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Nomura, Norimichi

Graduate School of Medicine, Medicine Associate Professor

Nomura, Norimichi
list
    Last Updated :2024/03/21

    Basic Information

    Faculty

    • 医学部

    Professional Memberships

    • 日本生化学会
    • 日本結晶学会

    Academic Degree

    • Ph.D. (Agriculture)(Kyoto University)
    • Master (Agriculture)(Kyoto University)

    Academic Resume (Graduate Schools)

    • Kyoto University, Graduate School of Agriculture, Department of Fisheries, 修了
    • Kyoto University, Graduate School of Agriculture, Department of Fisheries, 修了

    Academic Resume (Undergraduate School/Majors)

    • Kyoto University, Faculty of Agriculture, Department of Fisheries, 卒業

    High School

    • High School

      土佐高等学校

    Research History

    • From Apr. 2019, To Present
      Kyoto University, Graduate School of Medicine, 准教授
    • From Jun. 2009, To Mar. 2019
      Kyoto University, Graduate School of Medicine, 助教
    • From Jan. 2008, To Mar. 2011
      科学技術振興機構, ERATO岩田ヒト膜受容体構造プロジェクト, グループリーダー
    • From Oct. 2006, To Dec. 2007
      科学技術振興機構, ERATO岩田ヒト膜受容体構造プロジェクト, 研究員
    • From Jul. 1999, To Sep. 2006
      Kyoto University, Graduate School of Agriculture, 助手
    • From Sep. 2005, To Aug. 2006
      Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Barry Stoddard Lab, 客員研究員
    • From Apr. 1998, To Jun. 1999
      日本学術振興会, 特別研究員(PD)
    • From Apr. 1995, To Mar. 1998
      日本学術振興会, 特別研究員(DC1)

    Language of Instruction

    • Japanese
    • English

    ID,URL

    Website(s) (URL(s))

    researchmap URL

    list
      Last Updated :2024/03/21

      Research

      Research Topics, Overview of the research

      • Research Topics

        Structural biology of membrane proteins
      • Overview of the research

        Structural biology can provide a coherent picture of medically relevant phenomena such as regulation of homeostasis and pathogenesis. My interest is focusing to determine structures of membrane proteins associated with human diseases by cryo-EM single particle analysis and X-ray crystallography. An increasing emphasis is placed on computational approaches to rational design and screening of novel pharmacologically active compounds as well as molecular dynamics simulation. My goals include developing a comprehensive understanding of life at the atomic and molecular level and extending this knowledge to elucidate basic principles for modulation of cellular functions with therapeutic benefits.

      Research Interests

      • がん免疫
      • 膜タンパク質
      • トランスポーター
      • 抗体医薬
      • 抗体
      • 分子間相互作用
      • 人工タンパク質分子設計
      • X線結晶構造解析
      • ウイルス侵入受容体
      • 構造生物学
      • クライオ電子顕微鏡単粒子解析
      • タンパク質工学
      • 立体構造に基づく創薬

      Research Areas

      • Life sciences, Tumor biology
      • Life sciences, Virology
      • Life sciences, Molecular biology
      • Life sciences, Structural biochemistry
      • Nanotechnology/Materials, Molecular biochemistry
      • Life sciences, Medical biochemistry

