高山 和雄

最終更新日時: 2020/07/07 17:14:32

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氏名(漢字/フリガナ/アルファベット表記)
高山 和雄/タカヤマ カズオ/Takayama, Kazuo
所属部署・職名(部局/所属/講座等/職名)
iPS細胞研究所/増殖分化機構研究部門/講師
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士(薬科学) 大阪大学
博士(薬科学) 大阪大学
ORCID ID
https://orcid.org/0000-0002-1132-2457
researchmap URL
https://researchmap.jp/kazu0
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Kanae Kawai, Ryosuke Negoro, Moe Ichikawa, Tomoki Yamashita, Sayaka Deguchi, Kazuo Harada, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi Kanae Kawai, Ryosuke Negoro, Moe Ichikawa, Tomoki Yamashita, Sayaka Deguchi, Kazuo Harada, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi Kanae Kawai, Ryosuke Negoro, Moe Ichikawa, Tomoki Yamashita, Sayaka Deguchi, Kazuo Harada, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies. Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies. Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies. Molecular therapy. Methods & clinical development, 17, 49-57 Molecular therapy. Methods & clinical development, 17, 49-57 Molecular therapy. Methods & clinical development, 17, 49-57 2020/06/12 英語 公開
Kazuo Takayama Kazuo Takayama Kazuo Takayama In Vitro and Animal Models for SARS-CoV-2 research. In Vitro and Animal Models for SARS-CoV-2 research. In Vitro and Animal Models for SARS-CoV-2 research. Trends in pharmacological sciences Trends in pharmacological sciences Trends in pharmacological sciences 2020/05/30 英語 研究論文(学術雑誌) 公開
Ayumi Kiso, Yukiko Toba, Susumu Tsutsumi, Sayaka Deguchi, Keisuke Igai, Saki Koshino, Yasuhito Tanaka, Kazuo Takayama, Hiroyuki Mizuguchi Ayumi Kiso, Yukiko Toba, Susumu Tsutsumi, Sayaka Deguchi, Keisuke Igai, Saki Koshino, Yasuhito Tanaka, Kazuo Takayama, Hiroyuki Mizuguchi Ayumi Kiso, Yukiko Toba, Susumu Tsutsumi, Sayaka Deguchi, Keisuke Igai, Saki Koshino, Yasuhito Tanaka, Kazuo Takayama, Hiroyuki Mizuguchi Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling. Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling. Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling. Hepatology communications, 4, 2, 255-267 Hepatology communications, 4, 2, 255-267 Hepatology communications, 4, 2, 255-267 2020/02 英語 公開
Yukiko Toba, Sayaka Deguchi, Natsumi Mimura, Ayaka Sakamoto, Kazuo Harada, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi Yukiko Toba, Sayaka Deguchi, Natsumi Mimura, Ayaka Sakamoto, Kazuo Harada, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi Yukiko Toba, Sayaka Deguchi, Natsumi Mimura, Ayaka Sakamoto, Kazuo Harada, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance. Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance. Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance. PloS one, 15, 2, e0229654 PloS one, 15, 2, e0229654 PloS one, 15, 2, e0229654 2020 英語 公開
Sayaka Deguchi, Tomoki Yamashita, Keisuke Igai, Kazuo Harada, Yukiko Toba, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi Sayaka Deguchi, Tomoki Yamashita, Keisuke Igai, Kazuo Harada, Yukiko Toba, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi Sayaka Deguchi, Tomoki Yamashita, Keisuke Igai, Kazuo Harada, Yukiko Toba, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells. Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells. Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells. Drug metabolism and disposition: the biological fate of chemicals, 47, 6, 632-638 Drug metabolism and disposition: the biological fate of chemicals, 47, 6, 632-638 Drug metabolism and disposition: the biological fate of chemicals, 47, 6, 632-638 2019/06 英語 公開
Yukiko Toba, Ayumi Kiso, Souichiro Nakamae, Fuminori Sakurai, Kazuo Takayama, Hiroyuki Mizuguchi Yukiko Toba, Ayumi Kiso, Souichiro Nakamae, Fuminori Sakurai, Kazuo Takayama, Hiroyuki Mizuguchi Yukiko Toba, Ayumi Kiso, Souichiro Nakamae, Fuminori Sakurai, Kazuo Takayama, Hiroyuki Mizuguchi FGF signal is not required for hepatoblast differentiation of human iPS cells. FGF signal is not required for hepatoblast differentiation of human iPS cells. FGF signal is not required for hepatoblast differentiation of human iPS cells. Scientific reports, 9, 1, 3713-3713 Scientific reports, 9, 1, 3713-3713 Scientific reports, 9, 1, 3713-3713 2019/03/06 英語 公開
Tomoki Yamashita, Kazuo Takayama, Mika Hori, Mariko Harada-Shiba, Hiroyuki Mizuguchi Tomoki Yamashita, Kazuo Takayama, Mika Hori, Mariko Harada-Shiba, Hiroyuki Mizuguchi Tomoki Yamashita, Kazuo Takayama, Mika Hori, Mariko Harada-Shiba, Hiroyuki Mizuguchi Pharmaceutical Research for Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cell and Genome Editing Technologies. Pharmaceutical Research for Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cell and Genome Editing Technologies. Pharmaceutical Research for Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cell and Genome Editing Technologies. Biological & pharmaceutical bulletin, 42, 3, 312-318 Biological & pharmaceutical bulletin, 42, 3, 312-318 Biological & pharmaceutical bulletin, 42, 3, 312-318 2019 英語 公開
