丹羽明

最終更新日時: 2018/11/01 17:56:15

氏名(漢字／フリガナ／アルファベット表記)

丹羽明／ニワアキラ／Niwa, Akira

所属部署・職名(部局／所属／講座等／職名)

ｉＰＳ細胞研究所／臨床応用研究部門／特定拠点助教

所属学会(国内)

学会名(日本語)	学会名(英語)
日本小児科学会
日本血液学会
日本再生医療学会

所属学会(海外)

学会名(英語)	国名
International Society for Stem Cell Research

取得学位

学位名(日本語)	学位名(英語)	大学(日本語)	大学(英語)	取得区分
博士（医学）		京都大学

研究テーマ

(英語)
1. Orderly differentiation system from human pluripotent stem cells (PSCs) towards mesodermal cells and various lineages of blood cells, and induction of PSC-derived hematopoietic stem cells 2. Identification of Functional characters and importance of an extracellular matrix Laminin 411 during vascular endothelial differentiation, and increase in efficacy and purity of iPSC-derived endothelial differentiation. 3. Elucidation of the pathology and discovery of novel therapeutic methods of intractable hematological/immunological diseases through PSC-based disease modeling. 4. Exploration of the pathology and discovery of novel therapy of hematological malignancy by combining in vivo and in vitro disease models

(英語)

1. Orderly differentiation system from human pluripotent stem cells (PSCs) towards mesodermal cells and various lineages of blood cells, and induction of PSC-derived hematopoietic stem cells 2. Identification of Functional characters and importance of an extracellular matrix Laminin 411 during vascular endothelial differentiation, and increase in efficacy and purity of iPSC-derived endothelial differentiation. 3. Elucidation of the pathology and discovery of novel therapeutic methods of intractable hematological/immunological diseases through PSC-based disease modeling. 4. Exploration of the pathology and discovery of novel therapy of hematological malignancy by combining in vivo and in vitro disease models

研究概要

(英語)
1. Orderly differentiation system from human pluripotent stem cells (PSCs) towards mesodermal cells and various lineages of blood cells, and induction of PSC-derived hematopoietic stem cells Discovered PET-based collagen sponges allow longer culture times of PSC-derived hematopoietic stem/progenitor cells, leading to increase in the number of them. Established a novel serum-free monolayer culture that can trace the in vivo hematopoietic pathway from ES/iPS cells to functional definitive blood cells via mesodermal progenitors. Further improved, it has been used in all projects in our laboratory to elucidate the pathologies of various diseases through PSC-based disease model. 2. Identification of Functional characters and importance of an extracellular matrix Laminin 411 during vascular endothelial differentiation, and increase in efficacy and purity of iPSC-derived endothelial differentiation. Discovered LM411, a minor extracellular matrix located around blood vessels, is effective at specifying the lineage towards endothelial cells from mesoderm. Furthermore, single-cell RNA-seq study revealed that Rho signals bridge between downstream of LM411 and a common endothelial growth hormone VEGF at the specific stage of differentiation to endothelial cells. 3. Elucidation of the pathology and discovery of novel therapeutic methods of intractable hematological/immunological diseases through PSC-based disease modeling. As a part of AMED Research Center Network for Realization of Regenerative Medicine, drove the studies to explore the pathophysiology of intractable hematological/immunological diseases including Blau syndrome, CINCA syndrome, Fanconi anemia and Severe congenital neutropenia. Contribution: designing experiments, analyzing and preparing data and writing texts. 4. Exploration of the pathology and discovery of novel therapy of hematological malignancy by combining in vivo and in vitro disease models In collaboration with division of Pediatrics, Kyoto University, established the in vivo model of leukemia with poor prognosis to elucidate the pathophysiology especially in extramedullary sites such as liver and central nervous system, leading to discover the niche-like histology and identify the mechanisms in adaptation of leukemic cells in those organs.

(英語)

1. Orderly differentiation system from human pluripotent stem cells (PSCs) towards mesodermal cells and various lineages of blood cells, and induction of PSC-derived hematopoietic stem cells Discovered PET-based collagen sponges allow longer culture times of PSC-derived hematopoietic stem/progenitor cells, leading to increase in the number of them. Established a novel serum-free monolayer culture that can trace the in vivo hematopoietic pathway from ES/iPS cells to functional definitive blood cells via mesodermal progenitors. Further improved, it has been used in all projects in our laboratory to elucidate the pathologies of various diseases through PSC-based disease model. 2. Identification of Functional characters and importance of an extracellular matrix Laminin 411 during vascular endothelial differentiation, and increase in efficacy and purity of iPSC-derived endothelial differentiation. Discovered LM411, a minor extracellular matrix located around blood vessels, is effective at specifying the lineage towards endothelial cells from mesoderm. Furthermore, single-cell RNA-seq study revealed that Rho signals bridge between downstream of LM411 and a common endothelial growth hormone VEGF at the specific stage of differentiation to endothelial cells. 3. Elucidation of the pathology and discovery of novel therapeutic methods of intractable hematological/immunological diseases through PSC-based disease modeling. As a part of AMED Research Center Network for Realization of Regenerative Medicine, drove the studies to explore the pathophysiology of intractable hematological/immunological diseases including Blau syndrome, CINCA syndrome, Fanconi anemia and Severe congenital neutropenia. Contribution: designing experiments, analyzing and preparing data and writing texts. 4. Exploration of the pathology and discovery of novel therapy of hematological malignancy by combining in vivo and in vitro disease models In collaboration with division of Pediatrics, Kyoto University, established the in vivo model of leukemia with poor prognosis to elucidate the pathophysiology especially in extramedullary sites such as liver and central nervous system, leading to discover the niche-like histology and identify the mechanisms in adaptation of leukemic cells in those organs.

研究分野（キーワード）

キーワード(日本語)	キーワード(英語)
小児科学	Pediatrics
血液学	Hematology
幹細胞生物学	Stem cell biology
疾患再現医学	Disease modeling
再生医学	Regenerative medicine

