萩原 正敏

最終更新日時: 2020/10/20 14:09:46

印刷する

氏名(漢字/フリガナ/アルファベット表記)
萩原 正敏/ハギワラ マサトシ/Hagiwara, Masatoshi
所属部署・職名(部局/所属/講座等/職名)
医学研究科/医学専攻生体構造医学講座形態形成機構学/教授
学部兼担
部局 所属 講座等 職名
医学部
連絡先住所
種別 住所(日本語) 住所(英語)
職場 京都市左京区吉田近衛町 Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
連絡先電話番号
種別 番号
職場 075-753-4341
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
医学博士 三重大学
職歴
期間 組織名(日本語) 組織名(英語) 職名(日本語) 職名(英語)
researchmap URL
https://researchmap.jp/read0011076
研究テーマ
(日本語)
mRNAスプライシング制御機構の解明、遺伝病治療薬の開発、抗ウイルス薬の創薬研究
(英語)
RNA Splicing, Genetic Diseases, Drug Discovery
研究概要
(日本語)
人類は7,000以上の遺伝病に罹患し約35%が異常なRNAスプライシングを伴う。薬剤でRNAのスプライシングパターンを変化させることにより先天性の難病を治すことは可能ではないかと考え、RNAスプライシング制御機構の解明に向けて研究を展開してきた。家族性自律神経失調症という遺伝病はIKBKAP遺伝子のエクソン20のスプライス異常に起因するため、変異型IKBKAP遺伝子を組み込んだスプライシングレポーターを使って化合物スクリーニングを行い、異常スプライシングを正常化させる治療薬候補物質RECTASを見出した。またデュシェンネ型筋ジストロフィー患者の筋芽細胞に、自ら開発したスプライシング制御化合物TG003を投与することによって、筋肉の維持に必要なジストロフィン蛋白質の発現を回復させることもできた。スプライシング操作薬によって、特定の変異を有する患者に対する精密治療が可能で、心ファブリ病、嚢胞性線維症、QT延長症候群などの患者細胞で有効性が確認された。また上記の研究途上に、種々のウイルスRNA合成を特異的に阻害する画期的な抗ウイルス薬FIT-039を見出し、疣贅や子宮頚癌に対する医師主導第1/2相臨床試験が進行中で、新型コロナウイルスへの効果も検討されている。
(英語)
He succeeded to visualize tissue-specific and developmental-stage-specific alternative splicing patterns in living nematode worms, and identified the regulatory factors by genomic mapping of the mutants (Nat Methods 2006, Nat Protocols 2010). He further developed the splicing reporter technology, established a dual-color splicing reporter screening system called SPREADD (splicing reporter assay for disease genes with dual-color), applied this to aberrant splicing of IKBKAP exon 20 found in FD patients due to the intronic mutation (IVS20+6T>C), and identified a compound RECTAS that efficiently corrects the mis-splicing of IKBKAP (PNAS 2015). He also developed an anti-virus drug FIT039 targeting host factors required for virus proliferation. FIT039 specifically inhibits CDK9 and suppresses viral transcription of a broad spectrum of DNA viruses including HCMV, HAdV, HBV and HPV without significant adverse effect on mammalian cells (J Clin Invest. 2014, Clin Cancer Res. 2018). The phase1/2a clinical trial of FIT039 for cervical intraepithelial neoplasia (CIN) is under the way in Kyoto University Hospital.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
ケミカルバイオロジー Chemical Biology
RNA RNA Biology
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Akihide Takeuchi, Yuji Takahashi, Kei Iida, Motoyasu Hosokawa, Koichiro Irie, Mikako Ito, J B Brown, Kinji Ohno, Kinichi Nakashima, Masatoshi Hagiwara Akihide Takeuchi, Yuji Takahashi, Kei Iida, Motoyasu Hosokawa, Koichiro Irie, Mikako Ito, J B Brown, Kinji Ohno, Kinichi Nakashima, Masatoshi Hagiwara Akihide Takeuchi, Yuji Takahashi, Kei Iida, Motoyasu Hosokawa, Koichiro Irie, Mikako Ito, J B Brown, Kinji Ohno, Kinichi Nakashima, Masatoshi Hagiwara Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage. Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage. Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage. Stem cell reports, 15, 4, 883-897 Stem cell reports, 15, 4, 883-897 Stem cell reports, 15, 4, 883-897 2020/10/13 英語 研究論文(学術雑誌) 公開
Saiko Shibata, Masahiko Ajiro, Masatoshi Hagiwara Saiko Shibata, Masahiko Ajiro, Masatoshi Hagiwara Saiko Shibata, Masahiko Ajiro, Masatoshi Hagiwara Mechanism-Based Personalized Medicine for Cystic Fibrosis by Suppressing Pseudo Exon Inclusion. Mechanism-Based Personalized Medicine for Cystic Fibrosis by Suppressing Pseudo Exon Inclusion. Mechanism-Based Personalized Medicine for Cystic Fibrosis by Suppressing Pseudo Exon Inclusion. Cell chemical biology Cell chemical biology Cell chemical biology 2020/09/07 英語 研究論文(学術雑誌) 公開
Ryo Kimura, Roy Lardenoije, Kiyotaka Tomiwa, Yasuko Funabiki, Masatoshi Nakata, Shiho Suzuki, Tomonari Awaya, Takeo Kato, Shin Okazaki, Toshiya Murai, Toshio Heike, Bart P F Rutten, Masatoshi Hagiwara Ryo Kimura, Roy Lardenoije, Kiyotaka Tomiwa, Yasuko Funabiki, Masatoshi Nakata, Shiho Suzuki, Tomonari Awaya, Takeo Kato, Shin Okazaki, Toshiya Murai, Toshio Heike, Bart P F Rutten, Masatoshi Hagiwara Ryo Kimura, Roy Lardenoije, Kiyotaka Tomiwa, Yasuko Funabiki, Masatoshi Nakata, Shiho Suzuki, Tomonari Awaya, Takeo Kato, Shin Okazaki, Toshiya Murai, Toshio Heike, Bart P F Rutten, Masatoshi Hagiwara Integrated DNA methylation analysis reveals a potential role for ANKRD30B in Williams syndrome. Integrated DNA methylation analysis reveals a potential role for ANKRD30B in Williams syndrome. Integrated DNA methylation analysis reveals a potential role for ANKRD30B in Williams syndrome. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 45, 10, 1627-1636 Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 45, 10, 1627-1636 Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 45, 10, 1627-1636 2020/09 英語 研究論文(学術雑誌) 公開
Kei Iida, Masatoshi Hagiwara, Akihide Takeuchi Kei Iida, Masatoshi Hagiwara, Akihide Takeuchi Kei Iida, Masatoshi Hagiwara, Akihide Takeuchi Multilateral Bioinformatics Analyses Reveal the Function-Oriented Target Specificities and Recognition of the RNA-Binding Protein SFPQ. Multilateral Bioinformatics Analyses Reveal the Function-Oriented Target Specificities and Recognition of the RNA-Binding Protein SFPQ. Multilateral Bioinformatics Analyses Reveal the Function-Oriented Target Specificities and Recognition of the RNA-Binding Protein SFPQ. iScience, 23, 7, 101325-101325 iScience, 23, 7, 101325-101325 iScience, 23, 7, 101325-101325 2020/07/24 英語 研究論文(学術雑誌) 公開
Shiho Suzuki, Ryo Kimura, Shingo Maegawa, Masatoshi Nakata, Masatoshi Hagiwara Shiho Suzuki, Ryo Kimura, Shingo Maegawa, Masatoshi Nakata, Masatoshi Hagiwara Shiho Suzuki, Ryo Kimura, Shingo Maegawa, Masatoshi Nakata, Masatoshi Hagiwara Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish. Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish. Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish. Molecular brain, 13, 1, 70-70 Molecular brain, 13, 1, 70-70 Molecular brain, 13, 1, 70-70 2020/05/06 英語 研究論文(学術雑誌) 公開
Ryo Kimura, Kiyotaka Tomiwa, Ryo Inoue, Shiho Suzuki, Masatoshi Nakata, Tomonari Awaya, Takeo Kato, Shin Okazaki, Toshio Heike, Masatoshi Hagiwara Ryo Kimura, Kiyotaka Tomiwa, Ryo Inoue, Shiho Suzuki, Masatoshi Nakata, Tomonari Awaya, Takeo Kato, Shin Okazaki, Toshio Heike, Masatoshi Hagiwara Ryo Kimura, Kiyotaka Tomiwa, Ryo Inoue, Shiho Suzuki, Masatoshi Nakata, Tomonari Awaya, Takeo Kato, Shin Okazaki, Toshio Heike, Masatoshi Hagiwara Dysregulation of the oxytocin receptor gene in Williams syndrome. Dysregulation of the oxytocin receptor gene in Williams syndrome. Dysregulation of the oxytocin receptor gene in Williams syndrome. Psychoneuroendocrinology, 115, 104631-104631 Psychoneuroendocrinology, 115, 104631-104631 Psychoneuroendocrinology, 115, 104631-104631 2020/05 英語 研究論文(学術雑誌) 公開
Masahiro Kawashima, Mariko Tokiwa, Tomomi Nishimura, Yukiko Kawata, Masahiro Sugimoto, Tatsuki R Kataoka, Takaki Sakurai, Keiko Iwaisako, Eiji Suzuki, Masatoshi Hagiwara, Adrian L Harris, Masakazu Toi Masahiro Kawashima, Mariko Tokiwa, Tomomi Nishimura, Yukiko Kawata, Masahiro Sugimoto, Tatsuki R Kataoka, Takaki Sakurai, Keiko Iwaisako, Eiji Suzuki, Masatoshi Hagiwara, Adrian L Harris, Masakazu Toi Masahiro Kawashima, Mariko Tokiwa, Tomomi Nishimura, Yukiko Kawata, Masahiro Sugimoto, Tatsuki R Kataoka, Takaki Sakurai, Keiko Iwaisako, Eiji Suzuki, Masatoshi Hagiwara, Adrian L Harris, Masakazu Toi High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer. High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer. High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer. British journal of cancer, 122, 2, 245-257 British journal of cancer, 122, 2, 245-257 British journal of cancer, 122, 2, 245-257 2020/01 英語 研究論文(学術雑誌) 公開
Masatoshi Nakata, Ryo Kimura, Yasuko Funabiki, Tomonari Awaya, Toshiya Murai, Masatoshi Hagiwara Masatoshi Nakata, Ryo Kimura, Yasuko Funabiki, Tomonari Awaya, Toshiya Murai, Masatoshi Hagiwara Masatoshi Nakata, Ryo Kimura, Yasuko Funabiki, Tomonari Awaya, Toshiya Murai, Masatoshi Hagiwara MicroRNA profiling in adults with high-functioning autism spectrum disorder. MicroRNA profiling in adults with high-functioning autism spectrum disorder. MicroRNA profiling in adults with high-functioning autism spectrum disorder. Molecular brain, 12, 1, 82-82 Molecular brain, 12, 1, 82-82 Molecular brain, 12, 1, 82-82 2019/10/21 英語 研究論文(学術雑誌) 公開
Ryo Kimura, Masatoshi Nakata, Yasuko Funabiki, Shiho Suzuki, Tomonari Awaya, Toshiya Murai, Masatoshi Hagiwara Ryo Kimura, Masatoshi Nakata, Yasuko Funabiki, Shiho Suzuki, Tomonari Awaya, Toshiya Murai, Masatoshi Hagiwara Ryo Kimura, Masatoshi Nakata, Yasuko Funabiki, Shiho Suzuki, Tomonari Awaya, Toshiya Murai, Masatoshi Hagiwara An epigenetic biomarker for adult high-functioning autism spectrum disorder. An epigenetic biomarker for adult high-functioning autism spectrum disorder. An epigenetic biomarker for adult high-functioning autism spectrum disorder. Scientific reports, 9, 1, 13662-13662 Scientific reports, 9, 1, 13662-13662 Scientific reports, 9, 1, 13662-13662 2019/09/20 英語 研究論文(学術雑誌) 公開
Takashi Nomura, Eriko Sumi, Gyohei Egawa, Saeko Nakajima, Eiko Toichi, Ryuji Uozumi, Harue Tada, Takayuki Nakagawa, Masatoshi Hagiwara, Kenji Kabashima Takashi Nomura, Eriko Sumi, Gyohei Egawa, Saeko Nakajima, Eiko Toichi, Ryuji Uozumi, Harue Tada, Takayuki Nakagawa, Masatoshi Hagiwara, Kenji Kabashima Takashi Nomura, Eriko Sumi, Gyohei Egawa, Saeko Nakajima, Eiko Toichi, Ryuji Uozumi, Harue Tada, Takayuki Nakagawa, Masatoshi Hagiwara, Kenji Kabashima The efficacy of a cyclin dependent kinase 9 (CDK9) inhibitor, FIT039, on verruca vulgaris: study protocol for a randomized controlled trial. The efficacy of a cyclin dependent kinase 9 (CDK9) inhibitor, FIT039, on verruca vulgaris: study protocol for a randomized controlled trial. The efficacy of a cyclin dependent kinase 9 (CDK9) inhibitor, FIT039, on verruca vulgaris: study protocol for a randomized controlled trial. Trials, 20, 1, 489-489 Trials, 20, 1, 489-489 Trials, 20, 1, 489-489 2019/08/09 英語 研究論文(学術雑誌) 公開
Yohei Korogi, Shimpei Gotoh, Satoshi Ikeo, Yuki Yamamoto, Naoyuki Sone, Koji Tamai, Satoshi Konishi, Tadao Nagasaki, Hisako Matsumoto, Isao Ito, Toyofumi F Chen-Yoshikawa, Hiroshi Date, Masatoshi Hagiwara, Isao Asaka, Akitsu Hotta, Michiaki Mishima, Toyohiro Hirai Yohei Korogi, Shimpei Gotoh, Satoshi Ikeo, Yuki Yamamoto, Naoyuki Sone, Koji Tamai, Satoshi Konishi, Tadao Nagasaki, Hisako Matsumoto, Isao Ito, Toyofumi F Chen-Yoshikawa, Hiroshi Date, Masatoshi Hagiwara, Isao Asaka, Akitsu Hotta, Michiaki Mishima, Toyohiro Hirai Yohei Korogi, Shimpei Gotoh, Satoshi Ikeo, Yuki Yamamoto, Naoyuki Sone, Koji Tamai, Satoshi Konishi, Tadao Nagasaki, Hisako Matsumoto, Isao Ito, Toyofumi F Chen-Yoshikawa, Hiroshi Date, Masatoshi Hagiwara, Isao Asaka, Akitsu Hotta, Michiaki Mishima, Toyohiro Hirai In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids. In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids. In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids. Stem cell reports, 13, 1, 235-235 Stem cell reports, 13, 1, 235-235 Stem cell reports, 13, 1, 235-235 2019/07/09 英語 公開
Ryo Kimura, Vivek Swarup, Kiyotaka Tomiwa, Michael J. Gandal, Neelroop N. Parikshak, Yasuko Funabiki, Masatoshi Nakata, Tomonari Awaya, Takeo Kato, Kei Iida, Shin Okazaki, Kanae Matsushima, Toshihiro Kato, Toshiya Murai, Toshio Heike, Daniel H. Geschwind, Masatoshi Hagiwara Ryo Kimura, Vivek Swarup, Kiyotaka Tomiwa, Michael J. Gandal, Neelroop N. Parikshak, Yasuko Funabiki, Masatoshi Nakata, Tomonari Awaya, Takeo Kato, Kei Iida, Shin Okazaki, Kanae Matsushima, Toshihiro Kato, Toshiya Murai, Toshio Heike, Daniel H. Geschwind, Masatoshi Hagiwara Ryo Kimura, Vivek Swarup, Kiyotaka Tomiwa, Michael J. Gandal, Neelroop N. Parikshak, Yasuko Funabiki, Masatoshi Nakata, Tomonari Awaya, Takeo Kato, Kei Iida, Shin Okazaki, Kanae Matsushima, Toshihiro Kato, Toshiya Murai, Toshio Heike, Daniel H. Geschwind, Masatoshi Hagiwara Integrative network analysis reveals biological pathways associated with Williams syndrome Integrative network analysis reveals biological pathways associated with Williams syndrome Integrative network analysis reveals biological pathways associated with Williams syndrome Journal of Child Psychology and Psychiatry, 60, 5, 585-598 Journal of Child Psychology and Psychiatry, 60, 5, 585-598 Journal of Child Psychology and Psychiatry, 60, 5, 585-598 2019/05 研究論文(学術雑誌) 公開
