山田 宗茂

最終更新日時: 2019/06/13 11:00:19

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氏名(漢字/フリガナ/アルファベット表記)
山田 宗茂/ヤマダ ノリシゲ/Yamada, Norishige
所属部署・職名(部局/所属/講座等/職名)
医学部附属病院/クリニカルバイオリソースセンター/特定助教
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士(医科学) 鹿児島大学
博士(医学) 鹿児島大学
ORCID ID
https://orcid.org/https://orcid.org/0000-0001-5003-5218
researchmap URL
https://researchmap.jp/noriyama
研究テーマ
(日本語)
自己免疫疾患の免疫グロブリン再構成におけるエピジェネティクス機構の解明
研究概要
(日本語)
現在、自己免疫疾患のひとつである全身性エリテマトーデス(SLE)のモデルマウス等の動物試料を用いて、抗体産生に関わる免疫グロブリン遺伝子再構成とその転写に関する研究を行なっている。 SLEモデルマウス等を用いて明らかとなった現象について、ヒトSLE等自己免疫臨床検体を用いて検討することにより、SLEをはじめとする自己免疫疾患の診断応用への可能性を探る。
(英語)
Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that can affect almost any part of the body, and B cell play critical roles in pathogenesis of SLE through autoantibody production. In a mouse model of SLE, aberrant gene rearrangement and transcription were found in immature B cells. These findings open the possibility of using immunoglobulin rearrangement status as diagnostic tool for SLE.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
全身性エリテマトーデス(SLE) Systemic lupus erythematosus
免疫グロブリン遺伝子再構成 Immunoglobulin gene rearrangements
エピジェネティクス Epigenetics
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Miyagawa A, Yoshifuji H, Kitagori K; Ito S, Oku T, Hirayama Y, Salah A, Nakajima T, Kiso K Miyagawa A, Yoshifuji H, Kitagori K; Ito S, Oku T, Hirayama Y, Salah A, Nakajima T, Kiso K Miyagawa A, Yoshifuji H, Kitagori K; Ito S, Oku T, Hirayama Y, Salah A, Nakajima T, Kiso K Increase of MZB1 in B cells in systemic lupus erythematosus: Proteomic analysis of biopsied lymph nodes. Increase of MZB1 in B cells in systemic lupus erythematosus: Proteomic analysis of biopsied lymph nodes. Increase of MZB1 in B cells in systemic lupus erythematosus: Proteomic analysis of biopsied lymph nodes. Arthritis Res Ther,, 20, 1, 13 Arthritis Res Ther,, 20, 1, 13 Arthritis Res Ther,, 20, 1, 13 2018 英語 研究論文(学術雑誌) 公開
Salah A, Yoshifuji H, Ito S, Kitagori K, Kiso K, Yamada N, Nakajima T, Haga H, Tsuruyama T and Miyagawa-Hayashino Salah A, Yoshifuji H, Ito S, Kitagori K, Kiso K, Yamada N, Nakajima T, Haga H, Tsuruyama T and Miyagawa-Hayashino Salah A, Yoshifuji H, Ito S, Kitagori K, Kiso K, Yamada N, Nakajima T, Haga H, Tsuruyama T and Miyagawa-Hayashino High expression of galectin-3 in patients with IgG4-related disease- a proteomic approach. High expression of galectin-3 in patients with IgG4-related disease- a proteomic approach. High expression of galectin-3 in patients with IgG4-related disease- a proteomic approach. Pathol Res Int, 2017, 9312142 Pathol Res Int, 2017, 9312142 Pathol Res Int, 2017, 9312142 2017 英語 研究論文(学術雑誌) 公開
Tsuruyama T, Hiratsuka T and Yamada N Tsuruyama T, Hiratsuka T and Yamada N Tsuruyama T, Hiratsuka T and Yamada N Hotspots of MLV integration in the hematopoietic tumor genome. Hotspots of MLV integration in the hematopoietic tumor genome. Hotspots of MLV integration in the hematopoietic tumor genome. Oncogene, 36, 9, 1169-1175 Oncogene, 36, 9, 1169-1175 Oncogene, 36, 9, 1169-1175 2017 英語 研究論文(学術雑誌) 公開
