相川 知宏

最終更新日時: 2020/07/29 15:11:59

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氏名(漢字/フリガナ/アルファベット表記)
相川 知宏/アイカワ チヒロ/Aikawa, Chihiro
所属部署・職名(部局/所属/講座等/職名)
医学研究科/医学専攻感染・免疫学講座微生物感染症学/助教
学部兼担
部局 所属 講座等 職名
医学部
所属学会(国内)
学会名(日本語) 学会名(英語)
日本細菌学会 JAPANESE SOCIETY FOR BACTERIOLOGY
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士(生命科学) 北里大学
博士(生命科学) 東京大学
researchmap URL
https://researchmap.jp/7000011335
研究テーマ
(日本語)
細菌感染に対するオートファジーの誘導・制御機構の解析
(英語)
Analysis of the mechanisms of induction and regulation of anti-bacterial autophagy
研究概要
(日本語)
オートファジーは真核細胞において高度に保存され、オートファゴソームと呼ばれる二重膜が、細胞質内の内容物やダメージを受けた細胞小器官、あるいはタンパク質等を取り囲み、最終的にリソソームとの融合によりこれらを分解する機構である。近年、オートファジーは細胞内へと侵入した病原性細菌の分解機構(新たな免疫機構)として機能していることが明らかになったが、その制御や誘導機構は多くの部分で不明である。そこで、特に細胞内で菌体を認識する受容体群や相互作用分子の代表であるBeclin 1に焦点を当て、細菌に対するオートファジーの制御・誘導機構を明らかにするべく研究を行っている。
(英語)
Autophagy is a highly conserved biological process in eukaryotic cells and involves the formation of double membrane-enclosed vesicles, called autophagosomes, which sequester portions of cytoplasm, damaged organelles, or long-lived proteins and eventually deliver their contents for degradation in the lysosomal compartment. Recently autophagy has emerged as a host defense system against large variety of intracellular pathogens, however, the precise mechanisms responsible for regulation and induction of anti-bacterial autophagy are largely unknown. Therefore, especially focusing on intracellular receptors and thier important interacting partner Beclin1, I have been researching autophagy to find specific mechanisms of regulation and induction of anti-bacterial autophagy .
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
細菌学 Bacteriology
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Mototsugu Tanaka, Ryo Kinoshita-Daitoku, Kotaro Kiga, Takahito Sanada, Bo Zhu, Tokuju Okano, Chihiro Aikawa, Tamako Iida, Yoshitoshi Ogura, Tetsuya Hayashi, Koshu Okubo, Miho Kurosawa, Junichi Hirahashi, Toshihiko Suzuki, Ichiro Nakagawa, Masaomi Nangaku, Hitomi Mimuro Mototsugu Tanaka, Ryo Kinoshita-Daitoku, Kotaro Kiga, Takahito Sanada, Bo Zhu, Tokuju Okano, Chihiro Aikawa, Tamako Iida, Yoshitoshi Ogura, Tetsuya Hayashi, Koshu Okubo, Miho Kurosawa, Junichi Hirahashi, Toshihiko Suzuki, Ichiro Nakagawa, Masaomi Nangaku, Hitomi Mimuro Mototsugu Tanaka, Ryo Kinoshita-Daitoku, Kotaro Kiga, Takahito Sanada, Bo Zhu, Tokuju Okano, Chihiro Aikawa, Tamako Iida, Yoshitoshi Ogura, Tetsuya Hayashi, Koshu Okubo, Miho Kurosawa, Junichi Hirahashi, Toshihiko Suzuki, Ichiro Nakagawa, Masaomi Nangaku, Hitomi Mimuro Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps. Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps. Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps. Scientific reports, 10, 1, 3251-3251 Scientific reports, 10, 1, 3251-3251 Scientific reports, 10, 1, 3251-3251 2020/02/24 英語 公開
Hirotaka Toh, Takashi Nozawa, Atsuko Minowa-Nozawa, Miyako Hikichi, Shintaro Nakajima, Chihiro Aikawa, Ichiro Nakagawa Hirotaka Toh, Takashi Nozawa, Atsuko Minowa-Nozawa, Miyako Hikichi, Shintaro Nakajima, Chihiro Aikawa, Ichiro Nakagawa Hirotaka Toh, Takashi Nozawa, Atsuko Minowa-Nozawa, Miyako Hikichi, Shintaro Nakajima, Chihiro Aikawa, Ichiro Nakagawa Group A Streptococcus modulates RAB1- and PIK3C3 complex-dependent autophagy. Group A Streptococcus modulates RAB1- and PIK3C3 complex-dependent autophagy. Group A Streptococcus modulates RAB1- and PIK3C3 complex-dependent autophagy. Autophagy, 16, 2, 334-346 Autophagy, 16, 2, 334-346 Autophagy, 16, 2, 334-346 2020/02 英語 公開
Lin CY, Nozawa T, Minowa-Nozawa A, Toh H, Aikawa C, Nakagawa I Lin CY, Nozawa T, Minowa-Nozawa A, Toh H, Aikawa C, Nakagawa I Lin CY, Nozawa T, Minowa-Nozawa A, Toh H, Aikawa C, Nakagawa I LAMTOR2/LAMTOR1 complex is required for TAX1BP1-mediated xenophagy. LAMTOR2/LAMTOR1 complex is required for TAX1BP1-mediated xenophagy. LAMTOR2/LAMTOR1 complex is required for TAX1BP1-mediated xenophagy. Cellular microbiology, 21, 4, e12981 Cellular microbiology, 21, 4, e12981 Cellular microbiology, 21, 4, e12981 2019/04 公開
