保川 清

最終更新日時: 2017/06/15 15:49:40

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氏名(漢字/フリガナ/アルファベット表記)
保川 清/ヤスカワ キヨシ/Kiyoshi Yasukawa
所属部署・職名(部局/所属/講座等/職名)
農学研究科/食品生物科学専攻食品生命科学講座/教授
学部兼担
部局 所属 講座等 職名
農学部
連絡先住所
種別 住所(日本語) 住所(英語)
職場 京都府京都市左京区北白川追分町 Kitashirakawa, Sakyo-ku, Kyoto, 6068502, Japan
連絡先電話番号
種別 番号
職場 075-753-6266
所属学会(国内)
学会名(日本語) 学会名(英語)
日本生化学会 Japanese Biochemical Society
日本農芸化学会 Japan Society for Bioscience, Biotechnology, and Agrochemistry
日本生物工学会 The Society for Biotechnology, Japan
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
理学修士 東京大学
医学博士 大阪大学
出身大学院・研究科等
大学名(日本語) 大学名(英語) 研究科名(日本語) 研究科名(英語) 専攻名(日本語) 専攻名(英語) 修了区分
東京大学 大学院理学系研究科修士課程生物化学専攻 修了
職歴
期間 組織名(日本語) 組織名(英語) 職名(日本語) 職名(英語)
1984/04/02〜2004/09/30 東ソー株式会社 Tosoh Corporation
2004/10/01〜2007/03/31 京都大学 Kyoto University 助教授 Associate Professor
2007/04/1〜2013/07/31 京都大学 Kyoto University 准教授 Associate Professor
2013/08/01〜 京都大学 Kyoto University 教授 Professor
プロフィール
(日本語)
酵素は生物の営む多様な反応を効率よく行うだけでなく、産業上でも広く応用されている。今後、エネルギーや環境という視点から酵素利用はますます重要視されるであろう。私は遺伝子工学、蛋白質工学を駆使して有用酵素を創製し、酵素の新しい応用面を切り開き、食品工業と医薬工業に酵素を利用することを目指している。さらに、酵素の構造と機能の関係を分子レベルで理解することにも取り組みたい。
(英語)
Enzymes are proteins having catalytic activity. Biological reactions are accelerated and accurately controlled by enzymes in organisms. On the other hand, enzymes are widely used in industry. We are aiming at elucidating the relationship between structure and function of enzymes at a molecular level and developing new methods for application of enzymes in food and medical technologies by generating new enzyme functions and controlling enzyme reactions. We are focusing our activities mainly on the following subjects.
研究テーマ
(日本語)
酵素の機能改変と用途拡大
(英語)
Generation and application of enzyme functions
研究概要
(日本語)
酵素の構造と機能の関係を分子レベルで理解することと、有用酵素の創製や酵素反応の制御を通して酵素の新しい応用面を切り開き、食品工業と医薬工業への酵素利用を目指している。
(英語)
We are aiming at elucidating the relationship between structure and function of enzymes at a molecular level and developing new methods for application of enzymes in food and medical technologies by generating new enzyme functions and controlling enzyme reactions.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
酵素 Enzyme
バイオテクノロジー Biotechnology
触媒活性 Catalytic acitivty
安定性 Stability
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 出版年月 査読の有無 記述言語 掲載種別 公開
Samukange, V., Yasukawa, K., and Inouye, K. Samukange, V., Yasukawa, K., and Inouye, K. Samukange, V., Yasukawa, K., and Inouye, K. Effects of heparin and cholesterol sulfate on the activity and stability of human matrix metalloproteinase 7 Effects of heparin and cholesterol sulfate on the activity and stability of human matrix metalloproteinase 7 Effects of heparin and cholesterol sulfate on the activity and stability of human matrix metalloproteinase 7 Biosci. Biotechnol. Biochem.,78,41-48 2014 公開
Konishi, A., Ma, X., and Yasukawa, K. Konishi, A., Ma, X., and Yasukawa, K. Konishi, A., Ma, X., and Yasukawa, K. Stabilization of Moloney murine leukemia virus reverse transcriptase by site-directed mutagenesis of the surface residue Val433 Stabilization of Moloney murine leukemia virus reverse transcriptase by site-directed mutagenesis of the surface residue Val433 Stabilization of Moloney murine leukemia virus reverse transcriptase by site-directed mutagenesis of the surface residue Val433 Biosci. Biotechnol. Biochem. 78: 147-150,78,147-150 2014 英語 公開
Samukange, V., Kamo, M., Yasukawa, K., and Inouye, K. Samukange, V., Kamo, M., Yasukawa, K., and Inouye, K. Samukange, V., Kamo, M., Yasukawa, K., and Inouye, K. Effects of salts on the Interaction of 8-anilinonaphthalene 1-sulphonate and thermolysin Effects of salts on the Interaction of 8-anilinonaphthalene 1-sulphonate and thermolysin Effects of salts on the Interaction of 8-anilinonaphthalene 1-sulphonate and thermolysin Biosci. Biotechnol. Biochem.,78,522-528 2014 英語 公開
Hisayoshi, T., Shinomura, M., Konishi, A., Tanaka, J., Shimoda, H., Hata, K., Takahashi, S., and Yasukawa, K. Hisayoshi, T., Shinomura, M., Konishi, A., Tanaka, J., Shimoda, H., Hata, K., Takahashi, S., and Yasukawa, K. Hisayoshi, T., Shinomura, M., Konishi, A., Tanaka, J., Shimoda, H., Hata, K., Takahashi, S., and Yasukawa, K. Inhibition of HIV-1 reverse transcriptase activity by Brasenia schreberi (Junsai) components Inhibition of HIV-1 reverse transcriptase activity by Brasenia schreberi (Junsai) components Inhibition of HIV-1 reverse transcriptase activity by Brasenia schreberi (Junsai) components J. Biol. Macromol.,14,59-65 2014 英語 公開
Konishi, A., Hisayoshi, T. Yokokawa, K., Barrioluengo, V., Menéndez-Arias, L., and Yasukawa, K. Konishi, A., Hisayoshi, T. Yokokawa, K., Barrioluengo, V., Menéndez-Arias, L., and Yasukawa, K. Konishi, A., Hisayoshi, T. Yokokawa, K., Barrioluengo, V., Menéndez-Arias, L., and Yasukawa, K. Amino acid substitutions away from the RNase H catalytic site increase the thermal stability of Moloney murine leukemia virus reverse transcriptase through RNase H inactivation Amino acid substitutions away from the RNase H catalytic site increase the thermal stability of Moloney murine leukemia virus reverse transcriptase through RNase H inactivation Amino acid substitutions away from the RNase H catalytic site increase the thermal stability of Moloney murine leukemia virus reverse transcriptase through RNase H inactivation Biophys. Res. Commun.,454,269-274 2014 英語 公開
Y. Kawasaki; K. Yasukawa; K. Inouye Y. Kawasaki; K. Yasukawa; K. Inouye Effects of site-directed mutagenesis in the N-terminal domain of thermolysin on its stabilization Effects of site-directed mutagenesis in the N-terminal domain of thermolysin on its stabilization ,153,1,85-92 2013/01 英語 公開
A. Konishi; M. Shinomura; K. Yasukawa A. Konishi; M. Shinomura; K. Yasukawa Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase for use in cDNA synthesis Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase for use in cDNA synthesis ,169,1,77-87 2013/01 英語 公開
E. Menach; K. Yasukawa; K. Inouye E. Menach; K. Yasukawa; K. Inouye Effects of mutations of thermolysin, Asn116 to Asp and Asp150 to Glu, on salt-induced activation and stabilization Effects of mutations of thermolysin, Asn116 to Asp and Asp150 to Glu, on salt-induced activation and stabilization ,77,4,741-746 2013 英語 公開
E. Menach; Y. Hashida; K. Yasukawa; K. Inouye E. Menach; Y. Hashida; K. Yasukawa; K. Inouye Effects of conversion of the zinc-binding motif sequence of thermolysin, HEXXH, to that of dipeptidyl peptidase III, HEXXXH, on the activity and stability of thermolysin Effects of conversion of the zinc-binding motif sequence of thermolysin, HEXXH, to that of dipeptidyl peptidase III, HEXXXH, on the activity and stability of thermolysin ,77,9,1901-1906 2013 英語 公開
K. Nishimura; M. Shinomura; A. Konishi; K. Yasukawa K. Nishimura; M. Shinomura; A. Konishi; K. Yasukawa Stabilization of human immunodeficiency virus type 1 reverse transcriptase by site-directed mutagenesis Stabilization of human immunodeficiency virus type 1 reverse transcriptase by site-directed mutagenesis ,35,12,2165-2175 2013 英語 公開
K. Yasukawa; A. Konishi; M. Shinomura; E. Nagaoka; S. Fujiwara K. Yasukawa; A. Konishi; M. Shinomura; E. Nagaoka; S. Fujiwara Kinetic analysis of reverse transcriptase activity of bacterial family A DNA polymerases Kinetic analysis of reverse transcriptase activity of bacterial family A DNA polymerases ,427,3,654-658 2012/10/26 英語 公開
E. Menach; K. Yasukawa; K. Inouye E. Menach; K. Yasukawa; K. Inouye Effects of site-directed mutagenesis of Asn116 in the β-hairpin of the N-terminal domain of thermolysin on its activity and stability Effects of site-directed mutagenesis of Asn116 in the β-hairpin of the N-terminal domain of thermolysin on its activity and stability ,152,3,231-239 2012/09 英語 公開
A. Konishi; K. Yasukawa; K. Inouye A. Konishi; K. Yasukawa; K. Inouye Improving the thermal stability of avian myeloblastosis virus reverse transcriptase α-subunit by site-directed mutagenesis Improving the thermal stability of avian myeloblastosis virus reverse transcriptase α-subunit by site-directed mutagenesis ,34,7,1209-1215 2012/07 英語 公開
