伊藤 貴浩

Last Update: 2021/08/21 18:21:39

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Name(Kanji/Kana/Abecedarium Latinum)
伊藤 貴浩/イトウ タカヒロ/Ito, Takahiro
Primary Affiliation(Org1/Job title)
Institute for Frontier Life and Medical Sciences (inFront)/Professor
Affiliated programs (koza)
Org1 Job title
Graduate School of Medicine Professor
Graduate School of Medicine Professor
Graduate School of Pharmaceutical Sciences Professor
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(薬学) M.Sc. 東京大学 The University of Tokyo
博士(薬学) Ph.D. 東京大学 The University of Tokyo
researchmap URL
https://researchmap.jp/takahiroito
Research Topics
(English)
Regulation of cell fates in stem cells and cancer
Overview of the research
(English)
What determines how stem cells and cancer behave? The primary goal of our research is to understand the molecular basis of self-renewal and differentiation in stem cells and cancer, i.e. cell fates. Specifically, we study hematopoiesis and myogenesis to identify cellular machinery that regulates tissue homeostasis and regeneration as well as molecular drivers of transformation that lead to human malignancies such as leukemia. We are particularly interested in the stem cell regulatory circuits governed by RNA binding proteins and cellular metabolism. Recent studies, including our own work, have revealed that normal stem cells and cancer share similar cellular hierarchy and regulatory signals while several components are distinct in these tissues. These results showed us that understanding machineries operating in stem cells and cancer could help us to develop new effective approaches to treat human diseases including cancers.
Fields of research (key words)
Key words(Japanese) Key words(English)
がん cancer
幹細胞 stem cells
代謝 metabolism
造血 hematopoiesis
白血病 leukemia
RNA RNA
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Kyle Spinler, Jeevisha Bajaj, Takahiro Ito, Bryan Zimdahl, Michael Hamilton, Armin Ahmadi, Claire S Koechlein, Nikki Lytle, Hyog Young Kwon, Ferdous Anower-E-Khuda, Hao Sun, Allen Blevins, Joi Weeks, Marcie Kritzik, Jan Karlseder, Mark H Ginsberg, Pyong Woo Park, Jeffrey D Esko, Tannishtha Reya Kyle Spinler, Jeevisha Bajaj, Takahiro Ito, Bryan Zimdahl, Michael Hamilton, Armin Ahmadi, Claire S Koechlein, Nikki Lytle, Hyog Young Kwon, Ferdous Anower-E-Khuda, Hao Sun, Allen Blevins, Joi Weeks, Marcie Kritzik, Jan Karlseder, Mark H Ginsberg, Pyong Woo Park, Jeffrey D Esko, Tannishtha Reya Kyle Spinler, Jeevisha Bajaj, Takahiro Ito, Bryan Zimdahl, Michael Hamilton, Armin Ahmadi, Claire S Koechlein, Nikki Lytle, Hyog Young Kwon, Ferdous Anower-E-Khuda, Hao Sun, Allen Blevins, Joi Weeks, Marcie Kritzik, Jan Karlseder, Mark H Ginsberg, Pyong Woo Park, Jeffrey D Esko, Tannishtha Reya A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia. A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia. A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia. Nature communications, 11, 1, 5998-5998 Nature communications, 11, 1, 5998-5998 Nature communications, 11, 1, 5998-5998 2020/11/26 Refereed English Research paper(scientific journal) Disclose to all
Takuya Fujiwara, Ayuna Hattori, Takahiro Ito, Takashi Funatsu, Makoto Tsunoda Takuya Fujiwara, Ayuna Hattori, Takahiro Ito, Takashi Funatsu, Makoto Tsunoda Takuya Fujiwara, Ayuna Hattori, Takahiro Ito, Takashi Funatsu, Makoto Tsunoda Analysis of intracellular α-keto acids by HPLC with fluorescence detection Analysis of intracellular α-keto acids by HPLC with fluorescence detection Analysis of intracellular α-keto acids by HPLC with fluorescence detection Analytical Methods, 12, 20, 2555-2559 Analytical Methods, 12, 20, 2555-2559 Analytical Methods, 12, 20, 2555-2559 2020/05/21 Refereed English Research paper(scientific journal) Disclose to all