      Papers

      • 人生100年時代の「老い」を考える スペルミジンは脂肪酸酸化を直接活性化し、老化個体における抗腫瘍免疫を回復させる
        本庶 佑; Al Habsi Muna; 茶本 健司; 松本 健; 野村 紀通; Wu Yibo; Zhang Baihao; 仲島 由佳; 園村 和弘; Menzies Rosemary; 杉浦 悠毅; 野村 弥生; 松田 文彦; 岩田 想; 小椋 利彦; Fagarasan Sidonia
        日本生化学会大会プログラム・講演要旨集, Nov. 2021
      • Structural basis of hepatitis B virus receptor binding
        Jinta Asami, Jae-Hyun Park, Yayoi Nomura, Chisa Kobayashi, Junki Mifune, Naito Ishimoto, Tomoko Uemura, Kehong Liu, Yumi Sato, Zhikuan Zhang, Masamichi Muramatsu, Takaji Wakita, David Drew, So Iwata, Toshiyuki Shimizu, Koichi Watashi, Sam-Yong Park, Norimichi Nomura, Umeharu Ohto
        Nature Structural & Molecular Biology, 17 Jan. 2024, Peer-reviewed, Corresponding author
      • Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn2+ uptake into the Golgi apparatus
        Han Ba Bui, Satoshi Watanabe, Norimichi Nomura, Kehong Liu, Tomoko Uemura, Michio Inoue, Akihisa Tsutsumi, Hiroyuki Fujita, Kengo Kinoshita, Yukinari Kato, So Iwata, Masahide Kikkawa, Kenji Inaba
        Nature Communications, Aug. 2023, Peer-reviewed
      • Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota
        Titouan Jaunet-Lahary, Tatsuro Shimamura, Masahiro Hayashi, Norimichi Nomura, Kouta Hirasawa, Tetsuya Shimizu, Masao Yamashita, Naotaka Tsutsumi, Yuta Suehiro, Keiichi Kojima, Yuki Sudo, Takashi Tamura, Hiroko Iwanari, Takao Hamakubo, So Iwata, Kei-ichi Okazaki, Teruhisa Hirai, Atsuko Yamashita
        Nature Communications, 03 Apr. 2023, Peer-reviewed
      • Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice
        Muna Al-Habsi, Kenji Chamoto, Ken Matsumoto, Norimichi Nomura, Baihao Zhang, Yuki Sugiura, Kazuhiro Sonomura, Aprilia Maharani, Yuka Nakajima, Yibo Wu, Yayoi Nomura, Rosemary Menzies, Masaki Tajima, Koji Kitaoka, Yasuharu Haku, Sara Delghandi, Keiko Yurimoto, Fumihiko Matsuda, So Iwata, Toshihiko Ogura, Sidonia Fagarasan, Tasuku Honjo
        Science, 27 Oct. 2022, Peer-reviewed, Lead author
      • Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex
        Ryoji Suno, Yukihiko Sugita, Kazushi Morimoto, Hiroko Takazaki, Hirokazu Tsujimoto, Mika Hirose, Chiyo Suno-Ikeda, Norimichi Nomura, Tomoya Hino, Asuka Inoue, Kenji Iwasaki, Takayuki Kato, So Iwata, Takuya Kobayashi
        Cell Reports, 13 Sep. 2022, Peer-reviewed
      • Structure of SARS-CoV-2 membrane protein essential for virus assembly
        Zhikuan Zhang, Norimichi Nomura, Yukiko Muramoto, Toru Ekimoto, Tomoko Uemura, Kehong Liu, Moeko Yui, Nozomu Kono, Junken Aoki, Mitsunori Ikeguchi, Takeshi Noda, So Iwata, Umeharu Ohto, Toshiyuki Shimizu
        Nature Communications, 05 Aug. 2022, Peer-reviewed
      • Structure of the bile acid transporter and HBV receptor NTCP
        Jinta Asami, Kanako Terakado Kimura, Yoko Fujita-Fujiharu, Hanako Ishida, Zhikuan Zhang, Yayoi Nomura, Kehong Liu, Tomoko Uemura, Yumi Sato, Masatsugu Ono, Masaki Yamamoto, Takeshi Noda, Hideki Shigematsu, David Drew, So Iwata, Toshiyuki Shimizu, Norimichi Nomura, Umeharu Ohto
        Nature, 17 May 2022, Peer-reviewed, Corresponding author
      • Structural insights into the HBV receptor and bile acid transporter NTCP
        Jae-Hyun Park, Masashi Iwamoto, Ji-Hye Yun, Tomomi Uchikubo-Kamo, Donghwan Son, Zeyu Jin, Hisashi Yoshida, Mio Ohki, Naito Ishimoto, Kenji Mizutani, Mizuki Oshima, Masamichi Muramatsu, Takaji Wakita, Mikako Shirouzu, Kehong Liu, Tomoko Uemura, Norimichi Nomura, So Iwata, Koichi Watashi, Jeremy R. H. Tame, Tomohiro Nishizawa, Weontae Lee, Sam-Yong Park
        Nature, 17 May 2022, Peer-reviewed
      • Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2
        Rei Matsuoka; Roman Fudim; Sukkyeong Jung; Chenou Zhang; Andre Bazzone; Yurie Chatzikyriakidou; Carol V. Robinson; Norimichi Nomura; So Iwata; Michael Landreh; Laura Orellana; Oliver Beckstein; David Drew
        Nature Structural & Molecular Biology, 17 Feb. 2022, Peer-reviewed
      • Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine
        Koichiro E. Kishi, Yoon Seok Kim, Masahiro Fukuda, Masatoshi Inoue, Tsukasa Kusakizako, Peter Y. Wang, Charu Ramakrishnan, Eamon F.X. Byrne, Elina Thadhani, Joseph M. Paggi, Toshiki E. Matsui, Keitaro Yamashita, Takashi Nagata, Masae Konno, Sean Quirin, Maisie Lo, Tyler Benster, Tomoko Uemura, Kehong Liu, Mikihiro Shibata, Norimichi Nomura, So Iwata, Osamu Nureki, Ron O. Dror, Keiichi Inoue, Karl Deisseroth, Hideaki E. Kato
        Cell, 02 Feb. 2022, Peer-reviewed
      • Molecular mechanism of SbmA, a promiscuous transporter exploited by antimicrobial peptides
        Dmitry Ghilarov, Satomi Inaba-Inoue, Piotr Stepien, Feng Qu, Elizabeth Michalczyk, Zuzanna Pakosz, Norimichi Nomura, Satoshi Ogasawara, Graham Charles Walker, Sylvie Rebuffat, So Iwata, Jonathan Gardiner Heddle, Konstantinos Beis
        Science Advances, 09 Sep. 2021, Peer-reviewed
      • The structural basis of bacterial manganese import
        Stephanie L. Neville; Jennie Sjöhamn; Jacinta A. Watts; Hugo MacDermott-Opeskin; Stephen J. Fairweather; Katherine Ganio; Alex Carey Hulyer; Aaron P. McGrath; Andrew J. Hayes; Tess R. Malcolm; Mark R. Davies; Norimichi Nomura; So Iwata; Megan L. O’Mara; Megan J. Maher; Christopher A. McDevitt
        Science Advances, 06 Aug. 2021, Peer-reviewed
      • Cryo-EM structure of the human MT1–Gi signaling complex
        Hiroyuki H. Okamoto, Hirotake Miyauchi, Asuka Inoue, Francesco Raimondi, Hirokazu Tsujimoto, Tsukasa Kusakizako, Wataru Shihoya, Keitaro Yamashita, Ryoji Suno, Norimichi Nomura, Takuya Kobayashi, So Iwata, Tomohiro Nishizawa, Osamu Nureki
        Nature Structural & Molecular Biology, 05 Aug. 2021, Peer-reviewed
      • The structure of MgtE in the absence of magnesium provides new insights into channel gating.
        Jin F, Sun M, Fujii T, Yamada Y, Wang J, Maturana AD, Wada M, Su S, Ma J, Takeda H, Kusakizako T, Tomita A, Nakada-Nakura Y, Liu K, Uemura T, Nomura Y, Nomura N, Ito K, Nureki O, Namba K, Iwata S, Yu Y, Hattori M.
        PLoS Biology, Apr. 2021, Peer-reviewed
      • Cryo-EM structure of the prostaglandin E receptor EP4 coupled to G protein
        Shingo Nojima, Yoko Fujita, Kanako Terakado Kimura, Norimichi Nomura, Ryoji Suno, Kazushi Morimoto, Masaki Yamamoto, Takeshi Noda, So Iwata, Hideki Shigematsu, Takuya Kobayashi
        Structure, Mar. 2021, Peer-reviewed
      • Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone
        Dohyun Im, Asuka Inoue, Takaaki Fujiwara, Takanori Nakane, Yasuaki Yamanaka, Tomoko Uemura, Chihiro Mori, Yuki Shiimura, Kanako Terakado Kimura, Hidetsugu Asada, Norimichi Nomura, Tomoyuki Tanaka, Ayumi Yamashita, Eriko Nango, Kensuke Tono, Francois Marie Ngako Kadji, Junken Aoki, So Iwata, Tatsuro Shimamura
        Nature Communications, Dec. 2020, Peer-reviewed
      • Isolation and thermal stabilization of mouse ferroportin
        Chandrika N Deshpande; Corbin R. Azucenas; Bo Qiao; Norimichi Nomura; Vicky Xin; Josep Font; So Iwata; Tomas Ganz; Elizabeta Nemeth; Bryan Mackenzie; Mika Jormakka
        FEBS Open Bio, 15 Nov. 2020, Peer-reviewed
      • Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion
        Kazuaki Matoba, Tetsuya Kotani, Akihisa Tsutsumi, Takuma Tsuji, Takaharu Mori, Daisuke Noshiro, Yuji Sugita, Norimichi Nomura, So Iwata, Yoshinori Ohsumi, Toyoshi Fujimoto, Hitoshi Nakatogawa, Masahide Kikkawa, Nobuo N. Noda
        Nature Structural & Molecular Biology, 26 Oct. 2020, Peer-reviewed
