髙橋 重成

Last Update: 2021/05/19 11:42:07

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Name(Kanji/Kana/Abecedarium Latinum)
髙橋 重成/タカハシ ノブアキ/Takahashi, Nobuaki
Primary Affiliation(Org1/Job title)
The HAKUBI Center for Advanced Research/Program-Specific Associate Professor
Contact Address
Type Address(Japanese) Address(English)
Office 京都市西京区京都大学桂キャンパスA4棟219号室
Phone
Type Number
Office 075-383-2763
E-mail Address
E-mail address
takahashi @ sbchem.kyoto-u.ac.jp
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(工学) 京都大学
博士(工学) 京都大学
Academic Resume (Graduate Schools)
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(Japanese) Major(English) Completion Status
京都大学 大学院工学研究科修士課程合成・生物化学専攻 修了
京都大学 大学院工学研究科博士後期課程合成・生物化学専攻 修了
Academic Resume (Undergraduate School/Majors)
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(s)(Japanese) Major(s)(English) Completion Status
京都大学 工学部工業化学科 卒業
High School
Highschool Kana
立教新座高等学校 りっきょうにいざこうとうがっこう
Work Experience
Period Organization(Japanese) Organization(English) Job title(Japanese) Job title(English)
2010/12/01-2014/05/31 京都大学 先端医工学研究ユニット 特定助教
2014/06/01-2015/05/31 ハーバード大学医学大学院 細胞生物学分野 博士研究員
2015/06/01-2019/03/31 ハーバード大学医学大学院 細胞生物学分野 専任講師
Personal Website(s) (URL(s))
URL
https://www.hakubi.kyoto-u.takahashi-group.net
researchmap URL
https://researchmap.jp/0404
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Akito Nakao, Yoshihiro Matsunaga, Katsumi Hayashida, Nobuaki Takahashi* Akito Nakao, Yoshihiro Matsunaga, Katsumi Hayashida, Nobuaki Takahashi* Akito Nakao, Yoshihiro Matsunaga, Katsumi Hayashida, Nobuaki Takahashi* Role of Oxidative Stress and Ca2+ Signaling in Psychiatric Disorders Role of Oxidative Stress and Ca2+ Signaling in Psychiatric Disorders Role of Oxidative Stress and Ca2+ Signaling in Psychiatric Disorders Front. Cell Dev. Biol., 9 Front. Cell Dev. Biol., 9 Front. Cell Dev. Biol., 9 2021/02 Refereed Disclose to all
Nobuaki Takahashi (Shared Corresponding Author), Patricia Cho, Laura M Selfors, Hendrik J Kuiken, Roma Kaul, Takuro Fujiwara, Isaac S Harris, Tian Zhang, Steven P Gygi, Joan S Brugge Nobuaki Takahashi (Shared Corresponding Author), Patricia Cho, Laura M Selfors, Hendrik J Kuiken, Roma Kaul, Takuro Fujiwara, Isaac S Harris, Tian Zhang, Steven P Gygi, Joan S Brugge Nobuaki Takahashi (Shared Corresponding Author), Patricia Cho, Laura M Selfors, Hendrik J Kuiken, Roma Kaul, Takuro Fujiwara, Isaac S Harris, Tian Zhang, Steven P Gygi, Joan S Brugge 3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis. 3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis. 3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis. Molecular cell Molecular cell Molecular cell 2020/10/26 Refereed English Research paper(scientific journal) Disclose to all
Sichong Chen, Nobuaki Takahashi (Co-first), Changping Chen, Jordan L. Pauli, Chiharu Kuroki, Jun Kaminosono, Hideki Kashiwadani, Yuichi Kanmura, Yasuo Mori, Shaowu Ou, Liying Hao, Tomoyuki Kuwaki Sichong Chen, Nobuaki Takahashi (Co-first), Changping Chen, Jordan L. Pauli, Chiharu Kuroki, Jun Kaminosono, Hideki Kashiwadani, Yuichi Kanmura, Yasuo Mori, Shaowu Ou, Liying Hao, Tomoyuki Kuwaki Sichong Chen, Nobuaki Takahashi (Co-first), Changping Chen, Jordan L. Pauli, Chiharu Kuroki, Jun Kaminosono, Hideki Kashiwadani, Yuichi Kanmura, Yasuo Mori, Shaowu Ou, Liying Hao, Tomoyuki Kuwaki Transient Receptor Potential Ankyrin 1 Mediates Hypoxic Responses in Mice Transient Receptor Potential Ankyrin 1 Mediates Hypoxic Responses in Mice Transient Receptor Potential Ankyrin 1 Mediates Hypoxic Responses in Mice Frontiers in Physiology, 11 Frontiers in Physiology, 11 Frontiers in Physiology, 11 2020/10/22 Refereed Research paper(scientific journal) Disclose to all