Michael T. Judge, Yue Wu, Fariba Tayyari, Ayuna Hattori, John Glushka, Takahiro Ito, Jonathan Arnold, Arthur S. Edison Michael T. Judge, Yue Wu, Fariba Tayyari, Ayuna Hattori, John Glushka, Takahiro Ito, Jonathan Arnold, Arthur S. Edison Michael T. Judge, Yue Wu, Fariba Tayyari, Ayuna Hattori, John Glushka, Takahiro Ito, Jonathan Arnold, Arthur S. Edison Continuous in vivo Metabolism by NMR Continuous in vivo Metabolism by NMR Continuous in vivo Metabolism by NMR Frontiers in Molecular Biosciences, 6 Frontiers in Molecular Biosciences, 6 Frontiers in Molecular Biosciences, 6 2019/04/30 Refereed English Research paper(scientific journal) Disclose to all
Ayuna Hattori, Makoto Tsunoda, Takaaki Konuma, Masayuki Kobayashi, Tamas Nagy, John Glushka, Fariba Tayyari, Daniel McSkimming, Natarajan Kannan, Arinobu Tojo, Arthur S Edison, Takahiro Ito Ayuna Hattori, Makoto Tsunoda, Takaaki Konuma, Masayuki Kobayashi, Tamas Nagy, John Glushka, Fariba Tayyari, Daniel McSkimming, Natarajan Kannan, Arinobu Tojo, Arthur S Edison, Takahiro Ito Ayuna Hattori, Makoto Tsunoda, Takaaki Konuma, Masayuki Kobayashi, Tamas Nagy, John Glushka, Fariba Tayyari, Daniel McSkimming, Natarajan Kannan, Arinobu Tojo, Arthur S Edison, Takahiro Ito Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia. Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia. Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia. Nature, 545, 7655, 500-504 Nature, 545, 7655, 500-504 Nature, 545, 7655, 500-504 2017/05/25 Refereed English Research paper(scientific journal) Disclose to all
Ayuna Hattori, Daniel McSkimming, Natarajan Kannan, Takahiro Ito Ayuna Hattori, Daniel McSkimming, Natarajan Kannan, Takahiro Ito Ayuna Hattori, Daniel McSkimming, Natarajan Kannan, Takahiro Ito RNA binding protein MSI2 positively regulates FLT3 expression in myeloid leukemia. RNA binding protein MSI2 positively regulates FLT3 expression in myeloid leukemia. RNA binding protein MSI2 positively regulates FLT3 expression in myeloid leukemia. Leukemia research, 54, 47-54 Leukemia research, 54, 47-54 Leukemia research, 54, 47-54 2017/03 Refereed English Research paper(scientific journal) Disclose to all
Ayuna Hattori, Takahiro Ito, Makoto Tsunoda Ayuna Hattori, Takahiro Ito, Makoto Tsunoda Ayuna Hattori, Takahiro Ito, Makoto Tsunoda Analysis of Branched-Chain Keto Acids in Cell Extracts by HPLC-Fluorescence Detection Analysis of Branched-Chain Keto Acids in Cell Extracts by HPLC-Fluorescence Detection Analysis of Branched-Chain Keto Acids in Cell Extracts by HPLC-Fluorescence Detection CHROMATOGRAPHY, 38, 3, 129-133 CHROMATOGRAPHY, 38, 3, 129-133 CHROMATOGRAPHY, 38, 3, 129-133 2017 Refereed English Research paper(scientific journal) Disclose to all
Claire S Koechlein, Jeffrey R Harris, Timothy K Lee, Joi Weeks, Raymond G Fox, Bryan Zimdahl, Takahiro Ito, Allen Blevins, Seung-Hye Jung, John P Chute, Amit Chourasia, Markus W Covert, Tannishtha Reya Claire S Koechlein, Jeffrey R Harris, Timothy K Lee, Joi Weeks, Raymond G Fox, Bryan Zimdahl, Takahiro Ito, Allen Blevins, Seung-Hye Jung, John P Chute, Amit Chourasia, Markus W Covert, Tannishtha Reya Claire S Koechlein, Jeffrey R Harris, Timothy K Lee, Joi Weeks, Raymond G Fox, Bryan Zimdahl, Takahiro Ito, Allen Blevins, Seung-Hye Jung, John P Chute, Amit Chourasia, Markus W Covert, Tannishtha Reya High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo. High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo. High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo. Nature communications, 7, 12169-12169 Nature communications, 7, 12169-12169 Nature communications, 7, 12169-12169 2016/07/18 Refereed English Research paper(scientific journal) Disclose to all