Yamada S, Shibasaki M, Murase K, Watanabe T, Aikawa C, Nozawa T, Nakagawa I Yamada S, Shibasaki M, Murase K, Watanabe T, Aikawa C, Nozawa T, Nakagawa I Yamada S, Shibasaki M, Murase K, Watanabe T, Aikawa C, Nozawa T, Nakagawa I Phylogenetic relationship of prophages is affected by CRISPR selection in Group A Streptococcus. Phylogenetic relationship of prophages is affected by CRISPR selection in Group A Streptococcus. Phylogenetic relationship of prophages is affected by CRISPR selection in Group A Streptococcus. BMC microbiology, 19, 1, 24 BMC microbiology, 19, 1, 24 BMC microbiology, 19, 1, 24 2019/01 公開
Nakajima K, Nozawa T, Minowa-Nozawa A, Toh H, Yamada S, Aikawa C, Nakagawa I Nakajima K, Nozawa T, Minowa-Nozawa A, Toh H, Yamada S, Aikawa C, Nakagawa I Nakajima K, Nozawa T, Minowa-Nozawa A, Toh H, Yamada S, Aikawa C, Nakagawa I RAB30 regulates PI4KB (phosphatidylinositol 4-kinase beta)-dependent autophagy against group A Streptococcus. RAB30 regulates PI4KB (phosphatidylinositol 4-kinase beta)-dependent autophagy against group A Streptococcus. RAB30 regulates PI4KB (phosphatidylinositol 4-kinase beta)-dependent autophagy against group A Streptococcus. Autophagy, 15, 3, 1-12 Autophagy, 15, 3, 1-12 Autophagy, 15, 3, 1-12 2018/10 公開
Chihiro Aikawa, Shintaro Nakajima, Miho Karimine, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Shunsuke Yamada, Ichiro Nakagawa Chihiro Aikawa, Shintaro Nakajima, Miho Karimine, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Shunsuke Yamada, Ichiro Nakagawa Chihiro Aikawa, Shintaro Nakajima, Miho Karimine, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Shunsuke Yamada, Ichiro Nakagawa NLRX1 Negatively Regulates Group A Streptococcus Invasion and Autophagy Induction by Interacting With the Beclin 1-UVRAG Complex. NLRX1 Negatively Regulates Group A Streptococcus Invasion and Autophagy Induction by Interacting With the Beclin 1-UVRAG Complex. NLRX1 Negatively Regulates Group A Streptococcus Invasion and Autophagy Induction by Interacting With the Beclin 1-UVRAG Complex. Frontiers in cellular and infection microbiology, 8, 403-403 Frontiers in cellular and infection microbiology, 8, 403-403 Frontiers in cellular and infection microbiology, 8, 403-403 2018 英語 公開
Masato Hoshino, Makoto Nakakido, Satoru Nagatoishi, Chihiro Aikawa, Ichiro Nakagawa, Kouhei Tsumoto Masato Hoshino, Makoto Nakakido, Satoru Nagatoishi, Chihiro Aikawa, Ichiro Nakagawa, Kouhei Tsumoto Masato Hoshino, Makoto Nakakido, Satoru Nagatoishi, Chihiro Aikawa, Ichiro Nakagawa, Kouhei Tsumoto Biophysical characterization of the interaction between heme and proteins responsible for heme transfer in Streptococcus pyogenes Biophysical characterization of the interaction between heme and proteins responsible for heme transfer in Streptococcus pyogenes Biophysical characterization of the interaction between heme and proteins responsible for heme transfer in Streptococcus pyogenes BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 493, 2, 1109-1114 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 493, 2, 1109-1114 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 493, 2, 1109-1114 2017/11 英語 研究論文(学術雑誌) 公開
Takashi Nozawa, Atsuko Minowa-Nozawa, Chihiro Aikawa, Ichiro Nakagawa Takashi Nozawa, Atsuko Minowa-Nozawa, Chihiro Aikawa, Ichiro Nakagawa Takashi Nozawa, Atsuko Minowa-Nozawa, Chihiro Aikawa, Ichiro Nakagawa The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes AUTOPHAGY, 13, 1, 57-69 AUTOPHAGY, 13, 1, 57-69 AUTOPHAGY, 13, 1, 57-69 2017 英語 研究論文(学術雑誌) 公開