Makoto Uchiyama, Akito Nakao, Yuki Kurita, Isato Fukushi, Kotaro Takeda, Tomohiro Numata, Ha Nam Tran, Seishiro Sawamura, Maximilian Ebert, Tatsuki Kurokawa, Reiko Sakaguchi, Alexander J Stokes, Nobuaki Takahashi, Yasumasa Okada, Yasuo Mori Makoto Uchiyama, Akito Nakao, Yuki Kurita, Isato Fukushi, Kotaro Takeda, Tomohiro Numata, Ha Nam Tran, Seishiro Sawamura, Maximilian Ebert, Tatsuki Kurokawa, Reiko Sakaguchi, Alexander J Stokes, Nobuaki Takahashi, Yasumasa Okada, Yasuo Mori Makoto Uchiyama, Akito Nakao, Yuki Kurita, Isato Fukushi, Kotaro Takeda, Tomohiro Numata, Ha Nam Tran, Seishiro Sawamura, Maximilian Ebert, Tatsuki Kurokawa, Reiko Sakaguchi, Alexander J Stokes, Nobuaki Takahashi, Yasumasa Okada, Yasuo Mori O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses. O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses. O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses. Current biology : CB, 30, 17, 3378-3396 Current biology : CB, 30, 17, 3378-3396 Current biology : CB, 30, 17, 3378-3396 2020/09/07 Refereed English Research paper(scientific journal) Disclose to all
Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell metabolism, 29, 5, 1166-1181 Cell metabolism, 29, 5, 1166-1181 Cell metabolism, 29, 5, 1166-1181 2019/05 Refereed Disclose to all
Nobuaki Takahashi, Hsing-Yu Chen, Isaac S. Harris, Daniel G. Stover, Laura M. Selfors, Roderick T. Bronson, Thomas Deraedt, Karen Cichowski, Alana L. Welm, Yasuo Mori, Gordon B. Mills, Joan S. Brugge Nobuaki Takahashi, Hsing-Yu Chen, Isaac S. Harris, Daniel G. Stover, Laura M. Selfors, Roderick T. Bronson, Thomas Deraedt, Karen Cichowski, Alana L. Welm, Yasuo Mori, Gordon B. Mills, Joan S. Brugge Nobuaki Takahashi, Hsing-Yu Chen, Isaac S. Harris, Daniel G. Stover, Laura M. Selfors, Roderick T. Bronson, Thomas Deraedt, Karen Cichowski, Alana L. Welm, Yasuo Mori, Gordon B. Mills, Joan S. Brugge Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance Cancer Cell, 33, 6, 985-1003.e7 Cancer Cell, 33, 6, 985-1003.e7 Cancer Cell, 33, 6, 985-1003.e7 2018/06/11 Refereed English Research paper(scientific journal) Disclose to all
Takahito Miyake, Saki Nakamura, Zhao Meng, Satoshi Hamano, Keisuke Inoue, Tomohiro Numata, Nobuaki Takahashi, Kazuki Nagayasu, Hisashi Shirakawa, Yasuo Mori, Takayuki Nakagawa, Shuji Kaneko Takahito Miyake, Saki Nakamura, Zhao Meng, Satoshi Hamano, Keisuke Inoue, Tomohiro Numata, Nobuaki Takahashi, Kazuki Nagayasu, Hisashi Shirakawa, Yasuo Mori, Takayuki Nakagawa, Shuji Kaneko Takahito Miyake, Saki Nakamura, Zhao Meng, Satoshi Hamano, Keisuke Inoue, Tomohiro Numata, Nobuaki Takahashi, Kazuki Nagayasu, Hisashi Shirakawa, Yasuo Mori, Takayuki Nakagawa, Shuji Kaneko Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin FRONTIERS IN PHYSIOLOGY, 8, 878 FRONTIERS IN PHYSIOLOGY, 8, 878 FRONTIERS IN PHYSIOLOGY, 8, 878 2017/11 Refereed English Research paper(scientific journal) Disclose to all
Yasuo Mori, Nobuaki Takahashi, Tatsuki Kurokawa, Shigeki Kiyonaka Yasuo Mori, Nobuaki Takahashi, Tatsuki Kurokawa, Shigeki Kiyonaka Yasuo Mori, Nobuaki Takahashi, Tatsuki Kurokawa, Shigeki Kiyonaka TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in O-2 sensing TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in O-2 sensing TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in O-2 sensing PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 93, 7, 464-482 PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 93, 7, 464-482 PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 93, 7, 464-482 2017/07 Refereed English Disclose to all
