中馬 新一郎

最終更新日時: 2019/06/28 15:38:24

印刷する

氏名(漢字/フリガナ/アルファベット表記)
中馬 新一郎/チユウマ シンイチロウ/Chuma, Shinichiro
所属部署・職名(部局/所属/講座等/職名)
ウイルス・再生医科学研究所/再生組織構築研究部門/准教授
協力講座
部局 所属 講座等 職名
医学研究科 医学専攻 発生分化研究 准教授
医学研究科 医科学専攻 発生分化研究 准教授
学内兼務
部局 所属 講座等 職名
物質-細胞統合システム拠点 連携准教授
連絡先住所
種別 住所(日本語) 住所(英語)
職場 〒606-8507 京都府京都市左京区聖護院川原町 53
連絡先電話番号
種別 番号
職場 075-751-3821
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
博士(理学) 総合研究大学院大学
出身大学院・研究科等
大学名(日本語) 大学名(英語) 研究科名(日本語) 研究科名(英語) 専攻名(日本語) 専攻名(英語) 修了区分
総合研究大学院大学 生命科学研究科博士後期課程遺伝学専攻 修了
researchmap URL
https://researchmap.jp/read0094704
研究テーマ
(日本語)
生殖系列サイクルの遺伝的安定性の発生制御メカニズム
研究概要
(日本語)
生物の遺伝情報は常に損傷と修復を繰り返して変化する。多細胞生物では受精を起点に個々の細胞の遺伝情報は変異を蓄積して癌や老化等の原因になるものと考えられる。しかし各細胞系譜の遺伝的安定性は均一ではなく、幹細胞システムは分化細胞と比べて遺伝情報をより安定に維持する事で生体恒常性を保ち、また生殖系列サイクルは特に遺伝情報の安定性が高いものと考えられる。しかし、遺伝的安定性がどの様に発生プログラムと連携して機能調節を受けるのか、また何故生殖系列サイクルの遺伝的安定性は特に高いのか、その制御基盤の理解は殆ど進んでいない。我々は哺乳類の初期発生過程と生殖系列サイクルの遺伝的安定性の発生制御メカニズムの解明とその理解に基づいた再構成を目的として、マウス多能性幹細胞と生殖幹細胞の in vitro 増殖分化モデルおよび in vivo 初期胚や生殖細胞を用いた実証研究により、(1)初期発生と生殖系列サイクルの遺伝的安定性の発生制御の全体像、(2)遺伝的安定性の制御遺伝子群の発現調節機構、(3)遺伝的安定性の人為制御が細胞・個体に与える影響、の解明を目指している。遺伝的安定性の発生制御は生物学上の重要課題であると共にその操作技術は幹細胞リソースの応用等にも広く重要である。
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
幹細胞 Stem cell
生殖細胞 Germ cell
ゲノム Genome
エピゲノム Epigenome
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Nakatsuji N, Chuma S. Nakatsuji N, Chuma S. Nakatsuji N, Chuma S. Differentiation of mouse primordial germ cells into female or male germ cells. Differentiation of mouse primordial germ cells into female or male germ cells. Differentiation of mouse primordial germ cells into female or male germ cells. Int J Dev Biol. 2001;45(3):541-8. Int J Dev Biol. 2001;45(3):541-8. Int J Dev Biol. 2001;45(3):541-8. 公開
Tamura M, Kanno Y, Chuma S, Saito T, Nakatsuji N. Tamura M, Kanno Y, Chuma S, Saito T, Nakatsuji N. Tamura M, Kanno Y, Chuma S, Saito T, Nakatsuji N. Pod-1/Capsulin shows a sex- and stage-dependent expression pattern in the mouse gonad development and represses expression of Ad4BP/SF-1. Pod-1/Capsulin shows a sex- and stage-dependent expression pattern in the mouse gonad development and represses expression of Ad4BP/SF-1. Pod-1/Capsulin shows a sex- and stage-dependent expression pattern in the mouse gonad development and represses expression of Ad4BP/SF-1. Mech Dev. 2001 Apr;102(1-2):135-44. Mech Dev. 2001 Apr;102(1-2):135-44. Mech Dev. 2001 Apr;102(1-2):135-44. 公開
Chuma S, Nakatsuji N. Chuma S, Nakatsuji N. Chuma S, Nakatsuji N. Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling. Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling. Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling. Dev Biol. 2001 Jan 15;229(2):468-79. Dev Biol. 2001 Jan 15;229(2):468-79. Dev Biol. 2001 Jan 15;229(2):468-79. 公開
Huang Z, Tamura M, Sakurai T, Chuma S, Saito T, Nakatsuji N. Huang Z, Tamura M, Sakurai T, Chuma S, Saito T, Nakatsuji N. Huang Z, Tamura M, Sakurai T, Chuma S, Saito T, Nakatsuji N. In vivo transfection of testicular germ cells and transgenesis by using the mitochondrially localized jellyfish fluorescent protein gene. In vivo transfection of testicular germ cells and transgenesis by using the mitochondrially localized jellyfish fluorescent protein gene. In vivo transfection of testicular germ cells and transgenesis by using the mitochondrially localized jellyfish fluorescent protein gene. FEBS Lett. 2000 Dec 29;487(2):248-51. FEBS Lett. 2000 Dec 29;487(2):248-51. FEBS Lett. 2000 Dec 29;487(2):248-51. 公開
Kanno Y, Tamura M, Chuma S, Sakura T, Machida T, Nakatsuji N. Kanno Y, Tamura M, Chuma S, Sakura T, Machida T, Nakatsuji N. Kanno Y, Tamura M, Chuma S, Sakura T, Machida T, Nakatsuji N. A cystatin-related gene, testatin/cresp, shows male-specific expression in germ and somatic cells from the initial stage of murine gonadal sex-differentiation. A cystatin-related gene, testatin/cresp, shows male-specific expression in germ and somatic cells from the initial stage of murine gonadal sex-differentiation. A cystatin-related gene, testatin/cresp, shows male-specific expression in germ and somatic cells from the initial stage of murine gonadal sex-differentiation. Int J Dev Biol. 1999 Nov;43(8):777-84. Int J Dev Biol. 1999 Nov;43(8):777-84. Int J Dev Biol. 1999 Nov;43(8):777-84. 公開
Yoshimura T, Watanabe T, Kuramochi-Miyagawa S, Takemoto N, Shiromoto Y, Kudo A, Kanai-Azuma M, Tashiro F, Miyazaki S, Katanaya A, Chuma S, Miyazaki JI. Yoshimura T, Watanabe T, Kuramochi-Miyagawa S, Takemoto N, Shiromoto Y, Kudo A, Kanai-Azuma M, Tashiro F, Miyazaki S, Katanaya A, Chuma S, Miyazaki JI. Yoshimura T, Watanabe T, Kuramochi-Miyagawa S, Takemoto N, Shiromoto Y, Kudo A, Kanai-Azuma M, Tashiro F, Miyazaki S, Katanaya A, Chuma S, Miyazaki JI. Mouse GTSF1 is an essential factor for secondary piRNA biogenesis. Mouse GTSF1 is an essential factor for secondary piRNA biogenesis. Mouse GTSF1 is an essential factor for secondary piRNA biogenesis. EMBO Rep. 2018 Apr;19(4). pii: e42054. doi: 10.15252/embr.201642054. Epub 2018 Feb 7. EMBO Rep. 2018 Apr;19(4). pii: e42054. doi: 10.15252/embr.201642054. Epub 2018 Feb 7. EMBO Rep. 2018 Apr;19(4). pii: e42054. doi: 10.15252/embr.201642054. Epub 2018 Feb 7. 公開
Mochizuki AL, Katanaya A, Hayashi E, Hosokawa M, Moribe E, Motegi A, Ishiai M, Takata M, Kondoh G, Watanabe H, Nakatsuji N, Chuma S. Mochizuki AL, Katanaya A, Hayashi E, Hosokawa M, Moribe E, Motegi A, Ishiai M, Takata M, Kondoh G, Watanabe H, Nakatsuji N, Chuma S. Mochizuki AL, Katanaya A, Hayashi E, Hosokawa M, Moribe E, Motegi A, Ishiai M, Takata M, Kondoh G, Watanabe H, Nakatsuji N, Chuma S. PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice. PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice. PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice. Mol Cell Biol. 2017 Nov 13;37(23). pii: e00117-17. doi: 10.1128/MCB.00117-17. Print 2017 Dec 1. Mol Cell Biol. 2017 Nov 13;37(23). pii: e00117-17. doi: 10.1128/MCB.00117-17. Print 2017 Dec 1. Mol Cell Biol. 2017 Nov 13;37(23). pii: e00117-17. doi: 10.1128/MCB.00117-17. Print 2017 Dec 1. 公開
