木下 秀之

最終更新日時: 2016/08/01 12:03:41

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氏名(漢字/フリガナ/アルファベット表記)
木下 秀之/キノシタ ヒデユキ/Kinoshita, Hideyuki
所属部署・職名(部局/所属/講座等/職名)
医学研究科/地域医療システム学講座(寄附)/特定准教授
連絡先住所
種別 住所(日本語) 住所(英語)
職場
連絡先電話番号
種別 番号
職場
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
博士(医学) 京都大学
プロフィール
(日本語)
病的心血管リモデリング発症の分子メカニズムの解明を目標として研究を行っている。また、心不全患者や肺高血圧患者の診療に従事し治療を行っている。
(英語)
My major research area is the molecular mechanism of cardiac hypertrophy dysfunction and pulmonary hypertension. Cardiac imaging such as echocardiography is also my major field. I am also undergoing treatment to the patients with heart failure and pulmonary hypertension.
researchmap URL
https://researchmap.jp/read0201552
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Yamada C, Kuwahara K, Yamazaki M, Nakagawa Y, Nishikimi T, Kinoshita H, Kuwabara Y, Minami T, Yamada Y, Shibata J, Nakao K, Cho K, Arai Y, Honjo H, Kamiya K, Nakao K, Kimura T Yamada C, Kuwahara K, Yamazaki M, Nakagawa Y, Nishikimi T, Kinoshita H, Kuwabara Y, Minami T, Yamada Y, Shibata J, Nakao K, Cho K, Arai Y, Honjo H, Kamiya K, Nakao K, Kimura T Yamada C, Kuwahara K, Yamazaki M, Nakagawa Y, Nishikimi T, Kinoshita H, Kuwabara Y, Minami T, Yamada Y, Shibata J, Nakao K, Cho K, Arai Y, Honjo H, Kamiya K, Nakao K, Kimura T The renin-angiotensin system promotes arrhythmogenic substrates and lethal arrhythmias in mice with non-ischaemic cardiomyopathy. The renin-angiotensin system promotes arrhythmogenic substrates and lethal arrhythmias in mice with non-ischaemic cardiomyopathy. The renin-angiotensin system promotes arrhythmogenic substrates and lethal arrhythmias in mice with non-ischaemic cardiomyopathy. Cardiovascular research, 109, 1, 162-173 Cardiovascular research, 109, 1, 162-173 Cardiovascular research, 109, 1, 162-173 2016/01 公開
Nishikimi T, Nakagawa Y, Minamino N, Ikeda M, Tabei K, Fujishima A, Takayama K, Akimoto K, Yamada C, Nakao K, Minami T, Kuwabara Y, Kinoshita H, Tsutamoto T, Ishimitsu T, Kangawa K, Kuwahara K, Nakao K Nishikimi T, Nakagawa Y, Minamino N, Ikeda M, Tabei K, Fujishima A, Takayama K, Akimoto K, Yamada C, Nakao K, Minami T, Kuwabara Y, Kinoshita H, Tsutamoto T, Ishimitsu T, Kangawa K, Kuwahara K, Nakao K Nishikimi T, Nakagawa Y, Minamino N, Ikeda M, Tabei K, Fujishima A, Takayama K, Akimoto K, Yamada C, Nakao K, Minami T, Kuwabara Y, Kinoshita H, Tsutamoto T, Ishimitsu T, Kangawa K, Kuwahara K, Nakao K Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites. Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites. Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites. American journal of physiology. Regulatory, integrative and comparative physiology, 309, 6, R639-49 American journal of physiology. Regulatory, integrative and comparative physiology, 309, 6, R639-49 American journal of physiology. Regulatory, integrative and comparative physiology, 309, 6, R639-49 2015/09 公開
Date H, Sato M, Aoyama A, Yamada T, Mizota T, Kinoshita H, Handa T, Tanizawa K, Chin K, Minakata K, Chen F Date H, Sato M, Aoyama A, Yamada T, Mizota T, Kinoshita H, Handa T, Tanizawa K, Chin K, Minakata K, Chen F Date H, Sato M, Aoyama A, Yamada T, Mizota T, Kinoshita H, Handa T, Tanizawa K, Chin K, Minakata K, Chen F Living-donor lobar lung transplantation provides similar survival to cadaveric lung transplantation even for very ill patients†. Living-donor lobar lung transplantation provides similar survival to cadaveric lung transplantation even for very ill patients†. Living-donor lobar lung transplantation provides similar survival to cadaveric lung transplantation even for very ill patients†. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 47, 6, 967-72; discussion 972 European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 47, 6, 967-72; discussion 972 European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 47, 6, 967-72; discussion 972 2015/06 公開