V. Samukange; K. Yasukawa; K. Inouye V. Samukange; K. Yasukawa; K. Inouye Interaction of 8-anilinonaphthalene 1-sulphonate (ANS) and human matrix metalloproteinase 7 (MMP-7) as examined by MMP-7 activity and ANS fluorescence Interaction of 8-anilinonaphthalene 1-sulphonate (ANS) and human matrix metalloproteinase 7 (MMP-7) as examined by MMP-7 activity and ANS fluorescence ,151,5,533-540 2012/05 英語 公開
S. Sekiguchi; Y. Hashida; K. Yasukawa; K. Inouyey S. Sekiguchi; Y. Hashida; K. Yasukawa; K. Inouyey Stabilization of bovine intestine alkaline phosphatase by sugars Stabilization of bovine intestine alkaline phosphatase by sugars ,76,1,95-100 2012/01 英語 公開
A. Morishima; K. Yasukawa; K. Inouye A. Morishima; K. Yasukawa; K. Inouye A possibility of a protein-bound water molecule as the ionizable group responsible for pKe at the alkaline side in human matrix metalloproteinase 7 activity A possibility of a protein-bound water molecule as the ionizable group responsible for pKe at the alkaline side in human matrix metalloproteinase 7 activity ,151,5,501-509 2012 英語 公開
H. Takeharu; K. Yasukawa; K. Inouye H. Takeharu; K. Yasukawa; K. Inouye Thermodynamic analysis of ionizable groups involved in the catalytic mechanism of human matrix metalloproteinase 7 (MMP-7) Thermodynamic analysis of ionizable groups involved in the catalytic mechanism of human matrix metalloproteinase 7 (MMP-7) ,1814,12,1940-1946 2011/12 英語 公開
S. Sekiguchi; K. Yasukawa; K. Inouye S. Sekiguchi; K. Yasukawa; K. Inouye Effects of polyethylene glycol on bovine intestine alkaline phosphatase activity and stability Effects of polyethylene glycol on bovine intestine alkaline phosphatase activity and stability ,75,11,2132-2137 2011/11 英語 公開
T. Miyake; K. Yasukawa; K. Inouye T. Miyake; K. Yasukawa; K. Inouye Analysis of the mechanism of inhibition of human matrix metalloproteinase 7 (MMP-7) activity by green tea catechins Analysis of the mechanism of inhibition of human matrix metalloproteinase 7 (MMP-7) activity by green tea catechins ,75,8,1564-1569 2011/08 英語 公開
A. Konishi; D. Nemoto; K. Yasukawa; K. Inouye A. Konishi; D. Nemoto; K. Yasukawa; K. Inouye Comparison of the thermal stabilities of the βα heterodimer and the α subunit of avian myeloblastosis virus reverse transcriptase Comparison of the thermal stabilities of the βα heterodimer and the α subunit of avian myeloblastosis virus reverse transcriptase ,75,8,1618-1620 2011/08 英語 公開
S. Sekiguchi; Y. Hashida; K. Yasukawa; K. Inouye S. Sekiguchi; Y. Hashida; K. Yasukawa; K. Inouye Effects of amines and aminoalcohols on bovine intestine alkaline phosphatase activity Effects of amines and aminoalcohols on bovine intestine alkaline phosphatase activity ,49,2,171-176 2011/07/10 英語 公開
S. Sekiguchi; H. Kohno; K. Yasukawa; K. Inouye S. Sekiguchi; H. Kohno; K. Yasukawa; K. Inouye Chemiluminescent enzyme immunoassay for measuring leptin Chemiluminescent enzyme immunoassay for measuring leptin ,75,4,752-756 2011/04 英語 公開
E. Menach; K. Yasukawa; K. Inouye E. Menach; K. Yasukawa; K. Inouye Effects of site-directed mutagenesis of the loop residue of the N-terminal domain Gly117 of thermolysin on its catalytic activity Effects of site-directed mutagenesis of the loop residue of the N-terminal domain Gly117 of thermolysin on its catalytic activity ,74,12,2457-2462 2010/12 英語 公開
K. Yasukawa; M. Mizuno; A. Konishi; K. Inouye K. Yasukawa; M. Mizuno; A. Konishi; K. Inouye Increase in thermal stability of Moloney murine leukaemia virus reverse transcriptase by site-directed mutagenesis Increase in thermal stability of Moloney murine leukaemia virus reverse transcriptase by site-directed mutagenesis ,150,3,299-306 2010/11 英語 公開
K. Yasukawa; A. Konishi; K. Inouye K. Yasukawa; A. Konishi; K. Inouye Effects of organic solvents on the reverse transcription reaction catalyzed by reverse transcriptases from avian myeloblastosis virus and moloney murine leukemia virus Effects of organic solvents on the reverse transcription reaction catalyzed by reverse transcriptases from avian myeloblastosis virus and moloney murine leukemia virus ,74,9,1925-1930 2010/09 英語 公開
M. Kusano; K. Yasukawa; K. Inouye M. Kusano; K. Yasukawa; K. Inouye Effects of the mutational combinations on the activity and stability of thermolysin Effects of the mutational combinations on the activity and stability of thermolysin ,147,1,7-16 2010/05/03 英語 公開
K. Yasukawa; N. Agata; K. Inouye K. Yasukawa; N. Agata; K. Inouye Detection of cesA mRNA from Bacillus cereus by RNA-specific amplification Detection of cesA mRNA from Bacillus cereus by RNA-specific amplification ,46,5,391-396 2010/04/05 英語 公開
M. Kusano; K. Yasukawa; K. Inouye M. Kusano; K. Yasukawa; K. Inouye Synthesis of N-carbobenzoxy-l-aspartyl-l-phenylalanine methyl ester catalyzed by thermolysin variants with improved activity Synthesis of N-carbobenzoxy-l-aspartyl-l-phenylalanine methyl ester catalyzed by thermolysin variants with improved activity ,46,3-4,320-325 2010/03/05 英語 公開
M. Mizuno; K. Yasukawa; K. Inouye M. Mizuno; K. Yasukawa; K. Inouye Insight into the mechanism of the stabilization of moloney murine leukaemia virus reverse transcriptase by eliminating RNase H activity Insight into the mechanism of the stabilization of moloney murine leukaemia virus reverse transcriptase by eliminating RNase H activity ,74,2,440-442 2010/02 英語 公開
H. Sakurama; T. Takita; B. Mikami; T. Itoh; K. Yasukawa; K. Inouye H. Sakurama; T. Takita; B. Mikami; T. Itoh; K. Yasukawa; K. Inouye Two crystal structures of lysyl-tRNA synthetase from Bacillus stearothermophilus in complex with lysyladenylate-like compounds: Insights into the irreversible formation of the enzyme-bound adenylate of L-lysine hydroxamate Two crystal structures of lysyl-tRNA synthetase from Bacillus stearothermophilus in complex with lysyladenylate-like compounds: Insights into the irreversible formation of the enzyme-bound adenylate of L-lysine hydroxamate ,145,5,555-563 2009/05 英語 公開
K. Asaoka; K. Yasukawa; K. Inouye K. Asaoka; K. Yasukawa; K. Inouye Coagulation of soy proteins induced by thermolysin and comparison of the coagulation reaction with that induced by subtilisin Carlsberg Coagulation of soy proteins induced by thermolysin and comparison of the coagulation reaction with that induced by subtilisin Carlsberg ,44,4,229-234 2009/04/06 英語 公開
K. Yasukawa; M. Mizuno; K. Inouye K. Yasukawa; M. Mizuno; K. Inouye Characterization of Moloney murine leukaemia virus/avian myeloblastosis virus chimeric reverse transcriptases Characterization of Moloney murine leukaemia virus/avian myeloblastosis virus chimeric reverse transcriptases ,145,3,315-324 2009/03 英語 公開
K. Inouye; K. Nakano; K. Asaoka; K. Yasukawa K. Inouye; K. Nakano; K. Asaoka; K. Yasukawa Effects of thermal treatment on the coagulation of soy proteins induced by subtilisin Carlsberg Effects of thermal treatment on the coagulation of soy proteins induced by subtilisin Carlsberg ,57,2,717-723 2009/01/28 英語 公開
M. Kusano; K. Yasukawa; K. Inouye M. Kusano; K. Yasukawa; K. Inouye Insights into the catalytic roles of the polypeptide regions in the active site of thermolysin and generation of the thermolysin variants with high activity and stability Insights into the catalytic roles of the polypeptide regions in the active site of thermolysin and generation of the thermolysin variants with high activity and stability ,145,1,103-113 2009/01 英語 公開
K. Inouye; M. Nakano; K. Asaoka; K. Yasukawa K. Inouye; M. Nakano; K. Asaoka; K. Yasukawa Erratum: Effects of Thermal Treatment on the Coagulation of Soy Proteins Induced by Subtilisin Carlsberg (Journal of Agricultural and Food Chemistry 57 (717)) Erratum: Effects of Thermal Treatment on the Coagulation of Soy Proteins Induced by Subtilisin Carlsberg (Journal of Agricultural and Food Chemistry 57 (717)) ,57,24,11581- 2009 英語 公開
T. Takita; T. Aono; H. Sakurama; T. Itoh; T. Wada; M. Minoda; K. Yasukawa; K. Inouye T. Takita; T. Aono; H. Sakurama; T. Itoh; T. Wada; M. Minoda; K. Yasukawa; K. Inouye Effects of introducing negative charges into the molecular surface of thermolysin by site-directed mutagenesis on its activity and stability Effects of introducing negative charges into the molecular surface of thermolysin by site-directed mutagenesis on its activity and stability ,1784,3,481-488 2008/03 英語 公開