Kabayama Y, Toh H, Katanaya A, Sakurai T, Chuma S, Kuramochi-Miyagawa S, Saga Y, Nakano T, Sasaki H. Kabayama Y, Toh H, Katanaya A, Sakurai T, Chuma S, Kuramochi-Miyagawa S, Saga Y, Nakano T, Sasaki H. Kabayama Y, Toh H, Katanaya A, Sakurai T, Chuma S, Kuramochi-Miyagawa S, Saga Y, Nakano T, Sasaki H. Roles of MIWI, MILI and PLD6 in small RNA regulation in mouse growing oocytes. Roles of MIWI, MILI and PLD6 in small RNA regulation in mouse growing oocytes. Roles of MIWI, MILI and PLD6 in small RNA regulation in mouse growing oocytes. Nucleic Acids Res. 2017 May 19;45(9):5387-5398. doi: 10.1093/nar/gkx027. Nucleic Acids Res. 2017 May 19;45(9):5387-5398. doi: 10.1093/nar/gkx027. Nucleic Acids Res. 2017 May 19;45(9):5387-5398. doi: 10.1093/nar/gkx027. 公開
Inoue H, Ogonuki N, Hirose M, Hatanaka Y, Matoba S, Chuma S, Kobayashi K, Wakana S, Noguchi J, Inoue K, Tanemura K, Ogura A. Inoue H, Ogonuki N, Hirose M, Hatanaka Y, Matoba S, Chuma S, Kobayashi K, Wakana S, Noguchi J, Inoue K, Tanemura K, Ogura A. Inoue H, Ogonuki N, Hirose M, Hatanaka Y, Matoba S, Chuma S, Kobayashi K, Wakana S, Noguchi J, Inoue K, Tanemura K, Ogura A. Mouse D1Pas1, a DEAD-box RNA helicase, is required for the completion of first meiotic prophase in male germ cells. Mouse D1Pas1, a DEAD-box RNA helicase, is required for the completion of first meiotic prophase in male germ cells. Mouse D1Pas1, a DEAD-box RNA helicase, is required for the completion of first meiotic prophase in male germ cells. Biochem Biophys Res Commun. 2016 Sep 16;478(2):592-8. doi: 10.1016/j.bbrc.2016.07.109. Epub 2016 Jul 27. Biochem Biophys Res Commun. 2016 Sep 16;478(2):592-8. doi: 10.1016/j.bbrc.2016.07.109. Epub 2016 Jul 27. Biochem Biophys Res Commun. 2016 Sep 16;478(2):592-8. doi: 10.1016/j.bbrc.2016.07.109. Epub 2016 Jul 27. 公開
Ghobrial IM, Redd R, Armand P, Banwait R, Boswell E, Chuma S, Huynh D, Sacco A, Roccaro AM, Perilla-Glen A, Noonan K, MacNabb M, Leblebjian H, Warren D, Henrick P, Castillo JJ, Richardson PG, Matous J, Weller E, Treon SP. Ghobrial IM, Redd R, Armand P, Banwait R, Boswell E, Chuma S, Huynh D, Sacco A, Roccaro AM, Perilla-Glen A, Noonan K, MacNabb M, Leblebjian H, Warren D, Henrick P, Castillo JJ, Richardson PG, Matous J, Weller E, Treon SP. Ghobrial IM, Redd R, Armand P, Banwait R, Boswell E, Chuma S, Huynh D, Sacco A, Roccaro AM, Perilla-Glen A, Noonan K, MacNabb M, Leblebjian H, Warren D, Henrick P, Castillo JJ, Richardson PG, Matous J, Weller E, Treon SP. Phase I/II trial of everolimus in combination with bortezomib and rituximab (RVR) in relapsed/refractory Waldenstrom macroglobulinemia. Phase I/II trial of everolimus in combination with bortezomib and rituximab (RVR) in relapsed/refractory Waldenstrom macroglobulinemia. Phase I/II trial of everolimus in combination with bortezomib and rituximab (RVR) in relapsed/refractory Waldenstrom macroglobulinemia. Leukemia. 2015 Dec;29(12):2338-46. doi: 10.1038/leu.2015.164. Epub 2015 Jul 3. Leukemia. 2015 Dec;29(12):2338-46. doi: 10.1038/leu.2015.164. Epub 2015 Jul 3. Leukemia. 2015 Dec;29(12):2338-46. doi: 10.1038/leu.2015.164. Epub 2015 Jul 3. 公開
Ichiyanagi T, Ichiyanagi K, Ogawa A, Kuramochi-Miyagawa S, Nakano T, Chuma S, Sasaki H, Udono H. Ichiyanagi T, Ichiyanagi K, Ogawa A, Kuramochi-Miyagawa S, Nakano T, Chuma S, Sasaki H, Udono H. Ichiyanagi T, Ichiyanagi K, Ogawa A, Kuramochi-Miyagawa S, Nakano T, Chuma S, Sasaki H, Udono H. HSP90 plays an important role in piRNA biogenesis and retrotransposon repression in mouse. HSP90 plays an important role in piRNA biogenesis and retrotransposon repression in mouse. HSP90 plays an important role in piRNA biogenesis and retrotransposon repression in mouse. Nucleic Acids Res. 2014 Oct 29;42(19):11903-11. doi: 10.1093/nar/gku881. Epub 2014 Sep 27. Nucleic Acids Res. 2014 Oct 29;42(19):11903-11. doi: 10.1093/nar/gku881. Epub 2014 Sep 27. Nucleic Acids Res. 2014 Oct 29;42(19):11903-11. doi: 10.1093/nar/gku881. Epub 2014 Sep 27. 公開
Chuma S. Chuma S. Chuma S. LINE-1 of evidence for fetal oocyte attrition by retrotransposon. LINE-1 of evidence for fetal oocyte attrition by retrotransposon. LINE-1 of evidence for fetal oocyte attrition by retrotransposon. Dev Cell. 2014 Jun 9;29(5):501-502. doi: 10.1016/j.devcel.2014.05.017. Dev Cell. 2014 Jun 9;29(5):501-502. doi: 10.1016/j.devcel.2014.05.017. Dev Cell. 2014 Jun 9;29(5):501-502. doi: 10.1016/j.devcel.2014.05.017. 公開
Treon SP, Tripsas CK, Meid K, Kanan S, Sheehy P, Chuma S, Xu L, Cao Y, Yang G, Liu X, Patterson CJ, Warren D, Hunter ZR, Turnbull B, Ghobrial IM, Castillo JJ. Treon SP, Tripsas CK, Meid K, Kanan S, Sheehy P, Chuma S, Xu L, Cao Y, Yang G, Liu X, Patterson CJ, Warren D, Hunter ZR, Turnbull B, Ghobrial IM, Castillo JJ. Treon SP, Tripsas CK, Meid K, Kanan S, Sheehy P, Chuma S, Xu L, Cao Y, Yang G, Liu X, Patterson CJ, Warren D, Hunter ZR, Turnbull B, Ghobrial IM, Castillo JJ. Carfilzomib, rituximab, and dexamethasone (CaRD) treatment offers a neuropathy-sparing approach for treating Waldenström's macroglobulinemia. Carfilzomib, rituximab, and dexamethasone (CaRD) treatment offers a neuropathy-sparing approach for treating Waldenström's macroglobulinemia. Carfilzomib, rituximab, and dexamethasone (CaRD) treatment offers a neuropathy-sparing approach for treating Waldenström's macroglobulinemia. Blood. 2014 Jul 24;124(4):503-10. doi: 10.1182/blood-2014-03-566273. Epub 2014 May 23. Blood. 2014 Jul 24;124(4):503-10. doi: 10.1182/blood-2014-03-566273. Epub 2014 May 23. Blood. 2014 Jul 24;124(4):503-10. doi: 10.1182/blood-2014-03-566273. Epub 2014 May 23. 公開
Ghobrial IM, Witzig TE, Gertz M, LaPlant B, Hayman S, Camoriano J, Lacy M, Bergsagel PL, Chuma S, DeAngelo D, Treon SP. Ghobrial IM, Witzig TE, Gertz M, LaPlant B, Hayman S, Camoriano J, Lacy M, Bergsagel PL, Chuma S, DeAngelo D, Treon SP. Ghobrial IM, Witzig TE, Gertz M, LaPlant B, Hayman S, Camoriano J, Lacy M, Bergsagel PL, Chuma S, DeAngelo D, Treon SP. Long-term results of the phase II trial of the oral mTOR inhibitor everolimus (RAD001) in relapsed or refractory Waldenstrom Macroglobulinemia. Long-term results of the phase II trial of the oral mTOR inhibitor everolimus (RAD001) in relapsed or refractory Waldenstrom Macroglobulinemia. Long-term results of the phase II trial of the oral mTOR inhibitor everolimus (RAD001) in relapsed or refractory Waldenstrom Macroglobulinemia. Am J Hematol. 2014 Mar;89(3):237-42. Am J Hematol. 2014 Mar;89(3):237-42. Am J Hematol. 2014 Mar;89(3):237-42. 公開