Tanaka M, Yamaguchi S, Yamazaki Y, Kinoshita H, Kuwahara K, Nakao K, Jay PY, Noda T, Nakamura T Tanaka M, Yamaguchi S, Yamazaki Y, Kinoshita H, Kuwahara K, Nakao K, Jay PY, Noda T, Nakamura T Tanaka M, Yamaguchi S, Yamazaki Y, Kinoshita H, Kuwahara K, Nakao K, Jay PY, Noda T, Nakamura T Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model. Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model. Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model. Scientific reports, 5, 7826 Scientific reports, 5, 7826 Scientific reports, 5, 7826 2015/01 公開
Yamada Y, Kinoshita H, Kuwahara K, Nakagawa Y, Kuwabara Y, Minami T, Yamada C, Shibata J, Nakao K, Cho K, Arai Y, Yasuno S, Nishikimi T, Ueshima K, Kamakura S, Nishida M, Kiyonaka S, Mori Y, Kimura T, Kangawa K, Nakao K Yamada Y, Kinoshita H, Kuwahara K, Nakagawa Y, Kuwabara Y, Minami T, Yamada C, Shibata J, Nakao K, Cho K, Arai Y, Yasuno S, Nishikimi T, Ueshima K, Kamakura S, Nishida M, Kiyonaka S, Mori Y, Kimura T, Kangawa K, Nakao K Yamada Y, Kinoshita H, Kuwahara K, Nakagawa Y, Kuwabara Y, Minami T, Yamada C, Shibata J, Nakao K, Cho K, Arai Y, Yasuno S, Nishikimi T, Ueshima K, Kamakura S, Nishida M, Kiyonaka S, Mori Y, Kimura T, Kangawa K, Nakao K Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure. Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure. Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure. Cardiovascular research, 104, 1, 183-193 Cardiovascular research, 104, 1, 183-193 Cardiovascular research, 104, 1, 183-193 2014/10 公開
Nakagawa Y, Nishikimi T, Kuwahara K, Yasuno S, Kinoshita H, Kuwabara Y, Nakao K, Minami T, Yamada C, Ueshima K, Ikeda Y, Okamoto H, Horii K, Nagata K, Kangawa K, Minamino N, Nakao K Nakagawa Y, Nishikimi T, Kuwahara K, Yasuno S, Kinoshita H, Kuwabara Y, Nakao K, Minami T, Yamada C, Ueshima K, Ikeda Y, Okamoto H, Horii K, Nagata K, Kangawa K, Minamino N, Nakao K Nakagawa Y, Nishikimi T, Kuwahara K, Yasuno S, Kinoshita H, Kuwabara Y, Nakao K, Minami T, Yamada C, Ueshima K, Ikeda Y, Okamoto H, Horii K, Nagata K, Kangawa K, Minamino N, Nakao K The effects of super-flux (high performance) dialyzer on plasma glycosylated pro-B-type natriuretic peptide (proBNP) and glycosylated N-Terminal proBNP in end-stage renal disease patients on dialysis. The effects of super-flux (high performance) dialyzer on plasma glycosylated pro-B-type natriuretic peptide (proBNP) and glycosylated N-Terminal proBNP in end-stage renal disease patients on dialysis. The effects of super-flux (high performance) dialyzer on plasma glycosylated pro-B-type natriuretic peptide (proBNP) and glycosylated N-Terminal proBNP in end-stage renal disease patients on dialysis. PloS one, 9, 3, e92314 PloS one, 9, 3, e92314 PloS one, 9, 3, e92314 2014 公開
Yoshifuji H, Kinoshita H Yoshifuji H, Kinoshita H Yoshifuji H, Kinoshita H [Management of borderline pulmonary arterial hypertension associated with connective tissue diseases]. [Management of borderline pulmonary arterial hypertension associated with connective tissue diseases]. [Management of borderline pulmonary arterial hypertension associated with connective tissue diseases]. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 37, 6, 454-461 Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 37, 6, 454-461 Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 37, 6, 454-461 2014 公開