      • Structural insights into tetraspanin CD9 function
        Rie Umeda, Yuhkoh Satouh, Mizuki Takemoto, Yoshiko Nakada-Nakura, Kehong Liu, Takeshi Yokoyama, Mikako Shirouzu, So Iwata, Norimichi Nomura, Ken Sato, Masahito Ikawa, Tomohiro Nishizawa, Osamu Nureki
        Nature Communications, 30 Mar. 2020, Peer-reviewed
      • The crystal structure of angiotensin II type 2 receptor with endogenous peptide hormone
        Hidetsugu Asada, Asuka Inoue, Francois Marie Ngako Kadji, Kunio Hirata, Yuki Shiimura, Dohyun Im, Tatsuro Shimamura, Norimichi Nomura, Hiroko Iwanari, Takao Hamakubo, Osamu Kusano-Arai, Hiromi Hisano, Tomoko Uemura, Chiyo Suno, Junken Aoki, So Iwata
        Structure, Dec. 2019, Peer-reviewed
      • FRET-assisted photoactivation of flavoproteins for in vivo two-photon optogenetics
        Kinjo T; Terai K; Horita S; Nomura N; Sumiyama K; Togashi K; Iwata S; Matsuda M
        Nature Methods, Oct. 2019, Peer-reviewed
      • Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine
        Kanako Terakado Kimura, Hidetsugu Asada, Asuka Inoue, Francois Marie Ngako Kadji, Dohyun Im, Chihiro Mori, Takatoshi Arakawa, Kunio Hirata, Yayoi Nomura, Norimichi Nomura, Junken Aoki, So Iwata, Tatsuro Shimamura
        Nature Structural & Molecular Biology, Feb. 2019, Peer-reviewed
      • Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface
        Y. Toyoda, K. Morimoto, R. Suno, S. Horita, K. Yamashita, K. Hirata, Y. Sekiguchi, S. Yasuda, M. Shiroishi, T. Shimizu, Y. Urushibata, Y. Kajiwara, T. Inazumi, Y. Hotta, H. Asada, T. Nakane, Y. Shiimura, T. Nakagita, K. Tsuge, S. Yoshida, T. Kuribara, T. Hosoya, Y. Sugimoto, N. Nomura, M. Sato, T. Hirokawa, M. Kinoshita, T. Murata, K. Takayama, M. Yamamoto, S. Narumiya, S. Iwata, T. Kobayashi
        Nature Chemical Biology, Jan. 2019, Peer-reviewed
      • Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insights into switching mechanism
        Nagarathinam K; Nakada-Nakura Y; Parthier C; Terada T; Juge N; Jaenecke F; Liu K; Hotta Y; Miyaji T; Omote H; Iwata S; Nomura N; Stubbs M; Tanabe M
        Nature Communications, Oct. 2018, Peer-reviewed
      • Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog
        Asada H; Horita S; Hirata K; Shiroishi M; Shiimura Y; Iwanari H; Hamakubo T; Shimamura T; Nomura N; Kusano-Arai O; Uemura T; Suno C; Kobayashi T; Iwata S
        Nature Structural and Molecular Biology, Jul. 2018, Peer-reviewed
      • Structural basis for tumor necrosis factor blockade with the therapeutic antibody golimumab
        Masatsugu Ono; Shoichiro Horita; Yumi Sato; Yayoi Nomura; So Iwata; Norimichi Nomura
        Protein Science, 01 Jun. 2018, Peer-reviewed, Last author, Corresponding author
      • Mechanistic insights from conformational ensembles of the mammalian fructose transporter GLUT5
        Norimichi Nomura, So Iwata, David Drew
        SPring-8/SACLA Research Frontiers 2016, Aug. 2017, Invited, Lead author, Corresponding author
      • The multidrug-resistance transporter MdfA from Escherichia coli: crystallization and X-ray diffraction analysis
        Kumar Nagarathinam, Frank Jaenecke, Yoshiko Nakada-Nakura, Yunhon Hotta, Kehong Liu, So Iwata, Milton T. Stubbs, Norimichi Nomura, Mikio Tanabe
        Acta Crystallographica Section F-Structural Biology Communications, Jul. 2017, Peer-reviewed
      • The intervening removable affinity tag (iRAT) production system facilitates Fv antibody fragment-mediated crystallography
        Yayoi Nomura, Yumi Sato, Ryoji Suno, Shoichiro Horita, So Iwata, Norimichi Nomura
        Protein Science, Dec. 2016, Peer-reviewed, Last author, Corresponding author
      • High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1
        Shoichiro Horita, Yayoi Nomura, Yumi Sato, Tatsuro Shimamura, So Iwata, Norimichi Nomura
        Scientific Reports, Oct. 2016, Peer-reviewed, Last author, Corresponding author
      • 哺乳類フルクトース輸送体GLUT5の構造と分子機構
        野村紀通; 岩田想
        日本結晶学会誌, Jun. 2016, Invited
      • Structure and mechanism of the mammalian fructose transporter GLUT5
        Norimichi Nomura; Gregory Verdon, Hae Joo Kang, Tatsuro Shimamura, Yayoi Nomura, Yo Sonoda, Saba Abdul Hussien, Aziz Abdul Qureshi, Mathieu Coincon, Yumi Sato, Hitomi Abe, Yoshiko Nakada-Nakura, Tomoya Hino, Takatoshi Arakawa, Osamu Kusano-Arai, Hiroko Iwanari, Takeshi Murata, Takuya Kobayashi, Takao Hamakubo, Michihiro Kasahara, So Iwata, David Drew
        Nature, Oct. 2015, Peer-reviewed, Lead author, Corresponding author
      • Proteoliposome-based selection of a recombinant antibody fragment against the human M2 muscarinic acetylcholine receptor
        Suharni, Yayoi Nomura, Takatoshi Arakawa, Tomoya Hino, Hitomi Abe, Yoshiko Nakada-Nakura, Yumi Sato, Hiroko Iwanari, Mitsunori Shiroishi, Hidetsugu Asada, Tatsuro Shimamura, Takeshi Murata, Takuya Kobayashi, Takao Hamakubo, So Iwata, Norimichi Nomura
        Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, Dec. 2014, Peer-reviewed, Last author, Corresponding author
      • Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae
        Mitsunori Shiroishi; Hirokazu Tsujimoto; Hisayoshi Makyio; Hidetsugu Asada; Takami Yurugi-Kobayashi; Tatsuro Shimamura; Takeshi Murata; Norimichi Nomura; Tatsuya Haga; So Iwata; Takuya Kobayashi
        MICROBIAL CELL FACTORIES, Jun. 2012, Peer-reviewed
      • G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
        Tomoya Hino, Takatoshi Arakawa, Hiroko Iwanari, Takami Yurugi-Kobayashi, Chiyo Ikeda-Suno, Yoshiko Nakada-Nakura, Osamu Kusano-Arai, Simone Weyand, Tatsuro Shimamura, Norimichi Nomura, Alexander D. Cameron, Takuya Kobayashi, Takao Hamakubo, So Iwata, Takeshi Murata
        Nature, Feb. 2012, Peer-reviewed
      • Cloning, expression and purification of the anion exchanger 1 homologue from the basidiomycete Phanerochaete chrysosporium
        Natsuko Tokuda; Kiyohiko Igarashi; Tatsuro Shimamura; Takami Yurugi-Kobayashi; Mitsunori Shiroishi; Keisuke Ito; Taishi Sugawara; Hidetsugu Asada; Takeshi Murata; Norimichi Nomura; So Iwata; Takuya Kobayashi
        PROTEIN EXPRESSION AND PURIFICATION, Sep. 2011, Peer-reviewed
      • Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis
        Hidetsugu Asada; Tomoko Uemura; Takami Yurugi-Kobayashi; Mitsunori Shiroishi; Tatsuro Shimamura; Hirokazu Tsujimoto; Keisuke Ito; Taishi Sugawara; Takanori Nakane; Norimichi Nomura; Takeshi Murata; Tatsuya Haga; So Iwata; Takuya Kobayashi
        MICROBIAL CELL FACTORIES, Apr. 2011, Peer-reviewed
      • Towards structure determination for G protein-coupled receptor
        Kobayashi Takuya; Shiroishi Mitsunori; Shimamura Tatsuro; Yurugi Takami; Asada Hidetsugu; Hino Tomoya; Arakawa Takatoshi; Murata Takeshi; Nomura Norimichi; Iwata So
        Journal of Pharmacological Sciences, 2011, Peer-reviewed
      • Gain and loss of an intron in a protein-coding gene in Archaea: the case of an archaeal RNA pseudouridine synthase gene
        Shin-ichi Yokobori; Takashi Itoh; Shigeo Yoshinari; Norimichi Nomura; Yoshihiko Sako; Akihiko Yamagishi; Tairo Oshima; Kiyoshi Kita; Yohichi Watanabe
        BMC EVOLUTIONARY BIOLOGY, Aug. 2009, Peer-reviewed
      • Fluorescence-based optimization of human bitter taste receptor expression in Saccharomyces cerevisiae