Jose Ichisima, Naoya M Suzuki, Bumpei Samata, Tomonari Awaya, Jun Takahashi, Masatoshi Hagiwara, Tatsutoshi Nakahata, Megumu K Saito Jose Ichisima, Naoya M Suzuki, Bumpei Samata, Tomonari Awaya, Jun Takahashi, Masatoshi Hagiwara, Tatsutoshi Nakahata, Megumu K Saito Jose Ichisima, Naoya M Suzuki, Bumpei Samata, Tomonari Awaya, Jun Takahashi, Masatoshi Hagiwara, Tatsutoshi Nakahata, Megumu K Saito Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model. Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model. Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model. Journal of human genetics, 64, 5, 445-458 Journal of human genetics, 64, 5, 445-458 Journal of human genetics, 64, 5, 445-458 2019/05 英語 研究論文(学術雑誌) 公開
Motoyasu Hosokawa, Akihide Takeuchi, Jun Tanihata, Kei Iida, Shin'ichi Takeda, Masatoshi Hagiwara Motoyasu Hosokawa, Akihide Takeuchi, Jun Tanihata, Kei Iida, Shin'ichi Takeda, Masatoshi Hagiwara Motoyasu Hosokawa, Akihide Takeuchi, Jun Tanihata, Kei Iida, Shin'ichi Takeda, Masatoshi Hagiwara Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy. Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy. Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy. iScience, 13, 229-242 iScience, 13, 229-242 iScience, 13, 229-242 2019/03/29 英語 研究論文(学術雑誌) 公開
Korogi Y, Gotoh S, Ikeo S, Yamamoto Y, Sone N, Tamai K, Konishi S, Nagasaki T, Matsumoto H, Ito I, Chen-Yoshikawa TF, Date H, Hagiwara M, Asaka I, Hotta A, Mishima M, Hirai T Korogi Y, Gotoh S, Ikeo S, Yamamoto Y, Sone N, Tamai K, Konishi S, Nagasaki T, Matsumoto H, Ito I, Chen-Yoshikawa TF, Date H, Hagiwara M, Asaka I, Hotta A, Mishima M, Hirai T Yohei Korogi, Shimpei Gotoh, Satoshi Ikeo, Yuki Yamamoto, Naoyuki Sone, Koji Tamai, Satoshi Konishi, Tadao Nagasaki, Hisako Matsumoto, Isao Ito, Toyofumi F Chen-Yoshikawa, Hiroshi Date, Masatoshi Hagiwara, Isao Asaka, Akitsu Hotta, Michiaki Mishima, Toyohiro Hirai In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids. In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids. In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids. Stem cell reports, 12, 3, 431-440 Stem cell reports, 12, 3, 431-440 Stem cell reports, 12, 3, 431-440 2019/03/05 英語 研究論文(学術雑誌) 公開
Bertrand Boisson, Yoshitaka Honda, Masahiko Ajiro, Jacinta Bustamante, Matthieu Bendavid, Andrew R Gennery, Yuri Kawasaki, Jose Ichishima, Mitsujiro Osawa, Hiroshi Nihira, Takeshi Shiba, Takayuki Tanaka, Maya Chrabieh, Benedetta Bigio, Hong Hur, Yuval Itan, Yupu Liang, Satoshi Okada, Kazushi Izawa, Ryuta Nishikomori, Osamu Ohara, Toshio Heike, Laurent Abel, Anne Puel, Megumu K Saito, Jean-Laurent Casanova, Masatoshi Hagiwara, Takahiro Yasumi Bertrand Boisson, Yoshitaka Honda, Masahiko Ajiro, Jacinta Bustamante, Matthieu Bendavid, Andrew R Gennery, Yuri Kawasaki, Jose Ichishima, Mitsujiro Osawa, Hiroshi Nihira, Takeshi Shiba, Takayuki Tanaka, Maya Chrabieh, Benedetta Bigio, Hong Hur, Yuval Itan, Yupu Liang, Satoshi Okada, Kazushi Izawa, Ryuta Nishikomori, Osamu Ohara, Toshio Heike, Laurent Abel, Anne Puel, Megumu K Saito, Jean-Laurent Casanova, Masatoshi Hagiwara, Takahiro Yasumi Bertrand Boisson, Yoshitaka Honda, Masahiko Ajiro, Jacinta Bustamante, Matthieu Bendavid, Andrew R Gennery, Yuri Kawasaki, Jose Ichishima, Mitsujiro Osawa, Hiroshi Nihira, Takeshi Shiba, Takayuki Tanaka, Maya Chrabieh, Benedetta Bigio, Hong Hur, Yuval Itan, Yupu Liang, Satoshi Okada, Kazushi Izawa, Ryuta Nishikomori, Osamu Ohara, Toshio Heike, Laurent Abel, Anne Puel, Megumu K Saito, Jean-Laurent Casanova, Masatoshi Hagiwara, Takahiro Yasumi Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency. Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency. Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency. The Journal of clinical investigation, 129, 2, 583-597 The Journal of clinical investigation, 129, 2, 583-597 The Journal of clinical investigation, 129, 2, 583-597 2019/02/01 英語 研究論文(学術雑誌) 公開
Sumi E, Nomura T, Asada R, Uozumi R, Tada H, Amino Y, Sawada T, Yonezawa A, Hagiwara M, Kabashima K Sumi E, Nomura T, Asada R, Uozumi R, Tada H, Amino Y, Sawada T, Yonezawa A, Hagiwara M, Kabashima K Sumi E, Nomura T, Asada R, Uozumi R, Tada H, Amino Y, Sawada T, Yonezawa A, Hagiwara M, Kabashima K Safety and Plasma Concentrations of a Cyclin-dependent Kinase 9 (CDK9) Inhibitor, FIT039, Administered by a Single Adhesive Skin Patch Applied on Normal Skin and Cutaneous Warts. Safety and Plasma Concentrations of a Cyclin-dependent Kinase 9 (CDK9) Inhibitor, FIT039, Administered by a Single Adhesive Skin Patch Applied on Normal Skin and Cutaneous Warts. Safety and Plasma Concentrations of a Cyclin-dependent Kinase 9 (CDK9) Inhibitor, FIT039, Administered by a Single Adhesive Skin Patch Applied on Normal Skin and Cutaneous Warts. Clinical drug investigation, 39, 1, 55-61 Clinical drug investigation, 39, 1, 55-61 Clinical drug investigation, 39, 1, 55-61 2018/10 公開
Hiroaki Fuji, Saori Ohmae, Naruto Noma, Masatoshi Takeiri, Hideto Yasutomi, Kazuya Izumi, Moe Ito, Masayasu Toyomoto, Soichiro Iwaki, Kenji Takemoto, Satoru Seo, Kojiro Taura, Shigeaki Hida, Mineyoshi Aoyama, Yasushi Ishihama, Masatoshi Hagiwara, Norihiko Takeda, Etsuro Hatano, Keiko Iwaisako, Shinji Uemoto, Masataka Asagiri Hiroaki Fuji, Saori Ohmae, Naruto Noma, Masatoshi Takeiri, Hideto Yasutomi, Kazuya Izumi, Moe Ito, Masayasu Toyomoto, Soichiro Iwaki, Kenji Takemoto, Satoru Seo, Kojiro Taura, Shigeaki Hida, Mineyoshi Aoyama, Yasushi Ishihama, Masatoshi Hagiwara, Norihiko Takeda, Etsuro Hatano, Keiko Iwaisako, Shinji Uemoto, Masataka Asagiri Hiroaki Fuji, Saori Ohmae, Naruto Noma, Masatoshi Takeiri, Hideto Yasutomi, Kazuya Izumi, Moe Ito, Masayasu Toyomoto, Soichiro Iwaki, Kenji Takemoto, Satoru Seo, Kojiro Taura, Shigeaki Hida, Mineyoshi Aoyama, Yasushi Ishihama, Masatoshi Hagiwara, Norihiko Takeda, Etsuro Hatano, Keiko Iwaisako, Shinji Uemoto, Masataka Asagiri Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation. Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation. Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation. Biochemical and biophysical research communications, 503, 2, 544-549 Biochemical and biophysical research communications, 503, 2, 544-549 Biochemical and biophysical research communications, 503, 2, 544-549 2018/09/05 英語 研究論文(学術雑誌) 公開
Ajiro M, Sakai H, Onogi H, Yamamoto M, Sumi E, Sawada T, Nomura T, Kabashima K, Hosoya T, Hagiwara M Ajiro M, Sakai H, Onogi H, Yamamoto M, Sumi E, Sawada T, Nomura T, Kabashima K, Hosoya T, Hagiwara M Ajiro M, Sakai H, Onogi H, Yamamoto M, Sumi E, Sawada T, Nomura T, Kabashima K, Hosoya T, Hagiwara M CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia. CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia. CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia. Clinical cancer research : an official journal of the American Association for Cancer Research, 24, 18, 4518-4528 Clinical cancer research : an official journal of the American Association for Cancer Research, 24, 18, 4518-4528 Clinical cancer research : an official journal of the American Association for Cancer Research, 24, 18, 4518-4528 2018/09 公開
Shigehito Yamada, Momoko Nagai, Masatoshi Hagiwara Shigehito Yamada, Momoko Nagai, Masatoshi Hagiwara Shigehito Yamada, Momoko Nagai, Masatoshi Hagiwara The 40th Anniversary of the Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine The 40th Anniversary of the Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine The 40th Anniversary of the Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine The Anatomical Record, 301, 6, 947-950 The Anatomical Record, 301, 6, 947-950 The Anatomical Record, 301, 6, 947-950 2018/06 研究論文(学術雑誌) 公開
Akihide Takeuchi, Kei Iida, Toshiaki Tsubota, Motoyasu Hosokawa, Masatsugu Denawa, J B Brown, Kensuke Ninomiya, Mikako Ito, Hiroshi Kimura, Takaya Abe, Hiroshi Kiyonari, Kinji Ohno, Masatoshi Hagiwara Akihide Takeuchi, Kei Iida, Toshiaki Tsubota, Motoyasu Hosokawa, Masatsugu Denawa, J B Brown, Kensuke Ninomiya, Mikako Ito, Hiroshi Kimura, Takaya Abe, Hiroshi Kiyonari, Kinji Ohno, Masatoshi Hagiwara Akihide Takeuchi, Kei Iida, Toshiaki Tsubota, Motoyasu Hosokawa, Masatsugu Denawa, J B Brown, Kensuke Ninomiya, Mikako Ito, Hiroshi Kimura, Takaya Abe, Hiroshi Kiyonari, Kinji Ohno, Masatoshi Hagiwara Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain. Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain. Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain. Cell reports, 23, 5, 1326-1341 Cell reports, 23, 5, 1326-1341 Cell reports, 23, 5, 1326-1341 2018/05/01 英語 研究論文(学術雑誌) 公開
Suguru Yoshida, Kimiyuki Kanno, Isao Kii, Yoshihiro Misawa, Masatoshi Hagiwara, Takamitsu Hosoya Suguru Yoshida, Kimiyuki Kanno, Isao Kii, Yoshihiro Misawa, Masatoshi Hagiwara, Takamitsu Hosoya Suguru Yoshida, Kimiyuki Kanno, Isao Kii, Yoshihiro Misawa, Masatoshi Hagiwara, Takamitsu Hosoya Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions Chemical Communications, 54, 30, 3705-3708 Chemical Communications, 54, 30, 3705-3708 Chemical Communications, 54, 30, 3705-3708 2018 英語 研究論文(学術雑誌) 公開
Kimura R, Ishii Y, Tomiwa K, Awaya T, Nakata M, Kato T, Okazaki S, Heike T, Hagiwara M Kimura R, Ishii Y, Tomiwa K, Awaya T, Nakata M, Kato T, Okazaki S, Heike T, Hagiwara M Kimura R, Ishii Y, Tomiwa K, Awaya T, Nakata M, Kato T, Okazaki S, Heike T, Hagiwara M Williams-Beuren Syndrome as a Potential Risk Factor for Burkitt Lymphoma. Williams-Beuren Syndrome as a Potential Risk Factor for Burkitt Lymphoma. Williams-Beuren Syndrome as a Potential Risk Factor for Burkitt Lymphoma. Frontiers in genetics, 9, 368 Frontiers in genetics, 9, 368 Frontiers in genetics, 9, 368 2018 公開
Kosuke Kawaguchi, Eiji Suzuki, Mariko Nishie, Isao Kii, Tatsuki R. Kataoka, Masahiro Hirata, Masashi Inoue, Fengling Pu, Keiko Iwaisako, Moe Tsuda, Ayane Yamaguchi, Hironori Haga, Masatoshi Hagiwara, Masakazu Toi Kosuke Kawaguchi, Eiji Suzuki, Mariko Nishie, Isao Kii, Tatsuki R. Kataoka, Masahiro Hirata, Masashi Inoue, Fengling Pu, Keiko Iwaisako, Moe Tsuda, Ayane Yamaguchi, Hironori Haga, Masatoshi Hagiwara, Masakazu Toi Kosuke Kawaguchi, Eiji Suzuki, Mariko Nishie, Isao Kii, Tatsuki R. Kataoka, Masahiro Hirata, Masashi Inoue, Fengling Pu, Keiko Iwaisako, Moe Tsuda, Ayane Yamaguchi, Hironori Haga, Masatoshi Hagiwara, Masakazu Toi Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity CANCER IMMUNOLOGY IMMUNOTHERAPY, 66, 9, 1131-1142 CANCER IMMUNOLOGY IMMUNOTHERAPY, 66, 9, 1131-1142 CANCER IMMUNOLOGY IMMUNOTHERAPY, 66, 9, 1131-1142 2017/09 英語 研究論文(学術雑誌) 公開
Kenji Ohe, Mayumi Yoshida, Akiko Nakano-Kobayashi, Motoyasu Hosokawa, Yukiya Sako, Maki Sakuma, Yukiko Okuno, Tomomi Usui, Kensuke Ninomiya, Takayuki Nojima, Naoyuki Kataoka, Masatoshi Hagiwara Kenji Ohe, Mayumi Yoshida, Akiko Nakano-Kobayashi, Motoyasu Hosokawa, Yukiya Sako, Maki Sakuma, Yukiko Okuno, Tomomi Usui, Kensuke Ninomiya, Takayuki Nojima, Naoyuki Kataoka, Masatoshi Hagiwara Kenji Ohe, Mayumi Yoshida, Akiko Nakano-Kobayashi, Motoyasu Hosokawa, Yukiya Sako, Maki Sakuma, Yukiko Okuno, Tomomi Usui, Kensuke Ninomiya, Takayuki Nojima, Naoyuki Kataoka, Masatoshi Hagiwara RBM24 promotes U1 snRNP recognition of the mutated 5 ' splice site in the IKBKAP gene of familial dysautonomia RBM24 promotes U1 snRNP recognition of the mutated 5 ' splice site in the IKBKAP gene of familial dysautonomia RBM24 promotes U1 snRNP recognition of the mutated 5 ' splice site in the IKBKAP gene of familial dysautonomia RNA, 23, 9, 1393-1403 RNA, 23, 9, 1393-1403 RNA, 23, 9, 1393-1403 2017/09 英語 研究論文(学術雑誌) 公開
Akiko Nakano-Kobayashi, Tomonari Awaya, Isao Kii, Yuto Sumida, Yukiko Okuno, Suguru Yoshida, Tomoe Sumida, Haruhisa Inoue, Takamitsu Hosoya, Masatoshi Hagiwara Akiko Nakano-Kobayashi, Tomonari Awaya, Isao Kii, Yuto Sumida, Yukiko Okuno, Suguru Yoshida, Tomoe Sumida, Haruhisa Inoue, Takamitsu Hosoya, Masatoshi Hagiwara Akiko Nakano-Kobayashi, Tomonari Awaya, Isao Kii, Yuto Sumida, Yukiko Okuno, Suguru Yoshida, Tomoe Sumida, Haruhisa Inoue, Takamitsu Hosoya, Masatoshi Hagiwara Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114, 38, 10268-10273 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114, 38, 10268-10273 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114, 38, 10268-10273 2017/09 英語 研究論文(学術雑誌) 公開
Saki Matsumoto, Kei Iida, Asako Murata, Masatsugu Denawa, Masatoshi Hagiwara, Kazuhiko Nakatani Saki Matsumoto, Kei Iida, Asako Murata, Masatsugu Denawa, Masatoshi Hagiwara, Kazuhiko Nakatani Saki Matsumoto, Kei Iida, Asako Murata, Masatsugu Denawa, Masatoshi Hagiwara, Kazuhiko Nakatani Synthetic ligand promotes gene expression by affecting GC sequence in promoter Synthetic ligand promotes gene expression by affecting GC sequence in promoter Synthetic ligand promotes gene expression by affecting GC sequence in promoter BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 27, 15, 3391-3394 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 27, 15, 3391-3394 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 27, 15, 3391-3394 2017/08 英語 研究論文(学術雑誌) 公開
