| Kazuma Murakami, Tomomi Yamaguchi, Naotaka Izuo, Toshiaki Kume, Hideyuki Hara, Kazuhiro Irie |
Kazuma Murakami, Tomomi Yamaguchi, Naotaka Izuo, Toshiaki Kume, Hideyuki Hara, Kazuhiro Irie |
Kazuma Murakami, Tomomi Yamaguchi, Naotaka Izuo, Toshiaki Kume, Hideyuki Hara, Kazuhiro Irie |
Synthetic and Biophysical Studies on the Toxic Conformer in Amyloid β with the E22Δ Mutation in Alzheimer Pathology. |
Synthetic and Biophysical Studies on the Toxic Conformer in Amyloid β with the E22Δ Mutation in Alzheimer Pathology. |
Synthetic and Biophysical Studies on the Toxic Conformer in Amyloid β with the E22Δ Mutation in Alzheimer Pathology. |
ACS chemical neuroscience, 11, 19, 3017-3024 |
ACS chemical neuroscience, 11, 19, 3017-3024 |
ACS chemical neuroscience, 11, 19, 3017-3024 |
2020/10/07 |
|
英語 |
研究論文(学術雑誌) |
公開 |
| Yayoi Obata, Kazuma Murakami, Taiji Kawase, Kenji Hirose, Naotaka Izuo, Takahiko Shimizu, Kazuhiro Irie |
Yayoi Obata, Kazuma Murakami, Taiji Kawase, Kenji Hirose, Naotaka Izuo, Takahiko Shimizu, Kazuhiro Irie |
Yayoi Obata, Kazuma Murakami, Taiji Kawase, Kenji Hirose, Naotaka Izuo, Takahiko Shimizu, Kazuhiro Irie |
Detection of Amyloid β Oligomers with RNA Aptamers in AppNL-G-F/NL-G-F Mice: A Model of Arctic Alzheimer's Disease. |
Detection of Amyloid β Oligomers with RNA Aptamers in AppNL-G-F/NL-G-F Mice: A Model of Arctic Alzheimer's Disease. |
Detection of Amyloid β Oligomers with RNA Aptamers in AppNL-G-F/NL-G-F Mice: A Model of Arctic Alzheimer's Disease. |
ACS omega, 5, 34, 21531-21537 |
ACS omega, 5, 34, 21531-21537 |
ACS omega, 5, 34, 21531-21537 |
2020/09/01 |
|
英語 |
研究論文(学術雑誌) |
公開 |
| Kazuma Murakami, a, Haruka Kato, Mizuho Hanaki, a, Yoko Monobe, Ken-ichi Akagi, Taiji Kawase, c, Kenji Hirosec, Kazuhiro Irie |
Kazuma Murakami, a, Haruka Kato, Mizuho Hanaki, a, Yoko Monobe, Ken-ichi Akagi, Taiji Kawase, c, Kenji Hirosec, Kazuhiro Irie |
Kazuma Murakami, a, Haruka Kato, Mizuho Hanaki, a, Yoko Monobe, Ken-ichi Akagi, Taiji Kawase, c, Kenji Hirosec, Kazuhiro Irie |
Synthetic and biochemical studies on the effect of persulfidation on disulfide dimer models of amyloid b42 at position 35 in Alzheimer's etiology |
Synthetic and biochemical studies on the effect of persulfidation on disulfide dimer models of amyloid b42 at position 35 in Alzheimer's etiology |
Synthetic and biochemical studies on the effect of persulfidation on disulfide dimer models of amyloid b42 at position 35 in Alzheimer's etiology |
RSC Adv., 10, 19506 |
RSC Adv., 10, 19506 |
RSC Adv., 10, 19506 |
2020/05 |
有 |
|
|
公開 |
| Kento Tsukada, Shono Shinki, Akiho Kaneko, Kazuma Murakami, Kazuhiro Irie, Masatoshi Murai, Hideto Miyoshi, Shingo Dan, Kumi Kawaji, Hironori Hayashi, Eiichi N Kodama, Aki Hori, Emil Salim, Takayuki Kuraishi, Naoya Hirata, Yasunari Kanda, Teigo Asai |
Kento Tsukada, Shono Shinki, Akiho Kaneko, Kazuma Murakami, Kazuhiro Irie, Masatoshi Murai, Hideto Miyoshi, Shingo Dan, Kumi Kawaji, Hironori Hayashi, Eiichi N Kodama, Aki Hori, Emil Salim, Takayuki Kuraishi, Naoya Hirata, Yasunari Kanda, Teigo Asai |
Kento Tsukada, Shono Shinki, Akiho Kaneko, Kazuma Murakami, Kazuhiro Irie, Masatoshi Murai, Hideto Miyoshi, Shingo Dan, Kumi Kawaji, Hironori Hayashi, Eiichi N Kodama, Aki Hori, Emil Salim, Takayuki Kuraishi, Naoya Hirata, Yasunari Kanda, Teigo Asai |
Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones.  |
Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones. |
Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones. |
Nature communications, 11, 1, 1830-1830 |
Nature communications, 11, 1, 1830-1830 |
Nature communications, 11, 1, 1830-1830 |
2020/04/14 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Kazuma Murakami, Yayoi Obata, Asa Sekikawa, Haruka Ueda, Naotaka Izuo, Tatsuya Awano, Keiji Takabe, Takahiko Shimizu, Kazuhiro Irie |
Kazuma Murakami, Yayoi Obata, Asa Sekikawa, Haruka Ueda, Naotaka Izuo, Tatsuya Awano, Keiji Takabe, Takahiko Shimizu, Kazuhiro Irie |
Kazuma Murakami, Yayoi Obata, Asa Sekikawa, Haruka Ueda, Naotaka Izuo, Tatsuya Awano, Keiji Takabe, Takahiko Shimizu, Kazuhiro Irie |
An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease. |
An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease. |
An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease. |
The Journal of biological chemistry, 295, 15, 4870-4880 |
The Journal of biological chemistry, 295, 15, 4870-4880 |
The Journal of biological chemistry, 295, 15, 4870-4880 |
2020/04/10 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Ryotaro Yagita a, Kazuma Murakami a, Hisafumi Ikeda b, Kazuhiro Irie a |
Ryotaro Yagita a, Kazuma Murakami a, Hisafumi Ikeda b, Kazuhiro Irie a |
Ryotaro Yagita a, Kazuma Murakami a, Hisafumi Ikeda b, Kazuhiro Irie a |
Synthesis and physicochemical properties of 20-mer peptide nucleic acid conjugates with testosterone 17β-carboxylic acid |
Synthesis and physicochemical properties of 20-mer peptide nucleic acid conjugates with testosterone 17β-carboxylic acid |
Synthesis and physicochemical properties of 20-mer peptide nucleic acid conjugates with testosterone 17β-carboxylic acid |
Tetrahedron Letters, 61, 151781 |
Tetrahedron Letters, 61, 151781 |
Tetrahedron Letters, 61, 151781 |
2020/04 |
有 |
|
|
公開 |
| T. Imamura, Y. T. Yanagihara, Y. Ohyagi, N. Nakamura, K. M. Iinuma, R. Yamasaki, H. Asai, M. Maeda, K. Murakami, K. Irie, J.-i. Kira |
T. Imamura, Y. T. Yanagihara, Y. Ohyagi, N. Nakamura, K. M. Iinuma, R. Yamasaki, H. Asai, M. Maeda, K. Murakami, K. Irie, J.-i. Kira |
Tomohiro Imamura, Yuki T Yanagihara, Yasumasa Ohyagi, Norimichi Nakamura, Kyoko M Iinuma, Ryo Yamasaki, Hirohide Asai, Masahiro Maeda, Kazuma Murakami, Kazuhiro Irie, Jun-Ichi Kira |
Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer’s disease model |
Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer’s disease model |
Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model. |
Neurobiol. Dis., 137, 104739-104739 |
Neurobiol. Dis., 137, 104739-104739 |
Neurobiology of disease, 137, 104739-104739 |
2020/04 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| K. Murakami, M. Yoshimura, S. Nakagawa, T. Kume, T. Kondo, H. Inoue, K. Irie |
K. Murakami, M. Yoshimura, S. Nakagawa, T. Kume, T. Kondo, H. Inoue, K. Irie |
Kazuma Murakami, Mayuko Yoshimura, Shota Nakagawa, Toshiaki Kume, Takayuki Kondo, Haruhisa Inoue, Kazuhiro Irie |
Evaluation of toxic amyloid β42 oligomers in rat primary cerebral cortex cells and human iPS-derived neurons treated with 10-Me-Aplog-1, a new PKC activator |
Evaluation of toxic amyloid β42 oligomers in rat primary cerebral cortex cells and human iPS-derived neurons treated with 10-Me-Aplog-1, a new PKC activator |
Evaluation of Toxic Amyloid 42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator. |
Int. J. Mol. Sci., 21, 4, 1179 |
Int. J. Mol. Sci., 21, 4, 1179 |
International journal of molecular sciences, 21, 4, 1179 |
2020/02/11 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| N. Izuo, K. Murakami, Y. Fujihara, M. Maeda, T. Saito, T. C. Saido, K. Irie, T. Shimizu |
N. Izuo, K. Murakami, Y. Fujihara, M. Maeda, T. Saito, T. C. Saido, K. Irie, T. Shimizu |
Naotaka Izuo, Kazuma Murakami, Yoshitaka Fujihara, Masahiro Maeda, Takashi Saito, Takaomi C Saido, Kazuhiro Irie, Takahiko Shimizu |
An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease |
An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease |
An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease. |
Biochem. Biophys. Res. Commun., 515, 3, 462-467 |
Biochem. Biophys. Res. Commun., 515, 3, 462-467 |
Biochemical and biophysical research communications, 515, 3, 462-467 |
2019/07/30 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Kazuma Murakami, Kazuhiro Irie |
Kazuma Murakami, Kazuhiro Irie |
Kazuma Murakami, Kazuhiro Irie |
Three Structural Features of Functional Food Components and Herbal Medicine with Amyloid β42 Anti-Aggregation Properties. |
