岩井 一宏

最終更新日時: 2019/06/18 17:20:29

印刷する

氏名(漢字/フリガナ/アルファベット表記)
岩井 一宏/イワイ カズヒロ/Iwai, Kazuhiro
所属部署・職名(部局/所属/講座等/職名)
医学研究科/医学専攻生体制御医学講座細胞機能制御学/教授
学部兼担
部局 所属 講座等 職名
医学部
連絡先住所
種別 住所(日本語) 住所(英語)
職場 〒606-8501 京都市左京区吉田近衛町 Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University Yoshida-konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
連絡先電話番号
種別 番号
職場 075-753-4671
電子メールアドレス
メールアドレス
kiwai @ mcp.med.kyoto-u.ac.jp
所属学会(国内)
学会名(日本語) 学会名(英語)
日本生化学会 The Japanese Biochemical Society
日本分子生物学会 The Molecular Biology Society of Japan
日本癌学会 Japanese Cancer Association
日本細胞生物学会 Japan Society of Cell Biology
日本鉄バイオサイエンス学会 The Japan Bio Iron Society
日本病態プロテアーゼ学会 Japan Society for Proteases in Pathophysiology
所属学会(海外)
学会名(英語) 国名
The American Society for Biochemistry and Molecular Biology 米国
American Society for Microbiology 米国
The American Association of Immunologists 米国
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
博士(医学) Doctor of Medical Science (equivalent to Ph. D) 京都大学 Kyoto University
出身大学院・研究科等
大学名(日本語) 大学名(英語) 研究科名(日本語) 研究科名(英語) 専攻名(日本語) 専攻名(英語) 修了区分
京都大学 Kyoto University 大学院医学研究科博士課程内科系専攻 Graduate School of Medicine Internal Medicine 研究指導認定退学
京都大学 Kyoto University 大学院医学研究科博士課程内科系専攻 Graduate School of Medicine Internal Medicine 修了
出身学校・専攻等
大学名(日本語) 大学名(英語) 学部名(日本語) 学部名(英語) 学科名(日本語) 学科名(英語) 卒業区分
京都大学 Kyoto University 医学部医学科 Faculty of Medicine 卒業
京都大学 Kyoto University 医学部医学進学課程 修了
職歴
期間 組織名(日本語) 組織名(英語) 職名(日本語) 職名(英語)
1985/06/01〜1987/03/31 神戸市立中央市民病院 Kobe General Hospital, Kobe, Japan 内科研修医 Resident physician
1992/10/1〜1993/03/31 京都大学医学部 Faculty of Medicine, Kyoto University, Kyoto, Japan 助手 Instructor
1993/04/01〜1996/03/28 米国国立保健研究所 National Institute of Child Health and Human Development, National Institutes of Health, USA 研究員 Visiting Fellow
1996/03/29〜1997/05/31 京都大学大学院医学研究科 Graduate School of Medicine, Kyoto University, Japan 助手 Assistant Professor
1997/06/01〜1999/03/31 京都大学大学院医学研究科 Graduate School of Medicine, Kyoto University, Japan 助教授 Associate Professor
1999/04/01〜2001/06/30 京都大学大学院生命科学研究科 Graduate School of Biostudies, Kyoto University, Japan 助教授 Associate Professor
2001/07/01〜2008/03/31 大阪市立大学大学院医学研究科 Graduate School of Medicine, Osaka City University, Japan 教授 Professor
2008/04/01〜2012/03/31 大阪大学大学院生命機能研究科/医学系研究科 Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Japan 教授 Professor
2012/04/01〜 京都大学大学院医学研究科 Graduate School of Medicine, Kyoto University, Japan 教授 Professor
ORCID ID
https://orcid.org/0000-0001-5620-5951
researchmap URL
https://researchmap.jp/read0069526
研究テーマ
(日本語)
ユビキチン修飾系による生体制御機構 ユビキチン系の破綻による炎症性疾患、がんの発症機構 ユビキチン修飾系によるNF-kappaB活性化、細胞死抑制機構 鉄代謝調節機構
(英語)
ubiquitin conjugation system Involvement of the ubiquitin system in the pathogenesis of inflammatory diseases and cancer Roles of the ubiquitin system played in NF-kappaB activation and cell death protection Iron metabolism
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
ユビキチン ubiquitin
NF-kappaB NF-kappaB
鉄代謝 iron metabolism
直鎖状ポリユビキチン鎖 linear polyubiquitination
細胞死抑制 Cell death protection
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
岩井 一宏 岩井 一宏 Iwai K. Regulation of cellular iron metabolism: Iron-dependent degradation of IRP by SCFFBXL5 ubiquitin ligase. Regulation of cellular iron metabolism: Iron-dependent degradation of IRP by SCFFBXL5 ubiquitin ligase. Regulation of cellular iron metabolism: Iron-dependent degradation of IRP by SCFFBXL5 ubiquitin ligase. Free Radic. Biol. Med., 133, 64-68 Free Radic. Biol. Med., 133, 64-68 Free Radic. Biol. Med., 133, 64-68 2019/03 英語 研究論文(学術雑誌) 公開
Wu, M., Chang, Y., Hu, H., Mu, R., Zhang, Y., Qin, X., Duan, X., Li, W., Tu, H., Zhang, W., Wang, G., Han, Q., Li, A., Zhou, T., Iwai, K., Zhang, X. and Li, H. Wu, M., Chang, Y., Hu, H., Mu, R., Zhang, Y., Qin, X., Duan, X., Li, W., Tu, H., Zhang, W., Wang, G., Han, Q., Li, A., Zhou, T., Iwai, K., Zhang, X. and Li, H. LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores. LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores. LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores. Nature Commun., 10, 1 Nature Commun., 10, 1 Nature Commun., 10, 1 2019/01 英語 研究論文(学術雑誌) 公開
MacDuff, D.A., Baldridge, M.T., Qaqish, A.M., Nice, T.J., Darbandi, A.D., Hartley, V.L., Peterson, S.T., Miner, J.J., Iwai, K. and Virgin, H.W. MacDuff, D.A., Baldridge, M.T., Qaqish, A.M., Nice, T.J., Darbandi, A.D., Hartley, V.L., Peterson, S.T., Miner, J.J., Iwai, K. and Virgin, H.W. HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection. HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection. HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection. J. Virol., 92, 23 J. Virol., 92, 23 J. Virol., 92, 23 2018/12 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Sasaki, Y. and Iwai, K. Crucial role of LUBAC-mediated inhibition of programmed cell death in TLR4-mediated B cell responses and B1b cell development. Crucial role of LUBAC-mediated inhibition of programmed cell death in TLR4-mediated B cell responses and B1b cell development. Crucial role of LUBAC-mediated inhibition of programmed cell death in TLR4-mediated B cell responses and B1b cell development. J. Immunol., 200, 10, 3438-3449 J. Immunol., 200, 10, 3438-3449 J. Immunol., 200, 10, 3438-3449 2018/04 英語 研究論文(学術雑誌) 公開
Fujita, H., Tokunaga, A., Shimizu, S., Whiting, A. L., Aguilar-Alonso, F., Takagi, K., Walinda, E., Sasaki, Y., Shimokawa, T., Mizushima, T., Ohki, I., Ariyoshi, M., Tochio, H., Bernal, F., Shirakawa, M., and Iwai, K. Fujita, H., Tokunaga, A., Shimizu, S., Whiting, A. L., Aguilar-Alonso, F., Takagi, K., Walinda, E., Sasaki, Y., Shimokawa, T., Mizushima, T., Ohki, I., Ariyoshi, M., Tochio, H., Bernal, F., Shirakawa, M., and Iwai, K. Cooperative domain formation by homologous motifs in HOIL-1L and SHARPIN plays crucial roles in LUBAC stabilization. Cooperative domain formation by homologous motifs in HOIL-1L and SHARPIN plays crucial roles in LUBAC stabilization. Cooperative domain formation by homologous motifs in HOIL-1L and SHARPIN plays crucial roles in LUBAC stabilization. Cell Reports, 23, 4, 1192-1204 Cell Reports, 23, 4, 1192-1204 Cell Reports, 23, 4, 1192-1204 2018/04 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Kaji, S., Maki, T., Kinoshita, H., Uemura, N., Ayaki, T., Kawamoto, Y., Furuta, T., Urushitani, M., Hasegawa, M., Kinoshita, Y., Ono, Y., Mao, X., Quach, T.H., Iwai, K., Dawson, V.L., Dawson, T.M., and Takahashi, R. Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy. Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy. Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy. Stem Cell Reports, 10, 2, 356-365 Stem Cell Reports, 10, 2, 356-365 Stem Cell Reports, 10, 2, 356-365 2018/02 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Ogura, M., Endo, R., Ishikawa, H., Takeda, Y., Uchida, T., Iwai, K., Kobayashi, K., and Ishimori, K. Redox-dependent axial ligand replacement and its functional significance in heme-bound iron regulatory proteins. Redox-dependent axial ligand replacement and its functional significance in heme-bound iron regulatory proteins. Redox-dependent axial ligand replacement and its functional significance in heme-bound iron regulatory proteins. J. Inorg. Biochem., 182, 238-248 J. Inorg. Biochem., 182, 238-248 J. Inorg. Biochem., 182, 238-248 2018/02 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Tamiya, H., Kim, H., Klymenko, O., Kim, H., Feng, Y., Zhang, T., Han, J.Y., Murao, A., Snipas, S.J., Jilaveanu, L., Brown, K., Kluger, H., Zhang, H., Iwai, K., and Ronai, Z.A. SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth. SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth. SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth. J. Clin. Invest., 128, 1, 517-530 J. Clin. Invest., 128, 1, 517-530 J. Clin. Invest., 128, 1, 517-530 2018/01 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Magnani, N.D., Dada, D.A., Queisser, M,A., Brazee, P., Welch, L,C., Anekalla, K., Zhou, G., Misharin, A., Budinger, G.R.S., Iwai, K., Ciechanover, A.J., and Sznajder J.I. HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury. HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury. HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury. Proc. Natl. Acad. Sci. USA., 114, 47, 10178-10186 Proc. Natl. Acad. Sci. USA., 114, 47, 10178-10186 Proc. Natl. Acad. Sci. USA., 114, 47, 10178-10186 2017/11 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Yoshida, Y., Yasuda, S., Fujita, T., Hamasak,i M., Murakami, A., Kawawaki, J., Iwai, K., Saeki, Y., Yoshimori, T., Matsuda, N., and Tanaka, K. Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy. Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy. Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy. Proc. Natl. Acad. Sci. USA., 114, 32, 8574-8579 Proc. Natl. Acad. Sci. USA., 114, 32, 8574-8579 Proc. Natl. Acad. Sci. USA., 114, 32, 8574-8579 2017/07 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Shibata, Y., Tokunaga, F., Goto, E., Komatsu, G., Gohda, J., Saeki, Y., Tanaka, K., Takahashi, H., Sawasaki, T., Inoue, S., Oshiumi, H., Seya, T., Nakano, H., Tanaka, Y., Iwai, K., and Inoue, J.I. HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains. HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains. HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains. PLoS Pathog., 13, e1006162. PLoS Pathog., 13, e1006162. PLoS Pathog., 13, e1006162. 2017 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Nakazawa, S., Oikawa, D., Ishii, R., Ayaki, T., Takahashi, H., Takeda, H., Ishitani, R., Kamei, K., Takeyoshi, I., Kawakami, H., Iwai, K., Hatada, I., Sawasaki, T., Ito, H., Nureki, O., and Tokunaga, F. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun., 7, 12547 Nat Commun., 7, 12547 Nat Commun., 7, 12547 2016/08 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Kitatsuji, C., Izumi, K., Nambu, S., Kurogochi, M., Uchida, T., Nishimura, S., Iwai, K., O'Brian, M. R., Ikeda-Saito, M., and Ishimori, K. Protein oxidation mediated by heme-induced active site conversion specific for heme-regulated transcription factor, iron response regulator. Protein oxidation mediated by heme-induced active site conversion specific for heme-regulated transcription factor, iron response regulator. Protein oxidation mediated by heme-induced active site conversion specific for heme-regulated transcription factor, iron response regulator. Sci. Rep., 6, 18703 Sci. Rep., 6, 18703 Sci. Rep., 6, 18703 2016 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Morita, D., Yamamoto, Y., Mizutani, T., Ishikawa, T., Suzuki, J., Igarashi, T., Mori, N., Shiina, T., Inoko, H., Fujita, H., Iwai, K., Tanaka, Y., Mikami, B., and Sugita, M. Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex. Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex. Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex. Nat. Commun., 7, 10356. Nat. Commun., 7, 10356. Nat. Commun., 7, 10356. 2016 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Shimizu, S., Fujita, H., Sasaki, Y., Tsuruyama, T., Fukuda, K., and Iwai, K. Differential involvement of the NZF domains of SHARPIN and HOIL-1L in LUBAC-mediated cell death protection. Differential involvement of the NZF domains of SHARPIN and HOIL-1L in LUBAC-mediated cell death protection. Differential involvement of the NZF domains of SHARPIN and HOIL-1L in LUBAC-mediated cell death protection. Mol. Cell. Biol., 36, 1569-1583 Mol. Cell. Biol., 36, 1569-1583 Mol. Cell. Biol., 36, 1569-1583 2016 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Sasaki, Y. and Iwai, K. Roles of the NF-κB Pathway in B-Lymphocyte Biology. Roles of the NF-κB Pathway in B-Lymphocyte Biology. Roles of the NF-κB Pathway in B-Lymphocyte Biology. Curr. Top. Microbiol. Immunol., 393, 177-209 Curr. Top. Microbiol. Immunol., 393, 177-209 Curr. Top. Microbiol. Immunol., 393, 177-209 2016 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Kobayashi, K., Nakagaki, M., Ishikawa, H., Iwai, K., O'Brian, M.R., and Ishimori, K. Redox-Dependent Dynamics in Heme-Bound Bacterial Iron Response Regulator (Irr) Protein. Redox-Dependent Dynamics in Heme-Bound Bacterial Iron Response Regulator (Irr) Protein. Redox-Dependent Dynamics in Heme-Bound Bacterial Iron Response Regulator (Irr) Protein. Biochemistry, 55, 29, 4047-4054 Biochemistry, 55, 29, 4047-4054 Biochemistry, 55, 29, 4047-4054 2016 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Yamano, Y., Sugimoto, M., Hirayama, A., Kume, S., Yamato, M., Jin, G., Tajima, S., Goda, N., Iwai, K., Fukuda, S., Yamaguti, K., Kuratsune, H., Soga, T., Watanabe, Y., and Kataoka, Y. Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles Sci. Rep., 6, 34990 Sci. Rep., 6, 34990 Sci. Rep., 6, 34990 2016 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Okamura, K., Kitamura, A., Sasaki, Y., Chung, D.H., Kagami, S., Iwai, K., and Yasutomo, K. Survival of mature T cells depends on signaling through HOIP. Survival of mature T cells depends on signaling through HOIP. Survival of mature T cells depends on signaling through HOIP. Sci. Rep., 6, 36135 Sci. Rep., 6, 36135 Sci. Rep., 6, 36135 2016 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Zhao, Y., Ma, C. A., Wu, L., Iwai, K., Ashwell, J. D., Oltz, E. M., Ballard, D. W., and Jain, A. CYLD and the NEMO zinc finger regulate tumor necrosis factor signaling and early embryogenesis. CYLD and the NEMO zinc finger regulate tumor necrosis factor signaling and early embryogenesis. CYLD and the NEMO zinc finger regulate tumor necrosis factor signaling and early embryogenesis. J. Biol. Chem., 290, 36, 22076-22084 J. Biol. Chem., 290, 36, 22076-22084 J. Biol. Chem., 290, 36, 22076-22084 2015 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Kumanomidou, T., Nishio, K., Takagi, K., Nakagawa, T., Suzuki, A., Yamane, T., Tokunaga, F., Iwai, K., Murakami, A., Yoshida, Y., Tanaka, K., and Mizushima, T. The Structural differences between a glycoprotein specific F-Box protein Fbs1 and its homologous protein FBG3. The Structural differences between a glycoprotein specific F-Box protein Fbs1 and its homologous protein FBG3. The Structural differences between a glycoprotein specific F-Box protein Fbs1 and its homologous protein FBG3. PLoS One, 10, 10, e0140366 PLoS One, 10, 10, e0140366 PLoS One, 10, 10, e0140366 2015 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Bowman, J., Rodgers, M.A., Shi, M., Amatya, R., Hostager, B., Iwai, K., Gao, S.J., and Jung, J.U. Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation. Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation. Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation. MBio., 6, 6, e01777-15 MBio., 6, 6, e01777-15 MBio., 6, 6, e01777-15 2015 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 15. Sasaki, K. and Iwai, K. Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system. Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system. Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system. Immunol. Rev., 266, 1, 175-189 Immunol. Rev., 266, 1, 175-189 Immunol. Rev., 266, 1, 175-189 2015 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Asano, T., Koike, M., akata, S.-I., Takeda, Y., Nakagawa, T., Hatano, T., Ohashi, S., Funayama, M., Yoshimi, K., Asanuma, M., Toyokuni, S., Mochizuki, H., Uchiyama, Y., Hattori, N., and Iwai, K. Possible involvement of iron-induced oxidative insults in neurodegeneration Possible involvement of iron-induced oxidative insults in neurodegeneration Possible involvement of iron-induced oxidative insults in neurodegeneration Neurosci. Lett., 588, 29-35 Neurosci. Lett., 588, 29-35 Neurosci. Lett., 588, 29-35 2015 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Morimoto, D., Walinda, E., Fukada, H., Sou, Y. S., Kageyama, S., Hoshino, M., Fujii, T., Tsuchiya, H., Saeki, Y., Arita, K., Ariyoshi, M., Tochio, H., Iwai, K., Namba, K., Komatsu, M., Tanaka, K., Shirakawa, M. The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates. The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates. The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates. Nat. Commun., 6, 6116 Nat. Commun., 6, 6116 Nat. Commun., 6, 6116 2015 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 MacDuff, D. A., Reese, T. A,, Kimmey, J. M., Weiss, L. A., Song, C., Zhang, X., Kambal, A., Duan, E., Carrero, J. A., Boisson, B., Laplantine, E., Israel, A., Picard, C., Colonna, M., Edelson, B. T., Sibley, L. D., Stallings, C. L., Casanova, J. L., Iwai, K., Virgin, H. W. Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection. Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection. Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection. eLife, 4, e04494 eLife, 4, e04494 eLife, 4, e04494 2015 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Sakamoto, H., Egashira, S., Saito, N., Kirisako, T., Miller, S., Sasaki, Y., Matsumoto, T., Shimonishi, M., Komatsu, T., Terai, T., Ueno, T., Hanaoka, K., Kojima, H., Okabe, T., Wakatsuki, S., Iwai, K., (corresponding author) and Nagano, T. Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC). Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC). Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC). ACS Chem. Biol. ACS Chem. Biol. ACS Chem. Biol. 2014/12 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Yang, Y., Schmitz, R., Mitala, J. J. Jr., Whiting, A., Xiao, W., Ceribelli, M., Wright, G. W., Zhao, H., Yang, Y., Xu, W., Rosenwald, A., Ott, G., Gascoyne, R. D., Connors, J. M., Rimsza, L. M., Campo, E., Jaffe, E. S., Delabie, J., Smeland, E. B., Braziel, R. M., Tubbs, R. R., Cook, J. R., Weisenburger, D. D., Chan, W. C., Wiestner, A., Kruhlak, M. J., Iwai, K., Bernal, F., and Staudt, L. M. Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms. Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms. Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms. Cancer Discov., 4, 4, 480-493 Cancer Discov., 4, 4, 480-493 Cancer Discov., 4, 4, 480-493 2014 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Tamiya H, Terao M, Takiuchi T, Nakahara M, Sasaki Y, Katayama I, Yoshikawa H, and Iwai K. IFN-γ or IFN-α ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex. IFN-γ or IFN-α ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex. IFN-γ or IFN-α ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex. J. Immunol., 192, 3793-3804 J. Immunol., 192, 3793-3804 J. Immunol., 192, 3793-3804 2014 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Rodgers, M. A., Bowman, J., Fujita, H., Orazio, N., Shi, M., Liang, Q., Amatya, R., Kelly, T. J., Iwai, K., Ting, J., and Jung, J. U. The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation. The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation. The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation. J. Exp. Med., 211, 1333-1347 J. Exp. Med., 211, 1333-1347 J. Exp. Med., 211, 1333-1347 2014 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Queisser, M. A., Dada, L. A., Deiss-Yehiely, N., Angulo, M., Zhou, G., Kouri, F. M., Knab, L. M., Liu, J., Stegh, A. H., DeCamp, M. M., Budinger, G. R., Chandel, N. S., Ciechanover, A., Iwai, K., and Sznajder, J. I. HOIL-1L Functions as the PKCζ Ubiquitin Ligase to Promote Lung Tumor Growth. HOIL-1L Functions as the PKCζ Ubiquitin Ligase to Promote Lung Tumor Growth. HOIL-1L Functions as the PKCζ Ubiquitin Ligase to Promote Lung Tumor Growth. Am. J. Respir. Crit. Care Med., 190, 688-698 Am. J. Respir. Crit. Care Med., 190, 688-698 Am. J. Respir. Crit. Care Med., 190, 688-698 2014 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Iwai, K., Fujita, H., and Sasaki, Y. Linear ubiquitin chains: NF-κB signalling, cell death, and beyond. Linear ubiquitin chains: NF-κB signalling, cell death, and beyond. Linear ubiquitin chains: NF-κB signalling, cell death, and beyond. Nature Rev. Mol. Cell Biol., 15, 8, 503-508 Nature Rev. Mol. Cell Biol., 15, 8, 503-508 Nature Rev. Mol. Cell Biol., 15, 8, 503-508 2014 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 Iwai, K. and Tanaka, K. Ubiquitin chain elongation: An intriguing strategy. Ubiquitin chain elongation: An intriguing strategy. Ubiquitin chain elongation: An intriguing strategy. Molecular Cell, 56, 2, 189-191 Molecular Cell, 56, 2, 189-191 Molecular Cell, 56, 2, 189-191 2014 英語 研究論文(学術雑誌) 公開
K. Iwai; F. Tokunaga K. Iwai; F. Tokunaga Linear polyubiquitination: A new regulator of NF-κB activation Linear polyubiquitination: A new regulator of NF-κB activation EMBO Reports, 10, 7, 706-713 EMBO Reports, 10, 7, 706-713 , 10, 7, 706-713 2009 日本語 公開
岩井 一宏 岩井 一宏 IWAI Kazuhiro Structural basis of sugar-recognizing ubiquitin ligase. Structural basis of sugar-recognizing ubiquitin ligase. Structural basis of sugar-recognizing ubiquitin ligase. Nature Struct. Mol. Biol., 11, 365-370 Nature Struct. Mol. Biol., 11, 365-370 Nature Struct. Mol. Biol., 11, 365-370 2004/04 英語 研究論文(学術雑誌) 公開
岩井 一宏 岩井 一宏 IWAI Kazuhiro Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. Nature Cell Biology, 5, 336-340 Nature Cell Biology, 5, 336-340 Nature Cell Biology, 5, 336-340 2003/04 英語 研究論文(学術雑誌) 公開
K. Iwai K. Iwai Diverse roles of the ubiquitin system in NF-κB activation Diverse roles of the ubiquitin system in NF-κB activation Biochimica et Biophysica Acta - Molecular Cell Research, 1843, 1, 129-136 , 1843, 1, 129-136 Biochimica et Biophysica Acta - Molecular Cell Research, 1843, 1, 129-136 2014 英語 公開
T. Takiuchi; T. Nakagawa; H. Tamiya; H. Fujita; Y. Sasaki; Y. Saeki; H. Takeda; T. Sawasaki; A. Buchberger; T. Kimura; K. Iwai T. Takiuchi; T. Nakagawa; H. Tamiya; H. Fujita; Y. Sasaki; Y. Saeki; H. Takeda; T. Sawasaki; A. Buchberger; T. Kimura; K. Iwai Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN Genes to Cells, 19, 3, 254-272 , 19, 3, 254-272 Genes to Cells, 19, 3, 254-272 2014 英語 公開
K. Blackwell; L. Zhang; L.M. Workman; A.T. Ting; K. Iwai; H. Habelhah K. Blackwell; L. Zhang; L.M. Workman; A.T. Ting; K. Iwai; H. Habelhah Two coordinated mechanisms underlie tumor necrosis factor alpha-induced immediate and delayed IκB kinase activation Two coordinated mechanisms underlie tumor necrosis factor alpha-induced immediate and delayed IκB kinase activation Molecular and Cellular Biology, 33, 10, 1901-1915 , 33, 10, 1901-1915 Molecular and Cellular Biology, 33, 10, 1901-1915 2013 英語 公開