Yasuno S, Kuwahara K, Kinoshita H, Yamada C, Nakagawa Y, Usami S, Kuwabara Y, Ueshima K, Harada M, Nishikimi T, Nakao K Yasuno S, Kuwahara K, Kinoshita H, Yamada C, Nakagawa Y, Usami S, Kuwabara Y, Ueshima K, Harada M, Nishikimi T, Nakao K Yasuno S, Kuwahara K, Kinoshita H, Yamada C, Nakagawa Y, Usami S, Kuwabara Y, Ueshima K, Harada M, Nishikimi T, Nakao K Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy. Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy. Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy. British journal of pharmacology, 170, 7, 1384-1395 British journal of pharmacology, 170, 7, 1384-1395 British journal of pharmacology, 170, 7, 1384-1395 2013/12 公開
Terao C, Yoshifuji H, Ohmura K, Murakami K, Kawabata D, Yurugi K, Tazaki J, Kinoshita H, Kimura A, Akizuki M, Kawaguchi Y, Yamanaka H, Miura Y, Maekawa T, Saji H, Mimori T, Matsuda F Terao C, Yoshifuji H, Ohmura K, Murakami K, Kawabata D, Yurugi K, Tazaki J, Kinoshita H, Kimura A, Akizuki M, Kawaguchi Y, Yamanaka H, Miura Y, Maekawa T, Saji H, Mimori T, Matsuda F Terao C, Yoshifuji H, Ohmura K, Murakami K, Kawabata D, Yurugi K, Tazaki J, Kinoshita H, Kimura A, Akizuki M, Kawaguchi Y, Yamanaka H, Miura Y, Maekawa T, Saji H, Mimori T, Matsuda F Association of Takayasu arteritis with HLA-B 67:01 and two amino acids in HLA-B protein. Association of Takayasu arteritis with HLA-B 67:01 and two amino acids in HLA-B protein. Association of Takayasu arteritis with HLA-B 67:01 and two amino acids in HLA-B protein. Rheumatology (Oxford, England), 52, 10, 1769-1774 Rheumatology (Oxford, England), 52, 10, 1769-1774 Rheumatology (Oxford, England), 52, 10, 1769-1774 2013/10 公開
Honda K, Sone M, Tamura N, Sonoyama T, Taura D, Kojima K, Fukuda Y, Tanaka S, Yasuno S, Fujii T, Kinoshita H, Ariyasu H, Kanamoto N, Miura M, Yasoda A, Arai H, Ueshima K, Nakao K Honda K, Sone M, Tamura N, Sonoyama T, Taura D, Kojima K, Fukuda Y, Tanaka S, Yasuno S, Fujii T, Kinoshita H, Ariyasu H, Kanamoto N, Miura M, Yasoda A, Arai H, Ueshima K, Nakao K Honda K, Sone M, Tamura N, Sonoyama T, Taura D, Kojima K, Fukuda Y, Tanaka S, Yasuno S, Fujii T, Kinoshita H, Ariyasu H, Kanamoto N, Miura M, Yasoda A, Arai H, Ueshima K, Nakao K Adrenal reserve function after unilateral adrenalectomy in patients with primary aldosteronism. Adrenal reserve function after unilateral adrenalectomy in patients with primary aldosteronism. Adrenal reserve function after unilateral adrenalectomy in patients with primary aldosteronism. Journal of hypertension, 31, 10, 2010-2017 Journal of hypertension, 31, 10, 2010-2017 Journal of hypertension, 31, 10, 2010-2017 2013/10 公開
Terao C, Yoshifuji H, Kimura A, Matsumura T, Ohmura K, Takahashi M, Shimizu M, Kawaguchi T, Chen Z, Naruse TK, Sato-Otsubo A, Ebana Y, Maejima Y, Kinoshita H, Murakami K, Kawabata D, Wada Y, Narita I, Tazaki J, Kawaguchi Y, Yamanaka H, Yurugi K, Miura Y, Maekawa T, Ogawa S, Komuro I, Nagai R, Yamada R, Tabara Y, Isobe M, Mimori T, Matsuda F Terao C, Yoshifuji H, Kimura A, Matsumura T, Ohmura K, Takahashi M, Shimizu M, Kawaguchi T, Chen Z, Naruse TK, Sato-Otsubo A, Ebana Y, Maejima Y, Kinoshita H, Murakami K, Kawabata D, Wada Y, Narita I, Tazaki J, Kawaguchi Y, Yamanaka H, Yurugi K, Miura Y, Maekawa T, Ogawa S, Komuro I, Nagai R, Yamada R, Tabara Y, Isobe M, Mimori T, Matsuda F Terao C, Yoshifuji H, Kimura A, Matsumura T, Ohmura K, Takahashi M, Shimizu M, Kawaguchi T, Chen Z, Naruse TK, Sato-Otsubo A, Ebana Y, Maejima Y, Kinoshita H, Murakami K, Kawabata D, Wada Y, Narita I, Tazaki J, Kawaguchi Y, Yamanaka H, Yurugi K, Miura Y, Maekawa T, Ogawa S, Komuro I, Nagai R, Yamada R, Tabara Y, Isobe M, Mimori T, Matsuda F Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population. Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population. Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population. American journal of human genetics, 93, 2, 289-297 American journal of human genetics, 93, 2, 289-297 American journal of human genetics, 93, 2, 289-297 2013/08 公開