研究分野（科研費分類コード）

科研費分類コード
小児科学
血液内科学
細胞生物学

論文

著者	著者(日本語)	著者(英語)	タイトル	タイトル(日本語)	タイトル(英語)	書誌情報等	書誌情報等(日本語)	書誌情報等(英語)	出版年月	査読の有無	記述言語	公開
Taoka K, Arai S, Kataoka K, Hosoi M, Miyauchi M, Yamazaki S, Honda A, Aixinjueluo W, Kobayashi T, Kumano K, Yoshimi A, Otsu M, Niwa A, Nakahata T, Nakauchi H, Kurokawa M	Taoka K, Arai S, Kataoka K, Hosoi M, Miyauchi M, Yamazaki S, Honda A, Aixinjueluo W, Kobayashi T, Kumano K, Yoshimi A, Otsu M, Niwa A, Nakahata T, Nakauchi H, Kurokawa M	Taoka K, Arai S, Kataoka K, Hosoi M, Miyauchi M, Yamazaki S, Honda A, Aixinjueluo W, Kobayashi T, Kumano K, Yoshimi A, Otsu M, Niwa A, Nakahata T, Nakauchi H, Kurokawa M	Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate.	Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate.	Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate.	Scientific reports, 8, 1, 15855	Scientific reports, 8, 1, 15855	Scientific reports, 8, 1, 15855	2018/10	有		公開
Ono H, Ohta R, Kawasaki Y, Niwa A, Takada H, Nakahata T, Ohga S, Saito MK	Ono H, Ohta R, Kawasaki Y, Niwa A, Takada H, Nakahata T, Ohga S, Saito MK	Ono H, Ohta R, Kawasaki Y, Niwa A, Takada H, Nakahata T, Ohga S, Saito MK	Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells.	Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells.	Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells.	Inflammation research : official journal of the European Histamine Research Society ... [et al.], 67, 10, 879-889	Inflammation research : official journal of the European Histamine Research Society ... [et al.], 67, 10, 879-889	Inflammation research : official journal of the European Histamine Research Society ... [et al.], 67, 10, 879-889	2018/10	有		公開
Honda-Ozaki F, Terashima M, Niwa A, Saiki N, Kawasaki Y, Ito H, Hotta A, Nagahashi A, Igura K, Asaka I, Li HL, Yanagimachi M, Furukawa F, Kanazawa N, Nakahata T, Saito MK	Honda-Ozaki F, Terashima M, Niwa A, Saiki N, Kawasaki Y, Ito H, Hotta A, Nagahashi A, Igura K, Asaka I, Li HL, Yanagimachi M, Furukawa F, Kanazawa N, Nakahata T, Saito MK	Honda-Ozaki F, Terashima M, Niwa A, Saiki N, Kawasaki Y, Ito H, Hotta A, Nagahashi A, Igura K, Asaka I, Li HL, Yanagimachi M, Furukawa F, Kanazawa N, Nakahata T, Saito MK	Pluripotent Stem Cell Model of Nakajo-Nishimura Syndrome Untangles Proinflammatory Pathways Mediated by Oxidative Stress.	Pluripotent Stem Cell Model of Nakajo-Nishimura Syndrome Untangles Proinflammatory Pathways Mediated by Oxidative Stress.	Pluripotent Stem Cell Model of Nakajo-Nishimura Syndrome Untangles Proinflammatory Pathways Mediated by Oxidative Stress.	Stem cell reports	Stem cell reports	Stem cell reports	2018/05	有		公開
Oshima K, Saiki N, Tanaka M, Imamura H, Niwa A, Tanimura A, Nagahashi A, Hirayama A, Okita K, Hotta A, Kitayama S, Osawa M, Kaneko S, Watanabe A, Asaka I, Fujibuchi W, Imai K, Yabe H, Kamachi Y, Hara J, Kojima S, Tomita M, Soga T, Noma T, Nonoyama S, Nakahata T, Saito MK	Oshima K, Saiki N, Tanaka M, Imamura H, Niwa A, Tanimura A, Nagahashi A, Hirayama A, Okita K, Hotta A, Kitayama S, Osawa M, Kaneko S, Watanabe A, Asaka I, Fujibuchi W, Imai K, Yabe H, Kamachi Y, Hara J, Kojima S, Tomita M, Soga T, Noma T, Nonoyama S, Nakahata T, Saito MK	Oshima K, Saiki N, Tanaka M, Imamura H, Niwa A, Tanimura A, Nagahashi A, Hirayama A, Okita K, Hotta A, Kitayama S, Osawa M, Kaneko S, Watanabe A, Asaka I, Fujibuchi W, Imai K, Yabe H, Kamachi Y, Hara J, Kojima S, Tomita M, Soga T, Noma T, Nonoyama S, Nakahata T, Saito MK	Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors.	Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors.	Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors.	Biochemical and biophysical research communications, 497, 2, 719-725	Biochemical and biophysical research communications, 497, 2, 719-725	Biochemical and biophysical research communications, 497, 2, 719-725	2018/03	有		公開
Takada S, Kambe N, Kawasaki Y, Niwa A, Honda-Ozaki F, Kobayashi K, Osawa M, Nagahashi A, Semi K, Hotta A, Asaka I, Yamada Y, Nishikomori R, Heike T, Matsue H, Nakahata T, Saito MK	Takada S, Kambe N, Kawasaki Y, Niwa A, Honda-Ozaki F, Kobayashi K, Osawa M, Nagahashi A, Semi K, Hotta A, Asaka I, Yamada Y, Nishikomori R, Heike T, Matsue H, Nakahata T, Saito MK	Takada S, Kambe N, Kawasaki Y, Niwa A, Honda-Ozaki F, Kobayashi K, Osawa M, Nagahashi A, Semi K, Hotta A, Asaka I, Yamada Y, Nishikomori R, Heike T, Matsue H, Nakahata T, Saito MK	Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages.	Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages.	Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages.	The Journal of allergy and clinical immunology, 141, 1, 339-349.e11	The Journal of allergy and clinical immunology, 141, 1, 339-349.e11	The Journal of allergy and clinical immunology, 141, 1, 339-349.e11	2018/01	有		公開
Hitomi H, Kasahara T, Katagiri N, Hoshina A, Mae SI, Kotaka M, Toyohara T, Rahman A, Nakano D, Niwa A, Saito MK, Nakahata T, Nishiyama A, Osafune K	Hitomi H, Kasahara T, Katagiri N, Hoshina A, Mae SI, Kotaka M, Toyohara T, Rahman A, Nakano D, Niwa A, Saito MK, Nakahata T, Nishiyama A, Osafune K	Hitomi H, Kasahara T, Katagiri N, Hoshina A, Mae SI, Kotaka M, Toyohara T, Rahman A, Nakano D, Niwa A, Saito MK, Nakahata T, Nishiyama A, Osafune K	Human pluripotent stem cell-derived erythropoietin-producing cells ameliorate renal anemia in mice.	Human pluripotent stem cell-derived erythropoietin-producing cells ameliorate renal anemia in mice.	Human pluripotent stem cell-derived erythropoietin-producing cells ameliorate renal anemia in mice.	Science translational medicine, 9, 409	Science translational medicine, 9, 409	Science translational medicine, 9, 409	2017/09	有		公開