M. Seki; Y. Takeda; K. Iwai; K. Tanaka M. Seki; Y. Takeda; K. Iwai; K. Tanaka IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway Journal of Biological Chemistry, 288, 23, 16680-16689 , 288, 23, 16680-16689 Journal of Biological Chemistry, 288, 23, 16680-16689 2013 英語 公開
Y. Sasaki; S. Sano; M. Nakahara; S. Murata; K. Kometani; Y. Aiba; S. Sakamoto; Y. Watanabe; K. Tanaka; T. Kurosaki; K. Iwai Y. Sasaki; S. Sano; M. Nakahara; S. Murata; K. Kometani; Y. Aiba; S. Sakamoto; Y. Watanabe; K. Tanaka; T. Kurosaki; K. Iwai Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells EMBO Journal, 32, 18, 2463-2476 , 32, 18, 2463-2476 EMBO Journal, 32, 18, 2463-2476 2013 英語 公開
N. Fujita; E. Morita; T. Itoh; A. Tanaka; M. Nakaoka; Y. Osada; T. Umemoto; T. Saitoh; H. Nakatogawa; S. Kobayashi; T. Haraguchi; J.-L. Guan; K. Iwai; F. Tokunaga; K. Saito; K. Ishibashi; S. Akira; M. Fukuda; T. Noda; T. Yoshimori N. Fujita; E. Morita; T. Itoh; A. Tanaka; M. Nakaoka; Y. Osada; T. Umemoto; T. Saitoh; H. Nakatogawa; S. Kobayashi; T. Haraguchi; J.-L. Guan; K. Iwai; F. Tokunaga; K. Saito; K. Ishibashi; S. Akira; M. Fukuda; T. Noda; T. Yoshimori Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin Journal of Cell Biology, 203, 1, 115-128 , 203, 1, 115-128 Journal of Cell Biology, 203, 1, 115-128 2013 英語 公開
F. Tokunaga; H. Nishimasu; R. Ishitani; E. Goto; T. Noguchi; K. Mio; K. Kamei; A. Ma; K. Iwai; O. Nureki F. Tokunaga; H. Nishimasu; R. Ishitani; E. Goto; T. Noguchi; K. Mio; K. Kamei; A. Ma; K. Iwai; O. Nureki Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation EMBO Journal, 31, 19, 3856-3870 , 31, 19, 3856-3870 EMBO Journal, 31, 19, 3856-3870 2012/10/03 英語 公開
S.M. Belgnaoui; S. Paz; S. Samuel; M.-L. Goulet; Q. Sun; M. Kikkert; K. Iwai; I. Dikic; J. Hiscott; R. Lin S.M. Belgnaoui; S. Paz; S. Samuel; M.-L. Goulet; Q. Sun; M. Kikkert; K. Iwai; I. Dikic; J. Hiscott; R. Lin Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex Cell Host and Microbe, 12, 2, 211-222 , 12, 2, 211-222 Cell Host and Microbe, 12, 2, 211-222 2012/08/16 英語 公開
M. Tomonaga; N. Hashimoto; F. Tokunaga; M. Onishi; A. Myoui; H. Yoshikawa; K. Iwai M. Tomonaga; N. Hashimoto; F. Tokunaga; M. Onishi; A. Myoui; H. Yoshikawa; K. Iwai Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells International Journal of Oncology, 40, 2, 409-417 , 40, 2, 409-417 International Journal of Oncology, 40, 2, 409-417 2012/02 英語 公開
T. Kensche; F. Tokunaga; F. Ikeda; E. Goto; K. Iwai; I. Dikic T. Kensche; F. Tokunaga; F. Ikeda; E. Goto; K. Iwai; I. Dikic Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB Journal of Biological Chemistry, 287, 28, 23626-23634 , 287, 28, 23626-23634 Journal of Biological Chemistry, 287, 28, 23626-23634 2012 英語 公開
K. Iwai K. Iwai Diverse ubiquitin signaling in NF-κB activation Diverse ubiquitin signaling in NF-κB activation Trends in Cell Biology, 22, 7, 355-364 , 22, 7, 355-364 Trends in Cell Biology, 22, 7, 355-364 2012 英語 公開
H. Walczak; K. Iwai; I. Dikic H. Walczak; K. Iwai; I. Dikic Generation and physiological roles of linear ubiquitin chains Generation and physiological roles of linear ubiquitin chains BMC Biology, 10 , 10 BMC Biology, 10 2012 英語 公開
H. Yagi; K. Ishimoto; T. Hiromoto; H. Fujita; T. Mizushima; Y. Uekusa; M. Yagi-Utsumi; E. Kurimoto; M. Noda; S. Uchiyama; F. Tokunaga; K. Iwai; K. Kato H. Yagi; K. Ishimoto; T. Hiromoto; H. Fujita; T. Mizushima; Y. Uekusa; M. Yagi-Utsumi; E. Kurimoto; M. Noda; S. Uchiyama; F. Tokunaga; K. Iwai; K. Kato A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex EMBO Reports, 13, 5, 462-468 , 13, 5, 462-468 EMBO Reports, 13, 5, 462-468 2012 英語 公開
F. Tokunaga; K. Iwai F. Tokunaga; K. Iwai LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses Microbes and Infection, 14, 7-8, 563-572 , 14, 7-8, 563-572 Microbes and Infection, 14, 7-8, 563-572 2012 英語 公開
K. Iwai K. Iwai Synthesis and analysis of linear ubiquitin chains. Synthesis and analysis of linear ubiquitin chains. Methods in molecular biology (Clifton, N.J.), 832, 229-238 , 832, 229-238 Methods in molecular biology (Clifton, N.J.), 832, 229-238 2012 英語 公開
F. Tokunaga; K. Iwai F. Tokunaga; K. Iwai Linear ubiquitination: A novel NF-κB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex Linear ubiquitination: A novel NF-κB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex Endocrine Journal, 59, 8, 641-652 , 59, 8, 641-652 Endocrine Journal, 59, 8, 641-652 2012 英語 公開
R. Ueta; N. Fujiwara; K. Iwai; Y. Yamaguchi-iwai R. Ueta; N. Fujiwara; K. Iwai; Y. Yamaguchi-iwai Iron-induced dissociation of the aft1p transcriptional regulator from target gene promoters is an initial event in iron-dependent gene suppression Iron-induced dissociation of the aft1p transcriptional regulator from target gene promoters is an initial event in iron-dependent gene suppression Molecular and Cellular Biology, 32, 24, 4998-5008 , 32, 24, 4998-5008 Molecular and Cellular Biology, 32, 24, 4998-5008 2012 英語 公開
Y. Uekusa; S. Mimura; H. Sasakawa; E. Kurimoto; E. Sakata; S. Olivier; H. Yagi; F. Tokunaga; K. Iwai; K. Kato Y. Uekusa; S. Mimura; H. Sasakawa; E. Kurimoto; E. Sakata; S. Olivier; H. Yagi; F. Tokunaga; K. Iwai; K. Kato Backbone and side chain 1H, 13C, and 15N assignments of the ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex. Backbone and side chain 1H, 13C, and 15N assignments of the ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex. Biomolecular NMR assignments, 6, 2, 177-180 , 6, 2, 177-180 Biomolecular NMR assignments, 6, 2, 177-180 2012 英語 公開
Yagi, H., Ishimoto, K., Takeshi Hiromoto, T., Fujita, H., Mizushima, T., Uekusa, Y., Yagi-Utsumi, M., Kurimoto, E., Noda, M., Uchiyama, S., Tokunaga, F., Iwai, K. (Correspondence author) and Kato, K. Yagi, H., Ishimoto, K., Takeshi Hiromoto, T., Fujita, H., Mizushima, T., Uekusa, Y., Yagi-Utsumi, M., Kurimoto, E., Noda, M., Uchiyama, S., Tokunaga, F., Iwai, K. (Correspondence author) and Kato, K. Non-canonical UBA–UBL interaction mediates formation of linear ubiquitin chain assembly complex. Non-canonical UBA–UBL interaction mediates formation of linear ubiquitin chain assembly complex. EMBO Rep. 13:462-468 EMBO Rep. 13:462-468 2012 英語 公開
J. Niu; Y. Shi; K. Iwai; Z.-H. Wu J. Niu; Y. Shi; K. Iwai; Z.-H. Wu LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO EMBO Journal, 30, 18, 3741-3753 , 30, 18, 3741-3753 EMBO Journal, 30, 18, 3741-3753 2011/09/14 英語 公開
T. Moroishi; M. Nishiyama; Y. Takeda; K. Iwai; K.I. Nakayama T. Moroishi; M. Nishiyama; Y. Takeda; K. Iwai; K.I. Nakayama The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo Cell Metabolism, 14, 3, 339-351 , 14, 3, 339-351 Cell Metabolism, 14, 3, 339-351 2011/09/07 英語 公開
T. Asano; M. Komatsu; Y. Yamaguchi-Iwai; F. Ishikawa; N. Mizushima; K. Iwai T. Asano; M. Komatsu; Y. Yamaguchi-Iwai; F. Ishikawa; N. Mizushima; K. Iwai Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells Molecular and Cellular Biology, 31, 10, 2040-2052 , 31, 10, 2040-2052 Molecular and Cellular Biology, 31, 10, 2040-2052 2011/05 英語 公開