Yue M, Ogawa A, Yamada N, Lalith CRJ, Ogawa Y Yue M, Ogawa A, Yamada N, Lalith CRJ, Ogawa Y Yue M, Ogawa A, Yamada N, Lalith CRJ, Ogawa Y Xist RNA repeat E is essential for ASH2L recruitment to the inactive X and regulates histone modifications and escape gene expression. Xist RNA repeat E is essential for ASH2L recruitment to the inactive X and regulates histone modifications and escape gene expression. Xist RNA repeat E is essential for ASH2L recruitment to the inactive X and regulates histone modifications and escape gene expression. PLoS Genet, 13, 7, e1006890 PLoS Genet, 13, 7, e1006890 PLoS Genet, 13, 7, e1006890 2017 英語 研究論文(学術雑誌) 公開
Yamada N, Hasegawa Y, Yue M, Hamada T, Nakagawa S and Ogawa Y Yamada N, Hasegawa Y, Yue M, Hamada T, Nakagawa S and Ogawa Y Yamada N, Hasegawa Y, Yue M, Hamada T, Nakagawa S and Ogawa Y Xist Exon 7 Contributes to the Stable Localization of Xist RNA on the Inactive X-Chromosome. Xist Exon 7 Contributes to the Stable Localization of Xist RNA on the Inactive X-Chromosome. Xist Exon 7 Contributes to the Stable Localization of Xist RNA on the Inactive X-Chromosome. PLoS Genet, 11, 8, e100543 PLoS Genet, 11, 8, e100543 PLoS Genet, 11, 8, e100543 2015 英語 研究論文(学術雑誌) 公開
Yamada N and Ogawa Y Yamada N and Ogawa Y Yamada N and Ogawa Y Mechanisms of Long Noncoding Xist RNA-Mediated Chromosome-Wide Gene Silencing in X-Chromosome Inactivation. Mechanisms of Long Noncoding Xist RNA-Mediated Chromosome-Wide Gene Silencing in X-Chromosome Inactivation. Mechanisms of Long Noncoding Xist RNA-Mediated Chromosome-Wide Gene Silencing in X-Chromosome Inactivation. Long Noncoding RNAs: Structures and Functions,, 9, 151-168 , 9, 151-168 Long Noncoding RNAs: Structures and Functions,, 9, 151-168 2015 英語 研究論文(学術雑誌) 公開
Yue M, Lalith CRJ, Yamada N, Ogawa A and Ogawa Y Yue M, Lalith CRJ, Yamada N, Ogawa A and Ogawa Y Yue M, Lalith CRJ, Yamada N, Ogawa A and Ogawa Y Simple and quick fluorescent in situ hybridization protocol for Xist RNA combined with immunofluorescence of histone modification in X-Chromosome inactivation. Simple and quick fluorescent in situ hybridization protocol for Xist RNA combined with immunofluorescence of histone modification in X-Chromosome inactivation. Simple and quick fluorescent in situ hybridization protocol for Xist RNA combined with immunofluorescence of histone modification in X-Chromosome inactivation. JoVE Protocols, 93, e52053 JoVE Protocols, 93, e52053 JoVE Protocols, 93, e52053 2014 英語 研究論文(学術雑誌) 公開
