鈴木 雄太

最終更新日時: 2019/06/19 02:20:05

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氏名(漢字/フリガナ/アルファベット表記)
鈴木 雄太/スズキ ユウタ/Suzuki, Yuta
所属部署・職名(部局/所属/講座等/職名)
白眉センター/ /特定助教
全学電子メールアドレス
suzuki.yuta.2m @ kyoto-u.ac.jp
所属学会(国内)
学会名(日本語) 学会名(英語)
日本化学学会 The Chemical Society of Japan
日本蛋白質科学会 Protein Science Society of Japan
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士(Chemistry) M.S. (Chemistry) ミシガン大学 The University of Michigan, Ann Arbor
博士(Chemistry) Ph.D. (Chemistry) ミシガン大学 The University of Michigan, Ann Arbor
出身大学院・研究科等
大学名(日本語) 大学名(英語) 研究科名(日本語) 研究科名(英語) 専攻名(日本語) 専攻名(英語) 修了区分
ミシガン大学(米国) 化学学部ケミカルバイオロジー専攻 修了
プロフィール
(日本語)
 化学者が「デザイナー」となって思いのままに、タンパク質の機能や構造をデザインしコントロールすることが可能となれば、「必要な時、必要な機能を自発的に発動するバイオナノロボット」が、医薬・バイオテクノロジー分野で活躍する時代もそう遠くないのかもしれません。しかしながら、現行のタンパク質デザインでは、複雑性・多様性を有するタンパク質を人工的に制御する緻密かつ煩雑な技術を必要とするにも関わらず、タンパク質集合体の構造を構築するに留まっています。そこで、私が目標とするのは、タンパク質の特徴を無理矢理制御するのではなく、個々のタンパク質の本来持つ利点を最大限利用する新しい「タンパク質デザイン工学」を確立し、将来的に「バイオナノロボット」の創成を目指した研究を推進していきます。
(英語)
The ability of chemists to act as "designers" to modify protein structure and functions using a combination of rationale design and directed evolution has the potential to usher in the new era allowing the development of “smart bionanorobots programmed to perform multiple tasks for biotechnology applications”. Such "protein nanorobots" could play active roles in the field of medicine and biotechnology, and development of this technology may not be far away. However, existing protein designs require advanced techniques in order to control the diversity and complexity of protein structures. Therefore, the probability of such success is still low, and many trials-and-errors are required. So far, only primitive construction of protein assembly has been achieved. For this reason, I propose to conduct research to establish “new protein design and engineering methodology” that maximizes the actual and natural characteristics of protein targets toward creating “smart bionanorobots”, rather than forcefully controlling such potentials and characteristics.
researchmap URL
https://researchmap.jp/7000025212
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Robert Alberstein, Yuta Suzuki, Francesco Paesani, and F. Akif Tezcan Robert Alberstein, Yuta Suzuki, Francesco Paesani, and F. Akif Tezcan Robert Alberstein, Yuta Suzuki, Francesco Paesani, and F. Akif Tezcan Engineering the Entropy - Driven Energy Landscape of a Dynamic, Nanoporous Protein Assembly Engineering the Entropy - Driven Energy Landscape of a Dynamic, Nanoporous Protein Assembly Engineering the Entropy - Driven Energy Landscape of a Dynamic, Nanoporous Protein Assembly Nature Chemistry, 10, 732-739 Nature Chemistry, 10, 732-739 Nature Chemistry, 10, 732-739 2018/04 英語 研究論文(学術雑誌) 公開
Yuta Suzuki, Giovanni Cardone, David Restrepo, Pablo D. Zavattieri, Timothy S. Baker, and F. Akif Tezcan Yuta Suzuki, Giovanni Cardone, David Restrepo, Pablo D. Zavattieri, Timothy S. Baker, and F. Akif Tezcan Yuta Suzuki, Giovanni Cardone, David Restrepo, Pablo D. Zavattieri, Timothy S. Baker, and F. Akif Tezcan Self-Assembly of Coherently Dynamic, Auxetic Two-Dimensional Protein Crystals Self-Assembly of Coherently Dynamic, Auxetic Two-Dimensional Protein Crystals Self-Assembly of Coherently Dynamic, Auxetic Two-Dimensional Protein Crystals Nature, 533, 369-373 Nature, 533, 369-373 Nature, 533, 369-373 2016/05 英語 研究論文(学術雑誌) 公開