Bao Ngoc Nguyen, Yukiko Okuno, Masahiko Ajiro, Kei Iida, Masatsugu Denawa, Makoto Yamamoto, Naoya Sakamoto, Hiroyuki Kagechika, Masatoshi Hagiwara Bao Ngoc Nguyen, Yukiko Okuno, Masahiko Ajiro, Kei Iida, Masatsugu Denawa, Makoto Yamamoto, Naoya Sakamoto, Hiroyuki Kagechika, Masatoshi Hagiwara Bao Ngoc Nguyen, Yukiko Okuno, Masahiko Ajiro, Kei Iida, Masatsugu Denawa, Makoto Yamamoto, Naoya Sakamoto, Hiroyuki Kagechika, Masatoshi Hagiwara Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression JOURNAL OF MEDICAL VIROLOGY, 89, 7, 1224-1234 JOURNAL OF MEDICAL VIROLOGY, 89, 7, 1224-1234 JOURNAL OF MEDICAL VIROLOGY, 89, 7, 1224-1234 2017/07 英語 研究論文(学術雑誌) 公開
Yukiya Sako, Kensuke Ninomiya, Yukiko Okuno, Masayasu Toyomoto, Atsushi Nishida, Yuka Koike, Kenji Ohe, Isao Kii, Suguru Yoshida, Naohiro Hashimoto, Takamitsu Hosoya, Masafumi Matsuo, Masatoshi Hagiwara Yukiya Sako, Kensuke Ninomiya, Yukiko Okuno, Masayasu Toyomoto, Atsushi Nishida, Yuka Koike, Kenji Ohe, Isao Kii, Suguru Yoshida, Naohiro Hashimoto, Takamitsu Hosoya, Masafumi Matsuo, Masatoshi Hagiwara Yukiya Sako, Kensuke Ninomiya, Yukiko Okuno, Masayasu Toyomoto, Atsushi Nishida, Yuka Koike, Kenji Ohe, Isao Kii, Suguru Yoshida, Naohiro Hashimoto, Takamitsu Hosoya, Masafumi Matsuo, Masatoshi Hagiwara Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy SCIENTIFIC REPORTS, 7, 46126 SCIENTIFIC REPORTS, 7, 46126 SCIENTIFIC REPORTS, 7, 46126 2017/05 英語 研究論文(学術雑誌) 公開
Ohta H, Kurimoto K, Okamoto I, Nakamura T, Yabuta Y, Miyauchi H, Yamamoto T, Okuno Y, Hagiwara M, Shirane K, Sasaki H, Saitou M Ohta H, Kurimoto K, Okamoto I, Nakamura T, Yabuta Y, Miyauchi H, Yamamoto T, Okuno Y, Hagiwara M, Shirane K, Sasaki H, Saitou M Ohta H, Kurimoto K, Okamoto I, Nakamura T, Yabuta Y, Miyauchi H, Yamamoto T, Okuno Y, Hagiwara M, Shirane K, Sasaki H, Saitou M In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate. In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate. In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate. The EMBO journal, 36, 13, 1888-1907 The EMBO journal, 36, 13, 1888-1907 The EMBO journal, 36, 13, 1888-1907 2017/05 研究論文(学術雑誌) 公開
Saori Ohmae, Naruto Noma, Masayasu Toyomoto, Masahiro Shinohara, Masatoshi Takeiri, Hiroaki Fuji, Kenji Takemoto, Keiko Iwaisako, Tomoko Fujita, Norihiko Takeda, Makoto Kawatani, Mineyoshi Aoyama, Masatoshi Hagiwara, Yasushi Ishihama, Masataka Asagiri Saori Ohmae, Naruto Noma, Masayasu Toyomoto, Masahiro Shinohara, Masatoshi Takeiri, Hiroaki Fuji, Kenji Takemoto, Keiko Iwaisako, Tomoko Fujita, Norihiko Takeda, Makoto Kawatani, Mineyoshi Aoyama, Masatoshi Hagiwara, Yasushi Ishihama, Masataka Asagiri Saori Ohmae, Naruto Noma, Masayasu Toyomoto, Masahiro Shinohara, Masatoshi Takeiri, Hiroaki Fuji, Kenji Takemoto, Keiko Iwaisako, Tomoko Fujita, Norihiko Takeda, Makoto Kawatani, Mineyoshi Aoyama, Masatoshi Hagiwara, Yasushi Ishihama, Masataka Asagiri Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K SCIENTIFIC REPORTS, 7, 1-12 SCIENTIFIC REPORTS, 7, 1-12 SCIENTIFIC REPORTS, 7, 1-12 2017/03 英語 研究論文(学術雑誌) 公開
Dan O Wang, Kensuke Ninomiya, Chihiro Mori, Ayako Koyama, Martine Haan, Makoto Kitabatake, Masatoshi Hagiwara, Kazuhiro Chida, Shin-Ichiro Takahashi, Mutsuhito Ohno, Naoyuki Kataoka Dan O Wang, Kensuke Ninomiya, Chihiro Mori, Ayako Koyama, Martine Haan, Makoto Kitabatake, Masatoshi Hagiwara, Kazuhiro Chida, Shin-Ichiro Takahashi, Mutsuhito Ohno, Naoyuki Kataoka Dan O Wang, Kensuke Ninomiya, Chihiro Mori, Ayako Koyama, Martine Haan, Makoto Kitabatake, Masatoshi Hagiwara, Kazuhiro Chida, Shin-Ichiro Takahashi, Mutsuhito Ohno, Naoyuki Kataoka Transport Granules Bound with Nuclear Cap Binding Protein and Exon Junction Complex Are Associated with Microtubules and Spatially Separated from eIF4E Granules and P Bodies in Human Neuronal Processes. Transport Granules Bound with Nuclear Cap Binding Protein and Exon Junction Complex Are Associated with Microtubules and Spatially Separated from eIF4E Granules and P Bodies in Human Neuronal Processes. Transport Granules Bound with Nuclear Cap Binding Protein and Exon Junction Complex Are Associated with Microtubules and Spatially Separated from eIF4E Granules and P Bodies in Human Neuronal Processes. Frontiers in molecular biosciences, 4, 93-93 Frontiers in molecular biosciences, 4, 93-93 Frontiers in molecular biosciences, 4, 93-93 2017 英語 公開
Candeias MM, Hagiwara M, Matsuda M Candeias MM, Hagiwara M, Matsuda M Marco M. Candeias, Masatoshi Hagiwara, Michiyuki Matsuda Cancer-specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis. Cancer-specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis. Cancer-specific mutations in p53 induce the translation of 160p53 promoting tumorigenesis EMBO reports, 17, 11, 1542-1551 EMBO reports, 17, 11, 1542-1551 EMBO REPORTS, 17, 11, 1542-1551 2016/11 英語 研究論文(学術雑誌) 公開
Tomohisa Tanaka, Kaori Okuyama-Dobashi, Shuko Murakami, Wenjia Chen, Toru Okamoto, Keiji Ueda, Takamitsu Hosoya, Yoshiharu Matsuura, Akihide Ryo, Yasuhito Tanaka, Masatoshi Hagiwara, Kohji Moriishi Tomohisa Tanaka, Kaori Okuyama-Dobashi, Shuko Murakami, Wenjia Chen, Toru Okamoto, Keiji Ueda, Takamitsu Hosoya, Yoshiharu Matsuura, Akihide Ryo, Yasuhito Tanaka, Masatoshi Hagiwara, Kohji Moriishi Tomohisa Tanaka, Kaori Okuyama-Dobashi, Shuko Murakami, Wenjia Chen, Toru Okamoto, Keiji Ueda, Takamitsu Hosoya, Yoshiharu Matsuura, Akihide Ryo, Yasuhito Tanaka, Masatoshi Hagiwara, Kohji Moriishi Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation ANTIVIRAL RESEARCH, 133, 156-164 ANTIVIRAL RESEARCH, 133, 156-164 ANTIVIRAL RESEARCH, 133, 156-164 2016/09 英語 研究論文(学術雑誌) 公開
Isao Kii, Yuto Sumida, Toshiyasu Goto, Rie Sonamoto, Yukiko Okuno, Suguru Yoshida, Tomoe Kato-Sumida, Yuka Koike, Minako Abe, Yosuke Nonaka, Teikichi Ikura, Nobutoshi Ito, Hiroshi Shibuya, Takamitsu Hosoya, Masatoshi Hagiwara Isao Kii, Yuto Sumida, Toshiyasu Goto, Rie Sonamoto, Yukiko Okuno, Suguru Yoshida, Tomoe Kato-Sumida, Yuka Koike, Minako Abe, Yosuke Nonaka, Teikichi Ikura, Nobutoshi Ito, Hiroshi Shibuya, Takamitsu Hosoya, Masatoshi Hagiwara Isao Kii, Yuto Sumida, Toshiyasu Goto, Rie Sonamoto, Yukiko Okuno, Suguru Yoshida, Tomoe Kato-Sumida, Yuka Koike, Minako Abe, Yosuke Nonaka, Teikichi Ikura, Nobutoshi Ito, Hiroshi Shibuya, Takamitsu Hosoya, Masatoshi Hagiwara Selective inhibition of the kinase DYRK1A by targeting its folding process Selective inhibition of the kinase DYRK1A by targeting its folding process Selective inhibition of the kinase DYRK1A by targeting its folding process NATURE COMMUNICATIONS, 7, 11391 NATURE COMMUNICATIONS, 7, 11391 NATURE COMMUNICATIONS, 7, 11391 2016/04 英語 研究論文(学術雑誌) 公開
Mika Okamoto, Akemi Hidaka, Masaaki Toyama, Takamitsu Hosoya, Makoto Yamamoto, Masatoshi Hagiwara, Masanori Baba Mika Okamoto, Akemi Hidaka, Masaaki Toyama, Takamitsu Hosoya, Makoto Yamamoto, Masatoshi Hagiwara, Masanori Baba Mika Okamoto, Akemi Hidaka, Masaaki Toyama, Takamitsu Hosoya, Makoto Yamamoto, Masatoshi Hagiwara, Masanori Baba Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039 Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039 Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039 ANTIVIRAL RESEARCH, 123, 1-4 ANTIVIRAL RESEARCH, 123, 1-4 ANTIVIRAL RESEARCH, 123, 1-4 2015/11 英語 研究論文(学術雑誌) 公開
Maki Sakuma, Kei Iida, Masatoshi Hagiwara Maki Sakuma, Kei Iida, Masatoshi Hagiwara Maki Sakuma, Kei Iida, Masatoshi Hagiwara Deciphering targeting rules of splicing modulator compounds: case of TG003 Deciphering targeting rules of splicing modulator compounds: case of TG003 Deciphering targeting rules of splicing modulator compounds: case of TG003 BMC MOLECULAR BIOLOGY, 16, 16 BMC MOLECULAR BIOLOGY, 16, 16 BMC MOLECULAR BIOLOGY, 16, 16 2015/09 英語 研究論文(学術雑誌) 公開
Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, Kii I, Nishiyama T, Kakita A, Takeda H, Takeuchi A, Arai Y, Ito A, Komura H, Hirao H, Satomura K, Inoue M, Muramatsu S, Matsui K, Tada M, Sato M, Saijo E, Shigemitsu Y, Sakai S, Umetsu Y, Goda N, Takino N, Takahashi H, Hagiwara M, Sawasaki T, Iwasaki G, Nakamura Y, Nabeshima Y, Teplow DB, Hoshi M Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, Kii I, Nishiyama T, Kakita A, Takeda H, Takeuchi A, Arai Y, Ito A, Komura H, Hirao H, Satomura K, Inoue M, Muramatsu S, Matsui K, Tada M, Sato M, Saijo E, Shigemitsu Y, Sakai S, Umetsu Y, Goda N, Takino N, Takahashi H, Hagiwara M, Sawasaki T, Iwasaki G, Nakamura Y, Nabeshima Y, Teplow DB, Hoshi M Takayuki Ohnishi, Masako Yanazawa, Tomoya Sasahara, Yasuki Kitamura, Hidekazu Hiroaki, Yugo Fukazawa, Isao Kii, Takashi Nishiyama, Akiyoshi Kakita, Hiroyuki Takeda, Akihide Takeuchi, Yoshie Arai, Akane Ito, Hitomi Komura, Hajime Hirao, Kaori Satomura, Masafumi Inoue, Shin-ichi Muramatsu, Ko Matsui, Mari Tada, Michio Sato, Eri Saijo, Yoshiki Shigemitsu, Satoko Sakai, Yoshitaka Umetsu, Natsuko Goda, Naomi Takino, Hitoshi Takahashi, Masatoshi Hagiwara, Tatsuya Sawasaki, Genji Iwasaki, Yu Nakamura, Yo-ichi Nabeshima, David B. Teplow, Minako Hoshi Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly. Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly. Na, K-ATPase alpha 3 is a death target of Alzheimer patient amyloid-beta assembly Proceedings of the National Academy of Sciences of the United States of America, 112, 32, E4465-E4474 Proceedings of the National Academy of Sciences of the United States of America, 112, 32, E4465-E4474 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112, 32, E4465-E4474 2015/08 英語 研究論文(学術雑誌) 公開
Rie Sonamoto, Isao Kii, Yuka Koike, Yuto Sumida, Tomoe Kato-Sumida, Yukiko Okuno, Takamitsu Hosoya, Masatoshi Hagiwara Rie Sonamoto, Isao Kii, Yuka Koike, Yuto Sumida, Tomoe Kato-Sumida, Yukiko Okuno, Takamitsu Hosoya, Masatoshi Hagiwara Rie Sonamoto, Isao Kii, Yuka Koike, Yuto Sumida, Tomoe Kato-Sumida, Yukiko Okuno, Takamitsu Hosoya, Masatoshi Hagiwara Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ SCIENTIFIC REPORTS, 5, 12728 SCIENTIFIC REPORTS, 5, 12728 SCIENTIFIC REPORTS, 5, 12728 2015/08 英語 研究論文(学術雑誌) 公開
Satoshi Morooka, Mitsuteru Hoshina, Isao Kii, Takayoshi Okabe, Hirotatsu Kojima, Naoko Inoue, Yukiko Okuno, Masatsugu Denawa, Suguru Yoshida, Junichi Fukuhara, Kensuke Ninomiya, Teikichi Ikura, Toshio Furuya, Tetsuo Nagano, Kousuke Noda, Susumu Ishida, Takamitsu Hosoya, Nobutoshi Ito, Nagahisa Yoshimura, Masatoshi Hagiwara Satoshi Morooka, Mitsuteru Hoshina, Isao Kii, Takayoshi Okabe, Hirotatsu Kojima, Naoko Inoue, Yukiko Okuno, Masatsugu Denawa, Suguru Yoshida, Junichi Fukuhara, Kensuke Ninomiya, Teikichi Ikura, Toshio Furuya, Tetsuo Nagano, Kousuke Noda, Susumu Ishida, Takamitsu Hosoya, Nobutoshi Ito, Nagahisa Yoshimura, Masatoshi Hagiwara Satoshi Morooka, Mitsuteru Hoshina, Isao Kii, Takayoshi Okabe, Hirotatsu Kojima, Naoko Inoue, Yukiko Okuno, Masatsugu Denawa, Suguru Yoshida, Junichi Fukuhara, Kensuke Ninomiya, Teikichi Ikura, Toshio Furuya, Tetsuo Nagano, Kousuke Noda, Susumu Ishida, Takamitsu Hosoya, Nobutoshi Ito, Nagahisa Yoshimura, Masatoshi Hagiwara Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice MOLECULAR PHARMACOLOGY, 88, 2, 316-325 MOLECULAR PHARMACOLOGY, 88, 2, 316-325 MOLECULAR PHARMACOLOGY, 88, 2, 316-325 2015/08 英語 研究論文(学術雑誌) 公開
So Masaki, Isao Kii, Yuto Sumida, Tomoe Kato-Sumida, Yasushi Ogawa, Nobutoshi Ito, Mitsuhiro Nakamura, Rie Sonamoto, Naoyuki Kataoka, Takamitsu Hosoya, Masatoshi Hagiwara So Masaki, Isao Kii, Yuto Sumida, Tomoe Kato-Sumida, Yasushi Ogawa, Nobutoshi Ito, Mitsuhiro Nakamura, Rie Sonamoto, Naoyuki Kataoka, Takamitsu Hosoya, Masatoshi Hagiwara So Masaki, Isao Kii, Yuto Sumida, Tomoe Kato-Sumida, Yasushi Ogawa, Nobutoshi Ito, Mitsuhiro Nakamura, Rie Sonamoto, Naoyuki Kataoka, Takamitsu Hosoya, Masatoshi Hagiwara Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis BIOORGANIC & MEDICINAL CHEMISTRY, 23, 15, 4434-4441 BIOORGANIC & MEDICINAL CHEMISTRY, 23, 15, 4434-4441 BIOORGANIC & MEDICINAL CHEMISTRY, 23, 15, 4434-4441 2015/08 英語 研究論文(学術雑誌) 公開
Mayumi Yoshida, Naoyuki Kataoka, Kenjyo Miyauchi, Kenji Ohe, Kei Iida, Suguru Yoshida, Takayuki Nojima, Yukiko Okuno, Hiroshi Onogi, Tomomi Usui, Akihide Takeuchi, Takamitsu Hosoya, Tsutomu Suzuki, Masatoshi Hagiwaraa Mayumi Yoshida, Naoyuki Kataoka, Kenjyo Miyauchi, Kenji Ohe, Kei Iida, Suguru Yoshida, Takayuki Nojima, Yukiko Okuno, Hiroshi Onogi, Tomomi Usui, Akihide Takeuchi, Takamitsu Hosoya, Tsutomu Suzuki, Masatoshi Hagiwaraa Mayumi Yoshida, Naoyuki Kataoka, Kenjyo Miyauchi, Kenji Ohe, Kei Iida, Suguru Yoshida, Takayuki Nojima, Yukiko Okuno, Hiroshi Onogi, Tomomi Usui, Akihide Takeuchi, Takamitsu Hosoya, Tsutomu Suzuki, Masatoshi Hagiwaraa Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112, 9, 2764-2769 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112, 9, 2764-2769 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112, 9, 2764-2769 2015/03 英語 研究論文(学術雑誌) 公開
