萩原 正敏

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氏名(漢字/フリガナ/アルファベット表記)
萩原 正敏/ハギワラ マサトシ/Hagiwara, Masatoshi
所属部署・職名(部局/所属/講座等/職名)
医学研究科/医学専攻生体構造医学講座形態形成機構学/教授
学部兼担
部局 所属 講座等 職名
医学部
連絡先住所
種別 住所(日本語) 住所(英語)
職場 京都市左京区吉田近衛町 Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
連絡先電話番号
種別 番号
職場 075-753-4341
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
医学博士 三重大学
職歴
期間 組織名(日本語) 組織名(英語) 職名(日本語) 職名(英語)
researchmap URL
https://researchmap.jp/read0011076
研究テーマ
(日本語)
mRNAスプライシング制御機構の解明、RNA病治療薬の開発、抗ウィルス薬の開発研究
(英語)
RNA Splicing, Genetic Diseases, Drug Discovery
研究概要
(日本語)
患者の染色体や遺伝子の異常に起因する先天性疾患に対して、遺伝子治療やiPS細胞などに期待が寄せられている。ところが、当然ながら、患者の細胞や遺伝子を人為的に置き換えることは、神ならぬ我々には非常に困難である。これまで医学・薬学が発展させてきた創薬技術を基に、低分子の化合物を新しいアイデアで用いることにより、先天性難治疾患に対する治療薬開発を試みる方が、むしろ現実的なのではないだろうか?何故なら、染色体や遺伝子に異常があっても、そこから発現するRNAに影響を与える化合物を見つけ、症状の発現を抑えることは論理的に可能であるからだ。このような発想から、全く新しい創薬スクリーニング方法を考案し、ダウン症児の白血病、デュシェンネ型筋ジストロフィー、薬剤耐性ヘルペス感染症、遺伝性自律神経失調症、アルツハイマー病、神経障害性疼痛、加齢性黄斑変性等々、従来の薬剤では治療が困難であった疾患に対する治療薬候補物質を、我々の研究室では続々と見つけつつある。
(英語)
He succeeded to visualize tissue-specific and developmental-stage-specific alternative splicing patterns in living nematode worms, and identified the regulatory factors by genomic mapping of the mutants (Nat Methods 2006, Nat Protocols 2010). He further developed the splicing reporter technology, established a dual-color splicing reporter screening system called SPREADD (splicing reporter assay for disease genes with dual-color), applied this to aberrant splicing of IKBKAP exon 20 found in FD patients due to the intronic mutation (IVS20+6T>C), and identified a compound RECTAS that efficiently corrects the mis-splicing of IKBKAP (PNAS 2015). He also developed an anti-virus drug FIT039 targeting host factors required for virus proliferation. FIT039 specifically inhibits CDK9 and suppresses viral transcription of a broad spectrum of DNA viruses including HCMV, HAdV, HBV and HPV without significant adverse effect on mammalian cells (J Clin Invest. 2014, Clin Cancer Res. 2018). The phase1/2a clinical trial of FIT039 for cervical intraepithelial neoplasia (CIN) is under the way in Kyoto University Hospital.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
ケミカルバイオロジー Chemical Biology
RNA RNA Biology
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Ichisima J, Suzuki NM, Samata B, Awaya T, Takahashi J, Hagiwara M, Nakahata T, Saito MK Ichisima J, Suzuki NM, Samata B, Awaya T, Takahashi J, Hagiwara M, Nakahata T, Saito MK Ichisima J, Suzuki NM, Samata B, Awaya T, Takahashi J, Hagiwara M, Nakahata T, Saito MK Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model. Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model. Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model. Journal of human genetics, 64, 5, 445-458 Journal of human genetics, 64, 5, 445-458 Journal of human genetics, 64, 5, 445-458 2019/05 公開
Kimura R, Swarup V, Tomiwa K, Gandal MJ, Parikshak NN, Funabiki Y, Nakata M, Awaya T, Kato T, Iida K, Okazaki S, Matsushima K, Kato T, Murai T, Heike T, Geschwind DH, Hagiwara M Kimura R, Swarup V, Tomiwa K, Gandal MJ, Parikshak NN, Funabiki Y, Nakata M, Awaya T, Kato T, Iida K, Okazaki S, Matsushima K, Kato T, Murai T, Heike T, Geschwind DH, Hagiwara M Kimura R, Swarup V, Tomiwa K, Gandal MJ, Parikshak NN, Funabiki Y, Nakata M, Awaya T, Kato T, Iida K, Okazaki S, Matsushima K, Kato T, Murai T, Heike T, Geschwind DH, Hagiwara M Integrative network analysis reveals biological pathways associated with Williams syndrome. Integrative network analysis reveals biological pathways associated with Williams syndrome. Integrative network analysis reveals biological pathways associated with Williams syndrome. Journal of child psychology and psychiatry, and allied disciplines, 60, 5, 585-598 Journal of child psychology and psychiatry, and allied disciplines, 60, 5, 585-598 Journal of child psychology and psychiatry, and allied disciplines, 60, 5, 585-598 2019/05 公開
Hosokawa M, Takeuchi A, Tanihata J, Iida K, Takeda S, Hagiwara M Hosokawa M, Takeuchi A, Tanihata J, Iida K, Takeda S, Hagiwara M Hosokawa M, Takeuchi A, Tanihata J, Iida K, Takeda S, Hagiwara M Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy. Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy. Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy. iScience, 13, 229-242 iScience, 13, 229-242 iScience, 13, 229-242 2019/03 公開
Korogi Y, Gotoh S, Ikeo S, Yamamoto Y, Sone N, Tamai K, Konishi S, Nagasaki T, Matsumoto H, Ito I, Chen-Yoshikawa TF, Date H, Hagiwara M, Asaka I, Hotta A, Mishima M, Hirai T Korogi Y, Gotoh S, Ikeo S, Yamamoto Y, Sone N, Tamai K, Konishi S, Nagasaki T, Matsumoto H, Ito I, Chen-Yoshikawa TF, Date H, Hagiwara M, Asaka I, Hotta A, Mishima M, Hirai T Korogi Y, Gotoh S, Ikeo S, Yamamoto Y, Sone N, Tamai K, Konishi S, Nagasaki T, Matsumoto H, Ito I, Chen-Yoshikawa TF, Date H, Hagiwara M, Asaka I, Hotta A, Mishima M, Hirai T In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids. In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids. In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids. Stem cell reports, 12, 3, 431-440 Stem cell reports, 12, 3, 431-440 Stem cell reports, 12, 3, 431-440 2019/03 公開
Boisson B, Honda Y, Ajiro M, Bustamante J, Bendavid M, Gennery AR, Kawasaki Y, Ichishima J, Osawa M, Nihira H, Shiba T, Tanaka T, Chrabieh M, Bigio B, Hur H, Itan Y, Liang Y, Okada S, Izawa K, Nishikomori R, Ohara O, Heike T, Abel L, Puel A, Saito MK, Casanova JL, Hagiwara M, Yasumi T Boisson B, Honda Y, Ajiro M, Bustamante J, Bendavid M, Gennery AR, Kawasaki Y, Ichishima J, Osawa M, Nihira H, Shiba T, Tanaka T, Chrabieh M, Bigio B, Hur H, Itan Y, Liang Y, Okada S, Izawa K, Nishikomori R, Ohara O, Heike T, Abel L, Puel A, Saito MK, Casanova JL, Hagiwara M, Yasumi T Boisson B, Honda Y, Ajiro M, Bustamante J, Bendavid M, Gennery AR, Kawasaki Y, Ichishima J, Osawa M, Nihira H, Shiba T, Tanaka T, Chrabieh M, Bigio B, Hur H, Itan Y, Liang Y, Okada S, Izawa K, Nishikomori R, Ohara O, Heike T, Abel L, Puel A, Saito MK, Casanova JL, Hagiwara M, Yasumi T Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency. Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency. Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency. The Journal of clinical investigation, 129, 2, 583-597 The Journal of clinical investigation, 129, 2, 583-597 The Journal of clinical investigation, 129, 2, 583-597 2019/02 公開
Sumi E, Nomura T, Asada R, Uozumi R, Tada H, Amino Y, Sawada T, Yonezawa A, Hagiwara M, Kabashima K Sumi E, Nomura T, Asada R, Uozumi R, Tada H, Amino Y, Sawada T, Yonezawa A, Hagiwara M, Kabashima K Sumi E, Nomura T, Asada R, Uozumi R, Tada H, Amino Y, Sawada T, Yonezawa A, Hagiwara M, Kabashima K Safety and Plasma Concentrations of a Cyclin-dependent Kinase 9 (CDK9) Inhibitor, FIT039, Administered by a Single Adhesive Skin Patch Applied on Normal Skin and Cutaneous Warts. Safety and Plasma Concentrations of a Cyclin-dependent Kinase 9 (CDK9) Inhibitor, FIT039, Administered by a Single Adhesive Skin Patch Applied on Normal Skin and Cutaneous Warts. Safety and Plasma Concentrations of a Cyclin-dependent Kinase 9 (CDK9) Inhibitor, FIT039, Administered by a Single Adhesive Skin Patch Applied on Normal Skin and Cutaneous Warts. Clinical drug investigation, 39, 1, 55-61 Clinical drug investigation, 39, 1, 55-61 Clinical drug investigation, 39, 1, 55-61 2018/10 公開
Arbones ML, Thomazeau A, Nakano-Kobayashi A, Hagiwara M, Delabar JM Arbones ML, Thomazeau A, Nakano-Kobayashi A, Hagiwara M, Delabar JM Arbones ML, Thomazeau A, Nakano-Kobayashi A, Hagiwara M, Delabar JM DYRK1A and cognition: A lifelong relationship. DYRK1A and cognition: A lifelong relationship. DYRK1A and cognition: A lifelong relationship. Pharmacology & therapeutics Pharmacology & therapeutics Pharmacology & therapeutics 2018/09 公開
Fuji H, Ohmae S, Noma N, Takeiri M, Yasutomi H, Izumi K, Ito M, Toyomoto M, Iwaki S, Takemoto K, Seo S, Taura K, Hida S, Aoyama M, Ishihama Y, Hagiwara M, Takeda N, Hatano E, Iwaisako K, Uemoto S, Asagiri M Fuji H, Ohmae S, Noma N, Takeiri M, Yasutomi H, Izumi K, Ito M, Toyomoto M, Iwaki S, Takemoto K, Seo S, Taura K, Hida S, Aoyama M, Ishihama Y, Hagiwara M, Takeda N, Hatano E, Iwaisako K, Uemoto S, Asagiri M Fuji H, Ohmae S, Noma N, Takeiri M, Yasutomi H, Izumi K, Ito M, Toyomoto M, Iwaki S, Takemoto K, Seo S, Taura K, Hida S, Aoyama M, Ishihama Y, Hagiwara M, Takeda N, Hatano E, Iwaisako K, Uemoto S, Asagiri M Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation. Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation. Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation. Biochemical and biophysical research communications, 503, 2, 544-549 Biochemical and biophysical research communications, 503, 2, 544-549 Biochemical and biophysical research communications, 503, 2, 544-549 2018/09 公開