Pandey RR, Tokuzawa Y, Yang Z, Hayashi E, Ichisaka T, Kajita S, Asano Y, Kunieda T, Sachidanandam R, Chuma S, Yamanaka S, Pillai RS. Pandey RR, Tokuzawa Y, Yang Z, Hayashi E, Ichisaka T, Kajita S, Asano Y, Kunieda T, Sachidanandam R, Chuma S, Yamanaka S, Pillai RS. Pandey RR, Tokuzawa Y, Yang Z, Hayashi E, Ichisaka T, Kajita S, Asano Y, Kunieda T, Sachidanandam R, Chuma S, Yamanaka S, Pillai RS. Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice. Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice. Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7. doi: 10.1073/pnas.1316316110. Epub 2013 Sep 25. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7. doi: 10.1073/pnas.1316316110. Epub 2013 Sep 25. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7. doi: 10.1073/pnas.1316316110. Epub 2013 Sep 25. 公開
Lim AK, Lorthongpanich C, Chew TG, Tan CW, Shue YT, Balu S, Gounko N, Kuramochi-Miyagawa S, Matzuk MM, Chuma S, Messerschmidt DM, Solter D, Knowles BB. Lim AK, Lorthongpanich C, Chew TG, Tan CW, Shue YT, Balu S, Gounko N, Kuramochi-Miyagawa S, Matzuk MM, Chuma S, Messerschmidt DM, Solter D, Knowles BB. Lim AK, Lorthongpanich C, Chew TG, Tan CW, Shue YT, Balu S, Gounko N, Kuramochi-Miyagawa S, Matzuk MM, Chuma S, Messerschmidt DM, Solter D, Knowles BB. The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles. The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles. The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles. Development. 2013 Sep;140(18):3819-25. doi: 10.1242/dev.099184. Epub 2013 Aug 7. Development. 2013 Sep;140(18):3819-25. doi: 10.1242/dev.099184. Epub 2013 Aug 7. Development. 2013 Sep;140(18):3819-25. doi: 10.1242/dev.099184. Epub 2013 Aug 7. 公開
Shiromoto Y, Kuramochi-Miyagawa S, Daiba A, Chuma S, Katanaya A, Katsumata A, Nishimura K, Ohtaka M, Nakanishi M, Nakamura T, Yoshinaga K, Asada N, Nakamura S, Yasunaga T, Kojima-Kita K, Itou D, Kimura T, Nakano T. Shiromoto Y, Kuramochi-Miyagawa S, Daiba A, Chuma S, Katanaya A, Katsumata A, Nishimura K, Ohtaka M, Nakanishi M, Nakamura T, Yoshinaga K, Asada N, Nakamura S, Yasunaga T, Kojima-Kita K, Itou D, Kimura T, Nakano T. Shiromoto Y, Kuramochi-Miyagawa S, Daiba A, Chuma S, Katanaya A, Katsumata A, Nishimura K, Ohtaka M, Nakanishi M, Nakamura T, Yoshinaga K, Asada N, Nakamura S, Yasunaga T, Kojima-Kita K, Itou D, Kimura T, Nakano T. GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells. GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells. GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells. RNA. 2013 Jun;19(6):803-10. doi: 10.1261/rna.038521.113. Epub 2013 Apr 23. RNA. 2013 Jun;19(6):803-10. doi: 10.1261/rna.038521.113. Epub 2013 Apr 23. RNA. 2013 Jun;19(6):803-10. doi: 10.1261/rna.038521.113. Epub 2013 Apr 23. 公開
Ghobrial IM, Campigotto F, Murphy TJ, Boswell EN, Banwait R, Azab F, Chuma S, Kunsman J, Donovan A, Masood F, Warren D, Rodig S, Anderson KC, Richardson PG, Weller E, Matous J. Ghobrial IM, Campigotto F, Murphy TJ, Boswell EN, Banwait R, Azab F, Chuma S, Kunsman J, Donovan A, Masood F, Warren D, Rodig S, Anderson KC, Richardson PG, Weller E, Matous J. Ghobrial IM, Campigotto F, Murphy TJ, Boswell EN, Banwait R, Azab F, Chuma S, Kunsman J, Donovan A, Masood F, Warren D, Rodig S, Anderson KC, Richardson PG, Weller E, Matous J. Results of a phase 2 trial of the single-agent histone deacetylase inhibitor panobinostat in patients with relapsed/refractory Waldenström macroglobulinemia. Results of a phase 2 trial of the single-agent histone deacetylase inhibitor panobinostat in patients with relapsed/refractory Waldenström macroglobulinemia. Results of a phase 2 trial of the single-agent histone deacetylase inhibitor panobinostat in patients with relapsed/refractory Waldenström macroglobulinemia. Blood. 2013 Feb 21;121(8):1296-303. doi: 10.1182/blood-2012-06-439307. Epub 2013 Jan 3. Blood. 2013 Feb 21;121(8):1296-303. doi: 10.1182/blood-2012-06-439307. Epub 2013 Jan 3. Blood. 2013 Feb 21;121(8):1296-303. doi: 10.1182/blood-2012-06-439307. Epub 2013 Jan 3. 公開
Chuma S, Nakano T. Chuma S, Nakano T. Chuma S, Nakano T. piRNA and spermatogenesis in mice. piRNA and spermatogenesis in mice. piRNA and spermatogenesis in mice. Philos Trans R Soc Lond B Biol Sci. 2013 Jan 5;368(1609):20110338. doi: 10.1098/rstb.2011.0338. Review. Philos Trans R Soc Lond B Biol Sci. 2013 Jan 5;368(1609):20110338. doi: 10.1098/rstb.2011.0338. Review. Philos Trans R Soc Lond B Biol Sci. 2013 Jan 5;368(1609):20110338. doi: 10.1098/rstb.2011.0338. Review. 公開
Xiol J, Cora E, Koglgruber R, Chuma S, Subramanian S, Hosokawa M, Reuter M, Yang Z, Berninger P, Palencia A, Benes V, Penninger J, Sachidanandam R, Pillai RS. Xiol J, Cora E, Koglgruber R, Chuma S, Subramanian S, Hosokawa M, Reuter M, Yang Z, Berninger P, Palencia A, Benes V, Penninger J, Sachidanandam R, Pillai RS. Xiol J, Cora E, Koglgruber R, Chuma S, Subramanian S, Hosokawa M, Reuter M, Yang Z, Berninger P, Palencia A, Benes V, Penninger J, Sachidanandam R, Pillai RS. A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing. A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing. A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing. Mol Cell. 2012 Sep 28;47(6):970-9. doi: 10.1016/j.molcel.2012.07.019. Epub 2012 Aug 16. Mol Cell. 2012 Sep 28;47(6):970-9. doi: 10.1016/j.molcel.2012.07.019. Epub 2012 Aug 16. Mol Cell. 2012 Sep 28;47(6):970-9. doi: 10.1016/j.molcel.2012.07.019. Epub 2012 Aug 16. 公開
Pillai RS, Chuma S. Pillai RS, Chuma S. Pillai RS, Chuma S. piRNAs and their involvement in male germline development in mice. piRNAs and their involvement in male germline development in mice. piRNAs and their involvement in male germline development in mice. Dev Growth Differ. 2012 Jan;54(1):78-92. doi: 10.1111/j.1440-169X.2011.01320.x. Epub 2012 Jan 6. Review. Dev Growth Differ. 2012 Jan;54(1):78-92. doi: 10.1111/j.1440-169X.2011.01320.x. Epub 2012 Jan 6. Review. Dev Growth Differ. 2012 Jan;54(1):78-92. doi: 10.1111/j.1440-169X.2011.01320.x. Epub 2012 Jan 6. Review. 公開
