, Kouhei Tsumoto, Daisuke Kohda, Richard Karl Plemper, Yusuke Yanagi Structures of the prefusion form of measles virus fusion protein in complex with inhibitors. Structures of the prefusion form of measles virus fusion protein in complex with inhibitors. Structures of the prefusion form of measles virus fusion protein in complex with inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 115, 10, 2496-2501 Proceedings of the National Academy of Sciences of the United States of America, 115, 10, 2496-2501 Proceedings of the National Academy of Sciences of the United States of America, 115, 10, 2496-2501 2018/03/06 Refereed English Research paper(scientific journal) Disclose to all
Yuma Sato, Shumpei Watanabe, Yoshinari Fukuda, Takao Hashiguchi, Yusuke Yanagi, Shinji Ohno Yuma Sato, Shumpei Watanabe, Yoshinari Fukuda, Takao Hashiguchi, Yusuke Yanagi, Shinji Ohno Yuma Sato, Shumpei Watanabe, Yoshinari Fukuda, Takao Hashiguchi, Yusuke Yanagi, Shinji Ohno Cell-to-cell measles virus spread between human neurons is dependent on hemagglutinin and hyperfusogenic fusion protein Cell-to-cell measles virus spread between human neurons is dependent on hemagglutinin and hyperfusogenic fusion protein Cell-to-cell measles virus spread between human neurons is dependent on hemagglutinin and hyperfusogenic fusion protein Journal of Virology, 92, 6 Journal of Virology, 92, 6 Journal of Virology, 92, 6 2018/03/01 Refereed English Research paper(scientific journal) Disclose to all
Koga R, Kubota M, Hashiguchi T, Yanagi Y, Ohno S Koga R, Kubota M, Hashiguchi T, Yanagi Y, Ohno S Koga R, Kubota M, Hashiguchi T, Yanagi Y, Ohno S Annexin A2 Mediates the Localization of Measles Virus Matrix Protein at the Plasma Membrane. Annexin A2 Mediates the Localization of Measles Virus Matrix Protein at the Plasma Membrane. Annexin A2 Mediates the Localization of Measles Virus Matrix Protein at the Plasma Membrane. <i><b>Journal of virology</b></i> <i><b>Journal of virology</b></i> <i><b>Journal of virology</b></i> 2018/02 Refereed Disclose to all
Amandeep K. Sangha, Jinhui Dong, Lauren Williamson, Takao Hashiguchi, Erica Ollmann Saphire, James E. Crowe, Jens Meiler Amandeep K. Sangha, Jinhui Dong, Lauren Williamson, Takao Hashiguchi, Erica Ollmann Saphire, James E. Crowe, Jens Meiler Amandeep K. Sangha, Jinhui Dong, Lauren Williamson, Takao Hashiguchi, Erica Ollmann Saphire, James E. Crowe, Jens Meiler Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein STRUCTURE, 25, 12, 1820-+ STRUCTURE, 25, 12, 1820-+ STRUCTURE, 25, 12, 1820-+ 2017/12 Refereed English Research paper(scientific journal) Disclose to all
Marie Kubota, Kaoru Takeuchi, Shumpei Watanabe, Shinji Ohno, Rei Matsuoka, Daisuke Kohda, Shin-ichi Nakakita, Hiroaki Hiramatsu, Yasuo Suzuki, Tetsuo Nakayama, Tohru Terada, Kentaro Shimizu, Nobutaka Shimizu, Mitsunori Shiroishi, Yusuke Yanagi, Takao Hashiguchi Kubota M, Takeuchi K, Watanabe S, Ohno S, Matsuoka R, Kohda D, Nakakita SI, Hiramatsu H, Suzuki Y, Nakayama T, Terada T, Shimizu K, Shimizu N, Shiroishi M, Yanagi Y, Hashiguchi T, o-corresponding autho Marie Kubota, Kaoru Takeuchi, Shumpei Watanabe, Shinji Ohno, Rei Matsuoka, Daisuke Kohda, Shin-ichi Nakakita, Hiroaki Hiramatsu, Yasuo Suzuki, Tetsuo Nakayama, Tohru Terada, Kentaro Shimizu, Nobutaka Shimizu, Mitsunori Shiroishi, Yusuke Yanagi, Takao Hashiguchi Trisaccharide containing alpha 2,3-linked sialic acid is a receptor for mumps virus Trisaccharide containing α2,3-linked sialic acid is a receptor for mumps virus. Trisaccharide containing alpha 2,3-linked sialic acid is a receptor for mumps virus PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113, 41, 11579-11584 <i><b>Proc Natl Acad Sci U S A.</b></i>, 113, 41, 11579-11584 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113, 41, 11579-11584 2016/10 Refereed English Research paper(scientific journal) Disclose to all
Marnie L. Fusco, Takao Hashiguchi, Robyn Cassan, Julia E. Biggins, Charles D. Murin, Kelly L. Warfield, Sheng Li, Frederick W. Holtsberg, Sergey Shulenin, Hong Vu, Gene G. Olinger, Do H. Kim, Kevin J. Whaley, Larry Zeitlin, Andrew B. Ward, Cory Nykiforuk, M. Javad Aman, Jody Berry, Erica Ollmann Saphire Marnie L. Fusco, Takao Hashiguchi, Robyn Cassan, Julia E. Biggins, Charles D. Murin, Kelly L. Warfield, Sheng Li, Frederick W. Holtsberg, Sergey Shulenin, Hong Vu, Gene G. Olinger, Do H. Kim, Kevin J. Whaley, Larry Zeitlin, Andrew B. Ward, Cory Nykiforuk, M. Javad Aman, Jody Berry, Erica Ollmann Saphire Marnie L. Fusco, Takao Hashiguchi, Robyn Cassan, Julia E. Biggins, Charles D. Murin, Kelly L. Warfield, Sheng Li, Frederick W. Holtsberg, Sergey Shulenin, Hong Vu, Gene G. Olinger, Do H. Kim, Kevin J. Whaley, Larry Zeitlin, Andrew B. Ward, Cory Nykiforuk, M. Javad Aman, Jody Berry, Erica Ollmann Saphire Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs PLOS PATHOGENS, 11, 6, e1005016 PLOS PATHOGENS, 11, 6, e1005016 PLOS PATHOGENS, 11, 6, e1005016 2015/06 Refereed English Research paper(scientific journal) Disclose to all