Takahito Miyake, Saki Nakamura, Meng Zhao, Kanako So, Keisuke Inoue, Tomohiro Numata, Nobuaki Takahashi, Hisashi Shirakawa, Yasuo Mori, Takayuki Nakagawa, Shuji Kaneko Takahito Miyake, Saki Nakamura, Meng Zhao, Kanako So, Keisuke Inoue, Tomohiro Numata, Nobuaki Takahashi, Hisashi Shirakawa, Yasuo Mori, Takayuki Nakagawa, Shuji Kaneko Takahito Miyake, Saki Nakamura, Meng Zhao, Kanako So, Keisuke Inoue, Tomohiro Numata, Nobuaki Takahashi, Hisashi Shirakawa, Yasuo Mori, Takayuki Nakagawa, Shuji Kaneko Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS NATURE COMMUNICATIONS, 7, 12840 NATURE COMMUNICATIONS, 7, 12840 NATURE COMMUNICATIONS, 7, 12840 2016/09 Refereed English Research paper(scientific journal) Disclose to all
Nozomi Ogawa, Tatsuki Kurokawa, Kenji Fujiwara, Onur Kerem Polat, Heba Badr, Nobuaki Takahashi, Yasuo Mori Nozomi Ogawa, Tatsuki Kurokawa, Kenji Fujiwara, Onur Kerem Polat, Heba Badr, Nobuaki Takahashi, Yasuo Mori Nozomi Ogawa, Tatsuki Kurokawa, Kenji Fujiwara, Onur Kerem Polat, Heba Badr, Nobuaki Takahashi, Yasuo Mori Functional and Structural Divergence in Human TRPV1 Channel Subunits by Oxidative Cysteine Modification Functional and Structural Divergence in Human TRPV1 Channel Subunits by Oxidative Cysteine Modification Functional and Structural Divergence in Human TRPV1 Channel Subunits by Oxidative Cysteine Modification JOURNAL OF BIOLOGICAL CHEMISTRY, 291, 8, 4197-4210 JOURNAL OF BIOLOGICAL CHEMISTRY, 291, 8, 4197-4210 JOURNAL OF BIOLOGICAL CHEMISTRY, 291, 8, 4197-4210 2016/02 Refereed English Research paper(scientific journal) Disclose to all
Takahiro Shibata, Katsuhiro Takahashi, Yui Matsubara, Emi Inuzuka, Fumie Nakashima, Nobuaki Takahashi, Daisuke Kozai, Yasuo Mori, Koji Uchida Takahiro Shibata, Katsuhiro Takahashi, Yui Matsubara, Emi Inuzuka, Fumie Nakashima, Nobuaki Takahashi, Daisuke Kozai, Yasuo Mori, Koji Uchida Takahiro Shibata, Katsuhiro Takahashi, Yui Matsubara, Emi Inuzuka, Fumie Nakashima, Nobuaki Takahashi, Daisuke Kozai, Yasuo Mori, Koji Uchida Identification of a prostaglandin D-2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel Identification of a prostaglandin D-2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel Identification of a prostaglandin D-2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel SCIENTIFIC REPORTS, 6, 21261 SCIENTIFIC REPORTS, 6, 21261 SCIENTIFIC REPORTS, 6, 21261 2016/02 Refereed English Research paper(scientific journal) Disclose to all
Yasuo Mori, Nobuaki Takahashi, Onur Kerem Polat, Tatsuki Kurokawa, Norihiko Takeda, Masahiro Inoue Yasuo Mori, Nobuaki Takahashi, Onur Kerem Polat, Tatsuki Kurokawa, Norihiko Takeda, Masahiro Inoue Yasuo Mori, Nobuaki Takahashi, Onur Kerem Polat, Tatsuki Kurokawa, Norihiko Takeda, Masahiro Inoue Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 468, 1, 85-97 PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 468, 1, 85-97 PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 468, 1, 85-97 2016/01 Refereed English Disclose to all
Yasuo Mori, Nobuaki Takahashi, Nozomi Ogawa, Thomas Gudermann Yasuo Mori, Nobuaki Takahashi, Nozomi Ogawa, Thomas Gudermann Yasuo Mori, Nobuaki Takahashi, Nozomi Ogawa, Thomas Gudermann Oxygen physiology: sensors and ion channels Oxygen physiology: sensors and ion channels Oxygen physiology: sensors and ion channels PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 468, 1, 1-2 PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 468, 1, 1-2 PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 468, 1, 1-2 2016/01 English Disclose to all