        Taishi Sugawara; Keisuke Ito; Mitsunori Shiroishi; Natsuko Tokuda; Hidetsugu Asada; Takami Yurugi-Kobayashi; Tatsuro Shimamura; Takumi Misaka; Norimichi Nomura; Takeshi Murata; Keiko Abe; So Iwata; Takuya Kobayashi
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2009, Peer-reviewed
      • Comparison of functional non-glycosylated GPCRs expression in Pichia pastoris
        Takami Yurugi-Kobayashi; Hidetsugu Asada; Mitsunori Shiroishi; Tatsuro Shimamura; Saeko Funamoto; Naoko Katsuta; Keisuke Ito; Taishi Sugawara; Natsuko Tokuda; Hirokazu Tsujimoto; Takeshi Murata; Norimichi Nomura; Kazuko Haga; Tatsuya Haga; So Iwata; Takuya Kobayashi
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2009, Peer-reviewed
      • Recognition of a common rDNA target site in archaea and eukarya by analogous LAGLIDADG and His-Cys box homing endonucleases
        Norimichi Nomura, Yayoi Nomura, Django Sussman, Daniel Klein, Barry L. Stoddard
        Nucleic Acids Research, Dec. 2008, Peer-reviewed, Lead author
      • Advanced method for high-throughput expression of mutated eukaryotic membrane proteins in Saccharomyces cerevisiae
        Keisuke Ito; Taishi Sugawara; Mitsunori Shiroishi; Natsuko Tokuda; Azusa Kurokawa; Takumi Misaka; Hisayoshi Makyio; Takami Yurugi-Kobayashi; Tatsuro Shimamura; Norimichi Nomura; Takeshi Murata; Keiko Abe; So Iwata; Takuya Kobayashi
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 2008, Peer-reviewed
      • Structure of a hyperthermophilic archaeal homing endonuclease, I-Tsp061I: Contribution of cross-domain polar networks to thermostability
        Hitoshi Nakayama; Tatsuro Shimamura; Takahito Imagawa; Nobuaki Shirai; Takashi Itoh; Yoshihiko Sako; Masashi Miyano; Haruhiko Sakuraba; Toshihisa Ohshima; Norimichi Nomura; Hideaki Tsuge
        Journal of Molecular Biology, Jan. 2007, Peer-reviewed
      • I-ApeI, a novel intron-encoded LAGLIDADG homing endonuclease from the archaeon, Aeropyrum pernix K1 (vol 33, pg e116, 2005)
        N Nomura; Y Morinaga; N Shirai; Y Sako
        NUCLEIC ACIDS RESEARCH, 2005, Peer-reviewed
      • I-Apel: a novel intron-encoded LAGLIDADG homing endonuclease from the archaeon, Aeropyrum pernix K1
        Norimichi Nomura, Yayoi Morinaga, Nobuaki Shirai, Yoshihiko Sako
        Nucleic Acids Research, 2005, Peer-reviewed, Lead author, Corresponding author
      • Crystallization and preliminary X-ray diffraction analysis of homing endonuclease I-Tsp061I
        T Imagawa; H Nakayama; N Katunuma; H Sakuraba; T Ohshima; T Itoh; Y Sako; N Nomura; H Tsuge
        ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Nov. 2004, Peer-reviewed
      • An archaeal homing endonuclease I-PogI cleaves at the insertion site of the neighboring intron, which has no nested open reading frame
        Hitoshi Nakayama, Yayoi Morinaga, Norimichi Nomura, Takuro Nunoura, Yoshihiko Sako, Aritsune Uchida
        FEBS Letters, Jun. 2003, Peer-reviewed, Corresponding author
      • Distribution of 16S rRNA introns among the family Thermoproteaceae and their evolutionary implications
        T Itoh; N Nomura; Y Sako
        EXTREMOPHILES, Jun. 2003, Peer-reviewed
      • 超好熱古細菌からの遺伝子資源の開発利用
        野村紀通; 左子芳彦
        月刊海洋号外(特集「海洋微生物II-基礎,応用研究とその利用」),No. 35, 2003
      • Homing endonuclease and mobile intron in the novel hyperthermophilic archaeon Aeropyrum pernix isolated from marine hydrothermal vent
        Yoshihiko Sako; Norimichi Nomura; Yayoi Morinaga; Aritsune Uchida
        Fisheries Science, 2002, Peer-reviewed
      • Heterogeneous yet similar introns reside in identical positions of the rRNA genes in natural isolates of the archaeon Aeropyrum pernix
        N Nomura; Y Morinaga; T Kogishi; EJ Kim; Y Sako; A Uchida
        GENE, Jul. 2002, Peer-reviewed
      • Population Dynamics of Archaeal Mobile Introns in Natural Environments: A Shrewd Invasion Strategy of the Latent Parasitic DNA
        Yayoi Morinaga; Norimichi Nomura; Yoshihiko Sako
        Microbes and Environments, 2002, Peer-reviewed
      • イントロンの進化を考える:可動遺伝因子としての古細菌rRNA遺伝子イントロン
        森永弥生; 野村紀通
        日本進化学会ニュース,Vol. 3, No. 1, p. 20-22, 2002
      • 海洋微生物 2章 海洋微生物の生理 海洋性超好熱菌 ゲノム研究からその生命像を探る
        野村紀通; 左子芳彦
        月刊海洋, 01 Nov. 2000
      • Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon, Aeropyrum pernix - Molecular evolution with alteration in product specificity
        A Tachibana; Y Yano; S Otani; N Nomura; Y Sako; M Taniguchi
        EUROPEAN JOURNAL OF BIOCHEMISTRY, Jan. 2000, Peer-reviewed
      • Two family B DNA polymerases from Aeropyrum pernix, an aerobic hyperthermophilic crenarchaeote
        IKO Cann; S Ishino; N Nomura; Y Sako; Y Ishino
        JOURNAL OF BACTERIOLOGY, Oct. 1999, Peer-reviewed
      • A cambialistic SOD in a strictly aerobic hyperthermophilic archaeon, Aeropyrum pernix
        S Yamano; Y Sako; N Nomura; T Maruyama
        JOURNAL OF BIOCHEMISTRY, Jul. 1999, Peer-reviewed
      • Isoprenoid quinones in an aerobic hyperthermophilic archaeon, Aeropyrum pernix
        F Nishida; M Nishijima; K Mochida; H Sano; N Nomura; Y Sako; T Maruyama
        FEMS MICROBIOLOGY LETTERS, May 1999, Peer-reviewed
      • Reevaluation of the phylogenetic depth of the marine aerobic hyperthermophilic archaeon Aeropyrum pernix based on comparative analysis of 23S rRNA sequences
        N Nomura; Y Sako; A Uchida
        FISHERIES SCIENCE, Apr. 1999, Peer-reviewed
      • A novel phosphoglycolipid archaetidyl(glucosyl)inositol with two sesterterpanyl chains from the aerobic hyperthermophilic archaeon Aeropyrum pernix K1
        H Morii; H Yagi; H Akutsu; N Nomura; Y Sako; Y Koga
        BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Jan. 1999, Peer-reviewed
      • Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1
        Yutaka Kawarabayasi; Yumi Hino; Hiroshi Horikawa; Syuji Yamazaki; Yuji Haikawa; Koji Jin-No; Mikio Takahashi; Mitsuo Sekine; Sin-Ichi Baba; Akiho Ankai; Hiroki Kosugi; Akira Hosoyama; Shigehiro Fukui; Yoshimi Nagai; Keiko Nishijima; Hidekazu Nakazawa; Minako Takamiya; Sayaka Masuda; Tomomichi Funahashi; Toshihiro Tanaka; Yutaka Kudoh; Jun Yamazaki; Norihiro Kushida; Akio Oguchi; Ken-Ichi Aoki; Kenji Kubota; Yoshinobu Nakamura; Norimichi Nomura; Yoshihiko Sako; Hisasi Kikuchi
        DNA Research, 1999, Peer-reviewed
      • 超好熱古細菌イントロンは転移するか? イントロンにコードされるホーミングエンドヌクレアーゼの機能
        野村紀通; 左子芳彦
        化学と生物, 25 Nov. 1998
      • Molecular characterization and postsplicing fate of three introns within the single rRNA operon of the hyperthermophilic archaeon Aeropyrum pernix K1
        Norimichi Nomura, Yoshihiko Sako, Aritsune Uchida
        Journal of Bacteriology, Jul. 1998, Peer-reviewed, Lead author, Corresponding author
      • 超好熱菌の生育特性
        野村紀通; 左子芳彦
        生物工学会誌,Vol. 76, No. 6, p. 259-263, 1998, Peer-reviewed
      • Hyperthermophilic Archaea Thriving in Marine Hydrothermal Environments
        SAKO YOSHIHIKO; NOMURA NORIMICHI
        Microbes and environments, 1998, Peer-reviewed
      • An old - fashioned newcomer : The marine hyperthermophilic archaeon Aeropyrum pernix
        NOMURA Norimichi; SAKO Yoshihiko
        バイオサイエンスとインダストリー = Bioscience & industry, 01 Sep. 1997
      • Aeropyrum pernix gen nov, sp nov, a novel aerobic hyperthermophilic archaeon growing at temperatures up to 100 degrees C
        Y Sako; N Nomura; A Uchida; Y Ishida; H Morii; Y Koga; T Hoaki; T Maruyama
        INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, Oct. 1996, Peer-reviewed