Three Structural Features of Functional Food Components and Herbal Medicine with Amyloid β42 Anti-Aggregation Properties. |
Three Structural Features of Functional Food Components and Herbal Medicine with Amyloid β42 Anti-Aggregation Properties. |
Molecules (Basel, Switzerland), 24, 11, 2125 |
Molecules (Basel, Switzerland), 24, 11, 2125 |
Molecules (Basel, Switzerland), 24, 11, 2125 |
2019/06/05 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Yumi Irie, Mizuho Hanaki, Kazuma Murakami, Tsuneo Imamoto, Takumi Furuta, Takeo Kawabata, Taiji Kawase, Kenji Hirose, Yoko Monobe, Ken-Ichi Akagi, Ryo C Yanagita, Kazuhiro Irie |
Yumi Irie, Mizuho Hanaki, Kazuma Murakami, Tsuneo Imamoto, Takumi Furuta, Takeo Kawabata, Taiji Kawase, Kenji Hirose, Yoko Monobe, Ken-Ichi Akagi, Ryo C Yanagita, Kazuhiro Irie |
Yumi Irie, Mizuho Hanaki, Kazuma Murakami, Tsuneo Imamoto, Takumi Furuta, Takeo Kawabata, Taiji Kawase, Kenji Hirose, Yoko Monobe, Ken-Ichi Akagi, Ryo C Yanagita, Kazuhiro Irie |
Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation. |
Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation. |
Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation. |
Chemical communications (Cambridge, England), 55, 2, 182-185 |
Chemical communications (Cambridge, England), 55, 2, 182-185 |
Chemical communications (Cambridge, England), 55, 2, 182-185 |
2018/12/20 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Yusuke Kageyama, Atsushi Saito, Olga Pletnikova, Gay L Rudow, Yumi Irie, Yang An, Kazuma Murakami, Kazuhiro Irie, Susan M Resnick, David R Fowler, Lee J Martin, Juan C Troncoso |
Yusuke Kageyama, Atsushi Saito, Olga Pletnikova, Gay L Rudow, Yumi Irie, Yang An, Kazuma Murakami, Kazuhiro Irie, Susan M Resnick, David R Fowler, Lee J Martin, Juan C Troncoso |
Yusuke Kageyama, Atsushi Saito, Olga Pletnikova, Gay L Rudow, Yumi Irie, Yang An, Kazuma Murakami, Kazuhiro Irie, Susan M Resnick, David R Fowler, Lee J Martin, Juan C Troncoso |
Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques. |
Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques. |
Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques. |
Scientific reports, 8, 1, 16895-16895 |
Scientific reports, 8, 1, 16895-16895 |
Scientific reports, 8, 1, 16895-16895 |
2018/11/15 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Murakami, K, Yoshioka, T, Horii, S, Hanaki, M, Midorikawa, S, Taniwaki, S, Gunji, H, Akagi, K, Kawase, T, Hirose, K, Irie, K |
Murakami, K, Yoshioka, T, Horii, S, Hanaki, M, Midorikawa, S, Taniwaki, S, Gunji, H, Akagi, K, Kawase, T, Hirose, K, Irie, K |
Kazuma Murakami, Takuya Yoshioka, Shiori Horii, Mizuho Hanaki, Satohiro Midorikawa, Shinji Taniwaki, Hiroki Gunji, Ken-Ichi Akagi, Taiji Kawase, Kenji Hirose, Kazuhiro Irie |
Role of carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers |
Role of carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers |
Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers. |
Chem. Commun., 54, 49, 6272-6275 |
Chem. Commun., 54, 49, 6272-6275 |
Chemical communications (Cambridge, England), 54, 49, 6272-6275 |
2018/06/14 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Hanaki, M, Murakami, K, Katayama, S, Akagi, K, Irie, K |
Hanaki, M, Murakami, K, Katayama, S, Akagi, K, Irie, K |
Mizuho Hanaki, Kazuma Murakami, Sumie Katayama, Ken-Ichi Akagi, Kazuhiro Irie |
Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine |
Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine |
Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine. |
Bioorg. Med. Chem., 26, 8, 1538-1546 |
Bioorg. Med. Chem., 26, 8, 1538-1546 |
Bioorganic & medicinal chemistry, 26, 8, 1538-1546 |
2018/05/01 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| 泉尾直孝, 清水孝彦, 村上一馬, 入江一浩 |
泉尾直孝, 清水孝彦, 村上一馬, 入江一浩 |
泉尾直孝, 清水孝彦, 村上一馬, 入江一浩 |
アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発 |
アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発 |
アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発 |
医薬品医療機器レギュラトリーサイエンス, 49, 5, 312-318 |
医薬品医療機器レギュラトリーサイエンス, 49, 5, 312-318 |
医薬品医療機器レギュラトリーサイエンス, 49, 5, 312-318 |
2018 |
|
日本語 |
研究論文(学術雑誌) |
公開 |
| Izuo, N, Kasahara, C, Murakami, K, Kume, T, Maeda, M, Irie, K, Yokote, K, Shimizu, T |
Izuo, N, Kasahara, C, Murakami, K, Kume, T, Maeda, M, Irie, K, Yokote, K, Shimizu, T |
Naotaka Izuo, Chihiro Kasahara, Kazuma Murakami, Toshiaki Kume, Masahiro Maeda, Kazuhiro Irie, Koutaro Yokote, Takahiko Shimizu |
A toxic conformer of Aβ42 with a turn at 22-23 is a novel therapeutic target for Alzheimer’s disease |
A toxic conformer of Aβ42 with a turn at 22-23 is a novel therapeutic target for Alzheimer’s disease |
A Toxic Conformer of Aβ42 with a Turn at 22-23 is a Novel Therapeutic Target for Alzheimer's Disease. |
Sci. Rep., 7, 1, 11811-11811 |
Sci. Rep., 7, 1, 11811-11811 |
Scientific reports, 7, 1, 11811-11811 |
2017/09/18 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Y. Aihara, A. Kawaguchi, M. Hanaki, K. Murakami, K. Irie, H. Shigemori |
Y. Aihara, A. Kawaguchi, M. Hanaki, K. Murakami, K. Irie, H. Shigemori |
Yukine Aihara, Ayumi Kawaguchi, Mizuho Hanaki, Kazuma Murakami, Kazuhiro Irie, Hideyuki Shigemori |
Inhibitory activity of hispidin derivatives isolated from Inonotus obliquus on amyloid β aggregation |
Inhibitory activity of hispidin derivatives isolated from Inonotus obliquus on amyloid β aggregation |
INHIBITORY ACTIVITY OF HISPIDIN DERIVATIVES ISOLATED FROM INONOTUS OBLIQUUS ON AMYLOID beta AGGREGATION |
Heterocycles, 94, 7, 1280-1287 |
Heterocycles, 94, 7, 1280-1287 |
HETEROCYCLES, 94, 7, 1280-1287 |
2017/07 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Oku Y, Murakami K, Irie K, Hoseki J, Sakai Y |
Oku Y, Murakami K, Irie K, Hoseki J, Sakai Y |
Yuki Oku, Kazuma Murakami, Kazuhiro Irie, Jun Hoseki, Yasuyoshi Sakai |
Synthesized Aβ42 Caused Intracellular Oxidative Damage, Leading to Cell Death, via Lysosome Rupture. |
Synthesized Aβ42 Caused Intracellular Oxidative Damage, Leading to Cell Death, via Lysosome Rupture. |
Synthesized Aβ42 Caused Intracellular Oxidative Damage, Leading to Cell Death, via Lysosome Rupture. |
Cell structure and function, 42, 1, 71-79 |
Cell structure and function, 42, 1, 71-79 |
Cell structure and function, 42, 1, 71-79 |
2017/05/23 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Irie Y, Murakami K, Hanaki M, Hanaki Y, Suzuki T, Monobe Y, Takai T, Akagi KI, Kawase T, Hirose K, Irie K |
Irie Y, Murakami K, Hanaki M, Hanaki Y, Suzuki T, Monobe Y, Takai T, Akagi KI, Kawase T, Hirose K, Irie K |
Yumi Irie, Kazuma Murakami, Mizuho Hanaki, Yusuke Hanaki, Takashi Suzuki, Yoko Monobe, Tomoyo Takai, Ken-Ichi Akagi, Taiji Kawase, Kenji Hirose, Kazuhiro Irie |
Synthetic Models of Quasi-Stable Amyloid β40 Oligomers with Significant Neurotoxicity. |
Synthetic Models of Quasi-Stable Amyloid β40 Oligomers with Significant Neurotoxicity. |
Synthetic Models of Quasi-Stable Amyloid β40 Oligomers with Significant Neurotoxicity. |
ACS Chem. Neurosci., 8, 4, 807-816 |
ACS Chem. Neurosci., 8, 4, 807-816 |
ACS chemical neuroscience, 8, 4, 807-816 |
2017/04/19 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| 村上一馬, 入江一浩 |
村上一馬, 入江一浩 |
K. Murakami, K. Irie |
食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析 |
食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析 |
食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析 |
日本認知症学会誌, 31, 3, 351-360 |
日本認知症学会誌, 31, 3, 351-360 |
日本認知症学会誌, 31, 3, 351-360 |
2017 |
|
日本語 |
研究論文(学術雑誌) |
公開 |
| Asma Ben Hmidene, Mizuho Hanaki, Kazuma Murakami, Kazuhiro Irie, Hiroko Isoda, Hideyuki Shigemori |
Asma Ben Hmidene, Mizuho Hanaki, Kazuma Murakami, Kazuhiro Irie, Hiroko Isoda, Hideyuki Shigemori |
Asma Ben Hmidene, Mizuho Hanaki, Kazuma Murakami, Kazuhiro Irie, Hiroko Isoda, Hideyuki Shigemori |
Inhibitory Activities of Antioxidant Flavonoids from Tamarix gallica on Amyloid Aggregation Related to Alzheimer's and Type 2 Diabetes Diseases. |
Inhibitory Activities of Antioxidant Flavonoids from Tamarix gallica on Amyloid Aggregation Related to Alzheimer's and Type 2 Diabetes Diseases. |