Raymond G Fox, Nikki K Lytle, Dawn V Jaquish, Frederick D Park, Takahiro Ito, Jeevisha Bajaj, Claire S Koechlein, Bryan Zimdahl, Masato Yano, Janel Kopp, Marcie Kritzik, Jason Sicklick, Maike Sander, Paul M Grandgenett, Michael A Hollingsworth, Shinsuke Shibata, Donald Pizzo, Mark Valasek, Roman Sasik, Miriam Scadeng, Hideyuki Okano, Youngsoo Kim, A Robert MacLeod, Andrew M Lowy, Tannishtha Reya Raymond G Fox, Nikki K Lytle, Dawn V Jaquish, Frederick D Park, Takahiro Ito, Jeevisha Bajaj, Claire S Koechlein, Bryan Zimdahl, Masato Yano, Janel Kopp, Marcie Kritzik, Jason Sicklick, Maike Sander, Paul M Grandgenett, Michael A Hollingsworth, Shinsuke Shibata, Donald Pizzo, Mark Valasek, Roman Sasik, Miriam Scadeng, Hideyuki Okano, Youngsoo Kim, A Robert MacLeod, Andrew M Lowy, Tannishtha Reya Raymond G Fox, Nikki K Lytle, Dawn V Jaquish, Frederick D Park, Takahiro Ito, Jeevisha Bajaj, Claire S Koechlein, Bryan Zimdahl, Masato Yano, Janel Kopp, Marcie Kritzik, Jason Sicklick, Maike Sander, Paul M Grandgenett, Michael A Hollingsworth, Shinsuke Shibata, Donald Pizzo, Mark Valasek, Roman Sasik, Miriam Scadeng, Hideyuki Okano, Youngsoo Kim, A Robert MacLeod, Andrew M Lowy, Tannishtha Reya Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature, 534, 7607, 407-411 Nature, 534, 7607, 407-411 Nature, 534, 7607, 407-411 2016/06/16 Refereed English Research paper(scientific journal) Disclose to all
Ayuna Hattori, Kristina Buac, Takahiro Ito Ayuna Hattori, Kristina Buac, Takahiro Ito Ayuna Hattori, Kristina Buac, Takahiro Ito Regulation of Stem Cell Self-Renewal and Oncogenesis by RNA-Binding Proteins; RNA PROCESSING: DISEASE AND GENOME-WIDE PROBING Regulation of Stem Cell Self-Renewal and Oncogenesis by RNA-Binding Proteins; RNA PROCESSING: DISEASE AND GENOME-WIDE PROBING Regulation of Stem Cell Self-Renewal and Oncogenesis by RNA-Binding Proteins; RNA PROCESSING: DISEASE AND GENOME-WIDE PROBING Advances in Experimental Medicine and Biology, 907, 153-188 Advances in Experimental Medicine and Biology, 907, 153-188 Advances in Experimental Medicine and Biology, 907, 153-188 2016 Refereed English Research paper(scientific journal) Disclose to all
Hyog Young Kwon, Jeevisha Bajaj, Takahiro Ito, Allen Blevins, Takaaki Konuma, Joi Weeks, Nikki K Lytle, Claire S Koechlein, David Rizzieri, Charles Chuah, Vivian G Oehler, Roman Sasik, Gary Hardiman, Tannishtha Reya Hyog Young Kwon, Jeevisha Bajaj, Takahiro Ito, Allen Blevins, Takaaki Konuma, Joi Weeks, Nikki K Lytle, Claire S Koechlein, David Rizzieri, Charles Chuah, Vivian G Oehler, Roman Sasik, Gary Hardiman, Tannishtha Reya Hyog Young Kwon, Jeevisha Bajaj, Takahiro Ito, Allen Blevins, Takaaki Konuma, Joi Weeks, Nikki K Lytle, Claire S Koechlein, David Rizzieri, Charles Chuah, Vivian G Oehler, Roman Sasik, Gary Hardiman, Tannishtha Reya Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia. Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia. Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia. Cell stem cell, 17, 2, 152-164 Cell stem cell, 17, 2, 152-164 Cell stem cell, 17, 2, 152-164 2015/08/06 Refereed English Research paper(scientific journal) Disclose to all
William Lento, Takahiro Ito, Chen Zhao, Jeffrey R Harris, Wei Huang, Chen Jiang, Kouros Owzar, Sadhna Piryani, Luigi Racioppi, Nelson Chao, Tannishtha Reya William Lento, Takahiro Ito, Chen Zhao, Jeffrey R Harris, Wei Huang, Chen Jiang, Kouros Owzar, Sadhna Piryani, Luigi Racioppi, Nelson Chao, Tannishtha Reya William Lento, Takahiro Ito, Chen Zhao, Jeffrey R Harris, Wei Huang, Chen Jiang, Kouros Owzar, Sadhna Piryani, Luigi Racioppi, Nelson Chao, Tannishtha Reya Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration. Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration. Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration. Genes & development, 28, 9, 995-1004 Genes & development, 28, 9, 995-1004 Genes & development, 28, 9, 995-1004 2014/05/01 Refereed English Research paper(scientific journal) Disclose to all