Shintaro Nakajima, Chihiro Aikawe, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Ichiro Nakagawa Shintaro Nakajima, Chihiro Aikawe, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Ichiro Nakagawa Shintaro Nakajima, Chihiro Aikawe, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Ichiro Nakagawa Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG PLOS ONE, 12, 1, e0170138 PLOS ONE, 12, 1, e0170138 PLOS ONE, 12, 1, e0170138 2017/01 英語 研究論文(学術雑誌) 公開
Amonrattana Roobthaisong, Chihiro Aikawa, Takashi Nozawa, Fumito Maruyama, Ichiro Nakagawa Amonrattana Roobthaisong, Chihiro Aikawa, Takashi Nozawa, Fumito Maruyama, Ichiro Nakagawa Amonrattana Roobthaisong, Chihiro Aikawa, Takashi Nozawa, Fumito Maruyama, Ichiro Nakagawa YvqE and CovRS of Group A Streptococcus Play a Pivotal Role in Viability and Phenotypic Adaptations to Multiple Environmental Stresses YvqE and CovRS of Group A Streptococcus Play a Pivotal Role in Viability and Phenotypic Adaptations to Multiple Environmental Stresses YvqE and CovRS of Group A Streptococcus Play a Pivotal Role in Viability and Phenotypic Adaptations to Multiple Environmental Stresses PLOS ONE, 12, 1, e0170612 PLOS ONE, 12, 1, e0170612 PLOS ONE, 12, 1, e0170612 2017/01 英語 研究論文(学術雑誌) 公開
Takashi Nozawa, Chihiro Aikawa, Atsuko Minowa-Nozawa, Ichiro Nakagawa Takashi Nozawa, Chihiro Aikawa, Atsuko Minowa-Nozawa, Ichiro Nakagawa Takashi Nozawa, Chihiro Aikawa, Atsuko Minowa-Nozawa, Ichiro Nakagawa The intracellular microbial sensor NLRP4 directs Rho-actin signaling to facilitate Group A Streptococcus-containing autophagosome-like vacuole formation The intracellular microbial sensor NLRP4 directs Rho-actin signaling to facilitate Group A Streptococcus-containing autophagosome-like vacuole formation The intracellular microbial sensor NLRP4 directs Rho-actin signaling to facilitate Group A Streptococcus-containing autophagosome-like vacuole formation AUTOPHAGY, 13, 11, 1841-1854 AUTOPHAGY, 13, 11, 1841-1854 AUTOPHAGY, 13, 11, 1841-1854 2017 英語 研究論文(学術雑誌) 公開
Tejaswini Kulkarni, Chihiro Aikawa, Takashi Nozawa, Kazunori Murase, Fumito Maruyama, Ichiro Nakagawa Tejaswini Kulkarni, Chihiro Aikawa, Takashi Nozawa, Kazunori Murase, Fumito Maruyama, Ichiro Nakagawa Tejaswini Kulkarni, Chihiro Aikawa, Takashi Nozawa, Kazunori Murase, Fumito Maruyama, Ichiro Nakagawa DNA-based culture-independent analysis detects the presence of group a streptococcus in throat samples from healthy adults in Japan DNA-based culture-independent analysis detects the presence of group a streptococcus in throat samples from healthy adults in Japan DNA-based culture-independent analysis detects the presence of group a streptococcus in throat samples from healthy adults in Japan BMC MICROBIOLOGY, 16, 1, 237 BMC MICROBIOLOGY, 16, 1, 237 BMC MICROBIOLOGY, 16, 1, 237 2016/10 英語 研究論文(学術雑誌) 公開
Seiichiro Oda, Takashi Nozawa, Atsuko Nozawa-Minowa, Misako Tanaka, Chihiro Aikawa, Hiroyuki Harada, Ichiro Nakagawa Seiichiro Oda, Takashi Nozawa, Atsuko Nozawa-Minowa, Misako Tanaka, Chihiro Aikawa, Hiroyuki Harada, Ichiro Nakagawa Seiichiro Oda, Takashi Nozawa, Atsuko Nozawa-Minowa, Misako Tanaka, Chihiro Aikawa, Hiroyuki Harada, Ichiro Nakagawa Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes PLOS ONE, 11, 1, e0147061 PLOS ONE, 11, 1, e0147061 PLOS ONE, 11, 1, e0147061 2016/01 英語 研究論文(学術雑誌) 公開
Akiko Endo, Takayasu Watanabe, Nachiko Ogata, Takashi Nozawa, Chihiro Aikawa, Shinichi Arakawa, Fumito Maruyama, Yuichi Izumi, Ichiro Nakagawa Akiko Endo, Takayasu Watanabe, Nachiko Ogata, Takashi Nozawa, Chihiro Aikawa, Shinichi Arakawa, Fumito Maruyama, Yuichi Izumi, Ichiro Nakagawa Akiko Endo, Takayasu Watanabe, Nachiko Ogata, Takashi Nozawa, Chihiro Aikawa, Shinichi Arakawa, Fumito Maruyama, Yuichi Izumi, Ichiro Nakagawa Comparative genome analysis and identification of competitive and cooperative interactions in a polymicrobial disease Comparative genome analysis and identification of competitive and cooperative interactions in a polymicrobial disease Comparative genome analysis and identification of competitive and cooperative interactions in a polymicrobial disease ISME JOURNAL, 9, 3, 629-642 ISME JOURNAL, 9, 3, 629-642 ISME JOURNAL, 9, 3, 629-642 2015/03 英語 研究論文(学術雑誌) 公開