Andrew I. Flyak, Philipp A. Ilinykh, Charles D. Murin, Tania Garron, Xiaoli Shen, Marnie L. Fusco, Takao Hashiguchi, Zachary A. Bornholdt, James C. Slaughter, Gopal Sapparapu, Curtis Klages, Thomas G. Ksiazek, Andrew B. Ward, Erica Ollmann Saphire, Alexander Bukreyev, James E. Crowe Andrew I. Flyak, Philipp A. Ilinykh, Charles D. Murin, Tania Garron, Xiaoli Shen, Marnie L. Fusco, Takao Hashiguchi, Zachary A. Bornholdt, James C. Slaughter, Gopal Sapparapu, Curtis Klages, Thomas G. Ksiazek, Andrew B. Ward, Erica Ollmann Saphire, Alexander Bukreyev, James E. Crowe Andrew I. Flyak, Philipp A. Ilinykh, Charles D. Murin, Tania Garron, Xiaoli Shen, Marnie L. Fusco, Takao Hashiguchi, Zachary A. Bornholdt, James C. Slaughter, Gopal Sapparapu, Curtis Klages, Thomas G. Ksiazek, Andrew B. Ward, Erica Ollmann Saphire, Alexander Bukreyev, James E. Crowe Mechanism of Human Antibody-Mediated Neutralization of Marburg Virus Mechanism of Human Antibody-Mediated Neutralization of Marburg Virus Mechanism of Human Antibody-Mediated Neutralization of Marburg Virus CELL, 160, 5, 893-903 CELL, 160, 5, 893-903 CELL, 160, 5, 893-903 2015/02 Refereed English Research paper(scientific journal) Disclose to all
Takao Hashiguchi, Marnie L. Fusco, Zachary A. Bornholdt, Jeffrey E. Lee, Andrew I. Flyak, Rei Matsuoka, Daisuke Kohda, Yusuke Yanagi, Michal Hammel, James E. Crowe, Erica Ollmann Saphire Takao Hashiguchi, Marnie L. Fusco, Zachary A. Bornholdt, Jeffrey E. Lee, Andrew I. Flyak, Rei Matsuoka, Daisuke Kohda, Yusuke Yanagi, Michal Hammel, James E. Crowe, Erica Ollmann Saphire Takao Hashiguchi, Marnie L. Fusco, Zachary A. Bornholdt, Jeffrey E. Lee, Andrew I. Flyak, Rei Matsuoka, Daisuke Kohda, Yusuke Yanagi, Michal Hammel, James E. Crowe, Erica Ollmann Saphire Structural Basis for Marburg Virus Neutralization by a Cross-Reactive Human Antibody Structural Basis for Marburg Virus Neutralization by a Cross-Reactive Human Antibody Structural Basis for Marburg Virus Neutralization by a Cross-Reactive Human Antibody CELL, 160, 5, 904-912 CELL, 160, 5, 904-912 CELL, 160, 5, 904-912 2015/02 Refereed English Research paper(scientific journal) Disclose to all
Mai Nakashima, Yuta Shirogane, Takao Hashiguchi, Yusuke Yanagi Mai Nakashima, Yuta Shirogane, Takao Hashiguchi, Yusuke Yanagi Mai Nakashima, Yuta Shirogane, Takao Hashiguchi, Yusuke Yanagi Mutations in the putative dimer-dimer interfaces of the measles virus hemagglutinin head domain affect membrane fusion triggering. Mutations in the putative dimer-dimer interfaces of the measles virus hemagglutinin head domain affect membrane fusion triggering. Mutations in the putative dimer-dimer interfaces of the measles virus hemagglutinin head domain affect membrane fusion triggering. The Journal of biological chemistry, 288, 12, 8085-91 The Journal of biological chemistry, 288, 12, 8085-91 The Journal of biological chemistry, 288, 12, 8085-91 2013/03/22 Refereed English Disclose to all
Takao Hashiguchi, Toyoyuki Ose, Marie Kubota, Nobuo Maita, Jun Kamishikiryo, Katsumi Maenaka, Yusuke Yanagi Takao Hashiguchi, Toyoyuki Ose, Marie Kubota, Nobuo Maita, Jun Kamishikiryo, Katsumi Maenaka, Yusuke Yanagi Takao Hashiguchi, Toyoyuki Ose, Marie Kubota, Nobuo Maita, Jun Kamishikiryo, Katsumi Maenaka, Yusuke Yanagi Crystallization Strategy for the Glycoprotein-Receptor Complex Between Measles Virus Hemagglutinin and Its Cellular Receptor SLAM Crystallization Strategy for the Glycoprotein-Receptor Complex Between Measles Virus Hemagglutinin and Its Cellular Receptor SLAM Crystallization Strategy for the Glycoprotein-Receptor Complex Between Measles Virus Hemagglutinin and Its Cellular Receptor SLAM PROTEIN AND PEPTIDE LETTERS, 19, 4, 468-473 PROTEIN AND PEPTIDE LETTERS, 19, 4, 468-473 PROTEIN AND PEPTIDE LETTERS, 19, 4, 468-473 2012/04 Refereed English Research paper(scientific journal) Disclose to all
Shridhar Bale, Joao M. Dias, Marnie L. Fusco, Takao Hashiguchi, Anthony C. Wong, Tong Liu, Ana I. Keuhne, Sheng Li, Virgil L. Woods, Kartik Chandran, John M. Dye, Erica Ollmann Saphire Shridhar Bale, Joao M. Dias, Marnie L. Fusco, Takao Hashiguchi, Anthony C. Wong, Tong Liu, Ana I. Keuhne, Sheng Li, Virgil L. Woods, Kartik Chandran, John M. Dye, Erica Ollmann Saphire Shridhar Bale, Joao M. Dias, Marnie L. Fusco, Takao Hashiguchi, Anthony C. Wong, Tong Liu, Ana I. Keuhne, Sheng Li, Virgil L. Woods, Kartik Chandran, John M. Dye, Erica Ollmann Saphire Structural Basis for Differential Neutralization of Ebolaviruses Structural Basis for Differential Neutralization of Ebolaviruses Structural Basis for Differential Neutralization of Ebolaviruses VIRUSES-BASEL, 4, 4, 447-470 VIRUSES-BASEL, 4, 4, 447-470 VIRUSES-BASEL, 4, 4, 447-470 2012/04 Refereed English Research paper(scientific journal) Disclose to all