      Misc.

      • B型肝炎ウイルス感染受容体NTCPの構造
        野村紀通
        医学のあゆみ, Jun. 2023, Invited
      • スペルミジンはT細胞の脂肪酸酸化を直接活性化し老化による抗腫瘍免疫の低下を回復させる
        茶本健司,Muna Al-Habsi,松本健,野村紀通
        Japanense Scientists in Science 2022―サイエンス誌に載った日本人研究者 (2023年版), Mar. 2023, Invited
      • フェルスター共鳴エネルギー移動の原理に基づく二光子励起用光遺伝学ツールの開発
        金城智章; 寺井健太; 堀田彰一朗; 野村紀通; 隅山健太; 岩田想; 松田道行; 松田道行
        日本細胞生物学会大会(Web), 2019
      • ヒトプロスタグランジンE2受容体EP3-Gタンパク質複合体のクライオ電子顕微鏡単粒子解析
        寿野良二; 杉田征彦; 森本和志; 辻本浩一; 廣瀬未果; 寿野千代; 野村紀通; 岩崎憲二; 加藤貴之; 岩田想; 小林拓也
        日本蛋白質科学会年会プログラム・要旨集, 2021
      • Structure and Biochemical Characterization of the Mammalian Fructose Transporter GLUT5
        Gregory Verdon; Hae Joo Kang; Saba Abdul-Hussein; Abdul Aziz Qureshi; Michihiro Kasahara; So Iwata; Norimichi Nomura; David Drew
        BIOPHYSICAL JOURNAL, Jan. 2015
      • 古細菌タンパク質遺伝子のイントロンの解析
        渡辺洋一; 吉成茂夫; 野村紀通; 伊藤隆; 横堀伸一; 左子芳彦; 山岸明彦; 大島泰郎; 北潔
        日本Archaea研究会講演会要旨集, 2005
      • 古細菌タンパク質遺伝子に存在するイントロンの解析
        渡辺洋一; 吉成茂夫; 野村紀通; 伊藤隆; 横堀伸一; HALLAM Steven; 左子芳彦; 山岸明彦; 大島泰郎; 北潔
        日本分子生物学会年会講演要旨集, 2005
      • A-06 超好熱古細菌イントロンの水平伝播を司る鍵酵素I-ApeIIの機能と構造(極限環境,口頭発表)
        左子 芳彦; 森永 弥生; 野村 紀通
        日本微生物生態学会講演要旨集, 21 Nov. 2004
      • 超好熱古細菌からの遺伝子資源の開発利用 (総特集 海洋微生物(2)基礎,応用研究とその利用) -- (3章 遺伝子解析,抗原とその応用研究)
        野村 紀通; 左子 芳彦
        海洋 号外, 2003
      • A-18 熱水環境における超好熱性古細菌の可動性イントロンの伝播と進化(極限環境2,口頭発表)
        左子 芳彦; 野村 紀通; 森永 弥生; 中山 仁志; 伊藤 隆; 内田 有恆
        日本微生物生態学会講演要旨集, 15 Nov. 2002
      • A-22 超好熱古細菌Aeropyrumのモデル生物としての基盤整備(極限環境,A会場,口頭発表)
        左子 芳彦; 野村 紀通; 内田 有恆
        日本微生物生態学会講演要旨集, 09 Nov. 2001
      • Functional genomics of hyperthermophiles and its application to discovery of useful genetic resources.
        Nomura Norimichi; Morinaga Yayoi; Kim Eunji; Sako Yoshihiko
        日本生物工学会大会講演要旨集, 24 Aug. 2001
      • 海洋熱水環境に生息する未知なる超好熱菌の探索
        左子 芳彦; 野村 紀通; 高井 研
        日本農芸化学会誌, 05 Mar. 1999
      • 好気性超好熱古細菌"Aeropyrus pernix"K1の脂質 : 微生物
        森井 宏幸; 左子 芳彦; 野村 紀通; 古賀 洋介
        日本農藝化學會誌, 05 Jul. 1995

