中川 一路

最終更新日時: 2019/06/26 01:28:34

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氏名(漢字/フリガナ/アルファベット表記)
中川 一路/ナカガワ イチロ/Nakagawa, Ichiro
所属部署・職名(部局/所属/講座等/職名)
医学研究科/医学専攻感染・免疫学講座微生物感染症学/教授
学部兼担
部局 所属 講座等 職名
医学部
連絡先住所
種別 住所(日本語) 住所(英語)
職場 京都市左京区吉田近衛町 Yoshida-Konoe-cho, Sakyo-ku ,Kyoto
連絡先電話番号
種別 番号
職場 075-753-4448
所属学会(国内)
学会名(日本語) 学会名(英語)
日本細菌学会 Japanese Society for Microbiology
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
博士(歯学) Doctor of Dental Sciences (DDS) 大阪大学 Osaka University
出身大学院・研究科等
大学名(日本語) 大学名(英語) 研究科名(日本語) 研究科名(英語) 専攻名(日本語) 専攻名(英語) 修了区分
大阪大学 Osaka University 大学院歯学研究科博士課程歯学基礎系専攻 Graduate School of Dental Sciences 修了
出身学校・専攻等
大学名(日本語) 大学名(英語) 学部名(日本語) 学部名(英語) 学科名(日本語) 学科名(英語) 卒業区分
大阪大学 Osaka University 歯学部歯学科 Faculty of Dentistry 卒業
ORCID ID
https://orcid.org/0000-0001-6552-1702
researchmap URL
https://researchmap.jp/read0054817
研究テーマ
(日本語)
全ゲノム解析・マイクロバイオーム解析に基づく細菌の生存戦 略の解明 比較ゲノム解析による病原性細菌の外来性遺伝子獲得機能と 進化機構の解析 細胞内侵入性細菌の認識と排除機構の解析 ゲノム情報を基盤とした新規感染症治療薬の開発
(英語)
Elucidation of survival strategy of bacteria based on whole genome analysis and microbiome analysis Analysis of foreign gene acquisition function and evolutionary mechanism of pathogenic bacteria by comparative genome analysis Analysis of recognition and elimination mechanism of intracellular invasive bacteria Development of novel infectious disease therapeutics based on genomic information
研究概要
(日本語)
 近年、新興・再興感染症の脅威が高まるなか、細菌感染症への予防・治療法としては、いまだ抗菌剤やワクチンの開発に主眼が置かれている。しかし、抗菌剤の使用で目標とする病原体のみを排除することは難しく、不適切な使用は耐性菌の出現・蔓延、さらには正常な細菌叢の撹乱をも引き起こす。また、ワクチンについても、対象とする病原体が限られていることや抗原型が多い菌種では十分に奏功しない例もあり、菌種特異的に奏功する新規薬剤の早急な開発が望まれている。  本研究は、それぞれの細菌種の持つ特定の機能分子と生体分子との相互作用、特にタンパク間の相互作用に対して阻害活性のある低分子化合物やナノ抗体(VHH)を効率的にかつ大規模に解析するシステムを構築し、目標とする細菌種のみに奏功する細菌感染制御が可能な分子標的薬の創薬となる候補物質を探索・選定することを目的としている。これまでの研究で、A群レンサ球菌の鉄獲得輸送系のタンパク質の1つであるShrと、宿主のヘモグロビンの結合を阻害する低分子化合物が、非常に強い増殖阻害活性を示すことを見いだした。この化合物は、既知の抗菌剤とは構造的に全く異なりグラム陰性菌や他属のグラム陽性菌には阻害活性を全く示さないことから、特定の菌種のみをターゲットとした新規薬剤の開発が可能であることが示唆された。  そこで、薬剤耐性化が進む黄色ブドウ球菌や、劇症型感染症が増加しているA群レンサ球菌を対象として、生育に必須な細菌側タンパク質、特に微量金属輸送系や、種間で保存されている機能性分子をターゲットとする。この分子と対応する宿主側分子との結合について、立体構造、物理化学的な性質を詳細に検討し、両者の結合を高感度にかつ効率よくスクリーニングできる系を用いて、新規増殖阻害剤候補を見いだす。候補阻害物質については、各種側鎖の置換体・付加体を作成して、その阻害効果の最も効果的なものを選択する。菌側については、候補遺伝子の変異株や破壊株を用いて、この候補化合物の増殖に対する影響や耐性化を評価する。さらに、マウスを用いた動物実験により、毒性評価や、実際の感染防御能についての評価を行う。  本研究では、社会的な問題となっている多剤耐性菌感染や難治性感染症に対して新規治療法を提案できる可能性が高く、社会的な意義も大きい。また、本研究の方法は、他の菌種に対しても応用が可能であり、将来的な発展も期待できる。
(英語)
Up to today, the emphasis of prevention and treatment for bacterial infectious disease has been on the development of antibiotics and vaccines. However, it is difficult to eliminate a specific pathogen by antibiotics because of their properties, and the excessive administration of antibiotics causes the spread of drug-resistant bacteria and dysbiosis. Therefore, it is especially expected to develop novel drugs with a specific effect against each bacterial pathogen. The purpose of this study is to establish an effective and large-scale screening system for isolating the functional molecules which can effectively inhibit the interaction between bacterial molecules and host molecules, especially for protein-protein interaction. For this purpose, we develop two screening systems, one is the low molecular weight compounds and the other is nanobodies (VHH), and try to isolate validate candidate substances as seeds for molecular targeted drugs that can prevent and control specific bacterial infection. We have already found a low molecular weight compound that showed a strong growth inhibition against Group A Streptococcus (GAS). This compound could inhibit the binding between of Shr, a hemoprotein receptor (iron transporter) of GAS, and the hemoglobin. This compound showed a strong specificity against GAS, and no inhibitory activity against gram-negative bacteria and other gram-positive bacteria. These observations suggest the possibility to develop new drugs targeting specific bacterial species. In this application, we focus on two bacterial species, Staphylococcus aureus (becoming increasingly resistant to antibiotics) and GAS (causing serious invasive infections such as necrotizing fasciitis and streptococcal toxic shock syndrome) to find novel growth inhibitory molecules. We precisely characterize the conformation and physical-chemical properties between target bacterial molecules and host molecules based on the crystal structure, and also establish a screening system that can effectively and high-sensitively analyze the binding state between them. The candidate substances are used as lead compounds for chemical modifications or genetic modifications, and the most effective substance is selected for further analysis. We also construct gene knockout mutants or amino acid substitution mutants of putative binding sites for the candidate substances in target bacteria, and evaluate the effect of these candidates for comparing the growth of these parents strains and mutants and the risk for acquisition of drug resistance. Finally, we evaluate toxicity and protective ability of candidate compounds by animal experiments using mice. We believe that this study might become a milestone providing a new treatment strategy for multidrug-resistant bacterial infection and intractable infectious diseases.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
病原細菌学 Medical Bacteriology
微生物ゲノム Microbial genome
オートファジー Autophagy
創薬 Antimicrobial agents
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Nakajima K, Nozawa T, Minowa-Nozawa A, Toh H, Yamada S, Aikawa C, Nakagawa I. Nakajima K, Nozawa T, Minowa-Nozawa A, Toh H, Yamada S, Aikawa C, Nakagawa I. Nakajima K, Nozawa T, Minowa-Nozawa A, Toh H, Yamada S, Aikawa C, Nakagawa I. RAB30 regulates PI4KB (phosphatidylinositol 4-kinase beta)-dependent autophagy against group A Streptococcus. RAB30 regulates PI4KB (phosphatidylinositol 4-kinase beta)-dependent autophagy against group A Streptococcus. RAB30 regulates PI4KB (phosphatidylinositol 4-kinase beta)-dependent autophagy against group A Streptococcus. Autophagy, 1-12 Autophagy, 1-12 Autophagy, 1-12 2018/10 公開
Arai S, Kim H, Watanabe T, Tohya M, Suzuki E, Ishida-Kuroki K, Maruyama F, Murase K, Nakagawa I, Sekizaki T. Arai S, Kim H, Watanabe T, Tohya M, Suzuki E, Ishida-Kuroki K, Maruyama F, Murase K, Nakagawa I, Sekizaki T. Arai S, Kim H, Watanabe T, Tohya M, Suzuki E, Ishida-Kuroki K, Maruyama F, Murase K, Nakagawa I, Sekizaki T. Assessment of pig saliva as a Streptococcus suis reservoir and potential source of infection on farms by use of a novel quantitative polymerase chain reaction assay Assessment of pig saliva as a Streptococcus suis reservoir and potential source of infection on farms by use of a novel quantitative polymerase chain reaction assay Assessment of pig saliva as a Streptococcus suis reservoir and potential source of infection on farms by use of a novel quantitative polymerase chain reaction assay American Journal of Veterinary Research, 79, 9, 941-948 American Journal of Veterinary Research, 79, 9, 941-948 American Journal of Veterinary Research, 79, 9, 941-948 2018/09 公開
Okada K, Wongboot W, Chantaroj S, Natakuathung W, Roobthaisong A, Kamjumphol W, Maruyama F, Takemura T, Nakagawa I, Ohnishi M, Hamada S. Okada K, Wongboot W, Chantaroj S, Natakuathung W, Roobthaisong A, Kamjumphol W, Maruyama F, Takemura T, Nakagawa I, Ohnishi M, Hamada S. Okada K, Wongboot W, Chantaroj S, Natakuathung W, Roobthaisong A, Kamjumphol W, Maruyama F, Takemura T, Nakagawa I, Ohnishi M, Hamada S. Vibrio cholerae embraces two major evolutionary traits as revealed by targeted gene sequencing Vibrio cholerae embraces two major evolutionary traits as revealed by targeted gene sequencing Vibrio cholerae embraces two major evolutionary traits as revealed by targeted gene sequencing Scientific Reports, 8, 1631 Scientific Reports, 8, 1631 Scientific Reports, 8, 1631 2018/01 公開
Ohara Y, Ozeki Y, Tateishi Y, Mashima T, Arisaka F, Tsunaka Y, Fujiwara Y, Nishiyama A, Yoshida Y, Kitadokoro K, Kobayashi H, Kaneko Y, Nakagawa I, Maekura R, Yamamoto S, Katahira M, Matsumoto S. Ohara Y, Ozeki Y, Tateishi Y, Mashima T, Arisaka F, Tsunaka Y, Fujiwara Y, Nishiyama A, Yoshida Y, Kitadokoro K, Kobayashi H, Kaneko Y, Nakagawa I, Maekura R, Yamamoto S, Katahira M, Matsumoto S. Ohara Y, Ozeki Y, Tateishi Y, Mashima T, Arisaka F, Tsunaka Y, Fujiwara Y, Nishiyama A, Yoshida Y, Kitadokoro K, Kobayashi H, Kaneko Y, Nakagawa I, Maekura R, Yamamoto S, Katahira M, Matsumoto S. Significance of a histone-like protein with its native structure for the diagnosis of asymptomatic tuberculosis. Significance of a histone-like protein with its native structure for the diagnosis of asymptomatic tuberculosis. Significance of a histone-like protein with its native structure for the diagnosis of asymptomatic tuberculosis. PloS ONE, 13, 10, e0204160 PloS ONE, 13, 10, e0204160 PloS ONE, 13, 10, e0204160 2018 公開
Minowa-Nozawa A, Nozawa T, Okamoto-Furuta K, Kohda H, Nakagawa I. Minowa-Nozawa A, Nozawa T, Okamoto-Furuta K, Kohda H, Nakagawa I. Minowa-Nozawa A, Nozawa T, Okamoto-Furuta K, Kohda H, Nakagawa I. Erruatum to: Rab35 GTPase recruits NDP52 to autophagy targets. (EMBO Journal, 2017, 36, 18, 2790-2807) Erruatum to: Rab35 GTPase recruits NDP52 to autophagy targets. (EMBO Journal, 2017, 36, 18, 2790-2807) Erruatum to: Rab35 GTPase recruits NDP52 to autophagy targets. (EMBO Journal, 2017, 36, 18, 2790-2807) EMBO Journal, 36, 22, 3405 EMBO Journal, 36, 22, 3405 EMBO Journal, 36, 22, 3405 2017/11 公開
Hoshino M, Nakakido M, Nagatoishi S, Aikawa C, Nakagawa I, Tsumoto K. Hoshino M, Nakakido M, Nagatoishi S, Aikawa C, Nakagawa I, Tsumoto K. Hoshino M, Nakakido M, Nagatoishi S, Aikawa C, Nakagawa I, Tsumoto K. Biophysical characterization of the interaction between heme and proteins responsible for heme transfer in Streptococcus pyogenes Biophysical characterization of the interaction between heme and proteins responsible for heme transfer in Streptococcus pyogenes Biophysical characterization of the interaction between heme and proteins responsible for heme transfer in Streptococcus pyogenes Biochemical and Biophysical Research Communications, 493, 2, 1109-1114 Biochemical and Biophysical Research Communications, 493, 2, 1109-1114 Biochemical and Biophysical Research Communications, 493, 2, 1109-1114 2017/11 公開
Takemura T, Murase K, Maruyama F, Tran T. L, Ota A, Nakagawa I, Nguyen D. T, Ngo T. C, Nguyen T. H, Tokizawa A, Morita M, Ohnishi M, Nguyen B. M, Yamashiro T. Takemura T, Murase K, Maruyama F, Tran T. L, Ota A, Nakagawa I, Nguyen D. T, Ngo T. C, Nguyen T. H, Tokizawa A, Morita M, Ohnishi M, Nguyen B. M, Yamashiro T. Takemura T, Murase K, Maruyama F, Tran T. L, Ota A, Nakagawa I, Nguyen D. T, Ngo T. C, Nguyen T. H, Tokizawa A, Morita M, Ohnishi M, Nguyen B. M, Yamashiro T. Genetic diversity of environmental Vibrio cholerae O1 strains isolated in Northern Vietnam Genetic diversity of environmental Vibrio cholerae O1 strains isolated in Northern Vietnam Genetic diversity of environmental Vibrio cholerae O1 strains isolated in Northern Vietnam Infection, Genetics and Evolution, 54, 146-151 Infection, Genetics and Evolution, 54, 146-151 Infection, Genetics and Evolution, 54, 146-151 2017/10 公開
Yano H, Iwamoto T, Nishiuchi Y, Nakajima C, Starkova D. A, Mokrousov I, Narvskaya O, Yoshida S, Arikawa K, Nakanishi N, Osaki K, Nakagawa I, Ato M, Suzuki Y, Maruyama F. Yano H, Iwamoto T, Nishiuchi Y, Nakajima C, Starkova D. A, Mokrousov I, Narvskaya O, Yoshida S, Arikawa K, Nakanishi N, Osaki K, Nakagawa I, Ato M, Suzuki Y, Maruyama F. Yano H, Iwamoto T, Nishiuchi Y, Nakajima C, Starkova D. A, Mokrousov I, Narvskaya O, Yoshida S, Arikawa K, Nakanishi N, Osaki K, Nakagawa I, Ato M, Suzuki Y, Maruyama F. Population Structure and Local Adaptation of MAC Lung Disease Agent Mycobacterium avium subsp hominissuis Population Structure and Local Adaptation of MAC Lung Disease Agent Mycobacterium avium subsp hominissuis Population Structure and Local Adaptation of MAC Lung Disease Agent Mycobacterium avium subsp hominissuis Genome Biology and Evolution, 9, 9, 2403-2417 Genome Biology and Evolution, 9, 9, 2403-2417 Genome Biology and Evolution, 9, 9, 2403-2417 2017/09 公開
Minowa-Nozawa A, Nozawa T, Okamoto-Furuta K, Kohda H, Nakagawa I. Minowa-Nozawa A, Nozawa T, Okamoto-Furuta K, Kohda H, Nakagawa I. Minowa-Nozawa A, Nozawa T, Okamoto-Furuta K, Kohda H, Nakagawa I. Rab35 GTPase recruits NPD52 to autophagy targets Rab35 GTPase recruits NPD52 to autophagy targets Rab35 GTPase recruits NPD52 to autophagy targets EMBO Journal, 36, 18, 2790-2807 EMBO Journal, 36, 18, 2790-2807 EMBO Journal, 36, 18, 2790-2807 2017/08 公開