Kato I, Nishinaka Y, Nakamura M, Akarca AU, Niwa A, Ozawa H, Yoshida K, Mori M, Wang D, Morita M, Ueno H, Shiozawa Y, Shiraishi Y, Miyano S, Gupta R, Umeda K, Watanabe K, Koh K, Adachi S, Heike T, Saito MK, Sanada M, Ogawa S, Marafioti T, Watanabe A, Nakahata T, Enver T	Kato I, Nishinaka Y, Nakamura M, Akarca AU, Niwa A, Ozawa H, Yoshida K, Mori M, Wang D, Morita M, Ueno H, Shiozawa Y, Shiraishi Y, Miyano S, Gupta R, Umeda K, Watanabe K, Koh K, Adachi S, Heike T, Saito MK, Sanada M, Ogawa S, Marafioti T, Watanabe A, Nakahata T, Enver T	Kato I, Nishinaka Y, Nakamura M, Akarca AU, Niwa A, Ozawa H, Yoshida K, Mori M, Wang D, Morita M, Ueno H, Shiozawa Y, Shiraishi Y, Miyano S, Gupta R, Umeda K, Watanabe K, Koh K, Adachi S, Heike T, Saito MK, Sanada M, Ogawa S, Marafioti T, Watanabe A, Nakahata T, Enver T	Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA.	Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA.	Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA.	Blood, 129, 23, 3126-3129	Blood, 129, 23, 3126-3129	Blood, 129, 23, 3126-3129	2017/06	有		公開
Kawasaki Y, Oda H, Ito J, Niwa A, Tanaka T, Hijikata A, Seki R, Nagahashi A, Osawa M, Asaka I, Watanabe A, Nishimata S, Shirai T, Kawashima H, Ohara O, Nakahata T, Nishikomori R, Heike T, Saito MK	Kawasaki Y, Oda H, Ito J, Niwa A, Tanaka T, Hijikata A, Seki R, Nagahashi A, Osawa M, Asaka I, Watanabe A, Nishimata S, Shirai T, Kawashima H, Ohara O, Nakahata T, Nishikomori R, Heike T, Saito MK	Kawasaki Y, Oda H, Ito J, Niwa A, Tanaka T, Hijikata A, Seki R, Nagahashi A, Osawa M, Asaka I, Watanabe A, Nishimata S, Shirai T, Kawashima H, Ohara O, Nakahata T, Nishikomori R, Heike T, Saito MK	Identification of a High-Frequency Somatic NLRC4 Mutation as a Cause of Autoinflammation by Pluripotent Cell-Based Phenotype Dissection.	Identification of a High-Frequency Somatic NLRC4 Mutation as a Cause of Autoinflammation by Pluripotent Cell-Based Phenotype Dissection.	Identification of a High-Frequency Somatic NLRC4 Mutation as a Cause of Autoinflammation by Pluripotent Cell-Based Phenotype Dissection.	Arthritis & rheumatology (Hoboken, N.J.), 69, 2, 447-459	Arthritis & rheumatology (Hoboken, N.J.), 69, 2, 447-459	Arthritis & rheumatology (Hoboken, N.J.), 69, 2, 447-459	2017/02	有		公開
Sugimine Y, Niwa A, Matsubara H, Kobayashi K, Tabata Y, Heike T, Nakahata T, Saito MK	Sugimine Y, Niwa A, Matsubara H, Kobayashi K, Tabata Y, Heike T, Nakahata T, Saito MK	Sugimine Y, Niwa A, Matsubara H, Kobayashi K, Tabata Y, Heike T, Nakahata T, Saito MK	A portable platform for stepwise hematopoiesis from human pluripotent stem cells within PET-reinforced collagen sponges.	A portable platform for stepwise hematopoiesis from human pluripotent stem cells within PET-reinforced collagen sponges.	A portable platform for stepwise hematopoiesis from human pluripotent stem cells within PET-reinforced collagen sponges.	International journal of hematology, 104, 6, 647-660	International journal of hematology, 104, 6, 647-660	International journal of hematology, 104, 6, 647-660	2016/12	有		公開
Ohta R, Niwa A, Taniguchi Y, Suzuki NM, Toga J, Yagi E, Saiki N, Nishinaka-Arai Y, Okada C, Watanabe A, Nakahata T, Sekiguchi K, Saito MK	Ohta R, Niwa A, Taniguchi Y, Suzuki NM, Toga J, Yagi E, Saiki N, Nishinaka-Arai Y, Okada C, Watanabe A, Nakahata T, Sekiguchi K, Saito MK	Ohta R, Niwa A, Taniguchi Y, Suzuki NM, Toga J, Yagi E, Saiki N, Nishinaka-Arai Y, Okada C, Watanabe A, Nakahata T, Sekiguchi K, Saito MK	Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells.	Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells.	Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells.	Scientific reports, 6, 35680	Scientific reports, 6, 35680	Scientific reports, 6, 35680	2016/11	有		公開
Nemoto A, Saida S, Kato I, Kikuchi J, Furukawa Y, Maeda Y, Akahane K, Honna-Oshiro H, Goi K, Kagami K, Kimura S, Sato Y, Okabe S, Niwa A, Watanabe K, Nakahata T, Heike T, Sugita K, Inukai T	Nemoto A, Saida S, Kato I, Kikuchi J, Furukawa Y, Maeda Y, Akahane K, Honna-Oshiro H, Goi K, Kagami K, Kimura S, Sato Y, Okabe S, Niwa A, Watanabe K, Nakahata T, Heike T, Sugita K, Inukai T	Nemoto A, Saida S, Kato I, Kikuchi J, Furukawa Y, Maeda Y, Akahane K, Honna-Oshiro H, Goi K, Kagami K, Kimura S, Sato Y, Okabe S, Niwa A, Watanabe K, Nakahata T, Heike T, Sugita K, Inukai T	Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome-Positive Lymphoid Leukemia.	Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome-Positive Lymphoid Leukemia.	Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome-Positive Lymphoid Leukemia.	Molecular cancer therapeutics, 15, 1, 94-105	Molecular cancer therapeutics, 15, 1, 94-105	Molecular cancer therapeutics, 15, 1, 94-105	2016/01	有		公開
Saida S, Watanabe K, Kato I, Fujino H, Umeda K, Okamoto S, Uemoto S, Hishiki T, Yoshida H, Tanaka S, Adachi S, Niwa A, Nakahata T, Heike T	Saida S, Watanabe K, Kato I, Fujino H, Umeda K, Okamoto S, Uemoto S, Hishiki T, Yoshida H, Tanaka S, Adachi S, Niwa A, Nakahata T, Heike T	Saida S, Watanabe K, Kato I, Fujino H, Umeda K, Okamoto S, Uemoto S, Hishiki T, Yoshida H, Tanaka S, Adachi S, Niwa A, Nakahata T, Heike T	Prognostic significance of aminopeptidase-N (CD13) in hepatoblastoma.	Prognostic significance of aminopeptidase-N (CD13) in hepatoblastoma.	Prognostic significance of aminopeptidase-N (CD13) in hepatoblastoma.	Pediatrics international : official journal of the Japan Pediatric Society, 57, 4, 558-566	Pediatrics international : official journal of the Japan Pediatric Society, 57, 4, 558-566	Pediatrics international : official journal of the Japan Pediatric Society, 57, 4, 558-566	2015/08	有		公開
Suzuki NM, Niwa A, Yabe M, Hira A, Okada C, Amano N, Watanabe A, Watanabe K, Heike T, Takata M, Nakahata T, Saito MK	Suzuki NM, Niwa A, Yabe M, Hira A, Okada C, Amano N, Watanabe A, Watanabe K, Heike T, Takata M, Nakahata T, Saito MK	Suzuki NM, Niwa A, Yabe M, Hira A, Okada C, Amano N, Watanabe A, Watanabe K, Heike T, Takata M, Nakahata T, Saito MK	Pluripotent cell models of fanconi anemia identify the early pathological defect in human hemoangiogenic progenitors.	Pluripotent cell models of fanconi anemia identify the early pathological defect in human hemoangiogenic progenitors.	Pluripotent cell models of fanconi anemia identify the early pathological defect in human hemoangiogenic progenitors.	Stem cells translational medicine, 4, 4, 333-338	Stem cells translational medicine, 4, 4, 333-338	Stem cells translational medicine, 4, 4, 333-338	2015/04	有		公開