相川知宏, 丸山史人, 中川一路 相川知宏, 丸山史人, 中川一路 相川知宏, 丸山史人, 中川一路 CRISPR/Cas システム: 微生物における新規機能とゲノム編集適用例 CRISPR/Cas システム: 微生物における新規機能とゲノム編集適用例 CRISPR/Cas システム: 微生物における新規機能とゲノム編集適用例 日本乳酸菌学会誌, 26, 1, 14-21 日本乳酸菌学会誌, 26, 1, 14-21 日本乳酸菌学会誌, 26, 1, 14-21 2015 研究論文(学術雑誌) 公開
Bijaya Haobam, Takashi Nozawa, Atsuko Minowa-Nozawa, Misako Tanaka, Seiichiro Oda, Takayasu Watanabe, Chihiro Aikawa, Fumito Maruyama, Ichiro Nakagawa Bijaya Haobam, Takashi Nozawa, Atsuko Minowa-Nozawa, Misako Tanaka, Seiichiro Oda, Takayasu Watanabe, Chihiro Aikawa, Fumito Maruyama, Ichiro Nakagawa Bijaya Haobam, Takashi Nozawa, Atsuko Minowa-Nozawa, Misako Tanaka, Seiichiro Oda, Takayasu Watanabe, Chihiro Aikawa, Fumito Maruyama, Ichiro Nakagawa Rab17-mediated recycling endosomes contribute to autophagosome formation in response to Group A Streptococcus invasion Rab17-mediated recycling endosomes contribute to autophagosome formation in response to Group A Streptococcus invasion Rab17-mediated recycling endosomes contribute to autophagosome formation in response to Group A Streptococcus invasion CELLULAR MICROBIOLOGY, 16, 12, 1806-1821 CELLULAR MICROBIOLOGY, 16, 12, 1806-1821 CELLULAR MICROBIOLOGY, 16, 12, 1806-1821 2014/12 英語 研究論文(学術雑誌) 公開
Noriko Maruyama, Fumito Maruyama, Yasuo Takeuchi, Chihiro Aikawa, Yuichi Izumi, Ichiro Nakagawa Noriko Maruyama, Fumito Maruyama, Yasuo Takeuchi, Chihiro Aikawa, Yuichi Izumi, Ichiro Nakagawa Noriko Maruyama, Fumito Maruyama, Yasuo Takeuchi, Chihiro Aikawa, Yuichi Izumi, Ichiro Nakagawa Intraindividual variation in core microbiota in peri-implantitis and periodontitis Intraindividual variation in core microbiota in peri-implantitis and periodontitis Intraindividual variation in core microbiota in peri-implantitis and periodontitis SCIENTIFIC REPORTS, 4, 6602 SCIENTIFIC REPORTS, 4, 6602 SCIENTIFIC REPORTS, 4, 6602 2014/10 英語 研究論文(学術雑誌) 公開
Makoto Nakakido, Chihiro Aikawa, Ichiro Nakagawa, Kouhei Tsumoto Makoto Nakakido, Chihiro Aikawa, Ichiro Nakagawa, Kouhei Tsumoto Makoto Nakakido, Chihiro Aikawa, Ichiro Nakagawa, Kouhei Tsumoto The staphylococcal elastin-binding protein regulates zinc-dependent growth/biofilm formation The staphylococcal elastin-binding protein regulates zinc-dependent growth/biofilm formation The staphylococcal elastin-binding protein regulates zinc-dependent growth/biofilm formation JOURNAL OF BIOCHEMISTRY, 156, 3, 155-162 JOURNAL OF BIOCHEMISTRY, 156, 3, 155-162 JOURNAL OF BIOCHEMISTRY, 156, 3, 155-162 2014/09 英語 研究論文(学術雑誌) 公開
Abe H, Aikawa C, Nakabachi A, Miyakoshi M, Maruyama F Abe H, Aikawa C, Nakabachi A, Miyakoshi M, Maruyama F Abe H, Aikawa C, Nakabachi A, Miyakoshi M, Maruyama F [New insights from infection-specific gene expression network]. [New insights from infection-specific gene expression network]. [New insights from infection-specific gene expression network]. Nihon saikingaku zasshi. Japanese journal of bacteriology, 69, 3, 539-546 Nihon saikingaku zasshi. Japanese journal of bacteriology, 69, 3, 539-546 Nihon saikingaku zasshi. Japanese journal of bacteriology, 69, 3, 539-546 2014 公開
Chiaki Ito, Yohei Saito, Takashi Nozawa, Shigemoto Fujii, Tomohiro Sawa, Hirofumi Inoue, Tetsuro Matsunaga, Shahzada Khan, Soichiro Akashi, Ryota Hashimoto, Chihiro Aikawa, Eriko Takahashi, Hiroshi Sagara, Masaaki Komatsu, Keiji Tanaka, Takaaki Akaike, Ichiro Nakagawa, Hirokazu Arimoto Chiaki Ito, Yohei Saito, Takashi Nozawa, Shigemoto Fujii, Tomohiro Sawa, Hirofumi Inoue, Tetsuro Matsunaga, Shahzada Khan, Soichiro Akashi, Ryota Hashimoto, Chihiro Aikawa, Eriko Takahashi, Hiroshi Sagara, Masaaki Komatsu, Keiji Tanaka, Takaaki Akaike, Ichiro Nakagawa, Hirokazu Arimoto Chiaki Ito, Yohei Saito, Takashi Nozawa, Shigemoto