Takayama K, Negoro R, Yamashita T, Kawai K, Ichikawa M, Mori T, Nakatsu N, Harada K, Ito S, Yamada H, Yamaura Y, Hirata K, Ishida S, Mizuguchi H Takayama K, Negoro R, Yamashita T, Kawai K, Ichikawa M, Mori T, Nakatsu N, Harada K, Ito S, Yamada H, Yamaura Y, Hirata K, Ishida S, Mizuguchi H Kazuo Takayama, Ryosuke Negoro, Tomoki Yamashita, Kanae Kawai, Moe Ichikawa, Takanori Mori, Noriyuki Nakatsu, Kazuo Harada, Sumito Ito, Hiroshi Yamada, Yoshiyuki Yamaura, Kazumasa Hirata, Seiichi Ishida, Hiroyuki Mizuguchi Generation of Human iPSC-Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction. Generation of Human iPSC-Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction. Generation of Human iPSC-Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction. Cellular and molecular gastroenterology and hepatology, 8, 3, 513-526 Cellular and molecular gastroenterology and hepatology, 8, 3, 513-526 Cellular and molecular gastroenterology and hepatology, 8, 3, 513-526 2019 英語 公開
Takayama K Takayama K Kazuo Takayama [Pharmaceutical Research on Liver Diseases Using iPS Cell and Genome Editing Technologies]. [Pharmaceutical Research on Liver Diseases Using iPS Cell and Genome Editing Technologies]. [Pharmaceutical Research on Liver Diseases Using iPS Cell and Genome Editing Technologies]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 139, 10, 1219-1225 Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 139, 10, 1219-1225 Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 139, 10, 1219-1225 2019 日本語 公開
Ryosuke Negoro, Kazuo Takayama, Kanae Kawai, Kazuo Harada, Fuminori Sakurai, Kazumasa Hirata, Hiroyuki Mizuguchi Ryosuke Negoro, Kazuo Takayama, Kanae Kawai, Kazuo Harada, Fuminori Sakurai, Kazumasa Hirata, Hiroyuki Mizuguchi Ryosuke Negoro, Kazuo Takayama, Kanae Kawai, Kazuo Harada, Fuminori Sakurai, Kazumasa Hirata, Hiroyuki Mizuguchi Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies. Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies. Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies. Stem cell reports, 11, 6, 1539-1550 Stem cell reports, 11, 6, 1539-1550 Stem cell reports, 11, 6, 1539-1550 2018/12/11 英語 公開
Matoba N, Yamashita T, Takayama K, Sakurai F, Mizuguchi H Matoba N, Yamashita T, Takayama K, Sakurai F, Mizuguchi H Matoba N, Yamashita T, Takayama K, Sakurai F, Mizuguchi H Optimal human iPS cell culture method for efficient hepatic differentiation. Optimal human iPS cell culture method for efficient hepatic differentiation. Optimal human iPS cell culture method for efficient hepatic differentiation. Differentiation; research in biological diversity, 104, 13-21 Differentiation; research in biological diversity, 104, 13-21 Differentiation; research in biological diversity, 104, 13-21 2018/09 公開
Kazuo Takayama, Yasuko Hagihara, Yukiko Toba, Kiyotoshi Sekiguchi, Fuminori Sakurai, Hiroyuki Mizuguchi Kazuo Takayama, Yasuko Hagihara, Yukiko Toba, Kiyotoshi Sekiguchi, Fuminori Sakurai, Hiroyuki Mizuguchi Kazuo Takayama, Yasuko Hagihara, Yukiko Toba, Kiyotoshi Sekiguchi, Fuminori Sakurai, Hiroyuki Mizuguchi Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research. Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research. Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research. Biomaterials, 161, 24-32 Biomaterials, 161, 24-32 Biomaterials, 161, 24-32 2018/04 英語 公開
Souichiro Nakamae, Yukiko Toba, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi Souichiro Nakamae, Yukiko Toba, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi Souichiro Nakamae, Yukiko Toba, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi Nanaomycin A Treatment Promotes Hepatoblast Differentiation from Human iPS Cells. Nanaomycin A Treatment Promotes Hepatoblast Differentiation from Human iPS Cells. Nanaomycin A Treatment Promotes Hepatoblast Differentiation from Human iPS Cells. Stem cells and development, 27, 6, 405-414 Stem cells and development, 27, 6, 405-414 Stem cells and development, 27, 6, 405-414 2018/03/15 英語 公開
Tomoki Yamashita, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi Tomoki Yamashita, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi Tomoki Yamashita, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells. Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells. Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells. Biochemical and biophysical research communications, 496, 4, 1269-1275 Biochemical and biophysical research communications, 496, 4, 1269-1275 Biochemical and biophysical research communications, 496, 4, 1269-1275 2018/02/19 英語 公開
Kazuo Takayama, Hiroyuki Mizuguchi Kazuo Takayama, Hiroyuki Mizuguchi Kazuo Takayama, Hiroyuki Mizuguchi Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy. Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy. Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy. ACS chemical biology, 13, 2, 449-454 ACS chemical biology, 13, 2, 449-454 ACS chemical biology, 13, 2, 449-454 2018/02/16 英語 公開
Ryota Okamoto, Kazuo Takayama, Naoki Akita, Yasuhito Nagamoto, Daiki Hosokawa, Shunsuke Iizuka, Fuminori Sakurai, Hiroshi Suemizu, Kazuo Ohashi, Hiroyuki Mizuguchi Ryota Okamoto, Kazuo Takayama, Naoki Akita, Yasuhito Nagamoto, Daiki Hosokawa, Shunsuke Iizuka, Fuminori Sakurai, Hiroshi Suemizu, Kazuo Ohashi, Hiroyuki Mizuguchi Ryota Okamoto, Kazuo Takayama, Naoki Akita, Yasuhito Nagamoto, Daiki Hosokawa, Shunsuke Iizuka, Fuminori Sakurai, Hiroshi Suemizu, Kazuo Ohashi, Hiroyuki Mizuguchi Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B. Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B. Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B. Cell transplantation, 27, 2, 299-309 Cell transplantation, 27, 2, 299-309 Cell transplantation, 27, 2, 299-309 2018/02 英語 公開