Daniel Olal, Ana I. Kuehne, Shridhar Bale, Peter Halfmann, Takao Hashiguchi, Marnie L. Fusco, Jeffrey E. Lee, Liam B. King, Yoshihiro Kawaoka, John M. Dye, Erica Ollmann Saphire Daniel Olal, Ana I. Kuehne, Shridhar Bale, Peter Halfmann, Takao Hashiguchi, Marnie L. Fusco, Jeffrey E. Lee, Liam B. King, Yoshihiro Kawaoka, John M. Dye, Erica Ollmann Saphire Daniel Olal, Ana I. Kuehne, Shridhar Bale, Peter Halfmann, Takao Hashiguchi, Marnie L. Fusco, Jeffrey E. Lee, Liam B. King, Yoshihiro Kawaoka, John M. Dye, Erica Ollmann Saphire Structure of an Antibody in Complex with Its Mucin Domain Linear Epitope That Is Protective against Ebola Virus Structure of an Antibody in Complex with Its Mucin Domain Linear Epitope That Is Protective against Ebola Virus Structure of an Antibody in Complex with Its Mucin Domain Linear Epitope That Is Protective against Ebola Virus JOURNAL OF VIROLOGY, 86, 5, 2809-2816 JOURNAL OF VIROLOGY, 86, 5, 2809-2816 JOURNAL OF VIROLOGY, 86, 5, 2809-2816 2012/03 Refereed English Research paper(scientific journal) Disclose to all
Maenaka K, Hashiguchi T, Yanagi Y Maenaka K, Hashiguchi T, Yanagi Y Maenaka K, Hashiguchi T, Yanagi Y [Structural basis for measles virus-receptor recognition and its functional implications for viral entry and vaccination]. [Structural basis for measles virus-receptor recognition and its functional implications for viral entry and vaccination]. [Structural basis for measles virus-receptor recognition and its functional implications for viral entry and vaccination]. Nihon rinsho. Japanese journal of clinical medicine, 70, 4, 695-703 Nihon rinsho. Japanese journal of clinical medicine, 70, 4, 695-703 Nihon rinsho. Japanese journal of clinical medicine, 70, 4, 695-703 2012 Refereed Disclose to all
Takao Hashiguchi, Toyoyuki Ose, Marie Kubota, Nobuo Maita, Jun Kamishikiryo, Katsumi Maenaka, Yusuke Yanagi Takao Hashiguchi, Toyoyuki Ose, Marie Kubota, Nobuo Maita, Jun Kamishikiryo, Katsumi Maenaka, Yusuke Yanagi Takao Hashiguchi, Toyoyuki Ose, Marie Kubota, Nobuo Maita, Jun Kamishikiryo, Katsumi Maenaka, Yusuke Yanagi Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM NATURE STRUCTURAL & MOLECULAR BIOLOGY, 18, 2, 135-U191 NATURE STRUCTURAL & MOLECULAR BIOLOGY, 18, 2, 135-U191 NATURE STRUCTURAL & MOLECULAR BIOLOGY, 18, 2, 135-U191 2011/02 Refereed English Research paper(scientific journal) Disclose to all
Takao Hashiguchi, Katsumi Maenaka, Yusuke Yanagi Takao Hashiguchi, Katsumi Maenaka, Yusuke Yanagi Takao Hashiguchi, Katsumi Maenaka, Yusuke Yanagi Measles virus hemagglutinin: structural insights into cell entry and measles vaccine Measles virus hemagglutinin: structural insights into cell entry and measles vaccine Measles virus hemagglutinin: structural insights into cell entry and measles vaccine FRONTIERS IN MICROBIOLOGY, 2, 247 FRONTIERS IN MICROBIOLOGY, 2, 247 FRONTIERS IN MICROBIOLOGY, 2, 247 2011 Refereed English Disclose to all
Y. Yanagi, M. Takeda, S. Ohno, T. Hashiguchi Y. Yanagi, M. Takeda, S. Ohno, T. Hashiguchi Y. Yanagi, M. Takeda, S. Ohno, T. Hashiguchi Measles Virus Receptors Measles Virus Receptors Measles Virus Receptors MEASLES: HISTORY AND BASIC BIOLOGY, 329, 13-30 MEASLES: HISTORY AND BASIC BIOLOGY, 329, 13-30 MEASLES: HISTORY AND BASIC BIOLOGY, 329, 13-30 2009 Refereed English Disclose to all
Maino Tahara, Makoto Takeda, Yuta Shirogane, Takao Hashiguchi, Shinji Ohno, Yusuke Yanagi Maino Tahara, Makoto Takeda, Yuta Shirogane, Takao Hashiguchi, Shinji Ohno, Yusuke Yanagi Maino Tahara, Makoto Takeda, Yuta Shirogane, Takao Hashiguchi, Shinji Ohno, Yusuke Yanagi Measles virus infects both polarized epithelial and immune cells by using distinctive receptor-binding sites on its hemagglutinin Measles virus infects both polarized epithelial and immune cells by using distinctive receptor-binding sites on its hemagglutinin Measles virus infects both polarized epithelial and immune cells by using distinctive receptor-binding sites on its hemagglutinin JOURNAL OF VIROLOGY, 82, 9, 4630-4637 JOURNAL OF VIROLOGY, 82, 9, 4630-4637 JOURNAL OF VIROLOGY, 82, 9, 4630-4637 2008/05 Refereed English Research paper(scientific journal) Disclose to all
Chanakha K. Navaratnarajah, Sompong Vongpunsawad, Numan Oezguen, Thilo Stehle, Werner Braun, Takao Hashiguchi, Katsumi Maenaka, Yusuke Yanagi, Roberto Cattaneo Chanakha K. Navaratnarajah, Sompong Vongpunsawad, Numan Oezguen, Thilo Stehle, Werner Braun, Takao Hashiguchi, Katsumi Maenaka, Yusuke Yanagi, Roberto Cattaneo Chanakha K. Navaratnarajah, Sompong Vongpunsawad, Numan Oezguen, Thilo Stehle, Werner Braun, Takao Hashiguchi, Katsumi Maenaka, Yusuke Yanagi, Roberto Cattaneo Dynamic interaction of the measles virus hemagglutinin with its receptor signaling lymphocytic activation molecule (SLAM, CD150) Dynamic interaction of the measles virus hemagglutinin with its receptor signaling lymphocytic activation molecule (SLAM, CD150) Dynamic interaction of the measles virus hemagglutinin with its receptor signaling lymphocytic activation molecule (SLAM, CD150) JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 17, 11763-11771 JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 17, 11763-11771 JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 17, 11763-11771 2008/04 Refereed English Research paper(scientific journal) Disclose to all