K. Yasukawa; D. Nemoto; K. Inouye K. Yasukawa; D. Nemoto; K. Inouye Comparison of the thermal stabilities of reverse transcriptases from avian myeloblastosis virus and moloney murine leukaemia virus Comparison of the thermal stabilities of reverse transcriptases from avian myeloblastosis virus and moloney murine leukaemia virus ,143,2,261-268 2008/02 英語 公開
K. Yasukawa; K. Inouye K. Yasukawa; K. Inouye Improving the activity and stability of thermolysin by site-directed mutagenesis Improving the activity and stability of thermolysin by site-directed mutagenesis ,1774,10,1281-1288 2007/10 英語 公開
K. Inouye; T. Shimada; K. Yasukawa K. Inouye; T. Shimada; K. Yasukawa Effects of neutral salts and alcohols on the activity of Streptomyces caespitosus neutral protease Effects of neutral salts and alcohols on the activity of Streptomyces caespitosus neutral protease ,142,3,317-324 2007/09 英語 公開
K. Inouye; K. Nakamura; M. Kusano; K. Yasukawa K. Inouye; K. Nakamura; M. Kusano; K. Yasukawa Improvement in performance of affinity gels containing Gly-D-Phe as a ligand to thermolysin due to increasing the spacer chain length Improvement in performance of affinity gels containing Gly-D-Phe as a ligand to thermolysin due to increasing the spacer chain length ,71,8,2083-2086 2007/08 英語 公開
K. Yasukawa; M. Kusano; K. Inouye K. Yasukawa; M. Kusano; K. Inouye A new method for the extracellular production of recombinant thermolysin by co-expressing the mature sequence and pro-sequence in Escherichia coli A new method for the extracellular production of recombinant thermolysin by co-expressing the mature sequence and pro-sequence in Escherichia coli ,20,8,375-383 2007/08 英語 公開
K. Inouye; T. Shimada; K. Yasukawa K. Inouye; T. Shimada; K. Yasukawa Purification to homogeneity of a neutral metalloproteinase from Streptomyces caespitosus Purification to homogeneity of a neutral metalloproteinase from Streptomyces caespitosus ,71,7,1773-1776 2007/07 英語 公開
C. Tatsumi; Y. Hashida; K. Yasukawa; K. Inouye C. Tatsumi; Y. Hashida; K. Yasukawa; K. Inouye Effects of site-directed mutagenesis of the surface residues Gln128 and Gln225 of thermolysin on its catalytic activity Effects of site-directed mutagenesis of the surface residues Gln128 and Gln225 of thermolysin on its catalytic activity ,141,6,835-842 2007/06 英語 公開
K. Inouye; M. Kusano; Y. Hashida; M. Minoda; K. Yasukawa K. Inouye; M. Kusano; Y. Hashida; M. Minoda; K. Yasukawa Engineering, expression, purification, and production of recombinant thermolysin Engineering, expression, purification, and production of recombinant thermolysin ,13,43-64 2007 英語 公開
M. Kusano; K. Yasukawa; Y. Hashida; K. Inouye M. Kusano; K. Yasukawa; Y. Hashida; K. Inouye Engineering of the pH-dependence of thermolysin activity as examined by site-directed mutagenesis of Asn112 located at the active site of thermolysin Engineering of the pH-dependence of thermolysin activity as examined by site-directed mutagenesis of Asn112 located at the active site of thermolysin ,139,6,1017-1023 2006/06 英語 公開
K. Inouye; M. Minoda; T. Takita; H. Sakurama; Y. Hashida; M. Kusano; K. Yasukawa K. Inouye; M. Minoda; T. Takita; H. Sakurama; Y. Hashida; M. Kusano; K. Yasukawa Extracellular production of recombinant thermolysin expressed in Escherichia coli, and its purification and enzymatic characterization Extracellular production of recombinant thermolysin expressed in Escherichia coli, and its purification and enzymatic characterization ,46,2,248-255 2006/04 英語 公開
K. Yasukawa; M. Kusano; K. Nakamura; K. Inouye K. Yasukawa; M. Kusano; K. Nakamura; K. Inouye Characterization of Gly-D-Phe, Gly-L-Leu, and D-Phe as affinity ligands to thermolysin Characterization of Gly-D-Phe, Gly-L-Leu, and D-Phe as affinity ligands to thermolysin ,46,2,332-336 2006/04 英語 公開
T. Tatekawa; H. Ogawa; M. Kawakami; Y. Oka; K. Yasukawa; H. Sugiyama; I. Kawase; T. Soma T. Tatekawa; H. Ogawa; M. Kawakami; Y. Oka; K. Yasukawa; H. Sugiyama; I. Kawase; T. Soma A novel direct competitive repopulation assay for human hematopoietic stem cells using NOD/SCID mice A novel direct competitive repopulation assay for human hematopoietic stem cells using NOD/SCID mice ,8,4,390-398 2006 英語 公開
S. Takakura; S. Tsuchiya; Y. Isawa; K. Yasukawa; T. Hayashi; M. Tomita; K. Suzuki; T. Hasegawa; T. Tagami; A. Kurashima; S. Ichiyama S. Takakura; S. Tsuchiya; Y. Isawa; K. Yasukawa; T. Hayashi; M. Tomita; K. Suzuki; T. Hasegawa; T. Tagami; A. Kurashima; S. Ichiyama Rapid detection of Mycobacterium tuberculosis in respiratory samples by transcription-reverse transcription concerted reaction with an automated system Rapid detection of Mycobacterium tuberculosis in respiratory samples by transcription-reverse transcription concerted reaction with an automated system ,43,11,5435-5439 2005/11 英語 公開
S. Takakura; S. Tsuchiya; N. Fujihara; T. Kudo; Y. Iinuma; S. Mitarai; S. Ichiyama; K. Yasukawa; T. Ishiguro S. Takakura; S. Tsuchiya; N. Fujihara; T. Kudo; Y. Iinuma; S. Mitarai; S. Ichiyama; K. Yasukawa; T. Ishiguro Isothermal RNA sequence amplification method for rapid antituberculosis drug susceptibility testing of Mycobacterium tuberculosis Isothermal RNA sequence amplification method for rapid antituberculosis drug susceptibility testing of Mycobacterium tuberculosis ,43,5,2489-2491 2005/05 英語 公開
N. Masuda; K. Yasukawa; Y. Isawa; R. Horie; J. Saitoh; T. Ishiguro; Y. Nakaguchi; M. Nishibuchi; T. Hayashi N. Masuda; K. Yasukawa; Y. Isawa; R. Horie; J. Saitoh; T. Ishiguro; Y. Nakaguchi; M. Nishibuchi; T. Hayashi Rapid detection of tdh and trh mRNAs of Vibrio parahaemolyticus by the transcription-reverse transcription concerted (TRC) method Rapid detection of tdh and trh mRNAs of Vibrio parahaemolyticus by the transcription-reverse transcription concerted (TRC) method ,98,4,236-243 2004/10 英語 公開
Y. Nakaguchi; T. Ishizuka; S. Ohnaka; T. Hayashi; K. Yasukawa; T. Ishiguro; M. Nishibuchi Y. Nakaguchi; T. Ishizuka; S. Ohnaka; T. Hayashi; K. Yasukawa; T. Ishiguro; M. Nishibuchi Rapid and specific detection of tdh, trh1, and trh2 mRNA of Vibrio parahaemolyticus by transcription-reverse transcription concerted reaction with an automated system Rapid and specific detection of tdh, trh1, and trh2 mRNA of Vibrio parahaemolyticus by transcription-reverse transcription concerted reaction with an automated system ,42,9,4284-4292 2004/09 英語 公開
K. Yasukawa; S. Tsuchiya; T. Ekida; H. Iida; T. Ide; D. Miki; H. Yagame; K. Murayama; T. Ishiguro K. Yasukawa; S. Tsuchiya; T. Ekida; H. Iida; T. Ide; D. Miki; H. Yagame; K. Murayama; T. Ishiguro Fusion protein of interleukin-6 and interleukin-6 receptor without a polypeptide linker Fusion protein of interleukin-6 and interleukin-6 receptor without a polypeptide linker ,96,1,38-46 2003/07 英語 公開
T. Ishiguro; J. Saitoh; R. Horie; T. Hayashi; T. Ishizuka; S. Tsuchiya; K. Yasukawa; T. Kido; Y. Nakaguchi; M. Nishibuchi; K. Ueda T. Ishiguro; J. Saitoh; R. Horie; T. Hayashi; T. Ishizuka; S. Tsuchiya; K. Yasukawa; T. Kido; Y. Nakaguchi; M. Nishibuchi; K. Ueda Intercalation activating fluorescence DNA probe and its application to homogeneous quantification of a target sequence by isothermal sequence amplification in a closed vessel Intercalation activating fluorescence DNA probe and its application to homogeneous quantification of a target sequence by isothermal sequence amplification in a closed vessel ,314,1,77-86 2003/03/01 英語 公開
T. Takizawa; M. Yanagisawa; W. Ochiai; K. Yasukawa; T. Ishiguro; K. Nakashima; T. Taga T. Takizawa; M. Yanagisawa; W. Ochiai; K. Yasukawa; T. Ishiguro; K. Nakashima; T. Taga Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3 Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3 ,13,5,272-279 2001/03/07 英語 公開
H. Mizuguchi; H. Mizuno; K. Yasukawa; T. Ishiguro; K. Fukui; T. Imanaka; M. Takagi H. Mizuguchi; H. Mizuno; K. Yasukawa; T. Ishiguro; K. Fukui; T. Imanaka; M. Takagi Enhanced signal transduction by a directly fused protein of interleukin-6 and its receptor Enhanced signal transduction by a directly fused protein of interleukin-6 and its receptor ,91,3,299-304 2001/03 英語 公開