T. Morishima; K. Watanabe; A. Niwa; H. Hirai; S. Saida; T. Tanaka; I. Kato; K. Umeda; H. Hiramatsu; M.K. Saito; K. Matsubara; S. Adachi; M. Kobayashi; T. Nakahata; T. Heike	T. Morishima; K. Watanabe; A. Niwa; H. Hirai; S. Saida; T. Tanaka; I. Kato; K. Umeda; H. Hiramatsu; M.K. Saito; K. Matsubara; S. Adachi; M. Kobayashi; T. Nakahata; T. Heike	T. Morishima; K. Watanabe; A. Niwa; H. Hirai; S. Saida; T. Tanaka; I. Kato; K. Umeda; H. Hiramatsu; M.K. Saito; K. Matsubara; S. Adachi; M. Kobayashi; T. Nakahata; T. Heike	Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis	Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis	Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis	Haematologica, 99, 1, 19-27	Haematologica, 99, 1, 19-27	Haematologica, 99, 1, 19-27	2014/01	有	英語	公開
T. Sato; T. Kitawaki; H. Fujita; M. Iwata; T. Iyoda; K. Inaba; T. Ohteki; S. Hasegawa; K. Kawada; Y. Sakai; H. Ikeuchi; H. Nakase; A. Niwa; A. Takaori-Kondo; N. Kadowaki	T. Sato; T. Kitawaki; H. Fujita; M. Iwata; T. Iyoda; K. Inaba; T. Ohteki; S. Hasegawa; K. Kawada; Y. Sakai; H. Ikeuchi; H. Nakase; A. Niwa; A. Takaori-Kondo; N. Kadowaki	T. Sato; T. Kitawaki; H. Fujita; M. Iwata; T. Iyoda; K. Inaba; T. Ohteki; S. Hasegawa; K. Kawada; Y. Sakai; H. Ikeuchi; H. Nakase; A. Niwa; A. Takaori-Kondo; N. Kadowaki	Human CD1c<sup>+</sup> myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D<sub>3</sub>	Human CD1c<sup>+</sup> myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D<sub>3</sub>	Human CD1c<sup>+</sup> myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D<sub>3</sub>	Journal of Immunology, 191, 6, 3152-3160	Journal of Immunology, 191, 6, 3152-3160	Journal of Immunology, 191, 6, 3152-3160	2013/09	有	英語	公開
M.D. Yanagimachi; A. Niwa; T. Tanaka; F. Honda-Ozaki; S. Nishimoto; Y. Murata; T. Yasumi; J. Ito; S. Tomida; K. Oshima; I. Asaka; H. Goto; T. Heike; T. Nakahata; M.K. Saito	M.D. Yanagimachi; A. Niwa; T. Tanaka; F. Honda-Ozaki; S. Nishimoto; Y. Murata; T. Yasumi; J. Ito; S. Tomida; K. Oshima; I. Asaka; H. Goto; T. Heike; T. Nakahata; M.K. Saito	M.D. Yanagimachi; A. Niwa; T. Tanaka; F. Honda-Ozaki; S. Nishimoto; Y. Murata; T. Yasumi; J. Ito; S. Tomida; K. Oshima; I. Asaka; H. Goto; T. Heike; T. Nakahata; M.K. Saito	Robust and Highly-Efficient Differentiation of Functional Monocytic Cells from Human Pluripotent Stem Cells under Serum- and Feeder Cell-Free Conditions	Robust and Highly-Efficient Differentiation of Functional Monocytic Cells from Human Pluripotent Stem Cells under Serum- and Feeder Cell-Free Conditions	Robust and Highly-Efficient Differentiation of Functional Monocytic Cells from Human Pluripotent Stem Cells under Serum- and Feeder Cell-Free Conditions	PLoS ONE, 8, 4, e59243	PLoS ONE, 8, 4, e59243	PLoS ONE, 8, 4, e59243	2013/04/03	有	英語	公開
T. Tanaka; K. Takahashi; M. Yamane; S. Tomida; S. Nakamura; K. Oshima; A. Niwa; R. Nishikomori; N. Kambe; H. Hara; M. Mitsuyama; N. Morone; J.E. Heuser; T. Yamamoto; A. Watanabe; A. Sato-Otsubo; S. Ogawa; I. Asaka; T. Heike; S. Yamanaka; T. Nakahata; M.K. Saito	T. Tanaka; K. Takahashi; M. Yamane; S. Tomida; S. Nakamura; K. Oshima; A. Niwa; R. Nishikomori; N. Kambe; H. Hara; M. Mitsuyama; N. Morone; J.E. Heuser; T. Yamamoto; A. Watanabe; A. Sato-Otsubo; S. Ogawa; I. Asaka; T. Heike; S. Yamanaka; T. Nakahata; M.K. Saito	T. Tanaka; K. Takahashi; M. Yamane; S. Tomida; S. Nakamura; K. Oshima; A. Niwa; R. Nishikomori; N. Kambe; H. Hara; M. Mitsuyama; N. Morone; J.E. Heuser; T. Yamamoto; A. Watanabe; A. Sato-Otsubo; S. Ogawa; I. Asaka; T. Heike; S. Yamanaka; T. Nakahata; M.K. Saito	Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery	Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery	Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery	Blood, 120, 6, 1299-1308	Blood, 120, 6, 1299-1308	Blood, 120, 6, 1299-1308	2012/08/09	有	英語	公開
T. Awaya; T. Kato; Y. Mizuno; H. Chang; A. Niwa; K. Umeda; T. Nakahata; T. Heike	T. Awaya; T. Kato; Y. Mizuno; H. Chang; A. Niwa; K. Umeda; T. Nakahata; T. Heike	T. Awaya; T. Kato; Y. Mizuno; H. Chang; A. Niwa; K. Umeda; T. Nakahata; T. Heike	Selective Development of Myogenic Mesenchymal Cells from Human Embryonic and Induced Pluripotent Stem Cells	Selective Development of Myogenic Mesenchymal Cells from Human Embryonic and Induced Pluripotent Stem Cells	Selective Development of Myogenic Mesenchymal Cells from Human Embryonic and Induced Pluripotent Stem Cells	PLoS ONE, 7, 12, e51638	PLoS ONE, 7, 12, e51638	PLoS ONE, 7, 12, e51638	2012	有	英語	公開
S. Wakao; M. Kitada; Y. Kuroda; F. Ogura; T. Murakami; A. Niwa; M. Dezawa	S. Wakao; M. Kitada; Y. Kuroda; F. Ogura; T. Murakami; A. Niwa; M. Dezawa	S. Wakao; M. Kitada; Y. Kuroda; F. Ogura; T. Murakami; A. Niwa; M. Dezawa	Morphologic and Gene Expression Criteria for Identifying Human Induced Pluripotent Stem Cells	Morphologic and Gene Expression Criteria for Identifying Human Induced Pluripotent Stem Cells	Morphologic and Gene Expression Criteria for Identifying Human Induced Pluripotent Stem Cells	PLoS ONE, 7, 12, e48677	PLoS ONE, 7, 12, e48677	PLoS ONE, 7, 12, e48677	2012	有	英語	公開
SAITO Megumu K.;NIWA Akira	SAITO Megumu K.;NIWA Akira	SAITO Megumu K.;NIWA Akira	Disease-associated iPS cell lines representing hematological and immunological disorders	Disease-associated iPS cell lines representing hematological and immunological disorders	Disease-associated iPS cell lines representing hematological and immunological disorders	Inflamm Regen (Web), 32, 4, 171-177 (J-STAGE)	Inflamm Regen (Web), 32, 4, 171-177 (J-STAGE)	Inflamm Regen (Web), 32, 4, 171-177 (J-STAGE)	2012	有	英語	公開
T. Awaya; T. Kato; A. Niwa; H. Hiramatsu; K. Umeda; K.-I. Watanabe; M. Shibata; Y. Yamanaka; E. Maruya; H. Saji; T. Nakahata; S. Adachi	T. Awaya; T. Kato; A. Niwa; H. Hiramatsu; K. Umeda; K.-I. Watanabe; M. Shibata; Y. Yamanaka; E. Maruya; H. Saji; T. Nakahata; S. Adachi	T. Awaya; T. Kato; A. Niwa; H. Hiramatsu; K. Umeda; K.-I. Watanabe; M. Shibata; Y. Yamanaka; E. Maruya; H. Saji; T. Nakahata; S. Adachi	Successful cord blood transplantation using a reduced-intensity conditioning regimen for advanced childhood-onset cerebral adrenoleukodystrophy	Successful cord blood transplantation using a reduced-intensity conditioning regimen for advanced childhood-onset cerebral adrenoleukodystrophy	Successful cord blood transplantation using a reduced-intensity conditioning regimen for advanced childhood-onset cerebral adrenoleukodystrophy	Pediatric Transplantation, 15, 6, 116-120	Pediatric Transplantation, 15, 6, 116-120	Pediatric Transplantation, 15, 6, 116-120	2011/09	有	英語	公開
Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Akatsuka M, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S	Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Akatsuka M, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S	Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Akatsuka M, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S	[Frequent inactivation of A20 through gene mutation in B-cell lymphomas].	[Frequent inactivation of A20 through gene mutation in B-cell lymphomas].	[Frequent inactivation of A20 through gene mutation in B-cell lymphomas].	[Rinsho ketsueki] The Japanese journal of clinical hematology, 52, 6, 313-319	[Rinsho ketsueki] The Japanese journal of clinical hematology, 52, 6, 313-319	[Rinsho ketsueki] The Japanese journal of clinical hematology, 52, 6, 313-319	2011/06	有		公開
T. Morishima; K.-I. Watanabe; A. Niwa; H. Fujino; H. Matsubara; S. Adachi; H. Suemori; T. Nakahata; T. Heike	T. Morishima; K.-I. Watanabe; A. Niwa; H. Fujino; H. Matsubara; S. Adachi; H. Suemori; T. Nakahata; T. Heike	T. Morishima; K.-I. Watanabe; A. Niwa; H. Fujino; H. Matsubara; S. Adachi; H. Suemori; T. Nakahata; T. Heike	Neutrophil differentiation from human-induced pluripotent stem cells	Neutrophil differentiation from human-induced pluripotent stem cells	Neutrophil differentiation from human-induced pluripotent stem cells	Journal of Cellular Physiology, 226, 5, 1283-1291	Journal of Cellular Physiology, 226, 5, 1283-1291	Journal of Cellular Physiology, 226, 5, 1283-1291	2011/05	有	英語	公開
A. Niwa; T. Heike; K. Umeda; K. Oshima; I. Kato; H. Sakai; H. Suemori; T. Nakahata; M.K. Saito	A. Niwa; T. Heike; K. Umeda; K. Oshima; I. Kato; H. Sakai; H. Suemori; T. Nakahata; M.K. Saito	A. Niwa; T. Heike; K. Umeda; K. Oshima; I. Kato; H. Sakai; H. Suemori; T. Nakahata; M.K. Saito	A novel Serum-Free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors	A novel Serum-Free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors	A novel Serum-Free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors	PLoS ONE, 6, 7, e22261	PLoS ONE, 6, 7, e22261	PLoS ONE, 6, 7, e22261	2011	有	英語	公開
I. Kato; A. Niwa; T. Heike; H. Fujino; M.K. Saito; K. Umeda; H. Hiramatsu; M. Ito; M. Morita; Y. Nishinaka; S. Adachi; F. Ishikawa; T. Nakahata	I. Kato; A. Niwa; T. Heike; H. Fujino; M.K. Saito; K. Umeda; H. Hiramatsu; M. Ito; M. Morita; Y. Nishinaka; S. Adachi; F. Ishikawa; T. Nakahata	I. Kato; A. Niwa; T. Heike; H. Fujino; M.K. Saito; K. Umeda; H. Hiramatsu; M. Ito; M. Morita; Y. Nishinaka; S. Adachi; F. Ishikawa; T. Nakahata	Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis	Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis	Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis	PLoS ONE, 6, 11, e27042	PLoS ONE, 6, 11, e27042	PLoS ONE, 6, 11, e27042	2011	有	英語	公開
Kato, Itaru; Niwa, Akira; Saito, Megumu; Fujino, Hisanori; Saida, Satoshi; Hiramatsu, Hidefumi; Oshima, Koichi; Ito, Mamoru; Adachi, Souichi; Heike, Toshio; Nakahata, Tatsutoshi	Kato, Itaru; Niwa, Akira; Saito, Megumu; Fujino, Hisanori; Saida, Satoshi; Hiramatsu, Hidefumi; Oshima, Koichi; Ito, Mamoru; Adachi, Souichi; Heike, Toshio; Nakahata, Tatsutoshi	Kato, Itaru; Niwa, Akira; Saito, Megumu; Fujino, Hisanori; Saida, Satoshi; Hiramatsu, Hidefumi; Oshima, Koichi; Ito, Mamoru; Adachi, Souichi; Heike, Toshio; Nakahata, Tatsutoshi	Establishment of a Novel CNS Infiltrated Xenograft Model through Engraftment of Patient-Derived Acute Lymphoblastic Leukemic Cells Into NOD/SCID/gamma c (Null) Mouse	Establishment of a Novel CNS Infiltrated Xenograft Model through Engraftment of Patient-Derived Acute Lymphoblastic Leukemic Cells Into NOD/SCID/gamma c (Null) Mouse	Establishment of a Novel CNS Infiltrated Xenograft Model through Engraftment of Patient-Derived Acute Lymphoblastic Leukemic Cells Into NOD/SCID/gamma c (Null) Mouse	BLOOD, 116, 21, 1332-1332	BLOOD, 116, 21, 1332-1332	BLOOD, 116, 21, 1332-1332	2010/11/19	有	英語	公開
T. Nakahata; T. Awaya; H. Chang; Y. Mizuno; A. Niwa; S.-I. Fukada; S. Takeda; S. Yamanaka; T. Heike	T. Nakahata; T. Awaya; H. Chang; Y. Mizuno; A. Niwa; S.-I. Fukada; S. Takeda; S. Yamanaka; T. Heike	T. Nakahata; T. Awaya; H. Chang; Y. Mizuno; A. Niwa; S.-I. Fukada; S. Takeda; S. Yamanaka; T. Heike	Derivation of Engraftable Myogenic Precursors from Murine ES/iPS cells and Generation of Disease-specific iPS cells from Patients with Duchenne Muscular dystrophy (DMD) and Other Diseases	Derivation of Engraftable Myogenic Precursors from Murine ES/iPS cells and Generation of Disease-specific iPS cells from Patients with Duchenne Muscular dystrophy (DMD) and Other Diseases	Derivation of Engraftable Myogenic Precursors from Murine ES/iPS cells and Generation of Disease-specific iPS cells from Patients with Duchenne Muscular dystrophy (DMD) and Other Diseases	Clinical Neurology, 50, 11, 889	Clinical Neurology, 50, 11, 889	Clinical Neurology, 50, 11, 889	2010/11	有	英語	公開
Y. Mizuno; H. Chang; K. Umeda; A. Niwa; T. Iwasa; T. Awaya; S.-I. Fukada; H. Yamamoto; S. Yamanaka; T. Nakahata; T. Heike	Y. Mizuno; H. Chang; K. Umeda; A. Niwa; T. Iwasa; T. Awaya; S.-I. Fukada; H. Yamamoto; S. Yamanaka; T. Nakahata; T. Heike	Y. Mizuno; H. Chang; K. Umeda; A. Niwa; T. Iwasa; T. Awaya; S.-I. Fukada; H. Yamamoto; S. Yamanaka; T. Nakahata; T. Heike	Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells	Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells	Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells	FASEB Journal, 24, 7, 2245-2253	FASEB Journal, 24, 7, 2245-2253	FASEB Journal, 24, 7, 2245-2253	2010/07	有	英語	公開
