笹沼 博之

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氏名(漢字／フリガナ／アルファベット表記)
笹沼 博之／ササヌマ ヒロユキ／Sasanuma, Hiroyuki
所属部署・職名(部局／所属／講座等／職名)
医学研究科／医学専攻遺伝医学講座放射線遺伝学／准教授
学部兼担
部局 所属 講座等 職名
医学部
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士（理学） 大阪大学
博士（理学） 埼玉大学
researchmap URL
https://researchmap.jp/7000009079
研究テーマ
(日本語)
DNA二重鎖切断修復機構の解明
(英語)
Elucidation of the mechanism regulating DNA double-strand break repair.
研究概要
(日本語)
DNA 二重鎖切断(DSB)は、DNA損傷の中でも最も重篤な損傷であり、正確に修復される必要がある。DSB修復異常は、がんを引き起こす。DSB修復の分子機構は分かっていないことが多い。ゲノム改変細胞を用いた遺伝学的、生化学的解析を通して、DSB修復機構のメカニズム解明を目指している。
(英語)
DNA double-strand breaks (DSBs) are serious lesions that threaten a loss of chromosomal content. Failure in DSB repair could lead to genomic instability and cancer. My research focuses on the investigation of molecular mechanism of how the DSBs are repaired through biochemical and genetics approaches.
研究分野（キーワード）
キーワード(日本語) キーワード(英語)
トポイソメラーゼ2型酵素 Topoisomerase 2
DNA二重鎖切断修復 DNA double-strand break
BRCA変異 BRCA mutation
がん Cancer
放射線 Ionizing radiation
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, Durocher D, Nussenzweig A. Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, Durocher D, Nussenzweig A. Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, Durocher D, Nussenzweig A. BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation. BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation. BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation. Molecular Cell, in press Molecular Cell, in press Molecular Cell, in press 2019/01 有 英語 研究論文(学術雑誌) 公開
Mohiuddin, Evans, T.J., Rahman, M.M.,Keka, I.S.,Tsuda, M., Sasanuma, H., Takeda, S. Mohiuddin, Evans, T.J., Rahman, M.M.,Keka, I.S.,Tsuda, M., Sasanuma, H., Takeda, S. Mohiuddin, Evans, T.J., Rahman, M.M.,Keka, I.S.,Tsuda, M., Sasanuma, H., Takeda, S. SUMOylation of PCNA by PIAS1 and PIAS4 promotes template switch in the chicken and human B cell lines SUMOylation of PCNA by PIAS1 and PIAS4 promotes template switch in the chicken and human B cell lines SUMOylation of PCNA by PIAS1 and PIAS4 promotes template switch in the chicken and human B cell lines Proceeding of National Academy of Sciences, 115, 50, 12793-12798 Proceeding of National Academy of Sciences, 115, 50, 12793-12798 Proceeding of National Academy of Sciences, 115, 50, 12793-12798 2018/11 有 英語 研究論文(学術雑誌) 公開
Sasanuma H1, Tsuda M2,3, Morimoto S2, Saha LK2, Rahman MM2, Kiyooka Y, Fujiike H, Cherniack AD, Itou J, Callen Moreu E, Toi M, Nakada S, Tanaka H, Tsutsui K, Yamada S, Nussenzweig A, Takeda S. Sasanuma H1, Tsuda M2,3, Morimoto S2, Saha LK2, Rahman MM2, Kiyooka Y, Fujiike H, Cherniack AD, Itou J, Callen Moreu E, Toi M, Nakada S, Tanaka H, Tsutsui K, Yamada S, Nussenzweig A, Takeda S. BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes. BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes. BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II–DNA complexes Proceeding of National Academy of Sciences, 115, 45, E10642-E10651 Proceeding of National Academy of Sciences, 115, 45, E10642-E10651 Proceeding of National Academy of Sciences, 115, 45, E10642-E10651 2018/10 有 英語 研究論文(学術雑誌) 公開