Fujii, Tomohiro Sawa, Hirofumi Inoue, Tetsuro Matsunaga, Shahzada Khan, Soichiro Akashi, Ryota Hashimoto, Chihiro Aikawa, Eriko Takahashi, Hiroshi Sagara, Masaaki Komatsu, Keiji Tanaka, Takaaki Akaike, Ichiro Nakagawa, Hirokazu Arimoto Endogenous Nitrated Nucleotide Is a Key Mediator of Autophagy and Innate Defense against Bacteria Endogenous Nitrated Nucleotide Is a Key Mediator of Autophagy and Innate Defense against Bacteria Endogenous Nitrated Nucleotide Is a Key Mediator of Autophagy and Innate Defense against Bacteria MOLECULAR CELL, 52, 6, 794-804 MOLECULAR CELL, 52, 6, 794-804 MOLECULAR CELL, 52, 6, 794-804 2013/12 英語 研究論文(学術雑誌) 公開
Minegishi K, Aikawa C, Furukawa A, Watanabe T, Nakano T, Ogura Y, Ohtsubo Y, Kurokawa K, Hayashi T, Maruyama F, Nakagawa I, Eishi Y Minegishi K, Aikawa C, Furukawa A, Watanabe T, Nakano T, Ogura Y, Ohtsubo Y, Kurokawa K, Hayashi T, Maruyama F, Nakagawa I, Eishi Y Minegishi K, Aikawa C, Furukawa A, Watanabe T, Nakano T, Ogura Y, Ohtsubo Y, Kurokawa K, Hayashi T, Maruyama F, Nakagawa I, Eishi Y Complete Genome Sequence of a Propionibacterium acnes Isolate from a Sarcoidosis Patient. Complete Genome Sequence of a Propionibacterium acnes Isolate from a Sarcoidosis Patient. Complete Genome Sequence of a Propionibacterium acnes Isolate from a Sarcoidosis Patient. Genome announcements, 1, 1 Genome announcements, 1, 1 Genome announcements, 1, 1 2013/01 公開
Takayasu Watanabe, Takashi Nozawa, Chihiro Aikawa, Atsuo Amano, Fumito Maruyama, Ichiro Nakagawa Takayasu Watanabe, Takashi Nozawa, Chihiro Aikawa, Atsuo Amano, Fumito Maruyama, Ichiro Nakagawa Takayasu Watanabe, Takashi Nozawa, Chihiro Aikawa, Atsuo Amano, Fumito Maruyama, Ichiro Nakagawa CRISPR Regulation of Intraspecies Diversification by Limiting IS Transposition and Intercellular Recombination CRISPR Regulation of Intraspecies Diversification by Limiting IS Transposition and Intercellular Recombination CRISPR Regulation of Intraspecies Diversification by Limiting IS Transposition and Intercellular Recombination GENOME BIOLOGY AND EVOLUTION, 5, 6, 1099-1114 GENOME BIOLOGY AND EVOLUTION, 5, 6, 1099-1114 GENOME BIOLOGY AND EVOLUTION, 5, 6, 1099-1114 2013 英語 研究論文(学術雑誌) 公開
Takashi Nozawa, Chihiro Aikawa, Akira Goda, Fumito Maruyama, Shigeyuki Hamada, Ichiro Nakagawa Takashi Nozawa, Chihiro Aikawa, Akira Goda, Fumito Maruyama, Shigeyuki Hamada, Ichiro Nakagawa Takashi Nozawa, Chihiro Aikawa, Akira Goda, Fumito Maruyama, Shigeyuki Hamada, Ichiro Nakagawa The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection CELLULAR MICROBIOLOGY, 14, 8, 1149-1165 CELLULAR MICROBIOLOGY, 14, 8, 1149-1165 CELLULAR MICROBIOLOGY, 14, 8, 1149-1165 2012/08 英語 研究論文(学術雑誌) 公開
Chihiro Aikawa, Nayuta Furukawa, Takayasu Watanabe, Kana Minegishi, Asuka Furukawa, Yoshinobu Eishi, Kenshiro Oshima, Ken Kurokawa, Masahira Hattori, Kazuhiko Nakano, Fumito Maruyama, Ichiro Nakagawa, Takashi Ooshima Chihiro Aikawa, Nayuta Furukawa, Takayasu Watanabe, Kana Minegishi, Asuka Furukawa, Yoshinobu Eishi, Kenshiro Oshima, Ken Kurokawa, Masahira Hattori, Kazuhiko Nakano, Fumito Maruyama, Ichiro Nakagawa, Takashi Ooshima Chihiro Aikawa, Nayuta Furukawa, Takayasu Watanabe, Kana Minegishi, Asuka Furukawa, Yoshinobu Eishi, Kenshiro Oshima, Ken Kurokawa, Masahira Hattori, Kazuhiko Nakano, Fumito Maruyama, Ichiro Nakagawa, Takashi Ooshima Complete Genome Sequence of the Serotype k Streptococcus mutans Strain LJ23 Complete Genome Sequence of the Serotype k Streptococcus mutans Strain LJ23 Complete Genome Sequence of the Serotype k Streptococcus mutans Strain LJ23 JOURNAL OF BACTERIOLOGY, 194, 10, 2754-2755 JOURNAL OF BACTERIOLOGY, 194, 10, 2754-2755 JOURNAL OF BACTERIOLOGY, 194, 10, 2754-2755 2012/05 英語 研究論文(学術雑誌) 公開