Shunichi Shimizu, Ryo Yonezawa, Tamio Hagiwara, Takashi Yoshida, Nobuaki Takahashi, Satoshi Hamano, Takaharu Negoro, Takahiro Toda, Minoru Wakamori, Yasuo Mori, Masakazu Ishii Shunichi Shimizu, Ryo Yonezawa, Tamio Hagiwara, Takashi Yoshida, Nobuaki Takahashi, Satoshi Hamano, Takaharu Negoro, Takahiro Toda, Minoru Wakamori, Yasuo Mori, Masakazu Ishii Shunichi Shimizu, Ryo Yonezawa, Tamio Hagiwara, Takashi Yoshida, Nobuaki Takahashi, Satoshi Hamano, Takaharu Negoro, Takahiro Toda, Minoru Wakamori, Yasuo Mori, Masakazu Ishii Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry EUROPEAN JOURNAL OF PHARMACOLOGY, 742, 22-30 EUROPEAN JOURNAL OF PHARMACOLOGY, 742, 22-30 EUROPEAN JOURNAL OF PHARMACOLOGY, 742, 22-30 2014/11 Refereed English Research paper(scientific journal) Disclose to all
Nobuaki Takahashi, Sayaka Hamada-Nakahara, Yuzuru Itoh, Kazuhiro Takemura, Atsushi Shimada, Yoshifumi Ueda, Manabu Kitamata, Rei Matsuoka, Kyoko Hanawa-Suetsugu, Yosuke Senju, Masayuki X. Mori, Shigeki Kiyonaka, Daisuke Kohda, Akio Kitao, Yasuo Mori, Shiro Suetsugu Takahashi N, Hamada-Nakahara S, Itoh Y, Takemura K, Shimada A, Ueda Y, Kitamata M, Matsuoka R, Hanawa-Suetsugu K, Senju Y, Mori MX, Kiyonaka S, Kohda D, Kitao A, Mori Y, Suetsugu S Nobuaki Takahashi, Sayaka Hamada-Nakahara, Yuzuru Itoh, Kazuhiro Takemura, Atsushi Shimada, Yoshifumi Ueda, Manabu Kitamata, Rei Matsuoka, Kyoko Hanawa-Suetsugu, Yosuke Senju, Masayuki X. Mori, Shigeki Kiyonaka, Daisuke Kohda, Akio Kitao, Yasuo Mori, Shiro Suetsugu TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P-2 TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P₂. TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P-2 NATURE COMMUNICATIONS, 5, 4994 Nature communications, 5, 4994 NATURE COMMUNICATIONS, 5, 4994 2014/09 Refereed English Research paper(scientific journal) Disclose to all
N. Takahashi, Y. Mori N. Takahashi, Y. Mori N. Takahashi, Y. Mori The O-2- sensing TRPA1 channel illustrates the significance of vagal nerves in cardio- respiratory adaptation to hypoxia The O-2- sensing TRPA1 channel illustrates the significance of vagal nerves in cardio- respiratory adaptation to hypoxia The O-2- sensing TRPA1 channel illustrates the significance of vagal nerves in cardio- respiratory adaptation to hypoxia ACTA PHYSIOLOGICA, 210, 4, 705-707 ACTA PHYSIOLOGICA, 210, 4, 705-707 ACTA PHYSIOLOGICA, 210, 4, 705-707 2014/04 English Disclose to all
Daisuke Kozai, Yoji Kabasawa, Maximilian Ebert, Shigeki Kiyonaka, Firman Yuko Otani, Tomohiro Numata, Nobuaki Takahashi, Yasuo Mori, Tomohiko Ohwada Daisuke Kozai, Yoji Kabasawa, Maximilian Ebert, Shigeki Kiyonaka, Firman Yuko Otani, Tomohiro Numata, Nobuaki Takahashi, Yasuo Mori, Tomohiko Ohwada Daisuke Kozai, Yoji Kabasawa, Maximilian Ebert, Shigeki Kiyonaka, Firman Yuko Otani, Tomohiro Numata, Nobuaki Takahashi, Yasuo Mori, Tomohiko Ohwada Transnitrosylation Directs TRPA1 Selectivity in N-Nitrosamine Activators Transnitrosylation Directs TRPA1 Selectivity in N-Nitrosamine Activators Transnitrosylation Directs TRPA1 Selectivity in N-Nitrosamine Activators MOLECULAR PHARMACOLOGY, 85, 1, 175-185 MOLECULAR PHARMACOLOGY, 85, 1, 175-185 MOLECULAR PHARMACOLOGY, 85, 1, 175-185 2014/01 Refereed English Research paper(scientific journal) Disclose to all
Shunichi Shimizu, Nobuaki Takahashi, Yasuo Mori Shunichi Shimizu, Nobuaki Takahashi, Yasuo Mori Shunichi Shimizu, Nobuaki Takahashi, Yasuo Mori TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters) TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters) TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters) Handbook of Experimental Pharmacology, 223, 767-794 Handbook of Experimental Pharmacology, 223, 767-794 Handbook of Experimental Pharmacology, 223, 767-794 2014 Refereed English Research paper(scientific journal) Disclose to all