Saha LK, Kim S, Kang H, Akter S, Choi K, Sakuma T, Yamamoto T, Sasanuma H, Hirota K, Nakamura J, Honma M, Takeda S, Dertinger S Saha LK, Kim S, Kang H, Akter S, Choi K, Sakuma T, Yamamoto T, Sasanuma H, Hirota K, Nakamura J, Honma M, Takeda S, Dertinger S Saha LK, Kim S, Kang H, Akter S, Choi K, Sakuma T, Yamamoto T, Sasanuma H, Hirota K, Nakamura J, Honma M, Takeda S, Dertinger S Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms. Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms. Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms. Environmental and molecular mutagenesis, 59, 6, 529-538 Environmental and molecular mutagenesis, 59, 6, 529-538 Environmental and molecular mutagenesis, 59, 6, 529-538 2018/07 有 公開
Sanada Y, Sasanuma H, Takeda S, Tano K, Masunaga SI Sanada Y, Sasanuma H, Takeda S, Tano K, Masunaga SI Sanada Y, Sasanuma H, Takeda S, Tano K, Masunaga SI Disruption of Hif-1α enhances cytotoxic effects of metformin in murine squamous cell carcinoma. Disruption of Hif-1α enhances cytotoxic effects of metformin in murine squamous cell carcinoma. Disruption of Hif-1α enhances cytotoxic effects of metformin in murine squamous cell carcinoma. International journal of radiation biology, 94, 1, 88-96 International journal of radiation biology, 94, 1, 88-96 International journal of radiation biology, 94, 1, 88-96 2018/01 有 公開
Al Abo M, Sasanuma H, Liu X, Rajapakse VN, Huang SY, Kiselev E, Takeda S, Plunkett W, Pommier Y Al Abo M, Sasanuma H, Liu X, Rajapakse VN, Huang SY, Kiselev E, Takeda S, Plunkett W, Pommier Y Al Abo M, Sasanuma H, Liu X, Rajapakse VN, Huang SY, Kiselev E, Takeda S, Plunkett W, Pommier Y TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors. TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors. TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors. Molecular cancer therapeutics, 16, 11, 2543-2551 Molecular cancer therapeutics, 16, 11, 2543-2551 Molecular cancer therapeutics, 16, 11, 2543-2551 2017/11 有 公開
Çaglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC, Wilson SH Çaglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC, Wilson SH Çaglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC, Wilson SH Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts. Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts. Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts. Nucleic acids research, 45, 17, 10079-10088 Nucleic acids research, 45, 17, 10079-10088 Nucleic acids research, 45, 17, 10079-10088 2017/09 有 公開
Tsuda M, Terada K, Ooka M, Kobayashi K, Sasanuma H, Fujisawa R, Tsurimoto T, Yamamoto J, Iwai S, Kadoda K, Akagawa R, Huang SN, Pommier Y, Sale JE, Takeda S, Hirota K Tsuda M, Terada K, Ooka M, Kobayashi K, Sasanuma H, Fujisawa R, Tsurimoto T, Yamamoto J, Iwai S, Kadoda K, Akagawa R, Huang SN, Pommier Y, Sale JE, Takeda S, Hirota K Tsuda M, Terada K, Ooka M, Kobayashi K, Sasanuma H, Fujisawa R, Tsurimoto T, Yamamoto J, Iwai S, Kadoda K, Akagawa R, Huang SN, Pommier Y, Sale JE, Takeda S, Hirota K The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C). The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C). The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C). Oncotarget, 8, 20, 33457-33474 Oncotarget, 8, 20, 33457-33474 Oncotarget, 8, 20, 33457-33474 2017/05 有 公開