Kuwasako K, Takahashi M, Unzai S, Tsuda K, Yoshikawa S, He F, Kobayashi N, Güntert P, Shirouzu M, Ito T, Tanaka A, Yokoyama S, Hagiwara M, Kuroyanagi H, Muto Y Kuwasako K, Takahashi M, Unzai S, Tsuda K, Yoshikawa S, He F, Kobayashi N, Güntert P, Shirouzu M, Ito T, Tanaka A, Yokoyama S, Hagiwara M, Kuroyanagi H, Muto Y Kuwasako K, Takahashi M, Unzai S, Tsuda K, Yoshikawa S, He F, Kobayashi N, Güntert P, Shirouzu M, Ito T, Tanaka A, Yokoyama S, Hagiwara M, Kuroyanagi H, Muto Y RBFOX and SUP-12 sandwich a guanine base to form a stable complex and regulate tissue-specific splicing RBFOX and SUP-12 sandwich a guanine base to form a stable complex and regulate tissue-specific splicing RBFOX and SUP-12 sandwich a guanine base to form a stable complex and regulate tissue-specific splicing Nat. Struct. Mol. Biol., 21, 9, 778-786 Nat. Struct. Mol. Biol., 21, 9, 778-786 Nat. Struct. Mol. Biol., 21, 9, 778-786 2014/09 公開
Makoto Yamamoto, Hiroshi Onogi, Isao Kii, Suguru Yoshida, Kei Iida, Hiroyuki Sakai, Minako Abe, Toshiaki Tsubota, Nobutoshi Ito, Takamitsu Hosoya, Masatoshi Hagiwara Makoto Yamamoto, Hiroshi Onogi, Isao Kii, Suguru Yoshida, Kei Iida, Hiroyuki Sakai, Minako Abe, Toshiaki Tsubota, Nobutoshi Ito, Takamitsu Hosoya, Masatoshi Hagiwara Makoto Yamamoto, Hiroshi Onogi, Isao Kii, Suguru Yoshida, Kei Iida, Hiroyuki Sakai, Minako Abe, Toshiaki Tsubota, Nobutoshi Ito, Takamitsu Hosoya, Masatoshi Hagiwara CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses JOURNAL OF CLINICAL INVESTIGATION, 124, 8, 3479-3488 JOURNAL OF CLINICAL INVESTIGATION, 124, 8, 3479-3488 JOURNAL OF CLINICAL INVESTIGATION, 124, 8, 3479-3488 2014/08 英語 研究論文(学術雑誌) 公開
Takashi Kurihara, Eri Sakurai, Masayasu Toyomoto, Isao Kii, Daisuke Kawamoto, Toshihide Asada, Tsutomu Tanabe, Megumu Yoshimura, Masatoshi Hagiwara, Atsuro Miyata Takashi Kurihara, Eri Sakurai, Masayasu Toyomoto, Isao Kii, Daisuke Kawamoto, Toshihide Asada, Tsutomu Tanabe, Megumu Yoshimura, Masatoshi Hagiwara, Atsuro Miyata Takashi Kurihara, Eri Sakurai, Masayasu Toyomoto, Isao Kii, Daisuke Kawamoto, Toshihide Asada, Tsutomu Tanabe, Megumu Yoshimura, Masatoshi Hagiwara, Atsuro Miyata Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors MOLECULAR PAIN, 10, 17 MOLECULAR PAIN, 10, 17 MOLECULAR PAIN, 10, 17 2014/03 英語 研究論文(学術雑誌) 公開
Melissa V. Gammons, Oleg Fedorov, David Ivison, Chunyun Du, Tamsyn Clark, Claire Hopkins, Masatoshi Hagiwara, Andrew D. Dick, Russell Cox, Steven J. Harper, Jules C. Hancox, Stefan Knapp, David O. Bates Melissa V. Gammons, Oleg Fedorov, David Ivison, Chunyun Du, Tamsyn Clark, Claire Hopkins, Masatoshi Hagiwara, Andrew D. Dick, Russell Cox, Steven J. Harper, Jules C. Hancox, Stefan Knapp, David O. Bates Melissa V. Gammons, Oleg Fedorov, David Ivison, Chunyun Du, Tamsyn Clark, Claire Hopkins, Masatoshi Hagiwara, Andrew D. Dick, Russell Cox, Steven J. Harper, Jules C. Hancox, Stefan Knapp, David O. Bates Topical Antiangiogenic SRPK1 Inhibitors Reduce Choroidal Neovascularization in Rodent Models of Exudative AMD Topical Antiangiogenic SRPK1 Inhibitors Reduce Choroidal Neovascularization in Rodent Models of Exudative AMD Topical Antiangiogenic SRPK1 Inhibitors Reduce Choroidal Neovascularization in Rodent Models of Exudative AMD INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54, 9, 6052-6062 INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54, 9, 6052-6062 INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54, 9, 6052-6062 2013/09 英語 研究論文(学術雑誌) 公開
Natividad Pozo, Cristina Zahonero, Paloma Fernandez, Jose M. Linares, Angel Ayuso, Masatoshi Hagiwara, Angel Perez, Jose R. Ricoy, Aurelio Hernandez-Lain, Juan M. Sepulveda, Pilar Sanchez-Gomez Natividad Pozo, Cristina Zahonero, Paloma Fernandez, Jose M. Linares, Angel Ayuso, Masatoshi Hagiwara, Angel Perez, Jose R. Ricoy, Aurelio Hernandez-Lain, Juan M. Sepulveda, Pilar Sanchez-Gomez Natividad Pozo, Cristina Zahonero, Paloma Fernandez, Jose M. Linares, Angel Ayuso, Masatoshi Hagiwara, Angel Perez, Jose R. Ricoy, Aurelio Hernandez-Lain, Juan M. Sepulveda, Pilar Sanchez-Gomez Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth JOURNAL OF CLINICAL INVESTIGATION, 123, 6, 2475-2487 JOURNAL OF CLINICAL INVESTIGATION, 123, 6, 2475-2487 JOURNAL OF CLINICAL INVESTIGATION, 123, 6, 2475-2487 2013/06 英語 研究論文(学術雑誌) 公開
Hidehito Kuroyanagi, Yohei Watanabe, Yutaka Suzuki, Masatoshi Hagiwara Hidehito Kuroyanagi, Yohei Watanabe, Yutaka Suzuki, Masatoshi Hagiwara Hidehito Kuroyanagi, Yohei Watanabe, Yutaka Suzuki, Masatoshi Hagiwara Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans Nucleic Acids Research, 41, 7, 4015-4025 Nucleic Acids Research, 41, 7, 4015-4025 Nucleic Acids Research, 41, 7, 4015-4025 2013/04 英語 研究論文(学術雑誌) 公開
Hidehito Kuroyanagi, Yohei Watanabe, Masatoshi Hagiwara Hidehito Kuroyanagi, Yohei Watanabe, Masatoshi Hagiwara Hidehito Kuroyanagi, Yohei Watanabe, Masatoshi Hagiwara CELF Family RNA-Binding Protein UNC-75 Regulates Two Sets of Mutually Exclusive Exons of the unc-32 Gene in Neuron-Specific Manners in Caenorhabditis elegans CELF Family RNA-Binding Protein UNC-75 Regulates Two Sets of Mutually Exclusive Exons of the unc-32 Gene in Neuron-Specific Manners in Caenorhabditis elegans CELF Family RNA-Binding Protein UNC-75 Regulates Two Sets of Mutually Exclusive Exons of the unc-32 Gene in Neuron-Specific Manners in Caenorhabditis elegans PLoS Genetics, 9, 2, e1003337 PLoS Genetics, 9, 2, e1003337 PLoS Genetics, 9, 2, e1003337 2013/02 英語 研究論文(学術雑誌) 公開
Dong Z, Noda K, Kanda A, Fukuhara J, Ando R, Murata M, Saito W, Hagiwara M, Ishida S Dong Z, Noda K, Kanda A, Fukuhara J, Ando R, Murata M, Saito W, Hagiwara M, Ishida S Dong Z, Noda K, Kanda A, Fukuhara J, Ando R, Murata M, Saito W, Hagiwara M, Ishida S Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization. Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization. Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization. Mol Vis. 19:536-543, 19, 536-543 Mol Vis. 19:536-543, 19, 536-543 Mol Vis. 19:536-543, 19, 536-543 2013 英語 研究論文(学術雑誌) 公開
Naoyuki Kataoka, Izumi Dobashi, Masatoshi Hagiwara, Mutsuhito Ohno Naoyuki Kataoka, Izumi Dobashi, Masatoshi Hagiwara, Mutsuhito Ohno Naoyuki Kataoka, Izumi Dobashi, Masatoshi Hagiwara, Mutsuhito Ohno hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity. hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity. hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity. Scientific reports, 3, 1090-1090 Scientific reports, 3, 1090-1090 Scientific reports, 3, 1090-1090 2013 英語 研究論文(学術雑誌) 公開
Akiko Kusano-Kitazume, Naoya Sakamoto, Yukiko Okuno, Yuko Sekine-Osajima, Mina Nakagawa, Sei Kakinuma, Kei Kiyohashi, Sayuri Nitta, Miyako Murakawa, Seishin Azuma, Yuki Nishimura-Sakurai, Masatoshi Hagiwara, Mamoru Watanabe Akiko Kusano-Kitazume, Naoya Sakamoto, Yukiko Okuno, Yuko Sekine-Osajima, Mina Nakagawa, Sei Kakinuma, Kei Kiyohashi, Sayuri Nitta, Miyako Murakawa, Seishin Azuma, Yuki Nishimura-Sakurai, Masatoshi Hagiwara, Mamoru Watanabe Akiko Kusano-Kitazume, Naoya Sakamoto, Yukiko Okuno, Yuko Sekine-Osajima, Mina Nakagawa, Sei Kakinuma, Kei Kiyohashi, Sayuri Nitta, Miyako Murakawa, Seishin Azuma, Yuki Nishimura-Sakurai, Masatoshi Hagiwara, Mamoru Watanabe Identification of Novel N-(Morpholine-4-Carbonyloxy) Amidine Compounds as Potent Inhibitors against Hepatitis C Virus Replication Identification of Novel N-(Morpholine-4-Carbonyloxy) Amidine Compounds as Potent Inhibitors against Hepatitis C Virus Replication Identification of Novel N-(Morpholine-4-Carbonyloxy) Amidine Compounds as Potent Inhibitors against Hepatitis C Virus Replication ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56, 3, 1315-1323 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56, 3, 1315-1323 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56, 3, 1315-1323 2012/03 英語 研究論文(学術雑誌) 公開
Noriko Saitoh, Chiyomi Sakamoto, Masatoshi Hagiwara, Lourdes T. Agredano-Moreno, Luis Felipe Jimenez-Garcia, Mitsuyoshi Nakao Noriko Saitoh, Chiyomi Sakamoto, Masatoshi Hagiwara, Lourdes T. Agredano-Moreno, Luis Felipe Jimenez-Garcia, Mitsuyoshi Nakao Noriko Saitoh, Chiyomi Sakamoto, Masatoshi Hagiwara, Lourdes T. Agredano-Moreno, Luis Felipe Jimenez-Garcia, Mitsuyoshi Nakao The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2 The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2 The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2 MOLECULAR BIOLOGY OF THE CELL, 23, 6, 1115-1128 MOLECULAR BIOLOGY OF THE CELL, 23, 6, 1115-1128 MOLECULAR BIOLOGY OF THE CELL, 23, 6, 1115-1128 2012/03 英語 研究論文(学術雑誌) 公開
Ohno G, Ono K, Togo M, Watanabe Y, Ono S, Hagiwara M, Kuroyanagi H Ohno G, Ono K, Togo M, Watanabe Y, Ono S, Hagiwara M, Kuroyanagi H Ohno G, Ono K, Togo M, Watanabe Y, Ono S, Hagiwara M, Kuroyanagi H Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in C. elegans. Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in C. elegans. Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in C. elegans. PLoS Genet 8(10) e1002991., 8, 10, e1002991 PLoS Genet 8(10) e1002991., 8, 10, e1002991 PLoS Genet 8(10) e1002991., 8, 10, e1002991 2012 英語 研究論文(学術雑誌) 公開
Elianna M. Amin, Sebastian Oltean, Jing Hua, Melissa V. R. Gammons, Maryam Hamdollah-Zadeh, Gavin I. Welsh, Man-Kim Cheung, Lan Ni, Satoru Kase, Emma S. Renne, Kirsty E. Symonds, Dawid G. Nowak, Brigitte Royer-Pokora, Moin A. Saleem, Masatoshi Hagiwara, Valerie A. Schumacher, Steven J. Harper, David R. Hinton, David O. Bates, Michael R. Ladomery Elianna M. Amin, Sebastian Oltean, Jing Hua, Melissa V. R. Gammons, Maryam Hamdollah-Zadeh, Gavin I. Welsh, Man-Kim Cheung, Lan Ni, Satoru Kase, Emma S. Renne, Kirsty E. Symonds, Dawid G. Nowak, Brigitte Royer-Pokora, Moin A. Saleem, Masatoshi Hagiwara, Valerie A. Schumacher, Steven J. Harper, David R. Hinton, David O. Bates, Michael R. Ladomery Elianna M. Amin, Sebastian Oltean, Jing Hua, Melissa V. R. Gammons, Maryam Hamdollah-Zadeh, Gavin I. Welsh, Man-Kim Cheung, Lan Ni, Satoru Kase, Emma S. Renne, Kirsty E. Symonds, Dawid G. Nowak, Brigitte Royer-Pokora, Moin A. Saleem, Masatoshi Hagiwara, Valerie A. Schumacher, Steven J. Harper, David R. Hinton, David O. Bates, Michael R. Ladomery WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing CANCER CELL, 20, 6, 768-780 CANCER CELL, 20, 6, 768-780 CANCER CELL, 20, 6, 768-780 2011/12 英語 研究論文(学術雑誌) 公開
Kensuke Ninomiya, Naoyuki Kataoka, Masatoshi Hagiwara Kensuke Ninomiya, Naoyuki Kataoka, Masatoshi Hagiwara Kensuke Ninomiya, Naoyuki Kataoka, Masatoshi Hagiwara Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor JOURNAL OF CELL BIOLOGY, 195, 1, 27-40 JOURNAL OF CELL BIOLOGY, 195, 1, 27-40 JOURNAL OF CELL BIOLOGY, 195, 1, 27-40 2011/10 英語 研究論文(学術雑誌) 公開
Naoyuki Kataoka, Michael D. Diem, Mayumi Yoshida, Chihiro Hatai, Izumi Dobashi, Gideon Dreyfuss, Masatoshi Hagiwara, Mutsuhito Ohno Naoyuki Kataoka, Michael D. Diem, Mayumi Yoshida, Chihiro Hatai, Izumi Dobashi, Gideon Dreyfuss, Masatoshi Hagiwara, Mutsuhito Ohno Naoyuki Kataoka, Michael D. Diem, Mayumi Yoshida, Chihiro Hatai, Izumi Dobashi, Gideon Dreyfuss, Masatoshi Hagiwara, Mutsuhito Ohno Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA SCIENTIFIC REPORTS, 1, 92 SCIENTIFIC REPORTS, 1, 92 SCIENTIFIC REPORTS, 1, 92 2011/09 英語 研究論文(学術雑誌) 公開
Azlinda Anwar, Takamitsu Hosoya, Kok Mun Leong, Hiroshi Onogi, Yukiko Okuno, Toshiyuki Hiramatsu, Hiroko Koyama, Masaaki Suzuki, Masatoshi Hagiwara, Mariano A. Garcia-Blanco Azlinda Anwar, Takamitsu Hosoya, Kok Mun Leong, Hiroshi Onogi, Yukiko Okuno, Toshiyuki Hiramatsu, Hiroko Koyama, Masaaki Suzuki, Masatoshi Hagiwara, Mariano A. Garcia-Blanco Azlinda Anwar, Takamitsu Hosoya, Kok Mun Leong, Hiroshi Onogi, Yukiko Okuno, Toshiyuki Hiramatsu, Hiroko Koyama, Masaaki Suzuki, Masatoshi Hagiwara, Mariano A. Garcia-Blanco The Kinase Inhibitor SFV785 Dislocates Dengue Virus Envelope Protein from the Replication Complex and Blocks Virus Assembly The Kinase Inhibitor SFV785 Dislocates Dengue Virus Envelope Protein from the Replication Complex and Blocks Virus Assembly The Kinase Inhibitor SFV785 Dislocates Dengue Virus Envelope Protein from the Replication Complex and Blocks Virus Assembly PLOS ONE, 6, 8, e23246 PLOS ONE, 6, 8, e23246 PLOS ONE, 6, 8, e23246 2011/08 英語 研究論文(学術雑誌) 公開