Ajiro M, Sakai H, Onogi H, Yamamoto M, Sumi E, Sawada T, Nomura T, Kabashima K, Hosoya T, Hagiwara M Ajiro M, Sakai H, Onogi H, Yamamoto M, Sumi E, Sawada T, Nomura T, Kabashima K, Hosoya T, Hagiwara M Ajiro M, Sakai H, Onogi H, Yamamoto M, Sumi E, Sawada T, Nomura T, Kabashima K, Hosoya T, Hagiwara M CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia. CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia. CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia. Clinical cancer research : an official journal of the American Association for Cancer Research, 24, 18, 4518-4528 Clinical cancer research : an official journal of the American Association for Cancer Research, 24, 18, 4518-4528 Clinical cancer research : an official journal of the American Association for Cancer Research, 24, 18, 4518-4528 2018/09 公開
Yamada S, Nagai M, Hagiwara M Yamada S, Nagai M, Hagiwara M Yamada S, Nagai M, Hagiwara M The 40th Anniversary of the Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine. The 40th Anniversary of the Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine. The 40th Anniversary of the Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine. Anatomical record (Hoboken, N.J. : 2007), 301, 6, 947-950 Anatomical record (Hoboken, N.J. : 2007), 301, 6, 947-950 Anatomical record (Hoboken, N.J. : 2007), 301, 6, 947-950 2018/06 公開
Takeuchi A, Iida K, Tsubota T, Hosokawa M, Denawa M, Brown JB, Ninomiya K, Ito M, Kimura H, Abe T, Kiyonari H, Ohno K, Hagiwara M Takeuchi A, Iida K, Tsubota T, Hosokawa M, Denawa M, Brown JB, Ninomiya K, Ito M, Kimura H, Abe T, Kiyonari H, Ohno K, Hagiwara M Takeuchi A, Iida K, Tsubota T, Hosokawa M, Denawa M, Brown JB, Ninomiya K, Ito M, Kimura H, Abe T, Kiyonari H, Ohno K, Hagiwara M Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain. Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain. Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain. Cell reports, 23, 5, 1326-1341 Cell reports, 23, 5, 1326-1341 Cell reports, 23, 5, 1326-1341 2018/05 公開
Yoshida S, Kanno K, Kii I, Misawa Y, Hagiwara M, Hosoya T Yoshida S, Kanno K, Kii I, Misawa Y, Hagiwara M, Hosoya T Yoshida S, Kanno K, Kii I, Misawa Y, Hagiwara M, Hosoya T Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions. Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions. Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions. Chemical communications (Cambridge, England), 54, 30, 3705-3708 Chemical communications (Cambridge, England), 54, 30, 3705-3708 Chemical communications (Cambridge, England), 54, 30, 3705-3708 2018/04 公開
Kimura R, Ishii Y, Tomiwa K, Awaya T, Nakata M, Kato T, Okazaki S, Heike T, Hagiwara M Kimura R, Ishii Y, Tomiwa K, Awaya T, Nakata M, Kato T, Okazaki S, Heike T, Hagiwara M Kimura R, Ishii Y, Tomiwa K, Awaya T, Nakata M, Kato T, Okazaki S, Heike T, Hagiwara M Williams-Beuren Syndrome as a Potential Risk Factor for Burkitt Lymphoma. Williams-Beuren Syndrome as a Potential Risk Factor for Burkitt Lymphoma. Williams-Beuren Syndrome as a Potential Risk Factor for Burkitt Lymphoma. Frontiers in genetics, 9, 368 Frontiers in genetics, 9, 368 Frontiers in genetics, 9, 368 2018 公開
Nakano-Kobayashi A, Awaya T, Kii I, Sumida Y, Okuno Y, Yoshida S, Sumida T, Inoue H, Hosoya T, Hagiwara M Nakano-Kobayashi A, Awaya T, Kii I, Sumida Y, Okuno Y, Yoshida S, Sumida T, Inoue H, Hosoya T, Hagiwara M Nakano-Kobayashi A, Awaya T, Kii I, Sumida Y, Okuno Y, Yoshida S, Sumida T, Inoue H, Hosoya T, Hagiwara M Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice. Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice. Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice. Proceedings of the National Academy of Sciences of the United States of America, 114, 38, 10268-10273 Proceedings of the National Academy of Sciences of the United States of America, 114, 38, 10268-10273 Proceedings of the National Academy of Sciences of the United States of America, 114, 38, 10268-10273 2017/09 公開
Ohe K, Yoshida M, Nakano-Kobayashi A, Hosokawa M, Sako Y, Sakuma M, Okuno Y, Usui T, Ninomiya K, Nojima T, Kataoka N, Hagiwara M Ohe K, Yoshida M, Nakano-Kobayashi A, Hosokawa M, Sako Y, Sakuma M, Okuno Y, Usui T, Ninomiya K, Nojima T, Kataoka N, Hagiwara M Ohe K, Yoshida M, Nakano-Kobayashi A, Hosokawa M, Sako Y, Sakuma M, Okuno Y, Usui T, Ninomiya K, Nojima T, Kataoka N, Hagiwara M RBM24 promotes U1 snRNP recognition of the mutated 5' splice site in the <i>IKBKAP</i> gene of familial dysautonomia. RBM24 promotes U1 snRNP recognition of the mutated 5' splice site in the <i>IKBKAP</i> gene of familial dysautonomia. RBM24 promotes U1 snRNP recognition of the mutated 5' splice site in the <i>IKBKAP</i> gene of familial dysautonomia. RNA (New York, N.Y.), 23, 9, 1393-1403 RNA (New York, N.Y.), 23, 9, 1393-1403 RNA (New York, N.Y.), 23, 9, 1393-1403 2017/09 公開
Kawaguchi K, Suzuki E, Nishie M, Kii I, Kataoka TR, Hirata M, Inoue M, Pu F, Iwaisako K, Tsuda M, Yamaguchi A, Haga H, Hagiwara M, Toi M Kawaguchi K, Suzuki E, Nishie M, Kii I, Kataoka TR, Hirata M, Inoue M, Pu F, Iwaisako K, Tsuda M, Yamaguchi A, Haga H, Hagiwara M, Toi M Kawaguchi K, Suzuki E, Nishie M, Kii I, Kataoka TR, Hirata M, Inoue M, Pu F, Iwaisako K, Tsuda M, Yamaguchi A, Haga H, Hagiwara M, Toi M Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity. Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity. Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity. Cancer immunology, immunotherapy : CII, 66, 9, 1131-1142 Cancer immunology, immunotherapy : CII, 66, 9, 1131-1142 Cancer immunology, immunotherapy : CII, 66, 9, 1131-1142 2017/09 公開
Matsumoto S, Iida K, Murata A, Denawa M, Hagiwara M, Nakatani K Matsumoto S, Iida K, Murata A, Denawa M, Hagiwara M, Nakatani K Matsumoto S, Iida K, Murata A, Denawa M, Hagiwara M, Nakatani K Synthetic ligand promotes gene expression by affecting GC sequence in promoter. Synthetic ligand promotes gene expression by affecting GC sequence in promoter. Synthetic ligand promotes gene expression by affecting GC sequence in promoter. Bioorganic & medicinal chemistry letters, 27, 15, 3391-3394 Bioorganic & medicinal chemistry letters, 27, 15, 3391-3394 Bioorganic & medicinal chemistry letters, 27, 15, 3391-3394 2017/08 公開
Ohta H, Kurimoto K, Okamoto I, Nakamura T, Yabuta Y, Miyauchi H, Yamamoto T, Okuno Y, Hagiwara M, Shirane K, Sasaki H, Saitou M Ohta H, Kurimoto K, Okamoto I, Nakamura T, Yabuta Y, Miyauchi H, Yamamoto T, Okuno Y, Hagiwara M, Shirane K, Sasaki H, Saitou M Ohta H, Kurimoto K, Okamoto I, Nakamura T, Yabuta Y, Miyauchi H, Yamamoto T, Okuno Y, Hagiwara M, Shirane K, Sasaki H, Saitou M <i>In vitro</i> expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate. <i>In vitro</i> expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate. <i>In vitro</i> expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate. The EMBO journal, 36, 13, 1888-1907 The EMBO journal, 36, 13, 1888-1907 The EMBO journal, 36, 13, 1888-1907 2017/07 公開
Nguyen BN, Okuno Y, Ajiro M, Iida K, Denawa M, Yamamoto M, Sakamoto N, Kagechika H, Hagiwara M Nguyen BN, Okuno Y, Ajiro M, Iida K, Denawa M, Yamamoto M, Sakamoto N, Kagechika H, Hagiwara M Nguyen BN, Okuno Y, Ajiro M, Iida K, Denawa M, Yamamoto M, Sakamoto N, Kagechika H, Hagiwara M Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression. Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression. Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression. Journal of medical virology, 89, 7, 1224-1234 Journal of medical virology, 89, 7, 1224-1234 Journal of medical virology, 89, 7, 1224-1234 2017/07 公開
Sako Y, Ninomiya K, Okuno Y, Toyomoto M, Nishida A, Koike Y, Ohe K, Kii I, Yoshida S, Hashimoto N, Hosoya T, Matsuo M, Hagiwara M Sako Y, Ninomiya K, Okuno Y, Toyomoto M, Nishida A, Koike Y, Ohe K, Kii I, Yoshida S, Hashimoto N, Hosoya T, Matsuo M, Hagiwara M Sako Y, Ninomiya K, Okuno Y, Toyomoto M, Nishida A, Koike Y, Ohe K, Kii I, Yoshida S, Hashimoto N, Hosoya T, Matsuo M, Hagiwara M Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy. Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy. Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy. Scientific reports, 7, 46126 Scientific reports, 7, 46126 Scientific reports, 7, 46126 2017/05 公開
Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji H, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji H, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji H, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K. Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K. Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K. Scientific reports, 7, 41710 Scientific reports, 7, 41710 Scientific reports, 7, 41710 2017/03 公開
Wang DO, Ninomiya K, Mori C, Koyama A, Haan M, Kitabatake M, Hagiwara M, Chida K, Takahashi SI, Ohno M, Kataoka N Wang DO, Ninomiya K, Mori C, Koyama A, Haan M, Kitabatake M, Hagiwara M, Chida K, Takahashi SI, Ohno M, Kataoka N Wang DO, Ninomiya K, Mori C, Koyama A, Haan M, Kitabatake M, Hagiwara M, Chida K, Takahashi SI, Ohno M, Kataoka N Transport Granules Bound with Nuclear Cap Binding Protein and Exon Junction Complex Are Associated with Microtubules and Spatially Separated from eIF4E Granules and P Bodies in Human Neuronal Processes. Transport Granules Bound with Nuclear Cap Binding Protein and Exon Junction Complex Are Associated with Microtubules and Spatially Separated from eIF4E Granules and P Bodies in Human Neuronal Processes. Transport Granules Bound with Nuclear Cap Binding Protein and Exon Junction Complex Are Associated with Microtubules and Spatially Separated from eIF4E Granules and P Bodies in Human Neuronal Processes. Frontiers in molecular biosciences, 4, 93 Frontiers in molecular biosciences, 4, 93 Frontiers in molecular biosciences, 4, 93 2017 公開
Candeias MM, Hagiwara M, Matsuda M Candeias MM, Hagiwara M, Matsuda M Candeias MM, Hagiwara M, Matsuda M Cancer-specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis. Cancer-specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis. Cancer-specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis. EMBO reports, 17, 11, 1542-1551 EMBO reports, 17, 11, 1542-1551 EMBO reports, 17, 11, 1542-1551 2016/11 公開
Tanaka T, Okuyama-Dobashi K, Murakami S, Chen W, Okamoto T, Ueda K, Hosoya T, Matsuura Y, Ryo A, Tanaka Y, Hagiwara M, Moriishi K Tanaka T, Okuyama-Dobashi K, Murakami S, Chen W, Okamoto T, Ueda K, Hosoya T, Matsuura Y, Ryo A, Tanaka Y, Hagiwara M, Moriishi K Tanaka T, Okuyama-Dobashi K, Murakami S, Chen W, Okamoto T, Ueda K, Hosoya T, Matsuura Y, Ryo A, Tanaka Y, Hagiwara M, Moriishi K Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation. Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation. Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation. Antiviral research, 133, 156-164 Antiviral research, 133, 156-164 Antiviral research, 133, 156-164 2016/09 公開
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Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, Kii I, Nishiyama T, Kakita A, Takeda H, Takeuchi A, Arai Y, Ito A, Komura H, Hirao H, Satomura K, Inoue M, Muramatsu S, Matsui K, Tada M, Sato M, Saijo E, Shigemitsu Y, Sakai S, Umetsu Y, Goda N, Takino N, Takahashi H, Hagiwara M, Sawasaki T, Iwasaki G, Nakamura Y, Nabeshima Y, Teplow DB, Hoshi M Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, Kii I, Nishiyama T, Kakita A, Takeda H, Takeuchi A, Arai Y, Ito A, Komura H, Hirao H, Satomura K, Inoue M, Muramatsu S, Matsui K, Tada M, Sato M, Saijo E, Shigemitsu Y, Sakai S, Umetsu Y, Goda N, Takino N, Takahashi H, Hagiwara M, Sawasaki T, Iwasaki G, Nakamura Y, Nabeshima Y, Teplow DB, Hoshi M Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, Kii I, Nishiyama T, Kakita A, Takeda H, Takeuchi A, Arai Y, Ito A, Komura H, Hirao H, Satomura K, Inoue M, Muramatsu S, Matsui K, Tada M, Sato M, Saijo E, Shigemitsu Y, Sakai S, Umetsu Y, Goda N, Takino N, Takahashi H, Hagiwara M, Sawasaki T, Iwasaki G, Nakamura Y, Nabeshima Y, Teplow DB, Hoshi M Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly. Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly. Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly. Proceedings of the National Academy of Sciences of the United States of America, 112, 32, E4465-74 Proceedings of the National Academy of Sciences of the United States of America, 112, 32, E4465-74 Proceedings of the National Academy of Sciences of the United States of America, 112, 32, E4465-74 2015/08 公開
Ohe K, Hagiwara M Ohe K, Hagiwara M Ohe K, Hagiwara M Modulation of alternative splicing with chemical compounds in new therapeutics for human diseases. Modulation of alternative splicing with chemical compounds in new therapeutics for human diseases. Modulation of alternative splicing with chemical compounds in new therapeutics for human diseases. ACS chemical biology, 10, 4, 914-924 ACS chemical biology, 10, 4, 914-924 ACS chemical biology, 10, 4, 914-924 2015/04 公開
Yoshida M, Kataoka N, Miyauchi K, Ohe K, Iida K, Yoshida S, Nojima T, Okuno Y, Onogi H, Usui T, Takauchi A, Hosoya T, Suzuki T, and Hagiwara M, Yoshida M, Kataoka N, Miyauchi K, Ohe K, Iida K, Yoshida S, Nojima T, Okuno Y, Onogi H, Usui T, Takauchi A, Hosoya T, Suzuki T, and Hagiwara M, 3. Yoshida M, Kataoka N, Miyauchi K, Ohe K, Iida K, Yoshida S, Nojima T, Okuno Y, Onogi H, Usui T, Takauchi A, Hosoya T, Suzuki T, and Hagiwara M, Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia. Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia. Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia. Proc Natl Acad Sci USA., 112, 9, 2764-2769 Proc Natl Acad Sci USA., 112, 9, 2764-2769 Proc Natl Acad Sci USA., 112, 9, 2764-2769 2015/03 公開
Kuwasako K, Takahashi M, Unzai S, Tsuda K, Yoshikawa S, He F, Kobayashi N, Güntert P, Shirouzu M, Ito T, Tanaka A, Yokoyama S, Hagiwara M, Kuroyanagi H, and Muto Y. Kuwasako K, Takahashi M, Unzai S, Tsuda K, Yoshikawa S, He F, Kobayashi N, Güntert P, Shirouzu M, Ito T, Tanaka A, Yokoyama S, Hagiwara M, Kuroyanagi H, and Muto Y. 4. Kuwasako K, Takahashi M, Unzai S, Tsuda K, Yoshikawa S, He F, Kobayashi N, Güntert P, Shirouzu M, Ito T, Tanaka A, Yokoyama S, Hagiwara M, Kuroyanagi H, and Muto Y. RBFOX and SUP-12 sandwich a guanine base to form a stable complex and regulate tissue-specific splicing RBFOX and SUP-12 sandwich a guanine base to form a stable complex and regulate tissue-specific splicing RBFOX and SUP-12 sandwich a guanine base to form a stable complex and regulate tissue-specific splicing Nat. Struct. Mol. Biol., 21, 9, 778-786 Nat. Struct. Mol. Biol., 21, 9, 778-786 Nat. Struct. Mol. Biol., 21, 9, 778-786 2014/09 公開
Yamamoto M, Onogi H, Kii I, Yoshida S, Iida K, Sakai H, Abe M, Tsubota T,Ito N, Hosoya T, and Hagiwara M. Yamamoto M, Onogi H, Kii I, Yoshida S, Iida K, Sakai H, Abe M, Tsubota T,Ito N, Hosoya T, and Hagiwara M. Yamamoto M, Onogi H, Kii I, Yoshida S, Iida K, Sakai H, Abe M, Tsubota T,Ito N, Hosoya T, and Hagiwara M. CDK9 inhibitor FIT-039 prevents replication of multiple CDK9 inhibitor FIT-039 prevents replication of multiple CDK9 inhibitor FIT-039 prevents replication of multiple J Clin Invest., 124, 8, 3479-3488 J Clin Invest., 124, 8, 3479-3488 J Clin Invest., 124, 8, 3479-3488 2014/08 英語 公開
Kurihara T, Sakurai E, Toyomoto M, Kii I, Kawamoto D, Asada T, Tanabe T, Yoshimura M, Hagiwara M, Miyata A. Kurihara T, Sakurai E, Toyomoto M, Kii I, Kawamoto D, Asada T, Tanabe T, Yoshimura M, Hagiwara M, Miyata A. Kurihara T, Sakurai E, Toyomoto M, Kii I, Kawamoto D, Asada T, Tanabe T, Yoshimura M, Hagiwara M, Miyata A. Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors. Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors. Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors. Mol Pain., 10, 17 Mol Pain., 10, 17 Mol Pain., 10, 17 2014/03 英語 公開
Gammons MV, Fedorov O, Ivison D, Du C, Clark T, Hopkins C, Hagiwara M, Dick AD, Cox R, Harper SJ, Hancox JC, Knapp S, Bates DO. Gammons MV, Fedorov O, Ivison D, Du C, Clark T, Hopkins C, Hagiwara M, Dick AD, Cox R, Harper SJ, Hancox JC, Knapp S, Bates DO. Gammons MV, Fedorov O, Ivison D, Du C, Clark T, Hopkins C, Hagiwara M, Dick AD, Cox R, Harper SJ, Hancox JC, Knapp S, Bates DO. Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD. Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD. Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD. Invest Ophthalmol Vis Sci., 54, 9, 6052-6062 Invest Ophthalmol Vis Sci., 54, 9, 6052-6062 Invest Ophthalmol Vis Sci., 54, 9, 6052-6062 2013/09 英語 公開
Pozo N, Zahonero C, Fernández P, Liñares JM, Ayuso A, Hagiwara M, Pérez A, Ricoy JR, Hernández-Laín A, Sepúlveda JM, Sánchez-Gómez P Pozo N, Zahonero C, Fernández P, Liñares JM, Ayuso A, Hagiwara M, Pérez A, Ricoy JR, Hernández-Laín A, Sepúlveda JM, Sánchez-Gómez P Pozo N, Zahonero C, Fernández P, Liñares JM, Ayuso A, Hagiwara M, Pérez A, Ricoy JR, Hernández-Laín A, Sepúlveda JM, Sánchez-Gómez P Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. J Clin Invest. doi:pii: 63623. 10.1172/JCI63623., 123, 6, 2475-2487 J Clin Invest. doi:pii: 63623. 10.1172/JCI63623., 123, 6, 2475-2487 J Clin Invest. doi:pii: 63623. 10.1172/JCI63623., 123, 6, 2475-2487 2013/06 英語 研究論文(学術雑誌) 公開
Kuroyanagi H, Watanabe Y, Suzuki Y, and Hagiwara M. (2013) Kuroyanagi H, Watanabe Y, Suzuki Y, and Hagiwara M. (2013) Kuroyanagi H, Watanabe Y, Suzuki Y, and Hagiwara M. (2013) Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans. Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans. Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans. Nucleic. Acids Res. 41(7):4015-4025., 41, 7, 4015-4025 Nucleic. Acids Res. 41(7):4015-4025., 41, 7, 4015-4025 Nucleic. Acids Res. 41(7):4015-4025., 41, 7, 4015-4025 2013/04 英語 研究論文(学術雑誌) 公開
Kataoka N, Dobashi I, Hagiwara M, and Ohno M Kataoka N, Dobashi I, Hagiwara M, and Ohno M Kataoka N, Dobashi I, Hagiwara M, and Ohno M hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity. hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity. hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity. Sci Rep 3, 1090., 3, 1090 Sci Rep 3, 1090., 3, 1090 Sci Rep 3, 1090., 3, 1090 2013 英語 研究論文(学術雑誌) 公開
Kuroyanagi H, Watanabe Y, and Hagiwara M Kuroyanagi H, Watanabe Y, and Hagiwara M Kuroyanagi H, Watanabe Y, and Hagiwara M CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans. CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans. CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans. PLoS Genet. 9(2):e1003337, 9, 2, e1003337 PLoS Genet. 9(2):e1003337, 9, 2, e1003337 PLoS Genet. 9(2):e1003337, 9, 2, e1003337 2013 英語 研究論文(学術雑誌) 公開
Dong Z, Noda K, Kanda A, Fukuhara J, Ando R, Murata M, Saito W, Hagiwara M, Ishida S Dong Z, Noda K, Kanda A, Fukuhara J, Ando R, Murata M, Saito W, Hagiwara M, Ishida S Dong Z, Noda K, Kanda A, Fukuhara J, Ando R, Murata M, Saito W, Hagiwara M, Ishida S Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization. Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization. Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization. Mol Vis. 19:536-543, 19, 536-543 Mol Vis. 19:536-543, 19, 536-543 Mol Vis. 19:536-543, 19, 536-543 2013 英語 研究論文(学術雑誌) 公開
Ogawa Y, Hagiwara M Ogawa Y, Hagiwara M Ogawa Y, Hagiwara M Challenges to congenital genetic disorders with "RNA-targeting" chemical compounds. Challenges to congenital genetic disorders with "RNA-targeting" chemical compounds. Challenges to congenital genetic disorders with "RNA-targeting" chemical compounds. Pharmacology & therapeutics, 134, 3, 298-305 Pharmacology & therapeutics, 134, 3, 298-305 Pharmacology & therapeutics, 134, 3, 298-305 2012/06 公開
Saitoh N, Sakamoto C, Hagiwara M, Agredano-Moreno LT, Jiménez-García LF, Nakao M Saitoh N, Sakamoto C, Hagiwara M, Agredano-Moreno LT, Jiménez-García LF, Nakao M Saitoh N, Sakamoto C, Hagiwara M, Agredano-Moreno LT, Jiménez-García LF, Nakao M The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2 The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2 The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2 Mol Biol Cell. 23(6):1115-28, 23, 6, 1115-1128 Mol Biol Cell. 23(6):1115-28, 23, 6, 1115-1128 Mol Biol Cell. 23(6):1115-28, 23, 6, 1115-1128 2012/03 英語 研究論文(学術雑誌) 公開
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Nishida A, Kataoka N, Takeshima Y, Yagi M, Awano, H, Ota, M, Itoh K, Hagiwara M, and Matsuo M Nishida A, Kataoka N, Takeshima Y, Yagi M, Awano, H, Ota, M, Itoh K, Hagiwara M, and Matsuo M Nishida A, Kataoka N, Takeshima Y, Yagi M, Awano, H, Ota, M, Itoh K, Hagiwara M, and Matsuo M Chemical treatment enhances skipping of a mutated exon in the dystrophin gene. Chemical treatment enhances skipping of a mutated exon in the dystrophin gene. Chemical treatment enhances skipping of a mutated exon in the dystrophin gene. Nature Commun 2, 308, 2, 308 Nature Commun 2, 308, 2, 308 Nature Commun 2, 308, 2, 308 2011 英語 研究論文(学術雑誌) 公開
Kataoka N, Diem MD, Yoshida M, Hatai C, Dobashi I, Dreyfuss G, Hagiwara M, Ohno M Kataoka N, Diem MD, Yoshida M, Hatai C, Dobashi I, Dreyfuss G, Hagiwara M, Ohno M Kataoka N, Diem MD, Yoshida M, Hatai C, Dobashi I, Dreyfuss G, Hagiwara M, Ohno M Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA. Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA. Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA. Scientific reports, 1, 92 Scientific reports, 1, 92 Scientific reports, 1, 92 2011 公開
Anwar A, Hosoya T, Leong KM, Onogi H, Okuno Y, Hiramatsu T, Koyama H, Suzuki M, Hagiwara M, Garcia-Blanco MA Anwar A, Hosoya T, Leong KM, Onogi H, Okuno Y, Hiramatsu T, Koyama H, Suzuki M, Hagiwara M, Garcia-Blanco MA Anwar A, Hosoya T, Leong KM, Onogi H, Okuno Y, Hiramatsu T, Koyama H, Suzuki M, Hagiwara M, Garcia-Blanco MA The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly. The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly. The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly. PloS one, 6, 8, e23246 PloS one, 6, 8, e23246 PloS one, 6, 8, e23246 2011 公開
Ogawa Y, Nonaka Y, Goto T, Ohnishi E, Hiramatsu T, Kii I, Yoshida M, Ikura T, Onogi H, Shibuya H, Hosoya T, Ito N, Hagiwara M Ogawa Y, Nonaka Y, Goto T, Ohnishi E, Hiramatsu T, Kii I, Yoshida M, Ikura T, Onogi H, Shibuya H, Hosoya T, Ito N, Hagiwara M Ogawa Y, Nonaka Y, Goto T, Ohnishi E, Hiramatsu T, Kii I, Yoshida M, Ikura T, Onogi H, Shibuya H, Hosoya T, Ito N, Hagiwara M Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nature communications, 1, 86 Nature communications, 1, 86 Nature communications, 1, 86 2010/10 公開
* Kii, I., Shiraishi, A., Hiramatsu, T., Matsushita, T., Uekusa, H., Yoshida, S., Yamamoto, M., Kudo, A., Hagiwara, M., and Hosoya, T. * Kii, I., Shiraishi, A., Hiramatsu, T., Matsushita, T., Uekusa, H., Yoshida, S., Yamamoto, M., Kudo, A., Hagiwara, M., and Hosoya, T. * Kii, I., Shiraishi, A., Hiramatsu, T., Matsushita, T., Uekusa, H., Yoshida, S., Yamamoto, M., Kudo, A., Hagiwara, M., and Hosoya, T. Strain-promoted double-click reaction for chemical modification of azido-biomolecules. Org Biomol Chem 8, 4051-4055. Strain-promoted double-click reaction for chemical modification of azido-biomolecules. Org Biomol Chem 8, 4051-4055. Strain-promoted double-click reaction for chemical modification of azido-biomolecules. Org Biomol Chem 8, 4051-4055. Organic & biomolecular chemistry, 8, 18, 4051-4055 Organic & biomolecular chemistry, 8, 18, 4051-4055 Organic & biomolecular chemistry, 8, 18, 4051-4055 2010/09 英語 研究論文(学術雑誌) 公開
Kuroyanagi H, Ohno G, Sakane H, Maruoka H, Hagiwara M Kuroyanagi H, Ohno G, Sakane H, Maruoka H, Hagiwara M Kuroyanagi H, Ohno G, Sakane H, Maruoka H, Hagiwara M Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans. Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans. Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans. Nature protocols, 5, 9, 1495-1517 Nature protocols, 5, 9, 1495-1517 Nature protocols, 5, 9, 1495-1517 2010/09 公開
Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Nishimura-Sakurai Y, Kakinuma S, Oooka M, Azuma S, Tsuchiya K, Onogi H, Hagiwara M, Watanabe M Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Nishimura-Sakurai Y, Kakinuma S, Oooka M, Azuma S, Tsuchiya K, Onogi H, Hagiwara M, Watanabe M Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Nishimura-Sakurai Y, Kakinuma S, Oooka M, Azuma S, Tsuchiya K, Onogi H, Hagiwara M, Watanabe M Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Antimicrobial agents and chemotherapy, 54, 8, 3179-3186 Antimicrobial agents and chemotherapy, 54, 8, 3179-3186 Antimicrobial agents and chemotherapy, 54, 8, 3179-3186 2010/08 公開
Takeuchi A, Hosokawa M, Nojima T, Hagiwara M Takeuchi A, Hosokawa M, Nojima T, Hagiwara M Takeuchi A, Hosokawa M, Nojima T, Hagiwara M Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection. Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection. Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection. PloS one, 5, 6, e10946 PloS one, 5, 6, e10946 PloS one, 5, 6, e10946 2010/06 公開
* Nowak DG, Amin EM, Rennel ES, Hoareau-Aveilla C, Gammons M, Damodoran G, Hagiwara M, Harper SJ, Woolard J, Ladomery MR, and Bates DO. * Nowak DG, Amin EM, Rennel ES, Hoareau-Aveilla C, Gammons M, Damodoran G, Hagiwara M, Harper SJ, Woolard J, Ladomery MR, and Bates DO. Nowak DG, Amin EM, Rennel ES, Hoareau-Aveilla C, Gammons M, Damodoran G, Hagiwara M, Harper SJ, Woolard J, Ladomery MR, Bates DO Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms - a novel therapeutic strategy for angiogenesis. J. Biol. Chem. 285, 5532-5540. Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms - a novel therapeutic strategy for angiogenesis. J. Biol. Chem. 285, 5532-5540. Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis. The Journal of biological chemistry, 285, 8, 5532-5540 The Journal of biological chemistry, 285, 8, 5532-5540 The Journal of biological chemistry, 285, 8, 5532-5540 2010/02 日本語 研究論文(学術雑誌) 公開
*Ogawa Y, Nonaka Y, Goto T, Ohnishi E, Hiramatsu T, Kii I, Yoshida M , Ikura T , Onogi H , Shibuya H , Hosoya T, Ito N, and Hagiwara M (2010) *Ogawa Y, Nonaka Y, Goto T, Ohnishi E, Hiramatsu T, Kii I, Yoshida M , Ikura T , Onogi H , Shibuya H , Hosoya T, Ito N, and Hagiwara M (2010) *Ogawa Y, Nonaka Y, Goto T, Ohnishi E, Hiramatsu T, Kii I, Yoshida M , Ikura T , Onogi H , Shibuya H , Hosoya T, Ito N, and Hagiwara M (2010) Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nature Commun.1 ,Article number: 86, doi:10.1038/ncomms1090 Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nature Commun.1 ,Article number: 86, doi:10.1038/ncomms1090 Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nature Commun.1 ,Article number: 86, doi:10.1038/ncomms1090 2010 英語 研究論文(学術雑誌) 公開
*Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Nishimura-Sakurai Y, Kakinuma S, Oooka M, Azuma S, Tsuchiya K, Onogi H, Hagiwara M, and Watanabe M. *Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Nishimura-Sakurai Y, Kakinuma S, Oooka M, Azuma S, Tsuchiya K, Onogi H, Hagiwara M, and Watanabe M. *Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Nishimura-Sakurai Y, Kakinuma S, Oooka M, Azuma S, Tsuchiya K, Onogi H, Hagiwara M, and Watanabe M. Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Antimicrob Agents Chemother. 54, 3179-3186 Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Antimicrob Agents Chemother. 54, 3179-3186 Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Antimicrob Agents Chemother. 54, 3179-3186 2010 英語 研究論文(学術雑誌) 公開
*Takeuchi A, Hosokawa M, Nojima T, Hagiwara M *Takeuchi A, Hosokawa M, Nojima T, Hagiwara M *Takeuchi A, Hosokawa M, Nojima T, Hagiwara M Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative splicing. PLOS One 5, e10946 Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative splicing. PLOS One 5, e10946 Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative splicing. PLOS One 5, e10946 2010 英語 研究論文(学術雑誌) 公開
*Kuroyanagi, H., Ohno, G., Sakane, H., Maruoka, H., and Hagiwara, M. *Kuroyanagi, H., Ohno, G., Sakane, H., Maruoka, H., and Hagiwara, M. *Kuroyanagi, H., Ohno, G., Sakane, H., Maruoka, H., and Hagiwara, M. Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans. Nat Protoc 5, 1495-1517. Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans. Nat Protoc 5, 1495-1517. Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans. Nat Protoc 5, 1495-1517. 2010 英語 研究論文(学術雑誌) 公開
* Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimoto M, Kawaguchi Y, Kataoka N and Hagiwara M * Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimoto M, Kawaguchi Y, Kataoka N and Hagiwara M * Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimoto M, Kawaguchi Y, Kataoka N and Hagiwara M Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing. Nucleic. Acids Res. 37, 6515-6527. Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing. Nucleic. Acids Res. 37, 6515-6527. Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing. Nucleic. Acids Res. 37, 6515-6527. Nucleic acids research, 37, 19, 6515-6527 Nucleic acids research, 37, 19, 6515-6527 Nucleic acids research, 37, 19, 6515-6527 2009/10 英語 研究論文(学術雑誌) 公開
*Jiang K, Patel NA, Watson JE, Apostolatos H, Kleiman E, Hanson O, Hagiwara M, Cooper DR. *Jiang K, Patel NA, Watson JE, Apostolatos H, Kleiman E, Hanson O, Hagiwara M, Cooper DR. Jiang K, Patel NA, Watson JE, Apostolatos H, Kleiman E, Hanson O, Hagiwara M, Cooper DR Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCβII mRNA. Endocrinology, 150, 2087-2097. Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCβII mRNA. Endocrinology, 150, 2087-2097. Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCbetaII messenger ribonucleic acid. Endocrinology, 150, 5, 2087-2097 Endocrinology, 150, 5, 2087-2097 Endocrinology, 150, 5, 2087-2097 2009/05 日本語 研究論文(学術雑誌) 公開
Hagiwara M Hagiwara M Hagiwara M [Development of protein kinase inhibitors and their applications for chemical biology]. [Development of protein kinase inhibitors and their applications for chemical biology]. [Development of protein kinase inhibitors and their applications for chemical biology]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 132, 1, 22-25 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 132, 1, 22-25 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 132, 1, 22-25 2008/07 公開
Hagiwara M Hagiwara M Hagiwara M [Overview of chemical biology]. [Overview of chemical biology]. [Overview of chemical biology]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 132, 1, 4-6 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 132, 1, 4-6 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 132, 1, 4-6 2008/07 公開
* Yomoda, J., Muraki, M., Kataoka, N., Hosoya, T., Suzuki, M., Hagiwara, M. and Kimura, H. * Yomoda, J., Muraki, M., Kataoka, N., Hosoya, T., Suzuki, M., Hagiwara, M. and Kimura, H. * Yomoda, J., Muraki, M., Kataoka, N., Hosoya, T., Suzuki, M., Hagiwara, M. and Kimura, H. Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A. Genes Cells, 13, 233-244. Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A. Genes Cells, 13, 233-244. Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A. Genes Cells, 13, 233-244. Genes to cells : devoted to molecular & cellular mechanisms, 13, 3, 233-244 Genes to cells : devoted to molecular & cellular mechanisms, 13, 3, 233-244 Genes to cells : devoted to molecular & cellular mechanisms, 13, 3, 233-244 2008/03 英語 研究論文(学術雑誌) 公開
*Ohno, G., Hagiwara, M. and Kuroyanagi, H. *Ohno, G., Hagiwara, M. and Kuroyanagi, H. *Ohno, G., Hagiwara, M. and Kuroyanagi, H. STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo. Genes & Dev., 22,360-374. STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo. Genes & Dev., 22,360-374. STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo. Genes & Dev., 22,360-374. Genes & development, 22, 3, 360-374 Genes & development, 22, 3, 360-374 Genes & development, 22, 3, 360-374 2008/02 英語 研究論文(学術雑誌) 公開
Kuroyanagi H, Ohno G, Mitani S, Hagiwara M Kuroyanagi H, Ohno G, Mitani S, Hagiwara M Kuroyanagi H, Ohno G, Mitani S, Hagiwara M The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo. The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo. The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo. Molecular and cellular biology, 27, 24, 8612-8621 Molecular and cellular biology, 27, 24, 8612-8621 Molecular and cellular biology, 27, 24, 8612-8621 2007/12 公開
Hagiwara M, Usuki H Hagiwara M, Usuki H Hagiwara M, Usuki H [Kinase inhibitors]. [Kinase inhibitors]. [Kinase inhibitors]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1708-1712 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1708-1712 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1708-1712 2007/10 公開
Kaida D, Motoyoshi H, Tashiro E, Nojima T, Hagiwara M, Ishigami K, Watanabe H, Kitahara T, Yoshida T, Nakajima H, Tani T, Horinouchi S, Yoshida M Kaida D, Motoyoshi H, Tashiro E, Nojima T, Hagiwara M, Ishigami K, Watanabe H, Kitahara T, Yoshida T, Nakajima H, Tani T, Horinouchi S, Yoshida M Kaida D, Motoyoshi H, Tashiro E, Nojima T, Hagiwara M, Ishigami K, Watanabe H, Kitahara T, Yoshida T, Nakajima H, Tani T, Horinouchi S, Yoshida M Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nature chemical biology, 3, 9, 576-583 Nature chemical biology, 3, 9, 576-583 Nature chemical biology, 3, 9, 576-583 2007/09 公開
Ideue T, Sasaki YT, Hagiwara M, Hirose T Ideue T, Sasaki YT, Hagiwara M, Hirose T Ideue T, Sasaki YT, Hagiwara M, Hirose T Introns play an essential role in splicing-dependent formation of the exon junction complex. Introns play an essential role in splicing-dependent formation of the exon junction complex. Introns play an essential role in splicing-dependent formation of the exon junction complex. Genes & development, 21, 16, 1993-1998 Genes & development, 21, 16, 1993-1998 Genes & development, 21, 16, 1993-1998 2007/08 公開
Hagiwara M, Nojima T Hagiwara M, Nojima T Hagiwara M, Nojima T Cross-talks between transcription and post-transcriptional events within a 'mRNA factory'. Cross-talks between transcription and post-transcriptional events within a 'mRNA factory'. Cross-talks between transcription and post-transcriptional events within a 'mRNA factory'. Journal of biochemistry, 142, 1, 11-15 Journal of biochemistry, 142, 1, 11-15 Journal of biochemistry, 142, 1, 11-15 2007/07 公開
Aida T, Konishi A, Hagiwara M, Hashimoto K Aida T, Konishi A, Hagiwara M, Hashimoto K Aida T, Konishi A, Hagiwara M, Hashimoto K Shortened life spans of biotech pioneer patents in Japan: a lesson from the DNA chip. Shortened life spans of biotech pioneer patents in Japan: a lesson from the DNA chip. Shortened life spans of biotech pioneer patents in Japan: a lesson from the DNA chip. Nature biotechnology, 25, 5, 533-535 Nature biotechnology, 25, 5, 533-535 Nature biotechnology, 25, 5, 533-535 2007/05 公開
Nojima T, Hirose T, Kimura H, Hagiwara M Nojima T, Hirose T, Kimura H, Hagiwara M Nojima T, Hirose T, Kimura H, Hagiwara M The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export. The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export. The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export. The Journal of biological chemistry, 282, 21, 15645-15651 The Journal of biological chemistry, 282, 21, 15645-15651 The Journal of biological chemistry, 282, 21, 15645-15651 2007/05 公開
Kimura H, Takizawa N, Allemand E, Hori T, Iborra FJ, Nozaki N, Muraki M, Hagiwara M, Krainer AR, Fukagawa T, Okawa K Kimura H, Takizawa N, Allemand E, Hori T, Iborra FJ, Nozaki N, Muraki M, Hagiwara M, Krainer AR, Fukagawa T, Okawa K Kimura H, Takizawa N, Allemand E, Hori T, Iborra FJ, Nozaki N, Muraki M, Hagiwara M, Krainer AR, Fukagawa T, Okawa K A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B. A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B. A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B. The Journal of cell biology, 175, 3, 389-400 The Journal of cell biology, 175, 3, 389-400 The Journal of cell biology, 175, 3, 389-400 2006/11 公開