H. Ishikawa; M. Nakagaki; A. Bamba; T. Uchida; H. Hori; M.R. Oâbrian; K. Iwai; K. Ishimori H. Ishikawa; M. Nakagaki; A. Bamba; T. Uchida; H. Hori; M.R. Oâbrian; K. Iwai; K. Ishimori Unusual heme binding in the bacterial iron response regulator protein: Spectral characterization of heme binding to the heme regulatory motif Unusual heme binding in the bacterial iron response regulator protein: Spectral characterization of heme binding to the heme regulatory motif Biochemistry, 50, 6, 1016-1022 , 50, 6, 1016-1022 Biochemistry, 50, 6, 1016-1022 2011/02/15 英語 公開
F. Ikeda; Y.L. Deribe; S.S. Skånland; B. Stieglitz; C. Grabbe; M. Franz-Wachtel; S.J.L. Van Wijk; P. Goswami; V. Nagy; J. Terzic; F. Tokunaga; A. Androulidaki; T. Nakagawa; M. Pasparakis; K. Iwai; J.P. Sundberg; L. Schaefer; K. Rittinger; B. MacEk; I. Dikic F. Ikeda; Y.L. Deribe; S.S. Skånland; B. Stieglitz; C. Grabbe; M. Franz-Wachtel; S.J.L. Van Wijk; P. Goswami; V. Nagy; J. Terzic; F. Tokunaga; A. Androulidaki; T. Nakagawa; M. Pasparakis; K. Iwai; J.P. Sundberg; L. Schaefer; K. Rittinger; B. MacEk; I. Dikic SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis Nature, 471, 7340, 637-641 , 471, 7340, 637-641 Nature, 471, 7340, 637-641 2011 英語 公開
K. Shimada; M. Saeki; H. Egusa; S. Fukuyasu; Y. Yura; K. Iwai; Y. Kamisaki K. Shimada; M. Saeki; H. Egusa; S. Fukuyasu; Y. Yura; K. Iwai; Y. Kamisaki RPAP3 enhances cytotoxicity of doxorubicin by impairing NF-kappa B pathway RPAP3 enhances cytotoxicity of doxorubicin by impairing NF-kappa B pathway Biochemical and Biophysical Research Communications, 404, 4, 910-914 , 404, 4, 910-914 Biochemical and Biophysical Research Communications, 404, 4, 910-914 2011 英語 公開
K.-S. Inn; M.U. Gack; F. Tokunaga; M. Shi; L.-Y. Wong; K. Iwai; J.U. Jung K.-S. Inn; M.U. Gack; F. Tokunaga; M. Shi; L.-Y. Wong; K. Iwai; J.U. Jung Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction Molecular Cell, 41, 3, 354-365 , 41, 3, 354-365 Molecular Cell, 41, 3, 354-365 2011 英語 公開
F. Tokunaga; T. Nakagawa; M. Nakahara; Y. Saeki; M. Taniguchi; S.-I. Sakata; K. Tanaka; H. Nakano; K. Iwai F. Tokunaga; T. Nakagawa; M. Nakahara; Y. Saeki; M. Taniguchi; S.-I. Sakata; K. Tanaka; H. Nakano; K. Iwai SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex Nature, 471, 7340, 633-636 , 471, 7340, 633-636 Nature, 471, 7340, 633-636 2011 英語 公開
M. Takatsuka; M. Osada-Oka; E.F. Satoh; K. Kitadokoro; Y. Nishiuchi; M. Niki; M. Inoue; K. Iwai; T. Arakawa; Y. Shimoji; H. Ogura; K. Kobayashi; A. Rambukkana; S. Matsumoto M. Takatsuka; M. Osada-Oka; E.F. Satoh; K. Kitadokoro; Y. Nishiuchi; M. Niki; M. Inoue; K. Iwai; T. Arakawa; Y. Shimoji; H. Ogura; K. Kobayashi; A. Rambukkana; S. Matsumoto A histone-like protein of mycobacteria possesses ferritin superfamily protein-like activity and protects against DNA damage by Fenton reaction A histone-like protein of mycobacteria possesses ferritin superfamily protein-like activity and protects against DNA damage by Fenton reaction PLoS ONE, 6, 6 , 6, 6 PLoS ONE, 6, 6 2011 英語 公開
K. Iwai K. Iwai Linear polyubiquitin chains: A new modifier involved in NFκB activation and chronic inflammation including dermatitis Linear polyubiquitin chains: A new modifier involved in NFκB activation and chronic inflammation including dermatitis Cell Cycle, 10, 18, 3095-3104 , 10, 18, 3095-3104 Cell Cycle, 10, 18, 3095-3104 2011 英語 公開
Y. Uekusa; S. Mimura; H. Sasakawa; E. Kurimoto; E. Sakata; S. Olivier; H. Yagi; F. Tokunaga; K. Iwai; K. Kato Y. Uekusa; S. Mimura; H. Sasakawa; E. Kurimoto; E. Sakata; S. Olivier; H. Yagi; F. Tokunaga; K. Iwai; K. Kato Backbone and side chain <sup>1</sup>H, <sup>13</sup>C, and <sup>15</sup>N assignments of the ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex Backbone and side chain <sup>1</sup>H, <sup>13</sup>C, and <sup>15</sup>N assignments of the ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex Biomolecular NMR Assignments, 1-4 , 1-4 Biomolecular NMR Assignments, 1-4 2011 英語 公開
H. Morikawa; M. Kim; H. Mimuro; C. Punginelli; T. Koyama; S. Nagai; A. Miyawaki; K. Iwai; C. Sasakawa H. Morikawa; M. Kim; H. Mimuro; C. Punginelli; T. Koyama; S. Nagai; A. Miyawaki; K. Iwai; C. Sasakawa The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1 The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1 Biochemical and Biophysical Research Communications, 401, 2, 268-274 , 401, 2, 268-274 Biochemical and Biophysical Research Communications, 401, 2, 268-274 2010 英語 公開
K.-A. Ishii; T. Fumoto; K. Iwai; S. Takeshita; M. Ito; N. Shimohata; H. Aburatani; S. Taketani; C.J. Lelliott; A. Vidal-Puig; K. Ikeda K.-A. Ishii; T. Fumoto; K. Iwai; S. Takeshita; M. Ito; N. Shimohata; H. Aburatani; S. Taketani; C.J. Lelliott; A. Vidal-Puig; K. Ikeda Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation Nature Medicine, 15, 3, 259-266 , 15, 3, 259-266 Nature Medicine, 15, 3, 259-266 2009/03 英語 公開
F. Tokunaga; S.-I. Sakata; Y. Saeki; Y. Satomi; T. Kirisako; K. Kamei; T. Nakagawa; M. Kato; S. Murata; S. Yamaoka; M. Yamamoto; S. Akira; T. Takao; K. Tanaka; K. Iwai F. Tokunaga; S.-I. Sakata; Y. Saeki; Y. Satomi; T. Kirisako; K. Kamei; T. Nakagawa; M. Kato; S. Murata; S. Yamaoka; M. Yamamoto; S. Akira; T. Takao; K. Tanaka; K. Iwai Involvement of linear polyubiquitylation of NEMO in NF-κB activation Involvement of linear polyubiquitylation of NEMO in NF-κB activation Nature Cell Biology, 11, 2, 123-132 , 11, 2, 123-132 Nature Cell Biology, 11, 2, 123-132 2009 英語 公開
T. Izumi; A. Takaori-Kondo; K. Shirakawa; H. Higashitsuji; K. Itoh; K. Io; M. Matsui; K. Iwai; H. Kondoh; T. Sato; M. Tomonaga; S. Ikeda; H. Akari; Y. Koyanagi; J. Fujita; T. Uchiyama T. Izumi; A. Takaori-Kondo; K. Shirakawa; H. Higashitsuji; K. Itoh; K. Io; M. Matsui; K. Iwai; H. Kondoh; T. Sato; M. Tomonaga; S. Ikeda; H. Akari; Y. Koyanagi; J. Fujita; T. Uchiyama MDM2 is a novel E3 ligase for HIV-1 Vif MDM2 is a novel E3 ligase for HIV-1 Vif Retrovirology, 6 , 6 Retrovirology, 6 2009 英語 公開
T. Kumanomidou; T. Nakagawa; T. Mizushima; A. Suzuki; F. Tokunaga; K. Iwai; Y. Yoshida; K. Tanaka; T. Yamane T. Kumanomidou; T. Nakagawa; T. Mizushima; A. Suzuki; F. Tokunaga; K. Iwai; Y. Yoshida; K. Tanaka; T. Yamane Crystallization and preliminary X-ray characterization of the Skp1-Fbg3 complex Crystallization and preliminary X-ray characterization of the Skp1-Fbg3 complex Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66, 1, 95-98 , 66, 1, 95-98 Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66, 1, 95-98 2009 英語 公開
Y. Sato; A. Yoshikawa; A. Yamagata; H. Mimura; M. Yamashita; K. Ookata; O. Nureki; K. Iwai; M. Komada; S. Fukai Y. Sato; A. Yoshikawa; A. Yamagata; H. Mimura; M. Yamashita; K. Ookata; O. Nureki; K. Iwai; M. Komada; S. Fukai Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains Nature, 455, 7211, 358-362 , 455, 7211, 358-362 Nature, 455, 7211, 358-362 2008 英語 公開
H. Yano; I. Kobayashi; Y. Onodera; F. Luton; M. Franco; Y. Mazaki; S. Hashimoto; K. Iwai; Z. Ronai; H. Sabe H. Yano; I. Kobayashi; Y. Onodera; F. Luton; M. Franco; Y. Mazaki; S. Hashimoto; K. Iwai; Z. Ronai; H. Sabe Fbx8 makes Arf6 refractory to function via ubiquitination Fbx8 makes Arf6 refractory to function via ubiquitination Molecular Biology of the Cell, 19, 3, 822-832 , 19, 3, 822-832 Molecular Biology of the Cell, 19, 3, 822-832 2008 英語 公開
G. Zhou; L.A. Dada; N.S. Chandel; K. Iwai; E. Lecuona; A. Ciechanover; J.I. Sznajder G. Zhou; L.A. Dada; N.S. Chandel; K. Iwai; E. Lecuona; A. Ciechanover; J.I. Sznajder Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein FASEB Journal, 22, 5, 1335-1342 , 22, 5, 1335-1342 FASEB Journal, 22, 5, 1335-1342 2008 英語 公開