Inhibitory Activities of Antioxidant Flavonoids from Tamarix gallica on Amyloid Aggregation Related to Alzheimer's and Type 2 Diabetes Diseases. |
Biological & pharmaceutical bulletin, 40, 2, 238-241 |
Biological & pharmaceutical bulletin, 40, 2, 238-241 |
Biological & pharmaceutical bulletin, 40, 2, 238-241 |
2017 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| E. Kidachi, M. Kurisu, Y. Miyamae, M. Hanaki, K. Murakami, K. Irie, H. *Shigemori |
E. Kidachi, M. Kurisu, Y. Miyamae, M. Hanaki, K. Murakami, K. Irie, H. *Shigemori |
Eri Kidachi, Manami Kurisu, Yusaku Miyamae, Mizuho Hanaki, Kazuma Murakami, Kazuhiro Irie, Hideyuki Shigemori |
Structure-activity relationship of phenylethanoid glycosides on the inhibition of amyloid β aggregation |
Structure-activity relationship of phenylethanoid glycosides on the inhibition of amyloid β aggregation |
STRUCTURE-ACTIVITY RELATIONSHIP OF PHENYLETHANOID GLYCOSIDES ON THE INHIBITION OF AMYLOID beta AGGREGATION |
Heterocycles, 92, 11, 1976-1982 |
Heterocycles, 92, 11, 1976-1982 |
HETEROCYCLES, 92, 11, 1976-1982 |
2016/11 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Yoshioka T, Murakami K, Ido K, Hanaki M, Yamaguchi K, Midorikawa S, Taniwaki S, Gunji H, Irie K |
Yoshioka T, Murakami K, Ido K, Hanaki M, Yamaguchi K, Midorikawa S, Taniwaki S, Gunji H, Irie K |
Takuya Yoshioka, Kazuma Murakami, Kyohei Ido, Mizuho Hanaki, Kanoko Yamaguchi, Satohiro Midorikawa, Shinji Taniwaki, Hiroki Gunji, Kazuhiro Irie |
Semisynthesis and Structure-Activity Studies of Uncarinic Acid C Isolated from Uncaria rhynchophylla as a Specific Inhibitor of the Nucleation Phase in Amyloid β42 Aggregation. |
Semisynthesis and Structure-Activity Studies of Uncarinic Acid C Isolated from Uncaria rhynchophylla as a Specific Inhibitor of the Nucleation Phase in Amyloid β42 Aggregation. |
Semisynthesis and Structure-Activity Studies of Uncarinic Acid C Isolated from Uncaria rhynchophylla as a Specific Inhibitor of the Nucleation Phase in Amyloid β42 Aggregation. |
Journal of natural products, 79, 10, 2521-2529 |
Journal of natural products, 79, 10, 2521-2529 |
Journal of natural products, 79, 10, 2521-2529 |
2016/10/28 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Murakami K, Tokuda M, Suzuki T, Irie Y, Hanaki M, Izuo N, Monobe Y, Akagi K, Ishii R, Tatebe H, Tokuda T, Maeda M, Kume T, Shimizu T, Irie K |
Murakami K, Tokuda M, Suzuki T, Irie Y, Hanaki M, Izuo N, Monobe Y, Akagi K, Ishii R, Tatebe H, Tokuda T, Maeda M, Kume T, Shimizu T, Irie K |
Kazuma Murakami, Maki Tokuda, Takashi Suzuki, Yumi Irie, Mizuho Hanaki, Naotaka Izuo, Yoko Monobe, Ken-Ichi Akagi, Ryotaro Ishii, Harutsugu Tatebe, Takahiko Tokuda, Masahiro Maeda, Toshiaki Kume, Takahiko Shimizu, Kazuhiro Irie |
Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis. |
Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis. |
Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis. |
Scientific Reports, 6, 29038-29038 |
Scientific Reports, 6, 29038-29038 |
Scientific reports, 6, 29038-29038 |
2016/07/04 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Hanaki, M, Murakami, K, Akagi, K, Irie, K |
Hanaki, M, Murakami, K, Akagi, K, Irie, K |
Mizuho Hanaki, Kazuma Murakami, Ken-ichi Akagi, Kazuhiro Irie |
Structural insights into mechanism for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids |
Structural insights into mechanism for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids |
Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids. |
Bioorg. Med. Chem., 24, 2, 304-13 |
Bioorg. Med. Chem., 24, 2, 304-13 |
Bioorganic & medicinal chemistry, 24, 2, 304-13 |
2016/01/15 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Murakami, K, Suzuki, T, Hanaki, M, Monobe, Y, Akagi, K, Irie, K |
Murakami, K, Suzuki, T, Hanaki, M, Monobe, Y, Akagi, K, Irie, K |
Kazuma Murakami, Takashi Suzuki, Mizuho Hanaki, Yoko Monobe, Ken-Ichi Akagi, Kazuhiro Irie |
Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region |
Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region |
Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region. |
Biochem. Biophys. Res. Commun., 466, 3, 463-7 |
Biochem. Biophys. Res. Commun., 466, 3, 463-7 |
Biochemical and biophysical research communications, 466, 3, 463-7 |
2015/10/23 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Izuo Naotaka, Kume Toshiaki, Murakami Kazuma, Irie Kazuhiro, Izumi Yasuhiko, Akaike Akinori, Yokote Koutaro, Shimizu Takahiko |
Izuo Naotaka, Kume Toshiaki, Murakami Kazuma, Irie Kazuhiro, Izumi Yasuhiko, Akaike Akinori, Yokote Koutaro, Shimizu Takahiko |
Izuo Naotaka, Kume Toshiaki, Murakami Kazuma, Irie Kazuhiro, Izumi Yasuhiko, Akaike Akinori, Yokote Koutaro, Shimizu Takahiko |
Pathophysiological activities of the "toxic conformer" and the "non-toxic conformer" of amyloid beta-induced neurotoxicity |
Pathophysiological activities of the "toxic conformer" and the "non-toxic conformer" of amyloid beta-induced neurotoxicity |
Pathophysiological activities of the "toxic conformer" and the "non-toxic conformer" of amyloid beta-induced neurotoxicity |
JOURNAL OF PHARMACOLOGICAL SCIENCES, 128, 3, S196 |
JOURNAL OF PHARMACOLOGICAL SCIENCES, 128, 3, S196 |
JOURNAL OF PHARMACOLOGICAL SCIENCES, 128, 3, S196 |
2015/07 |
有 |
|
|
公開 |
| 泉尾直孝, 村上一馬, 久米利明, 前田雅弘, 入江一浩, 清水孝彦 |
泉尾直孝, 村上一馬, 久米利明, 前田雅弘, 入江一浩, 清水孝彦 |
|
アルツハイマー病様神経毒性におけるアミロイドβコンホマーの役割 |
アルツハイマー病様神経毒性におけるアミロイドβコンホマーの役割 |
|
基礎老化研究, 39, 3, 29-34 |
基礎老化研究, 39, 3, 29-34 |
, 39, 3, 29-34 |
2015 |
|
日本語 |
研究論文(学術雑誌) |
公開 |
| Kazuma Murakami, Kazuhiro Irie, Takahiko Shimizu |
Kazuma Murakami, Kazuhiro Irie, Takahiko Shimizu |
Kazuma Murakami, Kazuhiro Irie, Takahiko Shimizu |
Potential Role of Vitamin C in the Prevention of Alzheimer's Disease |
Potential Role of Vitamin C in the Prevention of Alzheimer's Disease |
Potential Role of Vitamin C in the Prevention of Alzheimer's Disease |
Diet and Nutrition in Dementia and Cognitive Decline, 663-668 |
Diet and Nutrition in Dementia and Cognitive Decline, 663-668 |
Diet and Nutrition in Dementia and Cognitive Decline, 663-668 |
2014/11/18 |
有 |
英語 |
|
公開 |
| Izuo Naotaka, Kume Toshiaki, Murakami Kazuma, Sato Mizuho, Irie Kazuhiro, Izumi Yasuhiko, Akaike Akinori, Yokote Koutaro, Shimizu Takahiko |
Izuo Naotaka, Kume Toshiaki, Murakami Kazuma, Sato Mizuho, Irie Kazuhiro, Izumi Yasuhiko, Akaike Akinori, Yokote Koutaro, Shimizu Takahiko |
Izuo Naotaka, Kume Toshiaki, Murakami Kazuma, Sato Mizuho, Irie Kazuhiro, Izumi Yasuhiko, Akaike Akinori, Yokote Koutaro, Shimizu Takahiko |
Induction of Oxidative stress by the "toxic conformer" is crucial for A beta 42 |
Induction of Oxidative stress by the "toxic conformer" is crucial for A beta 42 |
Induction of Oxidative stress by the "toxic conformer" is crucial for A beta 42 |
JOURNAL OF PHARMACOLOGICAL SCIENCES, 124, 78P |
JOURNAL OF PHARMACOLOGICAL SCIENCES, 124, 78P |
JOURNAL OF PHARMACOLOGICAL SCIENCES, 124, 78P |
2014 |
有 |
|
|
公開 |
| Kazuma Murakami |
Kazuma Murakami |
Kazuma Murakami |
Conformation-specific antibodies to target amyloid β oligomers and their application to immunotherapy for Alzheimer’s disease. |
Conformation-specific antibodies to target amyloid β oligomers and their application to immunotherapy for Alzheimer’s disease. |
Conformation-specific antibodies to target amyloid β oligomers and their application to immunotherapy for Alzheimer's disease. |
Biosci. Biotechnol. Biochem., 78, 8, 1293-305 |
Biosci. Biotechnol. Biochem., 78, 8, 1293-305 |
Bioscience, biotechnology, and biochemistry, 78, 8, 1293-305 |
2014 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Izuo, N, Murakami, K, Sato, M, Iwasaki, M, Izumi, Y, Kinoshita, N, Akaike, A, Irie, K, Kume, T |
Izuo, N, Murakami, K, Sato, M, Iwasaki, M, Izumi, Y, Kinoshita, N, Akaike, A, Irie, K, Kume, T |
Naotaka Izuo, Kazuma Murakami, Mizuho Sato, Mami Iwasaki, Yasuhiko Izumi, Takahiko Shimizu, Akinori Akaike, Kazuhiro Irie, Toshiaki Kume |
Non-toxic conformer of Aβ42 may suppress Aβ42-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy of Alzheimer’s disease. |
Non-toxic conformer of Aβ42 may suppress Aβ42-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy of Alzheimer’s disease. |
Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease. |
Biochem. Biophys. Res. Commun., 438, 1, 1-5 |
Biochem. Biophys. Res. Commun., 438, 1, 1-5 |
Biochemical and biophysical research communications, 438, 1, 1-5 |
2013/08/16 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Sato, M, Murakami, K, Uno, M, Nakagawa, Y, Katayama, S, Akagi, K, Masuda, Y, Takegoshi, K, Irie, K |
Sato, M, Murakami, K, Uno, M, Nakagawa, Y, Katayama, S, Akagi, K, Masuda, Y, Takegoshi, K, Irie, K |
Mizuho Sato, Kazuma Murakami, Mayumi Uno, Yu Nakagawa, Sumie Katayama, Ken-ichi Akagi, Yuichi Masuda, Kiyonori Takegoshi, Kazuhiro Irie |
Site-specific inhibitory mechanism of amyloid-β42 aggregation by catechol-type flavonoids targeting the Lys residues. |
Site-specific inhibitory mechanism of amyloid-β42 aggregation by catechol-type flavonoids targeting the Lys residues. |
Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues. |
J. Biol. Chem., 288, 32, 23212-24 |
J. Biol. Chem., 288, 32, 23212-24 |
The Journal of biological chemistry, 288, 32, 23212-24 |
2013/08/09 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Hiroaki Kamachi, Keisuke Tanaka, Ryo C Yanagita, Akira Murakami, Kazuma Murakami, Harukuni Tokuda, Nobutaka Suzuki, Yu Nakagawa, Kazuhiro Irie |
Hiroaki Kamachi, Keisuke Tanaka, Ryo C Yanagita, Akira Murakami, Kazuma Murakami, Harukuni Tokuda, Nobutaka Suzuki, Yu Nakagawa, Kazuhiro Irie |
Hiroaki Kamachi, Keisuke Tanaka, Ryo C Yanagita, Akira Murakami, Kazuma Murakami, Harukuni Tokuda, Nobutaka Suzuki, Yu Nakagawa, Kazuhiro Irie |
Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity. |
Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity. |
Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity. |
Bioorganic & medicinal chemistry, 21, 10, 2695-702 |
Bioorganic & medicinal chemistry, 21, 10, 2695-702 |
Bioorganic & medicinal chemistry, 21, 10, 2695-702 |
2013/05/15 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Kondo, T, Asai, M, Tsukita, K, Kutoku, Y, Ohsawa, Y, Sunada, Y, Imamura, K, Egawa, N, Yahata, N, Okita, K, Takahashi, K, Asaka, I, Aoi, T, Watanabe, A, Watanabe, K, Kadoya, C, Nakano, R, Watanabe, D, Maruyama, K, Hori, O, Hibino, S, Choshi, T, Nakahata, T, Hioki, H, Kaneko, T, Naitoh, M, Yoshikawa, S, Yamawaki, S, Suzuki, S, Hata, R, Ueno, S, Seki, T, Kobayashi, K, Toda, T, Murakami, K, Irie, K, Klein, W. L, Mori, H, Asada, T, Takahashi, R, Iwata, N, Yamanaka, S, Inoue, H |
Kondo, T, Asai, M, Tsukita, K, Kutoku, Y, Ohsawa, Y, Sunada, Y, Imamura, K, Egawa, N, Yahata, N, Okita, K, Takahashi, K, Asaka, I, Aoi, T, Watanabe, A, Watanabe, K, Kadoya, C, Nakano, R, Watanabe, D, Maruyama, K, Hori, O, Hibino, S, Choshi, T, Nakahata, T, Hioki, H, Kaneko, T, Naitoh, M, Yoshikawa, S, Yamawaki, S, Suzuki, S, Hata, R, Ueno, S, Seki, T, Kobayashi, K, Toda, T, Murakami, K, Irie, K, Klein, W. L, Mori, H, Asada, T, Takahashi, R, Iwata, N, Yamanaka, S, Inoue, H |
Takayuki Kondo, Masashi Asai, Kayoko Tsukita, Yumiko Kutoku, Yutaka Ohsawa, Yoshihide Sunada, Keiko Imamura, Naohiro Egawa, Naoki Yahata, Keisuke Okita, Kazutoshi Takahashi, Isao Asaka, Takashi Aoi, Akira Watanabe, Kaori Watanabe, Chie Kadoya, Rie Nakano, Dai Watanabe, Kei Maruyama, Osamu Hori, Satoshi Hibino, Tominari Choshi, Tatsutoshi Nakahata, Hiroyuki Hioki, Takeshi Kaneko, Motoko Naitoh, Katsuhiro Yoshikawa, Satoko Yamawaki, Shigehiko Suzuki, Ryuji Hata, Shu-Ichi Ueno, Tsuneyoshi Seki, Kazuhiro Kobayashi, Tatsushi Toda, Kazuma Murakami, Kazuhiro Irie, William L Klein, Hiroshi Mori, Takashi Asada, Ryosuke Takahashi, Nobuhisa Iwata, Shinya Yamanaka, Haruhisa Inoue |
Modeling Alzheimer’s disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. |
Modeling Alzheimer’s disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. |
Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. |
Cell Stem Cell 12 (4), 487-496 (2013)., 12, 4, 487-96 |
Cell Stem Cell 12 (4), 487-496 (2013)., 12, 4, 487-96 |
Cell stem cell, 12, 4, 487-96 |
2013/04/04 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Kenche, V. B, Hung, L. W, Perez, K, Volitakes, I, Ciccotosto, G, Kwok, J, Critch, N, Sherratt, N, Cortes, M, Lal, V, Masters, C. L, Murakami, K, Cappai, R, Adlard, P. A, Barnham, K. J |
Kenche, V. B, Hung, L. W, Perez, K, Volitakes, I, Ciccotosto, G, Kwok, J, Critch, N, Sherratt, N, Cortes, M, Lal, V, Masters, C. L, Murakami, K, Cappai, R, Adlard, P. A, Barnham, K. J |
Vijaya B Kenche, Lin W Hung, Keyla Perez, Irene Volitakes, Guiseppe Ciccotosto, Jeffrey Kwok, Nicole Critch, Nikki Sherratt, Mikhalina Cortes, Varsha Lal, Colin L Masters, Kazuma Murakami, Roberto Cappai, Paul A Adlard, Kevin J Barnham |
Development of a platinum complex as an anti-amyloid agent for the therapy of Alzheimer’s disease. |
Development of a platinum complex as an anti-amyloid agent for the therapy of Alzheimer’s disease. |
Development of a platinum complex as an anti-amyloid agent for the therapy of Alzheimer's disease. |
Angew. Chem. Int. Ed. 52 (12), 3374-3378 (2013)., 52, 12, 3374-8 |
Angew. Chem. Int. Ed. 52 (12), 3374-3378 (2013)., 52, 12, 3374-8 |
Angewandte Chemie (International ed. in English), 52, 12, 3374-8 |
2013/03/18 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Sato M, Murakami K, Uno M, Ikubo H, Nakagawa Y, Katayama S, Akagi K, Irie K |
Sato M, Murakami K, Uno M, Ikubo H, Nakagawa Y, Katayama S, Akagi K, Irie K |
Mizuho Sato, Kazuma Murakami, Mayumi Uno, Haruko Ikubo, Yu Nakagawa, Sumie Katayama, Ken-Ichi Akagi, Kazuhiro Irie |
Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation. |
Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation. |
Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation. |
Bioscience, biotechnology, and biochemistry, 77, 5, 1100-3 |
Bioscience, biotechnology, and biochemistry, 77, 5, 1100-3 |
Bioscience, biotechnology, and biochemistry, 77, 5, 1100-3 |
2013 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Kurisu M, Miyamae Y, Murakami K, Han J, Isoda H, Irie K, Shigemori H |
Kurisu M, Miyamae Y, Murakami K, Han J, Isoda H, Irie K, Shigemori H |
Manami Kurisu, Yusaku Miyamae, Kazuma Murakami, Junkyu Han, Hiroko Isoda, Kazuhiro Irie, Hideyuki Shigemori |
Inhibition of amyloid β aggregation by acteoside, a phenylethanoid glycoside. |
Inhibition of amyloid β aggregation by acteoside, a phenylethanoid glycoside. |
Inhibition of amyloid β aggregation by acteoside, a phenylethanoid glycoside. |
Bioscience, biotechnology, and biochemistry, 77, 6, 1329-32 |
Bioscience, biotechnology, and biochemistry, 77, 6, 1329-32 |
Bioscience, biotechnology, and biochemistry, 77, 6, 1329-32 |
2013 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Soejima, N, Ohyagi, Y, Nakamura, N, Himeno, E, Iimura, K. M, Sakae, N, Yamasaki, R, Tabira, T, Murakami, K, Irie, K, Kinoshita, N, LaFerla, F. M, Kiyohara, Y, Iwaki, T, Kira, J |
Soejima, N, Ohyagi, Y, Nakamura, N, Himeno, E, Iimura, K. M, Sakae, N, Yamasaki, R, Tabira, T, Murakami, K, Irie, K, Kinoshita, N, LaFerla, F. M, Kiyohara, Y, Iwaki, T, Kira, J |
Naoko Soejima, Yasumasa Ohyagi, Norimichi Nakamura, Eri Himeno, Kyoko M Iinuma, Nobutaka Sakae, Ryo Yamasaki, Takeshi Tabira, Kazuma Murakami, Kazuhiro Irie, Noriaki Kinoshita, Frank M LaFerla, Yutaka Kiyohara, Toru Iwaki, Jun-ichi Kira |
Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease. |
Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease. |
Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease. |
Curr. Alzheimer Res., 10, 1, 11-20 |
Curr. Alzheimer Res., 10, 1, 11-20 |
Current Alzheimer research, 10, 1, 11-20 |
2013/01 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Kulic, L, McAfoose, J, Welt, T, Tackenberg, C, Spani, C, Wirth, F, Finder, V, Konietzko, U, Giese, M, Eckert, A, Kinoshita, N, Shimizu, T, Murakami, K, Irie, K, Rasool, S, Glabe, C, Hock, C, Nitsch, R |
