新堂 啓祐

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Name(Kanji/Kana/Abecedarium Latinum)
新堂 啓祐/シンドウ ケイスケ/Shindou, Keisuke
Primary Affiliation(Org1/Job title)
Kyoto University Hospital Kyoto University Hospital/Program-Specific Assistant Professor, University Hospital
Personal Profile
(Japanese)
HIV-1のアクセサリー蛋白の一つであるVif(viral infectivity factor)と、Vifが対抗する宿主側の抗ウイルス因子であるAPOBEC3に関する研究をしている。
(English)
I have been researching on Vif (viral infectivity factor), one of the accessory proteins of HIV-1, and the host anti-viral protein APOBEC3, which is counteracted by Vif.
Language of Instruction
Language(japanese) Language(english) Code
日本語 Japanese jpn
ORCID ID
https://orcid.org/0000-0001-8793-8189
researchmap URL
https://researchmap.jp/7000009035
Research Topics
(Japanese)
HIV-1のアクセサリー遺伝子の一つであるViral infectivity factor (Vif)はウイルスの自然宿主であるT細胞やマクロファージでの複製に必須である。Vifは宿主のユビキチンリガーゼと複合体を形成し、宿主のウイルス抑制因子であるAPOBEC3ファミリー蛋白群をユビキチン化し、プロテアソーム分解を誘導することでウイルス複製に寄与している。Vifの機能の全貌を分子レベルで解明し、新たな治療法の開発に結び付けることを目標としている。
(English)
Viral infectivity factor (Vif), one of the accessary gene of HIV-1, is essential for the viral replication in the natural host T lymphocytes and macrophages. Vif forms a ubiquitin ligase complex with host proteins, and ubiquitinates and induces proteasomal degradation of APOBEC3 family proteins, the host anti-viral factors, leading to the viral replication. I would like to contribute to a novel therapeutics targeting Vif by elucidating all aspects of Vif functions.
Overview of the research
(Japanese)
VifはHIV-1の複製・伝播に必須のウイルス因子であり、治療標的である。Vifの機能発現に必須の補助因子としてCBF-betaを同定したが、VifとCBF-betaの相互作用も新規の治療標的となりうると考えられる。Vifの機能や細胞内制御の全貌を分子レベルで解明することで、Vifを標的とした新規治療薬の実現に貢献しようと考えている。
(English)
Vif is essential for HIV-1 replication and transmission, and a target for anti-HIV-1 therapeutics. I identified CBF-beta as an essential co-factor for Vif function, and the interaction between Vif and CBF-beta should be a novel target for HIV-1 therapeutics. I would like to contribute to a novel therapeutics targeting Vif by elucidating all aspects of Vif functions and intracellular regulations.
Fields of research (key words)
Key words(Japanese) Key words(English)
分子ウイルス学 Molecular Virology
分子生物学 Molecular Biology
生化学 Biochemistry
生物物理学 Biophysics
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Yusuke Matsui, Keisuke Shindo, Kayoko Nagata, Noriyoshi Yoshinaga, Kotaro Shirakawa, Masayuki Kobayashi, Akifumi Takaori-Kondo Matsui Y, Shindo K, Nagata K, Yoshinaga N, Shirakawa K, Kobayashi M, Takaori-Kondo A Yusuke Matsui, Keisuke Shindo, Kayoko Nagata, Noriyoshi Yoshinaga, Kotaro Shirakawa, Masayuki Kobayashi, Akifumi Takaori-Kondo Core Binding Factor beta Protects HIV, Type 1 Accessory Protein Viral Infectivity Factor from MDM2-mediated Degradation Core binding factor β protects HIV, type 1 accessory protein viral infectivity factor from MDM2-mediated degradation Core Binding Factor beta Protects HIV, Type 1 Accessory Protein Viral Infectivity Factor from MDM2-mediated Degradation JOURNAL OF BIOLOGICAL CHEMISTRY, 291, 48, 24892-24899 Journal of Biological Chemistry, 291, 48, 24892-24899 JOURNAL OF BIOLOGICAL CHEMISTRY, 291, 48, 24892-24899 2016/11 Refereed English Research paper(scientific journal) Disclose to all
Wataru Maruyama, Kotaro Shirakawa, Hiroyuki Matsui, Tadahiko Matsumoto, Hiroyuki Yamazaki, Anamaria D. Sarca, Yasuhiro Kazuma, Masayuki Kobayashi, Keisuke Shindo, Akifumi Takaori-Kondo Maruyama W, Shirakawa K, Matsui H, Matsumoto T, Yamazaki H, Sarca A.D, Kazuma Y, Kobayashi M, Shindo K, Takaori-Kondo A Wataru Maruyama, Kotaro Shirakawa, Hiroyuki Matsui, Tadahiko Matsumoto, Hiroyuki Yamazaki, Anamaria D. Sarca, Yasuhiro Kazuma, Masayuki Kobayashi, Keisuke Shindo, Akifumi Takaori-Kondo Classical NF-kB pathway is responsible for APOBEC3B expression in cancer cells Classical NF-κB pathway is responsible for APOBEC3B expression in cancer cells Classical NF-kB pathway is responsible for APOBEC3B expression in cancer cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 478, 3, 1466-1471 Biochemical and Biophysical Research Communications, 478, 3, 1466-1471 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 478, 3, 1466-1471 2016/09 Refereed English Research paper(scientific journal) Disclose to all
Kei Miyakawa, Satoko Matsunaga, Kazuhiko Kanou, Atsushi Matsuzawa, Ryo Morishita, Ayumi Kudoh, Keisuke Shindo, Masaru Yokoyama, Hironori Sato, Hirokazu Kimura, Tomohiko Tamura, Naoki Yamamoto, Hidenori Ichijo, Akifumi Takaori-Kondo, Akihide Ryo Kei Miyakawa, Satoko Matsunaga, Kazuhiko Kanou, Atsushi Matsuzawa, Ryo Morishita, Ayumi Kudoh, Keisuke Shindo, Masaru Yokoyama, Hironori Sato, Hirokazu Kimura, Tomohiko Tamura, Naoki Yamamoto, Hidenori Ichijo, Akifumi Takaori-Kondo, Akihide Ryo Kei Miyakawa, Satoko Matsunaga, Kazuhiko Kanou, Atsushi Matsuzawa, Ryo Morishita, Ayumi Kudoh, Keisuke Shindo, Masaru Yokoyama, Hironori Sato, Hirokazu Kimura, Tomohiko Tamura, Naoki Yamamoto, Hidenori Ichijo, Akifumi Takaori-Kondo, Akihide Ryo ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction NATURE COMMUNICATIONS, 6, 6945, 1-10 NATURE COMMUNICATIONS, 6, 6945, 1-10 NATURE COMMUNICATIONS, 6, 6945, 1-10 2015/04 Refereed English Research paper(scientific journal) Disclose to all
Tada K, Kobayashi M, Takiuchi Y, Iwai F, Sakamoto T, Nagata K, Shinohara M, Io K, Shirakawa K, Hishizawa M, Shindo K, Kadowaki N, Hirota K, Yamamoto J, Iwai S, Sasanuma H, Takeda S, Takaori-Kondo A Tada K, Kobayashi M, Takiuchi Y, Iwai F, Sakamoto T, Nagata K, Shinohara M, Io K, Shirakawa K, Hishizawa M, Shindo K, Kadowaki N, Hirota K, Yamamoto J, Iwai S, Sasanuma H, Takeda S, Takaori-Kondo A Tada K, Kobayashi M, Takiuchi Y, Iwai F, Sakamoto T, Nagata K, Shinohara M, Io K, Shirakawa K, Hishizawa M, Shindo K, Kadowaki N, Hirota K, Yamamoto J, Iwai S, Sasanuma H, Takeda S, Takaori-Kondo A Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia Science Advances, 1, e1400203, 1-13 , 1, e1400203, 1-13 Science Advances, 1, e1400203, 1-13 2015/04 Refereed English Research paper(scientific journal) Disclose to all
Masashi Matsui, Keisuke Shindo, Taisuke Izumi, Katsuhiro Io, Masanobu Shinohara, Jun Komano, Masayuki Kobayashi, Norimitsu Kadowaki, Reuben S. Harris, Akifumi Takaori-Kondo Masashi Matsui, Keisuke Shindo, Taisuke Izumi, Katsuhiro Io, Masanobu Shinohara, Jun Komano, Masayuki Kobayashi, Norimitsu Kadowaki, Reuben S. Harris, Akifumi Takaori-Kondo Masashi Matsui, Keisuke Shindo, Taisuke Izumi, Katsuhiro Io, Masanobu Shinohara, Jun Komano, Masayuki Kobayashi, Norimitsu Kadowaki, Reuben S. Harris, Akifumi Takaori-Kondo Small molecules that inhibit Vif-induced degradation of APOBEC3G Small molecules that inhibit Vif-induced degradation of APOBEC3G Small molecules that inhibit Vif-induced degradation of APOBEC3G VIROLOGY JOURNAL, 11, 1 VIROLOGY JOURNAL, 11, 1 VIROLOGY JOURNAL, 11, 1 2014/07 Refereed English Research paper(scientific journal) Disclose to all
Yusuke Matsui, Keisuke Shindo, Kayoko Nagata, Katsuhiro Lo, Kohei Tada, Fumie Iwai, Masayuki Kobayashi, Norimitsu Kadowaki, Reuben S. Harris, Akifumi Takaori-Kondo Matsui Y, Shindo K, Nagata K, Io K, Tada K, Iwai F, Kobayashi M, Kadowaki N, Harris R.S, Takaori-Kondo A Yusuke Matsui, Keisuke Shindo, Kayoko Nagata, Katsuhiro Lo, Kohei Tada, Fumie Iwai, Masayuki Kobayashi, Norimitsu Kadowaki, Reuben S. Harris, Akifumi Takaori-Kondo Defining HIV-1 Vif residues that interact with CBF beta by site-directed mutagenesis Defining HIV-1 Vif residues that interact with CBFβ by site-directed mutagenesis Defining HIV-1 Vif residues that interact with CBF beta by site-directed mutagenesis VIROLOGY, 449, 82-87 Virology, 449, 82-87 VIROLOGY, 449, 82-87 2014/01 Refereed English Research paper(scientific journal) Disclose to all
Takashi Sakamoto, Masayuki Kobayashi, Kohei Tada, Masanobu Shinohara, Katsuhiro Io, Kayoko Nagata, Fumie Iwai, Yoko Takiuchi, Yasuyuki Arai, Kouhei Yamashita, Keisuke Shindo, Norimitsu Kadowaki, Yoshio Koyanagi, Akifumi Takaori-Kondo Takashi Sakamoto, Masayuki Kobayashi, Kohei Tada, Masanobu Shinohara, Katsuhiro Io, Kayoko Nagata, Fumie Iwai, Yoko Takiuchi, Yasuyuki Arai, Kouhei Yamashita, Keisuke Shindo, Norimitsu Kadowaki, Yoshio Koyanagi, Akifumi Takaori-Kondo Takashi Sakamoto, Masayuki Kobayashi, Kohei Tada, Masanobu Shinohara, Katsuhiro Io, Kayoko Nagata, Fumie Iwai, Yoko Takiuchi, Yasuyuki Arai, Kouhei Yamashita, Keisuke Shindo, Norimitsu Kadowaki, Yoshio Koyanagi, Akifumi Takaori-Kondo CKIP-1 Is an Intrinsic Negative Regulator of T-Cell Activation through an Interaction with CARMA1 CKIP-1 Is an Intrinsic Negative Regulator of T-Cell Activation through an Interaction with CARMA1 CKIP-1 Is an Intrinsic Negative Regulator of T-Cell Activation through an Interaction with CARMA1 PLOS ONE, 9, 1 PLOS ONE, 9, 1 PLOS ONE, 9, 1 2014/01 Refereed English Research paper(scientific journal) Disclose to all
Akifumi Takaori-Kondo, Keisuke Shindo Akifumi Takaori-Kondo, Keisuke Shindo Akifumi Takaori-Kondo, Keisuke Shindo HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors FRONTIERS IN MICROBIOLOGY, 4, FEB FRONTIERS IN MICROBIOLOGY, 4, FEB FRONTIERS IN MICROBIOLOGY, 4, FEB 2013/02 Refereed English Disclose to all
Masanobu Shinohara, Katsuhiro Io, Keisuke Shindo, Masashi Matsui, Takashi Sakamoto, Kohei Tada, Masayuki Kobayashi, Norimitsu Kadowaki, Akifumi Takaori-Kondo Masanobu Shinohara, Katsuhiro Io, Keisuke Shindo, Masashi Matsui, Takashi Sakamoto, Kohei Tada, Masayuki Kobayashi, Norimitsu Kadowaki, Akifumi Takaori-Kondo Masanobu Shinohara, Katsuhiro Io, Keisuke Shindo, Masashi Matsui, Takashi Sakamoto, Kohei Tada, Masayuki Kobayashi, Norimitsu Kadowaki, Akifumi Takaori-Kondo APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells SCIENTIFIC REPORTS, 2 SCIENTIFIC REPORTS, 2 SCIENTIFIC REPORTS, 2 2012/11 Refereed English Research paper(scientific journal) Disclose to all
Keisuke Shindo, Ming Li, Phillip J. Gross, William L. Brown, Elena Harjes, Yongjian Lu, Hiroshi Matsuo, Reuben S. Harris Keisuke Shindo, Ming Li, Phillip J. Gross, William L. Brown, Elena Harjes, Yongjian Lu, Hiroshi Matsuo, Reuben S. Harris Keisuke Shindo, Ming Li, Phillip J. Gross, William L. Brown, Elena Harjes, Yongjian Lu, Hiroshi Matsuo, Reuben S. Harris A comparison of two single-stranded DNA binding models by mutational analysis of APOBEC3G A comparison of two single-stranded DNA binding models by mutational analysis of APOBEC3G A comparison of two single-stranded DNA binding models by mutational analysis of APOBEC3G Biology, 1, 2, 260-276 Biology, 1, 2, 260-276 Biology, 1, 2, 260-276 2012/08/02 Refereed English Research paper(scientific journal) Disclose to all
Stefanie Jaeger, Dong Young Kim, Judd F. Hultquist, Keisuke Shindo, Rebecca S. LaRue, Eunju Kwon, Ming Li, Brett D. Anderson, Linda Yen, David Stanley, Cathal Mahon, Joshua Kane, Kathy Franks-Skiba, Peter Cimermancic, Alma Burlingame, Andrej Sali, Charles S. Craik, Reuben S. Harris, John D. Gross, Nevan J. Krogan J{\"a}ger S, Kim D.Y, Hultquist J.F, Shindo K, Larue R.S, Kwon E, Li M, Anderson B.D, Yen L, Stanley D, Mahon C, Kane J, Franks-Skiba K, Cimermancic P, Burlingame A, Sali A, Craik C.S, Harris R.S, Gross J.D, Krogan N.J Stefanie Jaeger, Dong Young Kim, Judd F. Hultquist, Keisuke Shindo, Rebecca S. LaRue, Eunju Kwon, Ming Li, Brett D. Anderson, Linda Yen, David Stanley, Cathal Mahon, Joshua Kane, Kathy Franks-Skiba, Peter Cimermancic, Alma Burlingame, Andrej Sali, Charles S. Craik, Reuben S. Harris, John D. Gross, Nevan J. Krogan Vif hijacks CBF-beta to degrade APOBEC3G and promote HIV-1 infection Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection Vif hijacks CBF-beta to degrade APOBEC3G and promote HIV-1 infection NATURE, 481, 7381, 371-375 Nature, 481, 7381, 371-375 NATURE, 481, 7381, 371-375 2012/01 Refereed English Research paper(scientific journal) Disclose to all
John S. Albin, Rebecca S. LaRue, Jessalyn A. Weaver, William L. Brown, Keisuke Shindo, Elena Harjes, Hiroshi Matsuo, Reuben S. Harris John S. Albin, Rebecca S. LaRue, Jessalyn A. Weaver, William L. Brown, Keisuke Shindo, Elena Harjes, Hiroshi Matsuo, Reuben S. Harris John S. Albin, Rebecca S. LaRue, Jessalyn A. Weaver, William L. Brown, Keisuke Shindo, Elena Harjes, Hiroshi Matsuo, Reuben S. Harris A Single Amino Acid in Human APOBEC3F Alters Susceptibility to HIV-1 Vif A Single Amino Acid in Human APOBEC3F Alters Susceptibility to HIV-1 Vif A Single Amino Acid in Human APOBEC3F Alters Susceptibility to HIV-1 Vif JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 52, 40785-40792 JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 52, 40785-40792 JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 52, 40785-40792 2010/12 Refereed English Research paper(scientific journal) Disclose to all
Eric W. Refsland, Mark D. Stenglein, Keisuke Shindo, John S. Albin, William L. Brown, Reuben S. Harris Eric W. Refsland, Mark D. Stenglein, Keisuke Shindo, John S. Albin, William L. Brown, Reuben S. Harris Eric W. Refsland, Mark D. Stenglein, Keisuke Shindo, John S. Albin, William L. Brown, Reuben S. Harris Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction NUCLEIC ACIDS RESEARCH, 38, 13, 4274-4284 NUCLEIC ACIDS RESEARCH, 38, 13, 4274-4284 NUCLEIC ACIDS RESEARCH, 38, 13, 4274-4284 2010/07 Refereed English Research paper(scientific journal) Disclose to all
Shivender M. D. Shandilya, Madhavi N. L. Nalam, Ellen A. Nalivaika, Phillip J. Gross, Johnathan C. Valesano, Keisuke Shindo, Ming Li, Mary Munson, William E. Royer, Elena Harjes, Takahide Kono, Hiroshi Matsuo, Reuben S. Harris, Mohan Somasundaran, Celia A. Schiffer Shivender M. D. Shandilya, Madhavi N. L. Nalam, Ellen A. Nalivaika, Phillip J. Gross, Johnathan C. Valesano, Keisuke Shindo, Ming Li, Mary Munson, William E. Royer, Elena Harjes, Takahide Kono, Hiroshi Matsuo, Reuben S. Harris, Mohan Somasundaran, Celia A. Schiffer Shivender M. D. Shandilya, Madhavi N. L. Nalam, Ellen A. Nalivaika, Phillip J. Gross, Johnathan C. Valesano, Keisuke Shindo, Ming Li, Mary Munson, William E. Royer, Elena Harjes, Takahide Kono, Hiroshi Matsuo, Reuben S. Harris, Mohan Somasundaran, Celia A. Schiffer Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces STRUCTURE, 18, 1, 28-38 STRUCTURE, 18, 1, 28-38 STRUCTURE, 18, 1, 28-38 2010/01 Refereed English Research paper(scientific journal) Disclose to all
Elena Harjes, Phillip J. Gross, Kuan-Ming Chen, Yongjian Lu, Keisuke Shindo, Roni Nowarski, John D. Gross, Moshe Kotler, Reuben S. Harris, Hiroshi Matsuo Elena Harjes, Phillip J. Gross, Kuan-Ming Chen, Yongjian Lu, Keisuke Shindo, Roni Nowarski, John D. Gross, Moshe Kotler, Reuben S. Harris, Hiroshi Matsuo Elena Harjes, Phillip J. Gross, Kuan-Ming Chen, Yongjian Lu, Keisuke Shindo, Roni Nowarski, John D. Gross, Moshe Kotler, Reuben S. Harris, Hiroshi Matsuo An Extended Structure of the APOBEC3G Catalytic Domain Suggests a Unique Holoenzyme Model An Extended Structure of the APOBEC3G Catalytic Domain Suggests a Unique Holoenzyme Model An Extended Structure of the APOBEC3G Catalytic Domain Suggests a Unique Holoenzyme Model JOURNAL OF MOLECULAR BIOLOGY, 389, 5, 819-832 JOURNAL OF MOLECULAR BIOLOGY, 389, 5, 819-832 JOURNAL OF MOLECULAR BIOLOGY, 389, 5, 819-832 2009/06 Refereed English Research paper(scientific journal) Disclose to all
Guylaine Hache, Keisuke Shindo, John S. Albin, Reuben S. Harris Guylaine Hache, Keisuke Shindo, John S. Albin, Reuben S. Harris Guylaine Hache, Keisuke Shindo, John S. Albin, Reuben S. Harris Evolution of HIV-1 isolates that use a novel Vif-independent mechanism to resist restriction by human APOBEC3G Evolution of HIV-1 isolates that use a novel Vif-independent mechanism to resist restriction by human APOBEC3G Evolution of HIV-1 isolates that use a novel Vif-independent mechanism to resist restriction by human APOBEC3G CURRENT BIOLOGY, 18, 11, 819-824 CURRENT BIOLOGY, 18, 11, 819-824 CURRENT BIOLOGY, 18, 11, 819-824 2008/06 Refereed English Research paper(scientific journal) Disclose to all
Kuan-Ming Chen, Elena Harjes, Phillip J. Gross, Amr Fahmy, Yongjian Lu, Keisuke Shindo, Reuben S. Harris, Hiroshi Matsuo Kuan-Ming Chen, Elena Harjes, Phillip J. Gross, Amr Fahmy, Yongjian Lu, Keisuke Shindo, Reuben S. Harris, Hiroshi Matsuo Kuan-Ming Chen, Elena Harjes, Phillip J. Gross, Amr Fahmy, Yongjian Lu, Keisuke Shindo, Reuben S. Harris, Hiroshi Matsuo Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G NATURE, 452, 7183, 116-U16 NATURE, 452, 7183, 116-U16 NATURE, 452, 7183, 116-U16 2008/03 Refereed English Research paper(scientific journal) Disclose to all
Kuan-Ming Chen, Natalia Martemyanova, Yongjian Lu, Keisuke Shindo, Hiroshi Matsuo, Reuben S. Harris Kuan-Ming Chen, Natalia Martemyanova, Yongjian Lu, Keisuke Shindo, Hiroshi Matsuo, Reuben S. Harris Kuan-Ming Chen, Natalia Martemyanova, Yongjian Lu, Keisuke Shindo, Hiroshi Matsuo, Reuben S. Harris Extensive mutagenesis experiments corroborate a structural model for the DNA deaminase domain of APOBEC3G Extensive mutagenesis experiments corroborate a structural model for the DNA deaminase domain of APOBEC3G Extensive mutagenesis experiments corroborate a structural model for the DNA deaminase domain of APOBEC3G FEBS LETTERS, 581, 24, 4761-4766 FEBS LETTERS, 581, 24, 4761-4766 FEBS LETTERS, 581, 24, 4761-4766 2007/10 Refereed English Research paper(scientific journal) Disclose to all
M Kobayashi, A Takaori-Kondo, K Shindo, A Abudu, K Fukunaga, T Uchiyama M Kobayashi, A Takaori-Kondo, K Shindo, A Abudu, K Fukunaga, T Uchiyama M Kobayashi, A Takaori-Kondo, K Shindo, A Abudu, K Fukunaga, T Uchiyama APOBEC3G targets specific virus species APOBEC3G targets specific virus species APOBEC3G targets specific virus species JOURNAL OF VIROLOGY, 78, 15, 8238-8244 JOURNAL OF VIROLOGY, 78, 15, 8238-8244 JOURNAL OF VIROLOGY, 78, 15, 8238-8244 2004/08 Refereed English Research paper(scientific journal) Disclose to all
K Shindo, A Takaori-Kondo, M Kobayashi, A Abudu, K Fukunaga, T Uchiyama K Shindo, A Takaori-Kondo, M Kobayashi, A Abudu, K Fukunaga, T Uchiyama K Shindo, A Takaori-Kondo, M Kobayashi, A Abudu, K Fukunaga, T Uchiyama The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 45, 44412-44416 JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 45, 44412-44416 JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 45, 44412-44416 2003/11 Refereed English Research paper(scientific journal) Disclose to all
M Kobayashi, A Takaori-Kondo, K Shindo, C Mizutani, T Ishikawa, T Uchiyama M Kobayashi, A Takaori-Kondo, K Shindo, C Mizutani, T Ishikawa, T Uchiyama M Kobayashi, A Takaori-Kondo, K Shindo, C Mizutani, T Ishikawa, T Uchiyama Successful treatment with paclitaxel of advanced AIDS-associated Kaposi's sarcoma Successful treatment with paclitaxel of advanced AIDS-associated Kaposi's sarcoma Successful treatment with paclitaxel of advanced AIDS-associated Kaposi's sarcoma INTERNAL MEDICINE, 41, 12, 1209-1212 INTERNAL MEDICINE, 41, 12, 1209-1212 INTERNAL MEDICINE, 41, 12, 1209-1212 2002/12 Refereed English Research paper(scientific journal) Disclose to all
M Kobayashi, A Takaori-Kondo, K Shindo, C Mizutani, T Ishikawa, T Uchiyama M Kobayashi, A Takaori-Kondo, K Shindo, C Mizutani, T Ishikawa, T Uchiyama M Kobayashi, A Takaori-Kondo, K Shindo, C Mizutani, T Ishikawa, T Uchiyama Successful treatment with paclitaxel of advanced AIDS-associated Kaposi's sarcoma Successful treatment with paclitaxel of advanced AIDS-associated Kaposi's sarcoma Successful treatment with paclitaxel of advanced AIDS-associated Kaposi's sarcoma INTERNAL MEDICINE, 41, 12, 1209-1212 INTERNAL MEDICINE, 41, 12, 1209-1212 INTERNAL MEDICINE, 41, 12, 1209-1212 2002/12 Refereed English Research paper(scientific journal) Disclose to all
Y Ezumi, K Shindoh, M Tsuji, H Takayama Y Ezumi, K Shindoh, M Tsuji, H Takayama Y Ezumi, K Shindoh, M Tsuji, H Takayama Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human platelets Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human platelets Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human platelets JOURNAL OF EXPERIMENTAL MEDICINE, 188, 2, 267-276 JOURNAL OF EXPERIMENTAL MEDICINE, 188, 2, 267-276 JOURNAL OF EXPERIMENTAL MEDICINE, 188, 2, 267-276 1998/07 Refereed English Research paper(scientific journal) Disclose to all

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External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
基盤C Representative HIV-1 Vifの細胞内調節機構および機能発現機構の解明 2016/04/01-2019/03/31
基盤研究(C) Representative HIV-1 Vifの細胞内調節機構および機能発現機構の解明 (平成29年度分) 2017/04/01-2018/03/31
基盤研究(C) Representative HIV-1 Vifの細胞内調節機構および機能発現機構の解明 (平成30年度分) 2018/04/01-2019/03/31
基盤研究(C) Representative HIV-1 Vifの細胞内調節機構および機能発現機構の解明 (2019年度分) 2019/04/01-2020/03/31
External funds: other than those above
System Main person Title(Japanese) Title(English) Period
A-STEP 新堂啓祐 HIV-1 Vifを標的とした新しい抗ウイルス薬の開発 2012/11/01-2013/10/31
ヴィーブヘルスケア研究助成 新堂啓祐 HIV-1の感染・複製に関与するDNA修復因子の探索 2014/11/01-2016/03/31
DSKプロジェクト 公募グラント 高折晃史 シチジン脱アミノ化酵素APOBEC3Bによる遺伝子変異導入がヒト悪性疾患の発生・進展に及ぼす影響の検討 2013/11/01-2015/10/31
探索医療センター 研究助成 新堂 啓祐 HIV-1Vifと抗HIV-1宿主因子APOBEC3Gの相互作用を標的とした新規抗ウイルス薬の開発 2011/10/01-2011/03/31