D. Morito; K. Hirao; Y. Oda; N. Hosokawa; F. Tokunaga; D.M. Cyr; K. Tanaka; K. Iwai; K. Nagata D. Morito; K. Hirao; Y. Oda; N. Hosokawa; F. Tokunaga; D.M. Cyr; K. Tanaka; K. Iwai; K. Nagata Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRΔF508 Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRΔF508 Molecular Biology of the Cell, 19, 4, 1328-1336 , 19, 4, 1328-1336 Molecular Biology of the Cell, 19, 4, 1328-1336 2008 英語 公開
Y. Miyauchi; M. Kato; F. Tokunaga; K. Iwai Y. Miyauchi; M. Kato; F. Tokunaga; K. Iwai The COP9/signalosome increases the efficiency of von hippel-lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-α ubiquitination The COP9/signalosome increases the efficiency of von hippel-lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-α ubiquitination Journal of Biological Chemistry, 283, 24, 16622-16631 , 283, 24, 16622-16631 Journal of Biological Chemistry, 283, 24, 16622-16631 2008 英語 公開
Y. Sato; A. Yoshikawa; A. Yamagata; H. Mimura; M. Yamashita; K. Ookata; O. Nureki; K. Iwai; M. Komada; S. Fukai Y. Sato; A. Yoshikawa; A. Yamagata; H. Mimura; M. Yamashita; K. Ookata; O. Nureki; K. Iwai; M. Komada; S. Fukai Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains (Nature (2008) 455, (358-362)) Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains (Nature (2008) 455, (358-362)) Nature, 456, 7219, 274- , 456, 7219, 274- Nature, 456, 7219, 274- 2008 英語 公開
R. Ueta; N. Fujiwara; K. Iwai; Y. Yamaguchi-Iwai R. Ueta; N. Fujiwara; K. Iwai; Y. Yamaguchi-Iwai Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae Molecular Biology of the Cell, 18, 8, 2980-2990 , 18, 8, 2980-2990 Molecular Biology of the Cell, 18, 8, 2980-2990 2007/08 英語 公開
E. Sakata; Y. Yamaguchi; Y. Miyauchi; K. Iwai; T. Chiba; Y. Saeki; N. Matsuda; K. Tanaka; K. Kato E. Sakata; Y. Yamaguchi; Y. Miyauchi; K. Iwai; T. Chiba; Y. Saeki; N. Matsuda; K. Tanaka; K. Kato Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity Nature Structural and Molecular Biology, 14, 2, 167-168 , 14, 2, 167-168 Nature Structural and Molecular Biology, 14, 2, 167-168 2007 英語 公開
Y. Yoshida; A. Murakami; K. Iwai; K. Tanaka Y. Yoshida; A. Murakami; K. Iwai; K. Tanaka A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation Journal of Biological Chemistry, 282, 10, 7137-7144 , 282, 10, 7137-7144 Journal of Biological Chemistry, 282, 10, 7137-7144 2007 英語 公開
Y. Zenke-Kawasaki; Y. Dohi; Y. Katoh; T. Ikura; M. Ikura; T. Asahara; F. Tokunaga; K. Iwai; K. Igarashi Y. Zenke-Kawasaki; Y. Dohi; Y. Katoh; T. Ikura; M. Ikura; T. Asahara; F. Tokunaga; K. Iwai; K. Igarashi Heme induces ubiquitination and degradation of the transcription factor Bach1 Heme induces ubiquitination and degradation of the transcription factor Bach1 Molecular and Cellular Biology, 27, 19, 6962-6971 , 27, 19, 6962-6971 Molecular and Cellular Biology, 27, 19, 6962-6971 2007 英語 公開
N. Shabek; K. Iwai; A. Ciechanover N. Shabek; K. Iwai; A. Ciechanover Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target Biochemical and Biophysical Research Communications, 363, 2, 425-431 , 363, 2, 425-431 Biochemical and Biophysical Research Communications, 363, 2, 425-431 2007 英語 公開
K. Nishitsuji; T. Tomiyama; K. Ishibashi; F. Kametani; K. Ozawa; R. Okada; M.L. Maat-Schieman; R.A.C. Roos; K. Iwai; H. Mori K. Nishitsuji; T. Tomiyama; K. Ishibashi; F. Kametani; K. Ozawa; R. Okada; M.L. Maat-Schieman; R.A.C. Roos; K. Iwai; H. Mori Cerebral vascular accumulation of Dutch-type Aβ42, but not wild-type Aβ42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type Cerebral vascular accumulation of Dutch-type Aβ42, but not wild-type Aβ42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type Journal of Neuroscience Research, 85, 13, 2917-2923 , 85, 13, 2917-2923 Journal of Neuroscience Research, 85, 13, 2917-2923 2007 英語 公開
T. Kirisako; K. Kamei; S. Murata; M. Kato; H. Fukumoto; M. Kanie; S. Sano; F. Tokunaga; K. Tanaka; K. Iwai T. Kirisako; K. Kamei; S. Murata; M. Kato; H. Fukumoto; M. Kanie; S. Sano; F. Tokunaga; K. Tanaka; K. Iwai A ubiquitin ligase complex assembles linear polyubiquitin chains A ubiquitin ligase complex assembles linear polyubiquitin chains EMBO Journal, 25, 20, 4877-4887 , 25, 20, 4877-4887 EMBO Journal, 25, 20, 4877-4887 2006/10/18 英語 公開
K. Shirakawa; A. Takaori-Kondo; M. Kobayashi; M. Tomonaga; T. Izumi; K. Fukunaga; A. Sasada; A. Abudu; Y. Miyauchi; H. Akari; K. Iwai; T. Uchiyama K. Shirakawa; A. Takaori-Kondo; M. Kobayashi; M. Tomonaga; T. Izumi; K. Fukunaga; A. Sasada; A. Abudu; Y. Miyauchi; H. Akari; K. Iwai; T. Uchiyama Ubiquitination of APOBEC3 proteins by the Vif-Cullin5-ElonginB-ElonginC complex Ubiquitination of APOBEC3 proteins by the Vif-Cullin5-ElonginB-ElonginC complex Virology, 344, 2, 263-266 , 344, 2, 263-266 Virology, 344, 2, 263-266 2006/01/20 英語 公開
J. Bayle; S. Lopez; K. Iwaï; P. Dubreuil; P. De Sepulveda J. Bayle; S. Lopez; K. Iwaï; P. Dubreuil; P. De Sepulveda The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins FEBS Letters, 580, 11, 2609-2614 , 580, 11, 2609-2614 FEBS Letters, 580, 11, 2609-2614 2006 英語 公開
M. Nakamura; F. Tokunaga; S.-i. Sakata; K. Iwai M. Nakamura; F. Tokunaga; S.-i. Sakata; K. Iwai Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex Biochemical and Biophysical Research Communications, 351, 2, 340-347 , 351, 2, 340-347 Biochemical and Biophysical Research Communications, 351, 2, 340-347 2006 英語 公開
O.N. Burchak; M. Jaquinod; C. Cottin; L. Mugherli; K. Iwai; F. Chatelain; M.Y. Balakirev O.N. Burchak; M. Jaquinod; C. Cottin; L. Mugherli; K. Iwai; F. Chatelain; M.Y. Balakirev Chemoenzymatic ubiquitination of artificial substrates Chemoenzymatic ubiquitination of artificial substrates ChemBioChem, 7, 11, 1667-1669 , 7, 11, 1667-1669 ChemBioChem, 7, 11, 1667-1669 2006 英語 公開
K.L. Lorick; Y. Yang; J.P. Jensen; K. Iwai; A.M. Weissman K.L. Lorick; Y. Yang; J.P. Jensen; K. Iwai; A.M. Weissman Studies of the ubiquitin proteasome system. Studies of the ubiquitin proteasome system. Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.], Chapter 15, Unit 15.9 , Chapter 15, Unit 15.9 Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.], Chapter 15, Unit 15.9 2006 英語 公開
M. Kobayashi; A. Takaori-Kondo; Y. Miyauchi; K. Iwai; T. Uchiyama M. Kobayashi; A. Takaori-Kondo; Y. Miyauchi; K. Iwai; T. Uchiyama Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif function Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif function Journal of Biological Chemistry, 280, 19, 18573-18578 , 280, 19, 18573-18578 Journal of Biological Chemistry, 280, 19, 18573-18578 2005/05/13 英語 公開
Y. Yoshida; E. Adachi; K. Fukiya; K. Iwai; K. Tanaka Y. Yoshida; E. Adachi; K. Fukiya; K. Iwai; K. Tanaka Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates EMBO Reports, 6, 3, 239-244 , 6, 3, 239-244 EMBO Reports, 6, 3, 239-244 2005 英語 公開
Y. Megumi; Y. Miyauchi; H. Sakurai; H. Nobeyama; K. Lorick; E. Nakamura; T. Chiba; K. Tanaka; A.M. Weissman; T. Kirisako; O. Ogawa; K. Iwai Y. Megumi; Y. Miyauchi; H. Sakurai; H. Nobeyama; K. Lorick; E. Nakamura; T. Chiba; K. Tanaka; A.M. Weissman; T. Kirisako; O. Ogawa; K. Iwai Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex Genes to Cells, 10, 7, 679-691 , 10, 7, 679-691 Genes to Cells, 10, 7, 679-691 2005 英語 公開