Kulic, L, McAfoose, J, Welt, T, Tackenberg, C, Spani, C, Wirth, F, Finder, V, Konietzko, U, Giese, M, Eckert, A, Kinoshita, N, Shimizu, T, Murakami, K, Irie, K, Rasool, S, Glabe, C, Hock, C, Nitsch, R |
L. Kulic, J. McAfoose, T. Welt, C. Tackenberg, C. Spaeni, F. Wirth, V. Finder, U. Konietzko, M. Giese, A. Eckert, K. Noriaki, T. Shimizu, K. Murakami, K. Irie, S. Rasool, C. Glabe, C. Hock, R. M. Nitsch |
Early accumulation of intracellular finrillar oligomers and late congophilic amyloid angiopathy in mice overexpressing the Osaka intra-Aβ APP mutation. |
Early accumulation of intracellular finrillar oligomers and late congophilic amyloid angiopathy in mice overexpressing the Osaka intra-Aβ APP mutation. |
Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-A beta APP mutation |
Transl. Psychiatry 2012, 2, e183 (2012)., 2 |
Transl. Psychiatry 2012, 2, e183 (2012)., 2 |
TRANSLATIONAL PSYCHIATRY, 2 |
2012/11 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Y. Miyamae, M. Kurisu, K. Murakami, J. Han, H. Isoda, K. Irie, H. Shigemori |
Y. Miyamae, M. Kurisu, K. Murakami, J. Han, H. Isoda, K. Irie, H. Shigemori |
Yusaku Miyamae, Manami Kurisu, Kazuma Murakami, Junkyu Han, Hiroko Isoda, Kazuhiro Irie, Hideyuki Shigemori |
Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein |
Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein |
Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein. |
Bioorg. Med. Chem., 20, 19, 5844-9 |
Bioorg. Med. Chem., 20, 19, 5844-9 |
Bioorganic & medicinal chemistry, 20, 19, 5844-9 |
2012/10/01 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Miyamae, Y, Kurisu, M, Murakami, K, Han, J, Isoda, H, Irie, K, Shigemori, H |
Miyamae, Y, Kurisu, M, Murakami, K, Han, J, Isoda, H, Irie, K, Shigemori, H |
Miyamae, Y, Kurisu, M, Murakami, K, Han, J, Isoda, H, Irie, K, Shigemori, H |
Caffeoylquinic acids inhibit amyloid β fibril formation and cellular toxicity. |
Caffeoylquinic acids inhibit amyloid β fibril formation and cellular toxicity. |
Caffeoylquinic acids inhibit amyloid β fibril formation and cellular toxicity. |
Bioorg. Med. Chem. 19 (1), 5844-5849 (2012)., 20, 19, 5844-5849 |
Bioorg. Med. Chem. 19 (1), 5844-5849 (2012)., 20, 19, 5844-5849 |
Bioorg. Med. Chem. 19 (1), 5844-5849 (2012)., 20, 19, 5844-5849 |
2012/10 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Izuo, N, Kume, T, Sato, M, Murakami, K, Irie, K, Izumi Y, Akaike, A |
Izuo, N, Kume, T, Sato, M, Murakami, K, Irie, K, Izumi Y, Akaike, A |
Naotaka Izuo, Toshiaki Kume, Mizuho Sato, Kazuma Murakami, Kazuhiro Irie, Yasuhiko Izumi, Akinori Akaike |
Toxicity in rat primary neuron through the cellular oxidative stress induced by the turn formation 22 and 23 of Aβ42. |
Toxicity in rat primary neuron through the cellular oxidative stress induced by the turn formation 22 and 23 of Aβ42. |
Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42. |
ACS Chem. Neurosci. 3 (9), 674-681 (2012)., 3, 9, 674-81 |
ACS Chem. Neurosci. 3 (9), 674-681 (2012)., 3, 9, 674-81 |
ACS chemical neuroscience, 3, 9, 674-81 |
2012/09/19 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Izuo N, Kume T, Sato M, Murakami K, Irie K, Izumi Y, Akaike A |
Izuo N, Kume T, Sato M, Murakami K, Irie K, Izumi Y, Akaike A |
Naotaka Izuo, Toshiaki Kume, Mizuho Sato, Kazuma Murakami, Kazuhiro Irie, Yasuhiko Izumi, Akinori Akaike |
Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42. |
Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42. |
Toxicity in Rat Primary Neurons through the Cellular Oxidative Stress Induced by the Turn Formation at Positions 22 and 23 of A beta 42 |
ACS chemical neuroscience, 3, 9, 674-681 |
ACS chemical neuroscience, 3, 9, 674-681 |
ACS CHEMICAL NEUROSCIENCE, 3, 9, 674-681 |
2012/09 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Murakami K, Shimizu T |
Murakami K, Shimizu T |
Kazuma Murakami, Takahiko Shimizu |
Cytoplasmic superoxide radical: a possible contributing factor to intracellular Aβ oligomerization in Alzheimer disease. |
Cytoplasmic superoxide radical: a possible contributing factor to intracellular Aβ oligomerization in Alzheimer disease. |
Cytoplasmic superoxide radical: a possible contributing factor to intracellular Aβ oligomerization in Alzheimer disease. |
Communicative & integrative biology, 5, 3, 255-8 |
Communicative & integrative biology, 5, 3, 255-8 |
Communicative & integrative biology, 5, 3, 255-8 |
2012/05/01 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Fumitada Tsuji, Ayako Ishihara, Keiko Kurata, Aya Nakagawa, Masahiro Okada, Shigeyuki Kitamura, Kyoko Kanamaru, Yuichi Masuda, Kazuma Murakami, Kazuhiro Irie, Youji Sakagami |
Fumitada Tsuji, Ayako Ishihara, Keiko Kurata, Aya Nakagawa, Masahiro Okada, Shigeyuki Kitamura, Kyoko Kanamaru, Yuichi Masuda, Kazuma Murakami, Kazuhiro Irie, Youji Sakagami |
Fumitada Tsuji, Ayako Ishihara, Keiko Kurata, Aya Nakagawa, Masahiro Okada, Shigeyuki Kitamura, Kyoko Kanamaru, Yuichi Masuda, Kazuma Murakami, Kazuhiro Irie, Youji Sakagami |
Geranyl modification on the tryptophan residue of ComXRO-E-2 pheromone by a cell-free system. |
Geranyl modification on the tryptophan residue of ComXRO-E-2 pheromone by a cell-free system. |
Geranyl modification on the tryptophan residue of ComXRO-E-2 pheromone by a cell-free system. |
FEBS letters, 586, 2, 174-9 |
FEBS letters, 586, 2, 174-9 |
FEBS letters, 586, 2, 174-9 |
2012/01/20 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Fumitada Tsuji, Ayako Ishihara, Aya Nakagawa, Masahiro Okada, Shigeyuki Kitamura, Kyoko Kanamaru, Yuichi Masuda, Kazuma Murakami, Kazuhiro Irie, Youji Sakagami |
Fumitada Tsuji, Ayako Ishihara, Aya Nakagawa, Masahiro Okada, Shigeyuki Kitamura, Kyoko Kanamaru, Yuichi Masuda, Kazuma Murakami, Kazuhiro Irie, Youji Sakagami |
Fumitada Tsuji, Ayako Ishihara, Aya Nakagawa, Masahiro Okada, Shigeyuki Kitamura, Kyoko Kanamaru, Yuichi Masuda, Kazuma Murakami, Kazuhiro Irie, Youji Sakagami |
Lack of the consensus sequence necessary for tryptophan prenylation in the ComX pheromone precursor. |
Lack of the consensus sequence necessary for tryptophan prenylation in the ComX pheromone precursor. |
Lack of the consensus sequence necessary for tryptophan prenylation in the ComX pheromone precursor. |
Bioscience, biotechnology, and biochemistry, 76, 8, 1492-6 |
Bioscience, biotechnology, and biochemistry, 76, 8, 1492-6 |
Bioscience, biotechnology, and biochemistry, 76, 8, 1492-6 |
2012 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Izuo Naotaka, Kume Toshiaki, Sato Mizuho, Murakami Kazuma, Irie Kazuhiro, Izumi Yasuhiko, Akaike Akinori |
Izuo Naotaka, Kume Toshiaki, Sato Mizuho, Murakami Kazuma, Irie Kazuhiro, Izumi Yasuhiko, Akaike Akinori |
Izuo Naotaka, Kume Toshiaki, Sato Mizuho, Murakami Kazuma, Irie Kazuhiro, Izumi Yasuhiko, Akaike Akinori |
Crucial role of the turn at positions 22-23 in neurotoxicity of amyloid beta |
Crucial role of the turn at positions 22-23 in neurotoxicity of amyloid beta |
Crucial role of the turn at positions 22-23 in neurotoxicity of amyloid beta |
JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 62P |
JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 62P |
JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 62P |
2012 |
有 |
|
|
公開 |
| 村上一馬, 入江一浩 |
村上一馬, 入江一浩 |
|
Aβの毒性ターン構造を認識する抗体 |
Aβの毒性ターン構造を認識する抗体 |
|
神経内科, 77, 179-184 |
神経内科, 77, 179-184 |
, 77, 179-184 |
2012 |
|
日本語 |
研究論文(学術雑誌) |
公開 |
| 村上一馬, 佐藤瑞穂, 鈴木啓之, 泉尾直孝, 久米利明, 赤池昭紀, 永田 徹, 西崎知之, 富山貴美, 森 啓, 入江一浩 |
村上一馬, 佐藤瑞穂, 鈴木啓之, 泉尾直孝, 久米利明, 赤池昭紀, 永田 徹, 西崎知之, 富山貴美, 森 啓, 入江一浩 |
|
アミロイドβの「毒性コンホマー」形成とGlu22位における遺伝性変異 |
アミロイドβの「毒性コンホマー」形成とGlu22位における遺伝性変異 |
アミロイドβの「毒性コンホマー」形成とGlu22位における遺伝性変異 |
Dementia Japan, 26, 3, 311-318 |
Dementia Japan, 26, 3, 311-318 |
Dementia Japan,, 26, 3, 311-318 |
2012 |
|
日本語 |
研究論文(学術雑誌) |
公開 |
| Sayo Ueno, Ryo C Yanagita, Kazuma Murakami, Akira Murakami, Harukuni Tokuda, Nobutaka Suzuki, Takeshi Fujiwara, Kazuhiro Irie |