Toru Yonemitsu, Chiharu Kuroki, Nobuaki Takahashi, Yasuo Mori, Yuichi Kanmura, Hideki Kashiwadani, Youichirou Ootsuka, Tomoyuki Kuwaki Toru Yonemitsu, Chiharu Kuroki, Nobuaki Takahashi, Yasuo Mori, Yuichi Kanmura, Hideki Kashiwadani, Youichirou Ootsuka, Tomoyuki Kuwaki Toru Yonemitsu, Chiharu Kuroki, Nobuaki Takahashi, Yasuo Mori, Yuichi Kanmura, Hideki Kashiwadani, Youichirou Ootsuka, Tomoyuki Kuwaki TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep SCIENTIFIC REPORTS, 3, 3100 SCIENTIFIC REPORTS, 3, 3100 SCIENTIFIC REPORTS, 3, 3100 2013/10 Refereed English Research paper(scientific journal) Disclose to all
Tomohiro Numata, Nozomi Ogawa, Nobuaki Takahashi, Yasuo Mori Tomohiro Numata, Nozomi Ogawa, Nobuaki Takahashi, Yasuo Mori Tomohiro Numata, Nozomi Ogawa, Nobuaki Takahashi, Yasuo Mori TRP channels as sensors of oxygen availability TRP channels as sensors of oxygen availability TRP channels as sensors of oxygen availability PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 465, 8, 1075-1085 PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 465, 8, 1075-1085 PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 465, 8, 1075-1085 2013/08 Refereed English Disclose to all
Nobuaki Takahashi, Daisuke Kozai, Yasuo Mori Nobuaki Takahashi, Daisuke Kozai, Yasuo Mori Nobuaki Takahashi, Daisuke Kozai, Yasuo Mori TRP channels: sensors and transducers of gasotransmitter signals TRP channels: sensors and transducers of gasotransmitter signals TRP channels: sensors and transducers of gasotransmitter signals FRONTIERS IN PHYSIOLOGY, 3, 324 FRONTIERS IN PHYSIOLOGY, 3, 324 FRONTIERS IN PHYSIOLOGY, 3, 324 2012 Refereed English Disclose to all
Nobuaki Takahashi, Tomoyuki Kuwaki, Shigeki Kiyonaka, Tomohiro Numata, Daisuke Kozai, Yusuke Mizuno, Shinichiro Yamamoto, Shinji Naito, Ellen Knevels, Peter Carmeliet, Toru Oga, Shuji Kaneko, Seiji Suga, Toshiki Nokami, Jun-ichi Yoshida, Yasuo Mori Nobuaki Takahashi, Tomoyuki Kuwaki, Shigeki Kiyonaka, Tomohiro Numata, Daisuke Kozai, Yusuke Mizuno, Shinichiro Yamamoto, Shinji Naito, Ellen Knevels, Peter Carmeliet, Toru Oga, Shuji Kaneko, Seiji Suga, Toshiki Nokami, Jun-ichi Yoshida, Yasuo Mori Nobuaki Takahashi, Tomoyuki Kuwaki, Shigeki Kiyonaka, Tomohiro Numata, Daisuke Kozai, Yusuke Mizuno, Shinichiro Yamamoto, Shinji Naito, Ellen Knevels, Peter Carmeliet, Toru Oga, Shuji Kaneko, Seiji Suga, Toshiki Nokami, Jun-ichi Yoshida, Yasuo Mori TRPA1 underlies a sensing mechanism for O-2 TRPA1 underlies a sensing mechanism for O-2 TRPA1 underlies a sensing mechanism for O-2 NATURE CHEMICAL BIOLOGY, 7, 10, 701-711 NATURE CHEMICAL BIOLOGY, 7, 10, 701-711 NATURE CHEMICAL BIOLOGY, 7, 10, 701-711 2011/10 Refereed English Research paper(scientific journal) Disclose to all
Nobuaki Takahashi, Daisuke Kozai, Ryohei Kobayashi, Maximilian Ebert, Yasuo Mori Nobuaki Takahashi, Daisuke Kozai, Ryohei Kobayashi, Maximilian Ebert, Yasuo Mori Nobuaki Takahashi, Daisuke Kozai, Ryohei Kobayashi, Maximilian Ebert, Yasuo Mori Roles of TRPM2 in oxidative stress Roles of TRPM2 in oxidative stress Roles of TRPM2 in oxidative stress CELL CALCIUM, 50, 3, 279-287 CELL CALCIUM, 50, 3, 279-287 CELL CALCIUM, 50, 3, 279-287 2011/09 Refereed English Disclose to all