      Presentations

      • 抗体を用いた膜タンパク質構造研究
        野村紀通
        京都大学BINDS共同シンポジウム「オープンイノベーションから創薬へ 2023」, 25 Oct. 2023, Invited
      • X線結晶構造解析で見るTNF阻害剤の分子機構
        野村紀通
        Ulcerative Colitis Web Seminar ーTNFα阻害薬をMOAから再考するー (主催:田辺三菱製薬株式会社), 28 Sep. 2023, Invited
      • X線結晶構造解析で見るTNF阻害剤の分子機構
        野村紀通
        リウマチWebセミナー:TNFαを再考する(主催:田辺三菱製薬株式会社), 03 Mar. 2023, Invited
      • Unveiling membrane protein structures with the aid of antibody toolkits
        Norimichi Nomura
        OIST-Kyoto University Joint Workshop -Challenges in Biomedical Complexity-, 04 Nov. 2022, OIST, Kyoto University, Invited
      • X線結晶構造解析で見るTNF阻害剤の分子機構
        野村紀通
        TNF Value Creation Seminar(主催:ヤンセンファーマ株式会社), 26 Oct. 2022, Invited
      • X線結晶構造解析で見るTNF阻害剤の分子機構
        野村紀通
        Golimumab Value Creation Seminar(主催:田辺三菱製薬株式会社), 22 Sep. 2022, Invited
      • 膜タンパク質構造研究 この10年
        野村紀通
        京都大学大学院医学研究科 医学研究支援センター開設10周年記念セミナー(第8回), 01 Aug. 2022, Invited
      • 次世代構造創薬研究を先導するヒト膜タンパク質・抗体の生産技術
        野村紀通
        創薬産業構造解析コンソーシアム 分野別研究会, 14 Mar. 2017, Invited
      • 抗体フラグメントを用いたヒト膜タンパク質の結晶構造解析
        野村紀通
        BioJapan2010 アカデミックシーズ発表会, 29 Sep. 2010, Invited
      • Chapter 5 - The Intervening Removable Affinity Tag (iRAT) System for the Production of Recombinant Antibody Fragments (pp. 77-103)
        Norimichi Nomura, Yayoi Nomura, Yumi Sato, So Iwata, Contributor
        Methods in Molecular Biology, Vol. 2247, Porterszman, A. (Eds.) “Multiprotein Complexes”, Springer, Jan. 2021, Refereed
      • Chapter 19 - Crystallographic approaches to study the interaction modes of PD-1- and CTLA-4-blocking antibodies (pp. 383-399)
        Norimichi Nomura; Yayoi Nomura; Yumi Sato; So Iwata, Contributor, Chapter 19 - Crystallographic approaches to study the interaction modes of PD-1- and CTLA-4-blocking antibodies
        Methods in Enzymology, Vol. 629, "Tumor Immunology and Immunotherapy – Molecular Methods" (Edited by Lorenzo Galluzzi, Nils-Petter Rudqvist), Academic Press, Inc., Dec. 2019, Refereed
      • Chapter 7: Generation of conformation-specific antibody fragments for crystallization of the multidrug resistance transporter MdfA (pp. 97-109)
        Jaenecke F; Nakada-Nakura, Y; Nagarathinam, K; Ogasawara, S; Liu, K; Hotta, Y; Iwata, S; Nomura, N; Tanabe, M, Contributor, Chapter 7: Generation of conformation-specific antibody fragments for crystallization of the multidrug resistance transporter MdfA (pp. 97-109)
        Methods in Molecular Biology, Vol. 1700, Yamaguchi, A. and Nishino, K. (Eds.) “Bacterial Multidrug Exporters”, Springer, 2018, Refereed
      • 基礎研究 第4章 GLUT5の立体構造とフルクトース輸送機構」(pp.28-34)
        野村紀通; 岩田想, Contributor, 4章「GLUT5の立体構造とフルクトース輸送機構」(pp.28-34)
        『糖尿病学2016』(門脇孝 編)診断と治療社, May 2016, Not refereed
      • 序章 膜タンパク質の重要性とその構造が拓く未来 (pp. 1-10)
        村田武士; 野村紀通; 小林拓也; 岩田想, Contributor, 序章 膜タンパク質の重要性とその構造が拓く未来
        『膜タンパク質構造研究』(岩田 想 編)化学同人, Oct. 2013, Not refereed
      • 14章 抗体を用いた膜タンパク質の結晶化 (pp.120-128)
        野村紀通, Contributor, 14章「抗体を用いた膜タンパク質の結晶化」
        『膜タンパク質構造研究』(岩田 想 編)化学同人, Oct. 2013, Not refereed
      • Genus II. Aeropyrum Sako, Nomura,Uchida, Ishida, Morii, Koga, Hoaki and Maruyama 1996, 1075VP
        Sako Y; N.Nomura
        “Bergey’s Manual of Systematic Bacteriology (Second Edition) Volume One, The Archaea and Deeply Branching and Phototrpohic Bacteria” (D.R. Boone, R.W. Castenholz and G.M. Garrity, eds.) , Springer-Verlag,pp.183-184, 2001, Not refereed

      Industrial Property Rights

      • 特願2024-015255, 皮膚筋炎又は間質性肺炎の患者の治療抵抗性の予測方法、及び当該方法に使用されるキット
        笹井蘭、笹井恒雄、野中元裕、野村紀通
      • 特願2021-088794, 非変性チャネルロドプシン検出キット
        加藤英明、福田昌弘、濡木理、草木迫司、岩田想、野村紀通、劉紅、植村智子、 井上謙一
      • 特願2011-246364, 抗ヒトバンド3モノクローナル抗体
        荒川孝俊; 小林拓也; 万木貴美; 日野智也; 村田武士; 野村紀通; 岩田想; 浜窪隆雄; 岩成宏子; 望月康弘; 濱崎直孝
      • PCT/JP2010/057631, 膜蛋白質の立体構造を認識するモノクローナル抗体のスクリーニング方法
        日野智也; 村田武士; 荒川孝俊; 野村紀通; 岩田想
      • 特願2009-254463, 抗ヒトアデノシンA2a受容体モノクローナル抗体
        荒川孝俊; 日野智也; 寿野千代; 野村紀通; 村田武士; 岩田想; 浜窪隆雄; 岩成宏子; 中田淑子; 新井修
      • 特願2009-110994, 膜蛋白質の立体構造を認識するモノクローナル抗体のスクリーニング方法
        日野智也; 村田武士; 荒川孝俊; 野村紀通; 岩田想