Sayo Ueno, Ryo C Yanagita, Kazuma Murakami, Akira Murakami, Harukuni Tokuda, Nobutaka Suzuki, Takeshi Fujiwara, Kazuhiro Irie |
Sayo Ueno, Ryo C Yanagita, Kazuma Murakami, Akira Murakami, Harukuni Tokuda, Nobutaka Suzuki, Takeshi Fujiwara, Kazuhiro Irie |
Identification and biological activities of bryostatins from Japanese bryozoan. |
Identification and biological activities of bryostatins from Japanese bryozoan. |
Identification and biological activities of bryostatins from Japanese bryozoan. |
Bioscience, biotechnology, and biochemistry, 76, 5, 1041-3 |
Bioscience, biotechnology, and biochemistry, 76, 5, 1041-3 |
Bioscience, biotechnology, and biochemistry, 76, 5, 1041-3 |
2012 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Tsuji, F, Ishihara, A, Kurata, K, Nakagawa, A, Okada, M, Kitamura, S, Kanamaru, K, Masuda, Y, Murakami, K, Irie, K, Sakagami, Y |
Tsuji, F, Ishihara, A, Kurata, K, Nakagawa, A, Okada, M, Kitamura, S, Kanamaru, K, Masuda, Y, Murakami, K, Irie, K, Sakagami, Y |
Tsuji, F, Ishihara, A, Kurata, K, Nakagawa, A, Okada, M, Kitamura, S, Kanamaru, K, Masuda, Y, Murakami, K, Irie, K, Sakagami, Y |
ComX pheromone precursor contains no consensus sequence necessary for tryptophan prenylation. |
ComX pheromone precursor contains no consensus sequence necessary for tryptophan prenylation. |
ComX pheromone precursor contains no consensus sequence necessary for tryptophan prenylation. |
Biosci. Biotechnol. Biochem. 76 (8), 1492-1496 (2012)., 76, 8, 1492-1496 |
Biosci. Biotechnol. Biochem. 76 (8), 1492-1496 (2012)., 76, 8, 1492-1496 |
Biosci. Biotechnol. Biochem. 76 (8), 1492-1496 (2012)., 76, 8, 1492-1496 |
2012 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Murakami, K, Murata, N, Noda, Y, Irie, K, Shirasawa, T, Shimizu, T |
Murakami, K, Murata, N, Noda, Y, Irie, K, Shirasawa, T, Shimizu, T |
Kazuma Murakami, Nakaba Murata, Yoshihiro Noda, Kazuhiro Irie, Takuji Shirasawa, Takahiko Shimizu |
Stimulation of the amyloidogenic pathway by cytoplasmic superoxide radicals in an Alzheimer’s disease mouse model |
Stimulation of the amyloidogenic pathway by cytoplasmic superoxide radicals in an Alzheimer’s disease mouse model |
Stimulation of the amyloidogenic pathway by cytoplasmic superoxide radicals in an Alzheimer's disease mouse model. |
Biosci. Biotechnol. Biochem. 76 (6), 1098-1103 (2012)., 76, 6, 1098-103 |
Biosci. Biotechnol. Biochem. 76 (6), 1098-1103 (2012)., 76, 6, 1098-103 |
Bioscience, biotechnology, and biochemistry, 76, 6, 1098-103 |
2012 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Rosensweig, C. Ono, K, Murakami, K, Lowenstein, D, Bitan, G, Teplow, D. B |
Rosensweig, C. Ono, K, Murakami, K, Lowenstein, D, Bitan, G, Teplow, D. B |
Clark Rosensweig, Kenjiro Ono, Kazuma Murakami, Devin K Lowenstein, Gal Bitan, David B Teplow |
Preparation of stable amyloid β-protein oligomers of defined assembly order. |
Preparation of stable amyloid β-protein oligomers of defined assembly order. |
Preparation of stable amyloid β-protein oligomers of defined assembly order. |
Methods. Mol. Biol. 849, 23-31 (2012)., 849, 23-31 |
Methods. Mol. Biol. 849, 23-31 (2012)., 849, 23-31 |
Methods in molecular biology (Clifton, N.J.), 849, 23-31 |
2012 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Murakami K, Murata N, Noda Y, Tahara S, Kaneko T, Kinoshita N, Hatsuta H, Murayama S, Barnham KJ, Irie K, Shirasawa T, Shimizu T |
Murakami K, Murata N, Noda Y, Tahara S, Kaneko T, Kinoshita N, Hatsuta H, Murayama S, Barnham KJ, Irie K, Shirasawa T, Shimizu T |
Kazuma Murakami, Nakaba Murata, Yoshihiro Noda, Shoichi Tahara, Takao Kaneko, Noriaki Kinoshita, Hiroyuki Hatsuta, Shigeo Murayama, Kevin J Barnham, Kazuhiro Irie, Takuji Shirasawa, Takahiko Shimizu |
SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease. |
SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease. |
SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease. |
The Journal of biological chemistry, 286, 52, 44557-68 |
The Journal of biological chemistry, 286, 52, 44557-68 |
The Journal of biological chemistry, 286, 52, 44557-68 |
2011/12/30 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Irie K, Murakami K, Masuda Y, Murata N, Noda Y, Hatsuta H, Murayama S, Shimizu T, Horikoshi Y, Kinoshita N, Shirasawa T |
Irie K, Murakami K, Masuda Y, Murata N, Noda Y, Hatsuta H, Murayama S, Shimizu T, Horikoshi Y, Kinoshita N, Shirasawa T |
Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Nakaba Murata, Yoshihiro Noda, Hiroyuki Hatsuta, Shigeo Murayama, Takahiko Shimizu, Yuko Horikoshi, Noriaki Kinoshita, Takuji Shirasawa |
[Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23]. |
[Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23]. |
[Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23]. |
Rinsho shinkeigaku = Clinical neurology, 51, 11, 890-1 |
Rinsho shinkeigaku = Clinical neurology, 51, 11, 890-1 |
Rinsho shinkeigaku = Clinical neurology, 51, 11, 890-1 |
2011/11 |
有 |
日本語 |
研究論文(学術雑誌) |
公開 |
| Kazuma Murakami, Shin-ichi Yokoyama, Nakaba Murata, Yusuke Ozawa, Kazuhiro Irie, Takuji Shirasawa, Takahiko Shimizu |
Kazuma Murakami, Shin-ichi Yokoyama, Nakaba Murata, Yusuke Ozawa, Kazuhiro Irie, Takuji Shirasawa, Takahiko Shimizu |
Kazuma Murakami, Shin-ichi Yokoyama, Nakaba Murata, Yusuke Ozawa, Kazuhiro Irie, Takuji Shirasawa, Takahiko Shimizu |
Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice |
Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice |
Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 409, 1, 34-39 |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 409, 1, 34-39 |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 409, 1, 34-39 |
2011/05 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Murakami K, Shimizu T, Irie K |
Murakami K, Shimizu T, Irie K |
Kazuma Murakami, Takahiko Shimizu, Kazuhiro Irie |
Formation of the 42-mer Amyloid β Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer's Disease. |
Formation of the 42-mer Amyloid β Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer's Disease. |
Formation of the 42-mer Amyloid β Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer's Disease. |
Journal of amino acids, 2011, 654207-654207 |
Journal of amino acids, 2011, 654207-654207 |
Journal of amino acids, 2011, 654207-654207 |
2011 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Murakami, K, Murata, N, Ozawa, Y, Kinoshita, N, Irie, K, Shirasawa, T, Shimizu, T |
Murakami, K, Murata, N, Ozawa, Y, Kinoshita, N, Irie, K, Shirasawa, T, Shimizu, T |
Kazuma Murakami, Nakaba Murata, Yusuke Ozawa, Noriaki Kinoshita, Kazuhiro Irie, Takuji Shirasawa, Takahiko Shimizu |
Vitamin C restores behavioral deficits and amyloid-β oligomerization without affecting plaque formation in a mouse model of Alzheimer's disease. |
Vitamin C restores behavioral deficits and amyloid-β oligomerization without affecting plaque formation in a mouse model of Alzheimer's disease. |
Vitamin C restores behavioral deficits and amyloid-β oligomerization without affecting plaque formation in a mouse model of Alzheimer's disease. |
J. Alzheimers Dis. 26 (1), 7-18 (2011)., 26, 1, 7-18 |
J. Alzheimers Dis. 26 (1), 7-18 (2011)., 26, 1, 7-18 |
Journal of Alzheimer's disease : JAD, 26, 1, 7-18 |
2011 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Suzuki, T, Murakami, K, Izuo, N, Kume, T, Akaike, A, Nagata, T, Nishizaki, T, Tomiyama, T, Takuma, H, Mori, H, Irie, K |
Suzuki, T, Murakami, K, Izuo, N, Kume, T, Akaike, A, Nagata, T, Nishizaki, T, Tomiyama, T, Takuma, H, Mori, H, Irie, K |
Takayuki Suzuki, Kazuma Murakami, Naotaka Izuo, Toshiaki Kume, Akinori Akaike, Tetsu Nagata, Tomoyuki Nishizaki, Takami Tomiyama, Hiroshi Takuma, Hiroshi Mori, Kazuhiro Irie |
E22Δ mutation in amyloid β-protein promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity. |
E22Δ mutation in amyloid β-protein promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity. |