Takashi Nozawa, Nayuta Furukawa, Chihiro Aikawa, Takayasu Watanabe, Bijaya Haobam, Ken Kurokawa, Fumito Maruyama, Ichiro Nakagawa Takashi Nozawa, Nayuta Furukawa, Chihiro Aikawa, Takayasu Watanabe, Bijaya Haobam, Ken Kurokawa, Fumito Maruyama, Ichiro Nakagawa Takashi Nozawa, Nayuta Furukawa, Chihiro Aikawa, Takayasu Watanabe, Bijaya Haobam, Ken Kurokawa, Fumito Maruyama, Ichiro Nakagawa CRISPR Inhibition of Prophage Acquisition in Streptococcus pyogenes CRISPR Inhibition of Prophage Acquisition in Streptococcus pyogenes CRISPR Inhibition of Prophage Acquisition in Streptococcus pyogenes PLOS ONE, 6, 5, e19543 PLOS ONE, 6, 5, e19543 PLOS ONE, 6, 5, e19543 2011/05 英語 研究論文(学術雑誌) 公開
Atsuo Sakurai, Fumito Maruyama, Junko Funao, Takashi Nozawa, Chihiro Aikawa, Nobuo Okahashi, Seikou Shintani, Shigeyuki Hamada, Takashi Ooshima, Ichiro Nakagawa Atsuo Sakurai, Fumito Maruyama, Junko Funao, Takashi Nozawa, Chihiro Aikawa, Nobuo Okahashi, Seikou Shintani, Shigeyuki Hamada, Takashi Ooshima, Ichiro Nakagawa Atsuo Sakurai, Fumito Maruyama, Junko Funao, Takashi Nozawa, Chihiro Aikawa, Nobuo Okahashi, Seikou Shintani, Shigeyuki Hamada, Takashi Ooshima, Ichiro Nakagawa Specific Behavior of Intracellular Streptococcus pyogenes That Has Undergone Autophagic Degradation Is Associated with Bacterial Streptolysin O and Host Small G Proteins Rab5 and Rab7 Specific Behavior of Intracellular Streptococcus pyogenes That Has Undergone Autophagic Degradation Is Associated with Bacterial Streptolysin O and Host Small G Proteins Rab5 and Rab7 Specific Behavior of Intracellular Streptococcus pyogenes That Has Undergone Autophagic Degradation Is Associated with Bacterial Streptolysin O and Host Small G Proteins Rab5 and Rab7 JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 29, 22666-22675 JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 29, 22666-22675 JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 29, 22666-22675 2010/07 英語 研究論文(学術雑誌) 公開
Chihiro Aikawa, Takashi Nozawa, Fumito Maruyama, Kohei Tsumoto, Shigeyuki Hamada, Ichiro Nakagawa Chihiro Aikawa, Takashi Nozawa, Fumito Maruyama, Kohei Tsumoto, Shigeyuki Hamada, Ichiro Nakagawa Chihiro Aikawa, Takashi Nozawa, Fumito Maruyama, Kohei Tsumoto, Shigeyuki Hamada, Ichiro Nakagawa Reactive oxygen species induced by Streptococcus pyogenes invasion trigger apoptotic cell death in infected epithelial cells Reactive oxygen species induced by Streptococcus pyogenes invasion trigger apoptotic cell death in infected epithelial cells Reactive oxygen species induced by Streptococcus pyogenes invasion trigger apoptotic cell death in infected epithelial cells CELLULAR MICROBIOLOGY, 12, 6, 814-830 CELLULAR MICROBIOLOGY, 12, 6, 814-830 CELLULAR MICROBIOLOGY, 12, 6, 814-830 2010/06 英語 研究論文(学術雑誌) 公開
Matsui, H, Sekiya, Y, Aikawa, C, Murayama, S.Y, Takahashi, T, Yoshida, H, Takahashi, T, Tsuchimoto, K, Nakamura, M Matsui, H, Sekiya, Y, Aikawa, C, Murayama, S.Y, Takahashi, T, Yoshida, H, Takahashi, T, Tsuchimoto, K, Nakamura, M Matsui, H, Sekiya, Y, Aikawa, C, Murayama, S.Y, Takahashi, T, Yoshida, H, Takahashi, T, Tsuchimoto, K, Nakamura, M “Candidatus Helicobacter heilmannii” infection in the course of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in human beings and mouse models “Candidatus Helicobacter heilmannii” infection in the course of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in human beings and mouse models “Candidatus Helicobacter heilmannii” infection in the course of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in human beings and mouse models Current Trends in Microbiology, 6, 27-34 Current Trends in Microbiology, 6, 27-34 Current Trends in Microbiology, 6, 27-34 2010/01/01 英語 研究論文(学術雑誌) 公開
Chihiro Aikawa, Fumito Maruyama, Ichiro Nakagawa Chihiro Aikawa, Fumito Maruyama, Ichiro Nakagawa Chihiro Aikawa, Fumito Maruyama, Ichiro Nakagawa The dawning era of comprehensive transcriptome analysis in cellular microbiology The dawning era of comprehensive transcriptome analysis in cellular microbiology The dawning era of comprehensive transcriptome analysis in cellular microbiology FRONTIERS IN MICROBIOLOGY, 1, 118 FRONTIERS IN MICROBIOLOGY, 1, 118 FRONTIERS IN MICROBIOLOGY, 1, 118 2010 英語 公開
Fumito Maruyama, Takashi Nozawa, Chihiro Aikawa, Atsuo Sakurai, Ichiro Nakagawa Fumito Maruyama, Takashi Nozawa, Chihiro Aikawa, Atsuo Sakurai, Ichiro Nakagawa Fumito Maruyama, Takashi Nozawa, Chihiro Aikawa, Atsuo Sakurai, Ichiro Nakagawa Cost effective DNA sequencing and template preparation from bacterial colonies and plasmids Cost effective DNA sequencing and template preparation from bacterial colonies and plasmids Cost effective DNA sequencing and template preparation from bacterial colonies and plasmids JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 107, 4, 471-473 JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 107, 4, 471-473 JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 107, 4, 471-473 2009/04 英語 研究論文(学術雑誌) 公開
Masahiko Nakamura, Shinichi Takahashi, Hidenori Matsui, Somay Yamagata Murayama, Chihiro Aikawa, Yukie Sekiya, Kaori Nishikawa, Tsukasa Matsumoto, Haruki Yamada, Kanji Tsuchimoto Masahiko Nakamura, Shinichi Takahashi, Hidenori Matsui, Somay Yamagata Murayama, Chihiro Aikawa, Yukie Sekiya, Kaori Nishikawa, Tsukasa Matsumoto, Haruki Yamada, Kanji Tsuchimoto Masahiko Nakamura, Shinichi Takahashi, Hidenori Matsui, Somay Yamagata Murayama, Chihiro Aikawa, Yukie Sekiya, Kaori Nishikawa, Tsukasa Matsumoto, Haruki Yamada, Kanji Tsuchimoto Microcirculatory alteration in low-grade gastric mucosa-associated lymphoma by Helicobacter heilmannii infection: Its relation to vascular endothelial growth factor and cyclooxygenase-2 Microcirculatory alteration in low-grade gastric mucosa-associated lymphoma by Helicobacter heilmannii infection: Its relation to vascular endothelial growth factor and cyclooxygenase-2 Microcirculatory alteration in low-grade gastric mucosa-associated lymphoma by Helicobacter heilmannii infection: Its relation to vascular endothelial growth factor and cyclooxygenase-2 JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 23, S157-S160 JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 23, S157-S160 JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 23, S157-S160 2008/12 英語 研究論文(学術雑誌) 公開
Hidenori Matsui, Chihiro Aikawa, Yukie Sekiya, Shinichi Takahashi, Somay Yamagata Murayama, Masahiko Nakamura Hidenori Matsui, Chihiro Aikawa, Yukie Sekiya, Shinichi Takahashi, Somay Yamagata Murayama, Masahiko Nakamura Hidenori Matsui, Chihiro Aikawa, Yukie Sekiya, Shinichi Takahashi, Somay Yamagata Murayama, Masahiko Nakamura Evaluation of antibiotic therapy for eradication of "Candidatus Helicobacter heilmannii" Evaluation of antibiotic therapy for eradication of "Candidatus Helicobacter heilmannii" Evaluation of antibiotic therapy for eradication of "Candidatus Helicobacter heilmannii" ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 52, 8, 2988-2989 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 52, 8, 2988-2989 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 52, 8, 2988-2989 2008/08 英語 研究論文(学術雑誌) 公開

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タイトル言語:
Misc
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Takashi Nozawa, Shunsuke Sano, Atsuko Minowa-Nozawa, Hirotaka Toh, Shintaro Nakajima, Kazunori Murase, Chihiro Aikawa, Ichiro Nakagawa Takashi Nozawa, Shunsuke Sano, Atsuko Minowa-Nozawa, Hirotaka Toh, Shintaro Nakajima, Kazunori Murase, Chihiro Aikawa, Ichiro Nakagawa Takashi Nozawa, Shunsuke Sano, Atsuko Minowa-Nozawa, Hirotaka Toh, Shintaro Nakajima, Kazunori Murase, Chihiro Aikawa, Ichiro Nakagawa TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy. TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy. TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy. Nature communications, 11, 1, 770-770 Nature communications, 11, 1, 770-770 Nature communications, 11, 1, 770-770 2020/02/07 英語 公開