Watanabe T, Shibasaki M, Maruyama F, Sekizaki T, Nakagawa I. Watanabe T, Shibasaki M, Maruyama F, Sekizaki T, Nakagawa I. Watanabe T, Shibasaki M, Maruyama F, Sekizaki T, Nakagawa I. Investigation of potential targets of Porphyromonas CRISPRs among the genomes of Porphyromonas species Investigation of potential targets of Porphyromonas CRISPRs among the genomes of Porphyromonas species Investigation of potential targets of Porphyromonas CRISPRs among the genomes of Porphyromonas species PloS ONE, 12, 8, e0183752 PloS ONE, 12, 8, e0183752 PloS ONE, 12, 8, e0183752 2017/08 公開
Okura M, Nozawa T, Watanabe T, Murase K, Nakagawa I, Takamatsu D, Osaki M, Sekizaki T, Gottschalk M, Hamada S, Maruyama F. Okura M, Nozawa T, Watanabe T, Murase K, Nakagawa I, Takamatsu D, Osaki M, Sekizaki T, Gottschalk M, Hamada S, Maruyama F. Okura M, Nozawa T, Watanabe T, Murase K, Nakagawa I, Takamatsu D, Osaki M, Sekizaki T, Gottschalk M, Hamada S, Maruyama F. A locus encoding variable defence systems against invading DNA identified in Streptococcus suis. A locus encoding variable defence systems against invading DNA identified in Streptococcus suis. A locus encoding variable defence systems against invading DNA identified in Streptococcus suis. Genome Biology and Evolution, 9, 4, 1000-1012 Genome Biology and Evolution, 9, 4, 1000-1012 Genome Biology and Evolution, 9, 4, 1000-1012 2017/04 公開
Nozawa T, Minowa-Nozawa A, Aikawa C, Nakagawa I. Nozawa T, Minowa-Nozawa A, Aikawa C, Nakagawa I. The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes Autophagy, 13, 1, 57-69 Autophagy, 13, 1, 57-69 Autophagy, 13, 1, 57-69 2017/01 公開
Nakajima S, Aikawe C, Nozawa T, Minowa-Nozawa A, Toh H, Nakagawa I. Nakajima S, Aikawe C, Nozawa T, Minowa-Nozawa A, Toh H, Nakagawa I. Nakajima S, Aikawe C, Nozawa T, Minowa-Nozawa A, Toh H, Nakagawa I. Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG PloS ONE, 12, 1, e0170138 PloS ONE, 12, 1, e0170138 PloS ONE, 12, 1, e0170138 2017/01 公開
Roobthaisong A, Aikawa C, Nozawa T, Maruyama F, Nakagawa I. Roobthaisong A, Aikawa C, Nozawa T, Maruyama F, Nakagawa I. Roobthaisong A, Aikawa C, Nozawa T, Maruyama F, Nakagawa I. YvqE and CovRS of Group A Streptococcus Play a Pivotal Role in Viability and Phenotypic Adaptations to Multiple Environmental Stresses. YvqE and CovRS of Group A Streptococcus Play a Pivotal Role in Viability and Phenotypic Adaptations to Multiple Environmental Stresses. YvqE and CovRS of Group A Streptococcus Play a Pivotal Role in Viability and Phenotypic Adaptations to Multiple Environmental Stresses. PloS ONE, 12, 1, e0170612 PloS ONE, 12, 1, e0170612 PloS ONE, 12, 1, e0170612 2017 公開
Nozawa T, Aikawa C, Minowa-Nozawa A,. Nakagawa I. Nozawa T, Aikawa C, Minowa-Nozawa A,. Nakagawa I. Nozawa T, Aikawa C, Minowa-Nozawa A,. Nakagawa I. The intracellular microbial sensor NLRP4 directs Rho-actin signaling to facilitate Group A Streptococcus-containing autophagosome-like vacuole formation The intracellular microbial sensor NLRP4 directs Rho-actin signaling to facilitate Group A Streptococcus-containing autophagosome-like vacuole formation The intracellular microbial sensor NLRP4 directs Rho-actin signaling to facilitate Group A Streptococcus-containing autophagosome-like vacuole formation Autophagy, 13, 11, 1841-1854 Autophagy, 13, 11, 1841-1854 Autophagy, 13, 11, 1841-1854 2017 公開
Kulkarni T, Aikawa C, Nozawa T, Murase K, Maruyama F, Nakagawa I. Kulkarni T, Aikawa C, Nozawa T, Murase K, Maruyama F, Nakagawa I. Kulkarni T, Aikawa C, Nozawa T, Murase K, Maruyama F, Nakagawa I. DNA-based culture-independent analysis detects the presence of group a streptococcus in throat samples from healthy adults in Japan DNA-based culture-independent analysis detects the presence of group a streptococcus in throat samples from healthy adults in Japan DNA-based culture-independent analysis detects the presence of group a streptococcus in throat samples from healthy adults in Japan BMC Microbiology, 16, 237 BMC Microbiology, 16, 237 BMC Microbiology, 16, 237 2016/10 公開
Shiba T, Watanabe T, Kachi H, Koyanagi T, Maruyama N, Murase K, Takeuchi Y, Maruyama F, Izumi Y, Nakagawa I. Shiba T, Watanabe T, Kachi H, Koyanagi T, Maruyama N, Murase K, Takeuchi Y, Maruyama F, Izumi Y, Nakagawa I. Shiba T, Watanabe T, Kachi H, Koyanagi T, Maruyama N, Murase K, Takeuchi Y, Maruyama F, Izumi Y, Nakagawa I. Distinct interacting core taxa in co-occurrence networks enable discrimination of polymicrobial oral diseases with similar symptoms Distinct interacting core taxa in co-occurrence networks enable discrimination of polymicrobial oral diseases with similar symptoms Distinct interacting core taxa in co-occurrence networks enable discrimination of polymicrobial oral diseases with similar symptoms Scientific Reports, 6, 30997 Scientific Reports, 6, 30997 Scientific Reports, 6, 30997 2016/08 公開
Tohya M, Watanabe T, Maruyama F, Arai S, Ota A, Athey T. B. T, Fittipaldi N, Nakagawa I, Sekizaki T. Tohya M, Watanabe T, Maruyama F, Arai S, Ota A, Athey T. B. T, Fittipaldi N, Nakagawa I, Sekizaki T. Tohya M, Watanabe T, Maruyama F, Arai S, Ota A, Athey T. B. T, Fittipaldi N, Nakagawa I, Sekizaki T. Comparative Genome Analyses of Streptococcus suis Isolates from Endocarditis Demonstrate Persistence of Dual Phenotypic Clones Comparative Genome Analyses of Streptococcus suis Isolates from Endocarditis Demonstrate Persistence of Dual Phenotypic Clones Comparative Genome Analyses of Streptococcus suis Isolates from Endocarditis Demonstrate Persistence of Dual Phenotypic Clones PloS ONE, 11, 7, e0159558 PloS ONE, 11, 7, e0159558 PloS ONE, 11, 7, e0159558 2016/07 公開
Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nakagawa I, Kubori T, Nagai H, Nakamaru Y, Katayama I, Colonna M, Arase H. Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nakagawa I, Kubori T, Nagai H, Nakamaru Y, Katayama I, Colonna M, Arase H. Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nakagawa I, Kubori T, Nagai H, Nakamaru Y, Katayama I, Colonna M, Arase H. Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2 Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2 Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2 Nature Microbiology, 1, 16054 Nature Microbiology, 1, 16054 Nature Microbiology, 1, 16054 2016/06 公開
Furusawa T, Iwano H, Higuchi H, Usui M, Maruyama F, Nakagawa I, Yokota H, Tamura Y. Furusawa T, Iwano H, Higuchi H, Usui M, Maruyama F, Nakagawa I, Yokota H, Tamura Y. Furusawa T, Iwano H, Higuchi H, Usui M, Maruyama F, Nakagawa I, Yokota H, Tamura Y. Complete Genome Sequences of Broad-Host-Range Pseudomonas aeruginosa Bacteriophages ΦR18 and ΦS12-1. Complete Genome Sequences of Broad-Host-Range Pseudomonas aeruginosa Bacteriophages ΦR18 and ΦS12-1. Complete Genome Sequences of Broad-Host-Range Pseudomonas aeruginosa Bacteriophages ΦR18 and ΦS12-1. Genome Announcements, 4, 3, e00041-16 Genome Announcements, 4, 3, e00041-16 Genome Announcements, 4, 3, e00041-16 2016/05 公開
Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nakagawa I, Kubori T, Nagai H, Nakamaru Y, Katayama I, Colonna M, Arase H. Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nakagawa I, Kubori T, Nagai H, Nakamaru Y, Katayama I, Colonna M, Arase H. Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nakagawa I, Kubori T, Nagai H, Nakamaru Y, Katayama I, Colonna M, Arase H. Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2. Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2. Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2. Nature Microbiology, 1, 6, 16054 Nature Microbiology, 1, 6, 16054 Nature Microbiology, 1, 6, 16054 2016/04 公開
Paveenkittiporn W, Nozawa, T, Dejsirilert S, Nakagawa I, Hamada S. Paveenkittiporn W, Nozawa, T, Dejsirilert S, Nakagawa I, Hamada S. Paveenkittiporn W, Nozawa, T, Dejsirilert S, Nakagawa I, Hamada S. Prevalent emm types and superantigen gene patterns of group A Streptococcus in Thailand Prevalent emm types and superantigen gene patterns of group A Streptococcus in Thailand Prevalent emm types and superantigen gene patterns of group A Streptococcus in Thailand Epidemiology and Infectione, 144, 4, 864-869 Epidemiology and Infectione, 144, 4, 864-869 Epidemiology and Infection, 144, 4, 864-869 2016/03 公開
Oda S, Nozawa T, Nozawa-Minowa A, Tanaka M, Aikawa C, Harada H, Nakagawa I. Oda S, Nozawa T, Nozawa-Minowa A, Tanaka M, Aikawa C, Harada H, Nakagawa I. Oda S, Nozawa T, Nozawa-Minowa A, Tanaka M, Aikawa C, Harada H, Nakagawa I. Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes PloS ONE, 11, 1, e0147061 PloS ONE, 11, 1, e0147061 PloS ONE, 11, 1, e0147061 2016/01 公開
Maruyama F, Watanabe T, Nakagawa I. Maruyama F, Watanabe T, Nakagawa I. Maruyama F, Watanabe T, Nakagawa I. Streptococcus pyogenes Genomics Streptococcus pyogenes Genomics Streptococcus pyogenes Genomics Streptococcus pyogenes : Basic Biology to Clinical Manifestations Streptococcus pyogenes : Basic Biology to Clinical Manifestations Streptococcus pyogenes : Basic Biology to Clinical Manifestations 2016 公開
Wada T, Maruyama F, Iwamoto T, Maeda S, Yamamoto T, Nakagawa I, Yamamoto S, Ohara N. Wada T, Maruyama F, Iwamoto T, Maeda S, Yamamoto T, Nakagawa I, Yamamoto S, Ohara N. Wada T, Maruyama F, Iwamoto T, Maeda S, Yamamoto T, Nakagawa I, Yamamoto S, Ohara N. Deep sequencing analysis of the heterogeneity of seed and commercial lots of the bacillus Calmette-Guerin (BCG) tuberculosis vaccine substrain Tokyo-172 Deep sequencing analysis of the heterogeneity of seed and commercial lots of the bacillus Calmette-Guerin (BCG) tuberculosis vaccine substrain Tokyo-172 Deep sequencing analysis of the heterogeneity of seed and commercial lots of the bacillus Calmette-Guerin (BCG) tuberculosis vaccine substrain Tokyo-172 Scientific Reports, 5, 17827 Scientific Reports, 5, 17827 Scientific Reports, 5, 17827 2015/12 公開
Okada K, Natakuathung W, Na-Ubol M, Roobthaisong A, Wongboot W, Maruyama F, Nakagawa I, Chantaroj S, Hamada S. Okada K, Natakuathung W, Na-Ubol M, Roobthaisong A, Wongboot W, Maruyama F, Nakagawa I, Chantaroj S, Hamada S. Okada K, Natakuathung W, Na-Ubol M, Roobthaisong A, Wongboot W, Maruyama F, Nakagawa I, Chantaroj S, Hamada S. Characterization of 3 Megabase-Sized Circular Replicons from Vibrio cholerae. Characterization of 3 Megabase-Sized Circular Replicons from Vibrio cholerae. Characterization of 3 Megabase-Sized Circular Replicons from Vibrio cholerae. Emerging Infectious Diseases, 21, 7, 1262-1263 Emerging Infectious Diseases, 21, 7, 1262-1263 Emerging Infectious Diseases, 21, 7, 1262-1263 2015/07 公開
Minegishi K, Watanabe T, Furukawa A, Uchida K, Suzuki Y, Akashi T, Maruyama F, Nakagawa I, Eishi Y. Minegishi K, Watanabe T, Furukawa A, Uchida K, Suzuki Y, Akashi T, Maruyama F, Nakagawa I, Eishi Y. Minegishi K, Watanabe T, Furukawa A, Uchida K, Suzuki Y, Akashi T, Maruyama F, Nakagawa I, Eishi Y. Genetic profiles of Propionibacterium acnes and identification of a unique transposon with novel insertion sequences in sarcoid and non-sarcoid isolates Genetic profiles of Propionibacterium acnes and identification of a unique transposon with novel insertion sequences in sarcoid and non-sarcoid isolates Genetic profiles of Propionibacterium acnes and identification of a unique transposon with novel insertion sequences in sarcoid and non-sarcoid isolates Scientific Reports, 5, 9832 Scientific Reports, 5, 9832 Scientific Reports, 5, 9832 2015/05 公開
Endo A, Watanabe T, Ogata N, Nozawa T, Aikawa C, Arakawa S, Maruyama F, Izumi Y, Nakagawa I. Endo A, Watanabe T, Ogata N, Nozawa T, Aikawa C, Arakawa S, Maruyama F, Izumi Y, Nakagawa I. Endo A, Watanabe T, Ogata N, Nozawa T, Aikawa C, Arakawa S, Maruyama F, Izumi Y, Nakagawa I. Comparative genome analysis and identification of competitive and cooperative interactions in a polymicrobial disease Comparative genome analysis and identification of competitive and cooperative interactions in a polymicrobial disease Comparative genome analysis and identification of competitive and cooperative interactions in a polymicrobial disease ISME Journal, 9, 3, 629-642 ISME Journal, 9, 3, 629-642 ISME Journal, 9, 3, 629-642 2015/03 公開
Nozawa T, Nakagawa I. Nozawa T, Nakagawa I. Nozawa T, Nakagawa I. Rab Proteins in Autophagy: Streptococcus Model Rab Proteins in Autophagy: Streptococcus Model Rab Proteins in Autophagy: Streptococcus Model Autophagy, Infection, and the Immune Response, 159-169 Autophagy, Infection, and the Immune Response, 159-169 Autophagy, Infection, and the Immune Response, 159-169 2015/02 公開
Hamada S, Kawabata S, Nakagawa I. Hamada S, Kawabata S, Nakagawa I. Hamada S, Kawabata S, Nakagawa I. Molecular and genomic characterization of pathogenic traits of group A Streptococcus pyogenes. Molecular and genomic characterization of pathogenic traits of group A Streptococcus pyogenes. Molecular and genomic characterization of pathogenic traits of group A Streptococcus pyogenes. Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 91, 10, 539-559 Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 91, 10, 539-559 Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 91, 10, 539-559 2015 公開