Mansour Debdab, Francois Carreaux, Steven Renault, Meera Soundararajan, Oleg Fedorov, Panagis Filippakopoulos, Olivier Lozach, Lucie Babault, Tania Tahtouh, Blandine Baratte, Yasushi Ogawa, Masatoshi Hagiwara, Andreas Eisenreich, Ursula Rauch, Stefan Knapp, Laurent Meijer, Jean-Pierre Bazureau Mansour Debdab, Francois Carreaux, Steven Renault, Meera Soundararajan, Oleg Fedorov, Panagis Filippakopoulos, Olivier Lozach, Lucie Babault, Tania Tahtouh, Blandine Baratte, Yasushi Ogawa, Masatoshi Hagiwara, Andreas Eisenreich, Ursula Rauch, Stefan Knapp, Laurent Meijer, Jean-Pierre Bazureau Mansour Debdab, Francois Carreaux, Steven Renault, Meera Soundararajan, Oleg Fedorov, Panagis Filippakopoulos, Olivier Lozach, Lucie Babault, Tania Tahtouh, Blandine Baratte, Yasushi Ogawa, Masatoshi Hagiwara, Andreas Eisenreich, Ursula Rauch, Stefan Knapp, Laurent Meijer, Jean-Pierre Bazureau Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing JOURNAL OF MEDICINAL CHEMISTRY, 54, 12, 4172-4186 JOURNAL OF MEDICINAL CHEMISTRY, 54, 12, 4172-4186 JOURNAL OF MEDICINAL CHEMISTRY, 54, 12, 4172-4186 2011/06 英語 研究論文(学術雑誌) 公開
Atsushi Nishida, Naoyuki Kataoka, Yasuhiro Takeshima, Mariko Yagi, Hiroyuki Awano, Mitsunori Ota, Kyoko Itoh, Masatoshi Hagiwara, Masafumi Matsuo Atsushi Nishida, Naoyuki Kataoka, Yasuhiro Takeshima, Mariko Yagi, Hiroyuki Awano, Mitsunori Ota, Kyoko Itoh, Masatoshi Hagiwara, Masafumi Matsuo Atsushi Nishida, Naoyuki Kataoka, Yasuhiro Takeshima, Mariko Yagi, Hiroyuki Awano, Mitsunori Ota, Kyoko Itoh, Masatoshi Hagiwara, Masafumi Matsuo Chemical treatment enhances skipping of a mutated exon in the dystrophin gene Chemical treatment enhances skipping of a mutated exon in the dystrophin gene Chemical treatment enhances skipping of a mutated exon in the dystrophin gene NATURE COMMUNICATIONS, 2, 308 NATURE COMMUNICATIONS, 2, 308 NATURE COMMUNICATIONS, 2, 308 2011/05 英語 研究論文(学術雑誌) 公開
Sunder Sims-Lucas, Brian Cusack, Jeffrey Baust, Veraragavan P. Eswarakumar, Hagiwara Masatoshi, Akihide Takeuchi, Carlton M. Bates Sunder Sims-Lucas, Brian Cusack, Jeffrey Baust, Veraragavan P. Eswarakumar, Hagiwara Masatoshi, Akihide Takeuchi, Carlton M. Bates Sunder Sims-Lucas, Brian Cusack, Jeffrey Baust, Veraragavan P. Eswarakumar, Hagiwara Masatoshi, Akihide Takeuchi, Carlton M. Bates Fgfr1 and the IIIc Isoform of Fgfr2 Play Critical Roles in the Metanephric Mesenchyme Mediating Early Inductive Events in Kidney Development Fgfr1 and the IIIc Isoform of Fgfr2 Play Critical Roles in the Metanephric Mesenchyme Mediating Early Inductive Events in Kidney Development Fgfr1 and the IIIc Isoform of Fgfr2 Play Critical Roles in the Metanephric Mesenchyme Mediating Early Inductive Events in Kidney Development DEVELOPMENTAL DYNAMICS, 240, 1, 240-249 DEVELOPMENTAL DYNAMICS, 240, 1, 240-249 DEVELOPMENTAL DYNAMICS, 240, 1, 240-249 2011/01 英語 研究論文(学術雑誌) 公開
Yasushi Ogawa, Yosuke Nonaka, Toshiyasu Goto, Eriko Ohnishi, Toshiyuki Hiramatsu, Isao Kii, Miyo Yoshida, Teikichi Ikura, Hiroshi Onogi, Hiroshi Shibuya, Takamitsu Hosoya, Nobutoshi Ito, Masatoshi Hagiwara Yasushi Ogawa, Yosuke Nonaka, Toshiyasu Goto, Eriko Ohnishi, Toshiyuki Hiramatsu, Isao Kii, Miyo Yoshida, Teikichi Ikura, Hiroshi Onogi, Hiroshi Shibuya, Takamitsu Hosoya, Nobutoshi Ito, Masatoshi Hagiwara Yasushi Ogawa, Yosuke Nonaka, Toshiyasu Goto, Eriko Ohnishi, Toshiyuki Hiramatsu, Isao Kii, Miyo Yoshida, Teikichi Ikura, Hiroshi Onogi, Hiroshi Shibuya, Takamitsu Hosoya, Nobutoshi Ito, Masatoshi Hagiwara Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A NATURE COMMUNICATIONS, 1, 86 NATURE COMMUNICATIONS, 1, 86 NATURE COMMUNICATIONS, 1, 86 2010/10 英語 研究論文(学術雑誌) 公開
Hidehito Kuroyanagi, Genta Ohno, Hiroaki Sakane, Hiroyuki Maruoka, Masatoshi Hagiwara Hidehito Kuroyanagi, Genta Ohno, Hiroaki Sakane, Hiroyuki Maruoka, Masatoshi Hagiwara Hidehito Kuroyanagi, Genta Ohno, Hiroaki Sakane, Hiroyuki Maruoka, Masatoshi Hagiwara Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans NATURE PROTOCOLS, 5, 9, 1495-1517 NATURE PROTOCOLS, 5, 9, 1495-1517 NATURE PROTOCOLS, 5, 9, 1495-1517 2010/09 英語 研究論文(学術雑誌) 公開
Yuko Karakama, Naoya Sakamoto, Yasuhiro Itsui, Mina Nakagawa, Megumi Tasaka-Fujita, Yuki Nishimura-Sakurai, Sei Kakinuma, Masaya Oooka, Seishin Azuma, Kiichiro Tsuchiya, Hiroshi Onogi, Masatoshi Hagiwara, Mamoru Watanabe Yuko Karakama, Naoya Sakamoto, Yasuhiro Itsui, Mina Nakagawa, Megumi Tasaka-Fujita, Yuki Nishimura-Sakurai, Sei Kakinuma, Masaya Oooka, Seishin Azuma, Kiichiro Tsuchiya, Hiroshi Onogi, Masatoshi Hagiwara, Mamoru Watanabe Yuko Karakama, Naoya Sakamoto, Yasuhiro Itsui, Mina Nakagawa, Megumi Tasaka-Fujita, Yuki Nishimura-Sakurai, Sei Kakinuma, Masaya Oooka, Seishin Azuma, Kiichiro Tsuchiya, Hiroshi Onogi, Masatoshi Hagiwara, Mamoru Watanabe Inhibition of Hepatitis C Virus Replication by a Specific Inhibitor of Serine-Arginine-Rich Protein Kinase Inhibition of Hepatitis C Virus Replication by a Specific Inhibitor of Serine-Arginine-Rich Protein Kinase Inhibition of Hepatitis C Virus Replication by a Specific Inhibitor of Serine-Arginine-Rich Protein Kinase ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54, 8, 3179-3186 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54, 8, 3179-3186 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54, 8, 3179-3186 2010/08 英語 研究論文(学術雑誌) 公開
Akihide Takeuchi, Motoyasu Hosokawa, Takayuki Nojima, Masatoshi Hagiwara Akihide Takeuchi, Motoyasu Hosokawa, Takayuki Nojima, Masatoshi Hagiwara Akihide Takeuchi, Motoyasu Hosokawa, Takayuki Nojima, Masatoshi Hagiwara Splicing Reporter Mice Revealed the Evolutionally Conserved Switching Mechanism of Tissue-Specific Alternative Exon Selection Splicing Reporter Mice Revealed the Evolutionally Conserved Switching Mechanism of Tissue-Specific Alternative Exon Selection Splicing Reporter Mice Revealed the Evolutionally Conserved Switching Mechanism of Tissue-Specific Alternative Exon Selection PLOS ONE, 5, 6, e10946 PLOS ONE, 5, 6, e10946 PLOS ONE, 5, 6, e10946 2010/06 英語 研究論文(学術雑誌) 公開
Dawid G. Nowak, Elianna Mohamed Amin, Emma S. Rennel, Coralie Hoareau-Aveilla, Melissa Gammons, Gopinath Damodoran, Masatoshi Hagiwara, Steven J. Harper, Jeanette Woolard, Michael R. Ladomery, David O. Bates Dawid G. Nowak, Elianna Mohamed Amin, Emma S. Rennel, Coralie Hoareau-Aveilla, Melissa Gammons, Gopinath Damodoran, Masatoshi Hagiwara, Steven J. Harper, Jeanette Woolard, Michael R. Ladomery, David O. Bates Dawid G. Nowak, Elianna Mohamed Amin, Emma S. Rennel, Coralie Hoareau-Aveilla, Melissa Gammons, Gopinath Damodoran, Masatoshi Hagiwara, Steven J. Harper, Jeanette Woolard, Michael R. Ladomery, David O. Bates Regulation of Vascular Endothelial Growth Factor (VEGF) Splicing from Pro-angiogenic to Anti-angiogenic Isoforms A NOVEL THERAPEUTIC STRATEGY FOR ANGIOGENESIS Regulation of Vascular Endothelial Growth Factor (VEGF) Splicing from Pro-angiogenic to Anti-angiogenic Isoforms A NOVEL THERAPEUTIC STRATEGY FOR ANGIOGENESIS Regulation of Vascular Endothelial Growth Factor (VEGF) Splicing from Pro-angiogenic to Anti-angiogenic Isoforms A NOVEL THERAPEUTIC STRATEGY FOR ANGIOGENESIS JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 8, 5532-5540 JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 8, 5532-5540 JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 8, 5532-5540 2010/02 英語 研究論文(学術雑誌) 公開
Isao Kii, Akira Shiraishi, Toshiyuki Hiramatsu, Takeshi Matsushita, Hidehiro Uekusa, Suguru Yoshida, Makoto Yamamoto, Akira Kudo, Masatoshi Hagiwara, Takamitsu Hosoya Isao Kii, Akira Shiraishi, Toshiyuki Hiramatsu, Takeshi Matsushita, Hidehiro Uekusa, Suguru Yoshida, Makoto Yamamoto, Akira Kudo, Masatoshi Hagiwara, Takamitsu Hosoya Isao Kii, Akira Shiraishi, Toshiyuki Hiramatsu, Takeshi Matsushita, Hidehiro Uekusa, Suguru Yoshida, Makoto Yamamoto, Akira Kudo, Masatoshi Hagiwara, Takamitsu Hosoya Strain-promoted double-click reaction for chemical modification of azido-biomolecules Strain-promoted double-click reaction for chemical modification of azido-biomolecules Strain-promoted double-click reaction for chemical modification of azido-biomolecules ORGANIC & BIOMOLECULAR CHEMISTRY, 8, 18, 4051-4055 ORGANIC & BIOMOLECULAR CHEMISTRY, 8, 18, 4051-4055 ORGANIC & BIOMOLECULAR CHEMISTRY, 8, 18, 4051-4055 2010 英語 研究論文(学術雑誌) 公開
Takayuki Nojima, Takako Oshiro-Ideue, Hiroto Nakanoya, Hidenobu Kawamura, Tomomi Morimoto, Yasushi Kawaguchi, Naoyuki Kataoka, Masatoshi Hagiwara Takayuki Nojima, Takako Oshiro-Ideue, Hiroto Nakanoya, Hidenobu Kawamura, Tomomi Morimoto, Yasushi Kawaguchi, Naoyuki Kataoka, Masatoshi Hagiwara Takayuki Nojima, Takako Oshiro-Ideue, Hiroto Nakanoya, Hidenobu Kawamura, Tomomi Morimoto, Yasushi Kawaguchi, Naoyuki Kataoka, Masatoshi Hagiwara Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing NUCLEIC ACIDS RESEARCH, 37, 19, 6515-6527 NUCLEIC ACIDS RESEARCH, 37, 19, 6515-6527 NUCLEIC ACIDS RESEARCH, 37, 19, 6515-6527 2009/10 英語 研究論文(学術雑誌) 公開
Jiang K, Patel NA, Watson JE, Apostolatos H, Kleiman E, Hanson O, Hagiwara M, Cooper DR Jiang K, Patel NA, Watson JE, Apostolatos H, Kleiman E, Hanson O, Hagiwara M, Cooper DR Jiang K, Patel NA, Watson JE, Apostolatos H, Kleiman E, Hanson O, Hagiwara M, Cooper DR Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCβII mRNA. Endocrinology, 150, 2087-2097. Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCβII mRNA. Endocrinology, 150, 2087-2097. Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCbetaII messenger ribonucleic acid. Endocrinology, 150, 5, 2087-2097 Endocrinology, 150, 5, 2087-2097 Endocrinology, 150, 5, 2087-2097 2009/05 日本語 研究論文(学術雑誌) 公開
Jun-ichiro Yomoda, Michiko Muraki, Naoyuki Kataoka, Takamitsu Hosoya, Masaaki Suzuki, Masatoshi Hagiwara, Hiroshi Kimura Jun-ichiro Yomoda, Michiko Muraki, Naoyuki Kataoka, Takamitsu Hosoya, Masaaki Suzuki, Masatoshi Hagiwara, Hiroshi Kimura Jun-ichiro Yomoda, Michiko Muraki, Naoyuki Kataoka, Takamitsu Hosoya, Masaaki Suzuki, Masatoshi Hagiwara, Hiroshi Kimura Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A GENES TO CELLS, 13, 3, 233-244 GENES TO CELLS, 13, 3, 233-244 GENES TO CELLS, 13, 3, 233-244 2008/03 英語 研究論文(学術雑誌) 公開
Genta Ohno, Masatoshi Hagiwara, Hidehito Kuroyanagi Genta Ohno, Masatoshi Hagiwara, Hidehito Kuroyanagi Genta Ohno, Masatoshi Hagiwara, Hidehito Kuroyanagi STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo GENES & DEVELOPMENT, 22, 3, 360-374 GENES & DEVELOPMENT, 22, 3, 360-374 GENES & DEVELOPMENT, 22, 3, 360-374 2008/02 英語 研究論文(学術雑誌) 公開
Hidehito Kuroyanagi, Genta Ohno, Shohel Mitani, Masatoshi Hagiwara Hidehito Kuroyanagi, Genta Ohno, Shohel Mitani, Masatoshi Hagiwara Hidehito Kuroyanagi, Genta Ohno, Shohel Mitani, Masatoshi Hagiwara The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo MOLECULAR AND CELLULAR BIOLOGY, 27, 24, 8612-8621 MOLECULAR AND CELLULAR BIOLOGY, 27, 24, 8612-8621 MOLECULAR AND CELLULAR BIOLOGY, 27, 24, 8612-8621 2007/12 英語 研究論文(学術雑誌) 公開
Daisuke Kaida, Hajime Motoyoshi, Etsu Tashiro, Takayuki Nojima, Masatoshi Hagiwara, Ken Ishigami, Hidenori Watanabe, Takeshi Kitahara, Tatsuhiko Yoshida, Hidenori Nakajima, Tokio Tani, Sueharu Horinouchi, Minoru Yoshida Daisuke Kaida, Hajime Motoyoshi, Etsu Tashiro, Takayuki Nojima, Masatoshi Hagiwara, Ken Ishigami, Hidenori Watanabe, Takeshi Kitahara, Tatsuhiko Yoshida, Hidenori Nakajima, Tokio Tani, Sueharu Horinouchi, Minoru Yoshida Daisuke Kaida, Hajime Motoyoshi, Etsu Tashiro, Takayuki Nojima, Masatoshi Hagiwara, Ken Ishigami, Hidenori Watanabe, Takeshi Kitahara, Tatsuhiko Yoshida, Hidenori Nakajima, Tokio Tani, Sueharu Horinouchi, Minoru Yoshida Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA NATURE CHEMICAL BIOLOGY, 3, 9, 576-583 NATURE CHEMICAL BIOLOGY, 3, 9, 576-583 NATURE CHEMICAL BIOLOGY, 3, 9, 576-583 2007/09 英語 研究論文(学術雑誌) 公開
Takashi Ideue, Yasnory T. F. Sasaki, Masatoshi Hagiwara, Tetsuro Hirose Takashi Ideue, Yasnory T. F. Sasaki, Masatoshi Hagiwara, Tetsuro Hirose Takashi Ideue, Yasnory T. F. Sasaki, Masatoshi Hagiwara, Tetsuro Hirose Introns play an essential role in splicing-dependent formation of the exon junction complex Introns play an essential role in splicing-dependent formation of the exon junction complex Introns play an essential role in splicing-dependent formation of the exon junction complex GENES & DEVELOPMENT, 21, 16, 1993-1998 GENES & DEVELOPMENT, 21, 16, 1993-1998 GENES & DEVELOPMENT, 21, 16, 1993-1998 2007/08 英語 研究論文(学術雑誌) 公開
Takayuki Nojima, Tetsuro Hirose, Hiroshi Kimura, Masatoshi Hagiwara Takayuki Nojima, Tetsuro Hirose, Hiroshi Kimura, Masatoshi Hagiwara Takayuki Nojima, Tetsuro Hirose, Hiroshi Kimura, Masatoshi Hagiwara The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export JOURNAL OF BIOLOGICAL CHEMISTRY, 282, 21, 15645-15651 JOURNAL OF BIOLOGICAL CHEMISTRY, 282, 21, 15645-15651 JOURNAL OF BIOLOGICAL CHEMISTRY, 282, 21, 15645-15651 2007/05 英語 研究論文(学術雑誌) 公開
Tomomi Aida, Atsuo Konishi, Masatoshi Hagiwara, Kazunori Hashimoto Tomomi Aida, Atsuo Konishi, Masatoshi Hagiwara, Kazunori Hashimoto Tomomi Aida, Atsuo Konishi, Masatoshi Hagiwara, Kazunori Hashimoto Shortened life spans of biotech pioneer patents in Japan: a lesson from the DNA chip Shortened life spans of biotech pioneer patents in Japan: a lesson from the DNA chip Shortened life spans of biotech pioneer patents in Japan: a lesson from the DNA chip NATURE BIOTECHNOLOGY, 25, 5, 533-535 NATURE BIOTECHNOLOGY, 25, 5, 533-535 NATURE BIOTECHNOLOGY, 25, 5, 533-535 2007/05 英語 公開
Hidehito Kuroyanagi, Tetsuo Kobayashi, Shohei Mitani, Masatoshi Hagiwara Hidehito Kuroyanagi, Tetsuo Kobayashi, Shohei Mitani, Masatoshi Hagiwara Hidehito Kuroyanagi, Tetsuo Kobayashi, Shohei Mitani, Masatoshi Hagiwara Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo NATURE METHODS, 3, 11, 909-915 NATURE METHODS, 3, 11, 909-915 NATURE METHODS, 3, 11, 909-915 2006/11 英語 研究論文(学術雑誌) 公開
Hiroshi Kimura, Nanako Takizawa, Eric Allemand, Tetsuya Hori, Francisco J. Iborra, Naohito Nozaki, Michiko Muraki, Masatoshi Hagiwara, Adrian R. Krainer, Tatsuo Fukagawa, Katsuya Okawa Hiroshi Kimura, Nanako Takizawa, Eric Allemand, Tetsuya Hori, Francisco J. Iborra, Naohito Nozaki, Michiko Muraki, Masatoshi Hagiwara, Adrian R. Krainer, Tatsuo Fukagawa, Katsuya Okawa Hiroshi Kimura, Nanako Takizawa, Eric Allemand, Tetsuya Hori, Francisco J. Iborra, Naohito Nozaki, Michiko Muraki, Masatoshi Hagiwara, Adrian R. Krainer, Tatsuo Fukagawa, Katsuya Okawa A novel histone exchange factor, protein phosphatase 2C gamma mediates the exchange and dephosphorylation of H2A-H2B A novel histone exchange factor, protein phosphatase 2C gamma mediates the exchange and dephosphorylation of H2A-H2B A novel histone exchange factor, protein phosphatase 2C gamma mediates the exchange and dephosphorylation of H2A-H2B JOURNAL OF CELL BIOLOGY, 175, 3, 389-400 JOURNAL OF CELL BIOLOGY, 175, 3, 389-400 JOURNAL OF CELL BIOLOGY, 175, 3, 389-400 2006/11 英語 研究論文(学術雑誌) 公開
Kazuhiro Wada, Jason T. Howard, Patrick McConnell, Osceola Whitney, Thierry Lints, Miriam V. Rivas, Haruhito Horita, Michael A. Patterson, Stephanie A. White, Constance Scharff, Sebastian Haesler, Shengli Zhao, Hironobu Sakaguchi, Masatoshi Hagiwara, Toshiyuki Shiraki, Tomoko Hirozane-Kishikawa, Pate Skene, Yoshihide Hayashizaki, Piero Carninci, Erich D. Jarvis Kazuhiro Wada, Jason T. Howard, Patrick McConnell, Osceola Whitney, Thierry Lints, Miriam V. Rivas, Haruhito Horita, Michael A. Patterson, Stephanie A. White, Constance Scharff, Sebastian Haesler, Shengli Zhao, Hironobu Sakaguchi, Masatoshi Hagiwara, Toshiyuki Shiraki, Tomoko Hirozane-Kishikawa, Pate Skene, Yoshihide Hayashizaki, Piero Carninci, Erich D. Jarvis Kazuhiro Wada, Jason T. Howard, Patrick McConnell, Osceola Whitney, Thierry Lints, Miriam V. Rivas, Haruhito Horita, Michael A. Patterson, Stephanie A. White, Constance Scharff, Sebastian Haesler, Shengli Zhao, Hironobu Sakaguchi, Masatoshi Hagiwara, Toshiyuki Shiraki, Tomoko Hirozane-Kishikawa, Pate Skene, Yoshihide Hayashizaki, Piero Carninci, Erich D. Jarvis A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103, 41, 15212-15217 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103, 41, 15212-15217 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103, 41, 15212-15217 2006/10 英語 研究論文(学術雑誌) 公開
Tetsuro Hirose, Takashi Ideue, Misato Nagai, Masatoshi Hagiwara, Mei-Di Shu, Joan A. Steitz Tetsuro Hirose, Takashi Ideue, Misato Nagai, Masatoshi Hagiwara, Mei-Di Shu, Joan A. Steitz Tetsuro Hirose, Takashi Ideue, Misato Nagai, Masatoshi Hagiwara, Mei-Di Shu, Joan A. Steitz A spliceosomal intron binding protein, IBP160, links position-dependent assembly of intron-encoded box C/D snoRNP to pre-mRNA splicing A spliceosomal intron binding protein, IBP160, links position-dependent assembly of intron-encoded box C/D snoRNP to pre-mRNA splicing A spliceosomal intron binding protein, IBP160, links position-dependent assembly of intron-encoded box C/D snoRNP to pre-mRNA splicing MOLECULAR CELL, 23, 5, 673-684 MOLECULAR CELL, 23, 5, 673-684 MOLECULAR CELL, 23, 5, 673-684 2006/09 英語 研究論文(学術雑誌) 公開
Takeshi Fukuhara, Takamitsu Hosoya, Saki Shimizu, Kengo Sumi, Takako Oshiro, Yoshiyuki Yoshinaka, Masaaki Suzuki, Naoki Yamamoto, Leonore A. Herzenberg, Leonard A. Herzenberg, Masatoshi Hagiwara Takeshi Fukuhara, Takamitsu Hosoya, Saki Shimizu, Kengo Sumi, Takako Oshiro, Yoshiyuki Yoshinaka, Masaaki Suzuki, Naoki Yamamoto, Leonore A. Herzenberg, Leonard A. Herzenberg, Masatoshi Hagiwara Takeshi Fukuhara, Takamitsu Hosoya, Saki Shimizu, Kengo Sumi, Takako Oshiro, Yoshiyuki Yoshinaka, Masaaki Suzuki, Naoki Yamamoto, Leonore A. Herzenberg, Leonard A. Herzenberg, Masatoshi Hagiwara Utilization of host SR protein kinases and RNA-splicing machinery during viral replication Utilization of host SR protein kinases and RNA-splicing machinery during viral replication Utilization of host SR protein kinases and RNA-splicing machinery during viral replication PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103, 30, 11329-11333 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103, 30, 11329-11333 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103, 30, 11329-11333 2006/07 英語 研究論文(学術雑誌) 公開
N Ohki, M Hagiwara N Ohki, M Hagiwara N Ohki, M Hagiwara Bio-Object, a stochastic simulator for post-transcriptional regulation Bio-Object, a stochastic simulator for post-transcriptional regulation Bio-Object, a stochastic simulator for post-transcriptional regulation BIOINFORMATICS, 21, 10, 2478-2487 BIOINFORMATICS, 21, 10, 2478-2487 BIOINFORMATICS, 21, 10, 2478-2487 2005/05 英語 研究論文(学術雑誌) 公開
K Wada, H Sakaguchi, ED Jarvis, M Hagiwara K Wada, H Sakaguchi, ED Jarvis, M Hagiwara K Wada, H Sakaguchi, ED Jarvis, M Hagiwara Differential expression of glutamate receptors in avian neural pathways for learned vocalization Differential expression of glutamate receptors in avian neural pathways for learned vocalization Differential expression of glutamate receptors in avian neural pathways for learned vocalization JOURNAL OF COMPARATIVE NEUROLOGY, 476, 1, 44-64 JOURNAL OF COMPARATIVE NEUROLOGY, 476, 1, 44-64 JOURNAL OF COMPARATIVE NEUROLOGY, 476, 1, 44-64 2004/08 英語 公開
M Takano, Y Koyama, H Ito, S Hoshino, H Onogi, M Hagiwara, K Furukawa, T Horigome M Takano, Y Koyama, H Ito, S Hoshino, H Onogi, M Hagiwara, K Furukawa, T Horigome M Takano, Y Koyama, H Ito, S Hoshino, H Onogi, M Hagiwara, K Furukawa, T Horigome Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 13, 13265-13271 JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 13, 13265-13271 JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 13, 13265-13271 2004/03 英語 研究論文(学術雑誌) 公開
K Inoue, T Zama, T Kamimoto, R Aoki, Y Ikeda, H Kimura, M Hagiwara K Inoue, T Zama, T Kamimoto, R Aoki, Y Ikeda, H Kimura, M Hagiwara K Inoue, T Zama, T Kamimoto, R Aoki, Y Ikeda, H Kimura, M Hagiwara TNF alpha-induced ATF3 expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells TNF alpha-induced ATF3 expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells TNF alpha-induced ATF3 expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells GENES TO CELLS, 9, 1, 59-70 GENES TO CELLS, 9, 1, 59-70 GENES TO CELLS, 9, 1, 59-70 2004/01 英語 研究論文(学術雑誌) 公開
H Suzuki, JH Wu, K Hossain, T Ohhata, J Du, AA Akhand, A Hayakawa, H Kimura, M Hagiwara, Nakashima, I H Suzuki, JH Wu, K Hossain, T Ohhata, J Du, AA Akhand, A Hayakawa, H Kimura, M Hagiwara, Nakashima, I H Suzuki, JH Wu, K Hossain, T Ohhata, J Du, AA Akhand, A Hayakawa, H Kimura, M Hagiwara, Nakashima, I Involvement of MKK6 in TCRa beta(int)CD69(lo): a target population for apoptotic cell death in thymocytes Involvement of MKK6 in TCRa beta(int)CD69(lo): a target population for apoptotic cell death in thymocytes Involvement of MKK6 in TCRa beta(int)CD69(lo): a target population for apoptotic cell death in thymocytes FASEB JOURNAL, 17, 9, 1538-+ FASEB JOURNAL, 17, 9, 1538-+ FASEB JOURNAL, 17, 9, 1538-+ 2003/06 英語 研究論文(学術雑誌) 公開
H Umehara, Y Nishii, M Morishima, Y Kakehi, N Kioka, T Amachi, J Koizumi, M Hagiwara, K Ueda H Umehara, Y Nishii, M Morishima, Y Kakehi, N Kioka, T Amachi, J Koizumi, M Hagiwara, K Ueda H Umehara, Y Nishii, M Morishima, Y Kakehi, N Kioka, T Amachi, J Koizumi, M Hagiwara, K Ueda Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/]Luc7A Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/]Luc7A Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/]Luc7A BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 301, 2, 324-329 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 301, 2, 324-329 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 301, 2, 324-329 2003/02 英語 研究論文(学術雑誌) 公開
T Suzuki, T Yamakuni, M Hagiwara, H Ichinose T Suzuki, T Yamakuni, M Hagiwara, H Ichinose T Suzuki, T Yamakuni, M Hagiwara, H Ichinose Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 43, 40768-40774 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 43, 40768-40774 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 43, 40768-40774 2002/10 英語 研究論文(学術雑誌) 公開
Wada K, Inoue K, Hagiwara M Wada K, Inoue K, Hagiwara M Wada K, Inoue K, Hagiwara M Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy. Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy. Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy. Biochimica et biophysica acta, 1591, 1-3, 1-10 Biochimica et biophysica acta, 1591, 1-3, 1-10 Biochimica et biophysica acta, 1591, 1-3, 1-10 2002/08 公開
T Zama, R Aoki, T Kamimoto, K Inoue, Y Ikeda, M Hagiwara T Zama, R Aoki, T Kamimoto, K Inoue, Y Ikeda, M Hagiwara T Zama, R Aoki, T Kamimoto, K Inoue, Y Ikeda, M Hagiwara A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 26, 23909-23918 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 26, 23909-23918 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 26, 23909-23918 2002/06 英語 研究論文(学術雑誌) 公開
T Zama, R Aoki, T Kamimoto, K Inoue, Y Ikeda, M Hagiwara T Zama, R Aoki, T Kamimoto, K Inoue, Y Ikeda, M Hagiwara T Zama, R Aoki, T Kamimoto, K Inoue, Y Ikeda, M Hagiwara Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 26, 23919-23926 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 26, 23919-23926 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 26, 23919-23926 2002/06 英語 研究論文(学術雑誌) 公開

  • <<
  • >>
  • 表示
タイトル言語:
Misc
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Arbones ML, Thomazeau A, Nakano-Kobayashi A, Hagiwara M, Delabar JM Arbones ML, Thomazeau A, Nakano-Kobayashi A, Hagiwara M, Delabar JM Arbones ML, Thomazeau A, Nakano-Kobayashi A, Hagiwara M, Delabar JM DYRK1A and cognition: A lifelong relationship. DYRK1A and cognition: A lifelong relationship. DYRK1A and cognition: A lifelong relationship. Pharmacology & therapeutics Pharmacology & therapeutics Pharmacology & therapeutics 2018/09 公開
Kenji Ohe, Masatoshi Hagiwara Kenji Ohe, Masatoshi Hagiwara Kenji Ohe, Masatoshi Hagiwara Modulation of Alternative Splicing with Chemical Compounds in New Therapeutics for Human Diseases Modulation of Alternative Splicing with Chemical Compounds in New Therapeutics for Human Diseases Modulation of Alternative Splicing with Chemical Compounds in New Therapeutics for Human Diseases ACS CHEMICAL BIOLOGY, 10, 4, 914-924 ACS CHEMICAL BIOLOGY, 10, 4, 914-924 ACS CHEMICAL BIOLOGY, 10, 4, 914-924 2015/04 英語 書評、文献紹介等 公開
Yasushi Ogawa, Masatoshi Hagiwara Yasushi Ogawa, Masatoshi Hagiwara Yasushi Ogawa, Masatoshi Hagiwara Challenges to congenital genetic disorders with "RNA-targeting" chemical compounds Challenges to congenital genetic disorders with "RNA-targeting" chemical compounds Challenges to congenital genetic disorders with "RNA-targeting" chemical compounds PHARMACOLOGY & THERAPEUTICS, 134, 3, 298-305 PHARMACOLOGY & THERAPEUTICS, 134, 3, 298-305 PHARMACOLOGY & THERAPEUTICS, 134, 3, 298-305 2012/06 英語 書評、文献紹介等 公開
Hagiwara M Hagiwara M Hagiwara M [Overview of chemical biology]. [Overview of chemical biology]. [Overview of chemical biology]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 132, 1, 4-6 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 132, 1, 4-6 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 132, 1, 4-6 2008/07 公開
Hagiwara M Hagiwara M Hagiwara M [Development of protein kinase inhibitors and their applications for chemical biology]. [Development of protein kinase inhibitors and their applications for chemical biology]. [Development of protein kinase inhibitors and their applications for chemical biology]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 132, 1, 22-25 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 132, 1, 22-25 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 132, 1, 22-25 2008/07 公開
Hagiwara M, Usuki H Hagiwara M, Usuki H Hagiwara M, Usuki H [Kinase inhibitors]. [Kinase inhibitors]. [Kinase inhibitors]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1708-1712 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1708-1712 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1708-1712 2007/10 公開