Hirotaka Toh, Ching-Yu Lin, Shintaro Nakajima, Chihiro Aikawa, Takashi Nozawa, Ichiro Nakagawa Hirotaka Toh, Ching-Yu Lin, Shintaro Nakajima, Chihiro Aikawa, Takashi Nozawa, Ichiro Nakagawa Hirotaka Toh, Ching-Yu Lin, Shintaro Nakajima, Chihiro Aikawa, Takashi Nozawa, Ichiro Nakagawa Group A Streptococcus NAD-Glycohydrolase Inhibits Caveolin 1-Mediated Internalization Into Human Epithelial Cells. Group A Streptococcus NAD-Glycohydrolase Inhibits Caveolin 1-Mediated Internalization Into Human Epithelial Cells. Group A Streptococcus NAD-Glycohydrolase Inhibits Caveolin 1-Mediated Internalization Into Human Epithelial Cells. Frontiers in cellular and infection microbiology, 9, 398-398 Frontiers in cellular and infection microbiology, 9, 398-398 Frontiers in cellular and infection microbiology, 9, 398-398 2019 英語 公開
Masahiko Nakamura, Hidenori Matsui, Somay Y. Murayama, Chihiro Aikawa, Yukie Sekiya, Hiroshi Serizawa, Hidekazu Suzuki, Masayuki Suzuki, Shinichi Takahashi, Toshifumi Hibi, Kanji Tsuchimoto Masahiko Nakamura, Hidenori Matsui, Somay Y. Murayama, Chihiro Aikawa, Yukie Sekiya, Hiroshi Serizawa, Hidekazu Suzuki, Masayuki Suzuki, Shinichi Takahashi, Toshifumi Hibi, Kanji Tsuchimoto Masahiko Nakamura, Hidenori Matsui, Somay Y. Murayama, Chihiro Aikawa, Yukie Sekiya, Hiroshi Serizawa, Hidekazu Suzuki, Masayuki Suzuki, Shinichi Takahashi, Toshifumi Hibi, Kanji Tsuchimoto Newly-designed PCR study has revealed one third of MALT lymphoma cases doubly positive to helicobacter heilmannii-like organism and HP in Japan Newly-designed PCR study has revealed one third of MALT lymphoma cases doubly positive to helicobacter heilmannii-like organism and HP in Japan Newly-designed PCR study has revealed one third of MALT lymphoma cases doubly positive to helicobacter heilmannii-like organism and HP in Japan GASTROENTEROLOGY, 132, 4, A289-A289 GASTROENTEROLOGY, 132, 4, A289-A289 GASTROENTEROLOGY, 132, 4, A289-A289 2007/04 英語 研究発表要旨(国際会議) 公開
Sakurai A, Maruyama F, Funao J, Nozawa T, Aikawa C, Okahashi N, Shintani S, Hamada S, Ooshima T, Nakagawa I Sakurai A, Maruyama F, Funao J, Nozawa T, Aikawa C, Okahashi N, Shintani S, Hamada S, Ooshima T, Nakagawa I Sakurai A, Maruyama F, Funao J, Nozawa T, Aikawa C, Okahashi N, Shintani S, Hamada S, Ooshima T, Nakagawa I The specific behavior of intracellular Streptococcus progenies undergone the autophagic degradation is associated with bacterial streptolysin O and host small G proteins Rab5 and Rab7. The specific behavior of intracellular Streptococcus progenies undergone the autophagic degradation is associated with bacterial streptolysin O and host small G proteins Rab5 and Rab7. The specific behavior of intracellular Streptococcus progenies undergone the autophagic degradation is associated with bacterial streptolysin O and host small G proteins Rab5 and Rab7. J Biol Chem, 2010, 285, 29 J Biol Chem, 2010, 285, 29 J Biol Chem, 2010, 285, 29 公開
タイトル言語:
講演・口頭発表等
タイトル タイトル(日本語) タイトル(英語) 会議名 会議名(日本語) 会議名(英語) 主催者 主催者(日本語) 主催者(英語) 開催年月日 記述言語 会議種別 公開
CRISPR/Casシステム:微生物における新規機能とゲノム編集適用例 CRISPR/Casシステム:微生物における新規機能とゲノム編集適用例 日本乳酸菌学会2014年度秋期セミナー・酢酸菌研究会第6回研究集会 合同シンポジウム 日本乳酸菌学会2014年度秋期セミナー・酢酸菌研究会第6回研究集会 合同シンポジウム 2014/12/05 日本語 口頭発表(招待・特別) 公開
タイトル言語:
外部資金:競争的資金 (科学研究費補助金)
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
特別研究員奨励費 代表 細菌感染によるオートファージーと細胞死の生理機能解析 (平成26年度分) 2014/04/01〜2015/03/31
若手研究(B) 代表 感染ステージに応じて宿主生理機能を攪乱するA群レンサ球菌の新規分泌タンパクの同定 (平成26年度分) 2014/04/01〜2015/03/31
基盤研究(C) 代表 Beclin1複合体形成と細菌感染特異的オートファジーにおけるBcl-xLの役割 (平成28年度分) 2016/04/01〜2017/03/31
基盤研究(C) 代表 Beclin1複合体形成と細菌感染特異的オートファジーにおけるBcl-xLの役割 (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(C) 代表 Beclin1複合体形成と細菌感染特異的オートファジーにおけるBcl-xLの役割 (平成30年度分) 2018/04/01〜2019/03/31
基盤研究(C) 代表 細菌感染時の異なるステージを制御するBeclin 1の機能解析 (2019年度分) 2019/04/01〜2020/03/31
部局運営(役職等)
役職名 期間
図書連絡委員会委員 2017/04/01〜2019/03/31