Haobam B, Nozawa T, Minowa-Nozawa A, Tanaka M, Oda S, Watanabe T, Aikawa C, Maruyama F, Nakagawa I. Haobam B, Nozawa T, Minowa-Nozawa A, Tanaka M, Oda S, Watanabe T, Aikawa C, Maruyama F, Nakagawa I. Haobam B, Nozawa T, Minowa-Nozawa A, Tanaka M, Oda S, Watanabe T, Aikawa C, Maruyama F, Nakagawa I. Rab17-mediated recycling endosomes contribute to autophagosome formation in response to Group A Streptococcus invasion Rab17-mediated recycling endosomes contribute to autophagosome formation in response to Group A Streptococcus invasion Rab17-mediated recycling endosomes contribute to autophagosome formation in response to Group A Streptococcus invasion Cellular Microbiology, 16, 12, 1806-1821 Cellular Microbiology, 16, 12, 1806-1821 Cellular Microbiology, 16, 12, 1806-1821 2014/12 公開
Kawabe A, Nakagawa I, Kanno Z, Tsutsumi Y, Hanawa T, Ono T. Kawabe A, Nakagawa I, Kanno Z, Tsutsumi Y, Hanawa T, Ono T. Kawabe A, Nakagawa I, Kanno Z, Tsutsumi Y, Hanawa T, Ono T. Evaluation of biofilm formation in the presence of saliva on poly(ethylene-glycol)-deposited titanium Evaluation of biofilm formation in the presence of saliva on poly(ethylene-glycol)-deposited titanium Evaluation of biofilm formation in the presence of saliva on poly(ethylene-glycol)-deposited titanium Dental Materials Journal, 33, 5, 638-647 Dental Materials Journal, 33, 5, 638-647 Dental Materials Journal, 33, 5, 638-647 2014/10 公開
Maruyama N, Maruyama F, Takeuchi Y, Aikawa C, Izumi Y, Nakagawa I. Maruyama N, Maruyama F, Takeuchi Y, Aikawa C, Izumi Y, Nakagawa I. Maruyama N, Maruyama F, Takeuchi Y, Aikawa C, Izumi Y, Nakagawa I. Intraindividual variation in core microbiota in peri-implantitis and periodontitis. Intraindividual variation in core microbiota in peri-implantitis and periodontitis. Intraindividual variation in core microbiota in peri-implantitis and periodontitis. Scientific Reports, 4, 6602 Scientific Reports, 4, 6602 Scientific Reports, 4, 6602 2014/10 公開
Nakakido M, Aikawa C, Nakagawa I, Tsumoto K. Nakakido M, Aikawa C, Nakagawa I, Tsumoto K. Nakakido M, Aikawa C, Nakagawa I, Tsumoto K. The staphylococcal elastin-binding protein regulates zinc-dependent growth/biofilm formation The staphylococcal elastin-binding protein regulates zinc-dependent growth/biofilm formation The staphylococcal elastin-binding protein regulates zinc-dependent growth/biofilm formation Journal of Biochemistry, 156, 3, 155-162 Journal of Biochemistry, 156, 3, 155-162 Journal of Biochemistry, 156, 3, 155-162 2014/09 公開
Okada K, Na-Ubol M, Natakuathung W, Roobthaisong A, Maruyama F, Nakagawa I, Chantaroj S, Hamada S. Okada K, Na-Ubol M, Natakuathung W, Roobthaisong A, Maruyama F, Nakagawa I, Chantaroj S, Hamada S. Okada K, Na-Ubol M, Natakuathung W, Roobthaisong A, Maruyama F, Nakagawa I, Chantaroj S, Hamada S. Comparative Genomic Characterization of a Thailand-Myanmar Isolate, MS6, of Vibrio cholerae O1 El Tor, Which Is Phylogenetically Related to a "US Gulf Coast" Clone Comparative Genomic Characterization of a Thailand-Myanmar Isolate, MS6, of Vibrio cholerae O1 El Tor, Which Is Phylogenetically Related to a "US Gulf Coast" Clone Comparative Genomic Characterization of a Thailand-Myanmar Isolate, MS6, of Vibrio cholerae O1 El Tor, Which Is Phylogenetically Related to a "US Gulf Coast" Clone PloS ONE, 9, 6, e98120 PloS ONE, 9, 6, e98120 PloS ONE, 9, 6, e98120 2014/06 公開
Okura M, lachance C, Osaki M, Sekizaki T, Maruyama F, Nozawa T, Nakagawa I, Hamada S, Rossignol C, Gottschalk M, Takamatsu D. Okura M, lachance C, Osaki M, Sekizaki T, Maruyama F, Nozawa T, Nakagawa I, Hamada S, Rossignol C, Gottschalk M, Takamatsu D. Okura M, lachance C, Osaki M, Sekizaki T, Maruyama F, Nozawa T, Nakagawa I, Hamada S, Rossignol C, Gottschalk M, Takamatsu D. Development of a Two-Step Multiplex PCR Assay for Typing of Capsular Polysaccharide Synthesis Gene Clusters of Streptococcus suis Development of a Two-Step Multiplex PCR Assay for Typing of Capsular Polysaccharide Synthesis Gene Clusters of Streptococcus suis Development of a Two-Step Multiplex PCR Assay for Typing of Capsular Polysaccharide Synthesis Gene Clusters of Streptococcus suis Journal of Clinical Microbiology, 52, 5, 1714-1719 Journal of Clinical Microbiology, 52, 5, 1714-1719 Journal of Clinical Microbiology, 52, 5, 1714-1719 2014/05 公開
Goda A, Maruyama F, Michi Y, Nakagawa I, Harada K. Goda A, Maruyama F, Michi Y, Nakagawa I, Harada K. Goda A, Maruyama F, Michi Y, Nakagawa I, Harada K. Analysis of the factors affecting the formation of the microbiome associated with chronic osteomyelitis of the jaw Analysis of the factors affecting the formation of the microbiome associated with chronic osteomyelitis of the jaw Analysis of the factors affecting the formation of the microbiome associated with chronic osteomyelitis of the jaw Clinical Microbiology and Infection, 20, 5, O319-O317 Clinical Microbiology and Infection, 20, 5, O319-O317 Clinical Microbiology and Infection, 20, 5, O319-O317 2014/05 公開
Ohnishi N, Maruyama F, Ogawa H, Kachi H, Yamada S, Fujikura D, Nakagawa I, Hang'ombe MB, Thomas Y, Mweene AS, Higashi H. Ohnishi N, Maruyama F, Ogawa H, Kachi H, Yamada S, Fujikura D, Nakagawa I, Hang'ombe MB, Thomas Y, Mweene AS, Higashi H. Ohnishi N, Maruyama F, Ogawa H, Kachi H, Yamada S, Fujikura D, Nakagawa I, Hang'ombe MB, Thomas Y, Mweene AS, Higashi H. Genome Sequence of a Bacillus anthracis Outbreak Strain from Zambia, 2011. Genome Sequence of a Bacillus anthracis Outbreak Strain from Zambia, 2011. Genome Sequence of a Bacillus anthracis Outbreak Strain from Zambia, 2011. Genome Announcements, 2, 2, e00116-14 Genome Announcements, 2, 2, e00116-14 Genome Announcements, 2, 2, e00116-14 2014/03 公開
Nakagawa I. Nakagawa I. Nakagawa I. Streptococcus pyogenes Escapes from Autophagy Streptococcus pyogenes Escapes from Autophagy Streptococcus pyogenes Escapes from Autophagy Cell Host and Microbe, 14, 6, 604-606 Cell Host and Microbe, 14, 6, 604-606 Cell Host and Microbe, 14, 6, 604-606 2013/12 公開
Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, Arimoto H. Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, Arimoto H. Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, Arimoto H. Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria. Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria. Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria. Molecular Cell, 52, 6, 794-804 Molecular Cell, 52, 6, 794-804 Molecular Cell, 52, 6, 794-804 2013/12 公開
Okura M, Takamatsu D, Maruyama F, Nozawa T, Nakagawa I, Osaki M, Sekizaki T, Gottschalk M, Kumagai Y, Hamada S. Okura M, Takamatsu D, Maruyama F, Nozawa T, Nakagawa I, Osaki M, Sekizaki T, Gottschalk M, Kumagai Y, Hamada S. Okura M, Takamatsu D, Maruyama F, Nozawa T, Nakagawa I, Osaki M, Sekizaki T, Gottschalk M, Kumagai Y, Hamada S. Genetic Analysis of Capsular Polysaccharide Synthesis Gene Clusters from All Serotypes of Streptococcus suis: Potential Mechanisms for Generation of Capsular Variation Genetic Analysis of Capsular Polysaccharide Synthesis Gene Clusters from All Serotypes of Streptococcus suis: Potential Mechanisms for Generation of Capsular Variation Genetic Analysis of Capsular Polysaccharide Synthesis Gene Clusters from All Serotypes of Streptococcus suis: Potential Mechanisms for Generation of Capsular Variation Applied and Environmental Microbiology, 79, 8, 2796-2806 Applied and Environmental Microbiology, 79, 8, 2796-2806 Applied and Environmental Microbiology, 79, 8, 2796-2806 2013/04 公開
Minegishi K, Aikawa C, Furukawa A, Watanabe T, Nakano T, Ogura Y, Ohtsubo Y, Kurokawa K, Hayashi T, Maruyama F, Nakagawa I, Eishi Y. Minegishi K, Aikawa C, Furukawa A, Watanabe T, Nakano T, Ogura Y, Ohtsubo Y, Kurokawa K, Hayashi T, Maruyama F, Nakagawa I, Eishi Y. Minegishi K, Aikawa C, Furukawa A, Watanabe T, Nakano T, Ogura Y, Ohtsubo Y, Kurokawa K, Hayashi T, Maruyama F, Nakagawa I, Eishi Y. Complete Genome Sequence of a Propionibacterium acnes Isolate from a Sarcoidosis Patient. Complete Genome Sequence of a Propionibacterium acnes Isolate from a Sarcoidosis Patient. Complete Genome Sequence of a Propionibacterium acnes Isolate from a Sarcoidosis Patient. Genome Announcements, 1, 1, e00016-12 Genome Announcements, 1, 1, e00016-12 Genome Announcements, 1, 1, e00016-12 2013/01 公開
Nakano K, Nakagawa I, Alaluusua S, Ooshima T. Nakano K, Nakagawa I, Alaluusua S, Ooshima T. Nakano K, Nakagawa I, Alaluusua S, Ooshima T. Molecular typing of Streptococcus mutans Molecular typing of Streptococcus mutans Molecular typing of Streptococcus mutans Molecular Typing in Bacterial Infections, 127-147 Molecular Typing in Bacterial Infections, 127-147 Molecular Typing in Bacterial Infections, 127-147 2013/01 公開
Watanabe T, Nozawa T, Aikawa C, Amano A, Maruyama F, Nakagawa I. Watanabe T, Nozawa T, Aikawa C, Amano A, Maruyama F, Nakagawa I. Watanabe T, Nozawa T, Aikawa C, Amano A, Maruyama F, Nakagawa I. CRISPR Regulation of Intraspecies Diversification by Limiting IS Transposition and Intercellular Recombination CRISPR Regulation of Intraspecies Diversification by Limiting IS Transposition and Intercellular Recombination CRISPR Regulation of Intraspecies Diversification by Limiting IS Transposition and Intercellular Recombination Genome Biology and Evolution, 5, 6, 1099-1114 Genome Biology and Evolution, 5, 6, 1099-1114 Genome Biology and Evolution, 5, 6, 1099-1114 2013 公開
Ogawa M, Sugita S, Shimizu N, Watanabe K, Nakagawa I, Mochizuki M. Ogawa M, Sugita S, Shimizu N, Watanabe K, Nakagawa I, Mochizuki M. Ogawa M, Sugita S, Shimizu N, Watanabe K, Nakagawa I, Mochizuki M. Broad-range real-time PCR assay for detection of bacterial DNA in ocular samples from infectious endophthalmitis. Broad-range real-time PCR assay for detection of bacterial DNA in ocular samples from infectious endophthalmitis. Broad-range real-time PCR assay for detection of bacterial DNA in ocular samples from infectious endophthalmitis. Japanese Journal of Ophthalmology, 56, 6, 529-535 Japanese Journal of Ophthalmology, 56, 6, 529-535 Japanese Journal of Ophthalmology, 56, 6, 529-535 2012/11 公開
Nozawa T, Aikawa C, Goda A, Maruyama F, Hamada S, Nakagawa I. Nozawa T, Aikawa C, Goda A, Maruyama F, Hamada S, Nakagawa I. Nozawa T, Aikawa C, Goda A, Maruyama F, Hamada S, Nakagawa I. The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection. The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection. The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection. Cellular Microbiology, 14, 8, 1149-1165 Cellular Microbiology, 14, 8, 1149-1165 Cellular Microbiology, 14, 8, 1149-1165 2012/08 公開
Aikawa C, Furukawa N, Watanabe T, Minegishi K, Furukawa A, Eishi Y, Oshima K, Kurokawa K, Hattori M, Nakano K, Maruyama F, Nakagawa I, Ooshima T. Aikawa C, Furukawa N, Watanabe T, Minegishi K, Furukawa A, Eishi Y, Oshima K, Kurokawa K, Hattori M, Nakano K, Maruyama F, Nakagawa I, Ooshima T. Aikawa C, Furukawa N, Watanabe T, Minegishi K, Furukawa A, Eishi Y, Oshima K, Kurokawa K, Hattori M, Nakano K, Maruyama F, Nakagawa I, Ooshima T. Complete genome sequence of the serotype k Streptococcus mutans strain LJ23. Complete genome sequence of the serotype k Streptococcus mutans strain LJ23. Complete genome sequence of the serotype k Streptococcus mutans strain LJ23. Journal of Bacteriology, 194, 10, 2754-2755 Journal of Bacteriology, 194, 10, 2754-2755 Journal of Bacteriology, 194, 10, 2754-2755 2012/05 公開
Aoki A, Shibata Y, Okano S, Maruyama F, Amano A, Nakagawa I, Abiko Y. Aoki A, Shibata Y, Okano S, Maruyama F, Amano A, Nakagawa I, Abiko Y. Aoki A, Shibata Y, Okano S, Maruyama F, Amano A, Nakagawa I, Abiko Y. Transition metal ions induce carnosinase activity in PepD-homologous protein from Porphyromonas gingivalis. Transition metal ions induce carnosinase activity in PepD-homologous protein from Porphyromonas gingivalis. Transition metal ions induce carnosinase activity in PepD-homologous protein from Porphyromonas gingivalis. Microbial Pathogenesis, 52, 1, 17-24 Microbial Pathogenesis, 52, 1, 17-24 Microbial Pathogenesis, 52, 1, 17-24 2012/01 公開
Okada K, Roobthaisong A, Nakagawa I, Hamada S, Chantaroj S. Okada K, Roobthaisong A, Nakagawa I, Hamada S, Chantaroj S. Okada K, Roobthaisong A, Nakagawa I, Hamada S, Chantaroj S. Genotypic and PFGE/MLVA analyses of Vibrio cholerae O1: geographical spread and temporal changes during the 2007-2010 cholera outbreaks in Thailand. Genotypic and PFGE/MLVA analyses of Vibrio cholerae O1: geographical spread and temporal changes during the 2007-2010 cholera outbreaks in Thailand. Genotypic and PFGE/MLVA analyses of Vibrio cholerae O1: geographical spread and temporal changes during the 2007-2010 cholera outbreaks in Thailand. PloS ONE, 7, 1, e30863 PloS ONE, 7, 1, e30863 PloS ONE, 7, 1, e30863 2012 公開