I. Kato; K. Umeda; T. Awaya; Y. Yui; A. Niwa; H. Fujino; H. Matsubara; K.-I. Watanabe; T. Heike; N. Adachi; F. Endo; T. Mizukami; H. Nunoi; T. Nakahata; S. Adachi	I. Kato; K. Umeda; T. Awaya; Y. Yui; A. Niwa; H. Fujino; H. Matsubara; K.-I. Watanabe; T. Heike; N. Adachi; F. Endo; T. Mizukami; H. Nunoi; T. Nakahata; S. Adachi	I. Kato; K. Umeda; T. Awaya; Y. Yui; A. Niwa; H. Fujino; H. Matsubara; K.-I. Watanabe; T. Heike; N. Adachi; F. Endo; T. Mizukami; H. Nunoi; T. Nakahata; S. Adachi	Successful treatment of refractory donor lymphocyte infusion-induced immune-mediated pancytopenia with rituximab	Successful treatment of refractory donor lymphocyte infusion-induced immune-mediated pancytopenia with rituximab	Successful treatment of refractory donor lymphocyte infusion-induced immune-mediated pancytopenia with rituximab	Pediatric Blood and Cancer, 54, 2, 329-331	Pediatric Blood and Cancer, 54, 2, 329-331	Pediatric Blood and Cancer, 54, 2, 329-331	2010/02	有	英語	公開
A. Niwa; K. Umeda; H. Chang; M. Saito; K. Okita; K. Takahashi; M. Nakagawa; S. Yamanaka; T. Nakahata; T. Heike	A. Niwa; K. Umeda; H. Chang; M. Saito; K. Okita; K. Takahashi; M. Nakagawa; S. Yamanaka; T. Nakahata; T. Heike	A. Niwa; K. Umeda; H. Chang; M. Saito; K. Okita; K. Takahashi; M. Nakagawa; S. Yamanaka; T. Nakahata; T. Heike	Orderly hematopoietic development of induced pluripotent stem cells via Flk-1<sup>+</sup> hemoangiogenic progenitors	Orderly hematopoietic development of induced pluripotent stem cells via Flk-1<sup>+</sup> hemoangiogenic progenitors	Orderly hematopoietic development of induced pluripotent stem cells via Flk-1<sup>+</sup> hemoangiogenic progenitors	Journal of Cellular Physiology, 221, 2, 367-377	Journal of Cellular Physiology, 221, 2, 367-377	Journal of Cellular Physiology, 221, 2, 367-377	2009/11	有	英語	公開
N. Yokoo; S. Baba; S. Kaichi; A. Niwa; T. Mima; H. Doi; S. Yamanaka; T. Nakahata; T. Heike	N. Yokoo; S. Baba; S. Kaichi; A. Niwa; T. Mima; H. Doi; S. Yamanaka; T. Nakahata; T. Heike	N. Yokoo; S. Baba; S. Kaichi; A. Niwa; T. Mima; H. Doi; S. Yamanaka; T. Nakahata; T. Heike	The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells	The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells	The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells	Biochemical and Biophysical Research Communications, 387, 3, 482-488	Biochemical and Biophysical Research Communications, 387, 3, 482-488	Biochemical and Biophysical Research Communications, 387, 3, 482-488	2009/09/25	有	英語	公開
M. Miyara; Y. Yoshioka; A. Kitoh; T. Shima; K. Wing; A. Niwa; C. Parizot; C. Taflin; T. Heike; D. Valeyre; A. Mathian; T. Nakahata; T. Yamaguchi; T. Nomura; M. Ono; Z. Amoura; G. Gorochov; S. Sakaguchi	M. Miyara; Y. Yoshioka; A. Kitoh; T. Shima; K. Wing; A. Niwa; C. Parizot; C. Taflin; T. Heike; D. Valeyre; A. Mathian; T. Nakahata; T. Yamaguchi; T. Nomura; M. Ono; Z. Amoura; G. Gorochov; S. Sakaguchi	M. Miyara; Y. Yoshioka; A. Kitoh; T. Shima; K. Wing; A. Niwa; C. Parizot; C. Taflin; T. Heike; D. Valeyre; A. Mathian; T. Nakahata; T. Yamaguchi; T. Nomura; M. Ono; Z. Amoura; G. Gorochov; S. Sakaguchi	Functional Delineation and Differentiation Dynamics of Human CD4<sup>+</sup> T Cells Expressing the FoxP3 Transcription Factor	Functional Delineation and Differentiation Dynamics of Human CD4<sup>+</sup> T Cells Expressing the FoxP3 Transcription Factor	Functional Delineation and Differentiation Dynamics of Human CD4<sup>+</sup> T Cells Expressing the FoxP3 Transcription Factor	Immunity, 30, 6, 899-911	Immunity, 30, 6, 899-911	Immunity, 30, 6, 899-911	2009/06/19	有	英語	公開
M. Kato; M. Sanada; I. Kato; Y. Sato; J. Takita; K. Takeuchi; A. Niwa; Y. Chen; K. Nakazaki; J. Nomoto; Y. Asakura; S. Muto; A. Tamura; M. Iio; Y. Akatsuka; Y. Hayashi; H. Mori; T. Igarashi; M. Kurokawa; S. Chiba; S. Mori; Y. Ishikawa; K. Okamoto; K. Tobinai; H. Nakagama; T. Nakahata; T. Yoshino; Y. Kobayashi; S. Ogawa	M. Kato; M. Sanada; I. Kato; Y. Sato; J. Takita; K. Takeuchi; A. Niwa; Y. Chen; K. Nakazaki; J. Nomoto; Y. Asakura; S. Muto; A. Tamura; M. Iio; Y. Akatsuka; Y. Hayashi; H. Mori; T. Igarashi; M. Kurokawa; S. Chiba; S. Mori; Y. Ishikawa; K. Okamoto; K. Tobinai; H. Nakagama; T. Nakahata; T. Yoshino; Y. Kobayashi; S. Ogawa	M. Kato; M. Sanada; I. Kato; Y. Sato; J. Takita; K. Takeuchi; A. Niwa; Y. Chen; K. Nakazaki; J. Nomoto; Y. Asakura; S. Muto; A. Tamura; M. Iio; Y. Akatsuka; Y. Hayashi; H. Mori; T. Igarashi; M. Kurokawa; S. Chiba; S. Mori; Y. Ishikawa; K. Okamoto; K. Tobinai; H. Nakagama; T. Nakahata; T. Yoshino; Y. Kobayashi; S. Ogawa	Frequent inactivation of A20 in B-cell lymphomas	Frequent inactivation of A20 in B-cell lymphomas	Frequent inactivation of A20 in B-cell lymphomas	Nature, 459, 7247, 712-716	Nature, 459, 7247, 712-716	Nature, 459, 7247, 712-716	2009/06/04	有	英語	公開
A.Y. Higashi; T. Ikawa; M. Muramatsu; A.N. Economides; A. Niwa; T. Okuda; A.J. Murphy; J. Rojas; T. Heike; T. Nakahata; H. Kawamoto; T. Kita; M. Yanagita	A.Y. Higashi; T. Ikawa; M. Muramatsu; A.N. Economides; A. Niwa; T. Okuda; A.J. Murphy; J. Rojas; T. Heike; T. Nakahata; H. Kawamoto; T. Kita; M. Yanagita	A.Y. Higashi; T. Ikawa; M. Muramatsu; A.N. Economides; A. Niwa; T. Okuda; A.J. Murphy; J. Rojas; T. Heike; T. Nakahata; H. Kawamoto; T. Kita; M. Yanagita	Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreER<sup>T2</sup>	Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreER<sup>T2</sup>	Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreER<sup>T2</sup>	Journal of Immunology, 182, 9, 5633-5640	Journal of Immunology, 182, 9, 5633-5640	Journal of Immunology, 182, 9, 5633-5640	2009/05/01	有	英語	公開
A. Niwa; K. Umeda; T. Awaya; Y. Yui; H. Matsubara; H. Hiramatsu; K.-I. Watanabe; S. Adachi; T. Itoh; S. Uemoto; T. Nakahata	A. Niwa; K. Umeda; T. Awaya; Y. Yui; H. Matsubara; H. Hiramatsu; K.-I. Watanabe; S. Adachi; T. Itoh; S. Uemoto; T. Nakahata	A. Niwa; K. Umeda; T. Awaya; Y. Yui; H. Matsubara; H. Hiramatsu; K.-I. Watanabe; S. Adachi; T. Itoh; S. Uemoto; T. Nakahata	Successful autologous peripheral blood stem cell transplantation with a double-conditioning regimen for recurrent hepatoblastoma after liver transplantation	Successful autologous peripheral blood stem cell transplantation with a double-conditioning regimen for recurrent hepatoblastoma after liver transplantation	Successful autologous peripheral blood stem cell transplantation with a double-conditioning regimen for recurrent hepatoblastoma after liver transplantation	Pediatric Transplantation, 13, 2, 259-262	Pediatric Transplantation, 13, 2, 259-262	Pediatric Transplantation, 13, 2, 259-262	2009/03	有	英語	公開
Makoto Miyara, Tomoko Shima, Akihiko Kitoh, Yumiko Yosioka, Akira Niwa, Cecile Taflin, Toshio Heike, DominiqueValeyre, Alexis Mathian, Zahir Amoura, Tatsutoshi Nakahata, Tomoyuki Yamaguchi, Takashi Nomura Kajsa Wing, Guy Gorochov, Masahiro Ono ,Shimon Sakaguchi	Makoto Miyara, Tomoko Shima, Akihiko Kitoh, Yumiko Yosioka, Akira Niwa, Cecile Taflin, Toshio Heike, DominiqueValeyre, Alexis Mathian, Zahir Amoura, Tatsutoshi Nakahata, Tomoyuki Yamaguchi, Takashi Nomura Kajsa Wing, Guy Gorochov, Masahiro Ono ,Shimon Sakaguchi	Makoto Miyara, Tomoko Shima, Akihiko Kitoh, Yumiko Yosioka, Akira Niwa, Cecile Taflin, Toshio Heike, DominiqueValeyre, Alexis Mathian, Zahir Amoura, Tatsutoshi Nakahata, Tomoyuki Yamaguchi, Takashi Nomura Kajsa Wing, Guy Gorochov, Masahiro Ono ,Shimon Sakaguchi	Functional delineation and differentiation dynamics \nof FoxP3-expressing subpopulation of CD4＋ T cell in humans	Functional delineation and differentiation dynamics \nof FoxP3-expressing subpopulation of CD4＋ T cell in humans	Functional delineation and differentiation dynamics \nof FoxP3-expressing subpopulation of CD4＋ T cell in humans	World Immune Regulation Meeting-II (2008.3.17-20 Davos Switzerland)	World Immune Regulation Meeting-II (2008.3.17-20 Davos Switzerland)	World Immune Regulation Meeting-II (2008.3.17-20 Davos Switzerland)	2008	有	英語	公開
H. Fujino; H. Hiramatsu; A. Tsuchiya; A. Niwa; H. Noma; M. Shiota; K. Umeda; M. Yoshimoto; M. Ito; T. Heike; T. Nakahata	H. Fujino; H. Hiramatsu; A. Tsuchiya; A. Niwa; H. Noma; M. Shiota; K. Umeda; M. Yoshimoto; M. Ito; T. Heike; T. Nakahata	H. Fujino; H. Hiramatsu; A. Tsuchiya; A. Niwa; H. Noma; M. Shiota; K. Umeda; M. Yoshimoto; M. Ito; T. Heike; T. Nakahata	Human cord blood CD34<sup>+</sup> cells develop into hepatocytes in the livers of NOD/SCID/γ<sub>c</sub><sup>null</sup> mice through cell fusion	Human cord blood CD34<sup>+</sup> cells develop into hepatocytes in the livers of NOD/SCID/γ<sub>c</sub><sup>null</sup> mice through cell fusion	Human cord blood CD34<sup>+</sup> cells develop into hepatocytes in the livers of NOD/SCID/γ<sub>c</sub><sup>null</sup> mice through cell fusion	FASEB Journal, 21, 13, 3499-3510	FASEB Journal, 21, 13, 3499-3510	FASEB Journal, 21, 13, 3499-3510	2007/11	有	英語	公開
H. Matsubara; M. Kobayashi; Y. Yui; I. Kato; A. Niwa; M. Arai; M. Miyazaki; Y. Mizushima; K. Umeda; H. Hiramatsu; K. Watanabe; S. Adachi; T. Nakahata	H. Matsubara; M. Kobayashi; Y. Yui; I. Kato; A. Niwa; M. Arai; M. Miyazaki; Y. Mizushima; K. Umeda; H. Hiramatsu; K. Watanabe; S. Adachi; T. Nakahata	Matsubara H, Kobayashi M, Yui Y, Kato I, Niwa A, Arai M, Miyazaki M, Mizushima Y, Umeda K, Hiramatsu H, Watanabe K, Adachi S, Nakahata T	Continuous infusion of cyclosporine A and C3 monitoring in pediatric stem cell transplantation	Continuous infusion of cyclosporine A and C3 monitoring in pediatric stem cell transplantation	[Continuous infusion of cyclosporine A and C3 monitoring in pediatric stem cell transplantation].	[Rinshō ketsueki] The Japanese journal of clinical hematology, 48, 8, 605-610	[Rinshō ketsueki] The Japanese journal of clinical hematology, 48, 8, 605-610	[Rinsho ketsueki] The Japanese journal of clinical hematology, 48, 8, 605-610	2007/08	有	日本語	公開
A. Niwa; H. Matsubara; S. Adachi; H. Fujino; Y. Higashi; K. Umeda; M. Shiota; H. Hiramatsu; M. Kobayashi; K.-I. Watanabe; T. Yorifuji; T. Nakahata	A. Niwa; H. Matsubara; S. Adachi; H. Fujino; Y. Higashi; K. Umeda; M. Shiota; H. Hiramatsu; M. Kobayashi; K.-I. Watanabe; T. Yorifuji; T. Nakahata	A. Niwa; H. Matsubara; S. Adachi; H. Fujino; Y. Higashi; K. Umeda; M. Shiota; H. Hiramatsu; M. Kobayashi; K.-I. Watanabe; T. Yorifuji; T. Nakahata	Diabetes mellitus after stem cell transplantation in a patient with acute lymphoblastic leukemia: Possible association with tacrolimus	Diabetes mellitus after stem cell transplantation in a patient with acute lymphoblastic leukemia: Possible association with tacrolimus	Diabetes mellitus after stem cell transplantation in a patient with acute lymphoblastic leukemia: Possible association with tacrolimus	Pediatrics International, 49, 4, 530-532	Pediatrics International, 49, 4, 530-532	Pediatrics International, 49, 4, 530-532	2007/08	有	英語	公開
G. Shinoda; K. Umeda; T. Heike; M. Arai; A. Niwa; F. Ma; H. Suemori; Y.L. Hong; D.H.K. Chui; R. Torii; M. Shibuya; N. Nakatsuji; T. Nakahata	G. Shinoda; K. Umeda; T. Heike; M. Arai; A. Niwa; F. Ma; H. Suemori; Y.L. Hong; D.H.K. Chui; R. Torii; M. Shibuya; N. Nakatsuji; T. Nakahata	G. Shinoda; K. Umeda; T. Heike; M. Arai; A. Niwa; F. Ma; H. Suemori; Y.L. Hong; D.H.K. Chui; R. Torii; M. Shibuya; N. Nakatsuji; T. Nakahata	α4-Integrin<sup>+</sup> endothelium derived from primate embryonic stem cells generates primitive and definitive hematopoietic cells	α4-Integrin<sup>+</sup> endothelium derived from primate embryonic stem cells generates primitive and definitive hematopoietic cells	α4-Integrin<sup>+</sup> endothelium derived from primate embryonic stem cells generates primitive and definitive hematopoietic cells	Blood, 109, 6, 2406-2415	Blood, 109, 6, 2406-2415	Blood, 109, 6, 2406-2415	2007/03	有	英語	公開
K. Umeda; T. Heike; M. Nakata-Hizume; A. Niwa; M. Arai; G. Shinoda; F. Ma; H. Suemori; Y.L. Hong; D.H.K. Chui; R. Torii; M. Shibuya; N. Nakatsuji; T. Nakahata	K. Umeda; T. Heike; M. Nakata-Hizume; A. Niwa; M. Arai; G. Shinoda; F. Ma; H. Suemori; Y.L. Hong; D.H.K. Chui; R. Torii; M. Shibuya; N. Nakatsuji; T. Nakahata	K. Umeda; T. Heike; M. Nakata-Hizume; A. Niwa; M. Arai; G. Shinoda; F. Ma; H. Suemori; Y.L. Hong; D.H.K. Chui; R. Torii; M. Shibuya; N. Nakatsuji; T. Nakahata	Sequential analysis of α- and β-globin gene expression during erythropoietic differentiation from primate embryonic stem cells	Sequential analysis of α- and β-globin gene expression during erythropoietic differentiation from primate embryonic stem cells	Sequential analysis of α- and β-globin gene expression during erythropoietic differentiation from primate embryonic stem cells	Stem Cells, 24, 12, 2627-2636	Stem Cells, 24, 12, 2627-2636	Stem Cells, 24, 12, 2627-2636	2006/12	有	英語	公開
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Misc

著者	著者(日本語)	著者(英語)	タイトル	タイトル(日本語)	タイトル(英語)	書誌情報等	書誌情報等(日本語)	書誌情報等(英語)	出版年月	査読の有無	記述言語	公開
高田穣,平明日香,鈴木直也,丹羽明,中畑龍俊,矢部普正,斉藤潤,松尾恵太郎,矢部みはる	高田穣,平明日香,鈴木直也,丹羽明,中畑龍俊,矢部普正,斉藤潤,松尾恵太郎,矢部みはる		“ファンコニ貧血経路とアルデヒド代謝の遺伝的相互作用解析”	“ファンコニ貧血経路とアルデヒド代謝の遺伝的相互作用解析”		第35 回日本分子生物学会年会　ポスターよりワークショップへ採択　2012年12月	第35 回日本分子生物学会年会　ポスターよりワークショップへ採択　2012年12月		2012	有	日本語	公開
Minora Takata, Asuka Hira, Naoya Suzuki, Akira Niwa, Tatsutoshi Nalcahata, Hiromasa Yabe, Megumu K. Saito, Keitaro Matsuo, Miharu Yabe	Minora Takata, Asuka Hira, Naoya Suzuki, Akira Niwa, Tatsutoshi Nalcahata, Hiromasa Yabe, Megumu K. Saito, Keitaro Matsuo, Miharu Yabe	Minora Takata, Asuka Hira, Naoya Suzuki, Akira Niwa, Tatsutoshi Nalcahata, Hiromasa Yabe, Megumu K. Saito, Keitaro Matsuo, Miharu Yabe	Genetic interplay between the Fanconi anemia pathway and aldehyde metabolism in humans	Genetic interplay between the Fanconi anemia pathway and aldehyde metabolism in humans	Genetic interplay between the Fanconi anemia pathway and aldehyde metabolism in humans	28th RBC-NIRS INTERNATIONAL SYMPOSIUM Nov 2012, 京都	28th RBC-NIRS INTERNATIONAL SYMPOSIUM Nov 2012, 京都	28th RBC-NIRS INTERNATIONAL SYMPOSIUM Nov 2012, 京都	2012	有	英語	公開
Y. Kuroda; M. Kitada; S. Wakao; K. Nishikawa; Y. Tanimura; H. Makinoshima; M. Goda; H. Akashi; A. Inutsuka; A. Niwa; T. Shigemoto; Y. Nabeshima; T. Nakahata; Y.-I. Nabeshima; Y. Fujiyoshi; M. Dezawa	Y. Kuroda; M. Kitada; S. Wakao; K. Nishikawa; Y. Tanimura; H. Makinoshima; M. Goda; H. Akashi; A. Inutsuka; A. Niwa; T. Shigemoto; Y. Nabeshima; T. Nakahata; Y.-I. Nabeshima; Y. Fujiyoshi; M. Dezawa	Y. Kuroda; M. Kitada; S. Wakao; K. Nishikawa; Y. Tanimura; H. Makinoshima; M. Goda; H. Akashi; A. Inutsuka; A. Niwa; T. Shigemoto; Y. Nabeshima; T. Nakahata; Y.-I. Nabeshima; Y. Fujiyoshi; M. Dezawa	Unique multipotent cells in adult human mesenchymal cell populations	Unique multipotent cells in adult human mesenchymal cell populations	Unique multipotent cells in adult human mesenchymal cell populations	Proceedings of the National Academy of Sciences of the United States of America, 107, 19, 8639-8643	Proceedings of the National Academy of Sciences of the United States of America, 107, 19, 8639-8643	Proceedings of the National Academy of Sciences of the United States of America, 107, 19, 8639-8643	2010/05/11	有	英語	公開
丹羽明,斎藤潤,加藤格,大嶋宏一,百瀬大,高橋和利,末盛博文,中辻憲夫,山中伸弥,平家俊男,中畑龍俊	丹羽明,斎藤潤,加藤格,大嶋宏一,百瀬大,高橋和利,末盛博文,中辻憲夫,山中伸弥,平家俊男,中畑龍俊		ヒトES/iPS 細胞からの試験管内造血系を用いた分化過程の解析	ヒトES/iPS 細胞からの試験管内造血系を用いた分化過程の解析		第9 回日本再生医療医学会総会（2010.3.19 広島）	第9 回日本再生医療医学会総会（2010.3.19 広島）		2010	有	日本語	公開
タイトル言語:

外部資金：競争的資金・科学研究費補助金

種別	代表/分担	テーマ(日本語)	期間
若手研究（B）		ヒトＥＳ／ｉＰＳ細胞からの造血幹細胞及び機能的赤血球の誘導	2010〜2011
若手研究（Ｂ）	代表	ヒトES/iPS細胞への順遺伝学的手法適用による、白血病の新規発症機序解明	2013〜2014
若手研究（Ｂ）	代表	ヒトES/iPS細胞への順遺伝学的手法適用による、白血病の新規発症機序解明（平成26年度分）	2014/04/01〜2015/03/31
基盤研究(C)	代表	内在性変異導入分子による白血病クローン多様性獲得機構の解明（平成28年度分）	2016/04/01〜2017/03/31
基盤研究(C)	代表	内在性変異導入分子による白血病クローン多様性獲得機構の解明（平成29年度分）	2017/04/01〜2018/03/31

全学運営（役職等）

役職名	期間
環境管理専門委員会有機廃液情報管理小委員会	2018/04/01〜2020/03/31

部局運営（役職等）

役職名	期間
動物実験委員会	2016/04/01〜2018/03/31

丹羽 明

丹羽明