Kamikawa Y, Kanmura Y, Hamada T, Yamada N, Macha M, Batra SK, Higasshi M Yonezawa S and Sugihara K Kamikawa Y, Kanmura Y, Hamada T, Yamada N, Macha M, Batra SK, Higasshi M Yonezawa S and Sugihara K Kamikawa Y, Kanmura Y, Hamada T, Yamada N, Macha M, Batra SK, Higasshi M Yonezawa S and Sugihara K Combination of MUC1 and MUC4 expression predicts clinical outcome in patients with oral squamous cell carcinoma. Combination of MUC1 and MUC4 expression predicts clinical outcome in patients with oral squamous cell carcinoma. Combination of MUC1 and MUC4 expression predicts clinical outcome in patients with oral squamous cell carcinoma. Int J Clin Oncol, 2, 298-307 Int J Clin Oncol, 2, 298-307 Int J Clin Oncol, 2, 298-307 2014 英語 研究論文(学術雑誌) 公開
Kitamoto S, Yokoyama S, Higashi M, Yamada N, Takao S and Yonezawa S Kitamoto S, Yokoyama S, Higashi M, Yamada N, Takao S and Yonezawa S Kitamoto S, Yokoyama S, Higashi M, Yamada N, Takao S and Yonezawa S MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors. MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors. MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors. Oncogene, 32, 4614-4621 Oncogene, 32, 4614-4621 Oncogene, 32, 4614-4621 2013 英語 研究論文(学術雑誌) 公開
Sato A, Yamada N, Ogawa Y and Ikegami M Sato A, Yamada N, Ogawa Y and Ikegami M Sato A, Yamada N, Ogawa Y and Ikegami M CCAAT/Enhancer-Binding Protein-α Suppresses Lung Tumor Development in Mice through the p38α MAP Kinase Pathway. CCAAT/Enhancer-Binding Protein-α Suppresses Lung Tumor Development in Mice through the p38α MAP Kinase Pathway. CCAAT/Enhancer-Binding Protein-α Suppresses Lung Tumor Development in Mice through the p38α MAP Kinase Pathway. PLoS ONE, 8, 2, e57013 PLoS ONE, 8, 2, e57013 PLoS ONE, 8, 2, e57013 2013 英語 研究論文(学術雑誌) 公開
Kitamoto S, Yokoyama S, Higashi M, Yamada N, Matsubara S, Takao S, Batra SK and Yonezawa S Kitamoto S, Yokoyama S, Higashi M, Yamada N, Matsubara S, Takao S, Batra SK and Yonezawa S Kitamoto S, Yokoyama S, Higashi M, Yamada N, Matsubara S, Takao S, Batra SK and Yonezawa S Expression of MUC17 is regulated by HIF1α-mediated hypoxic responses and requires a methylation-free hypoxia responsible element in pancreatic cancer. Expression of MUC17 is regulated by HIF1α-mediated hypoxic responses and requires a methylation-free hypoxia responsible element in pancreatic cancer. Expression of MUC17 is regulated by HIF1α-mediated hypoxic responses and requires a methylation-free hypoxia responsible element in pancreatic cancer. PLoS ONE, 7, 9, e44108 PLoS ONE, 7, 9, e44108 PLoS ONE, 7, 9, e44108 2012 英語 研究論文(学術雑誌) 公開
Yokoyama S, Kitamoto S, Yamada N, Houjou I, Sugai T, Nakamura S, Arisaka Y, Takaori K, Higashi M, Yonezawa S Yokoyama S, Kitamoto S, Yamada N, Houjou I, Sugai T, Nakamura S, Arisaka Y, Takaori K, Higashi M, Yonezawa S Yokoyama S, Kitamoto S, Yamada N, Houjou I, Sugai T, Nakamura S, Arisaka Y, Takaori K, Higashi M, Yonezawa S The application of Methylation specific electrophoresis (MSE) to DNA methylation analysis of the 5’ CpG island of mucin in cancer cells. The application of Methylation specific electrophoresis (MSE) to DNA methylation analysis of the 5’ CpG island of mucin in cancer cells. The application of Methylation specific electrophoresis (MSE) to DNA methylation analysis of the 5’ CpG island of mucin in cancer cells. BMC Cancer, 12, 67 BMC Cancer, 12, 67 BMC Cancer, 12, 67 2012 英語 研究論文(学術雑誌) 公開