Kazuo Takayama, Naoki Akita, Natsumi Mimura, Rina Akahira, Yukimasa Taniguchi, Makoto Ikeda, Fuminori Sakurai, Osamu Ohara, Tomohiro Morio, Kiyotoshi Sekiguchi, Hiroyuki Mizuguchi Kazuo Takayama, Naoki Akita, Natsumi Mimura, Rina Akahira, Yukimasa Taniguchi, Makoto Ikeda, Fuminori Sakurai, Osamu Ohara, Tomohiro Morio, Kiyotoshi Sekiguchi, Hiroyuki Mizuguchi Kazuo Takayama, Naoki Akita, Natsumi Mimura, Rina Akahira, Yukimasa Taniguchi, Makoto Ikeda, Fuminori Sakurai, Osamu Ohara, Tomohiro Morio, Kiyotoshi Sekiguchi, Hiroyuki Mizuguchi Generation of safe and therapeutically effective human induced pluripotent stem cell-derived hepatocyte-like cells for regenerative medicine. Generation of safe and therapeutically effective human induced pluripotent stem cell-derived hepatocyte-like cells for regenerative medicine. Generation of safe and therapeutically effective human induced pluripotent stem cell-derived hepatocyte-like cells for regenerative medicine. Hepatology communications, 1, 10, 1058-1069 Hepatology communications, 1, 10, 1058-1069 Hepatology communications, 1, 10, 1058-1069 2017/12 英語 公開
Daiki Nakamori, Hiroki Akamine, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi Daiki Nakamori, Hiroki Akamine, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi Daiki Nakamori, Hiroki Akamine, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi y Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction y Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction y Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction SCIENTIFIC REPORTS, 7, 1, 16675 SCIENTIFIC REPORTS, 7, 1, 16675 SCIENTIFIC REPORTS, 7, 1, 16675 2017/11 英語 研究論文(学術雑誌) 公開
Fuminori Sakurai, Takemaru Kunito, Kazuo Takayama, Rina Hashimoto, Masashi Tachibana, Naoya Sakamoto, Takaji Wakita, Hiroyuki Mizuguchi Fuminori Sakurai, Takemaru Kunito, Kazuo Takayama, Rina Hashimoto, Masashi Tachibana, Naoya Sakamoto, Takaji Wakita, Hiroyuki Mizuguchi Fuminori Sakurai, Takemaru Kunito, Kazuo Takayama, Rina Hashimoto, Masashi Tachibana, Naoya Sakamoto, Takaji Wakita, Hiroyuki Mizuguchi Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells VIRUS RESEARCH, 242, 7-15 VIRUS RESEARCH, 242, 7-15 VIRUS RESEARCH, 242, 7-15 2017/10 英語 研究論文(学術雑誌) 公開
Morifumi Hanawa, Kazuo Takayama, Fuminori Sakurai, Masashi Tachibana, Hiroyuki Mizuguchi Morifumi Hanawa, Kazuo Takayama, Fuminori Sakurai, Masashi Tachibana, Hiroyuki Mizuguchi Morifumi Hanawa, Kazuo Takayama, Fuminori Sakurai, Masashi Tachibana, Hiroyuki Mizuguchi Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells STEM CELL REVIEWS AND REPORTS, 13, 4, 542-551 STEM CELL REVIEWS AND REPORTS, 13, 4, 542-551 STEM CELL REVIEWS AND REPORTS, 13, 4, 542-551 2017/08 英語 研究論文(学術雑誌) 公開
Seiji Mitani, Kazuo Takayama, Yasuhito Nagamoto, Kazuo Imagawa, Fuminori Sakurai, Masashi Tachibana, Ryo Sumazaki, Hiroyuki Mizuguchi Seiji Mitani, Kazuo Takayama, Yasuhito Nagamoto, Kazuo Imagawa, Fuminori Sakurai, Masashi Tachibana, Ryo Sumazaki, Hiroyuki Mizuguchi Seiji Mitani, Kazuo Takayama, Yasuhito Nagamoto, Kazuo Imagawa, Fuminori Sakurai, Masashi Tachibana, Ryo Sumazaki, Hiroyuki Mizuguchi Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling MOLECULAR THERAPY, 25, 6, 1420-1433 MOLECULAR THERAPY, 25, 6, 1420-1433 MOLECULAR THERAPY, 25, 6, 1420-1433 2017/06 英語 研究論文(学術雑誌) 公開
Kazuo Takayama, Keisuke Igai, Yasuko Hagihara, Rina Hashimoto, Morifumi Hanawa, Tetsushi Sakuma, Masashi Tachibana, Fuminori Sakurai, Takashi Yamamoto, Hiroyuki Mizuguchi Kazuo Takayama, Keisuke Igai, Yasuko Hagihara, Rina Hashimoto, Morifumi Hanawa, Tetsushi Sakuma, Masashi Tachibana, Fuminori Sakurai, Takashi Yamamoto, Hiroyuki Mizuguchi Kazuo Takayama, Keisuke Igai, Yasuko Hagihara, Rina Hashimoto, Morifumi Hanawa, Tetsushi Sakuma, Masashi Tachibana, Fuminori Sakurai, Takashi Yamamoto, Hiroyuki Mizuguchi Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system NUCLEIC ACIDS RESEARCH, 45, 9, 5198-5207 NUCLEIC ACIDS RESEARCH, 45, 9, 5198-5207 NUCLEIC ACIDS RESEARCH, 45, 9, 5198-5207 2017/05 英語 研究論文(学術雑誌) 公開
Fuminori Sakurai, Seiji Mitani, Tatsuro Yamamoto, Kazuo Takayama, Masashi Tachibana, Koichi Watashi, Takaji Wakita, Sayuki Iijima, Yasuhito Tanaka, Hiroyuki Mizuguchi Fuminori Sakurai, Seiji Mitani, Tatsuro Yamamoto, Kazuo Takayama, Masashi Tachibana, Koichi Watashi, Takaji Wakita, Sayuki Iijima, Yasuhito Tanaka, Hiroyuki Mizuguchi Fuminori Sakurai, Seiji Mitani, Tatsuro Yamamoto, Kazuo Takayama, Masashi Tachibana, Koichi Watashi, Takaji Wakita, Sayuki Iijima, Yasuhito Tanaka, Hiroyuki Mizuguchi Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection SCIENTIFIC REPORTS, 7, 45698 SCIENTIFIC REPORTS, 7, 45698 SCIENTIFIC REPORTS, 7, 45698 2017/04 英語 研究論文(学術雑誌) 公開
Takayuki Fukuda, Kazuo Takayama, Mitsuhi Hirata, Yu-Jung Liu, Kana Yanagihara, Mika Suga, Hiroyuki Mizuguchi, Miho K. Furue Takayuki Fukuda, Kazuo Takayama, Mitsuhi Hirata, Yu-Jung Liu, Kana Yanagihara, Mika Suga, Hiroyuki Mizuguchi, Miho K. Furue Takayuki Fukuda, Kazuo Takayama, Mitsuhi Hirata, Yu-Jung Liu, Kana Yanagihara, Mika Suga, Hiroyuki Mizuguchi, Miho K. Furue Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions EXPERIMENTAL CELL RESEARCH, 352, 2, 333-345 EXPERIMENTAL CELL RESEARCH, 352, 2, 333-345 EXPERIMENTAL CELL RESEARCH, 352, 2, 333-345 2017/03 英語 研究論文(学術雑誌) 公開
Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Kosuke Nakatani, Kazuo Takayama, Masashi Tachibana, Hiroyuki Mizuguhi Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Kosuke Nakatani, Kazuo Takayama, Masashi Tachibana, Hiroyuki Mizuguhi Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Kosuke Nakatani, Kazuo Takayama, Masashi Tachibana, Hiroyuki Mizuguhi Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40, 3, 272-277 BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40, 3, 272-277 BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40, 3, 272-277 2017/03 英語 研究論文(学術雑誌) 公開
Kazuo Imagawa, Kazuo Takayama, Shigemi Isoyama, Ken Tanikawa, Masato Shinkai, Kazuo Harada, Masashi Tachibana, Fuminori Sakurai, Emiko Noguchi, Kazumasa Hirata, Masayoshi Kage, Kenji Kawabata, Ryo Sumazaki, Hiroyuki Mizuguchi Kazuo Imagawa, Kazuo Takayama, Shigemi Isoyama, Ken Tanikawa, Masato Shinkai, Kazuo Harada, Masashi Tachibana, Fuminori Sakurai, Emiko Noguchi, Kazumasa Hirata, Masayoshi Kage, Kenji Kawabata, Ryo Sumazaki, Hiroyuki Mizuguchi Kazuo Imagawa, Kazuo Takayama, Shigemi Isoyama, Ken Tanikawa, Masato Shinkai, Kazuo Harada, Masashi Tachibana, Fuminori Sakurai, Emiko Noguchi, Kazumasa Hirata, Masayoshi Kage, Kenji Kawabata, Ryo Sumazaki, Hiroyuki Mizuguchi Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells Scientific Reports, 7, 41806 Scientific Reports, 7, 41806 Scientific Reports, 7, 41806 2017/02 英語 研究論文(学術雑誌) 公開
Kazuo Takayama, Hiroyuki Mizuguchi Kazuo Takayama, Hiroyuki Mizuguchi Kazuo Takayama, Hiroyuki Mizuguchi Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening DRUG METABOLISM AND PHARMACOKINETICS, 32, 1, 12-20 DRUG METABOLISM AND PHARMACOKINETICS, 32, 1, 12-20 DRUG METABOLISM AND PHARMACOKINETICS, 32, 1, 12-20 2017/02 英語 公開
Kana Yanagihara, Yujung Liu, Kei Kanie, Kazuo Takayama, Minako Kokunugi, Mitsuhi Hirata, Takayuki Fukuda, Mika Suga, Hiroki Nikawa, Hiroyuki Mizuguchi, Ryuji Kato, Miho K. Furue Kana Yanagihara, Yujung Liu, Kei Kanie, Kazuo Takayama, Minako Kokunugi, Mitsuhi Hirata, Takayuki Fukuda, Mika Suga, Hiroki Nikawa, Hiroyuki Mizuguchi, Ryuji Kato, Miho K. Furue Kana Yanagihara, Yujung Liu, Kei Kanie, Kazuo Takayama, Minako Kokunugi, Mitsuhi Hirata, Takayuki Fukuda, Mika Suga, Hiroki Nikawa, Hiroyuki Mizuguchi, Ryuji Kato, Miho K. Furue Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells STEM CELLS AND DEVELOPMENT, 25, 24, 1884-1897 STEM CELLS AND DEVELOPMENT, 25, 24, 1884-1897 STEM CELLS AND DEVELOPMENT, 25, 24, 1884-1897 2016/12 英語 研究論文(学術雑誌) 公開
Yasuhito Nagamoto, Kazuo Takayama, Kazuo Ohashi, Ryota Okamoto, Fuminori Sakurai, Masashi Tachibana, Kenji Kawabata, Hiroyuki Mizuguchi Yasuhito Nagamoto, Kazuo Takayama, Kazuo Ohashi, Ryota Okamoto, Fuminori Sakurai, Masashi Tachibana, Kenji Kawabata, Hiroyuki Mizuguchi Yasuhito Nagamoto, Kazuo Takayama, Kazuo Ohashi, Ryota Okamoto, Fuminori Sakurai, Masashi Tachibana, Kenji Kawabata, Hiroyuki Mizuguchi Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure JOURNAL OF HEPATOLOGY, 64, 5, 1068-1075 JOURNAL OF HEPATOLOGY, 64, 5, 1068-1075 JOURNAL OF HEPATOLOGY, 64, 5, 1068-1075 2016/05 英語 研究論文(学術雑誌) 公開
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Nakamori D, Takayama K, co-first author, Nagamoto Y, Mitani S, Sakurai F, Tachibana M, Mizuguchi H Nakamori D, Takayama K, co-first author, Nagamoto Y, Mitani S, Sakurai F, Tachibana M, Mizuguchi H Daiki Nakamori, Kazuo Takayama, Yasuhito Nagamoto, Seiji Mitani, Fuminori Sakurai, Masashi Tachibana, Hiroyuki Mizuguchi Hepatic Maturation of Human iPS Cell-Derived Hepatocyte-Like Cells by ATF5, c/EBPα, and PROX1 Transduction Hepatic Maturation of Human iPS Cell-Derived Hepatocyte-Like Cells by ATF5, c/EBPα, and PROX1 Transduction Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBP alpha, and PROX1 transduction Biochem Biophys Res Commun., 469, 3, 424-429 Biochem Biophys Res Commun., 469, 3, 424-429 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 469, 3, 424-429 2016/01 英語 研究論文(学術雑誌) 公開
Ozawa T, Takayama K, co-first author, Okamoto R, Negoro R, Sakurai F, Tachibana M, Kawabata K, Mizuguchi H Ozawa T, Takayama K, co-first author, Okamoto R, Negoro R, Sakurai F, Tachibana M, Kawabata K, Mizuguchi H Ozawa T, Takayama K, co-first author, Okamoto R, Negoro R, Sakurai F, Tachibana M, Kawabata K, Mizuguchi H Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine Scientific Reports, 12, 5, 16479 Scientific Reports, 12, 5, 16479 Scientific Reports, 12, 5, 16479 2015/11 英語 研究論文(学術雑誌) 公開
Kazuo Takayama Kazuo Takayama Kazuo Takayama Establishment of a Method of Hepatocyte Differentiation from Human Pluripotent Stem Cells for Innovative Drug Development Establishment of a Method of Hepatocyte Differentiation from Human Pluripotent Stem Cells for Innovative Drug Development Establishment of a Method of Hepatocyte Differentiation from Human Pluripotent Stem Cells for Innovative Drug Development YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 135, 10, 1141-1146 YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 135, 10, 1141-1146 YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 135, 10, 1141-1146 2015/10 日本語 公開