E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity. |
Int. J. Alzheimers Dis. 2011, doi:10.4061/2011/431320 (2011)., 2011, 431320-431320 |
Int. J. Alzheimers Dis. 2011, doi:10.4061/2011/431320 (2011)., 2011, 431320-431320 |
International journal of Alzheimer's disease, 2011, 431320-431320 |
2010/12/19 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Murakami, K, Horikoshi-Sakuraba, Y, Murata, N, Noda, Y. Masuda, Y, Kinoshita, N, Hatsuta, H, Murayama, S, Shirasawa, T, Shimizu, T, Irie, K |
Murakami, K, Horikoshi-Sakuraba, Y, Murata, N, Noda, Y. Masuda, Y, Kinoshita, N, Hatsuta, H, Murayama, S, Shirasawa, T, Shimizu, T, Irie, K |
Kazuma Murakami, Yuko Horikoshi-Sakuraba, Nakaba Murata, Yoshihiro Noda, Yuichi Masuda, Noriaki Kinoshita, Hiroyuki Hatsuta, Shigeo Murayama, Takuji Shirasawa, Takahiko Shimizu, Kazuhiro Irie |
Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23. |
Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23. |
Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23. |
ACS Chem. Neurosci. 1 (11), 747-756 (2010)., 1, 11, 747-56 |
ACS Chem. Neurosci. 1 (11), 747-756 (2010)., 1, 11, 747-56 |
ACS chemical neuroscience, 1, 11, 747-56 |
2010/11/17 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Kazuma Murakami, Yuichi Masuda, Takuji Shirasawa, Takahiko Shimizu, Kazuhiro Irie |
Kazuma Murakami, Yuichi Masuda, Takuji Shirasawa, Takahiko Shimizu, Kazuhiro Irie |
Kazuma Murakami, Yuichi Masuda, Takuji Shirasawa, Takahiko Shimizu, Kazuhiro Irie |
The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide: the emerging role in the pathogenesis of Alzheimer's disease. |
The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide: the emerging role in the pathogenesis of Alzheimer's disease. |
The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide: the emerging role in the pathogenesis of Alzheimer's disease. |
Geriatrics & gerontology international, 10 Suppl 1, S169-79-S179 |
Geriatrics & gerontology international, 10 Suppl 1, S169-79-S179 |
Geriatrics & gerontology international, 10 Suppl 1, S169-79-S179 |
2010/07 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Murata N, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T |
Murata N, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T |
Nakaba Murata, Kazuma Murakami, Yusuke Ozawa, Noriaki Kinoshita, Kazuhiro Irie, Takuji Shirasawa, Takahiko Shimizu |
Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model. |
Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model. |
Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model. |
Bioscience, biotechnology, and biochemistry, 74, 11, 2299-306 |
Bioscience, biotechnology, and biochemistry, 74, 11, 2299-306 |
Bioscience, biotechnology, and biochemistry, 74, 11, 2299-306 |
2010 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Rahimi, F, Murakami, K, Summers, J. L, Chen, C. B, Bitan, G |
Rahimi, F, Murakami, K, Summers, J. L, Chen, C. B, Bitan, G |
Farid Rahimi, Kazuma Murakami, Jamie L Summers, Chi-Hong B Chen, Gal Bitan |
RNA aptamers generated against oligomeric Aβ40 recognize common amyloid aptatopes with low specificity but high sensitivity. |
RNA aptamers generated against oligomeric Aβ40 recognize common amyloid aptatopes with low specificity but high sensitivity. |
RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity. |
PLoS ONE 4 (11), e7694 (2009)., 4, 11, e7694 |
PLoS ONE 4 (11), e7694 (2009)., 4, 11, e7694 |
PloS one, 4, 11, e7694 |
2009/11/10 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Kazuma Murakami, Jun Inagaki, Mitsuru Saito, Yasutaka Ikeda, Chizuru Tsuda, Yoshihiro Noda, Satoru Kawakami, Takuji Shirasawa, Takahiko Shimizu |
Kazuma Murakami, Jun Inagaki, Mitsuru Saito, Yasutaka Ikeda, Chizuru Tsuda, Yoshihiro Noda, Satoru Kawakami, Takuji Shirasawa, Takahiko Shimizu |
Kazuma Murakami, Jun Inagaki, Mitsuru Saito, Yasutaka Ikeda, Chizuru Tsuda, Yoshihiro Noda, Satoru Kawakami, Takuji Shirasawa, Takahiko Shimizu |
Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative. |
Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative. |
Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative. |
Biochemical and biophysical research communications, 382, 2, 457-61 |
Biochemical and biophysical research communications, 382, 2, 457-61 |
Biochemical and biophysical research communications, 382, 2, 457-61 |
2009/05/01 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Kazuma Murakami, Mayumi Uno, Yuichi Masuda, Takahiko Shimizu, Takuji Shirasawa, Kazuhiro Irie |
Kazuma Murakami, Mayumi Uno, Yuichi Masuda, Takahiko Shimizu, Takuji Shirasawa, Kazuhiro Irie |
Kazuma Murakami, Mayumi Uno, Yuichi Masuda, Takahiko Shimizu, Takuji Shirasawa, Kazuhiro Irie |
Isomerization and/or racemization at Asp23 of Abeta42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro. |
Isomerization and/or racemization at Asp23 of Abeta42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro. |
Isomerization and/or racemization at Asp23 of Abeta42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro. |
Biochemical and biophysical research communications, 366, 3, 745-51 |
Biochemical and biophysical research communications, 366, 3, 745-51 |
Biochemical and biophysical research communications, 366, 3, 745-51 |
2008/02/15 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Murakami, K, Uno, M, Masuda, Y, Shimizu, T, Shirasawa, T, Irie, K |
Murakami, K, Uno, M, Masuda, Y, Shimizu, T, Shirasawa, T, Irie, K |
Kazuma Murakami, Mayumi Uno, Yuichi Masuda, Takahiko Shimizu, Takuji Shirasawa, Kazuhiro Irie |
Isomerization and/or racemization at Asp23 of Aβ42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro. |
Isomerization and/or racemization at Asp23 of Aβ42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro. |
Isomerization and/or racemization at Asp23 of A beta 42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro |
Biochem. Biophys. Res. Commun. 366 (3), 745-751 (2008)., 366, 3, 745-751 |
Biochem. Biophys. Res. Commun. 366 (3), 745-751 (2008)., 366, 3, 745-751 |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 366, 3, 745-751 |
2008/02 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| 村上 一馬, 清水 孝彦, 白澤 卓二, 入江 一浩 |
村上 一馬, 清水 孝彦, 白澤 卓二, 入江 一浩 |
|
βアミロイドの毒性コンホメーション |
βアミロイドの毒性コンホメーション |
|
化学と生物, 46, 6, 431-434 |
化学と生物, 46, 6, 431-434 |
, 46, 6, 431-434 |
2008 |
有 |
日本語 |
研究論文(学術雑誌) |
公開 |
| 村上 一馬, 清水 孝彦, 白澤 卓二, 入江 一浩 |
村上 一馬, 清水 孝彦, 白澤 卓二, 入江 一浩 |
|
アミロイドβ (Aβ42) の毒性コンホメーションの提唱 |
アミロイドβ (Aβ42) の毒性コンホメーションの提唱 |
|
基礎老化研究, 32, 3, 25-29 |
基礎老化研究, 32, 3, 25-29 |
, 32, 3, 25-29 |
2008 |
有 |
|
|
公開 |
| Kazuma Murakami, Hideyuki Hara, Yuichi Masuda, Hajime Ohigashi, Kazuhiro Irie |
Kazuma Murakami, Hideyuki Hara, Yuichi Masuda, Hajime Ohigashi, Kazuhiro Irie |
Kazuma Murakami, Hideyuki Hara, Yuichi Masuda, Hajime Ohigashi, Kazuhiro Irie |
Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40. |
Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40. |
Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40. |
Chembiochem : a European journal of chemical biology, 8, 18, 2308-14 |
Chembiochem : a European journal of chemical biology, 8, 18, 2308-14 |
Chembiochem : a European journal of chemical biology, 8, 18, 2308-14 |
2007/12/17 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| K. Irie, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, H. Hara, R. Ohashi, K. Takegoshi, H. Fukuda, M. Nagao, T. Shimizu, T. Shirasawa |
K. Irie, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, H. Hara, R. Ohashi, K. Takegoshi, H. Fukuda, M. Nagao, T. Shimizu, T. Shirasawa |
K. Irie, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, H. Hara, R. Ohashi, K. Takegoshi, H. Fukuda, M. Nagao, T. Shimizu, T. Shirasawa |
The toxic conformation of the 42-residue amyloid β peptide and Its relevance to oxidative stress in alzheimer's disease |
The toxic conformation of the 42-residue amyloid β peptide and Its relevance to oxidative stress in alzheimer's disease |
