吉原 亨

最終更新日時: 2019/06/28 11:46:47

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氏名(漢字/フリガナ/アルファベット表記)
吉原 亨/ヨシハラ トオル/Yoshihara, Toru
所属部署・職名(部局/所属/講座等/職名)
医学研究科/医学研究科附属動物実験施設/ /特定助教
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士(心理学) 筑波大学
博士(行動科学) 筑波大学
researchmap URL
https://researchmap.jp/7000011388
研究テーマ
(日本語)
遺伝子改変マウスを対象とした行動神経科学的解析
(英語)
Behavioral neuroscience using genetically engineering mice
研究概要
(日本語)
脳精神機能における遺伝子の役割を,特に遺伝子改変マウスを用いた解析により検討している.
(英語)
The role of genes in brain/mental function is examined using genetically engineering mice.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
マウス,行動解析,脳機能,精神疾患,神経科学  mouse, behavioral analysis, brain function, mental disorder, neuroscience
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Matsuzaki T, Yoshihara T, Ohtsuka T, Kageyama R Matsuzaki T, Yoshihara T, Ohtsuka T, Kageyama R Matsuzaki T, Yoshihara T, Ohtsuka T, Kageyama R Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors. Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors. Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors. Scientific reports, 9, 1, 8251 Scientific reports, 9, 1, 8251 Scientific reports, 9, 1, 8251 2019/06 公開
Yoshihara T, Satake H, Nishie T, Okino N, Hatta T, Otani H, Naruse C, Suzuki H, Sugihara K, Kamimura E, Tokuda N, Furukawa K, Fururkawa K, Ito M, Asano M Yoshihara T, Satake H, Nishie T, Okino N, Hatta T, Otani H, Naruse C, Suzuki H, Sugihara K, Kamimura E, Tokuda N, Furukawa K, Fururkawa K, Ito M, Asano M Yoshihara T, Satake H, Nishie T, Okino N, Hatta T, Otani H, Naruse C, Suzuki H, Sugihara K, Kamimura E, Tokuda N, Furukawa K, Fururkawa K, Ito M, Asano M Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice. Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice. Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice. PLoS genetics, 14, 8, e1007545 PLoS genetics, 14, 8, e1007545 PLoS genetics, 14, 8, e1007545 2018/08 公開
Higashida H, Liang M, Yoshihara T, Akther S, Fakhrul A, Stanislav C, Nam TS, Kim UH, Kasai S, Nishimura T, Al Mahmuda N, Yokoyama S, Ishihara K, Gerasimenko M, Salmina A, Zhong J, Tsuji T, Tsuji C, Lopatina O Higashida H, Liang M, Yoshihara T, Akther S, Fakhrul A, Stanislav C, Nam TS, Kim UH, Kasai S, Nishimura T, Al Mahmuda N, Yokoyama S, Ishihara K, Gerasimenko M, Salmina A, Zhong J, Tsuji T, Tsuji C, Lopatina O Higashida H, Liang M, Yoshihara T, Akther S, Fakhrul A, Stanislav C, Nam TS, Kim UH, Kasai S, Nishimura T, Al Mahmuda N, Yokoyama S, Ishihara K, Gerasimenko M, Salmina A, Zhong J, Tsuji T, Tsuji C, Lopatina O An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator. An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator. An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator. BMC neuroscience, 18, 1, 35 BMC neuroscience, 18, 1, 35 BMC neuroscience, 18, 1, 35 2017/03 公開
Kasai S, Yoshihara T, Lopatina O, Ishihara K, Higashida H Kasai S, Yoshihara T, Lopatina O, Ishihara K, Higashida H Kasai S, Yoshihara T, Lopatina O, Ishihara K, Higashida H Selegiline Ameliorates Depression-Like Behavior in Mice Lacking the <i>CD157/BST1</i> Gene, a Risk Factor for Parkinson's Disease. Selegiline Ameliorates Depression-Like Behavior in Mice Lacking the <i>CD157/BST1</i> Gene, a Risk Factor for Parkinson's Disease. Selegiline Ameliorates Depression-Like Behavior in Mice Lacking the <i>CD157/BST1</i> Gene, a Risk Factor for Parkinson's Disease. Frontiers in behavioral neuroscience, 11, 75 Frontiers in behavioral neuroscience, 11, 75 Frontiers in behavioral neuroscience, 11, 75 2017 公開
Georgiev D, Yoshihara T, Kawabata R, Matsubara T, Tsubomoto M, Minabe Y, Lewis DA, Hashimoto T Georgiev D, Yoshihara T, Kawabata R, Matsubara T, Tsubomoto M, Minabe Y, Lewis DA, Hashimoto T Georgiev D, Yoshihara T, Kawabata R, Matsubara T, Tsubomoto M, Minabe Y, Lewis DA, Hashimoto T Cortical Gene Expression After a Conditional Knockout of 67 kDa Glutamic Acid Decarboxylase in Parvalbumin Neurons. Cortical Gene Expression After a Conditional Knockout of 67 kDa Glutamic Acid Decarboxylase in Parvalbumin Neurons. Cortical Gene Expression After a Conditional Knockout of 67 kDa Glutamic Acid Decarboxylase in Parvalbumin Neurons. Schizophrenia bulletin, 42, 4, 992-1002 Schizophrenia bulletin, 42, 4, 992-1002 Schizophrenia bulletin, 42, 4, 992-1002 2016/07 公開
Sato T, Ishikawa M, Yoshihara T, Nakazato R, Higashida H, Asano M, Yoshioka K Sato T, Ishikawa M, Yoshihara T, Nakazato R, Higashida H, Asano M, Yoshioka K Sato T, Ishikawa M, Yoshihara T, Nakazato R, Higashida H, Asano M, Yoshioka K Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice. Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice. Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice. FEBS letters, 589, 19 Pt B, 2805-2811 FEBS letters, 589, 19 Pt B, 2805-2811 FEBS letters, 589, 19 Pt B, 2805-2811 2015/09 公開
Yaji S, Manya H, Nakagawa N, Takematsu H, Endo T, Kannagi R, Yoshihara T, Asano M, Oka S Yaji S, Manya H, Nakagawa N, Takematsu H, Endo T, Kannagi R, Yoshihara T, Asano M, Oka S Yaji S, Manya H, Nakagawa N, Takematsu H, Endo T, Kannagi R, Yoshihara T, Asano M, Oka S Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTPβ. Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTPβ. Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTPβ. Glycobiology, 25, 4, 376-385 Glycobiology, 25, 4, 376-385 Glycobiology, 25, 4, 376-385 2015/04 公開
Mizuno A, Cherepanov SM, Kikuchi Y, Fakhrul AA, Akther S, Deguchi K, Yoshihara T, Ishihara K, Shuto S, Higashida H Mizuno A, Cherepanov SM, Kikuchi Y, Fakhrul AA, Akther S, Deguchi K, Yoshihara T, Ishihara K, Shuto S, Higashida H Mizuno A, Cherepanov SM, Kikuchi Y, Fakhrul AA, Akther S, Deguchi K, Yoshihara T, Ishihara K, Shuto S, Higashida H Lipo-oxytocin-1, a Novel Oxytocin Analog Conjugated with Two Palmitoyl Groups, Has Long-Lasting Effects on Anxiety-Related Behavior and Social Avoidance in CD157 Knockout Mice. Lipo-oxytocin-1, a Novel Oxytocin Analog Conjugated with Two Palmitoyl Groups, Has Long-Lasting Effects on Anxiety-Related Behavior and Social Avoidance in CD157 Knockout Mice. Lipo-oxytocin-1, a Novel Oxytocin Analog Conjugated with Two Palmitoyl Groups, Has Long-Lasting Effects on Anxiety-Related Behavior and Social Avoidance in CD157 Knockout Mice. Brain sciences, 5, 1, 3-13 Brain sciences, 5, 1, 3-13 Brain sciences, 5, 1, 3-13 2015/01 公開
Lopatina O, Yoshihara T, Nishimura T, Zhong J, Akther S, Fakhrul AA, Liang M, Higashida C, Sumi K, Furuhara K, Inahata Y, Huang JJ, Koizumi K, Yokoyama S, Tsuji T, Petugina Y, Sumarokov A, Salmina AB, Hashida K, Kitao Y, Hori O, Asano M, Kitamura Y, Kozaka T, Shiba K, Zhong F, Xie MJ, Sato M, Ishihara K, Higashida H Lopatina O, Yoshihara T, Nishimura T, Zhong J, Akther S, Fakhrul AA, Liang M, Higashida C, Sumi K, Furuhara K, Inahata Y, Huang JJ, Koizumi K, Yokoyama S, Tsuji T, Petugina Y, Sumarokov A, Salmina AB, Hashida K, Kitao Y, Hori O, Asano M, Kitamura Y, Kozaka T, Shiba K, Zhong F, Xie MJ, Sato M, Ishihara K, Higashida H Lopatina O, Yoshihara T, Nishimura T, Zhong J, Akther S, Fakhrul AA, Liang M, Higashida C, Sumi K, Furuhara K, Inahata Y, Huang JJ, Koizumi K, Yokoyama S, Tsuji T, Petugina Y, Sumarokov A, Salmina AB, Hashida K, Kitao Y, Hori O, Asano M, Kitamura Y, Kozaka T, Shiba K, Zhong F, Xie MJ, Sato M, Ishihara K, Higashida H Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease. Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease. Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease. Frontiers in behavioral neuroscience, 8, 133 Frontiers in behavioral neuroscience, 8, 133 Frontiers in behavioral neuroscience, 8, 133 2014 公開
Liu HX, Lopatina O, Higashida C, Fujimoto H, Akther S, Inzhutova A, Liang M, Zhong J, Tsuji T, Yoshihara T, Sumi K, Ishiyama M, Ma WJ, Ozaki M, Yagitani S, Yokoyama S, Mukaida N, Sakurai T, Hori O, Yoshioka K, Hirao A, Kato Y, Ishihara K, Kato I, Okamoto H, Cherepanov SM, Salmina AB, Hirai H, Asano M, Brown DA, Nagano I, Higashida H Liu HX, Lopatina O, Higashida C, Fujimoto H, Akther S, Inzhutova A, Liang M, Zhong J, Tsuji T, Yoshihara T, Sumi K, Ishiyama M, Ma WJ, Ozaki M, Yagitani S, Yokoyama S, Mukaida N, Sakurai T, Hori O, Yoshioka K, Hirao A, Kato Y, Ishihara K, Kato I, Okamoto H, Cherepanov SM, Salmina AB, Hirai H, Asano M, Brown DA, Nagano I, Higashida H Liu HX, Lopatina O, Higashida C, Fujimoto H, Akther S, Inzhutova A, Liang M, Zhong J, Tsuji T, Yoshihara T, Sumi K, Ishiyama M, Ma WJ, Ozaki M, Yagitani S, Yokoyama S, Mukaida N, Sakurai T, Hori O, Yoshioka K, Hirao A, Kato Y, Ishihara K, Kato I, Okamoto H, Cherepanov SM, Salmina AB, Hirai H, Asano M, Brown DA, Nagano I, Higashida H Displays of paternal mouse pup retrieval following communicative interaction with maternal mates. Displays of paternal mouse pup retrieval following communicative interaction with maternal mates. Displays of paternal mouse pup retrieval following communicative interaction with maternal mates. Nature communications, 4, 1346 Nature communications, 4, 1346 Nature communications, 4, 1346 2013 公開
Ito M, Sugihara K, Asaka T, Toyama T, Yoshihara T, Furuichi K, Wada T, Asano M Ito M, Sugihara K, Asaka T, Toyama T, Yoshihara T, Furuichi K, Wada T, Asano M Ito M, Sugihara K, Asaka T, Toyama T, Yoshihara T, Furuichi K, Wada T, Asano M Glycoprotein hyposialylation gives rise to a nephrotic-like syndrome that is prevented by sialic acid administration in GNE V572L point-mutant mice. Glycoprotein hyposialylation gives rise to a nephrotic-like syndrome that is prevented by sialic acid administration in GNE V572L point-mutant mice. Glycoprotein hyposialylation gives rise to a nephrotic-like syndrome that is prevented by sialic acid administration in GNE V572L point-mutant mice. PloS one, 7, 1, e29873 PloS one, 7, 1, e29873 PloS one, 7, 1, e29873 2012 公開
Kouno T, Kizuka Y, Nakagawa N, Yoshihara T, Asano M, Oka S Kouno T, Kizuka Y, Nakagawa N, Yoshihara T, Asano M, Oka S Kouno T, Kizuka Y, Nakagawa N, Yoshihara T, Asano M, Oka S Specific enzyme complex of beta-1,4-galactosyltransferase-II and glucuronyltransferase-P facilitates biosynthesis of N-linked human natural killer-1 (HNK-1) carbohydrate. Specific enzyme complex of beta-1,4-galactosyltransferase-II and glucuronyltransferase-P facilitates biosynthesis of N-linked human natural killer-1 (HNK-1) carbohydrate. Specific enzyme complex of beta-1,4-galactosyltransferase-II and glucuronyltransferase-P facilitates biosynthesis of N-linked human natural killer-1 (HNK-1) carbohydrate. The Journal of biological chemistry, 286, 36, 31337-31346 The Journal of biological chemistry, 286, 36, 31337-31346 The Journal of biological chemistry, 286, 36, 31337-31346 2011/09 公開
Yoshihara T, Sugihara K, Kizuka Y, Oka S, Asano M Yoshihara T, Sugihara K, Kizuka Y, Oka S, Asano M Yoshihara T, Sugihara K, Kizuka Y, Oka S, Asano M Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in beta4-galactosyltransferase-II-deficient mice. Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in beta4-galactosyltransferase-II-deficient mice. Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in beta4-galactosyltransferase-II-deficient mice. The Journal of biological chemistry, 284, 18, 12550-12561 The Journal of biological chemistry, 284, 18, 12550-12561 The Journal of biological chemistry, 284, 18, 12550-12561 2009/05 公開
Hayashi K, Yoshihara T, Ichitani Y Hayashi K, Yoshihara T, Ichitani Y Hayashi K, Yoshihara T, Ichitani Y Involvement of hippocampal metabotropic glutamate receptors in radial maze performance. Involvement of hippocampal metabotropic glutamate receptors in radial maze performance. Involvement of hippocampal metabotropic glutamate receptors in radial maze performance. Neuroreport, 18, 7, 719-723 Neuroreport, 18, 7, 719-723 Neuroreport, 18, 7, 719-723 2007/05 公開
Jin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M, Seike T, Fujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi Y, Tanaka S, Hashii M, Yoshihara T, Higashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M, Higashida H Jin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M, Seike T, Fujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi Y, Tanaka S, Hashii M, Yoshihara T, Higashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M, Higashida H Jin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M, Seike T, Fujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi Y, Tanaka S, Hashii M, Yoshihara T, Higashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M, Higashida H CD38 is critical for social behaviour by regulating oxytocin secretion. CD38 is critical for social behaviour by regulating oxytocin secretion. CD38 is critical for social behaviour by regulating oxytocin secretion. Nature, 446, 7131, 41-45 Nature, 446, 7131, 41-45 Nature, 446, 7131, 41-45 2007/03 公開

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タイトル言語:
外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
基盤研究(C) 代表 ヘテロクロマチン因子HP1欠損による精神疾患モデルマウスの確立と原因の解明 (平成28年度分) 2016/04/01〜2017/03/31
基盤研究(C) 代表 ヘテロクロマチン因子HP1欠損による精神疾患モデルマウスの確立と原因の解明 (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(C) 代表 ヘテロクロマチン因子HP1欠損による精神疾患モデルマウスの確立と原因の解明 (平成30年度分) 2018/04/01〜2019/03/31
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
実験動物学 Laboratory Animal Science 前期前半 医学部(人間健康科学科) 2019/04〜2020/03