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Katsuhisa Tashiro, Nobue Hirata, Atsumasa Okada, Tomoko Yamaguchi, Kazuo Takayama, Hiroyuki Mizuguchi, Kenji Kawabata Katsuhisa Tashiro, Nobue Hirata, Atsumasa Okada, Tomoko Yamaguchi, Kazuo Takayama, Hiroyuki Mizuguchi, Kenji Kawabata Katsuhisa Tashiro, Nobue Hirata, Atsumasa Okada, Tomoko Yamaguchi, Kazuo Takayama, Hiroyuki Mizuguchi, Kenji Kawabata Expression of Coxsackievirus and Adenovirus Receptor Separates Hematopoietic and Cardiac Progenitor Cells in Fetal Liver Kinase 1-Expressing Mesoderm Expression of Coxsackievirus and Adenovirus Receptor Separates Hematopoietic and Cardiac Progenitor Cells in Fetal Liver Kinase 1-Expressing Mesoderm Expression of Coxsackievirus and Adenovirus Receptor Separates Hematopoietic and Cardiac Progenitor Cells in Fetal Liver Kinase 1-Expressing Mesoderm STEM CELLS TRANSLATIONAL MEDICINE, 4, 5, 424-436 STEM CELLS TRANSLATIONAL MEDICINE, 4, 5, 424-436 STEM CELLS TRANSLATIONAL MEDICINE, 4, 5, 424-436 2015/05 英語 研究論文(学術雑誌) 公開
Katsuhisa Tashiro, Nobue Hirata, Atsumasa Okada, Tomoko Yamaguchi, Kazuo Takayama, Hiroyuki Mizuguchi, Kenji Kawabata Katsuhisa Tashiro, Nobue Hirata, Atsumasa Okada, Tomoko Yamaguchi, Kazuo Takayama, Hiroyuki Mizuguchi, Kenji Kawabata Katsuhisa Tashiro, Nobue Hirata, Atsumasa Okada, Tomoko Yamaguchi, Kazuo Takayama, Hiroyuki Mizuguchi, Kenji Kawabata Expression of Coxsackievirus and Adenovirus Receptor Separates Hematopoietic and Cardiac Progenitor Cells in Fetal Liver Kinase 1-Expressing Mesoderm Expression of Coxsackievirus and Adenovirus Receptor Separates Hematopoietic and Cardiac Progenitor Cells in Fetal Liver Kinase 1-Expressing Mesoderm Expression of Coxsackievirus and Adenovirus Receptor Separates Hematopoietic and Cardiac Progenitor Cells in Fetal Liver Kinase 1-Expressing Mesoderm STEM CELLS TRANSLATIONAL MEDICINE, 4, 5, 424-436 STEM CELLS TRANSLATIONAL MEDICINE, 4, 5, 424-436 STEM CELLS TRANSLATIONAL MEDICINE, 4, 5, 424-436 2015/05 英語 研究論文(学術雑誌) 公開
Yasuhito Nagamoto, Kazuo Takayama, Katsuhisa Tashiro, Chise Tateno, Fuminori Sakurai, Masashi Tachibana, Kenji Kawabata, Kazuo Ikeda, Yasuhito Tanaka, Hiroyuki Mizuguchi Yasuhito Nagamoto, Kazuo Takayama, Katsuhisa Tashiro, Chise Tateno, Fuminori Sakurai, Masashi Tachibana, Kenji Kawabata, Kazuo Ikeda, Yasuhito Tanaka, Hiroyuki Mizuguchi Yasuhito Nagamoto, Kazuo Takayama, Katsuhisa Tashiro, Chise Tateno, Fuminori Sakurai, Masashi Tachibana, Kenji Kawabata, Kazuo Ikeda, Yasuhito Tanaka, Hiroyuki Mizuguchi Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene CELL TRANSPLANTATION, 24, 6, 1127-1138 CELL TRANSPLANTATION, 24, 6, 1127-1138 CELL TRANSPLANTATION, 24, 6, 1127-1138 2015 英語 研究論文(学術雑誌) 公開
Yasuhito Nagamoto, Kazuo Takayama, Katsuhisa Tashiro, Chise Tateno, Fuminori Sakurai, Masashi Tachibana, Kenji Kawabata, Kazuo Ikeda, Yasuhito Tanaka, Hiroyuki Mizuguchi Yasuhito Nagamoto, Kazuo Takayama, Katsuhisa Tashiro, Chise Tateno, Fuminori Sakurai, Masashi Tachibana, Kenji Kawabata, Kazuo Ikeda, Yasuhito Tanaka, Hiroyuki Mizuguchi Yasuhito Nagamoto, Kazuo Takayama, Katsuhisa Tashiro, Chise Tateno, Fuminori Sakurai, Masashi Tachibana, Kenji Kawabata, Kazuo Ikeda, Yasuhito Tanaka, Hiroyuki Mizuguchi Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene CELL TRANSPLANTATION, 24, 6, 1127-1138 CELL TRANSPLANTATION, 24, 6, 1127-1138 CELL TRANSPLANTATION, 24, 6, 1127-1138 2015 英語 研究論文(学術雑誌) 公開
Kazuo Takayama, Yuta Morisaki, Shuichi Kuno, Yasuhito Nagamoto, Kazuo Harada, Norihisa Furukawa, Manami Ohtaka, Ken Nishimura, Kazuo Imagawa, Fuminori Sakurai, Masashi Tachibana, Ryo Sumazaki, Emiko Noguchi, Mahito Nakanishi, Kazumasa Hirata, Kenji Kawabata, Hiroyuki Mizuguchi Kazuo Takayama, Yuta Morisaki, Shuichi Kuno, Yasuhito Nagamoto, Kazuo Harada, Norihisa Furukawa, Manami Ohtaka, Ken Nishimura, Kazuo Imagawa, Fuminori Sakurai, Masashi Tachibana, Ryo Sumazaki, Emiko Noguchi, Mahito Nakanishi, Kazumasa Hirata, Kenji Kawabata, Hiroyuki Mizuguchi Kazuo Takayama, Yuta Morisaki, Shuichi Kuno, Yasuhito Nagamoto, Kazuo Harada, Norihisa Furukawa, Manami Ohtaka, Ken Nishimura, Kazuo Imagawa, Fuminori Sakurai, Masashi Tachibana, Ryo Sumazaki, Emiko Noguchi, Mahito Nakanishi, Kazumasa Hirata, Kenji Kawabata, Hiroyuki Mizuguchi Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111, 47, 16772-16777 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111, 47, 16772-16777 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111, 47, 16772-16777 2014/11 英語 研究論文(学術雑誌) 公開
Hitoshi Watanabe, Kazuo Takayama, Mitsuru Inamura, Masashi Tachibana, Natsumi Mimura, Kazufumi Katayama, Katsuhisa Tashiro, Yasuhito Nagamoto, Fuminori Sakurai, Kenji Kawabata, Miho Kusuda Furue, Hiroyuki Mizuguchi Hitoshi Watanabe, Kazuo Takayama, Mitsuru Inamura, Masashi Tachibana, Natsumi Mimura, Kazufumi Katayama, Katsuhisa Tashiro, Yasuhito Nagamoto, Fuminori Sakurai, Kenji Kawabata, Miho Kusuda Furue, Hiroyuki Mizuguchi Hitoshi Watanabe, Kazuo Takayama, Mitsuru Inamura, Masashi Tachibana, Natsumi Mimura, Kazufumi Katayama, Katsuhisa Tashiro, Yasuhito Nagamoto, Fuminori Sakurai, Kenji Kawabata, Miho Kusuda Furue, Hiroyuki Mizuguchi HHEX Promotes Hepatic-Lineage Specification through the Negative Regulation of Eomesodermin HHEX Promotes Hepatic-Lineage Specification through the Negative Regulation of Eomesodermin HHEX Promotes Hepatic-Lineage Specification through the Negative Regulation of Eomesodermin PLOS ONE, 9, 3, e90791 PLOS ONE, 9, 3, e90791 PLOS ONE, 9, 3, e90791 2014/03 英語 研究論文(学術雑誌) 公開