Morozumi Y, Ino R, Takaku M, Hosokawa M, Chuma S, Kurumizaka H. Morozumi Y, Ino R, Takaku M, Hosokawa M, Chuma S, Kurumizaka H. Morozumi Y, Ino R, Takaku M, Hosokawa M, Chuma S, Kurumizaka H. Human PSF concentrates DNA and stimulates duplex capture in DMC1-mediated homologous pairing. Human PSF concentrates DNA and stimulates duplex capture in DMC1-mediated homologous pairing. Human PSF concentrates DNA and stimulates duplex capture in DMC1-mediated homologous pairing. Nucleic Acids Res. 2012 Apr;40(7):3031-41. doi: 10.1093/nar/gkr1229. Epub 2011 Dec 9. Nucleic Acids Res. 2012 Apr;40(7):3031-41. doi: 10.1093/nar/gkr1229. Epub 2011 Dec 9. Nucleic Acids Res. 2012 Apr;40(7):3031-41. doi: 10.1093/nar/gkr1229. Epub 2011 Dec 9. 公開
Reuter M, Berninger P, Chuma S, Shah H, Hosokawa M, Funaya C, Antony C, Sachidanandam R, Pillai RS. Reuter M, Berninger P, Chuma S, Shah H, Hosokawa M, Funaya C, Antony C, Sachidanandam R, Pillai RS. Reuter M, Berninger P, Chuma S, Shah H, Hosokawa M, Funaya C, Antony C, Sachidanandam R, Pillai RS. Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing. Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing. Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing. Nature. 2011 Nov 27;480(7376):264-7. doi: 10.1038/nature10672. Nature. 2011 Nov 27;480(7376):264-7. doi: 10.1038/nature10672. Nature. 2011 Nov 27;480(7376):264-7. doi: 10.1038/nature10672. 公開
Tanaka T, Hosokawa M, Vagin VV, Reuter M, Hayashi E, Mochizuki AL, Kitamura K, Yamanaka H, Kondoh G, Okawa K, Kuramochi-Miyagawa S, Nakano T, Sachidanandam R, Hannon GJ, Pillai RS, Nakatsuji N, Chuma S. Tanaka T, Hosokawa M, Vagin VV, Reuter M, Hayashi E, Mochizuki AL, Kitamura K, Yamanaka H, Kondoh G, Okawa K, Kuramochi-Miyagawa S, Nakano T, Sachidanandam R, Hannon GJ, Pillai RS, Nakatsuji N, Chuma S. Tanaka T, Hosokawa M, Vagin VV, Reuter M, Hayashi E, Mochizuki AL, Kitamura K, Yamanaka H, Kondoh G, Okawa K, Kuramochi-Miyagawa S, Nakano T, Sachidanandam R, Hannon GJ, Pillai RS, Nakatsuji N, Chuma S. Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10579-84. doi: 10.1073/pnas.1015447108. Epub 2011 Jun 13. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10579-84. doi: 10.1073/pnas.1015447108. Epub 2011 Jun 13. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10579-84. doi: 10.1073/pnas.1015447108. Epub 2011 Jun 13. 公開
Watanabe T, Chuma S, Yamamoto Y, Kuramochi-Miyagawa S, Totoki Y, Toyoda A, Hoki Y, Fujiyama A, Shibata T, Sado T, Noce T, Nakano T, Nakatsuji N, Lin H, Sasaki H. Watanabe T, Chuma S, Yamamoto Y, Kuramochi-Miyagawa S, Totoki Y, Toyoda A, Hoki Y, Fujiyama A, Shibata T, Sado T, Noce T, Nakano T, Nakatsuji N, Lin H, Sasaki H. Watanabe T, Chuma S, Yamamoto Y, Kuramochi-Miyagawa S, Totoki Y, Toyoda A, Hoki Y, Fujiyama A, Shibata T, Sado T, Noce T, Nakano T, Nakatsuji N, Lin H, Sasaki H. MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline. MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline. MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline. Dev Cell. 2011 Mar 15;20(3):364-75. doi: 10.1016/j.devcel.2011.01.005. Dev Cell. 2011 Mar 15;20(3):364-75. doi: 10.1016/j.devcel.2011.01.005. Dev Cell. 2011 Mar 15;20(3):364-75. doi: 10.1016/j.devcel.2011.01.005. 公開
Yabuta Y, Ohta H, Abe T, Kurimoto K, Chuma S, Saitou M. Yabuta Y, Ohta H, Abe T, Kurimoto K, Chuma S, Saitou M. Yabuta Y, Ohta H, Abe T, Kurimoto K, Chuma S, Saitou M. TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice. TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice. TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice. J Cell Biol. 2011 Mar 7;192(5):781-95. doi: 10.1083/jcb.201009043. J Cell Biol. 2011 Mar 7;192(5):781-95. doi: 10.1083/jcb.201009043. J Cell Biol. 2011 Mar 7;192(5):781-95. doi: 10.1083/jcb.201009043. 公開
Ghobrial IM, Weller E, Vij R, Munshi NC, Banwait R, Bagshaw M, Schlossman R, Leduc R, Chuma S, Kunsman J, Laubach J, Jakubowiak AJ, Maiso P, Roccaro A, Armand P, Dollard A, Warren D, Harris B, Poon T, Sam A, Rodig S, Anderson KC, et al. Ghobrial IM, Weller E, Vij R, Munshi NC, Banwait R, Bagshaw M, Schlossman R, Leduc R, Chuma S, Kunsman J, Laubach J, Jakubowiak AJ, Maiso P, Roccaro A, Armand P, Dollard A, Warren D, Harris B, Poon T, Sam A, Rodig S, Anderson KC, et al. Ghobrial IM, Weller E, Vij R, Munshi NC, Banwait R, Bagshaw M, Schlossman R, Leduc R, Chuma S, Kunsman J, Laubach J, Jakubowiak AJ, Maiso P, Roccaro A, Armand P, Dollard A, Warren D, Harris B, Poon T, Sam A, Rodig S, Anderson KC, et al. Weekly bortezomib in combination with temsirolimus in relapsed or relapsed and refractory multiple myeloma: a multicentre, phase 1/2, open-label, dose-escalation study. Weekly bortezomib in combination with temsirolimus in relapsed or relapsed and refractory multiple myeloma: a multicentre, phase 1/2, open-label, dose-escalation study. Weekly bortezomib in combination with temsirolimus in relapsed or relapsed and refractory multiple myeloma: a multicentre, phase 1/2, open-label, dose-escalation study. Lancet Oncol. 2011 Mar;12(3):263-72. doi: 10.1016/S1470-2045(11)70028-6. Epub 2011 Feb 21. Lancet Oncol. 2011 Mar;12(3):263-72. doi: 10.1016/S1470-2045(11)70028-6. Epub 2011 Feb 21. Lancet Oncol. 2011 Mar;12(3):263-72. doi: 10.1016/S1470-2045(11)70028-6. Epub 2011 Feb 21. 公開
Ghobrial IM, Xie W, Padmanabhan S, Badros A, Rourke M, Leduc R, Chuma S, Kunsman J, Warren D, Poon T, Harris B, Sam A, Anderson KC, Richardson PG, Treon SP, Weller E, Matous J. Ghobrial IM, Xie W, Padmanabhan S, Badros A, Rourke M, Leduc R, Chuma S, Kunsman J, Warren D, Poon T, Harris B, Sam A, Anderson KC, Richardson PG, Treon SP, Weller E, Matous J. Ghobrial IM, Xie W, Padmanabhan S, Badros A, Rourke M, Leduc R, Chuma S, Kunsman J, Warren D, Poon T, Harris B, Sam A, Anderson KC, Richardson PG, Treon SP, Weller E, Matous J. Phase II trial of weekly bortezomib in combination with rituximab in untreated patients with Waldenström Macroglobulinemia. Phase II trial of weekly bortezomib in combination with rituximab in untreated patients with Waldenström Macroglobulinemia. Phase II trial of weekly bortezomib in combination with rituximab in untreated patients with Waldenström Macroglobulinemia. Am J Hematol. 2010 Sep;85(9):670-4. doi: 10.1002/ajh.21788. Am J Hematol. 2010 Sep;85(9):670-4. doi: 10.1002/ajh.21788. Am J Hematol. 2010 Sep;85(9):670-4. doi: 10.1002/ajh.21788. 公開
Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Takamatsu K, Chuma S, Kojima-Kita K, Shiromoto Y, Asada N, Toyoda A, Fujiyama A, Totoki Y, Shibata T, Kimura T, Nakatsuji N, Noce T, Sasaki H, Nakano T. Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Takamatsu K, Chuma S, Kojima-Kita K, Shiromoto Y, Asada N, Toyoda A, Fujiyama A, Totoki Y, Shibata T, Kimura T, Nakatsuji N, Noce T, Sasaki H, Nakano T. Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Takamatsu K, Chuma S, Kojima-Kita K, Shiromoto Y, Asada N, Toyoda A, Fujiyama A, Totoki Y, Shibata T, Kimura T, Nakatsuji N, Noce T, Sasaki H, Nakano T. MVH in piRNA processing and gene silencing of retrotransposons. MVH in piRNA processing and gene silencing of retrotransposons. MVH in piRNA processing and gene silencing of retrotransposons. Genes Dev. 2010 May;24(9):887-92. doi: 10.1101/gad.1902110. Genes Dev. 2010 May;24(9):887-92. doi: 10.1101/gad.1902110. Genes Dev. 2010 May;24(9):887-92. doi: 10.1101/gad.1902110. 公開
Ghobrial IM, Gertz M, Laplant B, Camoriano J, Hayman S, Lacy M, Chuma S, Harris B, Leduc R, Rourke M, Ansell SM, Deangelo D, Dispenzieri A, Bergsagel L, Reeder C, Anderson KC, Richardson PG, Treon SP, Witzig TE. Ghobrial IM, Gertz M, Laplant B, Camoriano J, Hayman S, Lacy M, Chuma S, Harris B, Leduc R, Rourke M, Ansell SM, Deangelo D, Dispenzieri A, Bergsagel L, Reeder C, Anderson KC, Richardson PG, Treon SP, Witzig TE. Ghobrial IM, Gertz M, Laplant B, Camoriano J, Hayman S, Lacy M, Chuma S, Harris B, Leduc R, Rourke M, Ansell SM, Deangelo D, Dispenzieri A, Bergsagel L, Reeder C, Anderson KC, Richardson PG, Treon SP, Witzig TE. Phase II trial of the oral mammalian target of rapamycin inhibitor everolimus in relapsed or refractory Waldenstrom macroglobulinemia. Phase II trial of the oral mammalian target of rapamycin inhibitor everolimus in relapsed or refractory Waldenstrom macroglobulinemia. Phase II trial of the oral mammalian target of rapamycin inhibitor everolimus in relapsed or refractory Waldenstrom macroglobulinemia. J Clin Oncol. 2010 Mar 10;28(8):1408-14. doi: 10.1200/JCO.2009.24.0994. Epub 2010 Feb 8. J Clin Oncol. 2010 Mar 10;28(8):1408-14. doi: 10.1200/JCO.2009.24.0994. Epub 2010 Feb 8. J Clin Oncol. 2010 Mar 10;28(8):1408-14. doi: 10.1200/JCO.2009.24.0994. Epub 2010 Feb 8. 公開
Ghobrial IM, Hong F, Padmanabhan S, Badros A, Rourke M, Leduc R, Chuma S, Kunsman J, Warren D, Harris B, Sam A, Anderson KC, Richardson PG, Treon SP, Weller E, Matous J. Ghobrial IM, Hong F, Padmanabhan S, Badros A, Rourke M, Leduc R, Chuma S, Kunsman J, Warren D, Harris B, Sam A, Anderson KC, Richardson PG, Treon SP, Weller E, Matous J. Ghobrial IM, Hong F, Padmanabhan S, Badros A, Rourke M, Leduc R, Chuma S, Kunsman J, Warren D, Harris B, Sam A, Anderson KC, Richardson PG, Treon SP, Weller E, Matous J. Phase II trial of weekly bortezomib in combination with rituximab in relapsed or relapsed and refractory Waldenstrom macroglobulinemia. Phase II trial of weekly bortezomib in combination with rituximab in relapsed or relapsed and refractory Waldenstrom macroglobulinemia. Phase II trial of weekly bortezomib in combination with rituximab in relapsed or relapsed and refractory Waldenstrom macroglobulinemia. J Clin Oncol. 2010 Mar 10;28(8):1422-8. doi: 10.1200/JCO.2009.25.3237. Epub 2010 Feb 8. J Clin Oncol. 2010 Mar 10;28(8):1422-8. doi: 10.1200/JCO.2009.25.3237. Epub 2010 Feb 8. J Clin Oncol. 2010 Mar 10;28(8):1422-8. doi: 10.1200/JCO.2009.25.3237. Epub 2010 Feb 8. 公開
Ghobrial IM, Roccaro A, Hong F, Weller E, Rubin N, Leduc R, Rourke M, Chuma S, Sacco A, Jia X, Azab F, Azab AK, Rodig S, Warren D, Harris B, Varticovski L, Sportelli P, Leleu X, Anderson KC, Richardson PG. Ghobrial IM, Roccaro A, Hong F, Weller E, Rubin N, Leduc R, Rourke M, Chuma S, Sacco A, Jia X, Azab F, Azab AK, Rodig S, Warren D, Harris B, Varticovski L, Sportelli P, Leleu X, Anderson KC, Richardson PG. Ghobrial IM, Roccaro A, Hong F, Weller E, Rubin N, Leduc R, Rourke M, Chuma S, Sacco A, Jia X, Azab F, Azab AK, Rodig S, Warren D, Harris B, Varticovski L, Sportelli P, Leleu X, Anderson KC, Richardson PG. Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia. Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia. Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia. Clin Cancer Res. 2010 Feb 1;16(3):1033-41. doi: 10.1158/1078-0432.CCR-09-1837. Epub 2010 Jan 26. Clin Cancer Res. 2010 Feb 1;16(3):1033-41. doi: 10.1158/1078-0432.CCR-09-1837. Epub 2010 Jan 26. Clin Cancer Res. 2010 Feb 1;16(3):1033-41. doi: 10.1158/1078-0432.CCR-09-1837. Epub 2010 Jan 26. 公開
Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, Kondoh G, Okawa K, Chujo T, Suzuki T, Hata K, Martin SL, Noce T, Kuramochi-Miyagawa S, Nakano T, Sasaki H, Pillai RS, Nakatsuji N, Chuma S. Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, Kondoh G, Okawa K, Chujo T, Suzuki T, Hata K, Martin SL, Noce T, Kuramochi-Miyagawa S, Nakano T, Sasaki H, Pillai RS, Nakatsuji N, Chuma S. Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, Kondoh G, Okawa K, Chujo T, Suzuki T, Hata K, Martin SL, Noce T, Kuramochi-Miyagawa S, Nakano T, Sasaki H, Pillai RS, Nakatsuji N, Chuma S. The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev Cell. 2009 Dec;17(6):775-87. doi: 10.1016/j.devcel.2009.10.012. Dev Cell. 2009 Dec;17(6):775-87. doi: 10.1016/j.devcel.2009.10.012. Dev Cell. 2009 Dec;17(6):775-87. doi: 10.1016/j.devcel.2009.10.012. 公開
Chuma S, Pillai RS. Chuma S, Pillai RS. Chuma S, Pillai RS. Retrotransposon silencing by piRNAs: ping-pong players mark their sub-cellular boundaries. Retrotransposon silencing by piRNAs: ping-pong players mark their sub-cellular boundaries. Retrotransposon silencing by piRNAs: ping-pong players mark their sub-cellular boundaries. PLoS Genet. 2009 Dec;5(12):e1000770. doi: 10.1371/journal.pgen.1000770. Epub 2009 Dec 11. No abstract available. PLoS Genet. 2009 Dec;5(12):e1000770. doi: 10.1371/journal.pgen.1000770. Epub 2009 Dec 11. No abstract available. PLoS Genet. 2009 Dec;5(12):e1000770. doi: 10.1371/journal.pgen.1000770. Epub 2009 Dec 11. No abstract available. 公開