Bryan Zimdahl, Takahiro Ito, Allen Blevins, Jeevisha Bajaj, Takaaki Konuma, Joi Weeks, Claire S Koechlein, Hyog Young Kwon, Omead Arami, David Rizzieri, H Elizabeth Broome, Charles Chuah, Vivian G Oehler, Roman Sasik, Gary Hardiman, Tannishtha Reya Bryan Zimdahl, Takahiro Ito, Allen Blevins, Jeevisha Bajaj, Takaaki Konuma, Joi Weeks, Claire S Koechlein, Hyog Young Kwon, Omead Arami, David Rizzieri, H Elizabeth Broome, Charles Chuah, Vivian G Oehler, Roman Sasik, Gary Hardiman, Tannishtha Reya Bryan Zimdahl, Takahiro Ito, Allen Blevins, Jeevisha Bajaj, Takaaki Konuma, Joi Weeks, Claire S Koechlein, Hyog Young Kwon, Omead Arami, David Rizzieri, H Elizabeth Broome, Charles Chuah, Vivian G Oehler, Roman Sasik, Gary Hardiman, Tannishtha Reya Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia. Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia. Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia. Nature genetics, 46, 3, 245-52 Nature genetics, 46, 3, 245-52 Nature genetics, 46, 3, 245-52 2014/03 Refereed English Research paper(scientific journal) Disclose to all
Takahiro Ito Takahiro Ito Takahiro Ito Stem cell maintenance and disease progression in chronic myeloid leukemia. Stem cell maintenance and disease progression in chronic myeloid leukemia. Stem cell maintenance and disease progression in chronic myeloid leukemia. International journal of hematology, 98, 6, 641-7 International journal of hematology, 98, 6, 641-7 International journal of hematology, 98, 6, 641-7 2013/12 Refereed English Research paper(scientific journal) Disclose to all
Manabu Kurokawa, Takahiro Ito, Chih-Sheng Yang, Chen Zhao, Andrew N Macintyre, David A Rizzieri, Jeffrey C Rathmell, Michael W Deininger, Tannishtha Reya, Sally Kornbluth Manabu Kurokawa, Takahiro Ito, Chih-Sheng Yang, Chen Zhao, Andrew N Macintyre, David A Rizzieri, Jeffrey C Rathmell, Michael W Deininger, Tannishtha Reya, Sally Kornbluth Manabu Kurokawa, Takahiro Ito, Chih-Sheng Yang, Chen Zhao, Andrew N Macintyre, David A Rizzieri, Jeffrey C Rathmell, Michael W Deininger, Tannishtha Reya, Sally Kornbluth Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. Proceedings of the National Academy of Sciences of the United States of America, 110, 6, 2300-5 Proceedings of the National Academy of Sciences of the United States of America, 110, 6, 2300-5 Proceedings of the National Academy of Sciences of the United States of America, 110, 6, 2300-5 2013/02/05 Refereed English Research paper(scientific journal) Disclose to all
Heather A Himburg, Jeffrey R Harris, Takahiro Ito, Pamela Daher, J Lauren Russell, Mamle Quarmyne, Phuong L Doan, Katherine Helms, Mai Nakamura, Emma Fixsen, Gonzalo Herradon, Tannishtha Reya, Nelson J Chao, Sheila Harroch, John P Chute Heather A Himburg, Jeffrey R Harris, Takahiro Ito, Pamela Daher, J Lauren Russell, Mamle Quarmyne, Phuong L Doan, Katherine Helms, Mai Nakamura, Emma Fixsen, Gonzalo Herradon, Tannishtha Reya, Nelson J Chao, Sheila Harroch, John P Chute Heather A Himburg, Jeffrey R Harris, Takahiro Ito, Pamela Daher, J Lauren Russell, Mamle Quarmyne, Phuong L Doan, Katherine Helms, Mai Nakamura, Emma Fixsen, Gonzalo Herradon, Tannishtha Reya, Nelson J Chao, Sheila Harroch, John P Chute Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. Cell reports, 2, 4, 964-75 Cell reports, 2, 4, 964-75 Cell reports, 2, 4, 964-75 2012/10/25 Refereed English Research paper(scientific journal) Disclose to all