H. Minamiguchi; N. Yahata; T. Kimura; H. Fujiki; S. Harada; J. Wang; K. Okuda; H. Kaneko; K. Hodohara; T. Banba; K. Yasukawa; J.H. Ohyashiki; K. Ohyashiki; T. Abe; Y. Sonoda H. Minamiguchi; N. Yahata; T. Kimura; H. Fujiki; S. Harada; J. Wang; K. Okuda; H. Kaneko; K. Hodohara; T. Banba; K. Yasukawa; J.H. Ohyashiki; K. Ohyashiki; T. Abe; Y. Sonoda Interleukin 6 receptor expression by human cord blood- or peripheral blood-derived primitive haematopoietic progenitors implies acquisition of different functional properties Interleukin 6 receptor expression by human cord blood- or peripheral blood-derived primitive haematopoietic progenitors implies acquisition of different functional properties ,110,2,327-338 2000/08 英語 公開
H. Mizuguchi; T. Kubomi; R. Nomura; K. Yasukawa; T. Imanaka; M. Takagi H. Mizuguchi; T. Kubomi; R. Nomura; K. Yasukawa; T. Imanaka; M. Takagi Screening of an oligopeptide antagonist for interleukin-6 from a random phage library Screening of an oligopeptide antagonist for interleukin-6 from a random phage library ,22,12,1015-1020 2000/06 英語 公開
H. Mitani; N. Katayama; H. Araki; K. Ohishi; K. Kobayashi; H. Suzuki; K. Nishii; M. Masuya; K. Yasukawa; N. Minami; H. Shiku H. Mitani; N. Katayama; H. Araki; K. Ohishi; K. Kobayashi; H. Suzuki; K. Nishii; M. Masuya; K. Yasukawa; N. Minami; H. Shiku Activity of interleukin 6 in the differentiation of monocytes to macrophages and dendritic cells Activity of interleukin 6 in the differentiation of monocytes to macrophages and dendritic cells ,109,2,288-295 2000/05 英語 公開
T. Ueda; K. Tsuji; H. Yoshino; Y. Ebihara; H. Yagasaki; H. Hisakawa; T. Mitsui; A. Manabe; R. Tanaka; K. Kobayashi; M. Ito; K. Yasukawa; T. Nakahata T. Ueda; K. Tsuji; H. Yoshino; Y. Ebihara; H. Yagasaki; H. Hisakawa; T. Mitsui; A. Manabe; R. Tanaka; K. Kobayashi; M. Ito; K. Yasukawa; T. Nakahata Expansion of human NOD/SCID-repopulating cells by stem cell factor, Flk2/Flt3 ligand, thrombopoietin, IL-6, and soluble IL-6 receptor Expansion of human NOD/SCID-repopulating cells by stem cell factor, Flk2/Flt3 ligand, thrombopoietin, IL-6, and soluble IL-6 receptor ,105,7,1013-1021 2000/04 英語 公開
T. Kimura; J. Wang; H. Minamiguchi; H. Fujiki; S. Harada; K. Okuda; H. Kaneko; S. Yokota; K. Yasukawa; T. Abe; Y. Sonoda T. Kimura; J. Wang; H. Minamiguchi; H. Fujiki; S. Harada; K. Okuda; H. Kaneko; S. Yokota; K. Yasukawa; T. Abe; Y. Sonoda Signal through gp130 activated by soluble interleukin (IL)-6 receptor (R) and IL-6 or IL-6R/IL-6 fusion protein enhances ex vivo expansion of human peripheral blood-derived hematopoietic progenitors Signal through gp130 activated by soluble interleukin (IL)-6 receptor (R) and IL-6 or IL-6R/IL-6 fusion protein enhances ex vivo expansion of human peripheral blood-derived hematopoietic progenitors ,18,6,444-452 2000 英語 公開
X. Sui; K. Tsuji; Y. Ebihara; R. Tanaka; K. Muraoka; M. Yoshida; K. Yamada; K. Yasukawa; T. Taga; T. Kishimoto; T. Nakahata X. Sui; K. Tsuji; Y. Ebihara; R. Tanaka; K. Muraoka; M. Yoshida; K. Yamada; K. Yasukawa; T. Taga; T. Kishimoto; T. Nakahata Soluble interleukin-6 (IL-6) receptor with IL-6 stimulates megakaryopoiesis from human CD34<sup>+</sup> cells through glycoprotein (gp)130 signaling Soluble interleukin-6 (IL-6) receptor with IL-6 stimulates megakaryopoiesis from human CD34<sup>+</sup> cells through glycoprotein (gp)130 signaling ,93,8,2525-2532 1999/04/15 英語 公開
T. Hada; M. Kondo; K. Yasukawa; Y. Amuro; K. Higashino T. Hada; M. Kondo; K. Yasukawa; Y. Amuro; K. Higashino Discrimination of liver cirrhosis from chronic hepatitis by measuring the ratio of Aleuria aurantia lectin-reactive serum cholinesterase to immunoreactive protein Discrimination of liver cirrhosis from chronic hepatitis by measuring the ratio of Aleuria aurantia lectin-reactive serum cholinesterase to immunoreactive protein ,281,1-2,37-46 1999/03 英語 公開
R.L. Moritz; L.D. Ward; G.-F. Tu; L.J. Fabri; H. Ji; K. Yasukawa; R.J. Simpson R.L. Moritz; L.D. Ward; G.-F. Tu; L.J. Fabri; H. Ji; K. Yasukawa; R.J. Simpson The N-terminus of gp130 is critical for the formation of the high-affinity interleukin-6 receptor complex The N-terminus of gp130 is critical for the formation of the high-affinity interleukin-6 receptor complex ,16,4,265-278 1999 英語 公開
C. Song; G. Kenis; A. Van Gastel; E. Bosmans; A. Lin; R. De Jong; H. Neels; S. Scharpé; A. Janca; K. Yasukawa; M. Maes C. Song; G. Kenis; A. Van Gastel; E. Bosmans; A. Lin; R. De Jong; H. Neels; S. Scharpé; A. Janca; K. Yasukawa; M. Maes Influence of psychological stress on immune-inflammatory variables in normal humans. Part II. Altered serum concentrations of natural anti- inflammatory agents and soluble membrane antigens of monocytes and T lymphocytes Influence of psychological stress on immune-inflammatory variables in normal humans. Part II. Altered serum concentrations of natural anti- inflammatory agents and soluble membrane antigens of monocytes and T lymphocytes ,85,3,293-303 1999 英語 公開
J.-G. Zhang; Y. Zhang; C.M. Owczarek; L.D. Ward; R.L. Moritz; R.J. Simpson; K. Yasukawa; N.A. Nicola J.-G. Zhang; Y. Zhang; C.M. Owczarek; L.D. Ward; R.L. Moritz; R.J. Simpson; K. Yasukawa; N.A. Nicola Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor α-chain in normal human urine and plasma Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor α-chain in normal human urine and plasma ,273,17,10798-10805 1998/04/24 英語 公開
Nishida, S; Okimoto, N; Okazaki, Y; Yamaguchi, A; Kumegawa, M; Yasukawa, K; Murayama, K; Nakamura, T Nishida, S; Okimoto, N; Okazaki, Y; Yamaguchi, A; Kumegawa, M; Yasukawa, K; Murayama, K; Nakamura, T Effect of monoclonal anti-human GP130 antibody (GPX7) on bone turnover in normal and ovariectomized rats Effect of monoclonal anti-human GP130 antibody (GPX7) on bone turnover in normal and ovariectomized rats ,62,3,227-236 1998/03 英語 公開
R. Nishimura; K. Moriyama; K. Yasukawa; G.R. Mundy; T. Yoneda R. Nishimura; K. Moriyama; K. Yasukawa; G.R. Mundy; T. Yoneda Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells ,13,5,777-785 1998 英語 公開
T. Kimura; H. Sakabe; S. Tanimukai; T. Abe; Y. Urata; K. Yasukawa; A. Okano; T. Taga; H. Sugiyama; T. Kishimoto; Y. Sonoda T. Kimura; H. Sakabe; S. Tanimukai; T. Abe; Y. Urata; K. Yasukawa; A. Okano; T. Taga; H. Sugiyama; T. Kishimoto; Y. Sonoda Simultaneous activation of signals through gp130, c-kit, and interleukin-3 receptor promotes a trilineage blood cell production in the absence of terminally acting lineage-specific factors Simultaneous activation of signals through gp130, c-kit, and interleukin-3 receptor promotes a trilineage blood cell production in the absence of terminally acting lineage-specific factors ,90,12,4767-4778 1997/12/15 英語 公開
M. Okamoto; K. Yasukawa; K. Katsuura; M. Baba M. Okamoto; K. Yasukawa; K. Katsuura; M. Baba Inhibition of interleukin-6-induced human immunodeficiency virus type 1 expression by anti-gp130 monoclonal antibody Inhibition of interleukin-6-induced human immunodeficiency virus type 1 expression by anti-gp130 monoclonal antibody ,43,4,733-740 1997/11 英語 公開
T. Matsuba; M. Yano; N. Abiru; H. Takino; S. Akazawa; S. Nagataki; K. Yasukawa T. Matsuba; M. Yano; N. Abiru; H. Takino; S. Akazawa; S. Nagataki; K. Yasukawa Expression of recombinant human glutamic acid decarboxylase (GAD) in myeloma cells and enzyme-linked immunosorbent assay (ELISA) for autoantibodies to GAD Expression of recombinant human glutamic acid decarboxylase (GAD) in myeloma cells and enzyme-linked immunosorbent assay (ELISA) for autoantibodies to GAD ,121,1,20-24 1997/01 英語 公開
Y. Nakajima; O. Mikami; M. Yoshioka; Y. Motoi; T. Ito; Y. Ishikawa; M. Fuse; K. Nakano; K. Yasukawa Y. Nakajima; O. Mikami; M. Yoshioka; Y. Motoi; T. Ito; Y. Ishikawa; M. Fuse; K. Nakano; K. Yasukawa Elevated levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) activities in the sera and milk of cows with naturally occurring coliform mastitis Elevated levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) activities in the sera and milk of cows with naturally occurring coliform mastitis ,62,3,297-298 1997 英語 公開
F.A. Montero-Julian; H. Brailly; C. Sautès; I. Joyeux; T. Dorval; V. Mosseri; K. Yasukawa; J. Wijdenes; A. Adler; I. Gorin; W.H. Fridman; E. Tartour F.A. Montero-Julian; H. Brailly; C. Sautès; I. Joyeux; T. Dorval; V. Mosseri; K. Yasukawa; J. Wijdenes; A. Adler; I. Gorin; W.H. Fridman; E. Tartour Characterization of soluble gp130 released by melanoma cell lines: A polyvalent antagonist of cytokines from the interleukin 6 family Characterization of soluble gp130 released by melanoma cell lines: A polyvalent antagonist of cytokines from the interleukin 6 family ,3,8,1443-1451 1997 英語 公開