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Nagahama M, Itohayashi Y, Hara H, Higashihara M, Fukatani Y, Takagishi T, Oda M, Kobayashi K, Nakagawa I, Sakurai J. Nagahama M, Itohayashi Y, Hara H, Higashihara M, Fukatani Y, Takagishi T, Oda M, Kobayashi K, Nakagawa I, Sakurai J. Nagahama M, Itohayashi Y, Hara H, Higashihara M, Fukatani Y, Takagishi T, Oda M, Kobayashi K, Nakagawa I, Sakurai J. Cellular vacuolation induced by Clostridium perfringens epsilon-toxin. Cellular vacuolation induced by Clostridium perfringens epsilon-toxin. Cellular vacuolation induced by Clostridium perfringens epsilon-toxin. FEBS Journal, 278, 18, 3395-3407 FEBS Journal, 278, 18, 3395-3407 FEBS Journal, 278, 18, 3395-3407 2011/09 公開
Watanabe T, Maruyama F, Nozawa T, Aoki A, Okano S, Shibata Y, Oshima K, Kurokawa K, Hattori M, Nakagawa I, Abiko Y. Watanabe T, Maruyama F, Nozawa T, Aoki A, Okano S, Shibata Y, Oshima K, Kurokawa K, Hattori M, Nakagawa I, Abiko Y. Watanabe T, Maruyama F, Nozawa T, Aoki A, Okano S, Shibata Y, Oshima K, Kurokawa K, Hattori M, Nakagawa I, Abiko Y. Complete genome sequence of the bacterium Porphyromonas gingivalis TDC60, which causes periodontal disease. Complete genome sequence of the bacterium Porphyromonas gingivalis TDC60, which causes periodontal disease. Complete genome sequence of the bacterium Porphyromonas gingivalis TDC60, which causes periodontal disease. Journal of Bacteriology, 193, 16, 4259-4260 Journal of Bacteriology, 193, 16, 4259-4260 Journal of Bacteriology, 193, 16, 4259-4260 2011/08 公開
Yamato K, Egawa N, Endo S, Ui-Tei K, Yamada T, Saigo K, Hyodo I, Kiyono T, Nakagawa I. Yamato K, Egawa N, Endo S, Ui-Tei K, Yamada T, Saigo K, Hyodo I, Kiyono T, Nakagawa I. Yamato K, Egawa N, Endo S, Ui-Tei K, Yamada T, Saigo K, Hyodo I, Kiyono T, Nakagawa I. Enhanced specificity of HPV16 E6E7 siRNA by RNA-DNA chimera modification Enhanced specificity of HPV16 E6E7 siRNA by RNA-DNA chimera modification Enhanced specificity of HPV16 E6E7 siRNA by RNA-DNA chimera modification Cancer Gene Therapy, 18, 8, 587-597 Cancer Gene Therapy, 18, 8, 587-597 Cancer Gene Therapy, 18, 8, 587-597 2011/08 公開
Nozawa T, Furukawa N, Aikawa C, Watanabe T, Haobam B, Kurokawa K, Maruyama F, Nakagawa I. Nozawa T, Furukawa N, Aikawa C, Watanabe T, Haobam B, Kurokawa K, Maruyama F, Nakagawa I. Nozawa T, Furukawa N, Aikawa C, Watanabe T, Haobam B, Kurokawa K, Maruyama F, Nakagawa I. CRISPR inhibition of prophage acquisition in Streptococcus pyogenes. CRISPR inhibition of prophage acquisition in Streptococcus pyogenes. CRISPR inhibition of prophage acquisition in Streptococcus pyogenes. PloS ONE, 6, 5, e19543 PloS ONE, 6, 5, e19543 PloS ONE, 6, 5, e19543 2011/05 公開
Endo S, Yamato K, Hirai S, Moriwaki T, Fukuda K, Suzuki H, Abei M, Nakagawa I, Hyodo I. Endo S, Yamato K, Hirai S, Moriwaki T, Fukuda K, Suzuki H, Abei M, Nakagawa I, Hyodo I. Endo S, Yamato K, Hirai S, Moriwaki T, Fukuda K, Suzuki H, Abei M, Nakagawa I, Hyodo I. Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells. Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells. Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells. Cancer Science, 102, 3, 605-613 Cancer Science, 102, 3, 605-613 Cancer Science, 102, 3, 605-613 2011/03 公開
Izumo T, Izumi F, Nakagawa I, Kitagawa Y, Shibata H, Kiso Y. Izumo T, Izumi F, Nakagawa I, Kitagawa Y, Shibata H, Kiso Y. Izumo T, Izumi F, Nakagawa I, Kitagawa Y, Shibata H, Kiso Y. Influence of Lactobacillus pentosus S-PT84 Ingestion on the Mucosal Immunity of Healthy and Salmonella Typhimurium-Infected Mice. Influence of Lactobacillus pentosus S-PT84 Ingestion on the Mucosal Immunity of Healthy and Salmonella Typhimurium-Infected Mice. Influence of Lactobacillus pentosus S-PT84 Ingestion on the Mucosal Immunity of Healthy and Salmonella Typhimurium-Infected Mice. Bioscience and Microflora, 30, 2, 27-35 Bioscience and Microflora, 30, 2, 27-35 Bioscience and Microflora, 30, 2, 27-35 2011 公開
Aikawa C, Maruyama F, Nakagawa I. Aikawa C, Maruyama F, Nakagawa I. Aikawa C, Maruyama F, Nakagawa I. The dawning era of comprehensive transcriptome analysis in cellular microbiology. The dawning era of comprehensive transcriptome analysis in cellular microbiology. The dawning era of comprehensive transcriptome analysis in cellular microbiology. Frontiers in Microbiology, 1, 118 Frontiers in Microbiology, 1, 118 Frontiers in Microbiology, 1, 118 2010/11 公開
Sakurai A, Maruyama F, Funao J, Nozawa T, Aikawa C, Okahashi N, Shintani S, Hamada S, Ooshima T, Nakagawa I. Sakurai A, Maruyama F, Funao J, Nozawa T, Aikawa C, Okahashi N, Shintani S, Hamada S, Ooshima T, Nakagawa I. Sakurai A, Maruyama F, Funao J, Nozawa T, Aikawa C, Okahashi N, Shintani S, Hamada S, Ooshima T, Nakagawa I. Specific behavior of intracellular Streptococcus pyogenes that has undergone autophagic degradation is associated with bacterial streptolysin O and host small G proteins Rab5 and Rab7. Specific behavior of intracellular Streptococcus pyogenes that has undergone autophagic degradation is associated with bacterial streptolysin O and host small G proteins Rab5 and Rab7. Specific behavior of intracellular Streptococcus pyogenes that has undergone autophagic degradation is associated with bacterial streptolysin O and host small G proteins Rab5 and Rab7. Journal of Biological Chemistry, 285, 29, 22666-22675 Journal of Biological Chemistry, 285, 29, 22666-22675 Journal of Biological Chemistry, 285, 29, 22666-22675 2010/07 公開
Aikawa C, Nozawa T, Maruyama F, Tsumoto K, Hamada S, Nakagawa I. Aikawa C, Nozawa T, Maruyama F, Tsumoto K, Hamada S, Nakagawa I. Aikawa C, Nozawa T, Maruyama F, Tsumoto K, Hamada S, Nakagawa I. Reactive oxygen species induced by Streptococcus pyogenes invasion trigger apoptotic cell death in infected epithelial cells. Reactive oxygen species induced by Streptococcus pyogenes invasion trigger apoptotic cell death in infected epithelial cells. Reactive oxygen species induced by Streptococcus pyogenes invasion trigger apoptotic cell death in infected epithelial cells. Cellular Microbiology, 12, 6, 814-830 Cellular Microbiology, 12, 6, 814-830 Cellular Microbiology, 12, 6, 814-830 2010/06 公開
Yamaguchi H, Nakagawa I, Yamamoto A, Amano A, Noda T, Yoshimori T. Yamaguchi H, Nakagawa I, Yamamoto A, Amano A, Noda T, Yoshimori T. Yamaguchi H, Nakagawa I, Yamamoto A, Amano A, Noda T, Yoshimori T. An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7. An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7. An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7. PLoS Pathogens, 5, 11, e1000670 PLoS Pathogens, 5, 11, e1000670 PLoS Pathogens, 5, 11, e1000670 2009/11 公開
Yoshikawa Y, Ogawa M, Hain T, Yoshida M, Fukumatsu M, Kim M, Mimuro H, Nakagawa I, Yanagawa T, Ishii T, Kakizuka A, Sztul E, Chakraborty T, Sasakawa C. Yoshikawa Y, Ogawa M, Hain T, Yoshida M, Fukumatsu M, Kim M, Mimuro H, Nakagawa I, Yanagawa T, Ishii T, Kakizuka A, Sztul E, Chakraborty T, Sasakawa C. Yoshikawa Y, Ogawa M, Hain T, Yoshida M, Fukumatsu M, Kim M, Mimuro H, Nakagawa I, Yanagawa T, Ishii T, Kakizuka A, Sztul E, Chakraborty T, Sasakawa C. Listeria monocytogenes ActA-mediated escape from autophagic recognition. Listeria monocytogenes ActA-mediated escape from autophagic recognition. Listeria monocytogenes ActA-mediated escape from autophagic recognition. Nature Cell Biology, 11, 10, 1233-1240 Nature Cell Biology, 11, 10, 1233-1240 Nature Cell Biology, 11, 10, 1233-1240 2009/10 公開
Maruyama F, Kobata M, Kurokawa K, Nishida K, Sakurai A, Nakano K, Nomura R, Kawabata S, Ooshima T, Nakai K, Hattori M, Hamada S, Nakagawa I. Maruyama F, Kobata M, Kurokawa K, Nishida K, Sakurai A, Nakano K, Nomura R, Kawabata S, Ooshima T, Nakai K, Hattori M, Hamada S, Nakagawa I. Maruyama F, Kobata M, Kurokawa K, Nishida K, Sakurai A, Nakano K, Nomura R, Kawabata S, Ooshima T, Nakai K, Hattori M, Hamada S, Nakagawa I. Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content. Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content. Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content. BMC Genomics, 10, 358 BMC Genomics, 10, 358 BMC Genomics, 10, 358 2009/08 公開
Nakagawa I. Nakagawa I. Nakagawa I. Bacterial genome analysis and its applications for infectious diseases. Bacterial genome analysis and its applications for infectious diseases. Bacterial genome analysis and its applications for infectious diseases. Nihon rinsho. Japanese journal of clinical medicine, 67, 6, 1120-1133 Nihon rinsho. Japanese journal of clinical medicine, 67, 6, 1120-1133 Nihon rinsho. Japanese journal of clinical medicine, 67, 6, 1120-1133 2009/06 公開
Nakagawa I. Nakagawa I. Nakagawa I. Bacterial infection and autophagy. Bacterial infection and autophagy. Bacterial infection and autophagy. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 8 Suppl, 1002-1008 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 8 Suppl, 1002-1008 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 8 Suppl, 1002-1008 2009/06 公開
Maruyama F, Nozawa T, Aikawa C, Sakurai A, Nakagawa I. Maruyama F, Nozawa T, Aikawa C, Sakurai A, Nakagawa I. Maruyama F, Nozawa T, Aikawa C, Sakurai A, Nakagawa I. Cost effective DNA sequencing and template preparation from bacterial colonies and plasmids. Cost effective DNA sequencing and template preparation from bacterial colonies and plasmids. Cost effective DNA sequencing and template preparation from bacterial colonies and plasmids. Journal of Bioscience and Bioengineering, 107, 4, 471-473 Journal of Bioscience and Bioengineering, 107, 4, 471-473 Journal of Bioscience and Bioengineering, 107, 4, 471-473 2009/04 公開
Ogawa M, Nakagawa I, Yoshikawa Y, Hain T, Chakraborty T, Sasakawa C. Ogawa M, Nakagawa I, Yoshikawa Y, Hain T, Chakraborty T, Sasakawa C. Ogawa M, Nakagawa I, Yoshikawa Y, Hain T, Chakraborty T, Sasakawa C. Chapter 22 Streptococcus-, Shigella-, and Listeria-induced autophagy. Chapter 22 Streptococcus-, Shigella-, and Listeria-induced autophagy. Chapter 22 Streptococcus-, Shigella-, and Listeria-induced autophagy. Methods in Enzymology, 452, 363-381 Methods in Enzymology, 452, 363-381 Methods in Enzymology, 452, 363-381 2009 公開
Lapirattanakul J, Nakano K, Nomura R, Hamada S, Nakagawa I, Ooshima T. Lapirattanakul J, Nakano K, Nomura R, Hamada S, Nakagawa I, Ooshima T. Lapirattanakul J, Nakano K, Nomura R, Hamada S, Nakagawa I, Ooshima T. Demonstration of mother-to-child transmission of Streptococcus mutans using multilocus sequence typing Demonstration of mother-to-child transmission of Streptococcus mutans using multilocus sequence typing Demonstration of mother-to-child transmission of Streptococcus mutans using multilocus sequence typing Caries Research, 42, 6, 466-474 Caries Research, 42, 6, 466-474 Caries Research, 42, 6, 466-474 2008/11 公開
Ishimaru M, Yamada M, Nakagawa I, Sugano S. Ishimaru M, Yamada M, Nakagawa I, Sugano S. Ishimaru M, Yamada M, Nakagawa I, Sugano S. Analysis of volatile metabolites from cultured bacteria by gas chromatography/atmospheric pressure chemical ionization-mass spectrometry. Analysis of volatile metabolites from cultured bacteria by gas chromatography/atmospheric pressure chemical ionization-mass spectrometry. Analysis of volatile metabolites from cultured bacteria by gas chromatography/atmospheric pressure chemical ionization-mass spectrometry. Journal of Breath Research, 2, 3, 037021 Journal of Breath Research, 2, 3, 037021 Journal of Breath Research, 2, 3, 037021 2008/09 公開
Sakurai A, Okahashi N, Maruyama F, Ooshima T, Hamada S, Nakagawa I. Sakurai A, Okahashi N, Maruyama F, Ooshima T, Hamada S, Nakagawa I. Sakurai A, Okahashi N, Maruyama F, Ooshima T, Hamada S, Nakagawa I. Streptococcus pyogenes degrades extracellular matrix in chondrocytes via MMP-13 Streptococcus pyogenes degrades extracellular matrix in chondrocytes via MMP-13 Streptococcus pyogenes degrades extracellular matrix in chondrocytes via MMP-13 Biochemical and Biophysical Research Communications, 373, 3, 450-454 Biochemical and Biophysical Research Communications, 373, 3, 450-454 Biochemical and Biophysical Research Communications, 373, 3, 450-454 2008/08 公開
Tamai K, Tanaka N, Nara A, Yamamoto A, Nakagawa I, Yoshimori T, Ueno Y, Shimosegawa T, Sugamura K. Tamai K, Tanaka N, Nara A, Yamamoto A, Nakagawa I, Yoshimori T, Ueno Y, Shimosegawa T, Sugamura K. Tamai K, Tanaka N, Nara A, Yamamoto A, Nakagawa I, Yoshimori T, Ueno Y, Shimosegawa T, Sugamura K. Role of Hrs in maturation of autophagosomes in mammalian cells. Role of Hrs in maturation of autophagosomes in mammalian cells. Role of Hrs in maturation of autophagosomes in mammalian cells. Biochemical and Biophysical Research Communications, 360, 4, 721-727 Biochemical and Biophysical Research Communications, 360, 4, 721-727 Biochemical and Biophysical Research Communications, 360, 4, 721-727 2007/09 公開