Morimoto H, Kanatsu-Shinohara M, Takashima S, Chuma S, Nakatsuji N, Takehashi M, Shinohara T. Morimoto H, Kanatsu-Shinohara M, Takashima S, Chuma S, Nakatsuji N, Takehashi M, Shinohara T. Morimoto H, Kanatsu-Shinohara M, Takashima S, Chuma S, Nakatsuji N, Takehashi M, Shinohara T. Phenotypic plasticity of mouse spermatogonial stem cells. Phenotypic plasticity of mouse spermatogonial stem cells. Phenotypic plasticity of mouse spermatogonial stem cells. PLoS One. 2009 Nov 19;4(11):e7909. doi: 10.1371/journal.pone.0007909. PLoS One. 2009 Nov 19;4(11):e7909. doi: 10.1371/journal.pone.0007909. PLoS One. 2009 Nov 19;4(11):e7909. doi: 10.1371/journal.pone.0007909. 公開
Yamaji M, Tanaka T, Shigeta M, Chuma S, Saga Y, Saitou M. Yamaji M, Tanaka T, Shigeta M, Chuma S, Saga Y, Saitou M. Yamaji M, Tanaka T, Shigeta M, Chuma S, Saga Y, Saitou M. Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3. Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3. Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3. Reproduction. 2010 Feb;139(2):381-93. doi: 10.1530/REP-09-0373. Epub 2009 Oct 27. Reproduction. 2010 Feb;139(2):381-93. doi: 10.1530/REP-09-0373. Epub 2009 Oct 27. Reproduction. 2010 Feb;139(2):381-93. doi: 10.1530/REP-09-0373. Epub 2009 Oct 27. 公開
Kojima K, Kuramochi-Miyagawa S, Chuma S, Tanaka T, Nakatsuji N, Kimura T, Nakano T. Kojima K, Kuramochi-Miyagawa S, Chuma S, Tanaka T, Nakatsuji N, Kimura T, Nakano T. Kojima K, Kuramochi-Miyagawa S, Chuma S, Tanaka T, Nakatsuji N, Kimura T, Nakano T. Associations between PIWI proteins and TDRD1/MTR-1 are critical for integrated subcellular localization in murine male germ cells. Associations between PIWI proteins and TDRD1/MTR-1 are critical for integrated subcellular localization in murine male germ cells. Associations between PIWI proteins and TDRD1/MTR-1 are critical for integrated subcellular localization in murine male germ cells. Genes Cells. 2009 Oct;14(10):1155-65. doi: 10.1111/j.1365-2443.2009.01342.x. Epub 2009 Sep 7. Genes Cells. 2009 Oct;14(10):1155-65. doi: 10.1111/j.1365-2443.2009.01342.x. Epub 2009 Sep 7. Genes Cells. 2009 Oct;14(10):1155-65. doi: 10.1111/j.1365-2443.2009.01342.x. Epub 2009 Sep 7. 公開
Vagin VV, Wohlschlegel J, Qu J, Jonsson Z, Huang X, Chuma S, Girard A, Sachidanandam R, Hannon GJ, Aravin AA. Vagin VV, Wohlschlegel J, Qu J, Jonsson Z, Huang X, Chuma S, Girard A, Sachidanandam R, Hannon GJ, Aravin AA. Vagin VV, Wohlschlegel J, Qu J, Jonsson Z, Huang X, Chuma S, Girard A, Sachidanandam R, Hannon GJ, Aravin AA. Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev. 2009 Aug 1;23(15):1749-62. doi: 10.1101/gad.1814809. Epub 2009 Jul 7. Genes Dev. 2009 Aug 1;23(15):1749-62. doi: 10.1101/gad.1814809. Epub 2009 Jul 7. Genes Dev. 2009 Aug 1;23(15):1749-62. doi: 10.1101/gad.1814809. Epub 2009 Jul 7. 公開
Reuter M, Chuma S, Tanaka T, Franz T, Stark A, Pillai RS. Reuter M, Chuma S, Tanaka T, Franz T, Stark A, Pillai RS. Reuter M, Chuma S, Tanaka T, Franz T, Stark A, Pillai RS. Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile. Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile. Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile. Nat Struct Mol Biol. 2009 Jun;16(6):639-46. doi: 10.1038/nsmb.1615. Epub 2009 May 24. Nat Struct Mol Biol. 2009 Jun;16(6):639-46. doi: 10.1038/nsmb.1615. Epub 2009 May 24. Nat Struct Mol Biol. 2009 Jun;16(6):639-46. doi: 10.1038/nsmb.1615. Epub 2009 May 24. 公開
Yamauchi K, Hasegawa K, Chuma S, Nakatsuji N, Suemori H. Yamauchi K, Hasegawa K, Chuma S, Nakatsuji N, Suemori H. Yamauchi K, Hasegawa K, Chuma S, Nakatsuji N, Suemori H. In vitro germ cell differentiation from cynomolgus monkey embryonic stem cells. In vitro germ cell differentiation from cynomolgus monkey embryonic stem cells. In vitro germ cell differentiation from cynomolgus monkey embryonic stem cells. PLoS One. 2009;4(4):e5338. doi: 10.1371/journal.pone.0005338. Epub 2009 Apr 28. PLoS One. 2009;4(4):e5338. doi: 10.1371/journal.pone.0005338. Epub 2009 Apr 28. PLoS One. 2009;4(4):e5338. doi: 10.1371/journal.pone.0005338. Epub 2009 Apr 28. 公開
Wang J, Saxe JP, Tanaka T, Chuma S, Lin H. Wang J, Saxe JP, Tanaka T, Chuma S, Lin H. Wang J, Saxe JP, Tanaka T, Chuma S, Lin H. Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis. Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis. Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis. Curr Biol. 2009 Apr 28;19(8):640-4. doi: 10.1016/j.cub.2009.02.061. Epub 2009 Apr 2. Curr Biol. 2009 Apr 28;19(8):640-4. doi: 10.1016/j.cub.2009.02.061. Epub 2009 Apr 2. Curr Biol. 2009 Apr 28;19(8):640-4. doi: 10.1016/j.cub.2009.02.061. Epub 2009 Apr 2. 公開
Takashima S, Takehashi M, Lee J, Chuma S, Okano M, Hata K, Suetake I, Nakatsuji N, Miyoshi H, Tajima S, Tanaka Y, Toyokuni S, Sasaki H, Kanatsu-Shinohara M, Shinohara T. Takashima S, Takehashi M, Lee J, Chuma S, Okano M, Hata K, Suetake I, Nakatsuji N, Miyoshi H, Tajima S, Tanaka Y, Toyokuni S, Sasaki H, Kanatsu-Shinohara M, Shinohara T. Takashima S, Takehashi M, Lee J, Chuma S, Okano M, Hata K, Suetake I, Nakatsuji N, Miyoshi H, Tajima S, Tanaka Y, Toyokuni S, Sasaki H, Kanatsu-Shinohara M, Shinohara T. Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects. Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects. Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects. Biol Reprod. 2009 Jul;81(1):155-64. doi: 10.1095/biolreprod.108.074708. Epub 2009 Feb 18. Biol Reprod. 2009 Jul;81(1):155-64. doi: 10.1095/biolreprod.108.074708. Epub 2009 Feb 18. Biol Reprod. 2009 Jul;81(1):155-64. doi: 10.1095/biolreprod.108.074708. Epub 2009 Feb 18. 公開