Moriwaki T, Okamoto S, Sasanuma H, Nagasawa H, Takeda S, Masunaga SI, Tano K Moriwaki T, Okamoto S, Sasanuma H, Nagasawa H, Takeda S, Masunaga SI, Tano K Moriwaki T, Okamoto S, Sasanuma H, Nagasawa H, Takeda S, Masunaga SI, Tano K Cytotoxicity of Tirapazamine (3-Amino-1,2,4-benzotriazine-1,4-dioxide)-Induced DNA Damage in Chicken DT40 Cells. Cytotoxicity of Tirapazamine (3-Amino-1,2,4-benzotriazine-1,4-dioxide)-Induced DNA Damage in Chicken DT40 Cells. Cytotoxicity of Tirapazamine (3-Amino-1,2,4-benzotriazine-1,4-dioxide)-Induced DNA Damage in Chicken DT40 Cells. Chemical research in toxicology, 30, 2, 699-704 Chemical research in toxicology, 30, 2, 699-704 Chemical research in toxicology, 30, 2, 699-704 2017/02 有 公開
Kadoda K, Moriwaki T, Tsuda M, Sasanuma H, Ishiai M, Takata M, Ide H, Masunaga SI, Takeda S, Tano K Kadoda K, Moriwaki T, Tsuda M, Sasanuma H, Ishiai M, Takata M, Ide H, Masunaga SI, Takeda S, Tano K Kadoda K, Moriwaki T, Tsuda M, Sasanuma H, Ishiai M, Takata M, Ide H, Masunaga SI, Takeda S, Tano K Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells. Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells. Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells. PloS one, 12, 9, e0185141 PloS one, 12, 9, e0185141 PloS one, 12, 9, e0185141 2017 有 公開
Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes. Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes. Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes. Molecular cell, 64, 5, 1010 Molecular cell, 64, 5, 1010 Molecular cell, 64, 5, 1010 2016/12 有 公開
Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes. Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes. Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes. Molecular cell, 64, 3, 580-592 Molecular cell, 64, 3, 580-592 Molecular cell, 64, 3, 580-592 2016/11 有 公開
Hashimoto K, Sharma V, Sasanuma H, Tian X, Takata M, Takeda S, Swenberg JA, Nakamura J Hashimoto K, Sharma V, Sasanuma H, Tian X, Takata M, Takeda S, Swenberg JA, Nakamura J Hashimoto K, Sharma V, Sasanuma H, Tian X, Takata M, Takeda S, Swenberg JA, Nakamura J Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells. Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells. Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells. Oncotarget, 7, 37, 59795-59808 Oncotarget, 7, 37, 59795-59808 Oncotarget, 7, 37, 59795-59808 2016/09 有 公開
Takeda S, Hoa NN, Sasanuma H Takeda S, Hoa NN, Sasanuma H Takeda S, Hoa NN, Sasanuma H The role of the Mre11-Rad50-Nbs1 complex in double-strand break repair-facts and myths. The role of the Mre11-Rad50-Nbs1 complex in double-strand break repair-facts and myths. The role of the Mre11-Rad50-Nbs1 complex in double-strand break repair-facts and myths. Journal of radiation research, 57 Suppl 1, i25-i32 Journal of radiation research, 57 Suppl 1, i25-i32 Journal of radiation research, 57 Suppl 1, i25-i32 2016/08 有 公開
Marchand C, Abdelmalak M, Kankanala J, Huang SY, Kiselev E, Fesen K, Kurahashi K, Sasanuma H, Takeda S, Aihara H, Wang Z, Pommier Y Marchand C, Abdelmalak M, Kankanala J, Huang SY, Kiselev E, Fesen K, Kurahashi K, Sasanuma H, Takeda S, Aihara H, Wang Z, Pommier Y Marchand C, Abdelmalak M, Kankanala J, Huang SY, Kiselev E, Fesen K, Kurahashi K, Sasanuma H, Takeda S, Aihara H, Wang Z, Pommier Y Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2. Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2. Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2. ACS chemical biology, 11, 7, 1925-1933 ACS chemical biology, 11, 7, 1925-1933 ACS chemical biology, 11, 7, 1925-1933 2016/07 有 公開
Mohiuddin, Kobayashi S, Keka IS, Guilbaud G, Sale J, Narita T, Abdel-Aziz HI, Wang X, Ogawa S, Sasanuma H, Chiu R, Oestergaard VH, Lisby M, Takeda S Mohiuddin, Kobayashi S, Keka IS, Guilbaud G, Sale J, Narita T, Abdel-Aziz HI, Wang X, Ogawa S, Sasanuma H, Chiu R, Oestergaard VH, Lisby M, Takeda S Mohiuddin, Kobayashi S, Keka IS, Guilbaud G, Sale J, Narita T, Abdel-Aziz HI, Wang X, Ogawa S, Sasanuma H, Chiu R, Oestergaard VH, Lisby M, Takeda S The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line. The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line. The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line. DNA repair, 40, 67-76 DNA repair, 40, 67-76 DNA repair, 40, 67-76 2016/04 有 公開
Hoa NN, Akagawa R, Yamasaki T, Hirota K, Sasa K, Natsume T, Kobayashi J, Sakuma T, Yamamoto T, Komatsu K, Kanemaki MT, Pommier Y, Takeda S, Sasanuma H Hoa NN, Akagawa R, Yamasaki T, Hirota K, Sasa K, Natsume T, Kobayashi J, Sakuma T, Yamamoto T, Komatsu K, Kanemaki MT, Pommier Y, Takeda S, Sasanuma H Hoa NN, Akagawa R, Yamasaki T, Hirota K, Sasa K, Natsume T, Kobayashi J, Sakuma T, Yamamoto T, Komatsu K, Kanemaki MT, Pommier Y, Takeda S, Sasanuma H Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines. Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines. Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines. Genes to cells : devoted to molecular & cellular mechanisms, 20, 12, 1059-1076 Genes to cells : devoted to molecular & cellular mechanisms, 20, 12, 1059-1076 Genes to cells : devoted to molecular & cellular mechanisms, 20, 12, 1059-1076 2015/12 有 公開
Keka IS, Mohiuddin, Maede Y, Rahman MM, Sakuma T, Honma M, Yamamoto T, Takeda S, Sasanuma H Keka IS, Mohiuddin, Maede Y, Rahman MM, Sakuma T, Honma M, Yamamoto T, Takeda S, Sasanuma H Keka IS, Mohiuddin, Maede Y, Rahman MM, Sakuma T, Honma M, Yamamoto T, Takeda S, Sasanuma H Smarcal1 promotes double-strand-break repair by nonhomologous end-joining. Smarcal1 promotes double-strand-break repair by nonhomologous end-joining. Smarcal1 promotes double-strand-break repair by nonhomologous end-joining. Nucleic acids research, 43, 13, 6359-6372 Nucleic acids research, 43, 13, 6359-6372 Nucleic acids research, 43, 13, 6359-6372 2015/07 有 公開
Tada K, Kobayashi M, Takiuchi Y, Iwai F, Sakamoto T, Nagata K, Shinohara M, Io K, Shirakawa K, Hishizawa M, Shindo K, Kadowaki N, Hirota K, Yamamoto J, Iwai S, Sasanuma H, Takeda S, Takaori-Kondo A Tada K, Kobayashi M, Takiuchi Y, Iwai F, Sakamoto T, Nagata K, Shinohara M, Io K, Shirakawa K, Hishizawa M, Shindo K, Kadowaki N, Hirota K, Yamamoto J, Iwai S, Sasanuma H, Takeda S, Takaori-Kondo A Tada K, Kobayashi M, Takiuchi Y, Iwai F, Sakamoto T, Nagata K, Shinohara M, Io K, Shirakawa K, Hishizawa M, Shindo K, Kadowaki N, Hirota K, Yamamoto J, Iwai S, Sasanuma H, Takeda S, Takaori-Kondo A Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia. Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia. Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia. Science advances, 1, 3, e1400203 Science advances, 1, 3, e1400203 Science advances, 1, 3, e1400203 2015/04 有 公開
Hoa NN, Kobayashi J, Omura M, Hirakawa M, Yang SH, Komatsu K, Paull TT, Takeda S, Sasanuma H Hoa NN, Kobayashi J, Omura M, Hirakawa M, Yang SH, Komatsu K, Paull TT, Takeda S, Sasanuma H Hoa NN, Kobayashi J, Omura M, Hirakawa M, Yang SH, Komatsu K, Paull TT, Takeda S, Sasanuma H BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination. BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination. BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination. PloS one, 10, 4, e0124495 PloS one, 10, 4, e0124495 PloS one, 10, 4, e0124495 2015 有 公開
Hirota K, Tsuda M, Murai J, Takagi T, Keka IS, Narita T, Fujita M, Sasanuma H, Kobayashi J, Takeda S Hirota K, Tsuda M, Murai J, Takagi T, Keka IS, Narita T, Fujita M, Sasanuma H, Kobayashi J, Takeda S Hirota K, Tsuda M, Murai J, Takagi T, Keka IS, Narita T, Fujita M, Sasanuma H, Kobayashi J, Takeda S SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss. SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss. SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss. Genes to cells : devoted to molecular & cellular mechanisms, 19, 10, 743-754 Genes to cells : devoted to molecular & cellular mechanisms, 19, 10, 743-754 Genes to cells : devoted to molecular & cellular mechanisms, 19, 10, 743-754 2014/10 有 公開
Okamoto S, Narita T, Sasanuma H, Takeda S, Masunaga S, Bessho T, Tano K Okamoto S, Narita T, Sasanuma H, Takeda S, Masunaga S, Bessho T, Tano K Okamoto S, Narita T, Sasanuma H, Takeda S, Masunaga S, Bessho T, Tano K Impact of DNA repair pathways on the cytotoxicity of piperlongumine in chicken DT40 cell-lines. Impact of DNA repair pathways on the cytotoxicity of piperlongumine in chicken DT40 cell-lines. Impact of DNA repair pathways on the cytotoxicity of piperlongumine in chicken DT40 cell-lines. Genes & cancer, 5, 7-8, 285-292 Genes & cancer, 5, 7-8, 285-292 Genes & cancer, 5, 7-8, 285-292 2014/07 有 公開
H. Sasanuma; Y. Furihata; M. Shinohara; A. Shinohara H. Sasanuma; Y. Furihata; M. Shinohara; A. Shinohara H. Sasanuma; Y. Furihata; M. Shinohara; A. Shinohara Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicase Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicase Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicase Genetics, 194, 4, 859-872 Genetics, 194, 4, 859-872 Genetics, 194, 4, 859-872 2013/08 有 英語 公開
M. Fujita; H. Sasanuma; K.N. Yamamoto; H. Harada; A. Kurosawa; N. Adachi; M. Omura; M. Hiraoka; S. Takeda; K. Hirota M. Fujita; H. Sasanuma; K.N. Yamamoto; H. Harada; A. Kurosawa; N. Adachi; M. Omura; M. Hiraoka; S. Takeda; K. Hirota M. Fujita; H. Sasanuma; K.N. Yamamoto; H. Harada; A. Kurosawa; N. Adachi; M. Omura; M. Hiraoka; S. Takeda; K. Hirota Interference in DNA Replication Can Cause Mitotic Chromosomal Breakage Unassociated with Double-Strand Breaks Interference in DNA Replication Can Cause Mitotic Chromosomal Breakage Unassociated with Double-Strand Breaks Interference in DNA Replication Can Cause Mitotic Chromosomal Breakage Unassociated with Double-Strand Breaks PLoS ONE, 8, 4, e60043 PLoS ONE, 8, 4, e60043 PLoS ONE, 8, 4, e60043 2013 有 英語 公開
H. Sasanuma; M.S. Tawaramoto; J.P. Lao; H. Hosaka; E. Sanda; M. Suzuki; E. Yamashita; N. Hunter; M. Shinohara; A. Nakagawa; A. Shinohara H. Sasanuma; M.S. Tawaramoto; J.P. Lao; H. Hosaka; E. Sanda; M. Suzuki; E. Yamashita; N. Hunter; M. Shinohara; A. Nakagawa; A. Shinohara H. Sasanuma; M.S. Tawaramoto; J.P. Lao; H. Hosaka; E. Sanda; M. Suzuki; E. Yamashita; N. Hunter; M. Shinohara; A. Nakagawa; A. Shinohara A new protein complex promoting the assembly of Rad51 filaments A new protein complex promoting the assembly of Rad51 filaments A new protein complex promoting the assembly of Rad51 filaments Nature Communications, 4, 1676 Nature Communications, 4, 1676 Nature Communications, 4, 1676 2013 有 英語 公開
Kugou K, Fukuda T, Yamada S, Ito M, Sasanuma H, Mori S, Katou Y, Itoh T, Matsumoto K, Shibata T, Shirahige K, Ohta K Kugou K, Fukuda T, Yamada S, Ito M, Sasanuma H, Mori S, Katou Y, Itoh T, Matsumoto K, Shibata T, Shirahige K, Ohta K Kugou K, Fukuda T, Yamada S, Ito M, Sasanuma H, Mori S, Katou Y, Itoh T, Matsumoto K, Shibata T, Shirahige K, Ohta K Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes. Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes. Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes. Molecular biology of the cell, 20, 13, 3064-3076 Molecular biology of the cell, 20, 13, 3064-3076 Molecular biology of the cell, 20, 13, 3064-3076 2009/07 有 公開
H. Sasanuma; K. Ohta H. Sasanuma; K. Ohta H. Sasanuma; K. Ohta [Formation of DNA double-strand breaks in meiosis]. [Formation of DNA double-strand breaks in meiosis]. [Formation of DNA double-strand breaks in meiosis]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 4 Suppl, 459-465 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 4 Suppl, 459-465 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 4 Suppl, 459-465 2009/03 有 英語 公開
K. Kugou; T. Fukuda; S. Yamada; M. Ito; H. Sasanuma; S. Mori; Y. Katou; T. Itoh; K. Matsumoto; T. Shibata; K. Shirahige; K. Ohta K. Kugou; T. Fukuda; S. Yamada; M. Ito; H. Sasanuma; S. Mori; Y. Katou; T. Itoh; K. Matsumoto; T. Shibata; K. Shirahige; K. Ohta K. Kugou; T. Fukuda; S. Yamada; M. Ito; H. Sasanuma; S. Mori; Y. Katou; T. Itoh; K. Matsumoto; T. Shibata; K. Shirahige; K. Ohta Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes Molecular Biology of the Cell, 20, 13, 3064-3076 Molecular Biology of the Cell, 20, 13, 3064-3076 Molecular Biology of the Cell, 20, 13, 3064-3076 2009 有 英語 公開
H. Sasanuma; K. Hirota; T. Fukuda; N. Kakusho; K. Kugou; Y. Kawasaki; T. Shibata; H. Masai; K. Ohta H. Sasanuma; K. Hirota; T. Fukuda; N. Kakusho; K. Kugou; Y. Kawasaki; T. Shibata; H. Masai; K. Ohta H. Sasanuma; K. Hirota; T. Fukuda; N. Kakusho; K. Kugou; Y. Kawasaki; T. Shibata; H. Masai; K. Ohta Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination Genes and Development, 22, 3, 398-410 Genes and Development, 22, 3, 398-410 Genes and Development, 22, 3, 398-410 2008/02 有 英語 公開
T. Fukuda; K. Kugou; H. Sasanuma; T. Shibata; K. Ohta T. Fukuda; K. Kugou; H. Sasanuma; T. Shibata; K. Ohta T. Fukuda; K. Kugou; H. Sasanuma; T. Shibata; K. Ohta Targeted induction of meiotic double-strand breaks reveals chromosomal domain-dependent regulation of Spo11 and interactions among potential sites of meiotic recombination Targeted induction of meiotic double-strand breaks reveals chromosomal domain-dependent regulation of Spo11 and interactions among potential sites of meiotic recombination Targeted induction of meiotic double-strand breaks reveals chromosomal domain-dependent regulation of Spo11 and interactions among potential sites of meiotic recombination Nucleic Acids Research, 36, 3, 984-997 Nucleic Acids Research, 36, 3, 984-997 Nucleic Acids Research, 36, 3, 984-997 2008/02 有 英語 公開
K. Kugou; H. Sasanuma; K. Matsumoto; K. Shirahige; K. Ohta K. Kugou; H. Sasanuma; K. Matsumoto; K. Shirahige; K. Ohta K. Kugou; H. Sasanuma; K. Matsumoto; K. Shirahige; K. Ohta Mre11 mediates gene regulation in yeast spore development Mre11 mediates gene regulation in yeast spore development Mre11 mediates gene regulation in yeast spore development Genes and Genetic Systems, 82, 1, 21-33 Genes and Genetic Systems, 82, 1, 21-33 Genes and Genetic Systems, 82, 1, 21-33 2007/02 有 英語 公開
H. Sasanuma; H. Murakami; T. Fukuda; T. Shibata; A. Nicolas; K. Ohta H. Sasanuma; H. Murakami; T. Fukuda; T. Shibata; A. Nicolas; K. Ohta H. Sasanuma; H. Murakami; T. Fukuda; T. Shibata; A. Nicolas; K. Ohta Meiotic association between Spo11 regulated by Rec102, Rec104 and Rec114 Meiotic association between Spo11 regulated by Rec102, Rec104 and Rec114 Meiotic association between Spo11 regulated by Rec102, Rec104 and Rec114 Nucleic Acids Research, 35, 4, 1119-1133 Nucleic Acids Research, 35, 4, 1119-1133 Nucleic Acids Research, 35, 4, 1119-1133 2007 有 英語 公開
Y. Araki; Y. Kawasaki; H. Sasanuma; B.K. Tye; A. Sugino Y. Araki; Y. Kawasaki; H. Sasanuma; B.K. Tye; A. Sugino Y. Araki; Y. Kawasaki; H. Sasanuma; B.K. Tye; A. Sugino Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability Genes to Cells, 8, 5, 465-480 Genes to Cells, 8, 5, 465-480 Genes to Cells, 8, 5, 465-480 2003/05 有 英語 公開

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タイトル言語:
外部資金：競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
・科学研究費補助金　若手研究(B) 相同組換えに関与するRad51の新規メディエーター蛋白質Shu複合体の機能解析 〜
若手研究（Ｂ） 代表 遺伝学とプロテオーム解析を組み合わせたDNA損傷応答の新規制御機構の解明 （平成26年度分） 2014/04/01〜2015/03/31
若手研究（Ｂ） 代表 遺伝学とプロテオーム解析を組み合わせたDNA損傷応答の新規制御機構の解明 （平成27年度分） 2015/04/01〜2016/03/31
基盤研究(B) 代表 ホルモン応答性なTopII依存的DNA切断修復異常による病態メカニズムの解明 （平成28年度分） 2016/04/01〜2017/03/31
基盤研究(B) 代表 ホルモン応答性なTopII依存的DNA切断修復異常による病態メカニズムの解明 （平成29年度分） 2017/04/01〜2018/03/31
基盤研究(B) 代表 ホルモン応答性なTopII依存的DNA切断修復異常による病態メカニズムの解明 （平成30年度分） 2018/04/01〜2019/03/31
新学術領域研究（研究領域提案型） 代表 BRCA関連遺伝子の変異による乳がんの発がん機構の解明 （平成30年度分） 2018/04/01〜2019/03/31
部局運営（役職等）
役職名 期間
放射線障害防止委員会 〜

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