Yasuo Mori, Taketoshi Kajimoto, Akito Nakao, Nobuaki Takahashi, Shigeki Kiyonaka Yasuo Mori, Taketoshi Kajimoto, Akito Nakao, Nobuaki Takahashi, Shigeki Kiyonaka Yasuo Mori, Taketoshi Kajimoto, Akito Nakao, Nobuaki Takahashi, Shigeki Kiyonaka Receptor Signaling Integration by TRP Channelsomes Receptor Signaling Integration by TRP Channelsomes Receptor Signaling Integration by TRP Channelsomes TRANSIENT RECEPTOR POTENTIAL CHANNELS, 704, 373-389 TRANSIENT RECEPTOR POTENTIAL CHANNELS, 704, 373-389 TRANSIENT RECEPTOR POTENTIAL CHANNELS, 704, 373-389 2011 English Research paper(scientific journal) Disclose to all
Nobuaki Takahashi, Yasuo Mori Nobuaki Takahashi, Yasuo Mori Nobuaki Takahashi, Yasuo Mori TRP channels as sensors and signal integrators of redox status changes TRP channels as sensors and signal integrators of redox status changes TRP channels as sensors and signal integrators of redox status changes FRONTIERS IN PHARMACOLOGY, 2, 58 FRONTIERS IN PHARMACOLOGY, 2, 58 FRONTIERS IN PHARMACOLOGY, 2, 58 2011 Refereed English Disclose to all
Numata T, Kiyonaka S, Kato K, Takahashi N, Mori Y, Zhu MX Numata T, Kiyonaka S, Kato K, Takahashi N, Mori Y, Zhu MX Numata T, Kiyonaka S, Kato K, Takahashi N, Mori Y, Zhu MX Activation of TRP Channels in Mammalian Systems Activation of TRP Channels in Mammalian Systems Activation of TRP Channels in Mammalian Systems 2011 Refereed Disclose to all
Shinichiro Yamamoto, Nobuaki Takahashi, Yasuo Mori Shinichiro Yamamoto, Nobuaki Takahashi, Yasuo Mori Shinichiro Yamamoto, Nobuaki Takahashi, Yasuo Mori Chemical physiology of oxidative stress-activated TRPM2 and TRPC5 channels Chemical physiology of oxidative stress-activated TRPM2 and TRPC5 channels Chemical physiology of oxidative stress-activated TRPM2 and TRPC5 channels PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 103, 1, 18-27 PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 103, 1, 18-27 PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 103, 1, 18-27 2010/09 Refereed English Disclose to all
Ivan Bogeski, Carsten Kummerow, Dalia Al-Ansary, Eva C. Schwarz, Richard Koehler, Daisuke Kozai, Nobuaki Takahashi, Christine Peinelt, Desiree Griesemer, Monika Bozem, Yasuo Mori, Markus Hoth, Barbara A. Niemeyer Ivan Bogeski, Carsten Kummerow, Dalia Al-Ansary, Eva C. Schwarz, Richard Koehler, Daisuke Kozai, Nobuaki Takahashi, Christine Peinelt, Desiree Griesemer, Monika Bozem, Yasuo Mori, Markus Hoth, Barbara A. Niemeyer Ivan Bogeski, Carsten Kummerow, Dalia Al-Ansary, Eva C. Schwarz, Richard Koehler, Daisuke Kozai, Nobuaki Takahashi, Christine Peinelt, Desiree Griesemer, Monika Bozem, Yasuo Mori, Markus Hoth, Barbara A. Niemeyer Differential redox regulation of ORAI ion channels: A mechanism to tune cellular Calcium signaling Differential redox regulation of ORAI ion channels: A mechanism to tune cellular Calcium signaling Differential redox regulation of ORAI ion channels: A mechanism to tune cellular Calcium signaling Science Signaling, 3, 115, ra24 Science Signaling, 3, 115, ra24 Science Signaling, 3, 115, ra24 2010/03/30 Refereed English Research paper(scientific journal) Disclose to all
Ivan Bogeski, Carsten Kummerow, Dalia Al-Ansary, Eva C. Schwarz, Richard Koehler, Daisuke Kozai, Nobuaki Takahashi, Christine Peinelt, Desiree Griesemer, Monika Bozem, Yasuo Mori, Markus Hoth, Barbara A. Niemeyer Ivan Bogeski, Carsten Kummerow, Dalia Al-Ansary, Eva C. Schwarz, Richard Koehler, Daisuke Kozai, Nobuaki Takahashi, Christine Peinelt, Desiree Griesemer, Monika Bozem, Yasuo Mori, Markus Hoth, Barbara A. Niemeyer Ivan Bogeski, Carsten Kummerow, Dalia Al-Ansary, Eva C. Schwarz, Richard Koehler, Daisuke Kozai, Nobuaki Takahashi, Christine Peinelt, Desiree Griesemer, Monika Bozem, Yasuo Mori, Markus Hoth, Barbara A. Niemeyer Differential Redox Regulation of ORAI Ion Channels: A Mechanism to Tune Cellular Calcium Signaling Differential Redox Regulation of ORAI Ion Channels: A Mechanism to Tune Cellular Calcium Signaling Differential Redox Regulation of ORAI Ion Channels: A Mechanism to Tune Cellular Calcium Signaling SCIENCE SIGNALING, 3, 115, ra24 SCIENCE SIGNALING, 3, 115, ra24 SCIENCE SIGNALING, 3, 115, ra24 2010/03 Refereed English Research paper(scientific journal) Disclose to all
Shinichiro Yamamoto, Shunichi Shimizu, Shigeki Kiyonaka, Nobuaki Takahashi, Teruaki Wajima, Yuji Hara, Takaharu Negoro, Toshihito Hiroi, Yuji Kiuchi, Takaharu Okada, Shuji Kaneko, Ingo Lange, Andrea Fleig, Reinhold Penner, Miyuki Nishi, Hiroshi Takeshima, Yasuo Mori Shinichiro Yamamoto, Shunichi Shimizu, Shigeki Kiyonaka, Nobuaki Takahashi, Teruaki Wajima, Yuji Hara, Takaharu Negoro, Toshihito Hiroi, Yuji Kiuchi, Takaharu Okada, Shuji Kaneko, Ingo Lange, Andrea Fleig, Reinhold Penner, Miyuki Nishi, Hiroshi Takeshima, Yasuo Mori Shinichiro Yamamoto, Shunichi Shimizu, Shigeki Kiyonaka, Nobuaki Takahashi, Teruaki Wajima, Yuji Hara, Takaharu Negoro, Toshihito Hiroi, Yuji Kiuchi, Takaharu Okada, Shuji Kaneko, Ingo Lange, Andrea Fleig, Reinhold Penner, Miyuki Nishi, Hiroshi Takeshima, Yasuo Mori TRPM2-mediated Ca(2+) influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration TRPM2-mediated Ca(2+) influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration TRPM2-mediated Ca(2+) influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration NATURE MEDICINE, 14, 7, 738-747 NATURE MEDICINE, 14, 7, 738-747 NATURE MEDICINE, 14, 7, 738-747 2008/07 Refereed English Research paper(scientific journal) Disclose to all
Nobuaki Takahashi, Yusuke Mizuno, Daisuke Kozai, Shinichiro Yamamoto, Shigeki Kiyonaka, Takahiro Shibata, Koji Uchida, Yasuo Mori Nobuaki Takahashi, Yusuke Mizuno, Daisuke Kozai, Shinichiro Yamamoto, Shigeki Kiyonaka, Takahiro Shibata, Koji Uchida, Yasuo Mori Nobuaki Takahashi, Yusuke Mizuno, Daisuke Kozai, Shinichiro Yamamoto, Shigeki Kiyonaka, Takahiro Shibata, Koji Uchida, Yasuo Mori Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators CHANNELS, 2, 4, 287-298 CHANNELS, 2, 4, 287-298 CHANNELS, 2, 4, 287-298 2008/07 Refereed English Research paper(scientific journal) Disclose to all
Takashi Yoshida, Ryuji Inoue, Takashi Morii, Nobuaki Takahashi, Shinichiro Yamamoto, Yuji Hara, Makoto Tominaga, Shunichi Shimizu, Yoji Sato, Yasuo Mori Takashi Yoshida, Ryuji Inoue, Takashi Morii, Nobuaki Takahashi, Shinichiro Yamamoto, Yuji Hara, Makoto Tominaga, Shunichi Shimizu, Yoji Sato, Yasuo Mori Takashi Yoshida, Ryuji Inoue, Takashi Morii, Nobuaki Takahashi, Shinichiro Yamamoto, Yuji Hara, Makoto Tominaga, Shunichi Shimizu, Yoji Sato, Yasuo Mori Nitric oxide activates TRP channels by cysteine S-nitrosylation Nitric oxide activates TRP channels by cysteine S-nitrosylation Nitric oxide activates TRP channels by cysteine S-nitrosylation NATURE CHEMICAL BIOLOGY, 2, 11, 596-607 NATURE CHEMICAL BIOLOGY, 2, 11, 596-607 NATURE CHEMICAL BIOLOGY, 2, 11, 596-607 2006/11 Refereed English Research paper(scientific journal) Disclose to all

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Title language:
Books etc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Publisher Publisher(Japanese) Publisher(English) Publication date Language Type Disclose
高橋重成, 森 泰生 高橋重成, 森 泰生 内因性のストレスを積極的に活用するイオンチャネル機構 内因性のストレスを積極的に活用するイオンチャネル機構 実験医学 実験医学 2020/06 Disclose to all
高橋 重成 高橋 重成 新規Ca²⁺チャネルTRPA1はがん細胞の酸化ストレス耐性を担う 新規Ca²⁺チャネルTRPA1はがん細胞の酸化ストレス耐性を担う がん分子標的治療 がん分子標的治療 2019/12 Disclose to all
高橋 重成 高橋 重成 がん細胞はワサビ受容体を発現することで酸化ストレス耐性を亢進させている がん細胞はワサビ受容体を発現することで酸化ストレス耐性を亢進させている 実験医学 実験医学 2018/10 Disclose to all