Mark Fereshteh, Takahiro Ito, Jeffrey J Kovacs, Chen Zhao, Hyog Young Kwon, Valerie Tornini, Takaaki Konuma, Minyong Chen, Robert J Lefkowitz, Tannishtha Reya Mark Fereshteh, Takahiro Ito, Jeffrey J Kovacs, Chen Zhao, Hyog Young Kwon, Valerie Tornini, Takaaki Konuma, Minyong Chen, Robert J Lefkowitz, Tannishtha Reya Mark Fereshteh, Takahiro Ito, Jeffrey J Kovacs, Chen Zhao, Hyog Young Kwon, Valerie Tornini, Takaaki Konuma, Minyong Chen, Robert J Lefkowitz, Tannishtha Reya β-Arrestin2 mediates the initiation and progression of myeloid leukemia. β-Arrestin2 mediates the initiation and progression of myeloid leukemia. β-Arrestin2 mediates the initiation and progression of myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America, 109, 31, 12532-7 Proceedings of the National Academy of Sciences of the United States of America, 109, 31, 12532-7 Proceedings of the National Academy of Sciences of the United States of America, 109, 31, 12532-7 2012/07/31 Refereed English Research paper(scientific journal) Disclose to all
Takahiro Ito, Bryan Zimdahl, Tannishtha Reya Takahiro Ito, Bryan Zimdahl, Tannishtha Reya Takahiro Ito, Bryan Zimdahl, Tannishtha Reya aSIRTing control over cancer stem cells. aSIRTing control over cancer stem cells. aSIRTing control over cancer stem cells. Cancer cell, 21, 2, 140-2 Cancer cell, 21, 2, 140-2 Cancer cell, 21, 2, 140-2 2012/02/14 Refereed English Research paper(scientific journal) Disclose to all
Takahiro Ito, Hyog Young Kwon, Bryan Zimdahl, Kendra L Congdon, Jordan Blum, William E Lento, Chen Zhao, Anand Lagoo, Gareth Gerrard, Letizia Foroni, John Goldman, Harriet Goh, Soo-Hyun Kim, Dong-Wook Kim, Charles Chuah, Vivian G Oehler, Jerald P Radich, Craig T Jordan, Tannishtha Reya Takahiro Ito, Hyog Young Kwon, Bryan Zimdahl, Kendra L Congdon, Jordan Blum, William E Lento, Chen Zhao, Anand Lagoo, Gareth Gerrard, Letizia Foroni, John Goldman, Harriet Goh, Soo-Hyun Kim, Dong-Wook Kim, Charles Chuah, Vivian G Oehler, Jerald P Radich, Craig T Jordan, Tannishtha Reya Takahiro Ito, Hyog Young Kwon, Bryan Zimdahl, Kendra L Congdon, Jordan Blum, William E Lento, Chen Zhao, Anand Lagoo, Gareth Gerrard, Letizia Foroni, John Goldman, Harriet Goh, Soo-Hyun Kim, Dong-Wook Kim, Charles Chuah, Vivian G Oehler, Jerald P Radich, Craig T Jordan, Tannishtha Reya Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature, 466, 7307, 765-8 Nature, 466, 7307, 765-8 Nature, 466, 7307, 765-8 2010/08/05 Refereed English Research paper(scientific journal) Disclose to all
Hiroshi Koyama, Tomofumi Ueda, Takahiro Ito, Kazuhisa Sekimizu Hiroshi Koyama, Tomofumi Ueda, Takahiro Ito, Kazuhisa Sekimizu Hiroshi Koyama, Tomofumi Ueda, Takahiro Ito, Kazuhisa Sekimizu Novel RNA polymerase II mutation suppresses transcriptional fidelity and oxidative stress sensitivity in rpb9Δ yeast Novel RNA polymerase II mutation suppresses transcriptional fidelity and oxidative stress sensitivity in rpb9Δ yeast Novel RNA polymerase II mutation suppresses transcriptional fidelity and oxidative stress sensitivity in rpb9Δ yeast Genes to Cells, 15, 2, 151-159 Genes to Cells, 15, 2, 151-159 Genes to Cells, 15, 2, 151-159 2010/02 Refereed English Research paper(scientific journal) Disclose to all
Makiko Nagata, Takahiro Ito, Nagisa Arimitsu, Hiroshi Koyama, Kazuhisa Sekimizu Makiko Nagata, Takahiro Ito, Nagisa Arimitsu, Hiroshi Koyama, Kazuhisa Sekimizu Makiko Nagata, Takahiro Ito, Nagisa Arimitsu, Hiroshi Koyama, Kazuhisa Sekimizu Transcription arrest relief by S-II/TFIIS during gene expression in erythroblast differentiation Transcription arrest relief by S-II/TFIIS during gene expression in erythroblast differentiation Transcription arrest relief by S-II/TFIIS during gene expression in erythroblast differentiation GENES TO CELLS, 14, 3, 371-380 GENES TO CELLS, 14, 3, 371-380 GENES TO CELLS, 14, 3, 371-380 2009/03 Refereed English Research paper(scientific journal) Disclose to all
Hiroshi Koyama, Eriko Sumiya, Makiko Nagata, Takahiro Ito, Kazuhisa Sekimizu Hiroshi Koyama, Eriko Sumiya, Makiko Nagata, Takahiro Ito, Kazuhisa Sekimizu Hiroshi Koyama, Eriko Sumiya, Makiko Nagata, Takahiro Ito, Kazuhisa Sekimizu Transcriptional repression of the IMD2 gene mediated by the transcriptional co-activator Sub1 Transcriptional repression of the IMD2 gene mediated by the transcriptional co-activator Sub1 Transcriptional repression of the IMD2 gene mediated by the transcriptional co-activator Sub1 GENES TO CELLS, 13, 11, 1113-1126 GENES TO CELLS, 13, 11, 1113-1126 GENES TO CELLS, 13, 11, 1113-1126 2008/11 Refereed English Research paper(scientific journal) Disclose to all