Matsumoto E, Sasaki S, Kinoshita H, Kito T, Ohta H, Konishi M, Kuwahara K, Nakao K, Itoh N Matsumoto E, Sasaki S, Kinoshita H, Kito T, Ohta H, Konishi M, Kuwahara K, Nakao K, Itoh N Matsumoto E, Sasaki S, Kinoshita H, Kito T, Ohta H, Konishi M, Kuwahara K, Nakao K, Itoh N Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16. Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16. Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16. Genes to cells : devoted to molecular & cellular mechanisms, 18, 7, 544-553 Genes to cells : devoted to molecular & cellular mechanisms, 18, 7, 544-553 Genes to cells : devoted to molecular & cellular mechanisms, 18, 7, 544-553 2013/07 公開
Kuwabara Y, Kuwahara K, Takano M, Kinoshita H, Arai Y, Yasuno S, Nakagawa Y, Igata S, Usami S, Minami T, Yamada Y, Nakao K, Yamada C, Shibata J, Nishikimi T, Ueshima K, Nakao K Kuwabara Y, Kuwahara K, Takano M, Kinoshita H, Arai Y, Yasuno S, Nakagawa Y, Igata S, Usami S, Minami T, Yamada Y, Nakao K, Yamada C, Shibata J, Nishikimi T, Ueshima K, Nakao K Kuwabara Y, Kuwahara K, Takano M, Kinoshita H, Arai Y, Yasuno S, Nakagawa Y, Igata S, Usami S, Minami T, Yamada Y, Nakao K, Yamada C, Shibata J, Nishikimi T, Ueshima K, Nakao K Increased expression of HCN channels in the ventricular myocardium contributes to enhanced arrhythmicity in mouse failing hearts. Increased expression of HCN channels in the ventricular myocardium contributes to enhanced arrhythmicity in mouse failing hearts. Increased expression of HCN channels in the ventricular myocardium contributes to enhanced arrhythmicity in mouse failing hearts. Journal of the American Heart Association, 2, 3, e000150 Journal of the American Heart Association, 2, 3, e000150 Journal of the American Heart Association, 2, 3, e000150 2013/05 公開
Nishikimi T, Okamoto H, Nakamura M, Ogawa N, Horii K, Nagata K, Nakagawa Y, Kinoshita H, Yamada C, Nakao K, Minami T, Kuwabara Y, Kuwahara K, Masuda I, Kangawa K, Minamino N, Nakao K Nishikimi T, Okamoto H, Nakamura M, Ogawa N, Horii K, Nagata K, Nakagawa Y, Kinoshita H, Yamada C, Nakao K, Minami T, Kuwabara Y, Kuwahara K, Masuda I, Kangawa K, Minamino N, Nakao K Nishikimi T, Okamoto H, Nakamura M, Ogawa N, Horii K, Nagata K, Nakagawa Y, Kinoshita H, Yamada C, Nakao K, Minami T, Kuwabara Y, Kuwahara K, Masuda I, Kangawa K, Minamino N, Nakao K Direct immunochemiluminescent assay for proBNP and total BNP in human plasma proBNP and total BNP levels in normal and heart failure. Direct immunochemiluminescent assay for proBNP and total BNP in human plasma proBNP and total BNP levels in normal and heart failure. Direct immunochemiluminescent assay for proBNP and total BNP in human plasma proBNP and total BNP levels in normal and heart failure. PloS one, 8, 1, e53233 PloS one, 8, 1, e53233 PloS one, 8, 1, e53233 2013 公開
Minami T, Kuwahara K, Nakagawa Y, Takaoka M, Kinoshita H, Nakao K, Kuwabara Y, Yamada Y, Yamada C, Shibata J, Usami S, Yasuno S, Nishikimi T, Ueshima K, Sata M, Nakano H, Seno T, Kawahito Y, Sobue K, Kimura A, Nagai R, Nakao K Minami T, Kuwahara K, Nakagawa Y, Takaoka M, Kinoshita H, Nakao K, Kuwabara Y, Yamada Y, Yamada C, Shibata J, Usami S, Yasuno S, Nishikimi T, Ueshima K, Sata M, Nakano H, Seno T, Kawahito Y, Sobue K, Kimura A, Nagai R, Nakao K Minami T, Kuwahara K, Nakagawa Y, Takaoka M, Kinoshita H, Nakao K, Kuwabara Y, Yamada Y, Yamada C, Shibata J, Usami S, Yasuno S, Nishikimi T, Ueshima K, Sata M, Nakano H, Seno T, Kawahito Y, Sobue K, Kimura A, Nagai R, Nakao K Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice. Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice. Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice. The EMBO journal, 31, 23, 4428-4440 The EMBO journal, 31, 23, 4428-4440 The EMBO journal, 31, 23, 4428-4440 2012/11 公開