Nakano K, Lapirattanakul J, Nomura R, Nemoto H, Alaluusua S, Groenroos L, Vaara M, Hamada S, Oshima T, Nakagawa I. Nakano K, Lapirattanakul J, Nomura R, Nemoto H, Alaluusua S, Groenroos L, Vaara M, Hamada S, Oshima T, Nakagawa I. Nakano K, Lapirattanakul J, Nomura R, Nemoto H, Alaluusua S, Groenroos L, Vaara M, Hamada S, Oshima T, Nakagawa I. Streptococcus mutans clonal variation revealed by multilocus sequence typing Streptococcus mutans clonal variation revealed by multilocus sequence typing Streptococcus mutans clonal variation revealed by multilocus sequence typing Journal of Clinical Microbiology, 45, 8, 2616-2625 Journal of Clinical Microbiology, 45, 8, 2616-2625 Journal of Clinical Microbiology, 45, 8, 2616-2625 2007/08 公開
Kato T, Kawai S, Nakano K, Inaba H, Kuboniwa M, Nakagawa I, Tsuda K, Omori H, Ooshima T, Yoshimori T, Amano A. Kato T, Kawai S, Nakano K, Inaba H, Kuboniwa M, Nakagawa I, Tsuda K, Omori H, Ooshima T, Yoshimori T, Amano A. Kato T, Kawai S, Nakano K, Inaba H, Kuboniwa M, Nakagawa I, Tsuda K, Omori H, Ooshima T, Yoshimori T, Amano A. Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype Cellular Microbiology, 9, 3, 753-765 Cellular Microbiology, 9, 3, 753-765 Cellular Microbiology, 9, 3, 753-765 2007/03 公開
Amano A, Nakagawa I, Yoshimori T. Amano A, Nakagawa I, Yoshimori T. Amano A, Nakagawa I, Yoshimori T. Autophagy in innate immunity against intracellular bacteria Autophagy in innate immunity against intracellular bacteria Autophagy in innate immunity against intracellular bacteria Journal of Biochemistry, 140, 2, 161-166 Journal of Biochemistry, 140, 2, 161-166 Journal of Biochemistry, 140, 2, 161-166 2006/08 公開
Nakagawa I. Nakagawa I. Nakagawa I. Genome sequence of an invasive M3 strain of Streptococcus pyogenes. Genome sequence of an invasive M3 strain of Streptococcus pyogenes. Genome sequence of an invasive M3 strain of Streptococcus pyogenes. Nippon saikingaku zasshi. Japanese journal of bacteriology, 61, 3, 317-324 Nippon saikingaku zasshi. Japanese journal of bacteriology, 61, 3, 317-324 Nippon saikingaku zasshi. Japanese journal of bacteriology, 61, 3, 317-324 2006/08 公開
Nakagawa I, Yoshimori T. Nakagawa I, Yoshimori T. Nakagawa I, Yoshimori T. Host defense mechanism by autophagy. Host defense mechanism by autophagy. Host defense mechanism by autophagy. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 51, 10 Suppl, 1507-1514 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 51, 10 Suppl, 1507-1514 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 51, 10 Suppl, 1507-1514 2006/08 公開
Nakagawa I, Inaba H, Yamamura T, Kato T, Kawai S, Ooshima T, Amano A. Nakagawa I, Inaba H, Yamamura T, Kato T, Kawai S, Ooshima T, Amano A. Nakagawa I, Inaba H, Yamamura T, Kato T, Kawai S, Ooshima T, Amano A. Invasion of epithelial cells and proteolysis of cellular focal adhesion components by distinct types of Porphyromonas gingivalis fimbriae. Invasion of epithelial cells and proteolysis of cellular focal adhesion components by distinct types of Porphyromonas gingivalis fimbriae. Invasion of epithelial cells and proteolysis of cellular focal adhesion components by distinct types of Porphyromonas gingivalis fimbriae. Infection and Immunity, 74, 7, 3773-3782 Infection and Immunity, 74, 7, 3773-3782 Infection and Immunity, 74, 7, 3773-3782 2006/07 公開
Takemura A, Nakagawa I, Kawai S, Inaba H, Kato T, Hamada S, Amano A. Takemura A, Nakagawa I, Kawai S, Inaba H, Kato T, Hamada S, Amano A. Takemura A, Nakagawa I, Kawai S, Inaba H, Kato T, Hamada S, Amano A. Inhibitory effects of tumor necrosis factor-alpha on migration of human periodontal ligament cells Inhibitory effects of tumor necrosis factor-alpha on migration of human periodontal ligament cells Inhibitory effects of tumor necrosis factor-alpha on migration of human periodontal ligament cells Journal of Periodontology, 77, 5, 883-890 Journal of Periodontology, 77, 5, 883-890 Journal of Periodontology, 77, 5, 883-890 2006/05 公開
Yamasaki E, Wada A, Kumatori A, Nakagawa I, Funao J, Nakayama M, Hisatsune J, Kimura M, Moss J, Hirayama T. Yamasaki E, Wada A, Kumatori A, Nakagawa I, Funao J, Nakayama M, Hisatsune J, Kimura M, Moss J, Hirayama T. Yamasaki E, Wada A, Kumatori A, Nakagawa I, Funao J, Nakayama M, Hisatsune J, Kimura M, Moss J, Hirayama T. Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation. Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation. Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation. Journal of Biological Chemistry, 281, 16, 11250-11259 Journal of Biological Chemistry, 281, 16, 11250-11259 Journal of Biological Chemistry, 281, 16, 11250-11259 2006/04 公開
Nakagawa I, Hamada S. Nakagawa I, Hamada S. Nakagawa I, Hamada S. Intracellularly invading Streptococcus pyogenes is degraded by autophagic machinery Intracellularly invading Streptococcus pyogenes is degraded by autophagic machinery Intracellularly invading Streptococcus pyogenes is degraded by autophagic machinery International Congress Series, 1289, 250-253 International Congress Series, 1289, 250-253 International Congress Series, 1289, 250-253 2006/04 公開
Inaba H, Kawai S, Kato T, Nakagawa I, Amano A. Inaba H, Kawai S, Kato T, Nakagawa I, Amano A. Inaba H, Kawai S, Kato T, Nakagawa I, Amano A. Association between epithelial cell death and invasion by microspheres conjugated to Porphyromonas gingivalis vesicles with different types of fimbriae. Association between epithelial cell death and invasion by microspheres conjugated to Porphyromonas gingivalis vesicles with different types of fimbriae. Association between epithelial cell death and invasion by microspheres conjugated to Porphyromonas gingivalis vesicles with different types of fimbriae. Infection and Immunity, 74, 1, 734-739 Infection and Immunity, 74, 1, 734-739 Infection and Immunity, 74, 1, 734-739 2006/01 公開
Nakagawa I. Nakagawa I. Nakagawa I. Host defense mechanism by autophagy. Host defense mechanism by autophagy. Host defense mechanism by autophagy. Nippon saikingaku zasshi. Japanese journal of bacteriology, 60, 3, 485-489 Nippon saikingaku zasshi. Japanese journal of bacteriology, 60, 3, 485-489 Nippon saikingaku zasshi. Japanese journal of bacteriology, 60, 3, 485-489 2005/08 公開
Nakano K, Nomura R, Nakagawa I, Hamada S, Ooshima T. Nakano K, Nomura R, Nakagawa I, Hamada S, Ooshima T. Nakano K, Nomura R, Nakagawa I, Hamada S, Ooshima T. Role of glucose side chains with serotype-specific polysaccharide in the cariogenicity of Streptococcus mutans Role of glucose side chains with serotype-specific polysaccharide in the cariogenicity of Streptococcus mutans Role of glucose side chains with serotype-specific polysaccharide in the cariogenicity of Streptococcus mutans Caries Research, 39, 4, 262-268 Caries Research, 39, 4, 262-268 Caries Research, 39, 4, 262-268 2005/07 公開
Tamura K, Nakano K, Nomura R, Miyake S, Nakagawa I, Amano A, Ooshima T. Tamura K, Nakano K, Nomura R, Miyake S, Nakagawa I, Amano A, Ooshima T. Tamura K, Nakano K, Nomura R, Miyake S, Nakagawa I, Amano A, Ooshima T. Distribution of Porphyromonas gingivalis fimA genotypes in Japanese children and adolescents. Distribution of Porphyromonas gingivalis fimA genotypes in Japanese children and adolescents. Distribution of Porphyromonas gingivalis fimA genotypes in Japanese children and adolescents. Journal of Periodontology, 76, 5, 674-679 Journal of Periodontology, 76, 5, 674-679 Journal of Periodontology, 76, 5, 674-679 2005/05 公開
Hamada S, Nakagawa I, Kawabata S. Hamada S, Nakagawa I, Kawabata S. Hamada S, Nakagawa I, Kawabata S. Genetic analysis and virulence factors of group A streptococci that cause severe invasive infectious diseases. Genetic analysis and virulence factors of group A streptococci that cause severe invasive infectious diseases. Genetic analysis and virulence factors of group A streptococci that cause severe invasive infectious diseases. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 50, 3, 253-261 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 50, 3, 253-261 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 50, 3, 253-261 2005/03 公開
Nakagawa I, Amano A, Inaba H, Kawai S, Hamada S. Nakagawa I, Amano A, Inaba H, Kawai S, Hamada S. Nakagawa I, Amano A, Inaba H, Kawai S, Hamada S. Inhibitory effects of Porphyromonas gingivalis fimbriae on interactions between extracellular matrix proteins and cellular integrins. Inhibitory effects of Porphyromonas gingivalis fimbriae on interactions between extracellular matrix proteins and cellular integrins. Inhibitory effects of Porphyromonas gingivalis fimbriae on interactions between extracellular matrix proteins and cellular integrins. Microbes and Infection, 7, 2, 157-163 Microbes and Infection, 7, 2, 157-163 Microbes and Infection, 7, 2, 157-163 2005/02 公開
Tsuda K, Amano A, Umebayashi K, Inaba H, Nakagawa I, Nakanishi Y, Yoshimori T. Tsuda K, Amano A, Umebayashi K, Inaba H, Nakagawa I, Nakanishi Y, Yoshimori T. Tsuda K, Amano A, Umebayashi K, Inaba H, Nakagawa I, Nakanishi Y, Yoshimori T. Molecular dissection of internalization of Porphyromonas gingivalis by cells using fluorescent beads coated with bacterial membrane vesicle. Molecular dissection of internalization of Porphyromonas gingivalis by cells using fluorescent beads coated with bacterial membrane vesicle. Molecular dissection of internalization of Porphyromonas gingivalis by cells using fluorescent beads coated with bacterial membrane vesicle. Cell structure and function, 30, 2, 81-91 Cell structure and function, 30, 2, 81-91 Cell structure and function, 30, 2, 81-91 2005 公開
Nakagawa I. Nakagawa I. Nakagawa I. Autophagy as an Innate Defense System against Invading Pathogenic Bacteria Autophagy as an Innate Defense System against Invading Pathogenic Bacteria Autophagy as an Innate Defense System against Invading Pathogenic Bacteria Journal of Oral Biosciences, 47, 1, 11-17 Journal of Oral Biosciences, 47, 1, 11-17 Journal of Oral Biosciences, 47, 1, 11-17 2005 公開
Nakano K, Nomura R, Shimizu N, Nakagawa I, Hamada S, Ooshima T. Nakano K, Nomura R, Shimizu N, Nakagawa I, Hamada S, Ooshima T. Nakano K, Nomura R, Shimizu N, Nakagawa I, Hamada S, Ooshima T. Development of a PCR method for rapid identification of new Streptococcus mutans serotype k strains. Development of a PCR method for rapid identification of new Streptococcus mutans serotype k strains. Development of a PCR method for rapid identification of new Streptococcus mutans serotype k strains. Journal of Clinical Microbiology, 42, 11, 4925-4930 Journal of Clinical Microbiology, 42, 11, 4925-4930 Journal of Clinical Microbiology, 42, 11, 4925-4930 2004/11 公開
Nakagawa I, Amano A, Mizushima N, Yamamoto A, Yamaguchi H, Kamimoto T, Nara A, Funao J, Nakata M, Tsuda K, Hamada S, Yoshimori T. Nakagawa I, Amano A, Mizushima N, Yamamoto A, Yamaguchi H, Kamimoto T, Nara A, Funao J, Nakata M, Tsuda K, Hamada S, Yoshimori T. Nakagawa I, Amano A, Mizushima N, Yamamoto A, Yamaguchi H, Kamimoto T, Nara A, Funao J, Nakata M, Tsuda K, Hamada S, Yoshimori T. Autophagy defends cells against invading group A Streptococcus. Autophagy defends cells against invading group A Streptococcus. Autophagy defends cells against invading group A Streptococcus. Science (New York, N.Y.), 306, 5698, 1037-1040 Science (New York, N.Y.), 306, 5698, 1037-1040 Science (New York, N.Y.), 306, 5698, 1037-1040 2004/11 公開
Nakagawa I, Nakata M, Kawabata S, Hamada S. Nakagawa I, Nakata M, Kawabata S, Hamada S. Nakagawa I, Nakata M, Kawabata S, Hamada S. Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cells. Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cells. Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cells. Cellular Microbiology, 6, 10, 939-952 Cellular Microbiology, 6, 10, 939-952 Cellular Microbiology, 6, 10, 939-952 2004/10 公開
Nakano K, Kuboniwa M, Nakagawa I, Yamamura T, Nomura R, Okahashi N, Ooshima T, Amano A. Nakano K, Kuboniwa M, Nakagawa I, Yamamura T, Nomura R, Okahashi N, Ooshima T, Amano A. Nakano K, Kuboniwa M, Nakagawa I, Yamamura T, Nomura R, Okahashi N, Ooshima T, Amano A. Comparison of inflammatory changes caused by Porphyromonas gingivalis with distinct fimA genotypes in a mouse abscess model Comparison of inflammatory changes caused by Porphyromonas gingivalis with distinct fimA genotypes in a mouse abscess model Comparison of inflammatory changes caused by Porphyromonas gingivalis with distinct fimA genotypes in a mouse abscess model Oral Microbiology and Immunology, 19, 3, 205-209 Oral Microbiology and Immunology, 19, 3, 205-209 Oral Microbiology and Immunology, 19, 3, 205-209 2004/06 公開