Hiroshi Koyama, Eriko Sumiya, Takahiro Ito, Kazuhisa Sekimizu Hiroshi Koyama, Eriko Sumiya, Takahiro Ito, Kazuhisa Sekimizu Hiroshi Koyama, Eriko Sumiya, Takahiro Ito, Kazuhisa Sekimizu Improved method for the PCR-based gene disruption in Saccharomyces cerevisiae Improved method for the PCR-based gene disruption in Saccharomyces cerevisiae Improved method for the PCR-based gene disruption in Saccharomyces cerevisiae FEMS Yeast Research, 8, 2, 193-194 FEMS Yeast Research, 8, 2, 193-194 FEMS Yeast Research, 8, 2, 193-194 2008/03 Refereed English Research paper(scientific journal) Disclose to all
Takahiro Ito, Kayoko Saso, Nagisa Arimitsu, Kazuhisa Sekimizu Takahiro Ito, Kayoko Saso, Nagisa Arimitsu, Kazuhisa Sekimizu Takahiro Ito, Kayoko Saso, Nagisa Arimitsu, Kazuhisa Sekimizu Defective FESTA/EAF2-mediated transcriptional activation in S-II-deficient embryonic stem cells Defective FESTA/EAF2-mediated transcriptional activation in S-II-deficient embryonic stem cells Defective FESTA/EAF2-mediated transcriptional activation in S-II-deficient embryonic stem cells Biochemical and Biophysical Research Communications, 363, 3, 603-609 Biochemical and Biophysical Research Communications, 363, 3, 603-609 Biochemical and Biophysical Research Communications, 363, 3, 603-609 2007/11/23 Refereed English Research paper(scientific journal) Disclose to all
Hiroshi Koyama, Takahiro Ito, Toshiyuki Nakanishi, Kazuhisa Sekimizu Hiroshi Koyama, Takahiro Ito, Toshiyuki Nakanishi, Kazuhisa Sekimizu Hiroshi Koyama, Takahiro Ito, Toshiyuki Nakanishi, Kazuhisa Sekimizu Stimulation of RNA polymerase II transcript cleavage activity contributes to maintain transcriptional fidelity in yeast Stimulation of RNA polymerase II transcript cleavage activity contributes to maintain transcriptional fidelity in yeast Stimulation of RNA polymerase II transcript cleavage activity contributes to maintain transcriptional fidelity in yeast Genes to Cells, 12, 5, 547-559 Genes to Cells, 12, 5, 547-559 Genes to Cells, 12, 5, 547-559 2007/05 Refereed English Research paper(scientific journal) Disclose to all
Makiko Nagata, Nagisa Arimitsu, Takahiro Ito, Kazuhisa Sekimizu Makiko Nagata, Nagisa Arimitsu, Takahiro Ito, Kazuhisa Sekimizu Makiko Nagata, Nagisa Arimitsu, Takahiro Ito, Kazuhisa Sekimizu Antioxidant N-acetyl-l-cysteine inhibits erythropoietin-induced differentiation of erythroid progenitors derived from mouse fetal liver Antioxidant N-acetyl-l-cysteine inhibits erythropoietin-induced differentiation of erythroid progenitors derived from mouse fetal liver Antioxidant N-acetyl-l-cysteine inhibits erythropoietin-induced differentiation of erythroid progenitors derived from mouse fetal liver Cell Biology International, 31, 3, 252-256 Cell Biology International, 31, 3, 252-256 Cell Biology International, 31, 3, 252-256 2007/03 Refereed English Research paper(scientific journal) Disclose to all
T Ito, N Arimitsu, M Takeuchi, N Kawamura, M Nagata, K Saso, N Akimitsu, H Hamamoto, S Natori, A Miyajima, K Sekimizu T Ito, N Arimitsu, M Takeuchi, N Kawamura, M Nagata, K Saso, N Akimitsu, H Hamamoto, S Natori, A Miyajima, K Sekimizu T Ito, N Arimitsu, M Takeuchi, N Kawamura, M Nagata, K Saso, N Akimitsu, H Hamamoto, S Natori, A Miyajima, K Sekimizu Transcription elongation factor S-II is required for definitive hematopoiesis Transcription elongation factor S-II is required for definitive hematopoiesis Transcription elongation factor S-II is required for definitive hematopoiesis Molecular and Cellular Biology, 26, 8, 3194-3203 Molecular and Cellular Biology, 26, 8, 3194-3203 Molecular and Cellular Biology, 26, 8, 3194-3203 2006/04 Refereed English Research paper(scientific journal) Disclose to all
Y Aramaki, K Ogawa, Y Toh, T Ito, N Akimitsu, H Hamamoto, K Sekimizu, K Matsusue, A Kono, H Iguchi, S Takiguchi Y Aramaki, K Ogawa, Y Toh, T Ito, N Akimitsu, H Hamamoto, K Sekimizu, K Matsusue, A Kono, H Iguchi, S Takiguchi Y Aramaki, K Ogawa, Y Toh, T Ito, N Akimitsu, H Hamamoto, K Sekimizu, K Matsusue, A Kono, H Iguchi, S Takiguchi Direct interaction between metastasis-associated protein 1 and endophilin 3 Direct interaction between metastasis-associated protein 1 and endophilin 3 Direct interaction between metastasis-associated protein 1 and endophilin 3 FEBS LETTERS, 579, 17, 3731-3736 FEBS LETTERS, 579, 17, 3731-3736 FEBS LETTERS, 579, 17, 3731-3736 2005/07 Refereed English Research paper(scientific journal) Disclose to all
Nobuyuki Kawamura, Kenji Kurokawa, Takahiro Ito, Hiroshi Hamamoto, Hiroshi Koyama, Chikara Kaito, Kazuhisa Sekimizu Nobuyuki Kawamura, Kenji Kurokawa, Takahiro Ito, Hiroshi Hamamoto, Hiroshi Koyama, Chikara Kaito, Kazuhisa Sekimizu Nobuyuki Kawamura, Kenji Kurokawa, Takahiro Ito, Hiroshi Hamamoto, Hiroshi Koyama, Chikara Kaito, Kazuhisa Sekimizu Participation of Rho-dependent transcription termination in oxidative stress sensitivity caused by an rpoB mutation Participation of Rho-dependent transcription termination in oxidative stress sensitivity caused by an rpoB mutation Participation of Rho-dependent transcription termination in oxidative stress sensitivity caused by an rpoB mutation Genes to Cells, 10, 5, 477-487 Genes to Cells, 10, 5, 477-487 Genes to Cells, 10, 5, 477-487 2005/03/31 Refereed English Research paper(scientific journal) Disclose to all
A Nakata, T Ito, M Nagata, S Hori, K Sekimizu A Nakata, T Ito, M Nagata, S Hori, K Sekimizu A Nakata, T Ito, M Nagata, S Hori, K Sekimizu GRIP1 tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1 GRIP1 tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1 GRIP1 tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1 Genes to Cells, 9, 11, 1125-1135 Genes to Cells, 9, 11, 1125-1135 Genes to Cells, 9, 11, 1125-1135 2004/11 Refereed English Research paper(scientific journal) Disclose to all
H Koyama, T Ito, T Nakanishi, N Kawamura, K Sekimizu H Koyama, T Ito, T Nakanishi, N Kawamura, K Sekimizu H Koyama, T Ito, T Nakanishi, N Kawamura, K Sekimizu Transcription elongation factor S-II maintains transcriptional fidelity and confers oxidative stress resistance Transcription elongation factor S-II maintains transcriptional fidelity and confers oxidative stress resistance Transcription elongation factor S-II maintains transcriptional fidelity and confers oxidative stress resistance Genes to Cells, 8, 10, 779-788 Genes to Cells, 8, 10, 779-788 Genes to Cells, 8, 10, 779-788 2003/10 Refereed English Research paper(scientific journal) Disclose to all
K Saso, T Ito, S Natori, K Sekimizu K Saso, T Ito, S Natori, K Sekimizu K Saso, T Ito, S Natori, K Sekimizu Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II Journal of Biochemistry, 133, 4, 493-500 Journal of Biochemistry, 133, 4, 493-500 Journal of Biochemistry, 133, 4, 493-500 2003/04 Refereed English Research paper(scientific journal) Disclose to all
T Ito, MF Seldin, MM Taketo, T Kubo, S Natori T Ito, MF Seldin, MM Taketo, T Kubo, S Natori T Ito, MF Seldin, MM Taketo, T Kubo, S Natori Gene structure and chromosome mapping of mouse transcription elongation factor S-II (Tcea1) Gene structure and chromosome mapping of mouse transcription elongation factor S-II (Tcea1) Gene structure and chromosome mapping of mouse transcription elongation factor S-II (Tcea1) Gene, 244, 1-2, 55-63 Gene, 244, 1-2, 55-63 Gene, 244, 1-2, 55-63 2000/02 Refereed English Research paper(scientific journal) Disclose to all
T Ito, MF Seldin, MM Taketo, T Kubo, S Natori T Ito, MF Seldin, MM Taketo, T Kubo, S Natori T Ito, MF Seldin, MM Taketo, T Kubo, S Natori Gene organization and chromosome mapping of the testis-specific S-II Gene organization and chromosome mapping of the testis-specific S-II Gene organization and chromosome mapping of the testis-specific S-II Mammalian Genome, 9, 11, 915-917 Mammalian Genome, 9, 11, 915-917 Mammalian Genome, 9, 11, 915-917 1998/11 Refereed English Research paper(scientific journal) Disclose to all
T Ito, QH Xu, H Takeuchi, T Kubo, S Natori T Ito, QH Xu, H Takeuchi, T Kubo, S Natori T Ito, QH Xu, H Takeuchi, T Kubo, S Natori Spermatocyte-specific expression of the gene for mouse testis-specific transcription elongation factor S-II Spermatocyte-specific expression of the gene for mouse testis-specific transcription elongation factor S-II Spermatocyte-specific expression of the gene for mouse testis-specific transcription elongation factor S-II FEBS Letters, 385, 1-2, 21-24 FEBS Letters, 385, 1-2, 21-24 FEBS Letters, 385, 1-2, 21-24 1996/04 Refereed English Research paper(scientific journal) Disclose to all

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Title language:
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
国際共同研究加速基金(帰国発展研究) Representative RNA結合タンハ?クMSI2の限定分解によるか?ん幹細胞の運命制御機構 (2019年度分) 2019/04/01-2020/03/31
国際共同研究加速基金(帰国発展研究) Representative RNA結合タンハ?クMSI2の限定分解によるか?ん幹細胞の運命制御機構 (2020年度分) 2020/04/01-2021/03/31
Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
分子遺伝学II Molecular Genetics II 前期 理学部 2020/04-2021/03
基盤生体分子薬学実習 Laboratory Practice in Basic Molecular Biology 通年不定 薬学研究科 2020/04-2021/03
基盤生体分子薬学実験 Research in Basic Molecular Biology 通年不定 薬学研究科 2020/04-2021/03
基盤生体分子薬学演習 Basic Molecular Biology Seminar 通年不定 薬学研究科 2020/04-2021/03
基盤生物化学実験技術 Basic Laboratory Techniques in Biological Chemistry 前期不定 薬学研究科 2020/04-2021/03
感染防御学II(免疫・ウイルス学)【H30以降入学者用】 Infection and Host Defense II (Immunology and Virology) 後期 薬学部 2020/04-2021/03
感染防御学1 Infection and Host Defense 1 前期 薬学部 2020/04-2021/03
感染防御学2 Infection and Host Defense 2 後期 薬学部 2020/04-2021/03
感染防御学I(微生物・ウイルス学)【H30以降入学者用】 Infection and Host Defense I (Microbiology and Virology) 前期 薬学部 2020/04-2021/03
特別実習(がん・幹細胞シグナル学) Research Training(Cell Fate Dynamics and Therapeutics) 通年 薬学部 2020/04-2021/03
薬学実験技術(連絡用) Basic Laboratory Techniques in Pharmaceutical Sciences 前期不定 薬学研究科 2020/04-2021/03
ILASセミナー:発生再生ゼミナール ILAS Seminar :Seminar on Developmental Biology and Regenerative Medicine 前期 全学共通科目 2021/04-2022/03
分子遺伝学II Molecular Genetics II 前期 理学部 2021/04-2022/03
創薬生命科学概論 Introduction to Modern Life Sciences for Drug Discovery 前期不定 薬学研究科 2021/04-2022/03
基盤生体分子薬学実習 Laboratory Practice in Basic Molecular Biology 通年不定 薬学研究科 2021/04-2022/03
基盤生体分子薬学実験 Research in Basic Molecular Biology 通年不定 薬学研究科 2021/04-2022/03
基盤生体分子薬学演習 Basic Molecular Biology Seminar 通年不定 薬学研究科 2021/04-2022/03
基盤生物化学実験技術 Basic Laboratory Techniques in Biological Chemistry 前期不定 薬学研究科 2021/04-2022/03
感染防御学I【H30以降入学者用】 Infection and Host Defense I 前期 薬学部 2021/04-2022/03
感染防御学II【H30以降入学者用】 Infection and Host Defense II 後期 薬学部 2021/04-2022/03
感染防御学1 Infection and Host Defense 1 前期 薬学部 2021/04-2022/03
感染防御学2 Infection and Host Defense 2 後期 薬学部 2021/04-2022/03
特別実習(がん・幹細胞シグナル学)【H30以降入学者用】 Research Training(Cell Fate Dynamics and Therapeutics) 通年 薬学部 2021/04-2022/03
特別実習(がん・幹細胞シグナル学) Research Training(Cell Fate Dynamics and Therapeutics) 通年 薬学部 2021/04-2022/03
薬学実験技術(連絡用) Basic Laboratory Techniques in Pharmaceutical Sciences 前期不定 薬学研究科 2021/04-2022/03
薬学専門実習IV 【H30以降入学者用】 Pharmaceutical Laboratory IV : Biochemistry and Microbiology 後期 薬学部 2021/04-2022/03
薬学専門実習4 Pharmaceutical Laboratory 4 : Biochemistry and Microbiology 後期 薬学部 2021/04-2022/03

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Faculty management (title, position)
Title Period
化学物質管理委員会 委員 2019/03/01-2020/03/
共同利用機器等委員会 委員 2020/04/-