P. Vollmer; M. Peters; M. Ehlers; H. Yagame; T. Matsuba; M. Kondo; K. Yasukawa; K.-H. Meyer Zum Büschenfelde; S. Rose-John P. Vollmer; M. Peters; M. Ehlers; H. Yagame; T. Matsuba; M. Kondo; K. Yasukawa; K.-H. Meyer Zum Büschenfelde; S. Rose-John Yeast expression of the cytokine receptor domain of the soluble interleukin-6 receptor Yeast expression of the cytokine receptor domain of the soluble interleukin-6 receptor ,199,1,47-54 1996/11/29 英語 公開
T. Taya; K. Yasukawa; K. Miyata; S.-I. Kidokoro; K. Inouye T. Taya; K. Yasukawa; K. Miyata; S.-I. Kidokoro; K. Inouye Genetically engineered antibodies which have reduced binding affinity for thyroxine but retain the same affinity for tri-iodothyronine Genetically engineered antibodies which have reduced binding affinity for thyroxine but retain the same affinity for tri-iodothyronine ,18,11,1325-1330 1996/11 英語 公開
S. Tajima; K. Tsuji; Y. Ebihara; X. Sui; R. Tanaka; K. Muraoka; M. Yoshida; K. Yamada; K. Yasukawa; T. Taga; T. Kishimoto; T. Nakahata S. Tajima; K. Tsuji; Y. Ebihara; X. Sui; R. Tanaka; K. Muraoka; M. Yoshida; K. Yamada; K. Yasukawa; T. Taga; T. Kishimoto; T. Nakahata Analysis on interleukin 6 receptor and gp130 expressions and proliferative capability of human CD34<sup>+</sup> cells Analysis on interleukin 6 receptor and gp130 expressions and proliferative capability of human CD34<sup>+</sup> cells ,184,4,1357-1364 1996/10/01 英語 公開
T. Azuma; M. Hirai; S. Ito; K. Yamamoto; R.T. Taggart; T. Matsuba; K. Yasukawa; K. Uno; T. Hayakumo; M. Nakajima T. Azuma; M. Hirai; S. Ito; K. Yamamoto; R.T. Taggart; T. Matsuba; K. Yasukawa; K. Uno; T. Hayakumo; M. Nakajima Expression of cathepsin E in pancreas: A possible tumor marker for pancreas, a preliminary report Expression of cathepsin E in pancreas: A possible tumor marker for pancreas, a preliminary report ,67,4,492-497 1996/08/07 英語 公開
M. Kondo; T. Taya; T. Matsuba; N. Fushimi; K. Inouye; I. Kidokoro S.-; K. Yasukawa M. Kondo; T. Taya; T. Matsuba; N. Fushimi; K. Inouye; I. Kidokoro S.-; K. Yasukawa Use of a surface plasmon resonance biosensor for the determination of binding constants of transiently expressed recombinant antibody to its antigen Use of a surface plasmon resonance biosensor for the determination of binding constants of transiently expressed recombinant antibody to its antigen ,10,8,547-552 1996/08 英語 公開
K. Ikeda; M. Kinoshita; N. Tagaya; T. Shiojima; T. Taga; K. Yasukawa; H. Suzuki; A. Okano K. Ikeda; M. Kinoshita; N. Tagaya; T. Shiojima; T. Taga; K. Yasukawa; H. Suzuki; A. Okano Coadministration of interleukin-6 (IL-6) and soluble IL-6 receptor delays progression of wobbler mouse motor neuron disease Coadministration of interleukin-6 (IL-6) and soluble IL-6 receptor delays progression of wobbler mouse motor neuron disease ,726,1-2,91-97 1996/07/08 英語 公開
M. Diamant; M.B. Hansen; K. Rieneck; M. Svenson; K. Yasukawa; K. Bendtzen M. Diamant; M.B. Hansen; K. Rieneck; M. Svenson; K. Yasukawa; K. Bendtzen Differential interleukin-6 (IL-6) responses of three established myeloma cell lines in the presence of soluble human IL-6 receptors Differential interleukin-6 (IL-6) responses of three established myeloma cell lines in the presence of soluble human IL-6 receptors ,20,4,291-301 1996/04 英語 公開
X. Sui; K. Tsuji; S. Tajima; R. Tanaka; K. Muraoka; Y. Ebihara; K. Ikebuchi; K. Yasukawa; T. Taga; T. Kishimoto; T. Nakahata X. Sui; K. Tsuji; S. Tajima; R. Tanaka; K. Muraoka; Y. Ebihara; K. Ikebuchi; K. Yasukawa; T. Taga; T. Kishimoto; T. Nakahata Erythropoietin-independent erythrocyte production: Signals through gp130 and c-kit dramatically promote erythropoiesis from human CD34<sup>+</sup> cells Erythropoietin-independent erythrocyte production: Signals through gp130 and c-kit dramatically promote erythropoiesis from human CD34<sup>+</sup> cells ,183,3,837-845 1996/03/01 英語 公開
M. Kondo; T. Hada; K. Fukui; A. Iwasaki; K. Higashino; K. Yasukawa M. Kondo; T. Hada; K. Fukui; A. Iwasaki; K. Higashino; K. Yasukawa Enzyme-linked immunosorbent assay (ELISA) for Aleuria aurantia lectin-reactive serum cholinesterase to differentiate liver cirrhosis and chronic hepatitis Enzyme-linked immunosorbent assay (ELISA) for Aleuria aurantia lectin-reactive serum cholinesterase to differentiate liver cirrhosis and chronic hepatitis ,243,1,1-9 1995/12/15 英語 公開
YANG, ZM; LE, SP; CHEN, DB; COTA, J; SIERO, V; YASUKAWA, K; HARPER, MJK YANG, ZM; LE, SP; CHEN, DB; COTA, J; SIERO, V; YASUKAWA, K; HARPER, MJK LEUKEMIA INHIBITORY FACTOR, LIF RECEPTOR, AND GP130 IN THE MOUSE UTERUS DURING EARLY-PREGNANCY LEUKEMIA INHIBITORY FACTOR, LIF RECEPTOR, AND GP130 IN THE MOUSE UTERUS DURING EARLY-PREGNANCY ,42,4,407-414 1995/12 英語 公開
T. Matsuba; M. Yamada; H. Suzuki; A. Kanai; O. Isozaki; T. Yoshida; T. Tsushima; K. Yasukawa T. Matsuba; M. Yamada; H. Suzuki; A. Kanai; O. Isozaki; T. Yoshida; T. Tsushima; K. Yasukawa Expression of recombinant human thyrotropin receptor in myeloma cells Expression of recombinant human thyrotropin receptor in myeloma cells ,118,2,265-270 1995/08 英語 公開
F.D. De Hon; E. Ten Boekel; J. Herrman; C. Clement; M. Ehlers; T. Taga; K. Yasukawa; Y. Ohsugi; T. Kishimoto; S. Rose-John; J. Wijdenes; R. Kastelein; L.A. Aarden; J.P.J. Brakenhoff F.D. De Hon; E. Ten Boekel; J. Herrman; C. Clement; M. Ehlers; T. Taga; K. Yasukawa; Y. Ohsugi; T. Kishimoto; S. Rose-John; J. Wijdenes; R. Kastelein; L.A. Aarden; J.P.J. Brakenhoff Functional distinction of two regions of human interleukin 6 important for signal transduction via gp130 Functional distinction of two regions of human interleukin 6 important for signal transduction via gp130 ,7,5,398-407 1995/07 英語 公開
D. Guschin; N. Rogers; J. Briscoe; B. Witthuhn; D. Watling; F. Horn; S. Pellegrini; K. Yasukawa; P. Heinrich; G.R. Stark; J.N. Ihle; I.M. Kerr D. Guschin; N. Rogers; J. Briscoe; B. Witthuhn; D. Watling; F. Horn; S. Pellegrini; K. Yasukawa; P. Heinrich; G.R. Stark; J.N. Ihle; I.M. Kerr A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6 A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6 ,14,7,1421-1429 1995/04/03 英語 公開
L.D. Ward; G.J. Hewlett; A. Hammacher; J. Weinstock; K. Yasukawa; R.J. Simpson; D.J. Winzor L.D. Ward; G.J. Hewlett; A. Hammacher; J. Weinstock; K. Yasukawa; R.J. Simpson; D.J. Winzor Use of a biosensor with surface plasmon resonance detection for the determination of binding constants: Measurement of interleukin-6 binding to the soluble interleukin-6 receptor Use of a biosensor with surface plasmon resonance detection for the determination of binding constants: Measurement of interleukin-6 binding to the soluble interleukin-6 receptor ,34,9,2901-2907 1995/03/07 英語 公開
Y. Iba; T. Kaneko; T. Ekida; K. Miyata; K. Inouye; Y. Kurosawa; K. Yasukawa Y. Iba; T. Kaneko; T. Ekida; K. Miyata; K. Inouye; Y. Kurosawa; K. Yasukawa A new system for the expression of recombinant antibody in mammalian cells A new system for the expression of recombinant antibody in mammalian cells ,17,2,135-138 1995/02 英語 公開
M.B. Hansen; M. Svenson; K. Abell; K. Yasukawa; M. Diamant; K. Bendtzen M.B. Hansen; M. Svenson; K. Abell; K. Yasukawa; M. Diamant; K. Bendtzen Influence of interleukin-6 (IL-6) autoantibodies on IL-6 binding to cellular receptors Influence of interleukin-6 (IL-6) autoantibodies on IL-6 binding to cellular receptors ,25,2,348-354 1995/02 英語 公開
K. Takagi; K. Yasukawa; Y. Iba; Y. Isobe; Y. Suketa; R. Kannagi; K. Kohda; M. Takagi; T. Imanaka K. Takagi; K. Yasukawa; Y. Iba; Y. Isobe; Y. Suketa; R. Kannagi; K. Kohda; M. Takagi; T. Imanaka Expression of recombinant antibody against cancer-specific carbohydrate Expression of recombinant antibody against cancer-specific carbohydrate ,79,5,405-409 1995 英語 公開
L.D. Ward; G.J. Howlett; R.L. Moritz; A. Hammacher; K. Yasukawa; R.J. Simpson L.D. Ward; G.J. Howlett; R.L. Moritz; A. Hammacher; K. Yasukawa; R.J. Simpson Studies of cytokine-cytokine receptor interactions: Influence of ligand dimerization Studies of cytokine-cytokine receptor interactions: Influence of ligand dimerization ,6,C,417-425 1995 英語 公開