Takao Hashiguchi, Mizuho Kajikawa, Maita Nobuo, Makoto Takeda, Kimiko Kuroki, Kaori Sasaki, Daisuke Kohda, Yusuke Yanagi, Katsumi Maenaka Takao Hashiguchi, Mizuho Kajikawa, Maita Nobuo, Makoto Takeda, Kimiko Kuroki, Kaori Sasaki, Daisuke Kohda, Yusuke Yanagi, Katsumi Maenaka Takao Hashiguchi, Mizuho Kajikawa, Maita Nobuo, Makoto Takeda, Kimiko Kuroki, Kaori Sasaki, Daisuke Kohda, Yusuke Yanagi, Katsumi Maenaka Homogeneous sugar modification improves crystallization of measles virus hemagglutinin Homogeneous sugar modification improves crystallization of measles virus hemagglutinin Homogeneous sugar modification improves crystallization of measles virus hemagglutinin JOURNAL OF VIROLOGICAL METHODS, 149, 1, 171-174 JOURNAL OF VIROLOGICAL METHODS, 149, 1, 171-174 JOURNAL OF VIROLOGICAL METHODS, 149, 1, 171-174 2008/04 Refereed English Research paper(scientific journal) Disclose to all
Takao Hashiguchi, Mizuho Kajikawa, Nobuo Maita, Makoto Takeda, Kimiko Kuroki, Kaori Sasaki, Daisuke Kohda, Yusuke Yanagi, Katsumi Maenaka Takao Hashiguchi, Mizuho Kajikawa, Nobuo Maita, Makoto Takeda, Kimiko Kuroki, Kaori Sasaki, Daisuke Kohda, Yusuke Yanagi, Katsumi Maenaka Takao Hashiguchi, Mizuho Kajikawa, Nobuo Maita, Makoto Takeda, Kimiko Kuroki, Kaori Sasaki, Daisuke Kohda, Yusuke Yanagi, Katsumi Maenaka Crystal structure of measles virus hemagglutinin provides insight into effective vaccines Crystal structure of measles virus hemagglutinin provides insight into effective vaccines Crystal structure of measles virus hemagglutinin provides insight into effective vaccines PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104, 49, 19535-19540 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104, 49, 19535-19540 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104, 49, 19535-19540 2007/12 Refereed English Research paper(scientific journal) Disclose to all
Makoto Takeda, Maino Tahara, Takao Hashiguchi, Takeshi A. Sato, Fumiaki Jinnouchi, Shoko Ueki, Shinji Ohno, Yusuke Yanagi Makoto Takeda, Maino Tahara, Takao Hashiguchi, Takeshi A. Sato, Fumiaki Jinnouchi, Shoko Ueki, Shinji Ohno, Yusuke Yanagi Makoto Takeda, Maino Tahara, Takao Hashiguchi, Takeshi A. Sato, Fumiaki Jinnouchi, Shoko Ueki, Shinji Ohno, Yusuke Yanagi A human lung carcinoma cell line supports efficient measles virus growth and syncytium formation via a SLAM- and CD46-Independent mechanism A human lung carcinoma cell line supports efficient measles virus growth and syncytium formation via a SLAM- and CD46-Independent mechanism A human lung carcinoma cell line supports efficient measles virus growth and syncytium formation via a SLAM- and CD46-Independent mechanism JOURNAL OF VIROLOGY, 81, 21, 12091-12096 JOURNAL OF VIROLOGY, 81, 21, 12091-12096 JOURNAL OF VIROLOGY, 81, 21, 12091-12096 2007/11 Refereed English Research paper(scientific journal) Disclose to all
Maino Tahara, Makoto Takeda, Fumio Seki, Takao Hashiguchi, Yusuke Yanagi Maino Tahara, Makoto Takeda, Fumio Seki, Takao Hashiguchi, Yusuke Yanagi Maino Tahara, Makoto Takeda, Fumio Seki, Takao Hashiguchi, Yusuke Yanagi Multiple amino acid substitutions in hemagglutinin are necessary for wild-type measles virus to acquire the ability to use receptor CD46 efficiently Multiple amino acid substitutions in hemagglutinin are necessary for wild-type measles virus to acquire the ability to use receptor CD46 efficiently Multiple amino acid substitutions in hemagglutinin are necessary for wild-type measles virus to acquire the ability to use receptor CD46 efficiently JOURNAL OF VIROLOGY, 81, 6, 2564-2572 JOURNAL OF VIROLOGY, 81, 6, 2564-2572 JOURNAL OF VIROLOGY, 81, 6, 2564-2572 2007/03 Refereed English Research paper(scientific journal) Disclose to all
Ryo Kurita, Erika Sasaki, Tomoko Yokoo, Takashi Hiroyama, Kashiya Takasugi, Hideyuki Imoto, Kiyoko Izawa, Yan Dong, Takao Hashiguchi, Yasushi Soda, Toyoki Maeda, Youko Suehiro, Yoshikuni Tanioka, Yukoh Nakazaki, Kenzaburo Tani Ryo Kurita, Erika Sasaki, Tomoko Yokoo, Takashi Hiroyama, Kashiya Takasugi, Hideyuki Imoto, Kiyoko Izawa, Yan Dong, Takao Hashiguchi, Yasushi Soda, Toyoki Maeda, Youko Suehiro, Yoshikuni Tanioka, Yukoh Nakazaki, Kenzaburo Tani Ryo Kurita, Erika Sasaki, Tomoko Yokoo, Takashi Hiroyama, Kashiya Takasugi, Hideyuki Imoto, Kiyoko Izawa, Yan Dong, Takao Hashiguchi, Yasushi Soda, Toyoki Maeda, Youko Suehiro, Yoshikuni Tanioka, Yukoh Nakazaki, Kenzaburo Tani Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells STEM CELLS, 24, 9, 2014-2022 STEM CELLS, 24, 9, 2014-2022 STEM CELLS, 24, 9, 2014-2022 2006/09 Refereed English Research paper(scientific journal) Disclose to all