Takayama K, Kawabata K, Nagamoto Y, Inamura M, Ohashi K, Okuno H, Yamaguchi T, Tashiro K, Sakurai F, Hayakawa T, Okano T, Furue MK, Mizuguchi H Takayama K, Kawabata K, Nagamoto Y, Inamura M, Ohashi K, Okuno H, Yamaguchi T, Tashiro K, Sakurai F, Hayakawa T, Okano T, Furue MK, Mizuguchi H Kazuo Takayama, Kenji Kawabata, Yasuhito Nagamoto, Mitsuru Inamura, Kazuo Ohashi, Hiroko Okuno, Tomoko Yamaguchi, Katsuhisa Tashiro, Fuminori Sakurai, Takao Hayakawa, Teruo Okano, Miho Kusada Furue, Hiroyuki Mizuguchi CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determines the hepatoblast fate decision. CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determines the hepatoblast fate decision. CCAAT/enhancer binding protein-mediated regulation of TGF beta receptor 2 expression determines the hepatoblast fate decision Development (Cambridge, England), 141, 1, 91-100 Development (Cambridge, England), 141, 1, 91-100 DEVELOPMENT, 141, 1, 91-100 2014/01 英語 研究論文(学術雑誌) 公開
Takayama K, Kawabata K, Nagamoto Y, Inamura M, Ohashi K, Okuno H, Yamaguchi T, Tashiro K, Sakurai F, Hayakawa T, Okano T, Furue MK, Mizuguchi H Takayama K, Kawabata K, Nagamoto Y, Inamura M, Ohashi K, Okuno H, Yamaguchi T, Tashiro K, Sakurai F, Hayakawa T, Okano T, Furue MK, Mizuguchi H Kazuo Takayama, Kenji Kawabata, Yasuhito Nagamoto, Mitsuru Inamura, Kazuo Ohashi, Hiroko Okuno, Tomoko Yamaguchi, Katsuhisa Tashiro, Fuminori Sakurai, Takao Hayakawa, Teruo Okano, Miho Kusada Furue, Hiroyuki Mizuguchi CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determine the hepatoblast fate decision CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determine the hepatoblast fate decision CCAAT/enhancer binding protein-mediated regulation of TGF beta receptor 2 expression determines the hepatoblast fate decision Development, 141, 1, 91-100 Development, 141, 1, 91-100 DEVELOPMENT, 141, 1, 91-100 2014/01 英語 研究論文(学術雑誌) 公開
Kazuo Takayama, Yasuhito Nagamoto, Natsumi Mimura, Katsuhisa Tashiro, Fuminori Sakurai, Masashi Tachibana, Takao Hayakawa, Kenji Kawabata, Hiroyuki Mizuguchi Kazuo Takayama, Yasuhito Nagamoto, Natsumi Mimura, Katsuhisa Tashiro, Fuminori Sakurai, Masashi Tachibana, Takao Hayakawa, Kenji Kawabata, Hiroyuki Mizuguchi Kazuo Takayama, Yasuhito Nagamoto, Natsumi Mimura, Katsuhisa Tashiro, Fuminori Sakurai, Masashi Tachibana, Takao Hayakawa, Kenji Kawabata, Hiroyuki Mizuguchi Long-Term Self-Renewal of Human ES/iPS-Derived Hepatoblast-like Cells on Human Laminin 111-Coated Dishes Long-Term Self-Renewal of Human ES/iPS-Derived Hepatoblast-like Cells on Human Laminin 111-Coated Dishes Long-Term Self-Renewal of Human ES/iPS-Derived Hepatoblast-like Cells on Human Laminin 111-Coated Dishes STEM CELL REPORTS, 1, 4, 322-335 STEM CELL REPORTS, 1, 4, 322-335 STEM CELL REPORTS, 1, 4, 322-335 2013/10 英語 研究論文(学術雑誌) 公開
Kazuo Takayama, Kenji Kawabata, Yasuhito Nagamoto, Keisuke Kishimoto, Katsuhisa Tashiro, Fuminori Sakurai, Masashi Tachibana, Katsuhiro Kanda, Takao Hayakawa, Miho Kusuda Furue, Hiroyuki Mizuguchi Kazuo Takayama, Kenji Kawabata, Yasuhito Nagamoto, Keisuke Kishimoto, Katsuhisa Tashiro, Fuminori Sakurai, Masashi Tachibana, Katsuhiro Kanda, Takao Hayakawa, Miho Kusuda Furue, Hiroyuki Mizuguchi Kazuo Takayama, Kenji Kawabata, Yasuhito Nagamoto, Keisuke Kishimoto, Katsuhisa Tashiro, Fuminori Sakurai, Masashi Tachibana, Katsuhiro Kanda, Takao Hayakawa, Miho Kusuda Furue, Hiroyuki Mizuguchi 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing. 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing. 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing. Biomaterials, 34, 7, 1781-9 Biomaterials, 34, 7, 1781-9 Biomaterials, 34, 7, 1781-9 2013/02 英語 研究論文(学術雑誌) 公開
Takayama K, Inamura M, Kawabata K, Sugawara M, Kikuchi K, Higuchi M, Nagamoto Y, Watanabe H, Tashiro K, Sakurai F, Hayakawa T, Furue MK, Mizuguchi H Takayama K, Inamura M, Kawabata K, Sugawara M, Kikuchi K, Higuchi M, Nagamoto Y, Watanabe H, Tashiro K, Sakurai F, Hayakawa T, Furue MK, Mizuguchi H Kazuo Takayama, Mitsuru Inamura, Kenji Kawabata, Michiko Sugawara, Kiyomi Kikuchi, Maiko Higuchi, Yasuhito Nagamoto, Hitoshi Watanabe, Katsuhisa Tashiro, Fuminori Sakurai, Takao Hayakawa, Miho Kusuda Furue, Hiroyuki Mizuguchi Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction. Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction. Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1 alpha transduction Journal of Hepatology, 57, 3, 628-636 Journal of Hepatology, 57, 3, 628-636 JOURNAL OF HEPATOLOGY, 57, 3, 628-636 2012/09 英語 研究論文(学術雑誌) 公開
Yasuhito Nagamoto, Katsuhisa Tashiro, Kazuo Takayama, Kazuo Ohashi, Kenji Kawabata, Fuminori Sakurai, Masashi Tachibana, Takao Hayakawa, Miho Kusuda Furue, Hiroyuki Mizuguchi Yasuhito Nagamoto, Katsuhisa Tashiro, Kazuo Takayama, Kazuo Ohashi, Kenji Kawabata, Fuminori Sakurai, Masashi Tachibana, Takao Hayakawa, Miho Kusuda Furue, Hiroyuki Mizuguchi Yasuhito Nagamoto, Katsuhisa Tashiro, Kazuo Takayama, Kazuo Ohashi, Kenji Kawabata, Fuminori Sakurai, Masashi Tachibana, Takao Hayakawa, Miho Kusuda Furue, Hiroyuki Mizuguchi The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets BIOMATERIALS, 33, 18, 4526-4534 BIOMATERIALS, 33, 18, 4526-4534 BIOMATERIALS, 33, 18, 4526-4534 2012/06 英語 研究論文(学術雑誌) 公開