The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimer's disease |
Mini-Rev. Med. Chem., 7, 10, 1001-1008 |
Mini-Rev. Med. Chem., 7, 10, 1001-1008 |
Mini-Reviews in Medicinal Chemistry, 7, 10, 1001-1008 |
2007/10 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Yuichi Masuda, Kazuhiro Irie, Kazuma Murakami, Hajime Ohigashi, Ryutaro Ohashi, K Takegoshi, Takahiko Shimizu, Takuji Shirasawa |
Yuichi Masuda, Kazuhiro Irie, Kazuma Murakami, Hajime Ohigashi, Ryutaro Ohashi, K Takegoshi, Takahiko Shimizu, Takuji Shirasawa |
Yuichi Masuda, Kazuhiro Irie, Kazuma Murakami, Hajime Ohigashi, Ryutaro Ohashi, K Takegoshi, Takahiko Shimizu, Takuji Shirasawa |
Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR. |
Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR. |
Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR. |
Bioorganic & medicinal chemistry, 13, 24, 6803-9 |
Bioorganic & medicinal chemistry, 13, 24, 6803-9 |
Bioorganic & medicinal chemistry, 13, 24, 6803-9 |
2005/12/15 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Masuda, Y, Irie, K, Murakami, K, Ohigashi, H, Ohashi, R, Takegoshi, K, Shimizu, T, Shirasawa, T |
Masuda, Y, Irie, K, Murakami, K, Ohigashi, H, Ohashi, R, Takegoshi, K, Shimizu, T, Shirasawa, T |
Y Masuda, K Irie, K Murakami, H Ohigashi, R Ohashi, K Takegoshi, T Shimizu, T Shirasawa |
Verification of the turn at positions 22 and 23 of the β-amyloid fibrils with Italian mutation using solid-state NMR. |
Verification of the turn at positions 22 and 23 of the β-amyloid fibrils with Italian mutation using solid-state NMR. |
Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR |
Bioorg. Med. Chem. 13 (24), 6803-6809 (2005)., 13, 24, 6803-6809 |
Bioorg. Med. Chem. 13 (24), 6803-6809 (2005)., 13, 24, 6803-6809 |
BIOORGANIC & MEDICINAL CHEMISTRY, 13, 24, 6803-6809 |
2005/12 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Kazuma Murakami, Kazuhiro Irie, Hajime Ohigashi, Hideyuki Hara, Masaya Nagao, Takahiko Shimizu, Takuji Shirasawa |
Kazuma Murakami, Kazuhiro Irie, Hajime Ohigashi, Hideyuki Hara, Masaya Nagao, Takahiko Shimizu, Takuji Shirasawa |
Kazuma Murakami, Kazuhiro Irie, Hajime Ohigashi, Hideyuki Hara, Masaya Nagao, Takahiko Shimizu, Takuji Shirasawa |
Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease. |
Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease. |
Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease. |
Journal of the American Chemical Society, 127, 43, 15168-74 |
Journal of the American Chemical Society, 127, 43, 15168-74 |
Journal of the American Chemical Society, 127, 43, 15168-74 |
2005/11/02 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Akira Morimoto, Hajime Ohigashi, Ryutaro Ohashi, Kiyonori Takegoshi, Masaya Nagao, Takahiko Shimizu, Takuji Shirasawa |
Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Akira Morimoto, Hajime Ohigashi, Ryutaro Ohashi, Kiyonori Takegoshi, Masaya Nagao, Takahiko Shimizu, Takuji Shirasawa |
Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Akira Morimoto, Hajime Ohigashi, Ryutaro Ohashi, Kiyonori Takegoshi, Masaya Nagao, Takahiko Shimizu, Takuji Shirasawa |
Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease. |
Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease. |
Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease. |
Journal of bioscience and bioengineering, 99, 5, 437-47 |
Journal of bioscience and bioengineering, 99, 5, 437-47 |
Journal of bioscience and bioengineering, 99, 5, 437-47 |
2005/05 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Akira Morimoto, Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Hajime Ohigashi, Masaya Nagao, Hiroyuki Fukuda, Takahiko Shimizu, Takuji Shirasawa |
Akira Morimoto, Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Hajime Ohigashi, Masaya Nagao, Hiroyuki Fukuda, Takahiko Shimizu, Takuji Shirasawa |
Akira Morimoto, Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Hajime Ohigashi, Masaya Nagao, Hiroyuki Fukuda, Takahiko Shimizu, Takuji Shirasawa |
Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement. |
Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement. |
Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement. |
The Journal of biological chemistry, 279, 50, 52781-8 |
The Journal of biological chemistry, 279, 50, 52781-8 |
The Journal of biological chemistry, 279, 50, 52781-8 |
2004/12/10 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Kazuma Murakami, Kazuhiro Irie, Akira Morimoto, Hajime Ohigashi, Mayumi Shindo, Masaya Nagao, Takahiko Shimizu, Takuji Shirasawa |
Kazuma Murakami, Kazuhiro Irie, Akira Morimoto, Hajime Ohigashi, Mayumi Shindo, Masaya Nagao, Takahiko Shimizu, Takuji Shirasawa |
Kazuma Murakami, Kazuhiro Irie, Akira Morimoto, Hajime Ohigashi, Mayumi Shindo, Masaya Nagao, Takahiko Shimizu, Takuji Shirasawa |
Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease. |
Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease. |
Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease. |
The Journal of biological chemistry, 278, 46, 46179-87 |
The Journal of biological chemistry, 278, 46, 46179-87 |
The Journal of biological chemistry, 278, 46, 46179-87 |
2003/11/14 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Murakami, K, Irie, K, Morimoto, A, Ohigashi, H, Shindo, M, Nagao, M, Shimizu, T, Shirasawa, T |
Murakami, K, Irie, K, Morimoto, A, Ohigashi, H, Shindo, M, Nagao, M, Shimizu, T, Shirasawa, T |
K Murakami, K Irie, A Morimoto, H Ohigashi, M Shindo, M Nagao, T Shimizu, T Shirasawa |
Neurotoxicity and physicochemical properties of Aβ mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer’s disease. |
Neurotoxicity and physicochemical properties of Aβ mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer’s disease. |
Neurotoxicity and physicochemical properties of A beta mutant peptides from cerebral amyloid angiopathy - Implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease |
J. Biol. Chem. 278 (46), 46179-46187 (2003)., 278, 46, 46179-46187 |
J. Biol. Chem. 278 (46), 46179-46187 (2003)., 278, 46, 46179-46187 |
JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 46, 46179-46187 |
2003/11 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Akira Morimoto, Kazuhiro Irie, Kazuma Murakami, Hajime Ohigashi, Mayumi Shindo, Masaya Nagao, Takahiko Shimizu, Takuji Shirasawa |
Akira Morimoto, Kazuhiro Irie, Kazuma Murakami, Hajime Ohigashi, Mayumi Shindo, Masaya Nagao, Takahiko Shimizu, Takuji Shirasawa |
Akira Morimoto, Kazuhiro Irie, Kazuma Murakami, Hajime Ohigashi, Mayumi Shindo, Masaya Nagao, Takahiko Shimizu, Takuji Shirasawa |
Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23. |
Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23. |
Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23. |
Biochemical and biophysical research communications, 295, 2, 306-11 |
Biochemical and biophysical research communications, 295, 2, 306-11 |
Biochemical and biophysical research communications, 295, 2, 306-11 |
2002/07/12 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
| Murakami, K, Irie, K, Morimoto, A, Ohigashi, H, Shindo, M, Nagao, M, Shimizu, T, Shirasawa, T |
Murakami, K, Irie, K, Morimoto, A, Ohigashi, H, Shindo, M, Nagao, M, Shimizu, T, Shirasawa, T |
K Murakami, K Irie, A Morimoto, H Ohigashi, M Shindo, M Nagao, T Shimizu, T Shirasawa |
Synthesis, aggregation, neurotoxicity, and secondary structure of various Aβ1-42 mutants of familial Alzheimer’s disease at positions 21-23. |
Synthesis, aggregation, neurotoxicity, and secondary structure of various Aβ1-42 mutants of familial Alzheimer’s disease at positions 21-23. |
Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23 |
Biochem. Biophys. Res. Commun. 294 (1), 5-10 (2002)., 294, 1, 5-10 |
Biochem. Biophys. Res. Commun. 294 (1), 5-10 (2002)., 294, 1, 5-10 |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 294, 1, 5-10 |
2002/05 |
有 |
英語 |
研究論文(学術雑誌) |
公開 |
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