Samuel A. Kotler, Jeffrey R. Brender, Subramanian Vivekanandan, Yuta Suzuki, Kazutoshi Yamamoto, Martine Monette, Janarthanan Krishnamoorthy, Patrick Walsh, Meagan Cauble, Mark M. Banaszak Holl, E. Neil. G. Marsh, and Ayyalusamy Ramamoorthy Samuel A. Kotler, Jeffrey R. Brender, Subramanian Vivekanandan, Yuta Suzuki, Kazutoshi Yamamoto, Martine Monette, Janarthanan Krishnamoorthy, Patrick Walsh, Meagan Cauble, Mark M. Banaszak Holl, E. Neil. G. Marsh, and Ayyalusamy Ramamoorthy Samuel A. Kotler, Jeffrey R. Brender, Subramanian Vivekanandan, Yuta Suzuki, Kazutoshi Yamamoto, Martine Monette, Janarthanan Krishnamoorthy, Patrick Walsh, Meagan Cauble, Mark M. Banaszak Holl, E. Neil. G. Marsh, and Ayyalusamy Ramamoorthy High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification Scientific Reports, 5, 11811 Scientific Reports, 5, 11811 Scientific Reports, 5, 11811 2015/07 英語 研究論文(学術雑誌) 公開
Hanumantharao Paritala, Yuta Suzuki, and Kate S. Carroll Hanumantharao Paritala, Yuta Suzuki, and Kate S. Carroll Hanumantharao Paritala, Yuta Suzuki, and Kate S. Carroll Design, Synthesis and Evaluation of Fe-S Targeted Adenosine 5′-Phosphosulfate Reductase Inhibitors Design, Synthesis and Evaluation of Fe-S Targeted Adenosine 5′-Phosphosulfate Reductase Inhibitors Design, Synthesis and Evaluation of Fe-S Targeted Adenosine 5′-Phosphosulfate Reductase Inhibitors Nucleosides, Nucleotides and Nucleic Acids, 34, 199-220 Nucleosides, Nucleotides and Nucleic Acids, 34, 199-220 Nucleosides, Nucleotides and Nucleic Acids, 34, 199-220 2015/03 英語 研究論文(学術雑誌) 公開
E. Neil G. Marsh and Yuta Suzuki E. Neil G. Marsh and Yuta Suzuki E. Neil G. Marsh and Yuta Suzuki Using 19F NMR to Probe Biological Interactions of Proteins and Peptides Using 19F NMR to Probe Biological Interactions of Proteins and Peptides Using 19F NMR to Probe Biological Interactions of Proteins and Peptides ACS Chemical Biology, 9, 1242-1250 ACS Chemical Biology, 9, 1242-1250 ACS Chemical Biology, 9, 1242-1250 2014/04 英語 研究論文(学術雑誌) 公開
Hanumantharao Paritala, Yuta Suzuki, and Kate S. Carroll Hanumantharao Paritala, Yuta Suzuki, and Kate S. Carroll Hanumantharao Paritala, Yuta Suzuki, and Kate S. Carroll Efficient microwave-assisted solid phase coupling of nucleosides, small library generation, and mild conditions for release of nucleoside derivatives Efficient microwave-assisted solid phase coupling of nucleosides, small library generation, and mild conditions for release of nucleoside derivatives Efficient microwave-assisted solid phase coupling of nucleosides, small library generation, and mild conditions for release of nucleoside derivatives Tetrahedron Letter, 54, 14, 1869-1872 Tetrahedron Letter, 54, 14, 1869-1872 Tetrahedron Letter, 54, 14, 1869-1872 2013/04 英語 研究論文(学術雑誌) 公開