Takayama K, Inamura M, Kawabata K, Katayama K, Higuchi M, Tashiro K, Nonaka A, Sakurai F, Hayakawa T, Furue MK, Mizuguchi H Takayama K, Inamura M, Kawabata K, Katayama K, Higuchi M, Tashiro K, Nonaka A, Sakurai F, Hayakawa T, Furue MK, Mizuguchi H Kazuo Takayama, Mitsuru Inamura, Kenji Kawabata, Kazufumi Katayama, Maiko Higuchi, Katsuhisa Tashiro, Aki Nonaka, Fuminori Sakurai, Takao Hayakawa, Miho Kusuda Furue, Hiroyuki Mizuguchi Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction. Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction. Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4 alpha Transduction Molecular therapy : the journal of the American Society of Gene Therapy, 20, 1, 127-137 Molecular therapy : the journal of the American Society of Gene Therapy, 20, 1, 127-137 MOLECULAR THERAPY, 20, 1, 127-137 2012/01 英語 研究論文(学術雑誌) 公開
Takayama K, Inamura M, Kawabata K, Katayama K, Higuchi M, Tashiro K, Nonaka A, Sakurai F, Hayakawa T, Furue MK, Mizuguchi H Takayama K, Inamura M, Kawabata K, Katayama K, Higuchi M, Tashiro K, Nonaka A, Sakurai F, Hayakawa T, Furue MK, Mizuguchi H Kazuo Takayama, Mitsuru Inamura, Kenji Kawabata, Kazufumi Katayama, Maiko Higuchi, Katsuhisa Tashiro, Aki Nonaka, Fuminori Sakurai, Takao Hayakawa, Miho Kusuda Furue, Hiroyuki Mizuguchi Efficient generation of functional hepatocytes from human embryonic stem cells and induced cells by HNF4α transduction Efficient generation of functional hepatocytes from human embryonic stem cells and induced cells by HNF4α transduction Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4 alpha Transduction Mol Ther., 20, 1, 127-137 Mol Ther., 20, 1, 127-137 MOLECULAR THERAPY, 20, 1, 127-137 2012/01 英語 研究論文(学術雑誌) 公開
Kawabata K, Takayama K, Nagamoto Y, Saldon M.S, Higuchi M, Mizuguchi H Kawabata K, Takayama K, Nagamoto Y, Saldon M.S, Higuchi M, Mizuguchi H Kawabata K, Takayama K, Nagamoto Y, Saldon M.S, Higuchi M, Mizuguchi H Endodermal and Hepatic Differentiation from Human Embryonic Stem Cells and Human Induced Pluripotent Stem Cells. Endodermal and Hepatic Differentiation from Human Embryonic Stem Cells and Human Induced Pluripotent Stem Cells. Endodermal and Hepatic Differentiation from Human Embryonic Stem Cells and Human Induced Pluripotent Stem Cells. J Stem Cell Res Ther., S10:002. J Stem Cell Res Ther., S10:002. J Stem Cell Res Ther., S10:002. 2012 英語 研究論文(学術雑誌) 公開
Takeshi Yoshida, Kazuo Takayama, Masuo Kondoh, Fuminori Sakurai, Hideki Tani, Naoya Sakamoto, Yoshiharu Matsuura, Hiroyuki Mizuguchi, Kiyohito Yagi Takeshi Yoshida, Kazuo Takayama, Masuo Kondoh, Fuminori Sakurai, Hideki Tani, Naoya Sakamoto, Yoshiharu Matsuura, Hiroyuki Mizuguchi, Kiyohito Yagi Takeshi Yoshida, Kazuo Takayama, Masuo Kondoh, Fuminori Sakurai, Hideki Tani, Naoya Sakamoto, Yoshiharu Matsuura, Hiroyuki Mizuguchi, Kiyohito Yagi Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 416, 1-2, 119-124 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 416, 1-2, 119-124 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 416, 1-2, 119-124 2011/12 英語 研究論文(学術雑誌) 公開
Kazuo Takayama, Mitsuru Inamura, Kenji Kawabata, Katsuhisa Tashiro, Kazufumi Katayama, Fuminori Sakurai, Takao Hayakawa, Miho Kusuda Furue, Hiroyuki Mizuguchi Kazuo Takayama, Mitsuru Inamura, Kenji Kawabata, Katsuhisa Tashiro, Kazufumi Katayama, Fuminori Sakurai, Takao Hayakawa, Miho Kusuda Furue, Hiroyuki Mizuguchi Kazuo Takayama, Mitsuru Inamura, Kenji Kawabata, Katsuhisa Tashiro, Kazufumi Katayama, Fuminori Sakurai, Takao Hayakawa, Miho Kusuda Furue, Hiroyuki Mizuguchi Efficient and Directive Generation of Two Distinct Endoderm Lineages from Human ESCs and iPSCs by Differentiation Stage-Specific SOX17 Transduction Efficient and Directive Generation of Two Distinct Endoderm Lineages from Human ESCs and iPSCs by Differentiation Stage-Specific SOX17 Transduction Efficient and Directive Generation of Two Distinct Endoderm Lineages from Human ESCs and iPSCs by Differentiation Stage-Specific SOX17 Transduction PLOS ONE, 6, 7, e21780 PLOS ONE, 6, 7, e21780 PLOS ONE, 6, 7, e21780 2011/07 英語 研究論文(学術雑誌) 公開
Mitsuru Inamura, Kenji Kawabata, Kazuo Takayama, Katsuhisa Tashiro, Fuminori Sakurai, Kazufumi Katayama, Masashi Toyoda, Hidenori Akutsu, Yoshitaka Miyagawa, Hajime Okita, Nobutaka Kiyokawa, Akihiro Umezawa, Takao Hayakawa, Miho K. Furue, Hiroyuki Mizuguchi Mitsuru Inamura, Kenji Kawabata, Kazuo Takayama, Katsuhisa Tashiro, Fuminori Sakurai, Kazufumi Katayama, Masashi Toyoda, Hidenori Akutsu, Yoshitaka Miyagawa, Hajime Okita, Nobutaka Kiyokawa, Akihiro Umezawa, Takao Hayakawa, Miho K. Furue, Hiroyuki Mizuguchi Mitsuru Inamura, Kenji Kawabata, Kazuo Takayama, Katsuhisa Tashiro, Fuminori Sakurai, Kazufumi Katayama, Masashi Toyoda, Hidenori Akutsu, Yoshitaka Miyagawa, Hajime Okita, Nobutaka Kiyokawa, Akihiro Umezawa, Takao Hayakawa, Miho K. Furue, Hiroyuki Mizuguchi Efficient Generation of Hepatoblasts From Human ES Cells and iPS Cells by Transient Overexpression of Homeobox Gene HEX Efficient Generation of Hepatoblasts From Human ES Cells and iPS Cells by Transient Overexpression of Homeobox Gene HEX Efficient Generation of Hepatoblasts From Human ES Cells and iPS Cells by Transient Overexpression of Homeobox Gene HEX MOLECULAR THERAPY, 19, 2, 400-407 MOLECULAR THERAPY, 19, 2, 400-407 MOLECULAR THERAPY, 19, 2, 400-407 2011/02 英語 研究論文(学術雑誌) 公開