Masatoshi Hagiwara, Takayuki Nojima Masatoshi Hagiwara, Takayuki Nojima Masatoshi Hagiwara, Takayuki Nojima Cross-talks between transcription and post-transcriptional events within a 'mRNA factory' Cross-talks between transcription and post-transcriptional events within a 'mRNA factory' Cross-talks between transcription and post-transcriptional events within a 'mRNA factory' JOURNAL OF BIOCHEMISTRY, 142, 1, 11-15 JOURNAL OF BIOCHEMISTRY, 142, 1, 11-15 JOURNAL OF BIOCHEMISTRY, 142, 1, 11-15 2007/07 英語 書評、文献紹介等 公開
Hagiwara M Hagiwara M Hagiwara M Alternative splicing: a new drug target of the post-genome era. Alternative splicing: a new drug target of the post-genome era. Alternative splicing: a new drug target of the post-genome era. Biochimica et biophysica acta, 1754, 1-2, 324-331 Biochimica et biophysica acta, 1754, 1-2, 324-331 Biochimica et biophysica acta, 1754, 1-2, 324-331 2005/12 公開
M Muraki, B Ohkawara, T Hosoya, H Onogi, J Koizumi, T Koizumi, K Sumi, Y Jun-ichiro, MV Murray, H Kimura, K Furuichi, H Shibuya, AR Krainer, M Suzuki, M Hagiwara M Muraki, B Ohkawara, T Hosoya, H Onogi, J Koizumi, T Koizumi, K Sumi, Y Jun-ichiro, MV Murray, H Kimura, K Furuichi, H Shibuya, AR Krainer, M Suzuki, M Hagiwara M Muraki, B Ohkawara, T Hosoya, H Onogi, J Koizumi, T Koizumi, K Sumi, Y Jun-ichiro, MV Murray, H Kimura, K Furuichi, H Shibuya, AR Krainer, M Suzuki, M Hagiwara Manipulation of alternative splicing by a newly developed inhibitor of Clks Manipulation of alternative splicing by a newly developed inhibitor of Clks Manipulation of alternative splicing by a newly developed inhibitor of Clks JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 23, 24246-24254 JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 23, 24246-24254 JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 23, 24246-24254 2004/06 英語 公開
R Katsu, H Onogi, K Wada, Y Kawaguchi, M Hagiwara R Katsu, H Onogi, K Wada, Y Kawaguchi, M Hagiwara R Katsu, H Onogi, K Wada, Y Kawaguchi, M Hagiwara Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 46, 44220-44228 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 46, 44220-44228 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 46, 44220-44228 2002/11 英語 公開
Y Kimura, EE Corcoran, K Eto, K Gengyo-Ando, M Muramatsu, R Kobayashi, JH Freedman, S Mitani, M Hagiwara, AR Means, H Tokumitsu Y Kimura, EE Corcoran, K Eto, K Gengyo-Ando, M Muramatsu, R Kobayashi, JH Freedman, S Mitani, M Hagiwara, AR Means, H Tokumitsu Y Kimura, EE Corcoran, K Eto, K Gengyo-Ando, M Muramatsu, R Kobayashi, JH Freedman, S Mitani, M Hagiwara, AR Means, H Tokumitsu A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans EMBO REPORTS, 3, 10, 962-966 EMBO REPORTS, 3, 10, 962-966 EMBO REPORTS, 3, 10, 962-966 2002/10 英語 公開
Y Kimura, EE Corcoran, K Eto, K Gengyo-Ando, M Muramatsu, R Kobayashi, JH Freedman, S Mitani, M Hagiwara, AR Means, H Tokumitsu Y Kimura, EE Corcoran, K Eto, K Gengyo-Ando, M Muramatsu, R Kobayashi, JH Freedman, S Mitani, M Hagiwara, AR Means, H Tokumitsu Y Kimura, EE Corcoran, K Eto, K Gengyo-Ando, M Muramatsu, R Kobayashi, JH Freedman, S Mitani, M Hagiwara, AR Means, H Tokumitsu A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans EMBO REPORTS, 3, 10, 962-966 EMBO REPORTS, 3, 10, 962-966 EMBO REPORTS, 3, 10, 962-966 2002/10 英語 公開
Y Muro, T Kamimoto, Y Tomita, M Hagiwara Y Muro, T Kamimoto, Y Tomita, M Hagiwara Y Muro, T Kamimoto, Y Tomita, M Hagiwara Spectrum of autoantibodies against a dynamin-related protein, dymple Spectrum of autoantibodies against a dynamin-related protein, dymple Spectrum of autoantibodies against a dynamin-related protein, dymple ARTHRITIS AND RHEUMATISM, 43, 7, 1516-1519 ARTHRITIS AND RHEUMATISM, 43, 7, 1516-1519 ARTHRITIS AND RHEUMATISM, 43, 7, 1516-1519 2000/07 英語 公開
NAGAI Y, MIYAZAKI M, AOKI R, ZAMA T, INOUYE S, HIROSE K, IINO M, HAGIWARA M NAGAI Y, MIYAZAKI M, AOKI R, ZAMA T, INOUYE S, HIROSE K, IINO M, HAGIWARA M A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo. A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo. Nat. Biotechnol, 18, 3, 313-316 Nat. Biotechnol, 18, 3, 313-316 , 18, 3, 313-316 2000 公開
Jiro Usukura, Yuji Nishizawa, Atsushi Shimomura, Kazuto Kobayashi, Toshiharu Nagatsu, Masatoshi Hagiwara Jiro Usukura, Yuji Nishizawa, Atsushi Shimomura, Kazuto Kobayashi, Toshiharu Nagatsu, Masatoshi Hagiwara Jiro Usukura, Yuji Nishizawa, Atsushi Shimomura, Kazuto Kobayashi, Toshiharu Nagatsu, Masatoshi Hagiwara Direct imaging of phosphorylation-dependent conformational change and DNA binding of CREB by electron microscopy Direct imaging of phosphorylation-dependent conformational change and DNA binding of CREB by electron microscopy Direct imaging of phosphorylation-dependent conformational change and DNA binding of CREB by electron microscopy Genes to Cells, 5, 6, 515-522 Genes to Cells, 5, 6, 515-522 Genes to Cells, 5, 6, 515-522 2000 英語 公開
Novel RING finger proteins, Air1p and 2p interact with Hmt1p and inhibit the arginine methylation of Np13p. Novel RING finger proteins, Air1p and 2p interact with Hmt1p and inhibit the arginine methylation of Np13p. Novel RING finger proteins, Air1p and 2p interact with Hmt1p and inhibit the arginine methylation of Np13p. J.Biol. Chem., in press J.Biol. Chem., in press J.Biol. Chem., in press 2000 公開
SPK-1 a C. elegans SR proteins kinase homologue, is essential for embryogenesis and required for germline development. SPK-1 a C. elegans SR proteins kinase homologue, is essential for embryogenesis and required for germline development. SPK-1 a C. elegans SR proteins kinase homologue, is essential for embryogenesis and required for germline development. Mech. Dev., in press Mech. Dev., in press Mech. Dev., in press 2000 公開
A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo. A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo. A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo. Nat. Biotechnol, 18, 3, 313-316 Nat. Biotechnol, 18, 3, 313-316 Nat. Biotechnol, 18, 3, 313-316 2000 公開
H Sakaguchi, K Wada, M Maekawa, T Watsuji, M Hagiwara H Sakaguchi, K Wada, M Maekawa, T Watsuji, M Hagiwara H Sakaguchi, K Wada, M Maekawa, T Watsuji, M Hagiwara Song-induced phosphorylation of cAMP response element-binding protein in the songbird brain Song-induced phosphorylation of cAMP response element-binding protein in the songbird brain Song-induced phosphorylation of cAMP response element-binding protein in the songbird brain JOURNAL OF NEUROSCIENCE, 19, 10, 3973-3981 JOURNAL OF NEUROSCIENCE, 19, 10, 3973-3981 JOURNAL OF NEUROSCIENCE, 19, 10, 3973-3981 1999/05 英語 公開
H Sakaguchi, K Wada, M Maekawa, T Watsuji, M Hagiwara H Sakaguchi, K Wada, M Maekawa, T Watsuji, M Hagiwara H Sakaguchi, K Wada, M Maekawa, T Watsuji, M Hagiwara Song-induced phosphorylation of cAMP response element-binding protein in the songbird brain Song-induced phosphorylation of cAMP response element-binding protein in the songbird brain Song-induced phosphorylation of cAMP response element-binding protein in the songbird brain JOURNAL OF NEUROSCIENCE, 19, 10, 3973-3981 JOURNAL OF NEUROSCIENCE, 19, 10, 3973-3981 JOURNAL OF NEUROSCIENCE, 19, 10, 3973-3981 1999/05 英語 公開
KOIZUMI J, OKAMOTO Y, ONOGI H, MAYEDA A, KRAINER A R, HAGIWARA M KOIZUMI J, OKAMOTO Y, ONOGI H, MAYEDA A, KRAINER A R, HAGIWARA M The subcellular localization of SF2/ASF is regulated by the direct interaction with SR protein kinases (SRPKs) The subcellular localization of SF2/ASF is regulated by the direct interaction with SR protein kinases (SRPKs) J. Biol. Chem., 274, 16, 11125-11131 J. Biol. Chem., 274, 16, 11125-11131 , 274, 16, 11125-11131 1999 公開
The subcellular localization of SF2/ASF is regulated by the direct interaction with SR protein kinases (SRPKs). The subcellular localization of SF2/ASF is regulated by the direct interaction with SR protein kinases (SRPKs). The subcellular localization of SF2/ASF is regulated by the direct interaction with SR protein kinases (SRPKs). J. Biol. Chem., 274, 16, 11125-11131 J. Biol. Chem., 274, 16, 11125-11131 J. Biol. Chem., 274, 16, 11125-11131 1999 公開
A Shimomura, Y Okamoto, Y Hirata, M Kobayashi, G Kawakami, K Kiuchi, T Wakabayashi, M Hagiwara A Shimomura, Y Okamoto, Y Hirata, M Kobayashi, G Kawakami, K Kiuchi, T Wakabayashi, M Hagiwara A Shimomura, Y Okamoto, Y Hirata, M Kobayashi, G Kawakami, K Kiuchi, T Wakabayashi, M Hagiwara Dominant negative ATF1 blocks cyclic AMP-induced neurite outgrowth in PC12D cells Dominant negative ATF1 blocks cyclic AMP-induced neurite outgrowth in PC12D cells Dominant negative ATF1 blocks cyclic AMP-induced neurite outgrowth in PC12D cells JOURNAL OF NEUROCHEMISTRY, 70, 3, 1029-1034 JOURNAL OF NEUROCHEMISTRY, 70, 3, 1029-1034 JOURNAL OF NEUROCHEMISTRY, 70, 3, 1029-1034 1998/03 英語 公開
Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. Biochem. Biophys. Res. Commun., 242, 2, 357-364 Biochem. Biophys. Res. Commun., 242, 2, 357-364 Biochem. Biophys. Res. Commun., 242, 2, 357-364 1998 公開
Dymple, a Novel Dynamin-like High Molecular Weight GTPase Lacking a Proline-rich Carboxyl-terminal Domain in Mammalian Cells. Dymple, a Novel Dynamin-like High Molecular Weight GTPase Lacking a Proline-rich Carboxyl-terminal Domain in Mammalian Cells. Dymple, a Novel Dynamin-like High Molecular Weight GTPase Lacking a Proline-rich Carboxyl-terminal Domain in Mammalian Cells. J.Biol. Chem., 273, 2, 1044-1051 J.Biol. Chem., 273, 2, 1044-1051 J.Biol. Chem., 273, 2, 1044-1051 1998 公開
Characterization of a Serum Response Factor-Like Protein in Saccharomyces cerevisiae, Rlml, Which Has Transcriptional Activity Regulated by the Mpli(Slt2)Mitogen-Activated Protein Kinase Pathway Characterization of a Serum Response Factor-Like Protein in Saccharomyces cerevisiae, Rlml, Which Has Transcriptional Activity Regulated by the Mpli(Slt2)Mitogen-Activated Protein Kinase Pathway Mol. Cell. Biol., 17, 5, 2615-2623 Mol. Cell. Biol., 17, 5, 2615-2623 , 17, 5, 2615-2623 1997 公開
Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na, K-ATPase al subunit gene promotor. Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na, K-ATPase al subunit gene promotor. Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na, K-ATPase al subunit gene promotor. Nucleic Acid Research., 25, 4, 877-882 Nucleic Acid Research., 25, 4, 877-882 Nucleic Acid Research., 25, 4, 877-882 1997 公開
Characterization of a Serum Response Factor-Like Protein in Saccharomyces cerevisiae, Rlml, Which Has Transcriptional Activity Regulated by the Mpli(Slt2)Mitogen-Activated Protein Kinase Pathway. Characterization of a Serum Response Factor-Like Protein in Saccharomyces cerevisiae, Rlml, Which Has Transcriptional Activity Regulated by the Mpli(Slt2)Mitogen-Activated Protein Kinase Pathway. Characterization of a Serum Response Factor-Like Protein in Saccharomyces cerevisiae, Rlml, Which Has Transcriptional Activity Regulated by the Mpli(Slt2)Mitogen-Activated Protein Kinase Pathway. Mol. Cell. Biol., 17, 5, 2615-2623 Mol. Cell. Biol., 17, 5, 2615-2623 Mol. Cell. Biol., 17, 5, 2615-2623 1997 公開
H Okada, K Miyamura, T Itoh, M Hagiwara, T Wakabayashi, M Mizuno, P Colosi, G Kurtzman, J Yoshida H Okada, K Miyamura, T Itoh, M Hagiwara, T Wakabayashi, M Mizuno, P Colosi, G Kurtzman, J Yoshida H Okada, K Miyamura, T Itoh, M Hagiwara, T Wakabayashi, M Mizuno, P Colosi, G Kurtzman, J Yoshida Gene therapy against an experimental glioma using adeno-associated virus vectors Gene therapy against an experimental glioma using adeno-associated virus vectors Gene therapy against an experimental glioma using adeno-associated virus vectors GENE THERAPY, 3, 11, 957-964 GENE THERAPY, 3, 11, 957-964 GENE THERAPY, 3, 11, 957-964 1996/11 英語 公開
Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of MAPKK6 by osmotic shock, tumor Necrosis factor-a and H202. Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of MAPKK6 by osmotic shock, tumor Necrosis factor-a and H202. Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of MAPKK6 by osmotic shock, tumor Necrosis factor-a and H202. J. Biol. Chem., 271, 17957-17960 J. Biol. Chem., 271, 17957-17960 J. Biol. Chem., 271, 17957-17960 1996 公開
Calmodulin-dependent protein kinase II potentiates transcriptional activation through ATF1, but not CREB. Calmodulin-dependent protein kinase II potentiates transcriptional activation through ATF1, but not CREB. Calmodulin-dependent protein kinase II potentiates transcriptional activation through ATF1, but not CREB. J. Biol. Chem., 271, 30, 17957-17960 J. Biol. Chem., 271, 30, 17957-17960 J. Biol. Chem., 271, 30, 17957-17960 1996 公開
A novel kinase cascade mediated by MAPKK6 and MKK3. A novel kinase cascade mediated by MAPKK6 and MKK3. A novel kinase cascade mediated by MAPKK6 and MKK3. J. Biol. Chem., 271, 13675-13679 J. Biol. Chem., 271, 13675-13679 J. Biol. Chem., 271, 13675-13679 1996 公開
