藤田 芳久

最終更新日時: 2019/07/05 17:46:37

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氏名(漢字/フリガナ/アルファベット表記)
藤田 芳久/フジタ ヨシヒサ/Fujita, Yoshihisa
所属部署・職名(部局/所属/講座等/職名)
情報学研究科/システム科学専攻システム情報論講座/特定助教
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
博士(医学) 京都大学
researchmap URL
https://researchmap.jp/yoshihisa_fujita
研究テーマ
(日本語)
生命現象の計算モデリング
研究概要
(日本語)
複雑な生命現象の背後にあるメカニズムを数理的手法を用いて理解することを目指す。計算モデル構築、シミュレーションおよび大規模実験データの解析を駆使して研究を行う。
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
システム生物学 Systems biology
計算論的神経科学 Computational neuroscience
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Muta Y, Fujita Y, Sumiyama K, Sakurai A, Taketo MM, Chiba T, Seno H, Aoki K, Matsuda M, Imajo M Muta Y, Fujita Y, Sumiyama K, Sakurai A, Taketo MM, Chiba T, Seno H, Aoki K, Matsuda M, Imajo M Muta Y, Fujita Y, Sumiyama K, Sakurai A, Taketo MM, Chiba T, Seno H, Aoki K, Matsuda M, Imajo M Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine. Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine. Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine. Nature communications, 9, 1, 2174 Nature communications, 9, 1, 2174 Nature communications, 9, 1, 2174 2018/06 公開
Hiratsuka T, Fujita Y, Naoki H, Aoki K, Kamioka Y, Matsuda M Hiratsuka T, Fujita Y, Naoki H, Aoki K, Kamioka Y, Matsuda M Hiratsuka T, Fujita Y, Naoki H, Aoki K, Kamioka Y, Matsuda M Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin. Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin. Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin. eLife, 4, e05178 eLife, 4, e05178 eLife, 4, e05178 2015/02 公開
Komatsu N, Fujita Y, Matsuda M, Aoki K Komatsu N, Fujita Y, Matsuda M, Aoki K Komatsu N, Fujita Y, Matsuda M, Aoki K mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells. mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells. mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells. Oncogene Oncogene Oncogene 2015/02 公開
Fujita Y, Komatsu N, Matsuda M, Aoki K Fujita Y, Komatsu N, Matsuda M, Aoki K Fujita Y, Komatsu N, Matsuda M, Aoki K Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs. Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs. Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs. The FEBS journal, 281, 14, 3177-3192 The FEBS journal, 281, 14, 3177-3192 The FEBS journal, 281, 14, 3177-3192 2014/07 公開
Aoki K, Kumagai Y, Sakurai A, Komatsu N, Fujita Y, Shionyu C, Matsuda M Aoki K, Kumagai Y, Sakurai A, Komatsu N, Fujita Y, Shionyu C, Matsuda M Aoki K, Kumagai Y, Sakurai A, Komatsu N, Fujita Y, Shionyu C, Matsuda M Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation. Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation. Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation. Molecular cell, 52, 4, 529-540 Molecular cell, 52, 4, 529-540 Molecular cell, 52, 4, 529-540 2013/11 公開
Komatsu N, Aoki K, Yamada M, Yukinaga H, Fujita Y, Kamioka Y, Matsuda M Komatsu N, Aoki K, Yamada M, Yukinaga H, Fujita Y, Kamioka Y, Matsuda M Komatsu N, Aoki K, Yamada M, Yukinaga H, Fujita Y, Kamioka Y, Matsuda M Development of an optimized backbone of FRET biosensors for kinases and GTPases. Development of an optimized backbone of FRET biosensors for kinases and GTPases. Development of an optimized backbone of FRET biosensors for kinases and GTPases. Molecular biology of the cell, 22, 23, 4647-4656 Molecular biology of the cell, 22, 23, 4647-4656 Molecular biology of the cell, 22, 23, 4647-4656 2011/12 公開
Kamioka Y, Yasuda S, Fujita Y, Aoki K, Matsuda M Kamioka Y, Yasuda S, Fujita Y, Aoki K, Matsuda M Kamioka Y, Yasuda S, Fujita Y, Aoki K, Matsuda M Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK. Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK. Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK. The Journal of biological chemistry, 285, 43, 33540-33548 The Journal of biological chemistry, 285, 43, 33540-33548 The Journal of biological chemistry, 285, 43, 33540-33548 2010/10 公開
Matsunaga-Udagawa R, Fujita Y, Yoshiki S, Terai K, Kamioka Y, Kiyokawa E, Yugi K, Aoki K, Matsuda M Matsunaga-Udagawa R, Fujita Y, Yoshiki S, Terai K, Kamioka Y, Kiyokawa E, Yugi K, Aoki K, Matsuda M Matsunaga-Udagawa R, Fujita Y, Yoshiki S, Terai K, Kamioka Y, Kiyokawa E, Yugi K, Aoki K, Matsuda M The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf. The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf. The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf. The Journal of biological chemistry, 285, 10, 7818-7826 The Journal of biological chemistry, 285, 10, 7818-7826 The Journal of biological chemistry, 285, 10, 7818-7826 2010/03 公開
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