M Takeda, Y Nakatsu, S Ohno, F Seki, M Tahara, T Hashiguchi, Y Yanagi M Takeda, Y Nakatsu, S Ohno, F Seki, M Tahara, T Hashiguchi, Y Yanagi M Takeda, Y Nakatsu, S Ohno, F Seki, M Tahara, T Hashiguchi, Y Yanagi Generation of measles virus with a segmented RNA genome Generation of measles virus with a segmented RNA genome Generation of measles virus with a segmented RNA genome JOURNAL OF VIROLOGY, 80, 9, 4242-4248 JOURNAL OF VIROLOGY, 80, 9, 4242-4248 JOURNAL OF VIROLOGY, 80, 9, 4242-4248 2006/05 Refereed English Research paper(scientific journal) Disclose to all

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Title language:
Misc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
田所高志, LUBNA Jahan Mst, 伊藤由梨, 田原舞乃, 橋口隆生, 竹田誠, 福原秀雄, 前仲勝実 田所高志, LUBNA Jahan Mst, 伊藤由梨, 田原舞乃, 橋口隆生, 竹田誠, 福原秀雄, 前仲勝実 田所高志, LUBNA Jahan Mst, 伊藤由梨, 田原舞乃, 橋口隆生, 竹田誠, 福原秀雄, 前仲勝実 麻疹中和抗体のフラグメント化と物理化学的特性の解析 麻疹中和抗体のフラグメント化と物理化学的特性の解析 麻疹中和抗体のフラグメント化と物理化学的特性の解析 日本細胞生物学会大会(Web), 71st, ROMBUNNO.2P‐209 (WEB ONLY) 日本細胞生物学会大会(Web), 71st, ROMBUNNO.2P‐209 (WEB ONLY) 日本細胞生物学会大会(Web), 71st, ROMBUNNO.2P‐209 (WEB ONLY) 2019 Japanese Disclose to all
橋口隆生 橋口隆生 橋口隆生 おたふくかぜはどのように感染発症するのでしょうか,なぜワクチンが有効なのでしょうか おたふくかぜはどのように感染発症するのでしょうか,なぜワクチンが有効なのでしょうか おたふくかぜはどのように感染発症するのでしょうか,なぜワクチンが有効なのでしょうか 外来小児科, 21, 2, 317 外来小児科, 21, 2, 317 外来小児科, 21, 2, 317 2018/07/20 Japanese Disclose to all
Takashi Tadokoro, Lubna Mst Jahan, Atsutoshi Imai, Natsumi Sugimura, Koki Yoshida, Mizuki Saito, Yuri Ito, Surui Chen, Takao Hashiguchi, Yusuke Yanagi, Maino Tahara, Makoto Takeda, Hideo Fukuhara, Katsumi Maneaka Takashi Tadokoro, Lubna Mst Jahan, Atsutoshi Imai, Natsumi Sugimura, Koki Yoshida, Mizuki Saito, Yuri Ito, Surui Chen, Takao Hashiguchi, Yusuke Yanagi, Maino Tahara, Makoto Takeda, Hideo Fukuhara, Katsumi Maneaka Takashi Tadokoro, Lubna Mst Jahan, Atsutoshi Imai, Natsumi Sugimura, Koki Yoshida, Mizuki Saito, Yuri Ito, Surui Chen, Takao Hashiguchi, Yusuke Yanagi, Maino Tahara, Makoto Takeda, Hideo Fukuhara, Katsumi Maneaka Development of single chain Fv of neutralizing antibody to measles virus targeting the receptor binding site of hemagglutinin Development of single chain Fv of neutralizing antibody to measles virus targeting the receptor binding site of hemagglutinin Development of single chain Fv of neutralizing antibody to measles virus targeting the receptor binding site of hemagglutinin PROTEIN SCIENCE, 25, 72-72 PROTEIN SCIENCE, 25, 72-72 PROTEIN SCIENCE, 25, 72-72 2016/10 English Research paper, summary (international conference) Disclose to all
Erica Ollmann Saphire, Zach Bornholdt, Marnie Fusco, Dafna Abelson, Takao Hashiguchi, Jeffrey Lee, Yoshihiro Kawaoka, John Dye, James Crowe Erica Ollmann Saphire, Zach Bornholdt, Marnie Fusco, Dafna Abelson, Takao Hashiguchi, Jeffrey Lee, Yoshihiro Kawaoka, John Dye, James Crowe Erica Ollmann Saphire, Zach Bornholdt, Marnie Fusco, Dafna Abelson, Takao Hashiguchi, Jeffrey Lee, Yoshihiro Kawaoka, John Dye, James Crowe The Molecular Tool-Kit of Viral Hemorrhagic Fevers The Molecular Tool-Kit of Viral Hemorrhagic Fevers The Molecular Tool-Kit of Viral Hemorrhagic Fevers FASEB JOURNAL, 29 FASEB JOURNAL, 29 FASEB JOURNAL, 29 2015/04 English Research paper, summary (international conference) Disclose to all
橋口隆生, 白銀勇太, 前仲勝実, 柳雄介 橋口隆生, 白銀勇太, 前仲勝実, 柳雄介 橋口隆生, 白銀勇太, 前仲勝実, 柳雄介 麻疹ウイルスと受容体SLAMの相互作用と膜融合 麻疹ウイルスと受容体SLAMの相互作用と膜融合 麻疹ウイルスと受容体SLAMの相互作用と膜融合 日本ウイルス学会学術集会プログラム・抄録集, 58th, 147 日本ウイルス学会学術集会プログラム・抄録集, 58th, 147 日本ウイルス学会学術集会プログラム・抄録集, 58th, 147 2010/10/15 Japanese Disclose to all
橋口隆生, 尾瀬農之, 上敷領淳, 柳雄介, 前仲勝実 橋口隆生, 尾瀬農之, 上敷領淳, 柳雄介, 前仲勝実 橋口隆生, 尾瀬農之, 上敷領淳, 柳雄介, 前仲勝実 麻疹ウイルスによる細胞侵入機構の構造基盤 麻疹ウイルスによる細胞侵入機構の構造基盤 麻疹ウイルスによる細胞侵入機構の構造基盤 日本蛋白質科学会年会プログラム・要旨集, 10th, 32 日本蛋白質科学会年会プログラム・要旨集, 10th, 32 日本蛋白質科学会年会プログラム・要旨集, 10th, 32 2010/05/15 Japanese Disclose to all
橋口隆生, 尾瀬農之, 上敷領淳, 竹田誠, 前仲勝実, 柳雄介 橋口隆生, 尾瀬農之, 上敷領淳, 竹田誠, 前仲勝実, 柳雄介 橋口隆生, 尾瀬農之, 上敷領淳, 竹田誠, 前仲勝実, 柳雄介 麻疹ウイルスHタンパク質と受容体SLAMの複合体の結晶構造と麻疹ウイルスの細胞侵入機構 麻疹ウイルスHタンパク質と受容体SLAMの複合体の結晶構造と麻疹ウイルスの細胞侵入機構 麻疹ウイルスHタンパク質と受容体SLAMの複合体の結晶構造と麻疹ウイルスの細胞侵入機構 日本ウイルス学会学術集会プログラム・抄録集, 57th, 149 日本ウイルス学会学術集会プログラム・抄録集, 57th, 149 日本ウイルス学会学術集会プログラム・抄録集, 57th, 149 2009/10/01 Japanese Disclose to all
橋口隆生, 橋口隆生, 竹田誠, 田原舞乃, 池亀聡, 大野真治, 柳雄介 橋口隆生, 橋口隆生, 竹田誠, 田原舞乃, 池亀聡, 大野真治, 柳雄介 橋口隆生, 橋口隆生, 竹田誠, 田原舞乃, 池亀聡, 大野真治, 柳雄介 麻疹ウイルスHタンパク質による受容体認識の構造基盤 麻疹ウイルスHタンパク質による受容体認識の構造基盤 麻疹ウイルスHタンパク質による受容体認識の構造基盤 日本ウイルス学会学術集会プログラム・抄録集, 56th, 124 日本ウイルス学会学術集会プログラム・抄録集, 56th, 124 日本ウイルス学会学術集会プログラム・抄録集, 56th, 124 2008/10/01 Japanese Disclose to all
橋口隆生, 梶川瑞穂, 真板宣夫, 竹田誠, 黒木喜美子, 佐々木香織, 柳雄介, 前仲勝実 橋口隆生, 梶川瑞穂, 真板宣夫, 竹田誠, 黒木喜美子, 佐々木香織, 柳雄介, 前仲勝実 橋口隆生, 梶川瑞穂, 真板宣夫, 竹田誠, 黒木喜美子, 佐々木香織, 柳雄介, 前仲勝実 麻疹ウイルスHタンパク質のX線結晶構造解析 麻疹ウイルスHタンパク質のX線結晶構造解析 麻疹ウイルスHタンパク質のX線結晶構造解析 補体シンポジウム講演集, 45th, 61 補体シンポジウム講演集, 45th, 61 補体シンポジウム講演集, 45th, 61 2008/07 Japanese Disclose to all
橋口隆生, 久保田万理恵, 竹田誠, 大野真治, 柳雄介 橋口隆生, 久保田万理恵, 竹田誠, 大野真治, 柳雄介 橋口隆生, 久保田万理恵, 竹田誠, 大野真治, 柳雄介 麻疹ウイルス感染におけるレセプターSLAM上の糖鎖の意義 麻疹ウイルス感染におけるレセプターSLAM上の糖鎖の意義 麻疹ウイルス感染におけるレセプターSLAM上の糖鎖の意義 日本ウイルス学会学術集会プログラム・抄録集, 55th, 153 日本ウイルス学会学術集会プログラム・抄録集, 55th, 153 日本ウイルス学会学術集会プログラム・抄録集, 55th, 153 2007/10/01 Japanese Disclose to all
橋口隆生, 竹田誠, 柳雄介 橋口隆生, 竹田誠, 柳雄介 橋口隆生, 竹田誠, 柳雄介 X線結晶構造解析による麻疹ウイルスHタンパク質のレセプター認識の構造基盤 X線結晶構造解析による麻疹ウイルスHタンパク質のレセプター認識の構造基盤 X線結晶構造解析による麻疹ウイルスHタンパク質のレセプター認識の構造基盤 日本ウイルス学会学術集会プログラム・抄録集, 55th, 154 日本ウイルス学会学術集会プログラム・抄録集, 55th, 154 日本ウイルス学会学術集会プログラム・抄録集, 55th, 154 2007/10/01 Japanese Disclose to all

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Title language:
Conference Activities & Talks
Title Title(Japanese) Title(English) Conference Conference(Japanese) Conference(English) Promotor Promotor(Japanese) Promotor(English) Date Language Assortment Disclose
Structure-guided and computer-aided drug development to ameliorate persistent measles virus infection in the central nervous system[Invited] Structure-guided and computer-aided drug development to ameliorate persistent measles virus infection in the central nervous system [Invited] Structure-guided and computer-aided drug development to ameliorate persistent measles virus infection in the central nervous system [Invited] Japan-UK Workshop on Infectious Disease Research(AMED-英国大使館主催) Japan-UK Workshop on Infectious Disease Research(AMED-英国大使館主催) Japan-UK Workshop on Infectious Disease Research(AMED-英国大使館主催) 2019/01/21 English Symposium workshop panel(nominated) Disclose to all
小児ウイルス感染症とその感染阻害機構[Invited] 小児ウイルス感染症とその感染阻害機構 [Invited] 第5回 外力支援型バイオアッセイ技術コンソーシアム 技術セミナー・技術交流会(産総研) 第5回 外力支援型バイオアッセイ技術コンソーシアム 技術セミナー・技術交流会(産総研) 2019/01/11 Japanese Disclose to all
おたふくかぜ・麻疹(はしか)の感染制御に向けて[Invited] おたふくかぜ・麻疹(はしか)の感染制御に向けて [Invited] 埼玉大学 先端産業国際ラボラトリー 第8回ワークショップ-感染症に挑む 埼玉大学 先端産業国際ラボラトリー 第8回ワークショップ-感染症に挑む 2018/12/12 Japanese Symposium workshop panel(nominated) Disclose to all
Drug-repositioning screening for anti-viral therapeutics of mumps virus infection Drug-repositioning screening for anti-viral therapeutics of mumps virus infection Drug-repositioning screening for anti-viral therapeutics of mumps virus infection The 66th Annual meeting of the Japanese Society for Virology The 66th Annual meeting of the Japanese Society for Virology The 66th Annual meeting of the Japanese Society for Virology 2018/10/30 English Oral presentation(general) Disclose to all
原子の世界でウイルスを視る、制御する[Invited] 原子の世界でウイルスを視る、制御する [Invited] ラブラボ 2018(東京大学医科学研究所) ラブラボ 2018(東京大学医科学研究所) 2018/08/03 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
Measles virus-mediated membrane fusion linked with CNS disorders Measles virus-mediated membrane fusion linked with CNS disorders Measles virus-mediated membrane fusion linked with CNS disorders EMBO Workshop, Membrane fusion in health and disease Cambridge EMBO Workshop, Membrane fusion in health and disease Cambridge EMBO Workshop, Membrane fusion in health and disease Cambridge 2018/06/25 English Symposium workshop panel(public) Disclose to all
モノネガウイルスの細胞侵入およびその阻害機構の研究と創薬への展開[Invited] モノネガウイルスの細胞侵入およびその阻害機構の研究と創薬への展開 [Invited] モノネガウイルスの細胞侵入およびその阻害機構の研究と創薬への展開 [Invited] AMED 新興再興事業・J-GRID合同シンポジウム 感染症研究連携のフロンティア AMED 新興再興事業・J-GRID合同シンポジウム 感染症研究連携のフロンティア AMED 新興再興事業・J-GRID合同シンポジウム 感染症研究連携のフロンティア 2018/03/23 Japanese Symposium workshop panel(nominated) Disclose to all
Molecular dissection of virus entry and its inhibition by antibodies/inhibitors[Invited] Molecular dissection of virus entry and its inhibition by antibodies/inhibitors [Invited] Molecular dissection of virus entry and its inhibition by antibodies/inhibitors [Invited] Immunology at the Forefront - The 9th International Symposium of IFReC Immunology at the Forefront - The 9th International Symposium of IFReC Immunology at the Forefront - The 9th International Symposium of IFReC 2018/01/26 English Symposium workshop panel(nominated) Disclose to all
構造生物学的手法を活用したRNAウイルスの細胞侵入機構および抗体による中和機構の研究[Invited] 構造生物学的手法を活用したRNAウイルスの細胞侵入機構および抗体による中和機構の研究 [Invited] 第4回タンパク質X線溶液散乱講習会 第4回タンパク質X線溶液散乱講習会 2017/12/12 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
Molecular basis for Mononegavirus entry and inhibitions by antibodies/inhibitors[Invited] Molecular basis for Mononegavirus entry and inhibitions by antibodies/inhibitors [Invited] Molecular basis for Mononegavirus entry and inhibitions by antibodies/inhibitors [Invited] The 16th Awaji International Forum on Infection and Immunity The 16th Awaji International Forum on Infection and Immunity The 16th Awaji International Forum on Infection and Immunity 2017/09/06 English Symposium workshop panel(nominated) Disclose to all
ムンプスウイルスの細胞侵入機構と糖鎖受容体[Invited] ムンプスウイルスの細胞侵入機構と糖鎖受容体 [Invited] 第31回インフルエンザ研究者交流の会シンポジウム 第31回インフルエンザ研究者交流の会シンポジウム 2017/06/08 Japanese Symposium workshop panel(nominated) Disclose to all
