金 永輝

最終更新日時: 2018/06/27 11:23:03

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氏名(漢字/フリガナ/アルファベット表記)
金 永輝/キン エイキ/Jin, Yonghui
所属部署・職名(部局/所属/講座等/職名)
ウイルス・再生医科学研究所/再生組織構築研究部門/助教
プロフィール
(日本語)
臨床応用を目指した基礎研究を行っている。基礎医学研究の成果を社会に還元することで、患者が従来の治療法より効果がよく、副作用が低い新規治療法を受けることができる。
(英語)
I am conducting the basic research aimed at clinical application. By returning the results of fundamental medical research to society, patients can receive a novel therapy which is more effective and has lower side effects than conventional treatments.
researchmap URL
https://researchmap.jp/7000010625
研究テーマ
(日本語)
難治疾患の病理学的機構を解明すると共に、新規治療法を開発する。
(英語)
Elucidating the pathological mechanism and developing new therapies of intractable diseases.
研究概要
(日本語)
患者さん由来細胞からiPS細胞を樹立した後、特定な細胞に分化させ、難治疾患を体外で再現することで、病理的機構を解明する。この疾患iPS細胞を使ったモデルを用いて、新規治療法の開発に取り込んでいる。
(英語)
The established iPS cells from the patient-derived cells was differentiated into specific cell lineage. Using this type of cells, we recaptured and elucidated the pathological mechanism. We are working on the development of novel therapies with this disease model.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
幹細胞生物学
腫瘍学
整形外科学
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
金 永輝 金 永輝 Yonghui Jin Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva The Journal of Clinical Investigation, 127, 9, 3339-3352 The Journal of Clinical Investigation, 127, 9, 3339-3352 The Journal of Clinical Investigation, 127, 9, 3339-3352 2017/09 英語 研究論文(学術雑誌) 公開
Tamaki S, Fukuta M, Sekiguchi K, Jin Y, Nagata S, Hayakawa K, Hineno S, Okamoto T, Watanabe M, Woltjen K, Ikeya M, Kato T Jr, Toguchida J Tamaki S, Fukuta M, Sekiguchi K, Jin Y, Nagata S, Hayakawa K, Hineno S, Okamoto T, Watanabe M, Woltjen K, Ikeya M, Kato T Jr, Toguchida J Tamaki S, Fukuta M, Sekiguchi K, Jin Y, Nagata S, Hayakawa K, Hineno S, Okamoto T, Watanabe M, Woltjen K, Ikeya M, Kato T Jr, Toguchida J SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier. SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier. SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier. PloS one, 10, 11 PloS one, 10, 11 PloS one, 10, 11 2015 公開
Jin Y, Elalaf H, Watanabe M, Tamaki S, Hineno S, Matsunaga K, Woltjen K, Kobayashi Y, Nagata S, Ikeya M, Kato T Jr, Okamoto T, Matsuda S, Toguchida J Jin Y, Elalaf H, Watanabe M, Tamaki S, Hineno S, Matsunaga K, Woltjen K, Kobayashi Y, Nagata S, Ikeya M, Kato T Jr, Okamoto T, Matsuda S, Toguchida J Jin Y, Elalaf H, Watanabe M, Tamaki S, Hineno S, Matsunaga K, Woltjen K, Kobayashi Y, Nagata S, Ikeya M, Kato T Jr, Okamoto T, Matsuda S, Toguchida J Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes. Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes. Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes. PloS one, 10, 7 PloS one, 10, 7 PloS one, 10, 7 2015 公開
Takahashi R, Nagayama S, Furu M, Kajita Y, Jin Y, Kato T, Imoto S, Sakai Y, Toguchida J Takahashi R, Nagayama S, Furu M, Kajita Y, Jin Y, Kato T, Imoto S, Sakai Y, Toguchida J Takahashi R, Nagayama S, Furu M, Kajita Y, Jin Y, Kato T, Imoto S, Sakai Y, Toguchida J AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers. AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers. AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers. Cancer medicine, 3, 4, 759-774 Cancer medicine, 3, 4, 759-774 Cancer medicine, 3, 4, 759-774 2014/08 公開
Nasu A, Ikeya M, Yamamoto T, Watanabe A, Jin Y, Matsumoto Y, Hayakawa K, Amano N, Sato S, Osafune K, Aoyama T, Nakamura T, Kato T, Toguchida J Nasu A, Ikeya M, Yamamoto T, Watanabe A, Jin Y, Matsumoto Y, Hayakawa K, Amano N, Sato S, Osafune K, Aoyama T, Nakamura T, Kato T, Toguchida J Nasu A, Ikeya M, Yamamoto T, Watanabe A, Jin Y, Matsumoto Y, Hayakawa K, Amano N, Sato S, Osafune K, Aoyama T, Nakamura T, Kato T, Toguchida J Genetically matched human iPS cells reveal that propensity for cartilage and bone differentiation differs with clones, not cell type of origin. Genetically matched human iPS cells reveal that propensity for cartilage and bone differentiation differs with clones, not cell type of origin. Genetically matched human iPS cells reveal that propensity for cartilage and bone differentiation differs with clones, not cell type of origin. PloS one, 8, 1 PloS one, 8, 1 PloS one, 8, 1 2013 公開
Mitsui H, Aoyama T, Furu M, Ito K, Jin Y, Maruyama T, Kanaji T, Fujimura S, Sugihara H, Nishiura A, Otsuka T, Nakamura T, Toguchida J Mitsui H, Aoyama T, Furu M, Ito K, Jin Y, Maruyama T, Kanaji T, Fujimura S, Sugihara H, Nishiura A, Otsuka T, Nakamura T, Toguchida J Mitsui H, Aoyama T, Furu M, Ito K, Jin Y, Maruyama T, Kanaji T, Fujimura S, Sugihara H, Nishiura A, Otsuka T, Nakamura T, Toguchida J Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability. Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability. Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability. Arthritis research & therapy, 13, 5 Arthritis research & therapy, 13, 5 Arthritis research & therapy, 13, 5 2011 公開
Aoyama T, Okamoto T, Fukiage K, Otsuka S, Furu M, Ito K, Jin Y, Ueda M, Nagayama S, Nakayama T, Nakamura T, Toguchida J Aoyama T, Okamoto T, Fukiage K, Otsuka S, Furu M, Ito K, Jin Y, Ueda M, Nagayama S, Nakayama T, Nakamura T, Toguchida J Aoyama T, Okamoto T, Fukiage K, Otsuka S, Furu M, Ito K, Jin Y, Ueda M, Nagayama S, Nakayama T, Nakamura T, Toguchida J Histone modifiers, YY1 and p300, regulate the expression of cartilage-specific gene, chondromodulin-I, in mesenchymal stem cells. Histone modifiers, YY1 and p300, regulate the expression of cartilage-specific gene, chondromodulin-I, in mesenchymal stem cells. Histone modifiers, YY1 and p300, regulate the expression of cartilage-specific gene, chondromodulin-I, in mesenchymal stem cells. The Journal of biological chemistry, 285, 39, 29842-29850 The Journal of biological chemistry, 285, 39, 29842-29850 The Journal of biological chemistry, 285, 39, 29842-29850 2010/09 公開
Ito K, Aoyama T, Fukiage K, Otsuka S, Furu M, Jin Y, Nasu A, Ueda M, Kasai Y, Ashihara E, Kimura S, Maekawa T, Kobayashi A, Yoshida S, Niwa H, Otsuka T, Nakamura T, Toguchida J Ito K, Aoyama T, Fukiage K, Otsuka S, Furu M, Jin Y, Nasu A, Ueda M, Kasai Y, Ashihara E, Kimura S, Maekawa T, Kobayashi A, Yoshida S, Niwa H, Otsuka T, Nakamura T, Toguchida J Ito K, Aoyama T, Fukiage K, Otsuka S, Furu M, Jin Y, Nasu A, Ueda M, Kasai Y, Ashihara E, Kimura S, Maekawa T, Kobayashi A, Yoshida S, Niwa H, Otsuka T, Nakamura T, Toguchida J A novel method to isolate mesenchymal stem cells from bone marrow in a closed system using a device made by nonwoven fabric. A novel method to isolate mesenchymal stem cells from bone marrow in a closed system using a device made by nonwoven fabric. A novel method to isolate mesenchymal stem cells from bone marrow in a closed system using a device made by nonwoven fabric. Tissue engineering. Part C, Methods, 16, 1, 81-91 Tissue engineering. Part C, Methods, 16, 1, 81-91 Tissue engineering. Part C, Methods, 16, 1, 81-91 2010/02 公開
Jin Y, Shima Y, Furu M, Aoyama T, Nakamata T, Nakayama T, Nakamura T, Toguchida J Jin Y, Shima Y, Furu M, Aoyama T, Nakamata T, Nakayama T, Nakamura T, Toguchida J Jin Y, Shima Y, Furu M, Aoyama T, Nakamata T, Nakayama T, Nakamura T, Toguchida J Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients. Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients. Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients. Anticancer research, 30, 1, 245-251 Anticancer research, 30, 1, 245-251 Anticancer research, 30, 1, 245-251 2010/01 公開
Jin Y, Kato T, Furu M, Nasu A, Kajita Y, Mitsui H, Ueda M, Aoyama T, Nakayama T, Nakamura T, Toguchida J Jin Y, Kato T, Furu M, Nasu A, Kajita Y, Mitsui H, Ueda M, Aoyama T, Nakayama T, Nakamura T, Toguchida J Jin Y, Kato T, Furu M, Nasu A, Kajita Y, Mitsui H, Ueda M, Aoyama T, Nakayama T, Nakamura T, Toguchida J Mesenchymal stem cells cultured under hypoxia escape from senescence via down-regulation of p16 and extracellular signal regulated kinase. Mesenchymal stem cells cultured under hypoxia escape from senescence via down-regulation of p16 and extracellular signal regulated kinase. Mesenchymal stem cells cultured under hypoxia escape from senescence via down-regulation of p16 and extracellular signal regulated kinase. Biochemical and biophysical research communications, 391, 3, 1471-1476 Biochemical and biophysical research communications, 391, 3, 1471-1476 Biochemical and biophysical research communications, 391, 3, 1471-1476 2010/01 公開
Fukiage K, Aoyama T, Shibata KR, Otsuka S, Furu M, Kohno Y, Ito K, Jin Y, Fujita S, Fujibayashi S, Neo M, Nakayama T, Nakamura T, Toguchida J Fukiage K, Aoyama T, Shibata KR, Otsuka S, Furu M, Kohno Y, Ito K, Jin Y, Fujita S, Fujibayashi S, Neo M, Nakayama T, Nakamura T, Toguchida J Fukiage K, Aoyama T, Shibata KR, Otsuka S, Furu M, Kohno Y, Ito K, Jin Y, Fujita S, Fujibayashi S, Neo M, Nakayama T, Nakamura T, Toguchida J Expression of vascular cell adhesion molecule-1 indicates the differentiation potential of human bone marrow stromal cells. Expression of vascular cell adhesion molecule-1 indicates the differentiation potential of human bone marrow stromal cells. Expression of vascular cell adhesion molecule-1 indicates the differentiation potential of human bone marrow stromal cells. Biochemical and biophysical research communications, 365, 3, 406-412 Biochemical and biophysical research communications, 365, 3, 406-412 Biochemical and biophysical research communications, 365, 3, 406-412 2008/01 公開
Aoyama T, Okamoto T, Kohno Y, Fukiage K, Otsuka S, Furu M, Ito K, Jin Y, Nagayama S, Nakayama T, Nakamura T, Toguchida J Aoyama T, Okamoto T, Kohno Y, Fukiage K, Otsuka S, Furu M, Ito K, Jin Y, Nagayama S, Nakayama T, Nakamura T, Toguchida J Aoyama T, Okamoto T, Kohno Y, Fukiage K, Otsuka S, Furu M, Ito K, Jin Y, Nagayama S, Nakayama T, Nakamura T, Toguchida J Cell-specific epigenetic regulation of ChM-I gene expression: crosstalk between DNA methylation and histone acetylation. Cell-specific epigenetic regulation of ChM-I gene expression: crosstalk between DNA methylation and histone acetylation. Cell-specific epigenetic regulation of ChM-I gene expression: crosstalk between DNA methylation and histone acetylation. Biochemical and biophysical research communications, 365, 1, 124-130 Biochemical and biophysical research communications, 365, 1, 124-130 Biochemical and biophysical research communications, 365, 1, 124-130 2008/01 公開

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