蜷川 暁

Last Update: 2019/07/11 17:15:01

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Name(Kanji/Kana/Abecedarium Latinum)
蜷川 暁/ニナガワ サトシ/Ninagawa, Satoshi
Primary Affiliation(Org1/Job title)
Graduate School of Science/Program-Specific Assistant Professor
E-mail Address
E-mail address
sninagawa @ upr.biophys.kyoto-u.ac.jp
Academic Organizations You are Affiliated to in Japan
Organization name(Japanese) Organization name(English)
日本糖質学会 The Japanese Society of Carbohydrate Research
日本生化学会 The Japanese Biochemical Society
日本分子生物学会 The Molecular Biology Society of Japan
日本細胞生物学会 Japan Society for Cell Biology
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(理学) 京都大学
博士(理学) 京都大学
researchmap URL
https://researchmap.jp/sninagawa
Research Topics
(Japanese)
小胞体関連分解機構の解析
(English)
Analysis of ER associated degradation
Overview of the research
(Japanese)
小胞体におけるタンパク質品質管理機構において、構造異常タンパク質を分解するという重要な役割を果たす、小胞体関連分解機構の解析を高等動物細胞を用いて行なっている。
Fields of research (key words)
Key words(Japanese) Key words(English)
小胞体関連分解 ER associated degradation
N型糖鎖 N-glycan
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Ninagawa, S. and Mori, K Ninagawa, S. and Mori, K Ninagawa, S. and Mori, K PNGase Sensitivity Assay to Study the Folding Status of Proteins. PNGase Sensitivity Assay to Study the Folding Status of Proteins. PNGase Sensitivity Assay to Study the Folding Status of Proteins. Bio-protocol, 6, 19, e1952 Bio-protocol, 6, 19, e1952 Bio-protocol, 6, 19, e1952 2016 Refereed Disclose to all
Ninagawa, S. and Mori, K. Ninagawa, S. and Mori, K. Ninagawa, S. and Mori, K. Trypsin Sensitivity Assay to Study the Folding Status of Proteins. Trypsin Sensitivity Assay to Study the Folding Status of Proteins. Trypsin Sensitivity Assay to Study the Folding Status of Proteins. Bio-protocol, 6, 19, e1953 Bio-protocol, 6, 19, e1953 Bio-protocol, 6, 19, e1953 2016 Refereed Disclose to all
岡田 徹也、蜷川 暁、森 和俊 岡田 徹也、蜷川 暁、森 和俊 岡田 徹也、蜷川 暁、森 和俊 みにれびゅう 糖タンパク質の小胞体関連分解におけるマンノーストリミング機構 みにれびゅう 糖タンパク質の小胞体関連分解におけるマンノーストリミング機構 みにれびゅう 糖タンパク質の小胞体関連分解におけるマンノーストリミング機構 生化学, 88, 2, 257-260 生化学, 88, 2, 257-260 生化学, 88, 2, 257-260 2016 Refereed Japanese Disclose to all
蜷川 暁、加藤 晃一、森 和俊 蜷川 暁、加藤 晃一、森 和俊 蜷川 暁、加藤 晃一、森 和俊 糖鎖依存的構造異常タンパク質分解に必須な糖鎖刈り込み機構を解明 糖鎖依存的構造異常タンパク質分解に必須な糖鎖刈り込み機構を解明 糖鎖依存的構造異常タンパク質分解に必須な糖鎖刈り込み機構を解明 化学と生物, 53, 9, 571-573 化学と生物, 53, 9, 571-573 化学と生物, 53, 9, 571-573 2015 Refereed Disclose to all
Ninagawa S, Okada T, Sumitomo Y, Kamiya Y, Kato K, Horimoto S, Ishikawa T, Takeda S, Sakuma T, Yamamoto T, Mori K. Ninagawa S, Okada T, Sumitomo Y, Kamiya Y, Kato K, Horimoto S, Ishikawa T, Takeda S, Sakuma T, Yamamoto T, Mori K. EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step. EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step. EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step. Journal of Cell biology, 206, 3, 347-356 Journal of Cell biology, 206, 3, 347-356 Journal of Cell biology, 206, 3, 347-356 2014 Refereed Disclose to all
Horimoto S*, Ninagawa S*, Okada T, Koba H, Sugimoto T, Kamiya Y, Kato K, Takeda S, Mori K. Horimoto S*, Ninagawa S*, Okada T, Koba H, Sugimoto T, Kamiya Y, Kato K, Takeda S, Mori K. Horimoto S*, Ninagawa S*, Okada T, Koba H, Sugimoto T, Kamiya Y, Kato K, Takeda S, Mori K. The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L. The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L. The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L. Journal of Biological Chemistry, 288, 31517-31527 Journal of Biological Chemistry, 288, 31517-31527 Journal of Biological Chemistry, 288, 31517-31527 2013 Refereed Disclose to all
Ninagawa S, Okada T, Takeda S, Mori K. Ninagawa S, Okada T, Takeda S, Mori K. Ninagawa S, Okada T, Takeda S, Mori K. SEL1L Is Required for Endoplasmic Reticulum-associated Degradation of Misfolded Luminal Proteins but not Transmembrane Proteins in Chicken DT40 Cell Line. SEL1L Is Required for Endoplasmic Reticulum-associated Degradation of Misfolded Luminal Proteins but not Transmembrane Proteins in Chicken DT40 Cell Line. SEL1L Is Required for Endoplasmic Reticulum-associated Degradation of Misfolded Luminal Proteins but not Transmembrane Proteins in Chicken DT40 Cell Line. Cell Structure and Function, 36, 187-195 Cell Structure and Function, 36, 187-195 Cell Structure and Function, 36, 187-195 2011 Refereed Disclose to all
Title language:
Awards
Title(Japanese) Title(English) Organization name(Japanese) Organization name(English) Date
ポスター賞 The 3rd International Sympsium of the Biodiversity and Evolution Global COE project 2009/07/25
若手優秀発表賞 日本細胞生物学会 2016/06/15
CSF論文賞 日本細胞生物学会 2018/06/06
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
基盤研究(C) Representative 小胞体における構造異常タンパク質の分解への基質運搬機構の解明 (平成30年度分) 2018/04/01-2019/03/31
若手研究(B) Representative 小胞体における不安定糖タンパク質と構造異常糖タンパク質の分解メカニズムの解析 Insight into how severely misfiled proteins are degraded in the ER 2016/04/01-2018/03/31
若手研究(B) Representative TALEN法による多重遺伝子破壊株を用いたヒト小胞体関連分解因子の網羅的解析 Analysis of ER-associated degradation components by multiple knockout cell lines using TALEN 2014/04/01-2016/03/31
External funds: other than those above
System Main person Title(Japanese) Title(English) Period
群馬大学生体調節研究所内分泌・代謝学共同研究拠点共同研究 蜷川 暁 第二世代抗精神病薬オランザピンがインスリン分泌へ与える効果の解析 2018/04/01-2019/03/31