糖鎖受容体を介したムンプスウイルス細胞侵入メカニズムの構造生物学的・ウイルス学的解析 糖鎖受容体を介したムンプスウイルス細胞侵入メカニズムの構造生物学的・ウイルス学的解析 The 6th Negative Strand Virus-Japan Symposium The 6th Negative Strand Virus-Japan Symposium 2017/01/16 Japanese Oral presentation(general) Disclose to all
Characterization of Neutralizing Antibodies against Measles Virus Characterization of Neutralizing Antibodies against Measles Virus Characterization of Neutralizing Antibodies against Measles Virus The 64th Annual meeting of the Japanese Society for Virology The 64th Annual meeting of the Japanese Society for Virology The 64th Annual meeting of the Japanese Society for Virology 2016/10/24 English Oral presentation(general) Disclose to all
Molecular basis for negative-strand RNA virus entry and neutralization by antibodies[Invited] Molecular basis for negative-strand RNA virus entry and neutralization by antibodies [Invited] Molecular basis for negative-strand RNA virus entry and neutralization by antibodies [Invited] The 64th Annual meeting of the Japanese Society for Virology The 64th Annual meeting of the Japanese Society for Virology The 64th Annual meeting of the Japanese Society for Virology 2016/10/24 English Public discourse, seminar, tutorial, course, lecture and others Disclose to all
Tetrameric interaction of the mumps virus hemagglutinin-neuraminidase head domain is critical for triggering membrane fusion Tetrameric interaction of the mumps virus hemagglutinin-neuraminidase head domain is critical for triggering membrane fusion Tetrameric interaction of the mumps virus hemagglutinin-neuraminidase head domain is critical for triggering membrane fusion The 64th Annual meeting of the Japanese Society for Virology The 64th Annual meeting of the Japanese Society for Virology The 64th Annual meeting of the Japanese Society for Virology 2016/10/23 English Oral presentation(general) Disclose to all
Linear saccharide moiety containing α2,3-linked sialic acid, rather than the sialic acid alone, constitutes a receptor for mumps virus Linear saccharide moiety containing α2,3-linked sialic acid, rather than the sialic acid alone, constitutes a receptor for mumps virus Linear saccharide moiety containing α2,3-linked sialic acid, rather than the sialic acid alone, constitutes a receptor for mumps virus The 64th Annual meeting of the Japanese Society for Virology The 64th Annual meeting of the Japanese Society for Virology The 64th Annual meeting of the Japanese Society for Virology 2016/10/23 English Oral presentation(general) Disclose to all
Structural basis for Ebola and Marburg virus neutralization by antibodies Structural basis for Ebola and Marburg virus neutralization by antibodies Structural basis for Ebola and Marburg virus neutralization by antibodies 第16回日本蛋白質科学会 第16回日本蛋白質科学会 2016/06/07 Japanese Poster presentation Disclose to all
Inhibitory mechanisms of anti-filovirus antibodies on Marburg and Ebola virus entry[Invited] Inhibitory mechanisms of anti-filovirus antibodies on Marburg and Ebola virus entry [Invited] Inhibitory mechanisms of anti-filovirus antibodies on Marburg and Ebola virus entry [Invited] Institute for Protein Research(IPR) International Seminar IPR / CRED / PDIS Joint Seminar Institute for Protein Research(IPR) International Seminar IPR / CRED / PDIS Joint Seminar Institute for Protein Research(IPR) International Seminar IPR / CRED / PDIS Joint Seminar 2016/01/12 English Symposium workshop panel(nominated) Disclose to all
Structural basis for filovirus neutralization by antibodies[Invited] Structural basis for filovirus neutralization by antibodies [Invited] Structural basis for filovirus neutralization by antibodies [Invited] The 63rd Annual meeting of the Japanese Society for Virology The 63rd Annual meeting of the Japanese Society for Virology The 63rd Annual meeting of the Japanese Society for Virology 2015/11/25 English Symposium workshop panel(nominated) Disclose to all
抗体によるエボラ・マールブルグウイルスの中和の構造基盤[Invited] 抗体によるエボラ・マールブルグウイルスの中和の構造基盤 [Invited] 第2回感染コンピテンシー若手研究会 第2回感染コンピテンシー若手研究会 2015/07/17 Japanese Symposium workshop panel(nominated) Disclose to all
抗体によるフィロウイルスの中和の構造基盤[Invited] 抗体によるフィロウイルスの中和の構造基盤 [Invited] 感染症国際研究センター/全国共同利用・共同研究拠点 若手ジョイントシンポジウム 感染症国際研究センター/全国共同利用・共同研究拠点 若手ジョイントシンポジウム 2015/02/18 Japanese Symposium workshop panel(nominated) Disclose to all
マールブルグウイルス糖蛋白質 GP とヒト由来抗体の X 線結晶構造 マールブルグウイルス糖蛋白質 GP とヒト由来抗体の X 線結晶構造 第62回 日本ウイルス学会 第62回 日本ウイルス学会 2014/11/10 Japanese Oral presentation(general) Disclose to all
モノネガウイルスワクチンの有効性と新規開発の構造基盤[Invited] モノネガウイルスワクチンの有効性と新規開発の構造基盤 [Invited] 感染・炎症・免疫・発癌 (北海道大学遺伝子病制御研究所) 感染・炎症・免疫・発癌 (北海道大学遺伝子病制御研究所) 2014/07/04 Japanese Symposium workshop panel(nominated) Disclose to all
マールブルグウイルスの細胞侵入の構造基盤 マールブルグウイルスの細胞侵入の構造基盤 第61回 日本ウイルス学会 第61回 日本ウイルス学会 2013/11/11 Japanese Oral presentation(general) Disclose to all