Hamada T, Nomura M, Kamikawa Y, Yamada N, Batra SK, Yonezawa S, Sugihara K Hamada T, Nomura M, Kamikawa Y, Yamada N, Batra SK, Yonezawa S, Sugihara K Hamada T, Nomura M, Kamikawa Y, Yamada N, Batra SK, Yonezawa S, Sugihara K DF3 epitope expression on MUC1 Mucin is Associated with Tumor Aggressiveness, Subsequent Lymph Node Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma. DF3 epitope expression on MUC1 Mucin is Associated with Tumor Aggressiveness, Subsequent Lymph Node Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma. DF3 epitope expression on MUC1 Mucin is Associated with Tumor Aggressiveness, Subsequent Lymph Node Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma. Cancer, 118, 21, 5251-5264 Cancer, 118, 21, 5251-5264 Cancer, 118, 21, 5251-5264 2012 英語 研究論文(学術雑誌) 公開
Nagata S, Hamada T, Yamada N, Yokoyama S, Kitamoto S, Kanmura Y, Nomura M, Kamikawa Y, Yonezawa S Nagata S, Hamada T, Yamada N, Yokoyama S, Kitamoto S, Kanmura Y, Nomura M, Kamikawa Y, Yonezawa S Nagata S, Hamada T, Yamada N, Yokoyama S, Kitamoto S, Kanmura Y, Nomura M, Kamikawa Y, Yonezawa S Aberrant DNA methylation of Tumor-related genes in oral rinse: A noninvasive method for detection of oral squamous cell carcinoma. Aberrant DNA methylation of Tumor-related genes in oral rinse: A noninvasive method for detection of oral squamous cell carcinoma. Aberrant DNA methylation of Tumor-related genes in oral rinse: A noninvasive method for detection of oral squamous cell carcinoma. Cancer, 118, 17, 4298-4308 Cancer, 118, 17, 4298-4308 Cancer, 118, 17, 4298-4308 2012 英語 研究論文(学術雑誌) 公開
Higashi M, Yamada N, Yokoyama S, Kitamoto S, Tabata K, Koriyama C, Batra SK and Yonezawa S Higashi M, Yamada N, Yokoyama S, Kitamoto S, Tabata K, Koriyama C, Batra SK and Yonezawa S Higashi M, Yamada N, Yokoyama S, Kitamoto S, Tabata K, Koriyama C, Batra SK and Yonezawa S Pathobiological implications of expression of MUC16/CA125 in intrahepatic cholangiocarcinoma-mass forming type. Pathobiological implications of expression of MUC16/CA125 in intrahepatic cholangiocarcinoma-mass forming type. Pathobiological implications of expression of MUC16/CA125 in intrahepatic cholangiocarcinoma-mass forming type. Pathobiology, 79, 2, 101-106 Pathobiology, 79, 2, 101-106 Pathobiology, 79, 2, 101-106 2012 英語 研究論文(学術雑誌) 公開
Yonezawa S, Kitajima S, Higashi M, Osako M, Horinouchi M, Yokoyama S, Kitamoto S, Yamada N, Tamura Y, Shimizu T, Tabata M and Goto M Yonezawa S, Kitajima S, Higashi M, Osako M, Horinouchi M, Yokoyama S, Kitamoto S, Yamada N, Tamura Y, Shimizu T, Tabata M and Goto M Yonezawa S, Kitajima S, Higashi M, Osako M, Horinouchi M, Yokoyama S, Kitamoto S, Yamada N, Tamura Y, Shimizu T, Tabata M and Goto M A novel anti-MUC1 antibody against the MUC1 cytoplasmic tail domain: use in sensitive identification of poorly differentiated cells in adenocarcinoma of the stomach. A novel anti-MUC1 antibody against the MUC1 cytoplasmic tail domain: use in sensitive identification of poorly differentiated cells in adenocarcinoma of the stomach. A novel anti-MUC1 antibody against the MUC1 cytoplasmic tail domain: use in sensitive identification of poorly differentiated cells in adenocarcinoma of the stomach. Gastric Cancer, 15, 4, 370-381 Gastric Cancer, 15, 4, 370-381 Gastric Cancer, 15, 4, 370-381 2012 英語 研究論文(学術雑誌) 公開