Kuroyanagi H, Kobayashi T, Mitani S, Hagiwara M Kuroyanagi H, Kobayashi T, Mitani S, Hagiwara M Kuroyanagi H, Kobayashi T, Mitani S, Hagiwara M Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo. Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo. Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo. Nature methods, 3, 11, 909-915 Nature methods, 3, 11, 909-915 Nature methods, 3, 11, 909-915 2006/11 公開
Wada K, Howard JT, McConnell P, Whitney O, Lints T, Rivas MV, Horita H, Patterson MA, White SA, Scharff C, Haesler S, Zhao S, Sakaguchi H, Hagiwara M, Shiraki T, Hirozane-Kishikawa T, Skene P, Hayashizaki Y, Carninci P, Jarvis ED Wada K, Howard JT, McConnell P, Whitney O, Lints T, Rivas MV, Horita H, Patterson MA, White SA, Scharff C, Haesler S, Zhao S, Sakaguchi H, Hagiwara M, Shiraki T, Hirozane-Kishikawa T, Skene P, Hayashizaki Y, Carninci P, Jarvis ED Wada K, Howard JT, McConnell P, Whitney O, Lints T, Rivas MV, Horita H, Patterson MA, White SA, Scharff C, Haesler S, Zhao S, Sakaguchi H, Hagiwara M, Shiraki T, Hirozane-Kishikawa T, Skene P, Hayashizaki Y, Carninci P, Jarvis ED A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes. A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes. A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes. Proceedings of the National Academy of Sciences of the United States of America, 103, 41, 15212-15217 Proceedings of the National Academy of Sciences of the United States of America, 103, 41, 15212-15217 Proceedings of the National Academy of Sciences of the United States of America, 103, 41, 15212-15217 2006/10 公開
Hirose T, Ideue T, Nagai M, Hagiwara M, Shu MD, Steitz JA Hirose T, Ideue T, Nagai M, Hagiwara M, Shu MD, Steitz JA Hirose T, Ideue T, Nagai M, Hagiwara M, Shu MD, Steitz JA A spliceosomal intron binding protein, IBP160, links position-dependent assembly of intron-encoded box C/D snoRNP to pre-mRNA splicing. A spliceosomal intron binding protein, IBP160, links position-dependent assembly of intron-encoded box C/D snoRNP to pre-mRNA splicing. A spliceosomal intron binding protein, IBP160, links position-dependent assembly of intron-encoded box C/D snoRNP to pre-mRNA splicing. Molecular cell, 23, 5, 673-684 Molecular cell, 23, 5, 673-684 Molecular cell, 23, 5, 673-684 2006/09 公開
Fukuhara T, Hosoya T, Shimizu S, Sumi K, Oshiro T, Yoshinaka Y, Suzuki M, Yamamoto N, Herzenberg LA, Herzenberg LA, Hagiwara M Fukuhara T, Hosoya T, Shimizu S, Sumi K, Oshiro T, Yoshinaka Y, Suzuki M, Yamamoto N, Herzenberg LA, Herzenberg LA, Hagiwara M Fukuhara T, Hosoya T, Shimizu S, Sumi K, Oshiro T, Yoshinaka Y, Suzuki M, Yamamoto N, Herzenberg LA, Herzenberg LA, Hagiwara M Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proceedings of the National Academy of Sciences of the United States of America, 103, 30, 11329-11333 Proceedings of the National Academy of Sciences of the United States of America, 103, 30, 11329-11333 Proceedings of the National Academy of Sciences of the United States of America, 103, 30, 11329-11333 2006/07 公開
Hagiwara M Hagiwara M Hagiwara M Alternative splicing: a new drug target of the post-genome era. Alternative splicing: a new drug target of the post-genome era. Alternative splicing: a new drug target of the post-genome era. Biochimica et biophysica acta, 1754, 1-2, 324-331 Biochimica et biophysica acta, 1754, 1-2, 324-331 Biochimica et biophysica acta, 1754, 1-2, 324-331 2005/12 公開
Ohki N, Hagiwara M Ohki N, Hagiwara M Ohki N, Hagiwara M Bio-Object, a stochastic simulator for post-transcriptional regulation. Bio-Object, a stochastic simulator for post-transcriptional regulation. Bio-Object, a stochastic simulator for post-transcriptional regulation. Bioinformatics (Oxford, England), 21, 10, 2478-2487 Bioinformatics (Oxford, England), 21, 10, 2478-2487 Bioinformatics (Oxford, England), 21, 10, 2478-2487 2005/05 公開
Wada K, Sakaguchi H, Jarvis ED, Hagiwara M Wada K, Sakaguchi H, Jarvis ED, Hagiwara M Wada K, Sakaguchi H, Jarvis ED, Hagiwara M Differential expression of glutamate receptors in avian neural pathways for learned vocalization. Differential expression of glutamate receptors in avian neural pathways for learned vocalization. Differential expression of glutamate receptors in avian neural pathways for learned vocalization. The Journal of comparative neurology, 476, 1, 44-64 The Journal of comparative neurology, 476, 1, 44-64 The Journal of comparative neurology, 476, 1, 44-64 2004/08 公開
Takano M, Koyama Y, Ito H, Hoshino S, Onogi H, Hagiwara M, Furukawa K, Horigome T Takano M, Koyama Y, Ito H, Hoshino S, Onogi H, Hagiwara M, Furukawa K, Horigome T Takano M, Koyama Y, Ito H, Hoshino S, Onogi H, Hagiwara M, Furukawa K, Horigome T Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts. Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts. Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts. The Journal of biological chemistry, 279, 13, 13265-13271 The Journal of biological chemistry, 279, 13, 13265-13271 The Journal of biological chemistry, 279, 13, 13265-13271 2004/03 公開
Inoue K, Zama T, Kamimoto T, Aoki R, Ikeda Y, Kimura H, Hagiwara M Inoue K, Zama T, Kamimoto T, Aoki R, Ikeda Y, Kimura H, Hagiwara M Inoue K, Zama T, Kamimoto T, Aoki R, Ikeda Y, Kimura H, Hagiwara M TNFalpha-induced ATF3 expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells. TNFalpha-induced ATF3 expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells. TNFalpha-induced ATF3 expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells. Genes to cells : devoted to molecular & cellular mechanisms, 9, 1, 59-70 Genes to cells : devoted to molecular & cellular mechanisms, 9, 1, 59-70 Genes to cells : devoted to molecular & cellular mechanisms, 9, 1, 59-70 2004/01 公開
Suzuki H, Wu J, Hossain K, Ohhata T, Du J, Akhand AA, Hayakawa A, Kimura H, Hagiwara M, Nakashima I Suzuki H, Wu J, Hossain K, Ohhata T, Du J, Akhand AA, Hayakawa A, Kimura H, Hagiwara M, Nakashima I Suzuki H, Wu J, Hossain K, Ohhata T, Du J, Akhand AA, Hayakawa A, Kimura H, Hagiwara M, Nakashima I Involvement of MKK6 in TCRalphabeta(int)CD69lo: a target population for apoptotic cell death in thymocytes. Involvement of MKK6 in TCRalphabeta(int)CD69lo: a target population for apoptotic cell death in thymocytes. Involvement of MKK6 in TCRalphabeta(int)CD69lo: a target population for apoptotic cell death in thymocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 17, 11, 1538-1540 FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 17, 11, 1538-1540 FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 17, 11, 1538-1540 2003/08 公開
Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. Biochemical and biophysical research communications, 301, 2, 324-329 Biochemical and biophysical research communications, 301, 2, 324-329 Biochemical and biophysical research communications, 301, 2, 324-329 2003/02 公開
Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. Biochemical and biophysical research communications, 301, 2, 324-329 Biochemical and biophysical research communications, 301, 2, 324-329 Biochemical and biophysical research communications, 301, 2, 324-329 2003/02 公開
Suzuki T, Yamakuni T, Hagiwara M, Ichinose H Suzuki T, Yamakuni T, Hagiwara M, Ichinose H Suzuki T, Yamakuni T, Hagiwara M, Ichinose H Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene. Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene. Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene. The Journal of biological chemistry, 277, 43, 40768-40774 The Journal of biological chemistry, 277, 43, 40768-40774 The Journal of biological chemistry, 277, 43, 40768-40774 2002/10 公開
Wada K, Inoue K, Hagiwara M Wada K, Inoue K, Hagiwara M Wada K, Inoue K, Hagiwara M Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy. Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy. Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy. Biochimica et biophysica acta, 1591, 1-3, 1-10 Biochimica et biophysica acta, 1591, 1-3, 1-10 Biochimica et biophysica acta, 1591, 1-3, 1-10 2002/08 公開
Wada K, Inoue K, Hagiwara M Wada K, Inoue K, Hagiwara M Wada K, Inoue K, Hagiwara M Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy. Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy. Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy. Biochimica et biophysica acta, 1591, 1-3, 1-10 Biochimica et biophysica acta, 1591, 1-3, 1-10 Biochimica et biophysica acta, 1591, 1-3, 1-10 2002/08 公開
Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, Hagiwara M Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, Hagiwara M Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, Hagiwara M Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway. Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway. Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway. The Journal of biological chemistry, 277, 26, 23919-23926 The Journal of biological chemistry, 277, 26, 23919-23926 The Journal of biological chemistry, 277, 26, 23919-23926 2002/06 公開
Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, Hagiwara M Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, Hagiwara M Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, Hagiwara M A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway. A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway. A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway. The Journal of biological chemistry, 277, 26, 23909-23918 The Journal of biological chemistry, 277, 26, 23909-23918 The Journal of biological chemistry, 277, 26, 23909-23918 2002/06 公開

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タイトル言語:
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著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Manipulation of alternative splicing by a newly developed inhibitor of Clks. Manipulation of alternative splicing by a newly developed inhibitor of Clks. J. Biol. Chem., 279, 24246-24254. J. Biol. Chem., 279, 24246-24254. , 279, 24246-24254. 2004 公開
A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elogans A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elogans EMBO Rep, 3, 962-966 EMBO Rep, 3, 962-966 , 3, 962-966 2002 公開
NAGAI Y, MIYAZAKI M, AOKI R, ZAMA T, INOUYE S, HIROSE K, IINO M, HAGIWARA M NAGAI Y, MIYAZAKI M, AOKI R, ZAMA T, INOUYE S, HIROSE K, IINO M, HAGIWARA M A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo. A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo. Nat. Biotechnol, 18, 3, 313-316 Nat. Biotechnol, 18, 3, 313-316 , 18, 3, 313-316 2000 公開
Song-Induced Phosphorylation of cAMP Response Element Binding Protein in the Songbird Brain Song-Induced Phosphorylation of cAMP Response Element Binding Protein in the Songbird Brain J.Neuroscience, 19, 3973-3981 J.Neuroscience, 19, 3973-3981 , 19, 3973-3981 1999 公開
KOIZUMI J, OKAMOTO Y, ONOGI H, MAYEDA A, KRAINER A R, HAGIWARA M KOIZUMI J, OKAMOTO Y, ONOGI H, MAYEDA A, KRAINER A R, HAGIWARA M The subcellular localization of SF2/ASF is regulated by the direct interaction with SR protein kinases (SRPKs) The subcellular localization of SF2/ASF is regulated by the direct interaction with SR protein kinases (SRPKs) J. Biol. Chem., 274, 16, 11125-11131 J. Biol. Chem., 274, 16, 11125-11131 , 274, 16, 11125-11131 1999 公開
Characterization of a Serum Response Factor-Like Protein in Saccharomyces cerevisiae, Rlml, Which Has Transcriptional Activity Regulated by the Mpli(Slt2)Mitogen-Activated Protein Kinase Pathway Characterization of a Serum Response Factor-Like Protein in Saccharomyces cerevisiae, Rlml, Which Has Transcriptional Activity Regulated by the Mpli(Slt2)Mitogen-Activated Protein Kinase Pathway Mol. Cell. Biol., 17, 5, 2615-2623 Mol. Cell. Biol., 17, 5, 2615-2623 , 17, 5, 2615-2623 1997 公開
CHRIVIA J C, KWOK R P S, LAMB N, HAGIWARA M, MONTMINY M R, GOODMAN R H CHRIVIA J C, KWOK R P S, LAMB N, HAGIWARA M, MONTMINY M R, GOODMAN R H Phosphorylated CREB binds specifically to the nuclear protein CBP Phosphorylated CREB binds specifically to the nuclear protein CBP Nature, 365, 6449, 855-859 Nature, 365, 6449, 855-859 , 365, 6449, 855-859 1993 公開
Stimulus-transcripution coupling through the cAMP responsive factor CREB is rate-limited by the nuclear entry of PK-A Stimulus-transcripution coupling through the cAMP responsive factor CREB is rate-limited by the nuclear entry of PK-A Molecular and Cellular Biology, 13, 4852-4859 Molecular and Cellular Biology, 13, 4852-4859 , 13, 4852-4859 1993 公開
HAGIWARA M, ALBERTS A, BRINDLE P, MEINKOTH J, FERAMISCO J, DENG T, KARIN M, SHENOLIKAR S, MONTMINY M HAGIWARA M, ALBERTS A, BRINDLE P, MEINKOTH J, FERAMISCO J, DENG T, KARIN M, SHENOLIKAR S, MONTMINY M Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB Cell, 70, 1, 105-113 Cell, 70, 1, 105-113 , 70, 1, 105-113 1992 公開
Novel SR-related Clasp protein specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk Novel SR-related Clasp protein specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk J. Boil. Chem, 277, 46, 44220-44228 , 277, 46, 44220-44228 J. Boil. Chem, 277, 46, 44220-44228 2002 公開
A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elogans A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elogans EMBO Rep, 3, 962-966 , 3, 962-966 EMBO Rep, 3, 962-966 2002 公開
A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo. A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo. Nat. Biotechnol, 18, 3, 313-316 , 18, 3, 313-316 Nat. Biotechnol, 18, 3, 313-316 2000 公開
SPK-1 a C. elegans SR proteins kinase homologue, is essential for embryogenesis and required for germline development. SPK-1 a C. elegans SR proteins kinase homologue, is essential for embryogenesis and required for germline development. Mech. Dev., in press , in press Mech. Dev., in press 2000 公開
Spectrum of autoantibodies against a dynamin-related protein, dymple. Spectrum of autoantibodies against a dynamin-related protein, dymple. Arthritis & Rheumatism., 43, 7, 1516-1519 , 43, 7, 1516-1519 Arthritis & Rheumatism., 43, 7, 1516-1519 2000 公開
Novel RING finger proteins, Air1p and 2p interact with Hmt1p and inhibit the arginine methylation of Np13p. Novel RING finger proteins, Air1p and 2p interact with Hmt1p and inhibit the arginine methylation of Np13p. J.Biol. Chem., in press , in press J.Biol. Chem., in press 2000 公開
Direct imaging of phosphorylation dependent congormational change and DNA binding of CREB by electron microscopy. Direct imaging of phosphorylation dependent congormational change and DNA binding of CREB by electron microscopy. Genes to Cells., 5, 6, 515-522 , 5, 6, 515-522 Genes to Cells., 5, 6, 515-522 2000 公開
Song-Induced Phosphorylation of cAMP Response Element Binding Protein in the Songbird Brain. Song-Induced Phosphorylation of cAMP Response Element Binding Protein in the Songbird Brain. J.Neuroscience, 19, 3973-3981 , 19, 3973-3981 J.Neuroscience, 19, 3973-3981 1999 公開
The subcellular localization of SF2/ASF is regulated by the direct interaction with SR protein kinases (SRPKs). The subcellular localization of SF2/ASF is regulated by the direct interaction with SR protein kinases (SRPKs). J. Biol. Chem., 274, 16, 11125-11131 , 274, 16, 11125-11131 J. Biol. Chem., 274, 16, 11125-11131 1999 公開
Dymple, a Novel Dynamin-like High Molecular Weight GTPase Lacking a Proline-rich Carboxyl-terminal Domain in Mammalian Cells. Dymple, a Novel Dynamin-like High Molecular Weight GTPase Lacking a Proline-rich Carboxyl-terminal Domain in Mammalian Cells. J.Biol. Chem., 273, 2, 1044-1051 , 273, 2, 1044-1051 J.Biol. Chem., 273, 2, 1044-1051 1998 公開
Dominant Negative ATF1 Blocks Cyclic AMP-Induced Neurite Outgrowth in PC12D Cells. Dominant Negative ATF1 Blocks Cyclic AMP-Induced Neurite Outgrowth in PC12D Cells. J.Neurochem., 70, 1029-1034 , 70, 1029-1034 J.Neurochem., 70, 1029-1034 1998 公開
Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. Biochem. Biophys. Res. Commun., 242, 2, 357-364 , 242, 2, 357-364 Biochem. Biophys. Res. Commun., 242, 2, 357-364 1998 公開
Characterization of a Serum Response Factor-Like Protein in Saccharomyces cerevisiae, Rlml, Which Has Transcriptional Activity Regulated by the Mpli(Slt2)Mitogen-Activated Protein Kinase Pathway. Characterization of a Serum Response Factor-Like Protein in Saccharomyces cerevisiae, Rlml, Which Has Transcriptional Activity Regulated by the Mpli(Slt2)Mitogen-Activated Protein Kinase Pathway. Mol. Cell. Biol., 17, 5, 2615-2623 , 17, 5, 2615-2623 Mol. Cell. Biol., 17, 5, 2615-2623 1997 公開
Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na, K-ATPase al subunit gene promotor. Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na, K-ATPase al subunit gene promotor. Nucleic Acid Research., 25, 4, 877-882 , 25, 4, 877-882 Nucleic Acid Research., 25, 4, 877-882 1997 公開
A novel kinase cascade mediated by MAPKK6 and MKK3. A novel kinase cascade mediated by MAPKK6 and MKK3. J. Biol. Chem., 271, 13675-13679 , 271, 13675-13679 J. Biol. Chem., 271, 13675-13679 1996 公開
Calmodulin-dependent protein kinase II potentiates transcriptional activation through ATF1, but not CREB. Calmodulin-dependent protein kinase II potentiates transcriptional activation through ATF1, but not CREB. J. Biol. Chem., 271, 30, 17957-17960 , 271, 30, 17957-17960 J. Biol. Chem., 271, 30, 17957-17960 1996 公開
Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of MAPKK6 by osmotic shock, tumor Necrosis factor-a and H202. Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of MAPKK6 by osmotic shock, tumor Necrosis factor-a and H202. J. Biol. Chem., 271, 17957-17960 , 271, 17957-17960 J. Biol. Chem., 271, 17957-17960 1996 公開
Gene therapy against an experimental glioma using adeno-associated virus vectors. Gene therapy against an experimental glioma using adeno-associated virus vectors. Gene Therapy, 3, 957-964 , 3, 957-964 Gene Therapy, 3, 957-964 1996 公開