Yuta Suzuki, Jeffrey R. Brender, Molly T. Soper, Janarthanan Krishnamoorthy, Yunlong Zhou, Brandon T. Ruotolo, Nicholas A. Kotov, Ayyalusamy Ramamoorthy, and E. Neil G. Marsh Yuta Suzuki, Jeffrey R. Brender, Molly T. Soper, Janarthanan Krishnamoorthy, Yunlong Zhou, Brandon T. Ruotolo, Nicholas A. Kotov, Ayyalusamy Ramamoorthy, and E. Neil G. Marsh Yuta Suzuki, Jeffrey R. Brender, Molly T. Soper, Janarthanan Krishnamoorthy, Yunlong Zhou, Brandon T. Ruotolo, Nicholas A. Kotov, Ayyalusamy Ramamoorthy, and E. Neil G. Marsh Resolution of Oligomeric Species during the Aggregation of Aβ1-40 Using 19F NMR Resolution of Oligomeric Species during the Aggregation of Aβ1-40 Using 19F NMR Resolution of Oligomeric Species during the Aggregation of Aβ1-40 Using 19F NMR Biochemistry, 52, 11, 1903-1912 Biochemistry, 52, 11, 1903-1912 Biochemistry, 52, 11, 1903-1912 2013/03 英語 研究論文(学術雑誌) 公開
Yuta Suzuki Yuta Suzuki Yuta Suzuki Fluorine NMR Studies on the Dynamics and Structure of Biologically Active Peptides. Fluorine NMR Studies on the Dynamics and Structure of Biologically Active Peptides. Fluorine NMR Studies on the Dynamics and Structure of Biologically Active Peptides. University of Michigan, Ann Arbor University of Michigan, Ann Arbor University of Michigan, Ann Arbor 2013 英語 学位論文(博士) 公開
Thangaiah Subramanian, June E. Pais, Suxia Liu, Jerry M. Troutman, Yuta Suzuki, Karunai L. Subramanian, Carol A. Fierke, Douglas A. Andres, and H. Peter Spielmann Thangaiah Subramanian, June E. Pais, Suxia Liu, Jerry M. Troutman, Yuta Suzuki, Karunai L. Subramanian, Carol A. Fierke, Douglas A. Andres, and H. Peter Spielmann Thangaiah Subramanian, June E. Pais, Suxia Liu, Jerry M. Troutman, Yuta Suzuki, Karunai L. Subramanian, Carol A. Fierke, Douglas A. Andres, and H. Peter Spielmann Farnesyl Diphosphate Analogues with Aryl Moieties are Efficient Alternate Substrates for Protein Farnesyltransferase Farnesyl Diphosphate Analogues with Aryl Moieties are Efficient Alternate Substrates for Protein Farnesyltransferase Farnesyl Diphosphate Analogues with Aryl Moieties are Efficient Alternate Substrates for Protein Farnesyltransferase Biochemistry, 51, 41, 8307-8319 Biochemistry, 51, 41, 8307-8319 Biochemistry, 51, 41, 8307-8319 2012/10 英語 研究論文(学術雑誌) 公開
Yuta Suzuki, Jeffrey R. Brender, Kevin Hartman, Ayyalusamy Ramamoorthy, and E. Neil G. Marsh Yuta Suzuki, Jeffrey R. Brender, Kevin Hartman, Ayyalusamy Ramamoorthy, and E. Neil G. Marsh Yuta Suzuki, Jeffrey R. Brender, Kevin Hartman, Ayyalusamy Ramamoorthy, and E. Neil G. Marsh Alternative Pathways of Human Islet Amyloid Polypeptide Aggregation Distinguished by 19F NMR Detected Kinetics of Monomer Consumption. Alternative Pathways of Human Islet Amyloid Polypeptide Aggregation Distinguished by 19F NMR Detected Kinetics of Monomer Consumption. Alternative Pathways of Human Islet Amyloid Polypeptide Aggregation Distinguished by 19F NMR Detected Kinetics of Monomer Consumption. Biochemistry, 51, 41, 8154-8162 Biochemistry, 51, 41, 8154-8162 Biochemistry, 51, 41, 8154-8162 2012/09 英語 研究論文(学術雑誌) 公開
Richard P. Cheng, Yi-Jen Weng, Wei-Ren Wang, Marc J. Koyack, Yuta Suzuki, Cheng-Hsun Wu, Po-An Yang, Hao-Chun Hsu, Hsiou-Ting Kuo, Prashant Girinath, Chun-Jen Fang Richard P. Cheng, Yi-Jen Weng, Wei-Ren Wang, Marc J. Koyack, Yuta Suzuki, Cheng-Hsun Wu, Po-An Yang, Hao-Chun Hsu, Hsiou-Ting Kuo, Prashant Girinath, Chun-Jen Fang Richard P. Cheng, Yi-Jen Weng, Wei-Ren Wang, Marc J. Koyack, Yuta Suzuki, Cheng-Hsun Wu, Po-An Yang, Hao-Chun Hsu, Hsiou-Ting Kuo, Prashant Girinath, Chun-Jen Fang Helix Formation and Capping Energetics of Arginine Analogs with Varying Side Chain Length Helix Formation and Capping Energetics of Arginine Analogs with Varying Side Chain Length Helix Formation and Capping Energetics of Arginine Analogs with Varying Side Chain Length Amino Acids, 43, 1, 195-206 Amino Acids, 43, 1, 195-206 Amino Acids, 43, 1, 195-206 2011/09 英語 研究論文(学術雑誌) 公開