Chuma S, Hosokawa M, Tanaka T, Nakatsuji N. Chuma S, Hosokawa M, Tanaka T, Nakatsuji N. Chuma S, Hosokawa M, Tanaka T, Nakatsuji N. Ultrastructural characterization of spermatogenesis and its evolutionary conservation in the germline: germinal granules in mammals. Ultrastructural characterization of spermatogenesis and its evolutionary conservation in the germline: germinal granules in mammals. Ultrastructural characterization of spermatogenesis and its evolutionary conservation in the germline: germinal granules in mammals. Mol Cell Endocrinol. 2009 Jul 10;306(1-2):17-23. doi: 10.1016/j.mce.2008.11.009. Epub 2008 Nov 21. Review. Mol Cell Endocrinol. 2009 Jul 10;306(1-2):17-23. doi: 10.1016/j.mce.2008.11.009. Epub 2008 Nov 21. Review. Mol Cell Endocrinol. 2009 Jul 10;306(1-2):17-23. doi: 10.1016/j.mce.2008.11.009. Epub 2008 Nov 21. Review. 公開
Kanatsu-Shinohara M, Takehashi M, Takashima S, Lee J, Morimoto H, Chuma S, Raducanu A, Nakatsuji N, Fässler R, Shinohara T. Kanatsu-Shinohara M, Takehashi M, Takashima S, Lee J, Morimoto H, Chuma S, Raducanu A, Nakatsuji N, Fässler R, Shinohara T. Kanatsu-Shinohara M, Takehashi M, Takashima S, Lee J, Morimoto H, Chuma S, Raducanu A, Nakatsuji N, Fässler R, Shinohara T. Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin. Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin. Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin. Cell Stem Cell. 2008 Nov 6;3(5):533-42. doi: 10.1016/j.stem.2008.08.002. Cell Stem Cell. 2008 Nov 6;3(5):533-42. doi: 10.1016/j.stem.2008.08.002. Cell Stem Cell. 2008 Nov 6;3(5):533-42. doi: 10.1016/j.stem.2008.08.002. 公開
Kanatsu-Shinohara M, Kato M, Takehashi M, Morimoto H, Takashima S, Chuma S, Nakatsuji N, Hirabayashi M, Shinohara T. Kanatsu-Shinohara M, Kato M, Takehashi M, Morimoto H, Takashima S, Chuma S, Nakatsuji N, Hirabayashi M, Shinohara T. Kanatsu-Shinohara M, Kato M, Takehashi M, Morimoto H, Takashima S, Chuma S, Nakatsuji N, Hirabayashi M, Shinohara T. Production of transgenic rats via lentiviral transduction and xenogeneic transplantation of spermatogonial stem cells. Production of transgenic rats via lentiviral transduction and xenogeneic transplantation of spermatogonial stem cells. Production of transgenic rats via lentiviral transduction and xenogeneic transplantation of spermatogonial stem cells. Biol Reprod. 2008 Dec;79(6):1121-8. doi: 10.1095/biolreprod.108.071159. Epub 2008 Aug 6. Biol Reprod. 2008 Dec;79(6):1121-8. doi: 10.1095/biolreprod.108.071159. Epub 2008 Aug 6. Biol Reprod. 2008 Dec;79(6):1121-8. doi: 10.1095/biolreprod.108.071159. Epub 2008 Aug 6. 公開
Kanatsu-Shinohara M, Muneto T, Lee J, Takenaka M, Chuma S, Nakatsuji N, Horiuchi T, Shinohara T. Kanatsu-Shinohara M, Muneto T, Lee J, Takenaka M, Chuma S, Nakatsuji N, Horiuchi T, Shinohara T. Kanatsu-Shinohara M, Muneto T, Lee J, Takenaka M, Chuma S, Nakatsuji N, Horiuchi T, Shinohara T. Long-term culture of male germline stem cells from hamster testes. Long-term culture of male germline stem cells from hamster testes. Long-term culture of male germline stem cells from hamster testes. Biol Reprod. 2008 Apr;78(4):611-7. Epub 2007 Dec 19. Biol Reprod. 2008 Apr;78(4):611-7. Epub 2007 Dec 19. Biol Reprod. 2008 Apr;78(4):611-7. Epub 2007 Dec 19. 公開
Chuma S, Nakatsuji N. Chuma S, Nakatsuji N. Chuma S, Nakatsuji N. [Germ granule in mammals and its structural and molecular conservation]. [Germ granule in mammals and its structural and molecular conservation]. [Germ granule in mammals and its structural and molecular conservation]. Tanpakushitsu Kakusan Koso. 2007 Dec;52(16 Suppl):2102-8. Review. Japanese. No abstract available. Tanpakushitsu Kakusan Koso. 2007 Dec;52(16 Suppl):2102-8. Review. Japanese. No abstract available. Tanpakushitsu Kakusan Koso. 2007 Dec;52(16 Suppl):2102-8. Review. Japanese. No abstract available. 公開
Hosokawa M, Shoji M, Kitamura K, Tanaka T, Noce T, Chuma S, Nakatsuji N. Hosokawa M, Shoji M, Kitamura K, Tanaka T, Noce T, Chuma S, Nakatsuji N. Hosokawa M, Shoji M, Kitamura K, Tanaka T, Noce T, Chuma S, Nakatsuji N. Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice. Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice. Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice. Dev Biol. 2007 Jan 1;301(1):38-52. Epub 2006 Nov 6. Dev Biol. 2007 Jan 1;301(1):38-52. Epub 2006 Nov 6. Dev Biol. 2007 Jan 1;301(1):38-52. Epub 2006 Nov 6. 公開
Chuma S, Hosokawa M, Kitamura K, Kasai S, Fujioka M, Hiyoshi M, Takamune K, Noce T, Nakatsuji N. Chuma S, Hosokawa M, Kitamura K, Kasai S, Fujioka M, Hiyoshi M, Takamune K, Noce T, Nakatsuji N. Chuma S, Hosokawa M, Kitamura K, Kasai S, Fujioka M, Hiyoshi M, Takamune K, Noce T, Nakatsuji N. Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice. Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice. Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15894-9. Epub 2006 Oct 12. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15894-9. Epub 2006 Oct 12. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15894-9. Epub 2006 Oct 12. 公開
Shinohara T, Kato M, Takehashi M, Lee J, Chuma S, Nakatsuji N, Kanatsu-Shinohara M, Hirabayashi M. Shinohara T, Kato M, Takehashi M, Lee J, Chuma S, Nakatsuji N, Kanatsu-Shinohara M, Hirabayashi M. Shinohara T, Kato M, Takehashi M, Lee J, Chuma S, Nakatsuji N, Kanatsu-Shinohara M, Hirabayashi M. Rats produced by interspecies spermatogonial transplantation in mice and in vitro microinsemination. Rats produced by interspecies spermatogonial transplantation in mice and in vitro microinsemination. Rats produced by interspecies spermatogonial transplantation in mice and in vitro microinsemination. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13624-8. Epub 2006 Aug 30. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13624-8. Epub 2006 Aug 30. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13624-8. Epub 2006 Aug 30. 公開
Hasegawa K, Chuma S, Tada T, Sakurai T, Tamura M, Suemori H, Nakatsuji N. Hasegawa K, Chuma S, Tada T, Sakurai T, Tamura M, Suemori H, Nakatsuji N. Hasegawa K, Chuma S, Tada T, Sakurai T, Tamura M, Suemori H, Nakatsuji N. Testatin transgenic and knockout mice exhibit normal sex-differentiation. Testatin transgenic and knockout mice exhibit normal sex-differentiation. Testatin transgenic and knockout mice exhibit normal sex-differentiation. Biochem Biophys Res Commun. 2006 Mar 10;341(2):369-75. Epub 2006 Jan 19. Biochem Biophys Res Commun. 2006 Mar 10;341(2):369-75. Epub 2006 Jan 19. Biochem Biophys Res Commun. 2006 Mar 10;341(2):369-75. Epub 2006 Jan 19. 公開