H. Ishikawa; M. Kato; H. Hori; K. Ishimori; T. Kirisako; F. Tokunaga; K. Iwai H. Ishikawa; M. Kato; H. Hori; K. Ishimori; T. Kirisako; F. Tokunaga; K. Iwai Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2 Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2 Molecular Cell, 19, 2, 171-181 , 19, 2, 171-181 Molecular Cell, 19, 2, 171-181 2005 英語 公開
K. Iwai; H. Ishikawa; T. Kirisako K. Iwai; H. Ishikawa; T. Kirisako Identification, expression, and assay of an oxidation-specific ubiquitin ligase, HOIL-1 Identification, expression, and assay of an oxidation-specific ubiquitin ligase, HOIL-1 Methods in Enzymology, 398, 256-271 , 398, 256-271 Methods in Enzymology, 398, 256-271 2005 英語 公開
E.G. Meyron-Holtz; M.C. Ghosh; K. Iwai; T. LaVaute; X. Brazzolotto; U.V. Berger; W. Land; H. Ollivierre-Wilson; A. Grinberg; P. Love; T.A. Rouault E.G. Meyron-Holtz; M.C. Ghosh; K. Iwai; T. LaVaute; X. Brazzolotto; U.V. Berger; W. Land; H. Ollivierre-Wilson; A. Grinberg; P. Love; T.A. Rouault Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis EMBO Journal, 23, 2, 386-395 , 23, 2, 386-395 EMBO Journal, 23, 2, 386-395 2004 英語 公開
A. Ciechanover; K. Iwai A. Ciechanover; K. Iwai The ubiquitin system: From basic mechanisms to the patient bed The ubiquitin system: From basic mechanisms to the patient bed IUBMB Life, 56, 4, 193-201 , 56, 4, 193-201 IUBMB Life, 56, 4, 193-201 2004 英語 公開
T. Tenno; K. Fujiwara; H. Tochio; K. Iwai; E.H. Morita; H. Hayashi; S. Murata; H. Hiroaki; M. Sato; K. Tanaka; M. Shirakawa T. Tenno; K. Fujiwara; H. Tochio; K. Iwai; E.H. Morita; H. Hayashi; S. Murata; H. Hiroaki; M. Sato; K. Tanaka; M. Shirakawa Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains Genes to Cells, 9, 10, 865-875 , 9, 10, 865-875 Genes to Cells, 9, 10, 865-875 2004 英語 公開
T. Tenno; K. Fujiwara; H. Tochio; K. Iwai; E.H. Morita; H. Hayashi; S. Murata; H. Hiroaki; M. Sato; K. Tanaka; M. Shirakawa T. Tenno; K. Fujiwara; H. Tochio; K. Iwai; E.H. Morita; H. Hayashi; S. Murata; H. Hiroaki; M. Sato; K. Tanaka; M. Shirakawa Erratum: Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains (Genes to Cells (2004) vol. 9 (865-875)) Erratum: Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains (Genes to Cells (2004) vol. 9 (865-875)) Genes to Cells, 9, 11, 1137- , 9, 11, 1137- Genes to Cells, 9, 11, 1137- 2004 英語 公開
H. Nobeyama; T. Sumi; F. Misugi; E. Okamoto; K. Hattori; Y. Matsumoto; T. Yasui; K. Honda; K. Iwai; O. Ishiko H. Nobeyama; T. Sumi; F. Misugi; E. Okamoto; K. Hattori; Y. Matsumoto; T. Yasui; K. Honda; K. Iwai; O. Ishiko Association of HPV infection with prognosis after neoadjuvant chemotherapy in advanced uterine cervical cancer. Association of HPV infection with prognosis after neoadjuvant chemotherapy in advanced uterine cervical cancer. International journal of molecular medicine, 14, 1, 101-105 , 14, 1, 101-105 International journal of molecular medicine, 14, 1, 101-105 2004 英語 公開
D. Ishida; K. Kometani; H. Yang; K. Kakugawa; K. Masuda; K. Iwai; M. Suzuki; S. Itohara; T. Nakahata; H. Hiai; H. Kawamoto; M. Hattori; N. Minato D. Ishida; K. Kometani; H. Yang; K. Kakugawa; K. Masuda; K. Iwai; M. Suzuki; S. Itohara; T. Nakahata; H. Hiai; H. Kawamoto; M. Hattori; N. Minato Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice Cancer Cell, 4, 1, 55-65 , 4, 1, 55-65 Cancer Cell, 4, 1, 55-65 2003/07 英語 公開
K. Iwai K. Iwai An ubiquitin ligase recognizing a protein oxidized by iron: Implications for the turnover of oxidatively damaged proteins An ubiquitin ligase recognizing a protein oxidized by iron: Implications for the turnover of oxidatively damaged proteins Journal of Biochemistry, 134, 2, 175-182 , 134, 2, 175-182 Journal of Biochemistry, 134, 2, 175-182 2003 英語 公開
Y. Yoshida; F. Tokunaga; T. Chiba; K. Iwai; K. Tanaka; T. Tai Y. Yoshida; F. Tokunaga; T. Chiba; K. Iwai; K. Tanaka; T. Tai Fbs2 Is a New Member of the E3 Ubiquitin Ligase Family That Recognizes Sugar Chains Fbs2 Is a New Member of the E3 Ubiquitin Ligase Family That Recognizes Sugar Chains Journal of Biological Chemistry, 278, 44, 43877-43884 , 278, 44, 43877-43884 Journal of Biological Chemistry, 278, 44, 43877-43884 2003 英語 公開
M. Ashizuka; T. Fukuda; T. Nakamura; K. Shirasuna; K. Iwai; H. Izumi; K. Kohno; M. Kuwano; T. Uchiumi M. Ashizuka; T. Fukuda; T. Nakamura; K. Shirasuna; K. Iwai; H. Izumi; K. Kohno; M. Kuwano; T. Uchiumi Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2 Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2 Molecular and Cellular Biology, 22, 18, 6375-6383 , 22, 18, 6375-6383 Molecular and Cellular Biology, 22, 18, 6375-6383 2002 英語 公開
A. Sasaki; Y. Masuda; K. Iwai; K. Ikeda; K. Watanabe A. Sasaki; Y. Masuda; K. Iwai; K. Ikeda; K. Watanabe A RING finger protein prajal regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/necdin family protein, Dlxin-1 A RING finger protein prajal regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/necdin family protein, Dlxin-1 Journal of Biological Chemistry, 277, 25, 22541-22546 , 277, 25, 22541-22546 Journal of Biological Chemistry, 277, 25, 22541-22546 2002 英語 公開
R.E. Amir; K. Iwai; A. Ciechanover R.E. Amir; K. Iwai; A. Ciechanover The NEDD8 pathway is essential for SCf<sup>β-TrCP</sup>-mediated ubiquitination and processing of the NF-κB precursor p105 The NEDD8 pathway is essential for SCf<sup>β-TrCP</sup>-mediated ubiquitination and processing of the NF-κB precursor p105 Journal of Biological Chemistry, 277, 26, 23253-23259 , 277, 26, 23253-23259 Journal of Biological Chemistry, 277, 26, 23253-23259 2002 英語 公開
A. Ciechanover; H. Gonen; B. Bercovich; S. Cohen; I. Fajerman; A. Israël; F. Mercurio; C. Kahana; A.L. Schwartz; K. Iwai; A. Orian A. Ciechanover; H. Gonen; B. Bercovich; S. Cohen; I. Fajerman; A. Israël; F. Mercurio; C. Kahana; A.L. Schwartz; K. Iwai; A. Orian Mechanisms of ubiquitin-mediated, limited processing of the NF-κB1 precursor protein p105 Mechanisms of ubiquitin-mediated, limited processing of the NF-κB1 precursor protein p105 Biochimie, 83, 3-4, 341-349 , 83, 3-4, 341-349 Biochimie, 83, 3-4, 341-349 2001 英語 公開
T. LaVaute; S. Smith; S. Cooperman; K. Iwai; W. Land; E. Meyron-Holtz; S.K. Drake; G. Miller; M. Abu-Asab; M. Tsokos; R. Switzer III; A. Grinberg; P. Love; N. Tresser; T.A. Rouault T. LaVaute; S. Smith; S. Cooperman; K. Iwai; W. Land; E. Meyron-Holtz; S.K. Drake; G. Miller; M. Abu-Asab; M. Tsokos; R. Switzer III; A. Grinberg; P. Love; N. Tresser; T.A. Rouault Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice Nature Genetics, 27, 2, 209-214 , 27, 2, 209-214 Nature Genetics, 27, 2, 209-214 2001 英語 公開
H. Okuda; K. Saitoh; S.-I. Hirai; K. Iwai; Y. Takaki; M. Baba; N. Minato; S. Ohno; T. Shuin H. Okuda; K. Saitoh; S.-I. Hirai; K. Iwai; Y. Takaki; M. Baba; N. Minato; S. Ohno; T. Shuin The von Hippel-Lindau Tumor Suppressor Protein Mediates Ubiquitination of Activated Atypical Protein Kinase C The von Hippel-Lindau Tumor Suppressor Protein Mediates Ubiquitination of Activated Atypical Protein Kinase C Journal of Biological Chemistry, 276, 47, 43611-43617 , 276, 47, 43611-43617 Journal of Biological Chemistry, 276, 47, 43611-43617 2001 英語 公開
T. Kawakami; T. Chiba; T. Suzuki; K. Iwai; K. Yamanaka; N. Minato; H. Suzuki; N. Shimbara; Y. Hidaka; F. Osaka; M. Omata; K. Tanaka T. Kawakami; T. Chiba; T. Suzuki; K. Iwai; K. Yamanaka; N. Minato; H. Suzuki; N. Shimbara; Y. Hidaka; F. Osaka; M. Omata; K. Tanaka NEDD8 recruits E2-ubiquitin to SCF E3 ligase NEDD8 recruits E2-ubiquitin to SCF E3 ligase EMBO Journal, 20, 15, 4003-4012 , 20, 15, 4003-4012 EMBO Journal, 20, 15, 4003-4012 2001 英語 公開
H. Shimura; N. Hattori; S.-I. Kubo; Y. Mizuno; S. Asakawa; S. Minoshima; N. Shimizu; K. Iwai; T. Chiba; K. Tanaka; T. Suzuki H. Shimura; N. Hattori; S.-I. Kubo; Y. Mizuno; S. Asakawa; S. Minoshima; N. Shimizu; K. Iwai; T. Chiba; K. Tanaka; T. Suzuki Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase Nature Genetics, 25, 3, 302-305 , 25, 3, 302-305 Nature Genetics, 25, 3, 302-305 2000 英語 公開
A. Orian; H. Gonen; B. Bercovich; I. Fajerman; E. Eytan; A. Israël; F. Mercurio; K. Iwai; A.L. Schwartz; A. Ciechanover A. Orian; H. Gonen; B. Bercovich; I. Fajerman; E. Eytan; A. Israël; F. Mercurio; K. Iwai; A.L. Schwartz; A. Ciechanover SCF(β-TrCP) ubiquitin ligase-mediated processing of NF-κB p105 requires phosphorylation of its C-terminus by IκB kinase SCF(β-TrCP) ubiquitin ligase-mediated processing of NF-κB p105 requires phosphorylation of its C-terminus by IκB kinase EMBO Journal, 19, 11, 2580-2591 , 19, 11, 2580-2591 EMBO Journal, 19, 11, 2580-2591 2000 英語 公開
E. Sadot; I. Simcha; K. Iwai; A. Ciechanover; B. Geiger; A. Ben-Ze'ev E. Sadot; I. Simcha; K. Iwai; A. Ciechanover; B. Geiger; A. Ben-Ze'ev Differential interaction of plakoglobin and β-catenin with the ubiquitin-proteasome system Differential interaction of plakoglobin and β-catenin with the ubiquitin-proteasome system Oncogene, 19, 16, 1992-2001 , 19, 16, 1992-2001 Oncogene, 19, 16, 1992-2001 2000 英語 公開
E. Nakamura; M. Sato; H. Yang; F. Miyagawa; M. Harasaki; K. Tomita; S. Matsuoka; A. Noma; K. Iwai; N. Minato E. Nakamura; M. Sato; H. Yang; F. Miyagawa; M. Harasaki; K. Tomita; S. Matsuoka; A. Noma; K. Iwai; N. Minato 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer Journal of Biological Chemistry, 274, 5, 3009-3016 , 274, 5, 3009-3016 Journal of Biological Chemistry, 274, 5, 3009-3016 1999/01/29 英語 公開
G. Levkowitz; H. Waterman; S.A. Ettenberg; M. Katz; A.Y. Tsygankov; I. Alroy; S. Lavi; K. Iwai; Y. Reiss; A. Ciechanover; S. Lipkowitz; Y. Yarden G. Levkowitz; H. Waterman; S.A. Ettenberg; M. Katz; A.Y. Tsygankov; I. Alroy; S. Lavi; K. Iwai; Y. Reiss; A. Ciechanover; S. Lipkowitz; Y. Yarden Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1 Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1 Molecular Cell, 4, 6, 1029-1040 , 4, 6, 1029-1040 Molecular Cell, 4, 6, 1029-1040 1999 英語 公開
H. Gonen; B. Bercovich; A. Orian; A. Carrano; C. Takizawa; K. Yamanaka; M. Pagano; K. Iwai; A. Ciechanover H. Gonen; B. Bercovich; A. Orian; A. Carrano; C. Takizawa; K. Yamanaka; M. Pagano; K. Iwai; A. Ciechanover Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IκBα Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IκBα Journal of Biological Chemistry, 274, 21, 14823-14830 , 274, 21, 14823-14830 Journal of Biological Chemistry, 274, 21, 14823-14830 1999 英語 公開
K. Yamanaka; N. Minato; K. Iwai K. Yamanaka; N. Minato; K. Iwai Stabilization of iron regulatory protein 2, IRP2, by aluminum Stabilization of iron regulatory protein 2, IRP2, by aluminum FEBS Letters, 462, 1-2, 216-220 , 462, 1-2, 216-220 FEBS Letters, 462, 1-2, 216-220 1999 英語 公開
H. Kurachi; Y. Wada; N. Tsukamoto; M. Maeda; H. Kubota; M. Hattori; K. Iwai; N. Minato H. Kurachi; Y. Wada; N. Tsukamoto; M. Maeda; H. Kubota; M. Hattori; K. Iwai; N. Minato Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product Journal of Biological Chemistry, 272, 44, 28081-28088 , 272, 44, 28081-28088 Journal of Biological Chemistry, 272, 44, 28081-28088 1997 英語 公開
Y. Wada; H. Kubota; M. Maeda; M. Taniwaki; M. Hattori; S. Imamura; K. Iwai; N. Minato Y. Wada; H. Kubota; M. Maeda; M. Taniwaki; M. Hattori; S. Imamura; K. Iwai; N. Minato Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 Centromeric to BCL1 in human Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 Centromeric to BCL1 in human Genomics, 39, 1, 66-73 , 39, 1, 66-73 Genomics, 39, 1, 66-73 1997 英語 公開
H.-Y. Kim; T. LaVaute; K. Iwai; R.D. Klausner; T.A. Rouault H.-Y. Kim; T. LaVaute; K. Iwai; R.D. Klausner; T.A. Rouault Identification of a conserved and functional iron-responsive element in the 5\\'-untranslated region of mammalian mitochondrial aconitase Identification of a conserved and functional iron-responsive element in the 5\\'-untranslated region of mammalian mitochondrial aconitase Journal of Biological Chemistry, 271, 39, 24226-24230 , 271, 39, 24226-24230 Journal of Biological Chemistry, 271, 39, 24226-24230 1996 英語 公開
P.A. DeRusso; C.C. Philpott; K. Iwai; H.S. Mostowski; R.D. Klausner; T.A. Rouault P.A. DeRusso; C.C. Philpott; K. Iwai; H.S. Mostowski; R.D. Klausner; T.A. Rouault Expression of a constitutive mutant of iron regulatory protein 1 abolishes iron homeostasis in mammalian cells Expression of a constitutive mutant of iron regulatory protein 1 abolishes iron homeostasis in mammalian cells Journal of Biological Chemistry, 270, 26, 15451-15454 , 270, 26, 15451-15454 Journal of Biological Chemistry, 270, 26, 15451-15454 1995 英語 公開
K. Iwai; R.D. Klausner; T.A. Rouault K. Iwai; R.D. Klausner; T.A. Rouault Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein EMBO Journal, 14, 21, 5350-5357 , 14, 21, 5350-5357 EMBO Journal, 14, 21, 5350-5357 1995 英語 公開
M. Hattori; N. Tsukamoto; M.S.A. Nur-E-Kamal; B. Rubinfeld; K. Iwai; H. Kubota; H. Maruta; N. Minato M. Hattori; N. Tsukamoto; M.S.A. Nur-E-Kamal; B. Rubinfeld; K. Iwai; H. Kubota; H. Maruta; N. Minato Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression Molecular and Cellular Biology, 15, 1, 552-560 , 15, 1, 552-560 Molecular and Cellular Biology, 15, 1, 552-560 1995 英語 公開
H. Kubota; M. Sato; Y. Ogawa; K. Iwai; M. Hattori; T. Yoshida; N. Minato H. Kubota; M. Sato; Y. Ogawa; K. Iwai; M. Hattori; T. Yoshida; N. Minato Involvement of 4F2 antigen expressed on the MHC-negative target cells in the recognition of murine CD3<sup>+</sup>CD4<sup>-</sup>CD8<sup>-</sup> αβ (V(α)4/V(β)2) T cells Involvement of 4F2 antigen expressed on the MHC-negative target cells in the recognition of murine CD3<sup>+</sup>CD4<sup>-</sup>CD8<sup>-</sup> αβ (V(α)4/V(β)2) T cells International Immunology, 6, 9, 1323-1331 , 6, 9, 1323-1331 International Immunology, 6, 9, 1323-1331 1994 英語 公開
F. Samaniego; J. Chin; K. Iwai; T.A. Rouault; R.D. Klausner F. Samaniego; J. Chin; K. Iwai; T.A. Rouault; R.D. Klausner Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2: Structure, function, and post-translational regulation Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2: Structure, function, and post-translational regulation Journal of Biological Chemistry, 269, 49, 30904-30910 , 269, 49, 30904-30910 Journal of Biological Chemistry, 269, 49, 30904-30910 1994 英語 公開
M. Tomana; S. Ideyama; K. Iwai; J.-I. Gyotoku; W.T.V. Germeraad; S. Muramatsu; Y. Katsura M. Tomana; S. Ideyama; K. Iwai; J.-I. Gyotoku; W.T.V. Germeraad; S. Muramatsu; Y. Katsura Involvement of IL-7 in the development of γδ T cells in the thymus Involvement of IL-7 in the development of γδ T cells in the thymus Thymus, 21, 3, 141-157 , 21, 3, 141-157 Thymus, 21, 3, 141-157 1993 英語 公開
Y. Watanabe; O. Mazda; Y.-I. Aiba; K. Iwai; J.-I. Gyotoku; S. Ideyama; J. Miyazaki; Y. Katsura Y. Watanabe; O. Mazda; Y.-I. Aiba; K. