濱谷 美緒

Last Update: 2021/06/23 09:41:46

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Name(Kanji/Kana/Abecedarium Latinum)
濱谷 美緒/ハマタニ ミオ/Hamatani, Mio
Primary Affiliation(Org1/Job title)
Institute for Advanced Study/Program-Specific Assistant Professor
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
博士(医学) 京都大学
researchmap URL
https://researchmap.jp/hamatanm
Research Topics
(Japanese)
遺伝性白質脳症におけるミクログリアの役割、ミエリン糖脂質の多発性硬化症病態への関わり
(English)
Microglia in hereditary leukoencephalopathy & Immunological roles of myelin glycolipid in multiple sclerosis
Overview of the research
(Japanese)
1) 神経軸索スフェロイドおよび色素性グリアを伴う成人発症白質脳症(ALSP)は、ミクログリア機能に重要な変化が示唆される単一遺伝子変異による白質脳症です。ミクログリアはヒトと代表的な実験動物であるマウスでは大きな差があることが知られ、ヒトiPS細胞とALSP脳組織を用いてミクログリアの機能評価を行うことで病態を明らかにしたいと考えています。 2) 多発性硬化症は、病初期には再発寛解を繰り返すが、徐々に再発によらない症状進行を示す進行型に移行します。進行型多発性硬化症への移行機序や病態は不明です。私たちはミエリン糖脂質が免疫修飾作用を持ち、進行型多発性硬化症患者の末梢血リンパ球では反応性が異なることを明らかにしました。今後分子機構を解明することで、病態解明や治療起点の発見につなげたいと考えています。
(English)
1. Microglia in hereditary leukoencephalopathy Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a hereditary leukoencephalopathy caused by gene mutation in colony stimulating factor 1 receptor. Microglial dysfunction is assumed as essential, though the detailed mechanism remains unknown. My colleagues and I are now trying to reveal the ALSP pathogenesis by using human materials such as induced pluripotent stem cells and brain tissue. 2. Immunological roles of myelin glycolipid in multiple sclerosis Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, characterized by relapse-remitting disease course in the early phase followed by disability progression in the later stage. Whereas chronic inflammation accompanied with degeneration are the key pathological features, the pathogenesis of MS, particularly progressive MS (PMS) remains unknown. Sulfatide is one of the major glycolipid components of myelin. We had found that a myelin-glycolipid sulfatide displayed an ability to suppress the proliferation of polyclonally activated human T cells which was impaired in T cells obtained from patients with MS in higher disability status. We are now trying to identify the molecular mechanism of sulfatide-induced suppression of T cell proliferation and its alteration through the MS disease stages. This study will provide novel insights into the pathogenesis of MS, particularly disease progression.
Fields of research (key words)
Key words(Japanese) Key words(English)
神経科学 Neuroscience
神経内科学 Neurology
神経免疫学 Neuroimmunology
免疫学 Immunology
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Shinji Ashida, Hirofumi Ochi, Mio Hamatani, Chihiro Fujii, Kimitoshi Kimura, Yoichiro Okada, Yuichiro Hashi, Kazuyuki Kawamura, Hideki Ueno, Ryosuke Takahashi, Toshiki Mizuno, Takayuki Kondo Shinji Ashida, Hirofumi Ochi, Mio Hamatani, Chihiro Fujii, Kimitoshi Kimura, Yoichiro Okada, Yuichiro Hashi, Kazuyuki Kawamura, Hideki Ueno, Ryosuke Takahashi, Toshiki Mizuno, Takayuki Kondo Shinji Ashida, Hirofumi Ochi, Mio Hamatani, Chihiro Fujii, Kimitoshi Kimura, Yoichiro Okada, Yuichiro Hashi, Kazuyuki Kawamura, Hideki Ueno, Ryosuke Takahashi, Toshiki Mizuno, Takayuki Kondo Immune Skew of Circulating Follicular Helper T Cells Associates With Myasthenia Gravis Severity. Immune Skew of Circulating Follicular Helper T Cells Associates With Myasthenia Gravis Severity. Immune Skew of Circulating Follicular Helper T Cells Associates With Myasthenia Gravis Severity. Neurology(R) neuroimmunology & neuroinflammation, 8, 2 Neurology(R) neuroimmunology & neuroinflammation, 8, 2 Neurology(R) neuroimmunology & neuroinflammation, 8, 2 2021/03 English Research paper(scientific journal) Disclose to all
Mio Hamatani, Hirofumi Yamashita, Hirofumi Ochi, Shinji Ashida, Yuichiro Hashi, Yoichiro Okada, Chihiro Fujii, Kazuyuki Kawamura, Riko Kitazawa, Masanori Nakagawa, Toshiki Mizuno, Ryosuke Takahashi, Takayuki Kondo Mio Hamatani, Hirofumi Yamashita, Hirofumi Ochi, Shinji Ashida, Yuichiro Hashi, Yoichiro Okada, Chihiro Fujii, Kazuyuki Kawamura, Riko Kitazawa, Masanori Nakagawa, Toshiki Mizuno, Ryosuke Takahashi, Takayuki Kondo Mio Hamatani, Hirofumi Yamashita, Hirofumi Ochi, Shinji Ashida, Yuichiro Hashi, Yoichiro Okada, Chihiro Fujii, Kazuyuki Kawamura, Riko Kitazawa, Masanori Nakagawa, Toshiki Mizuno, Ryosuke Takahashi, Takayuki Kondo Altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: A clue to the pathomechanism of microglial dyshomeostasis. Altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: A clue to the pathomechanism of microglial dyshomeostasis. Altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: A clue to the pathomechanism of microglial dyshomeostasis. Neurobiology of disease, 140, 104867-104867 Neurobiology of disease, 140, 104867-104867 Neurobiology of disease, 140, 104867-104867 2020/07 English Research paper(scientific journal) Disclose to all
Yoichiro Okada, Hirofumi Ochi, Chihiro Fujii, Yuichiro Hashi, Mio Hamatani, Shinji Ashida, Kazuyuki Kawamura, Hirofumi Kusaka, Sadayuki Matsumoto, Masanori Nakagawa, Toshiki Mizuno, Ryosuke Takahashi, Takayuki Kondo Yoichiro Okada, Hirofumi Ochi, Chihiro Fujii, Yuichiro Hashi, Mio Hamatani, Shinji Ashida, Kazuyuki Kawamura, Hirofumi Kusaka, Sadayuki Matsumoto, Masanori Nakagawa, Toshiki Mizuno, Ryosuke Takahashi, Takayuki Kondo Yoichiro Okada, Hirofumi Ochi, Chihiro Fujii, Yuichiro Hashi, Mio Hamatani, Shinji Ashida, Kazuyuki Kawamura, Hirofumi Kusaka, Sadayuki Matsumoto, Masanori Nakagawa, Toshiki Mizuno, Ryosuke Takahashi, Takayuki Kondo Signaling via toll-like receptor 4 and CD40 in B cells plays a regulatory role in the pathogenesis of multiple sclerosis through interleukin-10 production. Signaling via toll-like receptor 4 and CD40 in B cells plays a regulatory role in the pathogenesis of multiple sclerosis through interleukin-10 production. Signaling via toll-like receptor 4 and CD40 in B cells plays a regulatory role in the pathogenesis of multiple sclerosis through interleukin-10 production. Journal of autoimmunity, 88, 103-113 Journal of autoimmunity, 88, 103-113 Journal of autoimmunity, 88, 103-113 2018/03 English Research paper(scientific journal) Disclose to all
Mio Hamatani, Naoto Jingami, Yoshinori Tsurusaki, Shino Shimada, Keiko Shimojima, Megumi Asada-Utsugi, Kenji Yoshinaga, Norihito Uemura, Hirofumi Yamashita, Kengo Uemura, Ryosuke Takahashi, Naomichi Matsumoto, Toshiyuki Yamamoto Mio Hamatani, Naoto Jingami, Yoshinori Tsurusaki, Shino Shimada, Keiko Shimojima, Megumi Asada-Utsugi, Kenji Yoshinaga, Norihito Uemura, Hirofumi Yamashita, Kengo Uemura, Ryosuke Takahashi, Naomichi Matsumoto, Toshiyuki Yamamoto Mio Hamatani, Naoto Jingami, Yoshinori Tsurusaki, Shino Shimada, Keiko Shimojima, Megumi Asada-Utsugi, Kenji Yoshinaga, Norihito Uemura, Hirofumi Yamashita, Kengo Uemura, Ryosuke Takahashi, Naomichi Matsumoto, Toshiyuki Yamamoto The first Japanese case of leukodystrophy with ovarian failure arising from novel compound heterozygous AARS2 mutations. The first Japanese case of leukodystrophy with ovarian failure arising from novel compound heterozygous AARS2 mutations. The first Japanese case of leukodystrophy with ovarian failure arising from novel compound heterozygous AARS2 mutations. Journal of human genetics, 61, 10, 899-902 Journal of human genetics, 61, 10, 899-902 Journal of human genetics, 61, 10, 899-902 2016/10 English Research paper(scientific journal) Disclose to all
Yasuhiro Hamatani, Moritake Iguchi, Michikazu Nakamura, Ryo Ohtani, Yugo Yamashita, Daisuke Takagi, Takashi Unoki, Mitsuru Ishii, Nobutoyo Masunaga, Hisashi Ogawa, Mio Hamatani, Mitsuru Abe, Masaharu Akao Yasuhiro Hamatani, Moritake Iguchi, Michikazu Nakamura, Ryo Ohtani, Yugo Yamashita, Daisuke Takagi, Takashi Unoki, Mitsuru Ishii, Nobutoyo Masunaga, Hisashi Ogawa, Mio Hamatani, Mitsuru Abe, Masaharu Akao Yasuhiro Hamatani, Moritake Iguchi, Michikazu Nakamura, Ryo Ohtani, Yugo Yamashita, Daisuke Takagi, Takashi Unoki, Mitsuru Ishii, Nobutoyo Masunaga, Hisashi Ogawa, Mio Hamatani, Mitsuru Abe, Masaharu Akao Incidence and predictors of ischemic stroke during hospitalization for congestive heart failure. Incidence and predictors of ischemic stroke during hospitalization for congestive heart failure. Incidence and predictors of ischemic stroke during hospitalization for congestive heart failure. Heart and vessels, 31, 7, 1154-61 Heart and vessels, 31, 7, 1154-61 Heart and vessels, 31, 7, 1154-61 2016/07 English Research paper(scientific journal) Disclose to all
Mio Hamatani, Naoto Jingami, Kengo Uemura, Naoe Nakasone, Hisanori Kinoshita, Hodaka Yamakado, Haruaki Ninomiya, Ryosuke Takahashi Mio Hamatani, Naoto Jingami, Kengo Uemura, Naoe Nakasone, Hisanori Kinoshita, Hodaka Yamakado, Haruaki Ninomiya, Ryosuke Takahashi Mio Hamatani, Naoto Jingami, Kengo Uemura, Naoe Nakasone, Hisanori Kinoshita, Hodaka Yamakado, Haruaki Ninomiya, Ryosuke Takahashi A case of variant biochemical phenotype of Niemann-Pick disease type C accompanying savant syndrome. A case of variant biochemical phenotype of Niemann-Pick disease type C accompanying savant syndrome. A case of variant biochemical phenotype of Niemann-Pick disease type C accompanying savant syndrome. Rinsho shinkeigaku = Clinical neurology, 56, 6, 424-9 Rinsho shinkeigaku = Clinical neurology, 56, 6, 424-9 Rinsho shinkeigaku = Clinical neurology, 56, 6, 424-9 2016/06/22 Japanese Research paper(scientific journal) Disclose to all
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