      Awards

      • 1999
        Inoue Foundation for Science, Inoue Research Award for Young Scientists (Inoue Foundation of Science)

      External funds: Kakenhi

      • Structural biology of the hepatitis B virus entry and its inhibition
        Grant-in-Aid for Scientific Research (B)
        Basic Section 49060:Virology-related
        Kyoto University
        野村 紀通
        From 01 Apr. 2023, To 31 Mar. 2026, Granted
        ウイルス受容体;エンベロープタンパク質;クライオ電子顕微鏡;宿主因子;B型肝炎ウイルス
      • Time-resolved XFEL crystallography and rational engineering of light-driven proteins
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        Kyoto University
        岩田 想
        From 28 Jun. 2019, To 31 Mar. 2024, Granted
        X線自由電子レーザー;構造ダイナミクス;光遺伝学;フォトクロミックタンパク質;X線結晶構造解析;膜タンパク質;時分割X線結晶構造解析;チャネルロドプシン
      • Elucidation of multidrug recognition and transport mechanisms of MFS-type multidrug efflux transporters
        Grant-in-Aid for Scientific Research (B)
        Basic Section 43030:Functional biochemistry-related
        High Energy Accelerator Research Organization
        Tanabe Mikio
        From 01 Apr. 2019, To 31 Mar. 2023, Project Closed
        薬剤排出;構造解析;MFS輸送体;膜輸送;トランスポーター;細菌感染症;薬剤耐性;物質輸送;多剤排出トランスポーター;病原性細菌;薬剤排出トランスポーター;抗体;再構成;病原菌
      • ヒト膜タンパク質を標的とした中分子構造創薬研究の基盤構築
        Grant-in-Aid for Scientific Research (A)
        Medium-sized Section 37:Biomolecular chemistry and related fields
        Kyoto University
        岩田 想
        From 01 Apr. 2019, To 31 Mar. 2024, Granted
        膜タンパク質;中分子;クライオ電子顕微鏡;創薬;B型肝炎ウイルス;創薬ターゲット;中分子ペプチド;クライオ電子顕微鏡単粒子解析;ウイルス感染受容体;抗ウイルス薬;抗体;ファージディスプレイ;X線結晶構造解析;構造生物学
      • Creation and crystallographic studies of artificial medium-sized aptamers that modulate membrane protein functions
        Grant-in-Aid for Scientific Research (C)
        Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
        Kyoto University
        Norimichi Nomura
        From 01 Apr. 2018, To 31 Mar. 2021, Project Closed
        膜タンパク質;中分子創薬;X線結晶構造解析;クライオ電子顕微鏡単粒子解析;ファージディスプレイ;中分子;抗体;創薬;創薬ターゲット;中分子ペプチド;アロステリックモジュレーター;阻害剤
      • Differential analysis of the crystal structures of active / inactive orexin receptor contributing to rational development of sleep control drug
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Ryoji Suno
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        ヒト膜受容体;GPCR;シグナル伝達;X線結晶構造解析;抗体;薬剤開発;ナルコレプシー;睡眠;機能性抗体;膜タンパク質;創薬
      • Crystallographic study of the mammalian bile acid transporter NTCP in complex with its conformation-specific antibodies
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Norimichi Nomura
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        膜タンパク質;抗体;X線結晶構造解析;創薬ターゲット;高脂血症;胆汁酸;トランスポーター;コレステロール;膜蛋白質
      • Trial for determining the structure of CXCR7
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Tatsuro Shimamura
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        結晶構造解析;Gタンパク質共役型受容体;シグナル伝達;タンパク質;G蛋白質共役型受容体;蛋白質;癌
      • Structure determination of human membrane transporters
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Tatsuro SHIMAMURA
        From 01 Apr. 2013, To 31 Mar. 2015, Project Closed
        膜輸送体;結晶構造解析;創薬;輸送体;トランスポーター;X線結晶構造解析
      • Development of antibody stabilizing active or inactive state of GPCRs.
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Takuya KOBAYASHI
        From 01 Apr. 2010, To 31 Mar. 2012, Project Closed
        モノクローナル抗体;GPCR;X線結晶構造解析;立体構造認識抗体;アデノシンA2a受容体;結晶構造解析
      • Technologicaldevelopment for construction of synthetic proteins that facilitate membrane protein crystallization
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Norimichi NOMURA
        From 01 Apr. 2010, To 31 Mar. 2013, Project Closed
        膜蛋白質;X線結晶構造解析;結晶化リガンド;抗体フラグメント;ファージディスプレイ;膜輸送体;プァージディスプレイ
      • ゲノム工学技術への応用をめざした人工レアカッター酵素の開発と分子設計原理の解明
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        野村 紀通
        From 01 Apr. 2004, To 31 Mar. 2006, Project Closed
        古細菌;ゲノム多型;イントロンホーミング;遺伝子水平伝播;ホーミングエンドヌクレアーゼ;利己的遺伝子;可動性イントロン;超好熱菌
      • Structural analysis of endonuclease-DNA interaction and alteration of substrate specificity
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Keiko KITA
        From 01 Apr. 2004, To 31 Mar. 2007, Project Closed
        制限酵素;タンパク質工学;特異性改変;DNA結合タンパク質;結晶構造解析;制限修飾系;エンドヌクレアーゼ;結晶化;部位特異的変異;金属イオン;界面活性剤;転写制御因子;DNA認識機構;構造生物学, Restriction endonuclease;Protein engineering;Alteration of substrate specificity;DNA-binding protein;Crystal structure analysis
      • Large scale collection and their industrial application of hyperthemophilic archaeal genome from deep sea hydrothermal envirenments
        Grant-in-Aid for Scientific Research (A)
        Kyoto University
        Yoshihiko SAKO
        From 01 Apr. 2004, To 31 Mar. 2008, Project Closed
        深海熱水環境;超好熱菌;古細菌;ゲノム;遺伝子資源;耐熱性酵素;ヒドロゲナーゼ;エンドヌクレアーゼ;など;ヌクレアーゼ;深海熱水孔;ホーミングエンドヌクレアーゼ;ホーミングエンドヌクレアー;海底熱水口;有用ゲノム資源;メタゲノム解析;環境バイオテクノロジー;知的財産権, deep sea hydrothermal environment;hyperthermophilles;Archaea;genome;genetic resources;thermostable enzyme;hydrogenase;endonuclease
      • 古細菌ゲノムに散在する可動性イントロンの集団内伝播と進化のダイナミクス
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        野村 紀通
        From 01 Apr. 2004, To 31 Mar. 2005, Project Closed
        古細菌;ゲノム多型;イントロンホーミング;遺伝子水平伝播;ホーミングエンドヌクレアーゼ;利己的遺伝子;可動性イントロン;超好熱菌
      • 古細菌ゲノムに散在する可動性イントロンの集団内伝播と進化のダイナミクス
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        野村 紀通
        From 01 Apr. 2003, To 31 Mar. 2004, Project Closed
        古細菌;ゲノム多型;イントロンホーミング;遺伝子水平伝播;ホーミングエンドヌクレアーゼ;利己的遺伝子;可動性イントロン;超好熱菌
      • 古細菌における制限酵素遺伝子群のゲノム規模での網羅的単離・同定
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        野村 紀通
        From 01 Apr. 2002, To 31 Mar. 2004, Project Closed
        古細菌;ゲノム;有用遺伝子資源;II型制限酵素;ホーミングエンドヌクレアーゼ;蛋白質-DNA分子間相互作用;可動性イントロン;超好熱菌;制限修飾系;バイオインフォマティックス;無細胞蛋白質合成系;耐熱性酵素
      • 海洋性好熱古細菌における新規制限酵素遺伝子群の網羅的開発に関する研究
        Grant-in-Aid for Exploratory Research
        Kyoto University
        左子 芳彦
        From 01 Apr. 2002, To 31 Mar. 2005, Project Closed
        古細菌;ゲノム多型;イントロンホーミング;遺伝子水平伝播;ホーミングエンドヌクレアーゼ;利己的遺伝子;可動性イントロン;超好熱菌;ゲノム;有用遺伝子資源;II型制限酵素;タンパク質-DNA相互作用;制限修飾系;バイオインフォマテイックス;無細胞蛋白質合成系;耐熱性酵素
      • 古細菌ゲノムの体系的・網羅的機能解析を支援する逆遺伝学的方法論の開発
        Grant-in-Aid for Scientific Research on Priority Areas (C)
        Biological Sciences
        Kyoto University
        野村 紀通
        From 01 Apr. 2001, To 31 Mar. 2002, Project Closed
        古細菌;逆遺伝学;遺伝子破壊;超好熱菌;イントロン;ホーミング;ゲノム;進化
      • 超好熱古細菌ゲノムの体系的機能解析のための分子遺伝学的基盤の構築
        Grant-in-Aid for Encouragement of Young Scientists (A)
        Kyoto University
        野村 紀通
        From 01 Apr. 2000, To 31 Mar. 2002, Project Closed
        古細菌;逆遺伝学;遺伝子破壊;超好熱菌;イントロン;ホーミング;ゲノム;進化
      • Isolation of novel thermophilic organisms from marine hydrothermal environments and the development of new catalytic functions
        Grant-in-Aid for Scientific Research (B)
        KYOTO UNIVERSITY
        Yoshihiko SAKO
        From 01 Apr. 2000, To 31 Mar. 2003, Project Closed
        超好熱菌;海底熱水孔;古細菌;耐熱酵素;ホーミングエンドヌクレアーゼ;水素細菌;イントロン;プロテアーゼ;好熱遺伝子群;好気性超好熱菌;分子系統解析, hyperthermophilic microorganism;marine hydrothermal vent;Archaea;heat stable enzymes;homing endonuclease;hydrogen bacteria;Intron;restriction enzyme
      • 古細菌ゲノムの体系的・網羅的機能解析を支援する逆遺伝学的方法論の開発
        Grant-in-Aid for Scientific Research on Priority Areas (C)
        Biological Sciences
        Kyoto University
        野村 紀通
        From 01 Apr. 2000, To 31 Mar. 2001, Project Closed
        古細菌;逆遺伝学;遺伝子破壊;超好熱菌;イントロン;ホーミング
      • テトラスパニンを介した新たながん転移促進機構の解明
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 50:Oncology and related fields
        Kyoto University
        野村 紀通
        From 30 Jun. 2023, To 31 Mar. 2025, Granted
        テトラスパニン;がん転移・悪性化進展;仮足形成;クライオ電子顕微鏡単粒子解析;クライオ電子線トモグラフィー解析