Yuta Suzuki, Benjamin C. Buer, Hashim M. Al-Hashimi, and E. Neil G. Marsh Yuta Suzuki, Benjamin C. Buer, Hashim M. Al-Hashimi, and E. Neil G. Marsh Yuta Suzuki, Benjamin C. Buer, Hashim M. Al-Hashimi, and E. Neil G. Marsh Using Fluorine NMR to Probe Changes in Structure and Dynamics of Membrane-Active Peptides Interacting with the Lipid Bilayer Using Fluorine NMR to Probe Changes in Structure and Dynamics of Membrane-Active Peptides Interacting with the Lipid Bilayer Using Fluorine NMR to Probe Changes in Structure and Dynamics of Membrane-Active Peptides Interacting with the Lipid Bilayer Biochemistry, 50, 27, 5979-5987 Biochemistry, 50, 27, 5979-5987 Biochemistry, 50, 27, 5979-5987 2011/07 英語 研究論文(学術雑誌) 公開
Richard P. Cheng, Prashant Girinath, Yuta Suzuki, Hsiou-Ting Kuo, Hao-Chun Hsu, Wei-Ren Wang, Po-An Yang, Donald Gullickson, Cheng-Hsun Wu, Marc J. Koyack, Hsien-Po Chiu, Yi-Jen Weng, Pier Hart, Bashkim Kokona, Robert Fairman, Tzu-En Lin, and Olivia Barrett Richard P. Cheng, Prashant Girinath, Yuta Suzuki, Hsiou-Ting Kuo, Hao-Chun Hsu, Wei-Ren Wang, Po-An Yang, Donald Gullickson, Cheng-Hsun Wu, Marc J. Koyack, Hsien-Po Chiu, Yi-Jen Weng, Pier Hart, Bashkim Kokona, Robert Fairman, Tzu-En Lin, and Olivia Barrett Richard P. Cheng, Prashant Girinath, Yuta Suzuki, Hsiou-Ting Kuo, Hao-Chun Hsu, Wei-Ren Wang, Po-An Yang, Donald Gullickson, Cheng-Hsun Wu, Marc J. Koyack, Hsien-Po Chiu, Yi-Jen Weng, Pier Hart, Bashkim Kokona, Robert Fairman, Tzu-En Lin, and Olivia Barrett Positional Effects on Helical Ala-Based Peptides Positional Effects on Helical Ala-Based Peptides Positional Effects on Helical Ala-Based Peptides Biochemistry, 49, 43, 9372-9384 Biochemistry, 49, 43, 9372-9384 Biochemistry, 49, 43, 9372-9384 2010/10 英語 研究論文(学術雑誌) 公開
Hsien-Po Chiu, Yuta Suzuki, Donald Gullickson, Raheel Ahmad, Bashkim Kokona, Robert Fairman, and Richard P. Cheng Hsien-Po Chiu, Yuta Suzuki, Donald Gullickson, Raheel Ahmad, Bashkim Kokona, Robert Fairman, and Richard P. Cheng Hsien-Po Chiu, Yuta Suzuki, Donald Gullickson, Raheel Ahmad, Bashkim Kokona, Robert Fairman, and Richard P. Cheng Helix Propensity of Highly Fluorinated Amino Acids Helix Propensity of Highly Fluorinated Amino Acids Helix Propensity of Highly Fluorinated Amino Acids Journal of the American Chemical Society, 128, 49, 15556-15557 Journal of the American Chemical Society, 128, 49, 15556-15557 Journal of the American Chemical Society, 128, 49, 15556-15557 2006/11 英語 研究論文(学術雑誌) 公開

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著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
鈴木 雄太 鈴木 雄太 SUNY/ミシガン/UCSD大学留学体験記 ~From Art To Chemistry~” SUNY/ミシガン/UCSD大学留学体験記 ~From Art To Chemistry~” 生命化学研究レター, 53, 26-33 生命化学研究レター, 53, 26-33 , 53, 26-33 2017/02 日本語 速報、短報、研究ノート等(学術雑誌) 公開
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