内田 洋一朗

Last Update: 2021/06/27 09:30:13

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Name(Kanji/Kana/Abecedarium Latinum)
内田 洋一朗/ウチダ ヨウイチロウ/Uchida, Yoichiro
Primary Affiliation(Org1/Job title)
Kyoto University Hospital Kyoto University Hospital/Assistant Professor
Academic Organizations You are Affiliated to in Japan
Organization name(Japanese) Organization name(English)
⽇本外科学会 Japan Surgical Society
⽇本消化器外科学会 Japanese Society of Gastroenterological Surgery
⽇本肝胆膵外科学会 Japanese Society of Hepato-Biliary-Pancreatic Surgery General incorporated association (JSHBPS)
⽇本移植学会 The Japan Society for Transplantation
⽇本内視鏡外科学会 Japan Society for Endoscopic Surgery
⽇本肝臓学会 Japan Society of Hepatology
⽇本膵臓学会 Japan Pancreas Society
⽇本消化器病学会 The Japanese Society of Gastroenterology
日本臨床外科学会 Japan Surgical Association
日本胆道学会 Japan Biliary Association
日本臨床栄養代謝学会 Japanese Society for Clinical Nutrition and Metabolism
日本外科代謝栄養学会 Japanese Society for Surgical Metabolism and Nutrition
日本外科系連合学会 Japanese College of Surgeons
日本医師会 Japan Medical Association

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Academic Organizations Overaseas You are Affiliated to
Organization name Country
American College of Surgeons USA
American Society of Transplantation USA
Japanese German Society for Study of Liver Surgery (JGSSLS) Japan & Germany
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
博士(医学) Ph.D. 関西医科大学 Kansai Medical University
Academic Resume (Graduate Schools)
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(Japanese) Major(English) Completion Status
関西医科大学 Kansai Medical University 大学院医学研究科博士課程医科学専攻 Surgery 修了
Academic Resume (Undergraduate School/Majors)
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(s)(Japanese) Major(s)(English) Completion Status
関西医科大学 Kansai Medical University 医学部医学科 卒業
High School
Highschool Kana
大阪府立茨木高等学校 おおさかふりついばらきこうとうがっこう
Work Experience
Period Organization(Japanese) Organization(English) Job title(Japanese) Job title(English)
2019/10/01- 京都大学 肝胆膵・移植外科/臓器移植医療部 Kyoto University, Hepato-Biliary-Pancreatic Surgery and Transplantation/Organ Transplant Surgery 助教 Assistant professor
2012/04/01-2019/09/30 (公財)田附興風会医学研究所 北野病院 The Tazuke Kofukai Medical Research Institute, Kitano Hospital, Dept. of Gastroenterological Surgery and Oncology 副部長 Vice-Director
2010/07/16-2012/03/31 京都大学 肝胆膵・移植外科 Kyoto University, Hepato-Biliary-Pancreatic Surgery and Transplantation 医員 Surgical staff
2007/06/01-2010/07/15 カリフォルニア大学ロサンゼルス校 UCLA (University of California, Los Angeles), Dumont-UCLA Transplant Center, Dept. of Surgery 博士研究員 Postdoctoral scholar
Personal Profile
(Japanese)
臨床においては、肝胆膵・移植外科分野を専門(肝胆膵高度技能専門医資格取得)とし、基礎研究では15年以上にわたり一貫として「肝虚血再灌流障害の克服」をメインテーマとして取り組んでいます。
(English)
I am a surgeon of specialty in the field of Hepato-billiary and Pancreas (HBP) and Transplantation. Besides my clinical work, I have been over last 15 years strongly interested in the pathology, molecular mechanism and prevention/treatment of liver injury caused by ischemia and reperfusion insult (IRI), which is one of the major problems in cases of liver resection and liver transplantation. My first and present interest was to contribute liver transplantation and I have had a lot of experiences at the University hospital. Especially, I have experienced well in arterial anastomosis in liver transplantation (Uchida Y. et al. The impact of meticulous management for hepatic artery thrombosis on long-term outcome after pediatric living donor liver transplantation. Clin Transplant. 23:392-399, 2009). I also studied in the Department of Surgery at The Dumont-UCLA Transplant Center, CA, US, as a postdoctoral scholar under Professor Jerzy W. Kupiec-Weglinski from 2007 to 2010. Recently, I also engaged in the surgery of not only liver but also bile duct and pancreas including laparoscopic surgery of liver and pancreas as well as gastro-enteric organs at Dept. of Gastroenterological Surgery and Oncology, The Tazuke Kofukai Medical Research Institute, Kitano Hospital. At present, I am working at Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University Graduate School of Medicine.
Language of Instruction
Language(japanese) Language(english) Code
日本語 Japanese jpn
英語 English eng
Personal Website(s) (URL(s))
URL
https://www.kitano-hp.or.jp/kenkyu/research_activity#05
researchmap URL
https://researchmap.jp/surgeon-uchida
Research Topics
(Japanese)
虚血再灌流障害の克服
(English)
Overcoming Ischemia and Reperfusion Injury
Overview of the research
(Japanese)
肝切除・肝移植など肝臓外科における治療成績向上を目的とし、肝虚血再灌流障害に起因する生体制御システムにおける免疫関連細胞間の相互作用の観点から、①免疫炎症反応(checkpoint分子:Tcell Immunoglobulin and mucin domain-3(TIM-3)/Galectin-9)②薬剤(TLR-4/HMGB-1:トロンボモジュリンおよび分画製剤)③漢方薬④抗酸化物質(VitaminC/E、Polyphenol)⑤食物繊維などの有効性につき、田附興風会医学研究所(北野病院)と連携大学院システムを構築し研究を推進している。さらに⑤短時間食事制限“fasting”という極めてsimpleかつ有効な予防/抑制法を発見し(PNAS,2019)、内因性分子機構(腸内細菌叢、産生有機酸、網羅的遺伝子発現)の解明による”外科周術期の最適な食事療法”と前処置の創出による技術シーズと、肝障害を軽減する薬物(分子)シーズの探索と確立を目指している。
(English)
In the field of liver transplantation, ischemia and reperfusion injury (IRI) causes approximately 10% of early graft failure and leads to a higher incidence of acute and chronic rejection. It is also an urgent issue to overcome IRI from the viewpoint of organ preservation. In terms of the reduction of liver damages caused by IR and to offer the effective method to overcome the liver IRI for the achievement of a safer liver surgery, I have studied the efficacy of various biological molecules (neutrophil elastase inhibitor, recombinant Galectin-9, recombinant thrombomodulin/domain of thrombomodulin and so on), antioxidant agents (vitamins C and E) and maneuvers (preoperative short-term fasting). Among various methods I have examined, the nutritional approach in addition to anti-inflammatory drugs may play as an important role to overcome liver IRI.
Fields of research (key words)
Key words(Japanese) Key words(English)
肝虚血再灌流障害 liver ischemia and reperfusion injury
肝移植 Liver Transplantation
栄養 Nutrition
Awards
Title(Japanese) Title(English) Organization name(Japanese) Organization name(English) Date
Rising Star賞 Rising Star Award 国際肝移植学会 International Liver Transplantation Society 2009/07/09
日本移植学会賞 Congress Award 日本移植学会 The Japan Society for Transplantation 2011/10/05
若手研究者賞 Young Investigator Award 国際肝移植学会 International Liver Transplantation Society 2012/05/16
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
基盤研究(B) Representative 肝臓外科領域における食事療法の有効性および腸内環境の変動解析 (2020年度分) 2020/04/01-2021/03/31
Other research activities
Title Location Misc Period
北野カデットメンター 公益財団法人田附興風会医学研究所北野病院 研究指導 2019/10/01-
Academic organizations (administrative history with title(s), position(s), etc.)
Organization name(Japanese) Organization name(English) Title(Japanese) Title(English) Period
日本肝胆膵外科学会 Japanese Society of Hepato-Biliary-Pancreatic Surgery General incorporated association 肝胆膵高度技能専門医 Board Certified Expert Surgeon (Hepatobiliary-Pancreatic field) 2017/06/01-
アメリカ外科学会 American College of Surgeons アメリカ外科学会専門医 Fellow of American College of Surgeons 2014/10/15-
日本肝胆膵外科学会 Japanese Society of Hepato-Biliary-Pancreatic Surgery General incorporated association 評議員 Councillor 2013/06/13-
日本肝臓学会 Japan Society of Hepatology 肝臓専門医 Board Certified Hepatologist of the Japan Society of Hepatology 2013/04/01-
Other activities (other)
Activity Misc Period
官民協働海外留学支援制度~トビタテ!留学JAPAN 日本代表プログラム~(文部科学省事業) YGL(ヤンググローバルリーダー)としての参画 2016/09/-
Experience of living abroad
Organization Department Research theme Country Period
UCLA (University of California, Los Angeles) Dumont-UCLA Transplant Center, Dept. of Surgery Liver ischemia and reperfusion injury USA 2007/06/01-2010/07/15