Nishikimi T, Ikeda M, Takeda Y, Ishimitsu T, Shibasaki I, Fukuda H, Kinoshita H, Nakagawa Y, Kuwahara K, Nakao K Nishikimi T, Ikeda M, Takeda Y, Ishimitsu T, Shibasaki I, Fukuda H, Kinoshita H, Nakagawa Y, Kuwahara K, Nakao K Nishikimi T, Ikeda M, Takeda Y, Ishimitsu T, Shibasaki I, Fukuda H, Kinoshita H, Nakagawa Y, Kuwahara K, Nakao K The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure. The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure. The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure. Heart (British Cardiac Society), 98, 2, 152-161 Heart (British Cardiac Society), 98, 2, 152-161 Heart (British Cardiac Society), 98, 2, 152-161 2012/01 公開
Shimizu K, Kawakami S, Hayashi K, Kinoshita H, Kuwahara K, Nakao K, Hashida M, Konishi S Shimizu K, Kawakami S, Hayashi K, Kinoshita H, Kuwahara K, Nakao K, Hashida M, Konishi S Shimizu K, Kawakami S, Hayashi K, Kinoshita H, Kuwahara K, Nakao K, Hashida M, Konishi S In vivo site-specific transfection of naked plasmid DNA and siRNAs in mice by using a tissue suction device. In vivo site-specific transfection of naked plasmid DNA and siRNAs in mice by using a tissue suction device. In vivo site-specific transfection of naked plasmid DNA and siRNAs in mice by using a tissue suction device. PloS one, 7, 7, e41319 PloS one, 7, 7, e41319 PloS one, 7, 7, e41319 2012 公開
Hata L, Murakami M, Kuwahara K, Nakagawa Y, Kinoshita H, Usami S, Yasuno S, Fujiwara M, Kuwabara Y, Minami T, Yamada Y, Yamada C, Nakao K, Ueshima K, Nishikimi T, Nakao K Hata L, Murakami M, Kuwahara K, Nakagawa Y, Kinoshita H, Usami S, Yasuno S, Fujiwara M, Kuwabara Y, Minami T, Yamada Y, Yamada C, Nakao K, Ueshima K, Nishikimi T, Nakao K Hata L, Murakami M, Kuwahara K, Nakagawa Y, Kinoshita H, Usami S, Yasuno S, Fujiwara M, Kuwabara Y, Minami T, Yamada Y, Yamada C, Nakao K, Ueshima K, Nishikimi T, Nakao K Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes. Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes. Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes. Journal of molecular and cellular cardiology, 50, 6, 972-981 Journal of molecular and cellular cardiology, 50, 6, 972-981 Journal of molecular and cellular cardiology, 50, 6, 972-981 2011/06 公開
Kuwahara K, Kinoshita H, Kuwabara Y, Nakagawa Y, Usami S, Minami T, Yamada Y, Fujiwara M, Nakao K Kuwahara K, Kinoshita H, Kuwabara Y, Nakagawa Y, Usami S, Minami T, Yamada Y, Fujiwara M, Nakao K Kuwahara K, Kinoshita H, Kuwabara Y, Nakagawa Y, Usami S, Minami T, Yamada Y, Fujiwara M, Nakao K Myocardin-related transcription factor A is a common mediator of mechanical stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression. Myocardin-related transcription factor A is a common mediator of mechanical stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression. Myocardin-related transcription factor A is a common mediator of mechanical stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression. Molecular and cellular biology, 30, 17, 4134-4148 Molecular and cellular biology, 30, 17, 4134-4148 Molecular and cellular biology, 30, 17, 4134-4148 2010/09 公開
Small EM, Thatcher JE, Sutherland LB, Kinoshita H, Gerard RD, Richardson JA, Dimaio JM, Sadek H, Kuwahara K, Olson EN Small EM, Thatcher JE, Sutherland LB, Kinoshita H, Gerard RD, Richardson JA, Dimaio JM, Sadek H, Kuwahara K, Olson EN Small EM, Thatcher JE, Sutherland LB, Kinoshita H, Gerard RD, Richardson JA, Dimaio JM, Sadek H, Kuwahara K, Olson EN Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction. Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction. Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction. Circulation research, 107, 2, 294-304 Circulation research, 107, 2, 294-304 Circulation research, 107, 2, 294-304 2010/07 公開