Kusumoto T, Hamada T, Yamada N, Nagata S, Kanmura Y, Houjou I, Kamikawa Y, Yonezawa S, Sugihara K Kusumoto T, Hamada T, Yamada N, Nagata S, Kanmura Y, Houjou I, Kamikawa Y, Yonezawa S, Sugihara K Kusumoto T, Hamada T, Yamada N, Nagata S, Kanmura Y, Houjou I, Kamikawa Y, Yonezawa S, Sugihara K Comprehensive epigenetic analysis using oral rinse samples: a pilot study. Comprehensive epigenetic analysis using oral rinse samples: a pilot study. Comprehensive epigenetic analysis using oral rinse samples: a pilot study. J Oral Maxillofac Surg, 70, 6, 1486-1494 J Oral Maxillofac Surg, 70, 6, 1486-1494 J Oral Maxillofac Surg, 70, 6, 1486-1494 2012 英語 研究論文(学術雑誌) 公開
Hamada T, Wakamatsu T, Miyahara M, Nagata S, Nomura M, Kamikawa Y, Yamada N, Batra SK, Yonezawa S, Sugihara K Hamada T, Wakamatsu T, Miyahara M, Nagata S, Nomura M, Kamikawa Y, Yamada N, Batra SK, Yonezawa S, Sugihara K Hamada T, Wakamatsu T, Miyahara M, Nagata S, Nomura M, Kamikawa Y, Yamada N, Batra SK, Yonezawa S, Sugihara K MUC4 is a novel prognostic factor of oral squamous cell carcinoma. MUC4 is a novel prognostic factor of oral squamous cell carcinoma. MUC4 is a novel prognostic factor of oral squamous cell carcinoma. Int J Cancer, 130, 8, 1768-1776 Int J Cancer, 130, 8, 1768-1776 Int J Cancer, 130, 8, 1768-1776 2012 英語 研究論文(学術雑誌) 公開
Kitamoto S, Yamada N, Yokoyama S, Houjou I, Higashi M, Goto M, Batra SK and Yonezawa S Kitamoto S, Yamada N, Yokoyama S, Houjou I, Higashi M, Goto M, Batra SK and Yonezawa S Kitamoto S, Yamada N, Yokoyama S, Houjou I, Higashi M, Goto M, Batra SK and Yonezawa S DNA methylation and histone H3-K9 modifications contribute to MUC17 expression. DNA methylation and histone H3-K9 modifications contribute to MUC17 expression. DNA methylation and histone H3-K9 modifications contribute to MUC17 expression. Glycobiology, 21, 2, 247-256 Glycobiology, 21, 2, 247-256 Glycobiology, 21, 2, 247-256 2011 英語 研究論文(学術雑誌) 公開
Yonezawa S, Higashi M, Yamada N, Yokoyama S, Kitamoto S, Kitajima S and Goto M Yonezawa S, Higashi M, Yamada N, Yokoyama S, Kitamoto S, Kitajima S and Goto M Yonezawa S, Higashi M, Yamada N, Yokoyama S, Kitamoto S, Kitajima S and Goto M Mucins in human neoplasms: Clinical pathology, gene expression and diagnostic application. Mucins in human neoplasms: Clinical pathology, gene expression and diagnostic application. Mucins in human neoplasms: Clinical pathology, gene expression and diagnostic application. Pathol Int, 61, 12, 697-716 Pathol Int, 61, 12, 697-716 Pathol Int, 61, 12, 697-716 2011 英語 研究論文(学術雑誌) 公開
Yamada N, Kitamoto S, Yokoyama S, Hamada T, Goto M, Tsutsumida H, Higashi M and Yonezawa S Yamada N, Kitamoto S, Yokoyama S, Hamada T, Goto M, Tsutsumida H, Higashi M and Yonezawa S Yamada N, Kitamoto S, Yokoyama S, Hamada T, Goto M, Tsutsumida H, Higashi M and Yonezawa S Epigenetic regulation of mucin genes in human cancers. Epigenetic regulation of mucin genes in human cancers. Epigenetic regulation of mucin genes in human cancers. Clin Epigenetics, 2, 2, 85-96 Clin Epigenetics, 2, 2, 85-96 Clin Epigenetics, 2, 2, 85-96 2011 英語 研究論文(学術雑誌) 公開
Yamada N, Nishida Y, Yokoyama S, Tsutsumida H, Houjou I, Kitamoto S, Goto M, Higashi M and Yonezawa S Yamada N, Nishida Y, Yokoyama S, Tsutsumida H, Houjou I, Kitamoto S, Goto M, Higashi M and Yonezawa S Yamada N, Nishida Y, Yokoyama S, Tsutsumida H, Houjou I, Kitamoto S, Goto M, Higashi M and Yonezawa S Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells. Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells. Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells. J. Hepatobiliary Pancreat Sci, 17, 6, 844-854 J. Hepatobiliary Pancreat Sci, 17, 6, 844-854 J. Hepatobiliary Pancreat Sci, 17, 6, 844-854 2010 英語 研究論文(学術雑誌) 公開
Yonezawa S, Higashi M, Yamada N, Yokoyama S and Goto M Yonezawa S, Higashi M, Yamada N, Yokoyama S and Goto M Yonezawa S, Higashi M, Yamada N, Yokoyama S and Goto M Significance of mucin expression in pancreatobiliary neoplasms. Significance of mucin expression in pancreatobiliary neoplasms. Significance of mucin expression in pancreatobiliary neoplasms. J. Hepatobiliary Pancreat Sci, 17, 2, 108-124 J. Hepatobiliary Pancreat Sci, 17, 2, 108-124 J. Hepatobiliary Pancreat Sci, 17, 2, 108-124 2010 英語 研究論文(学術雑誌) 公開
Yonezawa S, Yamada N, Yokoyama S, Kitamoto S, Higashi M and Goto M Yonezawa S, Yamada N, Yokoyama S, Kitamoto S, Higashi M and Goto M Yonezawa S, Yamada N, Yokoyama S, Kitamoto S, Higashi M and Goto M MUC2 (mucin 2, oligomeric mucus/gel-forming) MUC2 (mucin 2, oligomeric mucus/gel-forming) MUC2 (mucin 2, oligomeric mucus/gel-forming) Atlas of Genetics and Cytogenetics in Oncology and Haematology, 14, 9, 827-833 Atlas of Genetics and Cytogenetics in Oncology and Haematology, 14, 9, 827-833 Atlas of Genetics and Cytogenetics in Oncology and Haematology, 14, 9, 827-833 2009 英語 研究論文(学術雑誌) 公開
Yamada N, Nishida Y, Tsutsumida H, Goto M, Higashi M, Nomoto M and Yonezawa S Yamada N, Nishida Y, Tsutsumida H, Goto M, Higashi M, Nomoto M and Yonezawa S Yamada N, Nishida Y, Tsutsumida H, Goto M, Higashi M, Nomoto M and Yonezawa S Promoter CpG methylation in cancer cells contributes to regulation of MUC4. Promoter CpG methylation in cancer cells contributes to regulation of MUC4. Promoter CpG methylation in cancer cells contributes to regulation of MUC4. Br. J. Cancer, 100, 2, 344-351 Br. J. Cancer, 100, 2, 344-351 Br. J. Cancer, 100, 2, 344-351 2009 英語 研究論文(学術雑誌) 公開