A. Hammacher; L.D. Ward; J. Weinstock; H. Treutlein; K. Yasukawa; R.J. Simpson A. Hammacher; L.D. Ward; J. Weinstock; H. Treutlein; K. Yasukawa; R.J. Simpson Structure-function analysis of human IL-6: Identification of two distinct regions that are important for receptor binding Structure-function analysis of human IL-6: Identification of two distinct regions that are important for receptor binding ,3,12,2280-2293 1994/12 英語 公開
L.D. Ward; G.J. Howlett; G. Discolo; K. Yasukawa; A. Hammacher; R.L. Moritz; R.J. Simpson L.D. Ward; G.J. Howlett; G. Discolo; K. Yasukawa; A. Hammacher; R.L. Moritz; R.J. Simpson High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130 High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130 ,269,37,23286-23289 1994/09/16 英語 公開
M. Diamant; M.B. Hansen; K. Rieneck; M. Svenson; K. Yasukawa; K. Bendtzen M. Diamant; M.B. Hansen; K. Rieneck; M. Svenson; K. Yasukawa; K. Bendtzen Stimulation of the B9 hybridoma cell line by soluble interleukin-6 receptors Stimulation of the B9 hybridoma cell line by soluble interleukin-6 receptors ,173,2,229-235 1994/08/01 英語 公開
E. Dittrich; S. Rose-John; C. Gerhartz; J. Müllberg; T. Stoyan; K. Yasukawa; P.C. Heinrich; L. Graeve E. Dittrich; S. Rose-John; C. Gerhartz; J. Müllberg; T. Stoyan; K. Yasukawa; P.C. Heinrich; L. Graeve Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor ,269,29,19014-19020 1994/07/22 英語 公開
Z.-Y. Lu; X.-G. Zhang; Z.-J. Gu; K. Yasukawa; M. Amiot; M. Etrilland; R. Bataille; B. Klein Z.-Y. Lu; X.-G. Zhang; Z.-J. Gu; K. Yasukawa; M. Amiot; M. Etrilland; R. Bataille; B. Klein A highly sensitive quantitative bioassay for human interleukin-11 A highly sensitive quantitative bioassay for human interleukin-11 ,173,1,19-26 1994/07/12 英語 公開
C. Gerhartz; E. Dittrich; T. Stoyan; S. Rose-John; K. Yasukawa; P.C. Heinrich; L. Graeve C. Gerhartz; E. Dittrich; T. Stoyan; S. Rose-John; K. Yasukawa; P.C. Heinrich; L. Graeve Biosynthesis and half-life of the interleukin-6 receptor and its signal transducer gp130 Biosynthesis and half-life of the interleukin-6 receptor and its signal transducer gp130 ,223,1,265-274 1994/07/01 英語 公開
YIN, TG; YASUKAWA, K; TAGA, T; KISHIMOTO, T; YANG, YC YIN, TG; YASUKAWA, K; TAGA, T; KISHIMOTO, T; YANG, YC IDENTIFICATION OF A 130-KILODALTON TYROSINE-PHOSPHORYLATED PROTEIN-INDUCED BY INTERLEUKIN-11 AS JAK2 TYROSINE KINASE, WHICH ASSOCIATES WITH GP130 SIGNAL TRANSDUCER IDENTIFICATION OF A 130-KILODALTON TYROSINE-PHOSPHORYLATED PROTEIN-INDUCED BY INTERLEUKIN-11 AS JAK2 TYROSINE KINASE, WHICH ASSOCIATES WITH GP130 SIGNAL TRANSDUCER ,22,5,467-472 1994/05 英語 公開
X.-G. Zhang; J.-J. Gu; Z.-Y. Lu; K. Yasukawa; G.D. Yancopoulos; K. Turner; M. Shoyab; T. Taga; T. Kishimoto; R. Bataille; B. Klein X.-G. Zhang; J.-J. Gu; Z.-Y. Lu; K. Yasukawa; G.D. Yancopoulos; K. Turner; M. Shoyab; T. Taga; T. Kishimoto; R. Bataille; B. Klein Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer GP130 Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer GP130 ,179,4,1337-1342 1994/04/01 英語 公開
TAKAGI, K; ISOBE, Y; YASUKAWA, K; OKOUCHI, E; SUKETA, Y TAKAGI, K; ISOBE, Y; YASUKAWA, K; OKOUCHI, E; SUKETA, Y NITRIC-OXIDE BLOCKS THE CELL-CYCLE OF MOUSE MACROPHAGE-LIKE CELLS IN THE EARLY G(2)+M PHASE NITRIC-OXIDE BLOCKS THE CELL-CYCLE OF MOUSE MACROPHAGE-LIKE CELLS IN THE EARLY G(2)+M PHASE ,340,3,159-162 1994/03/07 英語 公開
K. Yoshida; I. Chambers; J. Nichols; A. Smith; M. Saito; K. Yasukawa; M. Shoyab; T. Taga; T. Kishimoto K. Yoshida; I. Chambers; J. Nichols; A. Smith; M. Saito; K. Yasukawa; M. Shoyab; T. Taga; T. Kishimoto Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways ,45,2,163-171 1994/02 英語 公開
C. Lutticken; U.M. Wegenka; J. Yuan; J. Buschmann; C. Schindler; A. Ziemiecki; A.G. Harpur; A.F. Wilks; K. Yasukawa; T. Taga; T. Kishimoto; G. Barbieri; S. Pellegrini; M. Sendtner; P.C. Heinrich; F. Horn C. Lutticken; U.M. Wegenka; J. Yuan; J. Buschmann; C. Schindler; A. Ziemiecki; A.G. Harpur; A.F. Wilks; K. Yasukawa; T. Taga; T. Kishimoto; G. Barbieri; S. Pellegrini; M. Sendtner; P.C. Heinrich; F. Horn Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130 Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130 ,263,5143,89-92 1994/01/07 英語 公開
YIN, TG; TAGA, T; TSANG, MLS; YASUKAWA, K; KISHIMOTO, T; YANG, YC YIN, TG; TAGA, T; TSANG, MLS; YASUKAWA, K; KISHIMOTO, T; YANG, YC INVOLVEMENT OF IL-6 SIGNAL TRANSDUCER GP130 IN IL-11-MEDIATED SIGNAL-TRANSDUCTION INVOLVEMENT OF IL-6 SIGNAL TRANSDUCER GP130 IN IL-11-MEDIATED SIGNAL-TRANSDUCTION ,151,5,2555-2561 1993/09/01 英語 公開
L.D. Ward; A. Hammacher; J.-G. Zhang; J. Weinstock; K. Yasukawa; C.J. Morton; R.S. Norton; R.J. Simpson L.D. Ward; A. Hammacher; J.-G. Zhang; J. Weinstock; K. Yasukawa; C.J. Morton; R.S. Norton; R.J. Simpson Role of the C-terminus in the activity, conformation, and stability of interleukin-6 Role of the C-terminus in the activity, conformation, and stability of interleukin-6 ,2,9,1472-1481 1993/09 英語 公開
M. Narazaki; K. Yasukawa; T. Saito; Y. Ohsugi; H. Fukui; Y. Koishihara; G.D. Yancopoulos; T. Taga; T. Kishimoto M. Narazaki; K. Yasukawa; T. Saito; Y. Ohsugi; H. Fukui; Y. Koishihara; G.D. Yancopoulos; T. Taga; T. Kishimoto Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130 Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130 ,82,4,1120-1126 1993/08/15 英語 公開
SAITO, T; TAGA, T; MIKI, D; FUTATSUGI, K; YAWATA, H; KISHIMOTO, T; YASUKAWA, K SAITO, T; TAGA, T; MIKI, D; FUTATSUGI, K; YAWATA, H; KISHIMOTO, T; YASUKAWA, K PREPARATION OF MONOCLONAL-ANTIBODIES AGAINST THE IL-6 SIGNAL TRANSDUCER, GP130, THAT CAN INHIBIT IL-6-MEDIATED FUNCTIONS PREPARATION OF MONOCLONAL-ANTIBODIES AGAINST THE IL-6 SIGNAL TRANSDUCER, GP130, THAT CAN INHIBIT IL-6-MEDIATED FUNCTIONS ,163,2,217-223 1993/08/09 英語 公開
M. Murakami; M. Hibi; N. Nakagawa; T. Nakagawa; K. Yasukawa; K. Yamanishi; T. Taga; T. Kishimoto M. Murakami; M. Hibi; N. Nakagawa; T. Nakagawa; K. Yasukawa; K. Yamanishi; T. Taga; T. Kishimoto IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase ,260,5115,1808-1810 1993/06/18 英語 公開
H. Yawata; K. Yasukawa; S. Natsuka; M. Murakami; K. Yamasaki; M. Hibi; T. Taga; T. Kishimoto H. Yawata; K. Yasukawa; S. Natsuka; M. Murakami; K. Yamasaki; M. Hibi; T. Taga; T. Kishimoto Structure - Function analysis of human IL-6 receptor: Dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130 Structure - Function analysis of human IL-6 receptor: Dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130 ,12,4,1705-1712 1993/04 英語 公開
J.-P. Gaillard; R. Bataille; H. Brailly; C. Zuber; K. Yasukawa; M. Attal; N. Maruo; T. Taga; T. Kishimoto; B. Klein J.-P. Gaillard; R. Bataille; H. Brailly; C. Zuber; K. Yasukawa; M. Attal; N. Maruo; T. Taga; T. Kishimoto; B. Klein Increased and highly stable levels of functional soluble interleukin-6 receptor in sera of patients with monoclonal gammopathy Increased and highly stable levels of functional soluble interleukin-6 receptor in sera of patients with monoclonal gammopathy ,23,4,820-824 1993/04 英語 公開
Y. Nakajima; E. Momotani; T. Murakami; Y. Ishikawa; M. Morimatsu; M. Saito; H. Suzuki; K. Yasukawa Y. Nakajima; E. Momotani; T. Murakami; Y. Ishikawa; M. Morimatsu; M. Saito; H. Suzuki; K. Yasukawa Induction of acute phase protein by recombinant human interleukin-6 (IL-6) in calves Induction of acute phase protein by recombinant human interleukin-6 (IL-6) in calves ,35,3-4,385-391 1993/01 英語 公開
T. Kaneko; Y. Iba; K. Zenita; K. Shigeta; K. Nakano; W. Itoh; Y. Kurosawa; R. Kannagi; K. Yasukawa T. Kaneko; Y. Iba; K. Zenita; K. Shigeta; K. Nakano; W. Itoh; Y. Kurosawa; R. Kannagi; K. Yasukawa Preparation of mouse-human chimeric antibody to an embryonic carbohydrate antigen, Lewis Y Preparation of mouse-human chimeric antibody to an embryonic carbohydrate antigen, Lewis Y ,113,1,114-117 1993/01 英語 公開
H. Suzuki; K. Yasukawa; T. Saito; M. Narazaki; A. Hasegawa; T. Taga; T. Kishimoto H. Suzuki; K. Yasukawa; T. Saito; M. Narazaki; A. Hasegawa; T. Taga; T. Kishimoto Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal ,23,5,1078-1082 1993 英語 公開
J. Müllberg; E. Dittrich; L. Graeve; C. Gerhartz; K. Yasukawa; T. Taga; T. Kishimoto; P.C. Heinrich; S. Rose-John J. Müllberg; E. Dittrich; L. Graeve; C. Gerhartz; K. Yasukawa; T. Taga; T. Kishimoto; P.C. Heinrich; S. Rose-John Differential shedding of the two subunits of the interleukin-6 receptor Differential shedding of the two subunits of the interleukin-6 receptor ,332,1-2,174-178 1993 英語 公開