Structures of measles virus hemagglutinin provide virus entry and effective measles vaccine[Invited] Structures of measles virus hemagglutinin provide virus entry and effective measles vaccine [Invited] Structures of measles virus hemagglutinin provide virus entry and effective measles vaccine [Invited] The 12th Awaji International Forum on Infection and Immunity The 12th Awaji International Forum on Infection and Immunity The 12th Awaji International Forum on Infection and Immunity 2013/09/11 English Symposium workshop panel(nominated) Disclose to all
Structural and functional insight into measles virus hemagglutinin Structural and functional insight into measles virus hemagglutinin Structural and functional insight into measles virus hemagglutinin 7th International Conference on Structural Genomics (ICSG2013-SLS) 7th International Conference on Structural Genomics (ICSG2013-SLS) 7th International Conference on Structural Genomics (ICSG2013-SLS) 2013/07/30 English Poster presentation Disclose to all
Crystal structure of the measles virus hemagglutinin sheds light on its interaction with cellular receptors and antibodies Crystal structure of the measles virus hemagglutinin sheds light on its interaction with cellular receptors and antibodies Crystal structure of the measles virus hemagglutinin sheds light on its interaction with cellular receptors and antibodies The 27th Annual Meeting of American Scociety for Virology The 27th Annual Meeting of American Scociety for Virology The 27th Annual Meeting of American Scociety for Virology 2008/07 English Oral presentation(general) Disclose to all

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Title language:
Books etc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Publisher Publisher(Japanese) Publisher(English) Publication date Language Type Disclose
橋口隆生 橋口隆生 最先端微生物学研究に基づいた疾病対策の試み X線結晶構造に基づくパラミクソウイルスの細胞侵入阻害機構と創薬への展開 最先端微生物学研究に基づいた疾病対策の試み X線結晶構造に基づくパラミクソウイルスの細胞侵入阻害機構と創薬への展開 獣医畜産新報 獣医畜産新報 2018/06 Disclose to all
橋口隆生 橋口隆生 RNAウイルスの細胞侵入機構の構造基盤の解明 RNAウイルスの細胞侵入機構の構造基盤の解明 感染・炎症・免疫 感染・炎症・免疫 2017/10 Disclose to all
橋口隆生 橋口隆生 マイナス鎖RNAウイルスの細胞侵入と抗体による中和の研究 マイナス鎖RNAウイルスの細胞侵入と抗体による中和の研究 ウイルス ウイルス 2017/06 Disclose to all
久保田万理恵, 橋口隆生, 柳雄介 久保田万理恵, 橋口隆生, 柳雄介 ウイルスの増殖・病態発現機構に関する最新の知見 ムンプスウイルスの糖鎖受容体—ムンプスウイルスのHN蛋白質と糖鎖との相互作用解析 ウイルスの増殖・病態発現機構に関する最新の知見 ムンプスウイルスの糖鎖受容体—ムンプスウイルスのHN蛋白質と糖鎖との相互作用解析 医学のあゆみ 医学のあゆみ 2017/02 Disclose to all
橋口隆生 橋口隆生 感染症研究のいま~メカニズムから予防・治療まで III.予防・治療に向けた研究 10.抗体医薬研究の最前線と展望 感染症研究のいま~メカニズムから予防・治療まで III.予防・治療に向けた研究 10.抗体医薬研究の最前線と展望 実験医学 実験医学 2015/11 Disclose to all
橋口隆生, Erica Ollman Saphire 橋口隆生, Erica Ollman Saphire 交差反応性を示すヒトの抗体によるマールブルグウイルスの中和の分子機構 交差反応性を示すヒトの抗体によるマールブルグウイルスの中和の分子機構 ライフサイエンス新着論文レビュー ライフサイエンス新着論文レビュー 2015/03 Disclose to all
前仲勝実, 橋口隆生, 柳雄介 前仲勝実, 橋口隆生, 柳雄介 抗ウイルス薬 IV.特論 麻疹ウイルスと受容体との複合体の立体構造と今後の展望 抗ウイルス薬 IV.特論 麻疹ウイルスと受容体との複合体の立体構造と今後の展望 日本臨床 日本臨床 2012/04 Disclose to all
橋口隆生, 前仲勝実, 柳雄介 橋口隆生, 前仲勝実, 柳雄介 受容体SLAMと結合した麻疹ウイルスHタンパク質の構造 受容体SLAMと結合した麻疹ウイルスHタンパク質の構造 ライフサイエンス新着論文レビュー ライフサイエンス新着論文レビュー 2011/02 Disclose to all
橋口隆生, 柳雄介 橋口隆生, 柳雄介 麻疹ウイルス受容体結合タンパク質のX線結晶構造解析 麻疹ウイルス受容体結合タンパク質のX線結晶構造解析 感染、炎症、免疫 感染、炎症、免疫 2009/04 Disclose to all
柳雄介, 竹田誠, 橋口隆生 柳雄介, 竹田誠, 橋口隆生 麻疹ウイルス研究の最近の進歩 麻疹ウイルス研究の最近の進歩 小児感染免疫 小児感染免疫 2008/12 Disclose to all
竹田誠, 橋口隆生, 柳雄介 竹田誠, 橋口隆生, 柳雄介 麻疹ウイルスの受容体と病態 麻疹ウイルスの受容体と病態 実験医学 実験医学 2008/11 Disclose to all
橋口隆生, 梶川瑞穂, 竹田誠, 柳雄介, 前仲勝実 橋口隆生, 梶川瑞穂, 竹田誠, 柳雄介, 前仲勝実 ヒト培養細胞を用いた組換え蛋白質の発現 -293系統細胞によるスタンダードプロトコール- ヒト培養細胞を用いた組換え蛋白質の発現 -293系統細胞によるスタンダードプロトコール- 蛋白質科学プロトコール 蛋白質科学会 Webアーカイブ 蛋白質科学プロトコール 蛋白質科学会 Webアーカイブ 2008/06 Disclose to all
橋口隆生, 前仲勝実, 柳雄介 橋口隆生, 前仲勝実, 柳雄介 麻疹ウイルスHタンパク質のX線結晶構造 麻疹ウイルスHタンパク質のX線結晶構造 ウイルス ウイルス 2008/06 Disclose to all
橋口隆生, 柳雄介, 前仲勝実 橋口隆生, 柳雄介, 前仲勝実 結晶構造が解き明かす麻疹ウイルスワクチン成功の理由 結晶構造が解き明かす麻疹ウイルスワクチン成功の理由 Medical Bio Medical Bio 2008/01 Disclose to all

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Title language:
Awards
Title(Japanese) Title(English) Organization name(Japanese) Organization name(English) Date
第1回 日本医療研究開発大賞 AMED理事長賞 内閣官房 健康・医療戦略室 2017/12/13
日本ウイルス学会 杉浦奨励賞 日本ウイルス学会 2016/10/24
文部科学大臣表彰 若手科学者賞 文部科学省 2016/42/0
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
基盤研究(B) Representative 膜融合異常によるパラミクソウイルスの新規感染動態の機構解明とその制御 (2020年度分) 2020/04/01-2021/03/31
挑戦的研究(開拓) Representative 情報科学的アプローチを活用した精密な機能性分子設計システムの構築 (2020年度分) 2020/04/01-2021/03/31
学術変革領域研究(B) Representative ウイルスのPLAMP生成機構とPLAMPを介した病原性制御機構の解明 (2020年度分) 2020/04/01-2021/03/31
Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
創薬生命科学概論 Introduction to Modern Life Sciences for Drug Discovery 前期不定 薬学研究科 2021/04-2022/03
感染防御学I【H30以降入学者用】 Infection and Host Defense I 前期 薬学部 2021/04-2022/03
感染防御学II【H30以降入学者用】 Infection and Host Defense II 後期 薬学部 2021/04-2022/03
感染防御学1 Infection and Host Defense 1 前期 薬学部 2021/04-2022/03
感染防御学2 Infection and Host Defense 2 後期 薬学部 2021/04-2022/03
Faculty management (title, position)
Title Period
ウイルス感染症・生命科学先端融合的共同研究拠点運営委員会 2021/04/01-
ウイルス感染症・生命科学先端融合的共同研究拠点専門委員会 2021/04/01-