Kinoshita H, Kuwahara K, Nishida M, Jian Z, Rong X, Kiyonaka S, Kuwabara Y, Kurose H, Inoue R, Mori Y, Li Y, Nakagawa Y, Usami S, Fujiwara M, Yamada Y, Minami T, Ueshima K, Nakao K Kinoshita H, Kuwahara K, Nishida M, Jian Z, Rong X, Kiyonaka S, Kuwabara Y, Kurose H, Inoue R, Mori Y, Li Y, Nakagawa Y, Usami S, Fujiwara M, Yamada Y, Minami T, Ueshima K, Nakao K Kinoshita H, Kuwahara K, Nishida M, Jian Z, Rong X, Kiyonaka S, Kuwabara Y, Kurose H, Inoue R, Mori Y, Li Y, Nakagawa Y, Usami S, Fujiwara M, Yamada Y, Minami T, Ueshima K, Nakao K Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart. Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart. Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart. Circulation research, 106, 12, 1849-1860 Circulation research, 106, 12, 1849-1860 Circulation research, 106, 12, 1849-1860 2010/06 公開
Nakagawa Y, Kuwahara K, Takemura G, Akao M, Kato M, Arai Y, Takano M, Harada M, Murakami M, Nakanishi M, Usami S, Yasuno S, Kinoshita H, Fujiwara M, Ueshima K, Nakao K Nakagawa Y, Kuwahara K, Takemura G, Akao M, Kato M, Arai Y, Takano M, Harada M, Murakami M, Nakanishi M, Usami S, Yasuno S, Kinoshita H, Fujiwara M, Ueshima K, Nakao K Nakagawa Y, Kuwahara K, Takemura G, Akao M, Kato M, Arai Y, Takano M, Harada M, Murakami M, Nakanishi M, Usami S, Yasuno S, Kinoshita H, Fujiwara M, Ueshima K, Nakao K p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts. p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts. p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts. Circulation research, 105, 8, 746-754 Circulation research, 105, 8, 746-754 Circulation research, 105, 8, 746-754 2009/10 公開
Kinoshita H, Kuwahara K, Takano M, Arai Y, Kuwabara Y, Yasuno S, Nakagawa Y, Nakanishi M, Harada M, Fujiwara M, Murakami M, Ueshima K, Nakao K Kinoshita H, Kuwahara K, Takano M, Arai Y, Kuwabara Y, Yasuno S, Nakagawa Y, Nakanishi M, Harada M, Fujiwara M, Murakami M, Ueshima K, Nakao K Kinoshita H, Kuwahara K, Takano M, Arai Y, Kuwabara Y, Yasuno S, Nakagawa Y, Nakanishi M, Harada M, Fujiwara M, Murakami M, Ueshima K, Nakao K T-type Ca2+ channel blockade prevents sudden death in mice with heart failure. T-type Ca2+ channel blockade prevents sudden death in mice with heart failure. T-type Ca2+ channel blockade prevents sudden death in mice with heart failure. Circulation, 120, 9, 743-752 Circulation, 120, 9, 743-752 Circulation, 120, 9, 743-752 2009/09 公開
Li Y, Saito Y, Kuwahara K, Rong X, Kishimoto I, Harada M, Adachi Y, Nakanishi M, Kinoshita H, Horiuchi M, Murray M, Nakao K Li Y, Saito Y, Kuwahara K, Rong X, Kishimoto I, Harada M, Adachi Y, Nakanishi M, Kinoshita H, Horiuchi M, Murray M, Nakao K Li Y, Saito Y, Kuwahara K, Rong X, Kishimoto I, Harada M, Adachi Y, Nakanishi M, Kinoshita H, Horiuchi M, Murray M, Nakao K Guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart. Guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart. Guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart. Endocrinology, 150, 8, 3759-3765 Endocrinology, 150, 8, 3759-3765 Endocrinology, 150, 8, 3759-3765 2009/08 公開
Yasuno S, Usami S, Kuwahara K, Nakanishi M, Arai Y, Kinoshita H, Nakagawa Y, Fujiwara M, Murakami M, Ueshima K, Harada M, Nakao K Yasuno S, Usami S, Kuwahara K, Nakanishi M, Arai Y, Kinoshita H, Nakagawa Y, Fujiwara M, Murakami M, Ueshima K, Harada M, Nakao K Yasuno S, Usami S, Kuwahara K, Nakanishi M, Arai Y, Kinoshita H, Nakagawa Y, Fujiwara M, Murakami M, Ueshima K, Harada M, Nakao K Endogenous cardiac natriuretic peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death. Endogenous cardiac natriuretic peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death. Endogenous cardiac natriuretic peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death. American journal of physiology. Heart and circulatory physiology, 296, 6, H1804-10 American journal of physiology. Heart and circulatory physiology, 296, 6, H1804-10 American journal of physiology. Heart and circulatory physiology, 296, 6, H1804-10 2009/06 公開
Hotta Y, Sasaki S, Konishi M, Kinoshita H, Kuwahara K, Nakao K, Itoh N Hotta Y, Sasaki S, Konishi M, Kinoshita H, Kuwahara K, Nakao K, Itoh N Hotta Y, Sasaki S, Konishi M, Kinoshita H, Kuwahara K, Nakao K, Itoh N Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart. Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart. Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart. Developmental dynamics : an official publication of the American Association of Anatomists, 237, 10, 2947-2954 Developmental dynamics : an official publication of the American Association of Anatomists, 237, 10, 2947-2954 Developmental dynamics : an official publication of the American Association of Anatomists, 237, 10, 2947-2954 2008/10 公開
Nakanishi M, Harada M, Kishimoto I, Kuwahara K, Kawakami R, Nakagawa Y, Yasuno S, Usami S, Kinoshita H, Adachi Y, Fukamizu A, Saito Y, Nakao K Nakanishi M, Harada M, Kishimoto I, Kuwahara K, Kawakami R, Nakagawa Y, Yasuno S, Usami S, Kinoshita H, Adachi Y, Fukamizu A, Saito Y, Nakao K Nakanishi M, Harada M, Kishimoto I, Kuwahara K, Kawakami R, Nakagawa Y, Yasuno S, Usami S, Kinoshita H, Adachi Y, Fukamizu A, Saito Y, Nakao K Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation. Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation. Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation. Circulation journal : official journal of the Japanese Circulation Society, 71, 8, 1310-1316 Circulation journal : official journal of the Japanese Circulation Society, 71, 8, 1310-1316 Circulation journal : official journal of the Japanese Circulation Society, 71, 8, 1310-1316 2007/08 公開
Nakanishi M, Harada M, Tadamura E, Kotani H, Kawakami R, Kuwahara K, Nakagawa Y, Usami S, Kinoshita H, Fujiwara M, Hosoda K, Ueshima K, Nakao K Nakanishi M, Harada M, Tadamura E, Kotani H, Kawakami R, Kuwahara K, Nakagawa Y, Usami S, Kinoshita H, Fujiwara M, Hosoda K, Ueshima K, Nakao K Nakanishi M, Harada M, Tadamura E, Kotani H, Kawakami R, Kuwahara K, Nakagawa Y, Usami S, Kinoshita H, Fujiwara M, Hosoda K, Ueshima K, Nakao K Images in cardiovascular medicine. Mitochondrial cardiomyopathy evaluated with cardiac magnetic resonance. Images in cardiovascular medicine. Mitochondrial cardiomyopathy evaluated with cardiac magnetic resonance. Images in cardiovascular medicine. Mitochondrial cardiomyopathy evaluated with cardiac magnetic resonance. Circulation, 116, 2, e25-6 Circulation, 116, 2, e25-6 Circulation, 116, 2, e25-6 2007/07 公開
Yasuda S, Miyazaki S, Kinoshita H, Nagaya N, Kanda M, Goto Y, Nonogi H Yasuda S, Miyazaki S, Kinoshita H, Nagaya N, Kanda M, Goto Y, Nonogi H Yasuda S, Miyazaki S, Kinoshita H, Nagaya N, Kanda M, Goto Y, Nonogi H Enhanced cardiac production of matrix metalloproteinase-2 and -9 and its attenuation associated with pravastatin treatment in patients with acute myocardial infarction. Enhanced cardiac production of matrix metalloproteinase-2 and -9 and its attenuation associated with pravastatin treatment in patients with acute myocardial infarction. Enhanced cardiac production of matrix metalloproteinase-2 and -9 and its attenuation associated with pravastatin treatment in patients with acute myocardial infarction. Clinical science (London, England : 1979), 112, 1, 43-49 Clinical science (London, England : 1979), 112, 1, 43-49 Clinical science (London, England : 1979), 112, 1, 43-49 2007/01 公開
Nakagawa Y, Kuwahara K, Harada M, Takahashi N, Yasuno S, Adachi Y, Kawakami R, Nakanishi M, Tanimoto K, Usami S, Kinoshita H, Saito Y, Nakao K Nakagawa Y, Kuwahara K, Harada M, Takahashi N, Yasuno S, Adachi Y, Kawakami R, Nakanishi M, Tanimoto K, Usami S, Kinoshita H, Saito Y, Nakao K Nakagawa Y, Kuwahara K, Harada M, Takahashi N, Yasuno S, Adachi Y, Kawakami R, Nakanishi M, Tanimoto K, Usami S, Kinoshita H, Saito Y, Nakao K Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes. Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes. Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes. Journal of molecular and cellular cardiology, 41, 6, 1010-1022 Journal of molecular and cellular cardiology, 41, 6, 1010-1022 Journal of molecular and cellular cardiology, 41, 6, 1010-1022 2006/12 公開
Kawakami R, Saito Y, Kishimoto I, Harada M, Kuwahara K, Takahashi N, Nakagawa Y, Nakanishi M, Tanimoto K, Usami S, Yasuno S, Kinoshita H, Chusho H, Tamura N, Ogawa Y, Nakao K Kawakami R, Saito Y, Kishimoto I, Harada M, Kuwahara K, Takahashi N, Nakagawa Y, Nakanishi M, Tanimoto K, Usami S, Yasuno S, Kinoshita H, Chusho H, Tamura N, Ogawa Y, Nakao K Kawakami R, Saito Y, Kishimoto I, Harada M, Kuwahara K, Takahashi N, Nakagawa Y, Nakanishi M, Tanimoto K, Usami S, Yasuno S, Kinoshita H, Chusho H, Tamura N, Ogawa Y, Nakao K Overexpression of brain natriuretic peptide facilitates neutrophil infiltration and cardiac matrix metalloproteinase-9 expression after acute myocardial infarction. Overexpression of brain natriuretic peptide facilitates neutrophil infiltration and cardiac matrix metalloproteinase-9 expression after acute myocardial infarction. Overexpression of brain natriuretic peptide facilitates neutrophil infiltration and cardiac matrix metalloproteinase-9 expression after acute myocardial infarction. Circulation, 110, 21, 3306-3312 Circulation, 110, 21, 3306-3312 Circulation, 110, 21, 3306-3312 2004/11 公開
Kuwahara K, Saito Y, Takano M, Arai Y, Yasuno S, Nakagawa Y, Takahashi N, Adachi Y, Takemura G, Horie M, Miyamoto Y, Morisaki T, Kuratomi S, Noma A, Fujiwara H, Yoshimasa Y, Kinoshita H, Kawakami R, Kishimoto I, Nakanishi M, Usami S, Saito Y, Harada M, Nakao K Kuwahara K, Saito Y, Takano M, Arai Y, Yasuno S, Nakagawa Y, Takahashi N, Adachi Y, Takemura G, Horie M, Miyamoto Y, Morisaki T, Kuratomi S, Noma A, Fujiwara H, Yoshimasa Y, Kinoshita H, Kawakami R, Kishimoto I, Nakanishi M, Usami S, Saito Y, Harada M, Nakao K Kuwahara K, Saito Y, Takano M, Arai Y, Yasuno S, Nakagawa Y, Takahashi N, Adachi Y, Takemura G, Horie M, Miyamoto Y, Morisaki T, Kuratomi S, Noma A, Fujiwara H, Yoshimasa Y, Kinoshita H, Kawakami R, Kishimoto I, Nakanishi M, Usami S, Saito Y, Harada M, Nakao K NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function. NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function. NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function. The EMBO journal, 22, 23, 6310-6321 The EMBO journal, 22, 23, 6310-6321 The EMBO journal, 22, 23, 6310-6321 2003/12 公開

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タイトル言語:
外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
若手研究(B) 病的心筋リモデリングにおける新規治療標的としてのTRPCチャンネルの意義の解明 2008〜2009
若手研究(B) 心筋リモデリングにおけるTRPC3/6を介したシグナルクロストークの意義の解明 2010〜2011
基盤研究(C) 代表 心不全発症・進展における新規治療標的としてのTRPC6/3の意義の解明 2012〜2014
基盤研究(C) 代表 心不全発症・進展における新規治療標的としてのTRPC6/3の意義の解明 (平成26年度分) 2014/04/01〜2015/03/31