高橋重成, 森泰生, Joan, S. Brugge 高橋重成, 森泰生, Joan, S. Brugge がん細胞は感覚受容の分子機構をハイジャックすることで酸化ストレス耐性機能を亢進させている がん細胞は感覚受容の分子機構をハイジャックすることで酸化ストレス耐性機能を亢進させている 新着論文レビュー 新着論文レビュー 2018/06 Disclose to all
末次志郎, 高橋重成, 伊藤弓弦, 竹村和浩, 嶋田 睦, 北尾彰朗, 森 泰生 末次志郎, 高橋重成, 伊藤弓弦, 竹村和浩, 嶋田 睦, 北尾彰朗, 森 泰生 TRPV4イオンチャネルのアンキリンリピート ドメインとPI(4,5)P2の相互作用による新たな制御機構 TRPV4イオンチャネルのアンキリンリピート ドメインとPI(4,5)P2の相互作用による新たな制御機構 生物物理 生物物理 2015/07 Disclose to all
植田誉志史, 高橋重成, 森泰生 植田誉志史, 高橋重成, 森泰生 TRPA1チャネルを介した酸素・活性酸素種センシング TRPA1チャネルを介した酸素・活性酸素種センシング 実験医学 実験医学 2012/10 Disclose to all
高橋重成, 植田誉志史, 森泰生 高橋重成, 植田誉志史, 森泰生 TRP チャネルを介する新しい酸素センシング機構 TRP チャネルを介する新しい酸素センシング機構 実験医学 実験医学 2012/05 Disclose to all
高橋 重成 高橋 重成 TRPA1チャネルによる酸素感受性 TRPA1チャネルによる酸素感受性 医学のあゆみ 医学のあゆみ 2012/04 Disclose to all
清中茂樹, 高橋重成, 森泰生 清中茂樹, 高橋重成, 森泰生 活性酸素で活性化されるTRPチャネル 活性酸素で活性化されるTRPチャネル ファルマシア ファルマシア 2012 Disclose to all
植田誉志史, 高橋重成, 森泰生 植田誉志史, 高橋重成, 森泰生 新たな酸素センサー/チャネルによる低酸素応答制御 新たな酸素センサー/チャネルによる低酸素応答制御 血管医学 血管医学 2012 Disclose to all
森泰生, 高橋重成 森泰生, 高橋重成 酸素を検知する生体内ケモセンサーイオンチャネル 酸素を検知する生体内ケモセンサーイオンチャネル 化学マスター講座 一般化学(丸善) 化学マスター講座 一般化学(丸善) 2012 Disclose to all
高橋 重成, 森 泰生 高橋 重成, 森 泰生 TRPA1チャネルが担う生体における新しいO2センサー機構 TRPA1チャネルが担う生体における新しいO2センサー機構 新着論文レビュー 新着論文レビュー 2011/09 Disclose to all
森泰生, 高橋重成 森泰生, 高橋重成 イオンチャネル イオンチャネル トランスポートソームの世界 トランスポートソームの世界 2011 Disclose to all
森泰生, 沼田朋大, 高橋重成 森泰生, 沼田朋大, 高橋重成 生体内センサーとしてのイオンチャネル 総論 生体内センサーとしてのイオンチャネル 総論 トランスポートソームの世界 トランスポートソームの世界 2011 Disclose to all
沼田朋大, 香西大輔, 高橋重成, 加藤賢太, 瓜生幸嗣, 山本伸一郎, 金子雄, 眞本達生, 森泰生 沼田朋大, 香西大輔, 高橋重成, 加藤賢太, 瓜生幸嗣, 山本伸一郎, 金子雄, 眞本達生, 森泰生 TRP チャネルの構造と多様な機能 TRP チャネルの構造と多様な機能 生化学 生化学 2009/11 Disclose to all
高橋 重成 高橋 重成 TRPチャネル TRPチャネル Medical Tribuneことばのカルテ Medical Tribuneことばのカルテ 2009/11 Disclose to all
高橋重成, 山本伸一郎, 森泰生 高橋重成, 山本伸一郎, 森泰生 酸化ストレス作動性TRP チャネルの化学生理 酸化ストレス作動性TRP チャネルの化学生理 実験医学 実験医学 2009/09 Disclose to all
山本伸一郎, 高橋重成, 清中茂樹, 森泰生 山本伸一郎, 高橋重成, 清中茂樹, 森泰生 活性化学種感応のチャネル機構の探求 活性化学種感応のチャネル機構の探求 蛋白質核酸酵素 蛋白質核酸酵素 2009 Disclose to all
清中茂樹, 高橋重成, 香西大輔, 森泰生 清中茂樹, 高橋重成, 香西大輔, 森泰生 化学物質の感覚分子生物学―TRPチャネルはどのように物質を感知し脳へ伝えるか― 化学物質の感覚分子生物学―TRPチャネルはどのように物質を感知し脳へ伝えるか― 化学 化学 2009 Disclose to all
高橋重成, 秋山智志, 水野雄介, 井上隆司, 森泰生 高橋重成, 秋山智志, 水野雄介, 井上隆司, 森泰生 TRPCチャネルによる血管トーヌスの調節 TRPCチャネルによる血管トーヌスの調節 医学のあゆみ 医学のあゆみ 2007/12 Disclose to all
清中茂樹, 加藤賢太, 高橋重成, 正木隆男, 森泰生 清中茂樹, 加藤賢太, 高橋重成, 正木隆男, 森泰生 カルシウムシグナル制御チャネルの作用化合物と創薬 カルシウムシグナル制御チャネルの作用化合物と創薬 医学のあゆみ 医学のあゆみ 2007 Disclose to all

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Title language:
Awards
Title(Japanese) Title(English) Organization name(Japanese) Organization name(English) Date
文部科学大臣表彰 若手科学者賞 文部科学省 2020/04/07
鈴木紘一メモリアル賞 日本生化学会 2011/09/11
優秀発表賞 特定領域研究「G蛋白質シグナル」&「膜輸送複合体」合同若手ワークショップ2008 2008/01/27
鈴木紘一メモリアル賞 日本生化学会 2012/12/16
佐川喜一賞 日本生理学会 2013/03/28
井上研究奨励賞 井上科学振興財団 2014/02/04
"Hot topic" Research The Society for Neuroscience 2011/08/11
Newspaper articles
Title Media name Column name Date
体内摂取酸素量調節たんぱく質 読売新聞 2011/08/29
タンパク質「TRPA1」 産経新聞 2011/09/01
体内酸素センサー発見 京都新聞 2011/08/29
たんぱく質「TRPA1」 酸素の体内供給制御 日刊工業新聞 2011/08/29
たんぱく質 酸素濃度を検知 日経産業新聞 2011/08/29
酸素 必要なのに時には毒性 体内でどう処理する? 科学新聞 2011/09/16
Study / Research groups you organized
Group name Organization name Date
酸応答・適応機構の先駆的研究シンポジウム 第93回日本生化学会大会  2020/09/14
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
学術変革領域研究(B) Representative pH応答生物学の創成 2020/10/02-2022/03/31
学術変革領域研究(B) Representative pHストレス適応を司るpH誘導型転写因子の実体解明 2020/10/02-2022/03/31
Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
分子生物化学 Molecular Biology 前期集中 工学研究科 2020/04-2021/03
生物化学工学 Biochemical Engineering 後期 工学部 2020/04-2021/03
生物化学工学 Biochemical Engineering 後期 工学部 2021/04-2022/03
Academic organizaions (conference chair)
Organization name Group name Date
第17回MPO研究会 2011/10/29