Okamoto S, Kawabata S, Nakagawa I, Okuno Y, Goto T, Sano K, Hamada S. Okamoto S, Kawabata S, Nakagawa I, Okuno Y, Goto T, Sano K, Hamada S. Okamoto S, Kawabata S, Nakagawa I, Okuno Y, Goto T, Sano K, Hamada S. A model of invasive type of Streptococcus pyogenes infection after intranasal superinfection in influenza A virus-infected mice A model of invasive type of Streptococcus pyogenes infection after intranasal superinfection in influenza A virus-infected mice A model of invasive type of Streptococcus pyogenes infection after intranasal superinfection in influenza A virus-infected mice International Congress Series, 1263, C, 733-736 International Congress Series, 1263, C, 733-736 International Congress Series, 1263, C, 733-736 2004/06 公開
Amano A, Nakagawa I, Okahashi N, Hamada N. Amano A, Nakagawa I, Okahashi N, Hamada N. Amano A, Nakagawa I, Okahashi N, Hamada N. Variations of Porphyromonas gingivalis fimbriae in relation to microbial pathogenesis. Variations of Porphyromonas gingivalis fimbriae in relation to microbial pathogenesis. Variations of Porphyromonas gingivalis fimbriae in relation to microbial pathogenesis. Journal of Periodontal Research, 39, 2, 136-142 Journal of Periodontal Research, 39, 2, 136-142 Journal of Periodontal Research, 39, 2, 136-142 2004/04 公開
Okahashi N, Inaba H, Nakagawa I, Yamamura T, Kuboniwa M, Nakayama K, Hamada S, Amano A. Okahashi N, Inaba H, Nakagawa I, Yamamura T, Kuboniwa M, Nakayama K, Hamada S, Amano A. Okahashi N, Inaba H, Nakagawa I, Yamamura T, Kuboniwa M, Nakayama K, Hamada S, Amano A. Porphyromonas gingivalis induces receptor activator of NF-kappaB ligand expression in osteoblasts through the activator protein 1 pathway. Porphyromonas gingivalis induces receptor activator of NF-kappaB ligand expression in osteoblasts through the activator protein 1 pathway. Porphyromonas gingivalis induces receptor activator of NF-kappaB ligand expression in osteoblasts through the activator protein 1 pathway. Infection and Immunity, 72, 3, 1706-1714 Infection and Immunity, 72, 3, 1706-1714 Infection and Immunity, 72, 3, 1706-1714 2004/03 公開
Nakano K, Nomura R, Nakagawa I, Hamada S, Ooshima T. Nakano K, Nomura R, Nakagawa I, Hamada S, Ooshima T. Nakano K, Nomura R, Nakagawa I, Hamada S, Ooshima T. Demonstration of Streptococcus mutans with a cell wall polysaccharide specific to a new serotype, k, in the human oral cavity. Demonstration of Streptococcus mutans with a cell wall polysaccharide specific to a new serotype, k, in the human oral cavity. Demonstration of Streptococcus mutans with a cell wall polysaccharide specific to a new serotype, k, in the human oral cavity. Journal of Clinical Microbiology, 42, 1, 198-202 Journal of Clinical Microbiology, 42, 1, 198-202 Journal of Clinical Microbiology, 42, 1, 198-202 2004/01 公開
Sakurai A, Okahashi N, Nakagawa I, Kawabata S, Amano A, Ooshima T, Hamada S Sakurai A, Okahashi N, Nakagawa I, Kawabata S, Amano A, Ooshima T, Hamada S Sakurai A, Okahashi N, Nakagawa I, Kawabata S, Amano A, Ooshima T, Hamada S Streptococcus pyogenes infection induces septic arthritis with increased production of the receptor activator of the NF-kappaB ligand. Streptococcus pyogenes infection induces septic arthritis with increased production of the receptor activator of the NF-kappaB ligand. Streptococcus pyogenes infection induces septic arthritis with increased production of the receptor activator of the NF-kappaB ligand. Infection and Immunity, 71, 10, 6019-6026 Infection and Immunity, 71, 10, 6019-6026 Infection and Immunity, 71, 10, 6019-6026 2003/10 公開
Nakagawa I, Ogawa Y, Noriyama Y, Nakase H, Yamashita M, Sakaki T. Nakagawa I, Ogawa Y, Noriyama Y, Nakase H, Yamashita M, Sakaki T. Nakagawa I, Ogawa Y, Noriyama Y, Nakase H, Yamashita M, Sakaki T. Chemical preconditioning prevents paradoxical increase in glutamate release during ischemia by activating ATP-dependent potassium channels in gerbil hippocampus. Chemical preconditioning prevents paradoxical increase in glutamate release during ischemia by activating ATP-dependent potassium channels in gerbil hippocampus. Chemical preconditioning prevents paradoxical increase in glutamate release during ischemia by activating ATP-dependent potassium channels in gerbil hippocampus. Experimental Neurology, 183, 1, 180-187 Experimental Neurology, 183, 1, 180-187 Experimental Neurology, 183, 1, 180-187 2003/09 公開
Nakagawa I, Kurokawa K, Yamashita A, Nakata M, Tomiyasu Y, Okahashi N, Kawabata S, Yamazaki K, Shiba T, Yasunaga T, Hayashi H, Hattori M, Hamada S. Nakagawa I, Kurokawa K, Yamashita A, Nakata M, Tomiyasu Y, Okahashi N, Kawabata S, Yamazaki K, Shiba T, Yasunaga T, Hayashi H, Hattori M, Hamada S. Nakagawa I, Kurokawa K, Yamashita A, Nakata M, Tomiyasu Y, Okahashi N, Kawabata S, Yamazaki K, Shiba T, Yasunaga T, Hayashi H, Hattori M, Hamada S. Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution. Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution. Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution. Genome Research, 13, 6A, 1042-1055 Genome Research, 13, 6A, 1042-1055 Genome Research, 13, 6A, 1042-1055 2003/06 公開
Okamoto S, Kawabata S, Nakagawa I, Okuno Y, Goto T, Sano K, Hamada S. Okamoto S, Kawabata S, Nakagawa I, Okuno Y, Goto T, Sano K, Hamada S. Okamoto S, Kawabata S, Nakagawa I, Okuno Y, Goto T, Sano K, Hamada S. Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in mice. Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in mice. Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in mice. Journal of Virology, 77, 7, 4104-4112 Journal of Virology, 77, 7, 4104-4112 Journal of Virology, 77, 7, 4104-4112 2003/04 公開
Okahashi N, Sakurai A, Nakagawa I, Fujiwara T, Kawabata S, Amano A, Hamada S. Okahashi N, Sakurai A, Nakagawa I, Fujiwara T, Kawabata S, Amano A, Hamada S. Okahashi N, Sakurai A, Nakagawa I, Fujiwara T, Kawabata S, Amano A, Hamada S. Infection by Streptococcus pyogenes induces the receptor activator of NF-kappaB ligand expression in mouse osteoblastic cells. Infection by Streptococcus pyogenes induces the receptor activator of NF-kappaB ligand expression in mouse osteoblastic cells. Infection by Streptococcus pyogenes induces the receptor activator of NF-kappaB ligand expression in mouse osteoblastic cells. Infection and Immunity, 71, 2, 948-955 Infection and Immunity, 71, 2, 948-955 Infection and Immunity, 71, 2, 948-955 2003/02 公開
Terao Y, Kawabata S, Nakata M, Nakagawa I, Hamada S. Terao Y, Kawabata S, Nakata M, Nakagawa I, Hamada S. Terao Y, Kawabata S, Nakata M, Nakagawa I, Hamada S. Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes strains isolated from toxic shock-like syndrome patients. Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes strains isolated from toxic shock-like syndrome patients. Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes strains isolated from toxic shock-like syndrome patients. Journal of Biological Chemistry, 277, 49, 47428-47435 Journal of Biological Chemistry, 277, 49, 47428-47435 Journal of Biological Chemistry, 277, 49, 47428-47435 2002/12 公開
Nakagawa I, Amano A, Ohara-Nemoto Y, Endoh N, Morisaki I, Kimura S, Kawabata S, Hamada S. Nakagawa I, Amano A, Ohara-Nemoto Y, Endoh N, Morisaki I, Kimura S, Kawabata S, Hamada S. Nakagawa I, Amano A, Ohara-Nemoto Y, Endoh N, Morisaki I, Kimura S, Kawabata S, Hamada S. Identification of a new variant of fimA gene of Porphyromonas gingivalis and its distribution in adults and disabled populations with periodontitis Identification of a new variant of fimA gene of Porphyromonas gingivalis and its distribution in adults and disabled populations with periodontitis Identification of a new variant of fimA gene of Porphyromonas gingivalis and its distribution in adults and disabled populations with periodontitis Journal of Periodontal Research, 37, 6, 425-432 Journal of Periodontal Research, 37, 6, 425-432 Journal of Periodontal Research, 37, 6, 425-432 2002/12 公開
Kawabata S, Tamura Y, Murakami J, Terao Y, Nakagawa I, Hamada S. Kawabata S, Tamura Y, Murakami J, Terao Y, Nakagawa I, Hamada S. Kawabata S, Tamura Y, Murakami J, Terao Y, Nakagawa I, Hamada S. A novel, anchorless streptococcal surface protein that binds to human immunoglobulins. A novel, anchorless streptococcal surface protein that binds to human immunoglobulins. A novel, anchorless streptococcal surface protein that binds to human immunoglobulins. Biochemical and Biophysical Research Communications, 296, 5, 1329-1333 Biochemical and Biophysical Research Communications, 296, 5, 1329-1333 Biochemical and Biophysical Research Communications, 296, 5, 1329-1333 2002/09 公開
Nakagawa I, Nakata M, Yamamura T, Wakisaka S, Kawabata S, Hamada S. Nakagawa I, Nakata M, Yamamura T, Wakisaka S, Kawabata S, Hamada S. Nakagawa I, Nakata M, Yamamura T, Wakisaka S, Kawabata S, Hamada S. Infection and pathogenesis of a murine strain of Escherichia coli with genetically introduced Shiga toxin type I operon in conventional mice. Infection and pathogenesis of a murine strain of Escherichia coli with genetically introduced Shiga toxin type I operon in conventional mice. Infection and pathogenesis of a murine strain of Escherichia coli with genetically introduced Shiga toxin type I operon in conventional mice. Microbial Pathogenesis, 33, 2, 63-72 Microbial Pathogenesis, 33, 2, 63-72 Microbial Pathogenesis, 33, 2, 63-72 2002/08 公開
Nakagawa I, Nakase H, Aketa S, Kamada Y, Yamashita M, Sakaki T. Nakagawa I, Nakase H, Aketa S, Kamada Y, Yamashita M, Sakaki T. Nakagawa I, Nakase H, Aketa S, Kamada Y, Yamashita M, Sakaki T. ATP-dependent potassium channel mediates neuroprotection by chemical preconditioning with 3-nitropropionic acid in gerbil hippocampus. ATP-dependent potassium channel mediates neuroprotection by chemical preconditioning with 3-nitropropionic acid in gerbil hippocampus. ATP-dependent potassium channel mediates neuroprotection by chemical preconditioning with 3-nitropropionic acid in gerbil hippocampus. Neuroscience Letters, 320, 1-2, 33-36 Neuroscience Letters, 320, 1-2, 33-36 Neuroscience Letters, 320, 1-2, 33-36 2002/03 公開
Terao Y, Kawabata S, Kunitomo E, Nakagawa I, Hamada S. Terao Y, Kawabata S, Kunitomo E, Nakagawa I, Hamada S. Terao Y, Kawabata S, Kunitomo E, Nakagawa I, Hamada S. Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cells. Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cells. Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cells. Infection and Immunity, 70, 2, 993-997 Infection and Immunity, 70, 2, 993-997 Infection and Immunity, 70, 2, 993-997 2002/02 公開
Nakagawa I, Amano A, Kuboniwa M, Nakamura T, Kawabata S, Hamada S. Nakagawa I, Amano A, Kuboniwa M, Nakamura T, Kawabata S, Hamada S. Nakagawa I, Amano A, Kuboniwa M, Nakamura T, Kawabata S, Hamada S. Functional differences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial cells. Functional differences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial cells. Functional differences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial cells. Infection and Immunity, 70, 1, 277-285 Infection and Immunity, 70, 1, 277-285 Infection and Immunity, 70, 1, 277-285 2002/01 公開
Nakano K, Matsumura M, Kawaguchi M, Fujiwara T, Sobue S, Nakagawa I, Hamada S, Ooshima T. Nakano K, Matsumura M, Kawaguchi M, Fujiwara T, Sobue S, Nakagawa I, Hamada S, Ooshima T. Nakano K, Matsumura M, Kawaguchi M, Fujiwara T, Sobue S, Nakagawa I, Hamada S, Ooshima T. Attenuation of glucan-binding protein C reduces the cariogenicity of Streptococcus mutans: Analysis of strains isolated from human blood Attenuation of glucan-binding protein C reduces the cariogenicity of Streptococcus mutans: Analysis of strains isolated from human blood Attenuation of glucan-binding protein C reduces the cariogenicity of Streptococcus mutans: Analysis of strains isolated from human blood Journal of Dental Research, 81, 6, 376-379 Journal of Dental Research, 81, 6, 376-379 Journal of Dental Research, 81, 6, 376-379 2002 公開
Murakami J, Kawabata S, Terao Y, Kikuchi K, Totsuka K, Tamaru A, Katsukawa C, Moriya K, Nakagawa I, Morisaki I, Hamada S. Murakami J, Kawabata S, Terao Y, Kikuchi K, Totsuka K, Tamaru A, Katsukawa C, Moriya K, Nakagawa I, Morisaki I, Hamada S. Murakami J, Kawabata S, Terao Y, Kikuchi K, Totsuka K, Tamaru A, Katsukawa C, Moriya K, Nakagawa I, Morisaki I, Hamada S. Distribution of emm genotypes and superantigen genes of Streptococcus pyogenes isolated in Japan, 1994-9 Distribution of emm genotypes and superantigen genes of Streptococcus pyogenes isolated in Japan, 1994-9 Distribution of emm genotypes and superantigen genes of Streptococcus pyogenes isolated in Japan, 1994-9 Epidemiology and Infection, 128, 3, 397-404 Epidemiology and Infection, 128, 3, 397-404 Epidemiology and Infection, 128, 3, 397-404 2002 公開
Fujiwara T, Nakano K, Kawaguchi M, Ooshima T, Sobue S, Kawabata S, Nakagawa I, Hamada S. Fujiwara T, Nakano K, Kawaguchi M, Ooshima T, Sobue S, Kawabata S, Nakagawa I, Hamada S. Fujiwara T, Nakano K, Kawaguchi M, Ooshima T, Sobue S, Kawabata S, Nakagawa I, Hamada S. Biochemical and genetic characterization of serologically untypable Streptococcus mutans strains isolated from patients with bacteremia Biochemical and genetic characterization of serologically untypable Streptococcus mutans strains isolated from patients with bacteremia Biochemical and genetic characterization of serologically untypable Streptococcus mutans strains isolated from patients with bacteremia European Journal of Oral Sciences, 109, 5, 330-334 European Journal of Oral Sciences, 109, 5, 330-334 European Journal of Oral Sciences, 109, 5, 330-334 2001/10 公開
Amano A, Kishima T, Akiyama S, Nakagawa I, Hamada S, Morisaki I. Amano A, Kishima T, Akiyama S, Nakagawa I, Hamada S, Morisaki I. Amano A, Kishima T, Akiyama S, Nakagawa I, Hamada S, Morisaki I. Relationship of periodontopathic bacteria with early-onset periodontitis in Down's syndrome Relationship of periodontopathic bacteria with early-onset periodontitis in Down's syndrome Relationship of periodontopathic bacteria with early-onset periodontitis in Down's syndrome Journal of Periodontology, 72, 3, 368-373 Journal of Periodontology, 72, 3, 368-373 Journal of Periodontology, 72, 3, 368-373 2001/03 公開
Terao Y, Kawabata S, Kunitomo E, Murakami J, Nakagawa I, Hamada S. Terao Y, Kawabata S, Kunitomo E, Murakami J, Nakagawa I, Hamada S. Terao Y, Kawabata S, Kunitomo E, Murakami J, Nakagawa I, Hamada S. Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator Molecular Microbiology, 42, 1, 75-86 Molecular Microbiology, 42, 1, 75-86 Molecular Microbiology, 42, 1, 75-86 2001 公開
Amano A, Premaraj T, Kuboniwa M, Nakagawa I, Shizukuishi S, Morisaki I, Hamada S. Amano A, Premaraj T, Kuboniwa M, Nakagawa I, Shizukuishi S, Morisaki I, Hamada S. Amano A, Premaraj T, Kuboniwa M, Nakagawa I, Shizukuishi S, Morisaki I, Hamada S. Altered antigenicity in periodontitis patients and decreased adhesion of Porphyromonas gingivalis by environmental temperature stress Altered antigenicity in periodontitis patients and decreased adhesion of Porphyromonas gingivalis by environmental temperature stress Altered antigenicity in periodontitis patients and decreased adhesion of Porphyromonas gingivalis by environmental temperature stress Oral Microbiology and Immunology, 16, 2, 124-128 Oral Microbiology and Immunology, 16, 2, 124-128 Oral Microbiology and Immunology, 16, 2, 124-128 2001 公開
Okamoto S, Kawabata S, Nakagawa I, Hamada S. Okamoto S, Kawabata S, Nakagawa I, Hamada S. Okamoto S, Kawabata S, Nakagawa I, Hamada S. Administration of superantigens protects mice from lethal Listeria monocytogenes infection by enhancing cytotoxic T cells Administration of superantigens protects mice from lethal Listeria monocytogenes infection by enhancing cytotoxic T cells Administration of superantigens protects mice from lethal Listeria monocytogenes infection by enhancing cytotoxic T cells Infection and Immunity, 69, 11, 6633-6642 Infection and Immunity, 69, 11, 6633-6642 Infection and Immunity, 69, 11, 6633-6642 2001 公開
Kuboniwa M, Amano A, Shizukuishi S, Nakagawa I, Hamada S. Kuboniwa M, Amano A, Shizukuishi S, Nakagawa I, Hamada S. Kuboniwa M, Amano A, Shizukuishi S, Nakagawa I, Hamada S. Specific antibodies to Porphyromonas gingivalis lys-gingipain by DNA vaccination inhibit bacterial binding to hemoglobin and protect mice from infection Specific antibodies to Porphyromonas gingivalis lys-gingipain by DNA vaccination inhibit bacterial binding to hemoglobin and protect mice from infection Specific antibodies to Porphyromonas gingivalis lys-gingipain by DNA vaccination inhibit bacterial binding to hemoglobin and protect mice from infection Infection and Immunity, 69, 5, 2972-2979 Infection and Immunity, 69, 5, 2972-2979 Infection and Immunity, 69, 5, 2972-2979 2001 公開
Kawabata S, Kunitomo E, Terao Y, Nakagawa I, Kikuchi K, Totsuka K-I, Hamada S. Kawabata S, Kunitomo E, Terao Y, Nakagawa I, Kikuchi K, Totsuka K-I, Hamada S. Kawabata S, Kunitomo E, Terao Y, Nakagawa I, Kikuchi K, Totsuka K-I, Hamada S. Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge in mice Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge in mice Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge in mice Infection and Immunity, 69, 2, 924-930 Infection and Immunity, 69, 2, 924-930 Infection and Immunity, 69, 2, 924-930 2001 公開
Nakagawa I, Nakata M, Kawabata S, Hamada S. Nakagawa I, Nakata M, Kawabata S, Hamada S. Nakagawa I, Nakata M, Kawabata S, Hamada S. Cytochrome c-mediated caspase-9 activation triggers apoptosis in Streptococcus pyogenes-infected epithelial cells Cytochrome c-mediated caspase-9 activation triggers apoptosis in Streptococcus pyogenes-infected epithelial cells Cytochrome c-mediated caspase-9 activation triggers apoptosis in Streptococcus pyogenes-infected epithelial cells Cellular Microbiology, 3, 6, 395-405 Cellular Microbiology, 3, 6, 395-405 Cellular Microbiology, 3, 6, 395-405 2001 公開
Amano A, Kuboniwa M, Nakagawa I, Akiyama S, Morisaki I, Hamada S. Amano A, Kuboniwa M, Nakagawa I, Akiyama S, Morisaki I, Hamada S. Amano A, Kuboniwa M, Nakagawa I, Akiyama S, Morisaki I, Hamada S. Prevalence of specific genotypes of Porphyromonas gingivalis fimA and periodontal health status Prevalence of specific genotypes of Porphyromonas gingivalis fimA and periodontal health status Prevalence of specific genotypes of Porphyromonas gingivalis fimA and periodontal health status Journal of Dental Research, 79, 9, 1664-1668 Journal of Dental Research, 79, 9, 1664-1668 Journal of Dental Research, 79, 9, 1664-1668 2000 公開
Nakagawa I, Amano A, Kimura R.K, Nakamura T, Kawabata S, Hamada S. Nakagawa I, Amano A, Kimura R.K, Nakamura T, Kawabata S, Hamada S. Nakagawa I, Amano A, Kimura R.K, Nakamura T, Kawabata S, Hamada S. Distribution and molecular characterization of Porphyromonas gingivalis carrying a new type of fimA gene Distribution and molecular characterization of Porphyromonas gingivalis carrying a new type of fimA gene Distribution and molecular characterization of Porphyromonas gingivalis carrying a new type of fimA gene Journal of Clinical Microbiology, 38, 5, 1909-1914 Journal of Clinical Microbiology, 38, 5, 1909-1914 Journal of Clinical Microbiology, 38, 5, 1909-1914 2000 公開
Kimura S, Tamamura T, Nakagawa I, Koga T, Fujiwara T, Hamada S. Kimura S, Tamamura T, Nakagawa I, Koga T, Fujiwara T, Hamada S. Kimura S, Tamamura T, Nakagawa I, Koga T, Fujiwara T, Hamada S. CD14-dependent and independent pathways in lipopolysaccharide-induced activation of a murine B-cell line, CH12.LX CD14-dependent and independent pathways in lipopolysaccharide-induced activation of a murine B-cell line, CH12.LX CD14-dependent and independent pathways in lipopolysaccharide-induced activation of a murine B-cell line, CH12.LX Scandinavian Journal of Immunology, 51, 4, 392-399 Scandinavian Journal of Immunology, 51, 4, 392-399 Scandinavian Journal of Immunology, 51, 4, 392-399 2000 公開
Kawabata S, Terao Y, Fujiwara T, Nakagawa I, Hamada S. Kawabata S, Terao Y, Fujiwara T, Nakagawa I, Hamada S. Kawabata S, Terao Y, Fujiwara T, Nakagawa I, Hamada S. Targeted salivary gland immunization with plasmid DNA elicits specific salivary immunoglobulin A and G antibodies and serum immunoglobulin G antibodies in mice Targeted salivary gland immunization with plasmid DNA elicits specific salivary immunoglobulin A and G antibodies and serum immunoglobulin G antibodies in mice Targeted salivary gland immunization with plasmid DNA elicits specific salivary immunoglobulin A and G antibodies and serum immunoglobulin G antibodies in mice Infection and Immunity, 67, 11, 5863-5868 Infection and Immunity, 67, 11, 5863-5868 Infection and Immunity, 67, 11, 5863-5868 1999/11 公開
Kawabata S, Kuwata H, Nakagawa I, Morimatsu S, Sano K, Hamada S. Kawabata S, Kuwata H, Nakagawa I, Morimatsu S, Sano K, Hamada S. Kawabata S, Kuwata H, Nakagawa I, Morimatsu S, Sano K, Hamada S. Capsular hyaluronic acid of group A streptococci hampers their invasion into human pharyngeal epithelial cells Capsular hyaluronic acid of group A streptococci hampers their invasion into human pharyngeal epithelial cells Capsular hyaluronic acid of group A streptococci hampers their invasion into human pharyngeal epithelial cells Microbial Pathogenesis, 27, 2, 71-80 Microbial Pathogenesis, 27, 2, 71-80 Microbial Pathogenesis, 27, 2, 71-80 1999/08 公開
Nakamura T, Amano A, Nakagawa I, Hamada S. Nakamura T, Amano A, Nakagawa I, Hamada S. Nakamura T, Amano A, Nakagawa I, Hamada S. Specific interactions between Porphyromonas gingivalis fimbriae and human extracellular matrix proteins Specific interactions between Porphyromonas gingivalis fimbriae and human extracellular matrix proteins Specific interactions between Porphyromonas gingivalis fimbriae and human extracellular matrix proteins FEMS Microbiology Letters, 175, 2, 267-272 FEMS Microbiology Letters, 175, 2, 267-272 FEMS Microbiology Letters, 175, 2, 267-272 1999/06 公開
Amano A, Nakamura T, Kimura S, Morisaki I, Nakagawa I, Kawabata S, Hamada S. Amano A, Nakamura T, Kimura S, Morisaki I, Nakagawa I, Kawabata S, Hamada S. Amano A, Nakamura T, Kimura S, Morisaki I, Nakagawa I, Kawabata S, Hamada S. Molecular interactions of Porphyromonas gingivalis fimbriae with host proteins: Kinetic analyses based on surface plasmon resonance Molecular interactions of Porphyromonas gingivalis fimbriae with host proteins: Kinetic analyses based on surface plasmon resonance Molecular interactions of Porphyromonas gingivalis fimbriae with host proteins: Kinetic analyses based on surface plasmon resonance Infection and Immunity, 67, 5, 2399-2405 Infection and Immunity, 67, 5, 2399-2405 Infection and Immunity, 67, 5, 2399-2405 1999/05 公開
Amano A, Nakagawa I, Kataoka K, Morisaki I, Hamada S. Amano A, Nakagawa I, Kataoka K, Morisaki I, Hamada S. Amano A, Nakagawa I, Kataoka K, Morisaki I, Hamada S. Distribution of Porphyromonas gingivalis strains with fimA genotypes in periodontitis patients Distribution of Porphyromonas gingivalis strains with fimA genotypes in periodontitis patients Distribution of Porphyromonas gingivalis strains with fimA genotypes in periodontitis patients Journal of Clinical Microbiology, 37, 5, 1426-1430 Journal of Clinical Microbiology, 37, 5, 1426-1430 Journal of Clinical Microbiology, 37, 5, 1426-1430 1999 公開
Amano A, Nakagawa I, Hamada S. Amano A, Nakagawa I, Hamada S. Amano A, Nakagawa I, Hamada S. Studying initial phase of biofllm formation: Molecular interaction of host proteins and bacterial surface components Studying initial phase of biofllm formation: Molecular interaction of host proteins and bacterial surface components Studying initial phase of biofllm formation: Molecular interaction of host proteins and bacterial surface components Methods in Enzymology, 310, 494-501 Methods in Enzymology, 310, 494-501 Methods in Enzymology, 310, 494-501 1999 公開
Kontani M, Amano A, Nakamura T, Nakagawa I, Kawabata S, Hamada S. Kontani M, Amano A, Nakamura T, Nakagawa I, Kawabata S, Hamada S. Kontani M, Amano A, Nakamura T, Nakagawa I, Kawabata S, Hamada S. Inhibitory effects of protamines on proteolytic and adhesive activities of Porphyromonas gingivalis Inhibitory effects of protamines on proteolytic and adhesive activities of Porphyromonas gingivalis Inhibitory effects of protamines on proteolytic and adhesive activities of Porphyromonas gingivalis Infection and Immunity, 67, 9, 4917-4920 Infection and Immunity, 67, 9, 4917-4920 Infection and Immunity, 67, 9, 4917-4920 1999 公開
Nakagawa I, Nakata M, Kawabata S, Hamada S. Nakagawa I, Nakata M, Kawabata S, Hamada S. Nakagawa I, Nakata M, Kawabata S, Hamada S. Regulated expression of the Shiga toxin B gene induces apoptosis in mammalian fibroblastic cells Regulated expression of the Shiga toxin B gene induces apoptosis in mammalian fibroblastic cells Regulated expression of the Shiga toxin B gene induces apoptosis in mammalian fibroblastic cells Molecular Microbiology, 33, 6, 1190-1199 Molecular Microbiology, 33, 6, 1190-1199 Molecular Microbiology, 33, 6, 1190-1199 1999 公開
Amano A, Nakagawa I, Hamada S. Amano A, Nakagawa I, Hamada S. Amano A, Nakagawa I, Hamada S. Studying initial phase of biofilm formation: Molecular interaction of host proteins and bacterial surface components Studying initial phase of biofilm formation: Molecular interaction of host proteins and bacterial surface components Studying initial phase of biofilm formation: Molecular interaction of host proteins and bacterial surface components Methods in Enzymology, 310, 501-513 Methods in Enzymology, 310, 501-513 Methods in Enzymology, 310, 501-513 1999 公開