K YOSHIDA, J IMAKI, H MATSUDA, M HAGIWARA K YOSHIDA, J IMAKI, H MATSUDA, M HAGIWARA K YOSHIDA, J IMAKI, H MATSUDA, M HAGIWARA LIGHT-INDUCED CREB PHOSPHORYLATION AND GENE-EXPRESSION IN RAT RETINAL CELLS LIGHT-INDUCED CREB PHOSPHORYLATION AND GENE-EXPRESSION IN RAT RETINAL CELLS LIGHT-INDUCED CREB PHOSPHORYLATION AND GENE-EXPRESSION IN RAT RETINAL CELLS JOURNAL OF NEUROCHEMISTRY, 65, 4, 1499-1504 JOURNAL OF NEUROCHEMISTRY, 65, 4, 1499-1504 JOURNAL OF NEUROCHEMISTRY, 65, 4, 1499-1504 1995/10 英語 公開
Recombinant cyclic AMP response element binding protein(CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei. Recombinant cyclic AMP response element binding protein(CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei. Recombinant cyclic AMP response element binding protein(CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei. J. Biol. Chem., 269, 7623-30 J. Biol. Chem., 269, 7623-30 J. Biol. Chem., 269, 7623-30 1994 公開
JC CHRIVIA, RPS KWOK, N LAMB, M HAGIWARA, MR MONTMINY, RH GOODMAN JC CHRIVIA, RPS KWOK, N LAMB, M HAGIWARA, MR MONTMINY, RH GOODMAN JC CHRIVIA, RPS KWOK, N LAMB, M HAGIWARA, MR MONTMINY, RH GOODMAN PHOSPHORYLATED CREB BINDS SPECIFICALLY TO THE NUCLEAR-PROTEIN CBP PHOSPHORYLATED CREB BINDS SPECIFICALLY TO THE NUCLEAR-PROTEIN CBP PHOSPHORYLATED CREB BINDS SPECIFICALLY TO THE NUCLEAR-PROTEIN CBP NATURE, 365, 6449, 855-859 NATURE, 365, 6449, 855-859 NATURE, 365, 6449, 855-859 1993/10 英語 公開
JC CHRIVIA, RPS KWOK, N LAMB, M HAGIWARA, MR MONTMINY, RH GOODMAN JC CHRIVIA, RPS KWOK, N LAMB, M HAGIWARA, MR MONTMINY, RH GOODMAN JC CHRIVIA, RPS KWOK, N LAMB, M HAGIWARA, MR MONTMINY, RH GOODMAN PHOSPHORYLATED CREB BINDS SPECIFICALLY TO THE NUCLEAR-PROTEIN CBP PHOSPHORYLATED CREB BINDS SPECIFICALLY TO THE NUCLEAR-PROTEIN CBP PHOSPHORYLATED CREB BINDS SPECIFICALLY TO THE NUCLEAR-PROTEIN CBP NATURE, 365, 6449, 855-859 NATURE, 365, 6449, 855-859 NATURE, 365, 6449, 855-859 1993/10 英語 公開
Stimulus-transcripution coupling through the cAMP responsive factor CREB is rate-limited by the nuclear entry of PK-A Stimulus-transcripution coupling through the cAMP responsive factor CREB is rate-limited by the nuclear entry of PK-A Molecular and Cellular Biology, 13, 4852-4859 Molecular and Cellular Biology, 13, 4852-4859 , 13, 4852-4859 1993 公開
Stimulus-transcripution coupling through the cAMP responsive factor CREB is rate-limited by the nuclear entry of PK-A. Stimulus-transcripution coupling through the cAMP responsive factor CREB is rate-limited by the nuclear entry of PK-A. Stimulus-transcripution coupling through the cAMP responsive factor CREB is rate-limited by the nuclear entry of PK-A. Molecular and Cellular Biology, 13, 4852-4859 Molecular and Cellular Biology, 13, 4852-4859 Molecular and Cellular Biology, 13, 4852-4859 1993 公開
M HAGIWARA, A ALBERTS, P BRINDLE, J MEINKOTH, J FERAMISCO, T DENG, M KARIN, S SHENOLIKAR, M MONTMINY M HAGIWARA, A ALBERTS, P BRINDLE, J MEINKOTH, J FERAMISCO, T DENG, M KARIN, S SHENOLIKAR, M MONTMINY M HAGIWARA, A ALBERTS, P BRINDLE, J MEINKOTH, J FERAMISCO, T DENG, M KARIN, S SHENOLIKAR, M MONTMINY TRANSCRIPTIONAL ATTENUATION FOLLOWING CAMP INDUCTION REQUIRES PP-1-MEDIATED DEPHOSPHORYLATION OF CREB TRANSCRIPTIONAL ATTENUATION FOLLOWING CAMP INDUCTION REQUIRES PP-1-MEDIATED DEPHOSPHORYLATION OF CREB TRANSCRIPTIONAL ATTENUATION FOLLOWING CAMP INDUCTION REQUIRES PP-1-MEDIATED DEPHOSPHORYLATION OF CREB CELL, 70, 1, 105-113 CELL, 70, 1, 105-113 CELL, 70, 1, 105-113 1992/07 英語 公開
M HAGIWARA, A ALBERTS, P BRINDLE, J MEINKOTH, J FERAMISCO, T DENG, M KARIN, S SHENOLIKAR, M MONTMINY M HAGIWARA, A ALBERTS, P BRINDLE, J MEINKOTH, J FERAMISCO, T DENG, M KARIN, S SHENOLIKAR, M MONTMINY M HAGIWARA, A ALBERTS, P BRINDLE, J MEINKOTH, J FERAMISCO, T DENG, M KARIN, S SHENOLIKAR, M MONTMINY TRANSCRIPTIONAL ATTENUATION FOLLOWING CAMP INDUCTION REQUIRES PP-1-MEDIATED DEPHOSPHORYLATION OF CREB TRANSCRIPTIONAL ATTENUATION FOLLOWING CAMP INDUCTION REQUIRES PP-1-MEDIATED DEPHOSPHORYLATION OF CREB TRANSCRIPTIONAL ATTENUATION FOLLOWING CAMP INDUCTION REQUIRES PP-1-MEDIATED DEPHOSPHORYLATION OF CREB CELL, 70, 1, 105-113 CELL, 70, 1, 105-113 CELL, 70, 1, 105-113 1992/07 英語 公開
S WAKUSAWA, S NAKAMURA, K TAJIMA, K MIYAMOTO, M HAGIWARA, H HIDAKA S WAKUSAWA, S NAKAMURA, K TAJIMA, K MIYAMOTO, M HAGIWARA, H HIDAKA S WAKUSAWA, S NAKAMURA, K TAJIMA, K MIYAMOTO, M HAGIWARA, H HIDAKA OVERCOMING OF VINBLASTINE RESISTANCE BY ISOQUINOLINESULFONAMIDE COMPOUNDS IN ADRIAMYCIN-RESISTANT LEUKEMIA-CELLS OVERCOMING OF VINBLASTINE RESISTANCE BY ISOQUINOLINESULFONAMIDE COMPOUNDS IN ADRIAMYCIN-RESISTANT LEUKEMIA-CELLS OVERCOMING OF VINBLASTINE RESISTANCE BY ISOQUINOLINESULFONAMIDE COMPOUNDS IN ADRIAMYCIN-RESISTANT LEUKEMIA-CELLS MOLECULAR PHARMACOLOGY, 41, 6, 1034-1038 MOLECULAR PHARMACOLOGY, 41, 6, 1034-1038 MOLECULAR PHARMACOLOGY, 41, 6, 1034-1038 1992/06 英語 公開
Identification of a 80 kDa calmodulin-binding protein as a new Ca2+/calmodulin-dependent kinase by renaturation blotting assay(RBA). Identification of a 80 kDa calmodulin-binding protein as a new Ca2+/calmodulin-dependent kinase by renaturation blotting assay(RBA). Identification of a 80 kDa calmodulin-binding protein as a new Ca2+/calmodulin-dependent kinase by renaturation blotting assay(RBA). Biochem. J., 281, 339-42 Biochem. J., 281, 339-42 Biochem. J., 281, 339-42 1992 公開
Accelerated proliferation and interleukin-2 production of thymocytes by stimulation of soluble anti-CD3 monoclonal antibody in transgenic mice carrying a rabbit protein kinase C alpha. Accelerated proliferation and interleukin-2 production of thymocytes by stimulation of soluble anti-CD3 monoclonal antibody in transgenic mice carrying a rabbit protein kinase C alpha. Accelerated proliferation and interleukin-2 production of thymocytes by stimulation of soluble anti-CD3 monoclonal antibody in transgenic mice carrying a rabbit protein kinase C alpha. J. Biol. Chem., 267, 18644-8 J. Biol. Chem., 267, 18644-8 J. Biol. Chem., 267, 18644-8 1992 公開

  • <<
  • >>
  • 表示
タイトル言語:
外部資金:競争的資金 (科学研究費補助金)
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
平成22年度、日本学術振興会 基盤研究(A) 代表 スプライシング暗号の解読による神経発生過程の解明
平成22年度、 厚生労働科学研究費補助金 肝炎等克服緊急対策研究事業 分担 肝炎ウイルス感染複製増殖過程の解明と新規治療法開発に関する研究
平成21年度、厚労科研費補助金 難治性疾患克服研究事業  代表 「未熟児網膜症の原因と治療に関する調査研究」
平成21年度、日本学術振興会 基盤研究(A) 代表 スプライシング暗号の解読による神経発生過程の解明
平成20年度、文部科学省 特定領域研究 代表 「ヘルペスウイルスRNAの核外輸送制御機構の解明」
平成20年度、日本学術振興会 基盤(B) 代表 「イントロレンスRNAの核外輸送の分子メカニズム」
平成20年度、日本学術振興会 基盤(C)+D5006 分担 「中枢神経系におけるプロテオームの多様化創出と部位特異的発現制御メカニズムの解明
基盤研究(A) 代表 タウ蛋白不安定化剤による新しいタウオパチー治療戦略の構築 2012〜2014
基盤研究(A) 代表 タウ蛋白不安定化剤による新しいタウオパチー治療戦略の構築 2012/04/01〜2015/03/31
基盤研究(A) 代表 タウ蛋白不安定化剤による新しいタウオパチー治療戦略の構築 (平成26年度分) 2014/04/01〜2015/03/31
基盤研究(S) 代表 CRISPRによるRNA病モデルiPS細胞・動物の構築と病態解明・治療薬創製 (平成27年度分) 2015/04/01〜2016/03/31
基盤研究(A) 代表 トランスクリプトームの人為的操作による遺伝病の治療 (平成27年度分) 2015/04/01〜2016/03/31
基盤研究(S) 代表 CRISPRによるRNA病モデルiPS細胞・動物の構築と病態解明・治療薬創製 (平成28年度分) 2016/04/01〜2017/03/31
基盤研究(S) 代表 CRISPRによるRNA病モデルiPS細胞・動物の構築と病態解明・治療薬創製 (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(S) 代表 CRISPRによるRNA病モデルiPS細胞・動物の構築と病態解明・治療薬創製 (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(S) 代表 CRISPRによるRNA病モデルiPS細胞・動物の構築と病態解明・治療薬創製 (平成30年度分) 2018/04/01〜2019/03/31
基盤研究(S) 代表 CRISPRによるRNA病モデルiPS細胞・動物の構築と病態解明・治療薬創製 (2019年度分) 2019/04/01〜2020/03/31

  • <<
  • >>
  • 表示
外部資金:競争的資金 (科学研究費補助金以外)
制度名 代表者名 研究課題(日本語) 研究課題(英語) 期間
文部科学省 創薬等ライフサイエンス研究支援基盤事業 萩原 正敏 「大型創薬研究基盤を活用した創薬オープンイノベーションの推進」(細胞アッセイから治験までのワンストップ創薬支援) 2012〜2016
文部科学省 創薬等ライフサイエンス研究支援基盤事業 萩原 正敏 「大型創薬研究基盤を活用した創薬オープンイノベーションの推進」(細胞アッセイから治験までのワンストップ創薬支援) (平成26年度分) 2014/04/01〜2015/03/31
文部科学省 医療研究開発推進事業費補助金 萩原 正敏 「大型創薬研究基盤を活用した創薬オープンイノベーションの推進」(細胞アッセイから治験までのワンストップ創薬支援) (平成27年度分) 2015/04/01〜2016/03/31
厚生労働省 医薬品等審査迅速化事業費補助金 萩原 正敏 医薬品分野(アルツハイマー病、非臨床評価、薬剤疫学) (平成27年度分) 2015/04/01〜2016/03/31
医療研究開発推進事業費補助金 萩原 正敏 「大型創薬研究基盤を活用した創薬オープンイノベーションの推進」(細胞アッセイから治験までのワンストップ創薬支援) (平成28年度分) 2016/04/01〜2017/03/31
医薬品等審査迅速化事業費補助金 萩原 正敏  医薬品分野(アルツハイマー病、非臨床評価、薬剤疫学) (平成28年度分) 2016/04/01〜2017/03/31
医療研究開発推進事業費補助金 萩原 正敏 臨床研究につなぐワンストップ創薬支援 (平成29年度分) 2017/04/01〜2018/03/31
医療研究開発推進事業費補助金 萩原 正敏 臨床研究につなぐワンストップ創薬支援 (平成30年度分) 2018/04/01〜2019/03/31
医療研究開発推進事業費補助金 萩原 正敏 臨床研究につなぐワンストップ創薬支援 (2019年度分) 2019/04/01〜2020/03/31
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
医科学研究 前期不定 医学研究科 2011/04〜2012/03
A2 肉眼解剖学講義実習 Human Gross Anatomy and its Laboratory Course 前期 医学部 2013/04〜2014/03
医学概論 Introduction to medical science 通年 全学共通科目 2013/04〜2014/03
体験的医学研究入門 Hands-on medical research experience 前期集中 全学共通科目 2013/04〜2014/03
A2 肉眼解剖学講義実習 Human Gross Anatomy and its Laboratory Course 前期 医学部 2014/04〜2015/03
医学研究技術実習 Practicum on Medical Research 通年不定 医学研究科 2014/04〜2015/03
人体解剖学(LIMS) Human Anatomy 前期集中 医学研究科 2014/04〜2015/03
人体解剖学 Human Anatomy 前期 工学研究科 2014/04〜2015/03
人体構造学 Human Anatomy 前期 総合生存学館 2014/04〜2015/03
医学概論 Introduction to medical science 通年 全学共通科目 2014/04〜2015/03
体験的医学研究入門 Hands-on medical research experience 前期集中 全学共通科目 2014/04〜2015/03
A2 肉眼解剖学講義実習 Human Gross Anatomy and its Laboratory Course 前期 医学部 2015/04〜2016/03
人体構造学 Human Anatomy 前期 総合生存学館 2015/04〜2016/03
人体解剖学 Human Anatomy 前期 工学研究科 2015/04〜2016/03
人体解剖学(LIMS) Human Anatomy 前期集中 医学研究科 2015/04〜2016/03
医学概論 Introduction to medical science 通年 全学共通科目 2015/04〜2016/03
医学研究技術実習 Practicum on Medical Research 通年不定 医学研究科 2015/04〜2016/03
A2 肉眼解剖学講義実習 Human Gross Anatomy and its Laboratory Course 前期 医学部 2016/04〜2017/03
人体構造学 Human Anatomy 前期 総合生存学館 2016/04〜2017/03
人体解剖学 Human Anatomy 前期 工学研究科 2016/04〜2017/03
人体解剖学(LIMS) Human Anatomy 前期集中 医学研究科 2016/04〜2017/03
医学研究技術実習 Practicum on Medical Research 通年不定 医学研究科 2016/04〜2017/03
A2 肉眼解剖学講義実習 Human Gross Anatomy and its Laboratory Course 前期 医学部 2017/04〜2018/03
B1 肉眼解剖学 Human Gross Anatomy and its Laboratory Course 前期 医学部 2017/04〜2018/03
人体解剖学 Human Anatomy 前期 工学研究科 2017/04〜2018/03
人体解剖学(LIMS) Human Anatomy (LIMS) 前期集中 医学研究科 2017/04〜2018/03
医学研究技術実習 Practicum on Medical Research 通年不定 医学研究科 2017/04〜2018/03
A2 肉眼解剖学講義実習 Human Gross Anatomy and its Laboratory Course 前期 医学部 2018/04〜2019/03
B1 肉眼解剖学 Human Gross Anatomy and its Laboratory Course 前期 医学部 2018/04〜2019/03
人体解剖学 Human Anatomy 前期 工学研究科 2018/04〜2019/03
人体解剖学(LIMS) Human Anatomy (LIMS) 前期集中 医学研究科 2018/04〜2019/03
医学研究技術実習 Practicum on Medical Research 通年不定 医学研究科 2018/04〜2019/03
A2 肉眼解剖学講義実習 Human Gross Anatomy and its Laboratory Course 前期 医学部 2019/04〜2020/03
B1 肉眼解剖学 Human Gross Anatomy and its Laboratory Course 前期 医学部 2019/04〜2020/03
人体解剖学(LIMS) Human Anatomy (LIMS) 前期集中 医学研究科 2019/04〜2020/03
医学研究技術実習 Practicum on Medical Research 通年不定 医学研究科 2019/04〜2020/03
A2 肉眼解剖学講義実習 Human Gross Anatomy and its Laboratory Course 前期 医学部 2020/04〜2021/03
B1 肉眼解剖学 Human Gross Anatomy and its Laboratory Course 前期 医学部 2020/04〜2021/03
人体解剖学(LIMS) Human Anatomy (LIMS) 前期集中 医学研究科 2020/04〜2021/03
医学研究技術実習 Practicum on Medical Research 通年不定 医学研究科 2020/04〜2021/03

  • <<
  • >>
  • 表示
全学運営(役職等)
役職名 期間
設備整備ワーキンググループ委員会 2012/04/01〜2014/03/31
設備整備ワーキンググループ 委員 2012/04/01〜2014/09/30
先天異常標本解析センター長 2013/01/31〜2017/01/30
総合解剖センター長 2013/01/31〜2017/01/30
設備整備ワーキンググループ 座長 2014/10/01〜2016/09/30
財務委員会 委員 2014/10/01〜2016/09/30
総合技術部委員会 委員 2016/01/14〜2016/09/30
医・薬学域長 2016/04/01〜2018/03/31
基礎・社会医学系長 2016/04/01〜2018/03/31
評価に応じた予算配分に係る制度検討ワーキンググループ 委員 2016/04/01〜2016/09/30
指定国立大学法人制度検討ワーキンググループ委員 2016/07/12〜
指定国立大学法人制度検討タスクフォース 委員 2016/09/30〜2017/03/31
総合技術部委員会 委員 2016/01/14〜2018/09/30
運営協議員 2016/04/01〜2018/03/31
医・薬学域長 2016/04/01〜2020/03/31
基礎・社会医学系長 2016/04/01〜2020/03/31
理事補 2017/11/01〜2018/09/30
京都大学(南部)総合研究棟(医薬系)施設整備事業提案審査委員会の設置に伴う委員 2013/10/01〜
理事補 2017/11/01〜2020/09/30
企画委員会On-site Laboratory認定専門委員会 副委員長 2018/07/24〜2020/09/30
戦略調整会議 委員 2018/10/01〜2020/09/30
戦略調整会議On-site Laboratory小委員会 委員長 2018/10/01〜2020/09/30
戦略調整会議留学生リクルーティングオフィス小委員会 委員 2018/06/05〜2020/09/30
戦略調整会議授業料設定の柔軟化検討小委員会 委員長 2018/10/22〜2020/09/30
国際教育委員会国際学生交流委員会アムジェン・スカラーズ・プログラム小委員会 委員 2019/01/01〜2019/12/31
教育研究評議会 評議員 2018/10/01〜2021/03/31
高等研究院運営協議員委員 2018/04/01〜2020/03/31
産官学連携本部運営会議 2019/04/01〜2020/03/31
国際教育委員会国際学生交流委員会アムジェン・スカラーズ・プログラム小委員会 委員 2020/01/01〜2020/12/31

  • <<
  • >>
  • 表示
部局運営(役職等)
役職名 期間
解剖・先天異常標本解析センター委員会、委員
学位審査選定委員会、委員
利益相反予備審査委員会 2011/01/27〜
副研究科長 2013/10/01〜2018/09/30
医学広報委員会 2017/10/01〜2018/09/30
医学研究科・医学部人権委員会
医学研究科・医学部将来計画検討委員会 2013/10/01〜2021/03/31
医学研究科運営委員会 〜2014/03/31
医学部学務委員会 2012/05/10〜2016/03/31
医科学専攻長 2013/10/01〜2018/09/30
寄附講座運営委員会(免疫ゲノム医学) 2013/04/01〜2015/03/31
バイオ・フロンティア・プラットフォーム運営委員会 2012/01/26〜
附属ゲノム医学センター運営委員会 2013/04/01〜
医学研究支援センター運営委員会
寄附講座運営委員会(免疫ゲノム医学) 2016/04/01〜2020/03/31
寄附講座運営委員会(創薬医学) 2016/04/01〜2020/03/31
管理体制委員会 2017/10/01〜2020/09/30
脳機能総合研究センター運営委員会 2017/08/01〜2019/07/31
医学部資料館運営委員会
教員人事活性化委員会 2015/09/24〜
「医学領域」産学連携推進機構会議 2015/04/01〜
京都大学医薬系総合研究棟管理運営委員会 委員 2016/10/01〜2020/09/30
京都大学分子生物実験研究棟管理運営委員会 委員 2016/12/01〜2018/11/30
医学研究科・医学部財務委員会
評議員(附属病院) 2019/04/01〜2021/03/31
将来計画検討委員会 2019/04/01〜2021/03/31

  • <<
  • >>
  • 表示
その他活動:国・地方公共団体での活動
委員会名(日本語) 委員会名(英語) 役職名 公共団体の名称 期間
文部科学省 最先端研究基盤事業「化合物ライブラリーを活用した創薬等最先端研究・教育基盤の整備の選定」に関わる検討委員