I. Kobayashi; T. Matsuda; T. Saito; K. Yasukawa; H. Kikutani; T. Hirano; T. Taga; T. Kishimoto I. Kobayashi; T. Matsuda; T. Saito; K. Yasukawa; H. Kikutani; T. Hirano; T. Taga; T. Kishimoto Abnormal distribution of IL-6 receptor in aged MRL/lpr mice: Elevated expression on B cells and absence on CD4<sup>+</sup> cells Abnormal distribution of IL-6 receptor in aged MRL/lpr mice: Elevated expression on B cells and absence on CD4<sup>+</sup> cells ,4,12,1407-1412 1992/12 英語 公開
M. Yamaguchi; M. Michishita; K. Hirayoshi; K. Yasukawa; M. Okuma; K. Nagata M. Yamaguchi; M. Michishita; K. Hirayoshi; K. Yasukawa; M. Okuma; K. Nagata Down-regulation of interleukin 6 receptors of mouse myelomonocytic leukemic cells by leukemia inhibitory factor Down-regulation of interleukin 6 receptors of mouse myelomonocytic leukemic cells by leukemia inhibitory factor ,267,31,22035-22042 1992/11/05 英語 公開
NISHIMURA, C; EKIDA, T; NOMURA, K; SAKAMOTO, K; SUZUKI, H; YASUKAWA, K; KISHIMOTO, T; ARATA, Y NISHIMURA, C; EKIDA, T; NOMURA, K; SAKAMOTO, K; SUZUKI, H; YASUKAWA, K; KISHIMOTO, T; ARATA, Y ROLE OF LEUCINE RESIDUES IN THE C-TERMINAL REGION OF HUMAN INTERLEUKIN-6 IN THE BIOLOGICAL-ACTIVITY ROLE OF LEUCINE RESIDUES IN THE C-TERMINAL REGION OF HUMAN INTERLEUKIN-6 IN THE BIOLOGICAL-ACTIVITY ,311,3,271-275 1992/10/26 英語 公開
J. Liu; B. Modrell; A. Aruffo; J.S. Marken; T. Taga; K. Yasukawa; M. Murakami; T. Kishimoto; M. Shoyab J. Liu; B. Modrell; A. Aruffo; J.S. Marken; T. Taga; K. Yasukawa; M. Murakami; T. Kishimoto; M. Shoyab Interleukin-6 signal transducer gp130 mediates oncostatin M signaling Interleukin-6 signal transducer gp130 mediates oncostatin M signaling ,267,24,16763-16766 1992/08/25 英語 公開
H. Suzuki; K. Yasukawa; T. Saito; R. Goitsuka; A. Hasegawa; Y. Ohsugi; T. Taga; T. Kishimoto H. Suzuki; K. Yasukawa; T. Saito; R. Goitsuka; A. Hasegawa; Y. Ohsugi; T. Taga; T. Kishimoto Anti-human interleukin-6 receptor antibody inhibits human myeloma growth in vivo Anti-human interleukin-6 receptor antibody inhibits human myeloma growth in vivo ,22,8,1989-1993 1992/08 英語 公開
T. Saito; K. Futatsugi; D. Miki; H. Suzuki; K. Yasukawa T. Saito; K. Futatsugi; D. Miki; H. Suzuki; K. Yasukawa An establishment of ELISA for murine IL-6 An establishment of ELISA for murine IL-6 ,6,4,365-370 1992/07 英語 公開
NOMOTO, H; YASUKAWA, K; INOUE, Y NOMOTO, H; YASUKAWA, K; INOUE, Y SEPARATION OF NEUTRAL GLYCOASPARAGINES ACCORDING TO THEIR CONTENT OF CIS DIOL GROUPS SEPARATION OF NEUTRAL GLYCOASPARAGINES ACCORDING TO THEIR CONTENT OF CIS DIOL GROUPS ,56,7,1090-1095 1992/07 英語 公開
N.Y. Ip; S.H. Nye; T.G. Boulton; S. Davis; T. Taga; Y. Li; S.J. Birren; K. Yasukawa; T. Kishimoto; D.J. Anderson; N. Stahl; G.D. Yancopoulos N.Y. Ip; S.H. Nye; T.G. Boulton; S. Davis; T. Taga; Y. Li; S.J. Birren; K. Yasukawa; T. Kishimoto; D.J. Anderson; N. Stahl; G.D. Yancopoulos CNTF and LIF Act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130 CNTF and LIF Act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130 ,69,7,1121-1132 1992/06/26 英語 公開
HONDA, M; YAMAMOTO, S; CHENG, M; YASUKAWA, K; SUZUKI, H; SAITO, T; OSUGI, Y; TOKUNAGA, T; KISHIMOTO, T HONDA, M; YAMAMOTO, S; CHENG, M; YASUKAWA, K; SUZUKI, H; SAITO, T; OSUGI, Y; TOKUNAGA, T; KISHIMOTO, T HUMAN SOLUBLE IL-6 RECEPTOR - ITS DETECTION AND ENHANCED RELEASE BY HIV-INFECTION HUMAN SOLUBLE IL-6 RECEPTOR - ITS DETECTION AND ENHANCED RELEASE BY HIV-INFECTION ,148,7,2175-2180 1992/04/01 英語 公開
NAKAJIMA, T; YAMAMOTO, S; CHENG, M; YASUKAWA, K; HIRANO, T; KISHIMOTO, T; TOKUNAGA, T; HONDA, M NAKAJIMA, T; YAMAMOTO, S; CHENG, M; YASUKAWA, K; HIRANO, T; KISHIMOTO, T; TOKUNAGA, T; HONDA, M SOLUBLE INTERLEUKIN-6 RECEPTOR IS RELEASED FROM RECEPTOR-BEARING CELL-LINES INVITRO SOLUBLE INTERLEUKIN-6 RECEPTOR IS RELEASED FROM RECEPTOR-BEARING CELL-LINES INVITRO ,83,4,373-378 1992/04 英語 公開
K. Yasukawa; K. Futatsugi; T. Saito; H. Yawata; M. Narazaki; H. Suzuki; T. Taga; T. Kishimoto K. Yasukawa; K. Futatsugi; T. Saito; H. Yawata; M. Narazaki; H. Suzuki; T. Taga; T. Kishimoto Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130 Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130 ,31,2,123-130 1992/02/01 英語 公開
T. Taga; M. Hibi; M. Murakami; M. Saito; H. Yawata; M. Narazaki; Y. Hirata; T. Sugita; K. Yasukawa; T. Hirano; T. Kishimoto T. Taga; M. Hibi; M. Murakami; M. Saito; H. Yawata; M. Narazaki; Y. Hirata; T. Sugita; K. Yasukawa; T. Hirano; T. Kishimoto Interleukin-6 receptor and signals Interleukin-6 receptor and signals ,51,181-204 1992 英語 公開
MIHARA, M; KOISHIHARA, Y; FUKUI, H; YASUKAWA, K; OHSUGI, Y MIHARA, M; KOISHIHARA, Y; FUKUI, H; YASUKAWA, K; OHSUGI, Y MURINE ANTI-HUMAN IL-6 MONOCLONAL-ANTIBODY PROLONGS THE HALF-LIFE IN CIRCULATING BLOOD AND THUS PROLONGS THE BIOACTIVITY OF HUMAN IL-6 IN MICE MURINE ANTI-HUMAN IL-6 MONOCLONAL-ANTIBODY PROLONGS THE HALF-LIFE IN CIRCULATING BLOOD AND THUS PROLONGS THE BIOACTIVITY OF HUMAN IL-6 IN MICE ,74,1,55-59 1991/09 英語 公開
H. Suzuki; K. Yasukawa; T. Saito; M. Anzai; R. Goitsuka; A. Hasegawa; Y. Ohsugi; T. Taga; T. Kishimoto H. Suzuki; K. Yasukawa; T. Saito; M. Anzai; R. Goitsuka; A. Hasegawa; Y. Ohsugi; T. Taga; T. Kishimoto Anti-murine IL-6 receptor antibody inhibits IL-6 effects in vivo Anti-murine IL-6 receptor antibody inhibits IL-6 effects in vivo ,30,1,17-22 1991/09 英語 公開
T. Saito; K. Yasukawa; H. Suzuki; K. Futatsugi; T. Fukunaga; C. Yokomizo; Y. Koishihara; H. Fukui; Y. Ohsugi; H. Yawata; I. Kobayashi; T. Hirano; T. Taga; T. Kishimoto T. Saito; K. Yasukawa; H. Suzuki; K. Futatsugi; T. Fukunaga; C. Yokomizo; Y. Koishihara; H. Fukui; Y. Ohsugi; H. Yawata; I. Kobayashi; T. Hirano; T. Taga; T. Kishimoto Preparation of soluble murine IL-6 receptor and anti-murine IL-6 receptor antibodies Preparation of soluble murine IL-6 receptor and anti-murine IL-6 receptor antibodies ,147,1,168-173 1991/07/01 英語 公開
K. Hirayoshi; A. Tsuru; M. Yamashita; M. Tomida; Y. Yamamoto-Yamaguchi; K. Yasukawa; M. Hozumi; D.V. Goeddel; K. Nagata K. Hirayoshi; A. Tsuru; M. Yamashita; M. Tomida; Y. Yamamoto-Yamaguchi; K. Yasukawa; M. Hozumi; D.V. Goeddel; K. Nagata Both D factor/LIF and IL-6 inhibit the differentation of mouse teratocarcinoma F9 cells Both D factor/LIF and IL-6 inhibit the differentation of mouse teratocarcinoma F9 cells ,282,2,401-404 1991/05/06 英語 公開
NISHIMURA, C; FUTATSUGI, K; YASUKAWA, K; KISHIMOTO, T; ARATA, Y NISHIMURA, C; FUTATSUGI, K; YASUKAWA, K; KISHIMOTO, T; ARATA, Y SITE-SPECIFIC MUTAGENESIS OF HUMAN INTERLEUKIN-6 AND ITS BIOLOGICAL-ACTIVITY SITE-SPECIFIC MUTAGENESIS OF HUMAN INTERLEUKIN-6 AND ITS BIOLOGICAL-ACTIVITY ,281,1-2,167-169 1991/04/09 英語 公開
NISHIMURA, C; EKIDA, T; MASUDA, S; FUTATSUGI, K; ITOH, S; YASUKAWA, K; KISHIMOTO, T; ARATA, Y NISHIMURA, C; EKIDA, T; MASUDA, S; FUTATSUGI, K; ITOH, S; YASUKAWA, K; KISHIMOTO, T; ARATA, Y CHEMICAL MODIFICATION AND H-1-NMR STUDIES ON THE RECEPTOR-BINDING REGION OF HUMAN INTERLEUKIN-6 CHEMICAL MODIFICATION AND H-1-NMR STUDIES ON THE RECEPTOR-BINDING REGION OF HUMAN INTERLEUKIN-6 ,196,2,377-384 1991/03/14 英語 公開
NISHIMURA, C; HANZAWA, H; ITOH, S; YASUKAWA, K; SHIMADA, I; KISHIMOTO, T; ARATA, Y NISHIMURA, C; HANZAWA, H; ITOH, S; YASUKAWA, K; SHIMADA, I; KISHIMOTO, T; ARATA, Y PROTON NUCLEAR-MAGNETIC-RESONANCE STUDY OF HUMAN INTERLEUKIN-6 - CHEMICAL MODIFICATIONS AND PARTIAL SPECTRAL ASSIGNMENTS FOR THE AROMATIC RESIDUES PROTON NUCLEAR-MAGNETIC-RESONANCE STUDY OF HUMAN INTERLEUKIN-6 - CHEMICAL MODIFICATIONS AND PARTIAL SPECTRAL ASSIGNMENTS FOR THE AROMATIC RESIDUES ,1041,3,243-249 1990/12/05 英語 公開
K. Yasukawa; T. Saito; T. Fukunaga; Y. Sekimori; Y. Koishihara; H. Fukui; Y. Ohsugi; T. Matsuda; H. Yawata; T. Hirano; T. Taga; T. Kishimoto K. Yasukawa; T. Saito; T. Fukunaga; Y. Sekimori; Y. Koishihara; H. Fukui; Y. Ohsugi; T. Matsuda; H. Yawata; T. Hirano; T. Taga; T. Kishimoto Purification and characterization of soluble human IL-6 receptor expressed in CHO cells Purification and characterization of soluble human IL-6 receptor expressed in CHO cells ,108,4,673-676 1990/10 英語 公開