Pan J, Goodheart M, Chuma S, Nakatsuji N, Page DC, Wang PJ. Pan J, Goodheart M, Chuma S, Nakatsuji N, Page DC, Wang PJ. Pan J, Goodheart M, Chuma S, Nakatsuji N, Page DC, Wang PJ. RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis. RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis. RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis. Development. 2005 Sep;132(18):4029-39. Epub 2005 Aug 10. Development. 2005 Sep;132(18):4029-39. Epub 2005 Aug 10. Development. 2005 Sep;132(18):4029-39. Epub 2005 Aug 10. 公開
Shoji M, Chuma S, Yoshida K, Morita T, Nakatsuji N. Shoji M, Chuma S, Yoshida K, Morita T, Nakatsuji N. Shoji M, Chuma S, Yoshida K, Morita T, Nakatsuji N. RNA interference during spermatogenesis in mice. RNA interference during spermatogenesis in mice. RNA interference during spermatogenesis in mice. Dev Biol. 2005 Jun 15;282(2):524-34. Dev Biol. 2005 Jun 15;282(2):524-34. Dev Biol. 2005 Jun 15;282(2):524-34. 公開
Isotani A, Nakanishi T, Kobayashi S, Lee J, Chuma S, Nakatsuji N, Ishino F, Okabe M. Isotani A, Nakanishi T, Kobayashi S, Lee J, Chuma S, Nakatsuji N, Ishino F, Okabe M. Isotani A, Nakanishi T, Kobayashi S, Lee J, Chuma S, Nakatsuji N, Ishino F, Okabe M. Genomic imprinting of XX spermatogonia and XX oocytes recovered from XX<-->XY chimeric testes. Genomic imprinting of XX spermatogonia and XX oocytes recovered from XX<-->XY chimeric testes. Genomic imprinting of XX spermatogonia and XX oocytes recovered from XX<-->XY chimeric testes. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4039-44. Epub 2005 Mar 3. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4039-44. Epub 2005 Mar 3. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4039-44. Epub 2005 Mar 3. 公開
Chuma S, Kanatsu-Shinohara M, Inoue K, Ogonuki N, Miki H, Toyokuni S, Hosokawa M, Nakatsuji N, Ogura A, Shinohara T. Chuma S, Kanatsu-Shinohara M, Inoue K, Ogonuki N, Miki H, Toyokuni S, Hosokawa M, Nakatsuji N, Ogura A, Shinohara T. Chuma S, Kanatsu-Shinohara M, Inoue K, Ogonuki N, Miki H, Toyokuni S, Hosokawa M, Nakatsuji N, Ogura A, Shinohara T. Spermatogenesis from epiblast and primordial germ cells following transplantation into postnatal mouse testis. Spermatogenesis from epiblast and primordial germ cells following transplantation into postnatal mouse testis. Spermatogenesis from epiblast and primordial germ cells following transplantation into postnatal mouse testis. Development. 2005 Jan;132(1):117-22. Epub 2004 Dec 2. Development. 2005 Jan;132(1):117-22. Epub 2004 Dec 2. Development. 2005 Jan;132(1):117-22. Epub 2004 Dec 2. 公開
Kasai S, Chuma S, Motoyama N, Nakatsuji N. Kasai S, Chuma S, Motoyama N, Nakatsuji N. Kasai S, Chuma S, Motoyama N, Nakatsuji N. Haploinsufficiency of Bcl-x leads to male-specific defects in fetal germ cells: differential regulation of germ cell apoptosis between the sexes. Haploinsufficiency of Bcl-x leads to male-specific defects in fetal germ cells: differential regulation of germ cell apoptosis between the sexes. Haploinsufficiency of Bcl-x leads to male-specific defects in fetal germ cells: differential regulation of germ cell apoptosis between the sexes. Dev Biol. 2003 Dec 1;264(1):202-16. Dev Biol. 2003 Dec 1;264(1):202-16. Dev Biol. 2003 Dec 1;264(1):202-16. 公開
Chuma S, Hiyoshi M, Yamamoto A, Hosokawa M, Takamune K, Nakatsuji N. Chuma S, Hiyoshi M, Yamamoto A, Hosokawa M, Takamune K, Nakatsuji N. Chuma S, Hiyoshi M, Yamamoto A, Hosokawa M, Takamune K, Nakatsuji N. Mouse Tudor Repeat-1 (MTR-1) is a novel component of chromatoid bodies/nuages in male germ cells and forms a complex with snRNPs. Mouse Tudor Repeat-1 (MTR-1) is a novel component of chromatoid bodies/nuages in male germ cells and forms a complex with snRNPs. Mouse Tudor Repeat-1 (MTR-1) is a novel component of chromatoid bodies/nuages in male germ cells and forms a complex with snRNPs. Mech Dev. 2003 Sep;120(9):979-90. Mech Dev. 2003 Sep;120(9):979-90. Mech Dev. 2003 Sep;120(9):979-90. 公開

  • <<
  • >>
  • 表示
タイトル言語:
学術賞等
賞の名称(日本語) 賞の名称(英語) 授与組織名(日本語) 授与組織名(英語) 年月
DGD Editor-in-Chief Prize 日本発生生物学会 2015/05/
DGD Wiley-Blackwell Prize 日本発生生物学会 2013/05/
外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
若手研究(B) 生殖幹細胞の減数分裂移行と相同組換え制御の分子基盤 2008〜2009
特定領域研究 生殖幹細胞の増殖から減数分裂移行を制御するシグナル伝達クロストーク 2010〜2011
若手研究(B) 生殖幹細胞tudor−piwi複合体を介するsmall RNAーエピゲノム制御 2010〜2011
若手研究(B) 代表 生殖幹細胞tudor-piwi複合体を介するsmall RNAーエピゲノム制御 2010/2011〜
基盤研究(B) 代表 生殖細胞の減数分裂誘導とクロマチン構造転換の制御ネットワーク           2012〜2014
基盤研究(B) 代表 生殖細胞の減数分裂誘導とクロマチン構造転換の制御ネットワーク           2012/04/01〜2015/03/31
新学術領域研究(研究領域提案型) 代表 生殖幹細胞の増殖分化転換と核ダイナミクス連携 2013〜2014
新学術領域研究(研究領域提案型) 代表 生殖幹細胞の減数分裂移行を制御するゲノム-エピゲノムプログラム 2013〜2017
新学術領域研究(研究領域提案型) 代表 生殖幹細胞の減数分裂移行を制御するゲノム-エピゲノムプログラム (平成26年度分) 2014/04/01〜2015/03/31
基盤研究(B) 代表 生殖細胞の減数分裂誘導とクロマチン構造転換の制御ネットワーク (平成26年度分) 2014/04/01〜2015/03/31
新学術領域研究(研究領域提案型) 代表 生殖幹細胞の減数分裂移行を制御するゲノム-エピゲノムプログラム (平成27年度分) 2015/04/01〜2016/03/31
新学術領域研究(研究領域提案型) 代表 生殖幹細胞の減数分裂移行を制御するゲノム-エピゲノムプログラム (平成28年度分) 2016/04/01〜2017/03/31
新学術領域研究(研究領域提案型) 代表 生殖幹細胞の減数分裂移行を制御するゲノム-エピゲノムプログラム (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(B) 代表 生殖系列サイクルの遺伝的安定性の発生制御メカニズム 2018/04/〜2021/03/
基盤研究(B) 代表 生殖系列サイクルの遺伝的安定性の発生制御メカニズム (平成30年度分) 2018/04/01〜2019/03/31

  • <<
  • >>
  • 表示
外部資金:競争的資金・科学研究費補助金以外
制度名 代表者名 研究課題(日本語) 研究課題(英語) 期間
AMED 中辻憲夫 再生医療等の産業化に向けた評価基盤技術開発事業:ヒト多能性幹細胞由来の再生医療製品製造システムの開発 2014/04/〜2019/03/
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
発生再生ゼミナール Seminar on Developmental Biology and Regenerative Medicine 前期 全学共通科目 2015/04〜2016/03
発生再生医科学入門 Introduction to Developmental Biology and Regenerative Medicine 前期 全学共通科目 2015/04〜2016/03
全学運営(役職等)
役職名 期間
京都大学組み換えDNA実験安全委員会 委員 2013/04/01〜2015/03/31
組換えDNA実験安全委員会 1号委員 2015/04/01〜2017/03/31
組換えDNA実験安全委員会 1号委員 2017/04/01〜2019/03/31
組換えDNA実験安全委員会 委員 2019/04/01〜2021/03/31
部局運営(役職等)
役職名 期間
安全衛生委員会 委員
ヒトES細胞株樹立・分配事業検討委員会 委員 2016/10/01〜2019/09/30
動物実験委員会 委員
再生医科学動物実験専門委員会 委員 2016/10/01〜
化学物質管理委員会 委員 2016/10/01〜
兼業・利益相反審査委員会 2018/10/01〜