Katsuhisa Tashiro, Kenji Kawabata, Mitsuru Inamura, Kazuo Takayama, Norihisa Furukawa, Fuminori Sakurai, Kazufumi Katayama, Takao Hayakawa, Miho Kusuda Furue, Hiroyuki Mizuguchi Katsuhisa Tashiro, Kenji Kawabata, Mitsuru Inamura, Kazuo Takayama, Norihisa Furukawa, Fuminori Sakurai, Kazufumi Katayama, Takao Hayakawa, Miho Kusuda Furue, Hiroyuki Mizuguchi Katsuhisa Tashiro, Kenji Kawabata, Mitsuru Inamura, Kazuo Takayama, Norihisa Furukawa, Fuminori Sakurai, Kazufumi Katayama, Takao Hayakawa, Miho Kusuda Furue, Hiroyuki Mizuguchi Adenovirus Vector-Mediated Efficient Transduction into Human Embryonic and Induced Pluripotent Stem Cells Adenovirus Vector-Mediated Efficient Transduction into Human Embryonic and Induced Pluripotent Stem Cells Adenovirus Vector-Mediated Efficient Transduction into Human Embryonic and Induced Pluripotent Stem Cells CELLULAR REPROGRAMMING, 12, 5, 501-507 CELLULAR REPROGRAMMING, 12, 5, 501-507 CELLULAR REPROGRAMMING, 12, 5, 501-507 2010/10 英語 研究論文(学術雑誌) 公開

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著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Ryosuke Negoro, Kanae Kawai, Moe Ichikawa, Sayaka Deguchi, Kazuo Takayama, Hiroyuki Mizuguchi Ryosuke Negoro, Kanae Kawai, Moe Ichikawa, Sayaka Deguchi, Kazuo Takayama, Hiroyuki Mizuguchi Ryosuke Negoro, Kanae Kawai, Moe Ichikawa, Sayaka Deguchi, Kazuo Takayama, Hiroyuki Mizuguchi Establishment of MDR1-knockout human induced pluripotent stem cell line. Establishment of MDR1-knockout human induced pluripotent stem cell line. Establishment of MDR1-knockout human induced pluripotent stem cell line. Drug metabolism and pharmacokinetics Drug metabolism and pharmacokinetics Drug metabolism and pharmacokinetics 2020/02/10 英語 公開
Sayaka Deguchi, Kazuo Takayama, Hiroyuki Mizuguchi Sayaka Deguchi, Kazuo Takayama, Hiroyuki Mizuguchi Sayaka Deguchi, Kazuo Takayama, Hiroyuki Mizuguchi Generation of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells for Cellular Medicine. Generation of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells for Cellular Medicine. Generation of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells for Cellular Medicine. Biological & pharmaceutical bulletin, 43, 4, 608-615 Biological & pharmaceutical bulletin, 43, 4, 608-615 Biological & pharmaceutical bulletin, 43, 4, 608-615 2020 英語 公開
高山 和雄, 萩原 康子, 関口 清俊, 森尾 友宏, 小原 收, 立花 雅史, 櫻井 文教, 水口 裕之 高山 和雄, 萩原 康子, 関口 清俊, 森尾 友宏, 小原 收, 立花 雅史, 櫻井 文教, 水口 裕之 高山 和雄, 萩原 康子, 関口 清俊, 森尾 友宏, 小原 收, 立花 雅史, 櫻井 文教, 水口 裕之 再生医療への応用を見据えた臨床グレートのヒトiPS細胞由来肝細胞の作製 再生医療への応用を見据えた臨床グレートのヒトiPS細胞由来肝細胞の作製 再生医療への応用を見据えた臨床グレートのヒトiPS細胞由来肝細胞の作製 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [1P0999]-[1P0999] 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [1P0999]-[1P0999] 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [1P0999]-[1P0999] 2015/12 日本語 公開
Kazuo Imagawa, Kazuo Takayama, Shigemi Isoyama, Ken Tanikawa, Masato Shinkai, Masayoshi Kage, Kenji Kawabata, Ryo Sumazaki, Hiroyuki Mizuguchi Kazuo Imagawa, Kazuo Takayama, Shigemi Isoyama, Ken Tanikawa, Masato Shinkai, Masayoshi Kage, Kenji Kawabata, Ryo Sumazaki, Hiroyuki Mizuguchi Kazuo Imagawa, Kazuo Takayama, Shigemi Isoyama, Ken Tanikawa, Masato Shinkai, Masayoshi Kage, Kenji Kawabata, Ryo Sumazaki, Hiroyuki Mizuguchi Human iPSC-derived hepatocyte-like cells generated from patients with bile salt export pump deficiency recapitulate the phenotype of progressive familial intrahepatic cholestasis type 2 Human iPSC-derived hepatocyte-like cells generated from patients with bile salt export pump deficiency recapitulate the phenotype of progressive familial intrahepatic cholestasis type 2 Human iPSC-derived hepatocyte-like cells generated from patients with bile salt export pump deficiency recapitulate the phenotype of progressive familial intrahepatic cholestasis type 2 HEPATOLOGY, 62, 1032A-1033A HEPATOLOGY, 62, 1032A-1033A HEPATOLOGY, 62, 1032A-1033A 2015/10 英語 研究発表要旨(国際会議) 公開
Seiji Yamane, Takeshi Yoshida, Kazuo Takayama, Masuo Kondoh, Fuminori Sakurai, Hiroyuki Mizuguchi, Kiyohito Yagi Seiji Yamane, Takeshi Yoshida, Kazuo Takayama, Masuo Kondoh, Fuminori Sakurai, Hiroyuki Mizuguchi, Kiyohito Yagi Seiji Yamane, Takeshi Yoshida, Kazuo Takayama, Masuo Kondoh, Fuminori Sakurai, Hiroyuki Mizuguchi, Kiyohito Yagi Human iPS-derived hepatocyte-like cells as a model for hepatitis C virus infection Human iPS-derived hepatocyte-like cells as a model for hepatitis C virus infection Human iPS-derived hepatocyte-like cells as a model for hepatitis C virus infection FASEB JOURNAL, 26 FASEB JOURNAL, 26 FASEB JOURNAL, 26 2012/04 英語 研究発表要旨(国際会議) 公開
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発明者 発明者(日本語) 発明者(英語) 発明の名称 発明の名称(日本語) 発明の名称(英語) 審査の段階 番号 年月 公開
水口 裕之, 高山 和雄 水口 裕之, 高山 和雄 多能性幹細胞の遺伝子ターゲティング方法 多能性幹細胞の遺伝子ターゲティング方法 特許公開 特開2017-018026 2017/01/26 公開
水口 裕之, 川端 健二, 高山 和雄 水口 裕之, 川端 健二, 高山 和雄 幹細胞から肝細胞への分化誘導方法 幹細胞から肝細胞への分化誘導方法 特許登録 特許第5970245号 2016/07/15 公開
水口 裕之, 高山 和雄 水口 裕之, 高山 和雄 薬物評価用細胞及び薬物評価方法 薬物評価用細胞及び薬物評価方法 特許公開 特開2016-010379 2016/01/21 公開
水口 裕之, 川端 健二, 高山 和雄 水口 裕之, 川端 健二, 高山 和雄 幹細胞から肝細胞への分化誘導方法 幹細胞から肝細胞への分化誘導方法 特許公開 特開2013-252081 2013/12/19 公開
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