Takemura A, Matsuda N, Kimura S, Fujiwara T, Nakagawa I, Hamada S. Takemura A, Matsuda N, Kimura S, Fujiwara T, Nakagawa I, Hamada S. Takemura A, Matsuda N, Kimura S, Fujiwara T, Nakagawa I, Hamada S. Porphyromonas gingivalis lipopolysaccharide modulates the responsiveness of human periodontal ligament fibroblasts to platelet-derived growth factor Porphyromonas gingivalis lipopolysaccharide modulates the responsiveness of human periodontal ligament fibroblasts to platelet-derived growth factor Porphyromonas gingivalis lipopolysaccharide modulates the responsiveness of human periodontal ligament fibroblasts to platelet-derived growth factor Journal of Periodontal Research, 33, 7, 400-407 Journal of Periodontal Research, 33, 7, 400-407 Journal of Periodontal Research, 33, 7, 400-407 1998/10 公開
Hamada S, Amano A, Kimura S, Nakagawa I, Kawabata S, Morisaki I. Hamada S, Amano A, Kimura S, Nakagawa I, Kawabata S, Morisaki I. Hamada S, Amano A, Kimura S, Nakagawa I, Kawabata S, Morisaki I. The importance of fimbriae in the virulence and ecology of some oral bacteria The importance of fimbriae in the virulence and ecology of some oral bacteria The importance of fimbriae in the virulence and ecology of some oral bacteria Oral Microbiology and Immunology, 13, 3, 129-138 Oral Microbiology and Immunology, 13, 3, 129-138 Oral Microbiology and Immunology, 13, 3, 129-138 1998/06 公開
Kontani M, Kimura S, Nakagawa I, Hamada S. Kontani M, Kimura S, Nakagawa I, Hamada S. Kontani M, Kimura S, Nakagawa I, Hamada S. Adherence of Porphyromonas gingivalis to matrix proteins via a fimbrial cryptic receptor exposed by its own arginine-specific protease Adherence of Porphyromonas gingivalis to matrix proteins via a fimbrial cryptic receptor exposed by its own arginine-specific protease Adherence of Porphyromonas gingivalis to matrix proteins via a fimbrial cryptic receptor exposed by its own arginine-specific protease Molecular Microbiology, 24, 6, 1179-1187 Molecular Microbiology, 24, 6, 1179-1187 Molecular Microbiology, 24, 6, 1179-1187 1997 公開
Takahashi I, Nakagawa I, Xu L, Hamada S. Takahashi I, Nakagawa I, Xu L, Hamada S. Takahashi I, Nakagawa I, Xu L, Hamada S. Role of αβ T cells and γδ T cells in protective immunity to Actinobacillus actinomycetemcomitans in mutant mice by targeted gene disruption Role of αβ T cells and γδ T cells in protective immunity to Actinobacillus actinomycetemcomitans in mutant mice by targeted gene disruption Role of αβ T cells and γδ T cells in protective immunity to Actinobacillus actinomycetemcomitans in mutant mice by targeted gene disruption Journal of Periodontal Research, 31, 8, 589-595 Journal of Periodontal Research, 31, 8, 589-595 Journal of Periodontal Research, 31, 8, 589-595 1996/11 公開
Takahashi I, Marinaro M, Kiyono H, Jackson R.J, Nakagawa I, Fujihashi K, Hamada S, Clements J.D, Bost K.L, McGhee J.R. Takahashi I, Marinaro M, Kiyono H, Jackson R.J, Nakagawa I, Fujihashi K, Hamada S, Clements J.D, Bost K.L, McGhee J.R. Takahashi I, Marinaro M, Kiyono H, Jackson R.J, Nakagawa I, Fujihashi K, Hamada S, Clements J.D, Bost K.L, McGhee J.R. Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin Journal of Infectious Diseases, 173, 3, 627-635 Journal of Infectious Diseases, 173, 3, 627-635 Journal of Infectious Diseases, 173, 3, 627-635 1996 公開
Nakagawa I, Takahashi I, Kiyono I, McGhee J.R, Hamada S. Nakagawa I, Takahashi I, Kiyono I, McGhee J.R, Hamada S. Nakagawa I, Takahashi I, Kiyono I, McGhee J.R, Hamada S. Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches Journal of Infectious Diseases, 173, 6, 1428-1436 Journal of Infectious Diseases, 173, 6, 1428-1436 Journal of Infectious Diseases, 173, 6, 1428-1436 1996 公開
Takahashi I, Nakagawa I, Xu L, Hamada S. Takahashi I, Nakagawa I, Xu L, Hamada S. Takahashi I, Nakagawa I, Xu L, Hamada S. IL-12 rescues galactosamine-loaded mice from lethal shock triggered by staphylococcal enterotoxin IL-12 rescues galactosamine-loaded mice from lethal shock triggered by staphylococcal enterotoxin IL-12 rescues galactosamine-loaded mice from lethal shock triggered by staphylococcal enterotoxin Biochemical and Biophysical Research Communications, 217, 1, 74-80 Biochemical and Biophysical Research Communications, 217, 1, 74-80 Biochemical and Biophysical Research Communications, 217, 1, 74-80 1995/12 公開
Takahashi I, Nakagawa I, Kiyono H, McGhee J.R, Clements J.D, Hamada S. Takahashi I, Nakagawa I, Kiyono H, McGhee J.R, Clements J.D, Hamada S. Takahashi I, Nakagawa I, Kiyono H, McGhee J.R, Clements J.D, Hamada S. Mucosal T cells induce systemic anergy for oral tolerance Mucosal T cells induce systemic anergy for oral tolerance Mucosal T cells induce systemic anergy for oral tolerance Biochemical and Biophysical Research Communications, 206, 1, 414-420 Biochemical and Biophysical Research Communications, 206, 1, 414-420 Biochemical and Biophysical Research Communications, 206, 1, 414-420 1995/01 公開
Fujiwara T, Nakagawa I, Morishima S, Takahashi I, Hamada S. Fujiwara T, Nakagawa I, Morishima S, Takahashi I, Hamada S. Fujiwara T, Nakagawa I, Morishima S, Takahashi I, Hamada S. Inconsistency between the fimbrilin gene and the antigenicity of lipopolysaccharides in selected strains of Porphyromonas gingivalis Inconsistency between the fimbrilin gene and the antigenicity of lipopolysaccharides in selected strains of Porphyromonas gingivalis Inconsistency between the fimbrilin gene and the antigenicity of lipopolysaccharides in selected strains of Porphyromonas gingivalis FEMS Microbiology Letters, 124, 3, 333-341 FEMS Microbiology Letters, 124, 3, 333-341 FEMS Microbiology Letters, 124, 3, 333-341 1994/12 公開
Fujiwara T, Morishima S, Takahashi I, Nakagawa I, Kimura S, Ogawa T, Hamada S. Fujiwara T, Morishima S, Takahashi I, Nakagawa I, Kimura S, Ogawa T, Hamada S. Fujiwara T, Morishima S, Takahashi I, Nakagawa I, Kimura S, Ogawa T, Hamada S. Molecular and Immunological Characterization of the Fimbriae of Porphyromonas gingivalis Molecular and Immunological Characterization of the Fimbriae of Porphyromonas gingivalis Molecular and Immunological Characterization of the Fimbriae of Porphyromonas gingivalis Microbiology and Immunology, 38, 12, 921-930 Microbiology and Immunology, 38, 12, 921-930 Microbiology and Immunology, 38, 12, 921-930 1994 公開
Infection and pathogenesis of a ** strain of Escherichia coli with genetically introduced Shiga toxin type I operon Infection and pathogenesis of a ** strain of Escherichia coli with genetically introduced Shiga toxin type I operon Microb Pathog, 33, 2, 63-72 , 33, 2, 63-72 Microb Pathog, 33, 2, 63-72 2002 公開
Systemic and mucosal immunization with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pysgenes infection Systemic and mucosal immunization with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pysgenes infection Infect. Immun, 69, 2, 924-930 , 69, 2, 924-930 Infect. Immun, 69, 2, 924-930 2001 公開
Altered autigevicity in periodontitis patients and decreased adhesion of Porphyromonas gingivalis Altered autigevicity in periodontitis patients and decreased adhesion of Porphyromonas gingivalis Oral Microbiol Immunol, 16, 2, 124-128 , 16, 2, 124-128 Oral Microbiol Immunol, 16, 2, 124-128 2001 公開

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タイトル言語:
Misc
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
P. gingivalis線毛遺伝子型による分布と、健康状態との関連 P. gingivalis線毛遺伝子型による分布と、健康状態との関連 , 79, 9, 1664 , 79, 9, 1664 , 79, 9, 1664 2000 公開
p. gingivalis の新しい線毛遺伝子型を保有する株の分布とその特徴 p. gingivalis の新しい線毛遺伝子型を保有する株の分布とその特徴 , 38, 5, 1909 , 38, 5, 1909 , 38, 5, 1909 2000 公開
マウスB細胞株CH12LXにおけるCD14依存性非依存性のLPSによる活性化機構 マウスB細胞株CH12LXにおけるCD14依存性非依存性のLPSによる活性化機構 , 51, 4, 392 , 51, 4, 392 , 51, 4, 392 2000 公開
歯周病患者におけるP.gingivalis fim遺伝子型による分布 歯周病患者におけるP.gingivalis fim遺伝子型による分布 , 37, 1426 , 37, 1426 , 37, 1426 1999 公開
P.gingivalis線毛と宿主タンパク質の分子間相互作用:表面プラズモン共鳴に基づいたカイネテック分析 P.gingivalis線毛と宿主タンパク質の分子間相互作用:表面プラズモン共鳴に基づいたカイネテック分析 , 67, 2399 , 67, 2399 , 67, 2399 1999 公開
P.gingivalisのタンパク分解及び接着に対するプロタミンの阻害作用 P.gingivalisのタンパク分解及び接着に対するプロタミンの阻害作用 , 67, 4917 , 67, 4917 , 67, 4917 1999 公開
A群レンサ球菌の夾膜ヒアルロン酸による咽頭上皮細胞への侵入阻害 A群レンサ球菌の夾膜ヒアルロン酸による咽頭上皮細胞への侵入阻害 , 27, 71 , 27, 71 , 27, 71 1999 公開
細胞内での志賀毒素Bサブユニットの発現誘導によるアポトーシスの誘導 細胞内での志賀毒素Bサブユニットの発現誘導によるアポトーシスの誘導 , 33, 1190 , 33, 1190 , 33, 1190 1999 公開
アルギニン特異的プロテアーゼを介したP.gingivalisのマトリックス蛋白への結合 アルギニン特異的プロテアーゼを介したP.gingivalisのマトリックス蛋白への結合 , 24, 6, 1179 , 24, 6, 1179 , 24, 6, 1179 1997 公開
大腸菌易熱性毒素Bサブユニットによる腸管パイエル板でのTh1,Th2型T細胞の誘導 大腸菌易熱性毒素Bサブユニットによる腸管パイエル板でのTh1,Th2型T細胞の誘導 , 173, 6, 1428 , 173, 6, 1428 , 173, 6, 1428 1996 公開
大腸菌易熱性毒素の粘膜免疫原性の解析 大腸菌易熱性毒素の粘膜免疫原性の解析 , 173, 635 , 173, 635 , 173, 635 1996 公開
P.gingivalisにおけるフィンブリリン遺伝子とLPS抗原性の不一致 P.gingivalisにおけるフィンブリリン遺伝子とLPS抗原性の不一致 , 124, 3, 333 , 124, 3, 333 , 124, 3, 333 1994 公開

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タイトル言語:
学術賞等
賞の名称(日本語) 賞の名称(英語) 授与組織名(日本語) 授与組織名(英語) 年月
黒屋奨励賞 日本細菌学会 Japanese Sciety for Bacteriology 1998/03/20
若手科学者賞 The Young Scientists' Prize 文部科学省 The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology 1998/04/15
外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
挑戦的萌芽研究 代表 Genome Editing法を応用した遺伝子破壊導入による細菌感染制御法の開発 (平成26年度分) 2014/04/01〜2015/03/31
新学術領域研究 代表 A群レンサ球菌の感染細胞内でのファージを介したゲノムアダプテーション (平成26年度分) 2014/04/01〜2015/03/31
基盤研究(B) 代表 細菌感染によるAtg5依存・非依存オートファージーの分解と炎症誘導メカニズムの解析 (平成26年度分) 2014/04/01〜2015/03/31
基盤研究(B) 代表 レンサ球菌属のCRISPRスペーサー配列解析による新規流行株予測法の確立 (平成26年度分) 2014/04/01〜2015/03/31
基盤研究(B) 代表 レンサ球菌属のCRISPRスペーサー配列解析による新規流行株予測法の確立 (平成27年度分) 2015/04/01〜2016/03/31
基盤研究(B) 代表 細菌感染によるAtg5依存・非依存オートファジーの分解と炎症誘導メカニズムの解析 (平成27年度分) 2015/04/01〜2016/03/31
挑戦的萌芽研究 代表 ライブイメージングにより細菌感染過程と感染特異的なオートファジーを可視化する (平成27年度分) 2015/04/01〜2016/03/31
挑戦的萌芽研究 代表 ライブイメージングにより細菌感染過程と感染特異的なオートファジーを可視化する (平成28年度分) 2016/04/01〜2017/03/31
基盤研究(B) 代表 A群レンサ球菌特異的糖鎖を認識するオートファジー誘導機構の解析 (平成28年度分) 2016/04/01〜2017/03/31
挑戦的研究(萌芽) 代表 分子間インタラクションに基づく細菌種に特異的な創薬基盤の開発 (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(B) 代表 A群レンサ球菌特異的糖鎖を認識するオートファジー誘導機構の解析 (平成29年度分) 2017/04/01〜2018/03/31
国際共同研究加速基金(国際共同研究強化(B)) 代表 薬剤耐性菌の出現抑制を目的とした豚レンサ球菌感染症の新規診断・治療法の基盤開発 (平成30年度分) 2018/04/01〜2019/03/31
挑戦的研究(萌芽) 代表 分子間インタラクションに基づく細菌種に特異的な創薬基盤の開発 (平成30年度分) 2018/04/01〜2019/03/31
基盤研究(B) 代表 A群レンサ球菌特異的糖鎖を認識するオートファジー誘導機構の解析 (平成30年度分) 2018/04/01〜2019/03/31

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担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
微生物学 II Microbiology II 前期不定 医学研究科 2014/04〜2015/03
微生物学 I Microbiology I 前期不定 医学研究科 2014/04〜2015/03
B2a 微生物学講義 Microbiology 前期 医学部 2015/04〜2016/03
B2b 微生物学実習 Laboratory Course in Microbiology 前期 医学部 2015/04〜2016/03
B3 寄生虫学 Medical Parasitology 前期 医学部 2015/04〜2016/03
医科学研究 Laboratory visit 前期不定 医学研究科 2015/04〜2016/03
微生物学 II Microbiology II 前期不定 医学研究科 2015/04〜2016/03
微生物学 I Microbiology I 前期不定 医学研究科 2015/04〜2016/03
B2a 微生物学講義 Microbiology 前期 医学部 2016/04〜2017/03
B2b 微生物学実習 Laboratory Course in Microbiology 前期 医学部 2016/04〜2017/03
B3 寄生虫学 Medical Parasitology 前期 医学部 2016/04〜2017/03
微生物学 II Microbiology II 前期不定 医学研究科 2016/04〜2017/03
微生物学 I Microbiology I 前期不定 医学研究科 2016/04〜2017/03
B2a 微生物学講義 Microbiology 前期 医学部 2017/04〜2018/03
B2b 微生物学実習 Laboratory Course in Microbiology 前期 医学部 2017/04〜2018/03
B3 寄生虫学 Medical Parasitology 前期 医学部 2017/04〜2018/03
B7a 微生物学 Microbiology 後期後半 医学部 2017/04〜2018/03
B7b 微生物学実習 Laboratory Course in Microbiology 後期後半 医学部 2017/04〜2018/03
微生物学 II Microbiology II 後期不定 医学研究科 2017/04〜2018/03
微生物学 I Microbiology I 後期不定 医学研究科 2017/04〜2018/03
B2a 微生物学講義 Microbiology 前期 医学部 2018/04〜2019/03
B2b 微生物学実習 Laboratory Course in Microbiology 前期 医学部 2018/04〜2019/03
B3 寄生虫学 Medical Parasitology 前期 医学部 2018/04〜2019/03
B7a 微生物学 Microbiology 後期後半 医学部 2018/04〜2019/03
B7b 微生物学実習 Laboratory Course in Microbiology 後期後半 医学部 2018/04〜2019/03
微生物学 II Microbiology II 後期不定 医学研究科 2018/04〜2019/03
微生物学 I Microbiology I 後期不定 医学研究科 2018/04〜2019/03
感染症学I Infectious disease medicine I 後期 医学部(人間健康科学科) 2018/04〜2019/03
B2a 微生物学講義 Microbiology 前期 医学部 2019/04〜2020/03
B2b 微生物学実習 Laboratory Course in Microbiology 前期 医学部 2019/04〜2020/03
B3 寄生虫学 Medical Parasitology 前期 医学部 2019/04〜2020/03
B7a 微生物学 Microbiology 後期後半 医学部 2019/04〜2020/03
B7b 微生物学実習 Laboratory Course in Microbiology 後期後半 医学部 2019/04〜2020/03
微生物学 II Microbiology II 後期不定 医学研究科 2019/04〜2020/03
微生物学 I Microbiology I 後期不定 医学研究科 2019/04〜2020/03
感染症学I Infectious disease medicine I 後期 医学部(人間健康科学科) 2019/04〜2020/03

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全学運営(役職等)
役職名 期間
組換えDNA実験安全委員会 1号委員 2017/04/01〜2021/03/31
組換えDNA実験安全主任者 2018/04/01〜
入学試験企画・研究専門委員会 2018/04/01〜2020/03/31
組換えDNA実験安全委員会 委員 2019/04/01〜2021/03/31
部局運営(役職等)
役職名 期間
期限付特定教員採用審査委員会 2014/11/01〜2018/10/31
医学図書館運営委員会 2017/04/01〜2019/03/31
医学研究科運営委員会 〜2019/09/30
学務委員会 2018/04/01〜2020/03/31
入学者選抜方法検討委員会 2017/04/01〜2021/03/31
大倉辰三郎・喜美奨学金 選考小委員会 2018/04/01〜2020/03/31
総合博物館協議員会 2019/04/01〜2021/03/31
学会活動:学会役員歴
学会名(日本語) 学会名(英語) 役職名(日本語) 役職名(英語) 期間
日本細菌学会 Japanese Society for Bacteriology 理事 2015/04/01〜