K. Yasukawa; T. Saito K. Yasukawa; T. Saito A new system for the expression of human interleukin-6 in Eschrichia coli A new system for the expression of human interleukin-6 in Eschrichia coli ,12,6,419-424 1990/06 英語 公開
GOITSUKA, R; OHASHI, T; ONO, K; YASUKAWA, K; KOISHIBARA, Y; FUKUI, H; OHSUGI, Y; HASEGAWA, A GOITSUKA, R; OHASHI, T; ONO, K; YASUKAWA, K; KOISHIBARA, Y; FUKUI, H; OHSUGI, Y; HASEGAWA, A IL-6 ACTIVITY IN FELINE INFECTIOUS PERITONITIS IL-6 ACTIVITY IN FELINE INFECTIOUS PERITONITIS ,144,7,2599-2603 1990/04/01 英語 公開
T. Taga; M. Hibi; Y. Hirata; K. Yamasaki; K. Yasukawa; T. Matsuda; T. Hirano; T. Kishimoto T. Taga; M. Hibi; Y. Hirata; K. Yamasaki; K. Yasukawa; T. Matsuda; T. Hirano; T. Kishimoto Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 ,58,3,573-581 1989/08/11 英語 公開
T. Hirano; T. Taga; K. Yamasaki; T. Matsuda; K. Yasukawa; Y. Hirata; H. Yawata; O. Tanabe; S. Akira; T. Kishimoto T. Hirano; T. Taga; K. Yamasaki; T. Matsuda; K. Yasukawa; Y. Hirata; H. Yawata; O. Tanabe; S. Akira; T. Kishimoto Molecular cloning of the cDNAs for interleukin-6/B cell stimulatory factor 2 and its receptor Molecular cloning of the cDNAs for interleukin-6/B cell stimulatory factor 2 and its receptor ,557,167-180 1989 英語 公開
T. Taga; M. Hibi; Y. Hirata; H. Yawata; S. Natsuka; K. Yasukawa; T. Totsuka; K. Yamasaki; T. Hirano; T. Kishimoto T. Taga; M. Hibi; Y. Hirata; H. Yawata; S. Natsuka; K. Yasukawa; T. Totsuka; K. Yamasaki; T. Hirano; T. Kishimoto Interleukin-6 receptor and a unique mechanism of its signal transduction Interleukin-6 receptor and a unique mechanism of its signal transduction ,54,2,713-722 1989 英語 公開
Y. Asagoe; K. Yasukawa; T. Saito; N. Maruo; K. Miyata; T. Kono; T. Miyake; T. Kato; H. Kakidani; M. Mitani Y. Asagoe; K. Yasukawa; T. Saito; N. Maruo; K. Miyata; T. Kono; T. Miyake; T. Kato; H. Kakidani; M. Mitani Human B-cell stimulatory factor-2 expressed in Escherichia coli Human B-cell stimulatory factor-2 expressed in Escherichia coli ,6,7,806-809 1988 英語 公開
N. Maruo; K. Miyata; K. Yasukawa; T. Fukunaga; M. Mitani N. Maruo; K. Miyata; K. Yasukawa; T. Fukunaga; M. Mitani The production of BSF-2/IL-6 by human glioblastoma The production of BSF-2/IL-6 by human glioblastoma ,10,SUPPL. 1,14- 1988 英語 公開
K. Yasukawa; T. Hirano; Y. Watanabe; K. Muratani; T. Matsuda; S. Nakai; T. Kishimoto K. Yasukawa; T. Hirano; Y. Watanabe; K. Muratani; T. Matsuda; S. Nakai; T. Kishimoto Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene. Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene. ,6,10,2939-2945 1987/10 英語 公開
T. Hirano; K. Yasukawa; H. Harada; T. Taga; Y. Watanabe; T. Matsuda; S. Kashiwamura; K. Nakajima; K. Koyama; A. Iwamatsu T. Hirano; K. Yasukawa; H. Harada; T. Taga; Y. Watanabe; T. Matsuda; S. Kashiwamura; K. Nakajima; K. Koyama; A. Iwamatsu Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin ,324,6092,73-76 1986/11/06 英語 公開
WATANABE, K; YASUKAWA, K; ISO, K WATANABE, K; YASUKAWA, K; ISO, K GRAPHIC DISPLAY OF NUCLEIC-ACID STRUCTURE BY A MICROCOMPUTER GRAPHIC DISPLAY OF NUCLEIC-ACID STRUCTURE BY A MICROCOMPUTER ,12,1,801-809 1984 英語 公開

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賞の名称(日本語) 賞の名称(英語) 授与組織名(日本語) 授与組織名(英語) 年月
日本生物工学会論文賞Excellent Paper Aword of the Society for Biotechnology, Japan 1996
外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
基盤研究(C) 代表 組換えAMV逆転写酵素発現系の構築と蛋白質工学による生産性、活性、熱安定性の向上 2007/04/01〜2009/03/31
基盤研究(C) 代表 高機能逆転写酵素を用いたcDNA合成法とRNA増幅法の性能評価と用途拡大 2009/04/01〜2011/03/31
基盤研究(C) 代表 耐熱型逆転写酵素の耐熱化機構の解明 (平成27年度分) 2015/04/01〜2016/03/31
基盤研究(C) 代表 耐熱型逆転写酵素の耐熱化機構の解明 (平成28年度分) 2016/04/01〜2017/03/31
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
食品基礎生物学Ⅰ Introduction to the Molecular Cell Biology
食品分子生物学 Moelcular Biology of Foods
酵素化学 Enzyme Chemistry
酵素化学・生化学実験及び実験法 Laboratory Course in Enzyme Chemistry and Biochemistry
酵素の作用と応用 後期 農学部 2011/04〜2012/03
食品生化学I 前期 農学部 2011/04〜2012/03
食品生化学Ⅱ 後期 農学部 2011/04〜2012/03
酵素化学 後期 農学部 2011/04〜2012/03
酵素化学・生化学実験及び実験法 前期 農学部 2011/04〜2012/03
酵素化学専攻実験 農学研究科 2011/04〜2012/03
酵素化学専攻演習 農学研究科 2011/04〜2012/03
酵素化学特論 農学研究科 2011/04〜2012/03
酵素の作用と応用 Enzymes: Function and Application 後期 農学部 2012/04〜2013/03
酵素化学 Enzyme Chemistry 後期 農学部 2012/04〜2013/03
酵素化学実験及び実験法 Laboratory Course in Enzyme Chemistry 前期 農学部 2012/04〜2013/03
酵素を用いた高感度分析 Uses of enzymes in sensitive analyses 前期 全学共通科目 2012/04〜2013/03
食品生化学I Food Biochemistry I 前期 農学部 2012/04〜2013/03
食品生化学II Food Biochemistry II 後期 農学部 2012/04〜2013/03
酵素の作用と応用 Enzymes: Function and Application 後期 農学部 2013/04〜2014/03
食品生化学I Food Biochemistry I 前期 農学部 2013/04〜2014/03
食品生化学II Food Biochemistry II 後期 農学部 2013/04〜2014/03
酵素化学 Enzyme Chemistry 後期 農学部 2013/04〜2014/03
酵素化学実験及び実験法 Laboratory Course in Enzyme Chemistry 前期 農学部 2013/04〜2014/03
酵素化学特論 Enzyme Chemistry (Advanced Course) 後期集中 農学研究科 2013/04〜2014/03
酵素化学専攻演習 Enzyme Chemistry Seminar 通年 農学研究科 2013/04〜2014/03
酵素化学専攻実験 Experimental Course of Enzyme Chemistry 通年 農学研究科 2013/04〜2014/03
酵素を用いた高感度分析 Uses of enzymes in sensitive analyses 前期 全学共通科目 2013/04〜2014/03
酵素の作用と応用 Enzymes: Function and Application 後期 農学部 2014/04〜2015/03
食品生化学I Food Biochemistry I 前期 農学部 2014/04〜2015/03
食品生化学II Food Biochemistry II 後期 農学部 2014/04〜2015/03
酵素化学 Enzyme Chemistry 後期 農学部 2014/04〜2015/03
酵素化学実験及び実験法 Laboratory Course in Enzyme Chemistry 前期 農学部 2014/04〜2015/03
食品分析化学 Analytical Chemistry in Food Science 後期 農学部 2014/04〜2015/03
酵素化学専攻演習 Enzyme Chemistry Seminar 通年 農学研究科 2014/04〜2015/03
酵素化学専攻実験 Experimental Course of Enzyme Chemistry 通年 農学研究科 2014/04〜2015/03
酵素の作用と応用 Enzymes: Function and Application 後期 農学部 2015/04〜2016/03
酵素化学 Enzyme Chemistry 後期 農学部 2015/04〜2016/03
酵素化学実験及び実験法 Laboratory Course in Enzyme Chemistry 前期 農学部 2015/04〜2016/03
酵素化学専攻実験1 Experimental Course of Enzyme Chemistry1 通年 農学研究科 2015/04〜2016/03
酵素化学専攻実験 Experimental Course of Enzyme Chemistry 通年 農学研究科 2015/04〜2016/03
酵素化学専攻演習1 Enzyme Chemistry Seminar1 通年 農学研究科 2015/04〜2016/03
酵素化学専攻演習 Enzyme Chemistry Seminar 通年 農学研究科 2015/04〜2016/03
酵素化学特論 Enzyme Chemistry (Advanced Course) 後期集中 農学研究科 2015/04〜2016/03
食品分析化学 Analytical Chemistry in Food Science 後期 農学部 2015/04〜2016/03
食品生化学I Food Biochemistry I 前期 農学部 2015/04〜2016/03
食品生化学II Food Biochemistry II 後期 農学部 2015/04〜2016/03
酵素化学 Enzyme Chemistry 後期 農学部 2016/04〜2017/03
酵素化学実験及び実験法 Laboratory Course in Enzyme Chemistry 前期 農学部 2016/04〜2017/03
酵素化学専攻実験1 Experimental Course of Enzyme Chemistry1 通年 農学研究科 2016/04〜2017/03
酵素化学専攻実験2 Experimental Course of Enzyme Chemistry2 通年 農学研究科 2016/04〜2017/03
酵素化学専攻実験 Experimental Course of Enzyme Chemistry 通年 農学研究科 2016/04〜2017/03
酵素化学専攻演習1 Enzyme Chemistry Seminar1 通年 農学研究科 2016/04〜2017/03
酵素化学専攻演習2 Enzyme Chemistry Seminar2 通年 農学研究科 2016/04〜2017/03
酵素化学専攻演習 Enzyme Chemistry Seminar 通年 農学研究科 2016/04〜2017/03
食品分析化学 Analytical Chemistry in Food Science 後期 農学部 2016/04〜2017/03
食品基礎分子生物学II Principles of Molecular Biology in Food Science II 前期 農学部 2016/04〜2017/03
食品生物科学概論 Introduction to Food Bioscience 前期 農学部 2016/04〜2017/03
基礎生化学II Fundamental Biochemistry II 後期 農学部 2017/04〜2018/03
応用酵素化学 Applied Enzyme Chemistry 後期 農学部 2017/04〜2018/03
酵素化学 Enzyme Chemistry 後期 農学部 2017/04〜2018/03
酵素化学専攻実験1 Experimental Course of Enzyme Chemistry1 通年 農学研究科 2017/04〜2018/03
酵素化学専攻実験2 Experimental Course of Enzyme Chemistry2 通年 農学研究科 2017/04〜2018/03
酵素化学専攻演習1 Enzyme Chemistry Seminar1 通年 農学研究科 2017/04〜2018/03
酵素化学専攻演習2 Enzyme Chemistry Seminar2 通年 農学研究科 2017/04〜2018/03
酵素化学特論 Advanced Course of Enzyme Chemistry 前期集中 農学研究科 2017/04〜2018/03
食品分析化学 Analytical Chemistry in Food Science 後期 農学部 2017/04〜2018/03
食品基礎分子生物学II Principles of Molecular Biology in Food Science II 前期 農学部 2017/04〜2018/03
食品生化学実験及び実験法(I) Laboratory Course in Food Biochemistry (I) 前期 農学部 2017/04〜2018/03

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全学運営(役職等)
役職名 期間
放射線障害予防小委員会 委員 2013/04/01〜2015/03/31
学生生活委員会 委員 2017/04/01〜2019/03/31
学生生活委員会第一小委員会 委員 2017/04/01〜2019/03/31
京都大学奨学金返還免除候補者選考委員会 委員 2017/04/01〜2019/03/31
部局運営(役職等)
役職名 期間
学生生活委員会 委員 2013/04/01〜2015/03/31
制度・組織等検討検討委員会 委員 2015/04/01〜2017/03/31
男女共同参画推進委員会 委員 2015/04/01〜2017/03/31
食品生物科学科長 2015/04/01〜2016/03/31
評価委員会 委員 2015/04/01〜2018/03/31
放射線障害防止委員会 委員 2013/04/01〜2017/03/31
食品生物科学専攻 専攻長 2016/04/01〜2018/03/31
防火・防災委員会 委員 2016/04/01〜2018/03/31
研究科教務委員会 委員 2017/04/01〜2019/03/31
学部教務委員会 委員 2017/04/01〜2019/03/31
人権問題対策委員会 2017/04/01〜2019/03/31

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