Yonezawa S, Goto M, Yamada N, Higashi M and Nomoto M Yonezawa S, Goto M, Yamada N, Higashi M and Nomoto M Yonezawa S, Goto M, Yamada N, Higashi M and Nomoto M Expression profiles of MUC1, MUC2 and MUC4 mucins in human neoplasms and their relationship with biological behavior. Expression profiles of MUC1, MUC2 and MUC4 mucins in human neoplasms and their relationship with biological behavior. Expression profiles of MUC1, MUC2 and MUC4 mucins in human neoplasms and their relationship with biological behavior. Proteomics, 8, 16, 3329-3341 Proteomics, 8, 16, 3329-3341 Proteomics, 8, 16, 3329-3341 2008 英語 研究論文(学術雑誌) 公開
Yamada N, Nishida Y, Tsutsumida H, Hamada T, Goto M, Higashi M, Nomoto M and Yonezawa S Yamada N, Nishida Y, Tsutsumida H, Hamada T, Goto M, Higashi M, Nomoto M and Yonezawa S Yamada N, Nishida Y, Tsutsumida H, Hamada T, Goto M, Higashi M, Nomoto M and Yonezawa S MUC1 expression is regulated by DNA methylation and histone H3-K9 modification in cancer cells. MUC1 expression is regulated by DNA methylation and histone H3-K9 modification in cancer cells. MUC1 expression is regulated by DNA methylation and histone H3-K9 modification in cancer cells. Cancer Res, 68, 8, 2708-2716 Cancer Res, 68, 8, 2708-2716 Cancer Res, 68, 8, 2708-2716 2008 英語 研究論文(学術雑誌) 公開
Yonezawa S, Higashi M, Yamada N, and Goto M Yonezawa S, Higashi M, Yamada N, and Goto M Yonezawa S, Higashi M, Yamada N, and Goto M Precursor Lesions of Pancreatic Cancer. Precursor Lesions of Pancreatic Cancer. Precursor Lesions of Pancreatic Cancer. Gut and Liver, 2, 3, 137-154 Gut and Liver, 2, 3, 137-154 Gut and Liver, 2, 3, 137-154 2008 英語 研究論文(学術雑誌) 公開
Yamada N, Hamada T, Goto M, Tsutsumida H, Higashi M, Nomoto M and Yonezawa S Yamada N, Hamada T, Goto M, Tsutsumida H, Higashi M, Nomoto M and Yonezawa S Yamada N, Hamada T, Goto M, Tsutsumida H, Higashi M, Nomoto M and Yonezawa S MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. Int. J. Cancer, 119, 8, 1850-1857 Int. J. Cancer, 119, 8, 1850-1857 Int. J. Cancer, 119, 8, 1850-1857 2006 英語 研究論文(学術雑誌) 公開
Goto M, Nakanaga K, Aung T, Hamada T, Yamada N, Nomoto M, Kitajima S, Ishii N, Yonezawa S and Saito H Goto M, Nakanaga K, Aung T, Hamada T, Yamada N, Nomoto M, Kitajima S, Ishii N, Yonezawa S and Saito H Goto M, Nakanaga K, Aung T, Hamada T, Yamada N, Nomoto M, Kitajima S, Ishii N, Yonezawa S and Saito H Nerve damage in mycobacterium ulcerans-infected mice. Probable cause of painlessness in buruli ulcer. Nerve damage in mycobacterium ulcerans-infected mice. Probable cause of painlessness in buruli ulcer. Nerve damage in mycobacterium ulcerans-infected mice. Probable cause of painlessness in buruli ulcer. Am. J. Pathol, 168, 3, 805-811 Am. J. Pathol, 168, 3, 805-811 Am. J. Pathol, 168, 3, 805-811 2006 英語 研究論文(学術雑誌) 公開
Yamada N and Yonezawa S Yamada N and Yonezawa S Understanding Epigenetic Status: DNA Methylation and Cancer. Understanding Epigenetic Status: DNA Methylation and Cancer. J Cancer Biol Res, 1, 2, 1008 , 1, 2, 1008 J Cancer Biol Res, 1, 2, 1008 2013 英語 研究論文(学術雑誌) 公開

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著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
米澤傑、横山勢也、山田宗茂、北本祥、東美智代 米澤傑、横山勢也、山田宗茂、北本祥、東美智代 特集「COPDを改めて問う」エピジェネティクスによるムチン発現制御. 特集「COPDを改めて問う」エピジェネティクスによるムチン発現制御. THE LUNG perspectives, 22, 2, 185-190 THE LUNG perspectives, 22, 2, 185-190 , 22, 2, 185-190 2014 日本語 総説・解説(学術雑誌) 公開
山田宗茂、合山進、上野将紀、佐々木敦朗 山田宗茂、合山進、上野将紀、佐々木敦朗 研コミュ白書 第9回 UC-Tomorrow: シンシナティから発する明日のサイエンスへの光­―遥かなる上を目指して― 研コミュ白書 第9回 UC-Tomorrow: シンシナティから発する明日のサイエンスへの光­―遥かなる上を目指して― 細胞工学、学研メディカル秀潤社, 32, 11, 1174-1177 細胞工学、学研メディカル秀潤社, 32, 11, 1174-1177 , 32, 11, 1174-1177 2013 日本語 その他記事 公開
米澤傑、東美智代、横山勢也、北本祥、山田宗茂 米澤傑、東美智代、横山勢也、北本祥、山田宗茂 癌におけるムチンの臨床病理学的意義および診断への応用 −難治性膵胆管癌の早期診断に向けて− 癌におけるムチンの臨床病理学的意義および診断への応用 −難治性膵胆管癌の早期診断に向けて− MEDICAL TECNOLOGY, 40, 4, 419-425 MEDICAL TECNOLOGY, 40, 4, 419-425 , 40, 4, 419-425 2012 日本語 総説・解説(学術雑誌) 公開
米澤傑、山田宗茂、横山勢也、北本祥、田畑和宏、東美智代 米澤傑、山田宗茂、横山勢也、北本祥、田畑和宏、東美智代 「第2部:病理診断医になじみのある疾患関連分子 MUC(腫瘍等)解説編・診断編」 「第2部:病理診断医になじみのある疾患関連分子 MUC(腫瘍等)解説編・診断編」 『病理と臨床(臨時増刊号)』文光堂, 29, 328-340 『病理と臨床(臨時増刊号)』文光堂, 29, 328-340 , 29, 328-340 2011 日本語 総説・解説(学術雑誌) 公開
東美智代、田畑和宏、横山勢也、山田宗茂、米澤傑 東美智代、田畑和宏、横山勢也、山田宗茂、米澤傑 腫瘍発生と化生・粘液形質 腫瘍発生と化生・粘液形質 肝胆膵, 62, 1, 29-38 肝胆膵, 62, 1, 29-38 , 62, 1, 29-38 2011 日本語 総説・解説(学術雑誌) 公開
米澤傑、東美智代、山田宗茂、北本祥、横山勢也、有坂好史、高折恭一 米澤傑、東美智代、山田宗茂、北本祥、横山勢也、有坂好史、高折恭一 「IPMN の組織亜型と分化発育」 「IPMN の組織亜型と分化発育」 肝胆膵、株式会社アークメディア, 61, 3, 343-358 肝胆膵、株式会社アークメディア, 61, 3, 343-358 , 61, 3, 343-358 2010 日本語 総説・解説(学術雑誌) 公開
米澤傑、東美智代、山田宗茂、堀之内道子、野元三治、後藤正道 米澤傑、東美智代、山田宗茂、堀之内道子、野元三治、後藤正道 「-上皮性腫瘍の粘液細胞形質診断-免疫染色(1):ムチンの概説と,消化器腫瘍の新しい予後因子としてのMUC1,MUC2,MUC4の発現とその意義について」 「-上皮性腫瘍の粘液細胞形質診断-免疫染色(1):ムチンの概説と,消化器腫瘍の新しい予後因子としてのMUC1,MUC2,MUC4の発現とその意義について」 胃と腸、医学書院, 44, 3, 417-424 胃と腸、医学書院, 44, 3, 417-424 , 44, 3, 417-424 2009 日本語 総説・解説(学術雑誌) 公開
米澤傑、東美智代、山田宗茂、堀之内道子、野元三治、後藤正道 米澤傑、東美智代、山田宗茂、堀之内道子、野元三治、後藤正道 -上皮性腫瘍の粘液細胞形質診断-免疫染色 (2): ムチン発現の遺伝子機構の解明と,胃と大腸の腫瘍における胃型ムチン(MUC5AC,MUC6)と腸型ムチン(MUC2)の発現について」 -上皮性腫瘍の粘液細胞形質診断-免疫染色 (2): ムチン発現の遺伝子機構の解明と,胃と大腸の腫瘍における胃型ムチン(MUC5AC,MUC6)と腸型ムチン(MUC2)の発現について」 胃と腸、医学書院, 44, 5, 916-922 胃と腸、医学書院, 44, 5, 916-922 , 44, 5, 916-922 2009 日本語 総説・解説(学術雑誌) 公開
米澤傑、東美智代、山田宗茂、堀之内道子、野元三治、後藤正道 米澤傑、東美智代、山田宗茂、堀之内道子、野元三治、後藤正道 「IPMNにおけるムチン発現と悪性度-ムチン発現を加味したIPMNの亜分類と国際診療ガイドラインとの関連性」 「IPMNにおけるムチン発現と悪性度-ムチン発現を加味したIPMNの亜分類と国際診療ガイドラインとの関連性」 膵と胆、医学図書出版株式会社, 30, 3, 221-231 膵と胆、医学図書出版株式会社, 30, 3, 221-231 , 30, 3, 221-231 2009 日本語 総説・解説(学術雑誌) 公開
米澤傑、山田宗茂、東美智代 米澤傑、山田宗茂、東美智代 糖蛋白異常の分子病理診断への展開 (第1土曜特集 がん分子病理診断の新展開) -- (分子診断の実践と展開)」 糖蛋白異常の分子病理診断への展開 (第1土曜特集 がん分子病理診断の新展開) -- (分子診断の実践と展開)」 医学のあゆみ、医歯薬出版, 229, 10, 987-993 医学のあゆみ、医歯薬出版, 229, 10, 987-993 , 229, 10, 987-993 2009 日本語 総説・解説(学術雑誌) 公開
タイトル言語:
外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
日本学術振興会 特別研究員奨励費 代表 エピジェネティクスによるムチン抗原遺伝子発現機構の解明 2009/04/01〜2011/03/31
日本学術振興会 海外特別研究員 代表 不活性化X染色体におけるEscape genes発現制御機構の解明 2013/04/01〜2015/03/31
日本学術振興会科研費 若手研究(B) 代表 自己免疫疾患の免疫グロブリン再構成におけるエピジェネティクス機構の解明 2016/04/01〜2018/03/31
日本学術振興会科研費 基盤研究(C)(一般) 代表 免疫グロブリン遺伝子再構成・転写異常によるSLE発症機構の解明 2018/04/01〜2021/03/31