      External funds: others

      • がん細胞メチオニン輸送体を標的とした構造創薬研究
        公益財団法人 アステラス病態代謝研究会, 2023年度研究助成
        From 01 Jan. 2024, To 31 Dec. 2025
        野村紀通
        研究代表者
      • B 型肝炎ウイルス細胞侵入複合体の形成機序と分子構造の解明
        公益財団法人 武田科学振興財団, 2023年度 生命科学研究助成
        From 01 Oct. 2023, To 31 Mar. 2028
        野村紀通
        研究代表者
      • B 型肝炎ウイルス細胞侵入複合体の形成機序と分子構造に関する研究
        三菱財団, 第54回 (2023年度) 自然科学研究助成
        From 01 Oct. 2023, To 30 Sep. 2024
        野村紀通
        研究代表者
      • B型肝炎ウイルス-宿主相互作用とその制御に関するクライオ電子顕微鏡構造研究
        京都大学医生物学研究所, ウイルス・幹細胞システム医生物学共同研究拠点 2023年度共同研究
        From 01 Apr. 2023, To 31 Mar. 2024
        野村紀通
        野田岳志
        研究代表者
      • 抗体を用いた膜タンパク質構造研究支援
        日本医療研究開発機構 (AMED), 生命科学・創薬研究支援基盤事業 (BINDS)
        From 01 Apr. 2022, To 31 Mar. 2027
        岩田 想
        野村紀通
        分担
      • ウイルス侵入受容体膜タンパク質および関連複合体のクライオ電子顕微鏡構造研究
        京都大学医生物学研究所, ウイルス・幹細胞システム医生物学共同研究拠点 2022年度共同研究課題
        From 01 Apr. 2022, To 31 Mar. 2023
        野村紀通
        代表
      • クライオ電子顕微鏡を用いたB型肝炎ウイルス侵入受容体の精密立体構造解析
        京都大学ウイルス・再生医科学研究所, ウイルス感染症・生命科学先端融合的共同研究拠点 2021年度共同研究課題
        From 01 Apr. 2021, To 31 Mar. 2022
        野村紀通
        代表
      • 次世代構造創薬研究を先導するヒト膜タンパク質・抗体の生産技術支援
        日本医療研究開発機構 (AMED)  創薬等ライフサイエンス研究支援基盤事業 (BINDS)
        From 01 Apr. 2017, To 31 Mar. 2022
        分担
      • 膜タンパク質の細胞外ドメインを結合標的とする機能性ヒト抗体の高効率作製と構造デザイン
        日本医療研究開発機構 (AMED)  創薬基盤推進研究事業
        From 01 Apr. 2018, To 31 Mar. 2023
        分担
      • 任意のDNA配列を特異的に切断する人工制限酵素の分子設計と結晶構造解析
        京都大学教育研究振興財団 海外派遣助成(長期)
        From 01 Sep. 2005, To 31 Aug. 2006
        野村紀通
      list
        Last Updated :2024/03/21

        Education

        Teaching subject(s)

        • From Apr. 2016, To Mar. 2017
          Fundamental Chemical Experiments
          Fall, 全学共通科目

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