Light-induced CREB phosphorylation and gene expression in rat retinal cells. Light-induced CREB phosphorylation and gene expression in rat retinal cells. J. Neurochem., 65, 1499-1504 , 65, 1499-1504 J. Neurochem., 65, 1499-1504 1995 公開
Recombinant cyclic AMP response element binding protein(CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei. Recombinant cyclic AMP response element binding protein(CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei. J. Biol. Chem., 269, 7623-30 , 269, 7623-30 J. Biol. Chem., 269, 7623-30 1994 公開
Phosphorylated CREB binds specifically to the nuclear protein CBP. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature, 365, 6449, 855-859 , 365, 6449, 855-859 Nature, 365, 6449, 855-859 1993 公開
Stimulus-transcripution coupling through the cAMP responsive factor CREB is rate-limited by the nuclear entry of PK-A. Stimulus-transcripution coupling through the cAMP responsive factor CREB is rate-limited by the nuclear entry of PK-A. Molecular and Cellular Biology, 13, 4852-4859 , 13, 4852-4859 Molecular and Cellular Biology, 13, 4852-4859 1993 公開
Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell, 70, 1, 105-113 , 70, 1, 105-113 Cell, 70, 1, 105-113 1992 公開
Accelerated proliferation and interleukin-2 production of thymocytes by stimulation of soluble anti-CD3 monoclonal antibody in transgenic mice carrying a rabbit protein kinase C alpha. Accelerated proliferation and interleukin-2 production of thymocytes by stimulation of soluble anti-CD3 monoclonal antibody in transgenic mice carrying a rabbit protein kinase C alpha. J. Biol. Chem., 267, 18644-8 , 267, 18644-8 J. Biol. Chem., 267, 18644-8 1992 公開
Identification of a 80 kDa calmodulin-binding protein as a new Ca2+/calmodulin-dependent kinase by renaturation blotting assay(RBA). Identification of a 80 kDa calmodulin-binding protein as a new Ca2+/calmodulin-dependent kinase by renaturation blotting assay(RBA). Biochem. J., 281, 339-42 , 281, 339-42 Biochem. J., 281, 339-42 1992 公開
Overcoming of vinblastine resistance by isoquinolinesulfonamide compounds in adriamycin-resistant leukemia cells. Overcoming of vinblastine resistance by isoquinolinesulfonamide compounds in adriamycin-resistant leukemia cells. Mol. Pharmacol., 41, 1034-1038 , 41, 1034-1038 Mol. Pharmacol., 41, 1034-1038 1992 公開

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外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
平成22年度、日本学術振興会 基盤研究(A) 代表 スプライシング暗号の解読による神経発生過程の解明
平成22年度、 厚生労働科学研究費補助金 肝炎等克服緊急対策研究事業 分担 肝炎ウイルス感染複製増殖過程の解明と新規治療法開発に関する研究
平成21年度、厚労科研費補助金 難治性疾患克服研究事業  代表 「未熟児網膜症の原因と治療に関する調査研究」
平成21年度、日本学術振興会 基盤研究(A) 代表 スプライシング暗号の解読による神経発生過程の解明
平成20年度、文部科学省 特定領域研究 代表 「ヘルペスウイルスRNAの核外輸送制御機構の解明」
平成20年度、日本学術振興会 基盤(B) 代表 「イントロレンスRNAの核外輸送の分子メカニズム」
平成20年度、日本学術振興会 基盤(C)+D5006 分担 「中枢神経系におけるプロテオームの多様化創出と部位特異的発現制御メカニズムの解明
基盤研究(A) 代表 タウ蛋白不安定化剤による新しいタウオパチー治療戦略の構築 2012〜2014
基盤研究(A) 代表 タウ蛋白不安定化剤による新しいタウオパチー治療戦略の構築 2012/04/01〜2015/03/31
基盤研究(A) 代表 タウ蛋白不安定化剤による新しいタウオパチー治療戦略の構築 (平成26年度分) 2014/04/01〜2015/03/31
基盤研究(S) 代表 CRISPRによるRNA病モデルiPS細胞・動物の構築と病態解明・治療薬創製 (平成27年度分) 2015/04/01〜2016/03/31
基盤研究(A) 代表 トランスクリプトームの人為的操作による遺伝病の治療 (平成27年度分) 2015/04/01〜2016/03/31
基盤研究(S) 代表 CRISPRによるRNA病モデルiPS細胞・動物の構築と病態解明・治療薬創製 (平成28年度分) 2016/04/01〜2017/03/31
基盤研究(S) 代表 CRISPRによるRNA病モデルiPS細胞・動物の構築と病態解明・治療薬創製 (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(S) 代表 CRISPRによるRNA病モデルiPS細胞・動物の構築と病態解明・治療薬創製 (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(S) 代表 CRISPRによるRNA病モデルiPS細胞・動物の構築と病態解明・治療薬創製 (平成30年度分) 2018/04/01〜2019/03/31

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外部資金:競争的資金・科学研究費補助金以外
制度名 代表者名 研究課題(日本語) 研究課題(英語) 期間
文部科学省 創薬等ライフサイエンス研究支援基盤事業 萩原 正敏 「大型創薬研究基盤を活用した創薬オープンイノベーションの推進」(細胞アッセイから治験までのワンストップ創薬支援) 2012〜2016
文部科学省 創薬等ライフサイエンス研究支援基盤事業 萩原 正敏 「大型創薬研究基盤を活用した創薬オープンイノベーションの推進」(細胞アッセイから治験までのワンストップ創薬支援) (平成26年度分) 2014/04/01〜2015/03/31
文部科学省 医療研究開発推進事業費補助金 萩原 正敏 「大型創薬研究基盤を活用した創薬オープンイノベーションの推進」(細胞アッセイから治験までのワンストップ創薬支援) (平成27年度分) 2015/04/01〜2016/03/31
厚生労働省 医薬品等審査迅速化事業費補助金 萩原 正敏 医薬品分野(アルツハイマー病、非臨床評価、薬剤疫学) (平成27年度分) 2015/04/01〜2016/03/31
医療研究開発推進事業費補助金 萩原 正敏 「大型創薬研究基盤を活用した創薬オープンイノベーションの推進」(細胞アッセイから治験までのワンストップ創薬支援) (平成28年度分) 2016/04/01〜2017/03/31
医薬品等審査迅速化事業費補助金 萩原 正敏  医薬品分野(アルツハイマー病、非臨床評価、薬剤疫学) (平成28年度分) 2016/04/01〜2017/03/31
医療研究開発推進事業費補助金 萩原 正敏 臨床研究につなぐワンストップ創薬支援 (平成29年度分) 2017/04/01〜2018/03/31
医療研究開発推進事業費補助金 萩原 正敏 臨床研究につなぐワンストップ創薬支援 (平成30年度分) 2018/04/01〜2019/03/31
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
医科学研究 前期不定 医学研究科 2011/04〜2012/03
A2 肉眼解剖学講義実習 Human Gross Anatomy and its Laboratory Course 前期 医学部 2013/04〜2014/03
医学概論 Introduction to medical science 通年 全学共通科目 2013/04〜2014/03
体験的医学研究入門 Hands-on medical research experience 前期集中 全学共通科目 2013/04〜2014/03
A2 肉眼解剖学講義実習 Human Gross Anatomy and its Laboratory Course 前期 医学部 2014/04〜2015/03
医学研究技術実習 Practicum on Medical Research 通年不定 医学研究科 2014/04〜2015/03
人体解剖学(LIMS) Human Anatomy 前期集中 医学研究科 2014/04〜2015/03
人体解剖学 Human Anatomy 前期 工学研究科 2014/04〜2015/03
人体構造学 Human Anatomy 前期 総合生存学館 2014/04〜2015/03
医学概論 Introduction to medical science 通年 全学共通科目 2014/04〜2015/03
体験的医学研究入門 Hands-on medical research experience 前期集中 全学共通科目 2014/04〜2015/03
A2 肉眼解剖学講義実習 Human Gross Anatomy and its Laboratory Course 前期 医学部 2015/04〜2016/03
人体構造学 Human Anatomy 前期 総合生存学館 2015/04〜2016/03
人体解剖学 Human Anatomy 前期 工学研究科 2015/04〜2016/03
人体解剖学(LIMS) Human Anatomy 前期集中 医学研究科 2015/04〜2016/03
医学概論 Introduction to medical science 通年 全学共通科目 2015/04〜2016/03
医学研究技術実習 Practicum on Medical Research 通年不定 医学研究科 2015/04〜2016/03
A2 肉眼解剖学講義実習 Human Gross Anatomy and its Laboratory Course 前期 医学部 2016/04〜2017/03
人体構造学 Human Anatomy 前期 総合生存学館 2016/04〜2017/03
人体解剖学 Human Anatomy 前期 工学研究科 2016/04〜2017/03
人体解剖学(LIMS) Human Anatomy 前期集中 医学研究科 2016/04〜2017/03
医学研究技術実習 Practicum on Medical Research 通年不定 医学研究科 2016/04〜2017/03
A2 肉眼解剖学講義実習 Human Gross Anatomy and its Laboratory Course 前期 医学部 2017/04〜2018/03
B1 肉眼解剖学 Human Gross Anatomy and its Laboratory Course 前期 医学部 2017/04〜2018/03
人体解剖学 Human Anatomy 前期 工学研究科 2017/04〜2018/03
人体解剖学(LIMS) Human Anatomy (LIMS) 前期集中 医学研究科 2017/04〜2018/03
医学研究技術実習 Practicum on Medical Research 通年不定 医学研究科 2017/04〜2018/03
A2 肉眼解剖学講義実習 Human Gross Anatomy and its Laboratory Course 前期 医学部 2018/04〜2019/03
B1 肉眼解剖学 Human Gross Anatomy and its Laboratory Course 前期 医学部 2018/04〜2019/03
人体解剖学 Human Anatomy 前期 工学研究科 2018/04〜2019/03
人体解剖学(LIMS) Human Anatomy (LIMS) 前期集中 医学研究科 2018/04〜2019/03
医学研究技術実習 Practicum on Medical Research 通年不定 医学研究科 2018/04〜2019/03
A2 肉眼解剖学講義実習 Human Gross Anatomy and its Laboratory Course 前期 医学部 2019/04〜2020/03
B1 肉眼解剖学 Human Gross Anatomy and its Laboratory Course 前期 医学部 2019/04〜2020/03
人体解剖学(LIMS) Human Anatomy (LIMS) 前期集中 医学研究科 2019/04〜2020/03
医学研究技術実習 Practicum on Medical Research 通年不定 医学研究科 2019/04〜2020/03

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全学運営(役職等)
役職名 期間
設備整備ワーキンググループ委員会 2012/04/01〜2014/03/31
設備整備ワーキンググループ 委員 2012/04/01〜2014/09/30
先天異常標本解析センター長 2013/01/31〜2017/01/30
総合解剖センター長 2013/01/31〜2017/01/30
設備整備ワーキンググループ 座長 2014/10/01〜2016/09/30
財務委員会 委員 2014/10/01〜2016/09/30
総合技術部委員会 委員 2016/01/14〜2016/09/30
医・薬学域長 2016/04/01〜2018/03/31
基礎・社会医学系長 2016/04/01〜2018/03/31
評価に応じた予算配分に係る制度検討ワーキンググループ 委員 2016/04/01〜2016/09/30
指定国立大学法人制度検討ワーキンググループ委員 2016/07/12〜
指定国立大学法人制度検討タスクフォース 委員 2016/09/30〜2017/03/31
総合技術部委員会 委員 2016/01/14〜2018/09/30
運営協議員 2016/04/01〜2018/03/31
医・薬学域長 2016/04/01〜2020/03/31
基礎・社会医学系長 2016/04/01〜2020/03/31
理事補 2017/11/01〜2018/09/30
京都大学(南部)総合研究棟(医薬系)施設整備事業提案審査委員会の設置に伴う委員 2013/10/01〜
理事補 2017/11/01〜2020/09/30
企画委員会On-site Laboratory認定専門委員会 副委員長 2018/07/24〜2020/09/30
戦略調整会議 委員 2018/10/01〜2020/09/30
戦略調整会議On-site Laboratory小委員会 委員長 2018/10/01〜2020/09/30
戦略調整会議留学生リクルーティングオフィス小委員会 委員 2018/06/05〜2020/09/30
戦略調整会議授業料設定の柔軟化検討小委員会 委員長 2018/10/22〜2020/09/30
国際教育委員会国際学生交流委員会アムジェン・スカラーズ・プログラム小委員会 委員 2019/01/01〜2019/12/31
教育研究評議会 評議員 2018/10/01〜2021/03/31
高等研究院運営協議員委員 2018/04/01〜2020/03/31
産官学連携本部運営会議 2019/04/01〜2020/03/31

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部局運営(役職等)
役職名 期間
解剖・先天異常標本解析センター委員会、委員
学位審査選定委員会、委員
利益相反予備審査委員会 2011/01/27〜
副研究科長 2013/10/01〜2018/09/30
医学広報委員会 2017/10/01〜2018/09/30
医学研究科・医学部人権委員会
医学研究科・医学部将来計画検討委員会 2013/10/01〜2018/09/30
医学研究科運営委員会 〜2014/03/31
医学部学務委員会 2012/05/10〜2016/03/31
医科学専攻長 2013/10/01〜2018/09/30
寄附講座運営委員会(免疫ゲノム医学) 2013/04/01〜2015/03/31
バイオ・フロンティア・プラットフォーム運営委員会 2012/01/26〜
附属ゲノム医学センター運営委員会 2013/04/01〜
医学研究支援センター運営委員会
寄附講座運営委員会(免疫ゲノム医学) 2016/04/01〜2020/03/31
寄附講座運営委員会(創薬医学) 2016/04/01〜2020/03/31
管理体制委員会 2017/10/01〜2020/09/30
脳機能総合研究センター運営委員会 2017/08/01〜2019/07/31
医学部資料館運営委員会
教員人事活性化委員会 2015/09/24〜
「医学領域」産学連携推進機構会議 2015/04/01〜
京都大学医薬系総合研究棟管理運営委員会 委員 2016/10/01〜2020/09/30
京都大学分子生物実験研究棟管理運営委員会 委員 2016/12/01〜2018/11/30
医学研究科・医学部財務委員会
評議員(附属病院) 2019/04/01〜2021/03/31
将来計画検討委員会 2019/04/01〜2021/03/31

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その他活動:国・地方公共団体での活動
委員会名(日本語) 委員会名(英語) 役職名 公共団体の名称 期間
文部科学省 最先端研究基盤事業「化合物ライブラリーを活用した創薬等最先端研究・教育基盤の整備の選定」に関わる検討委員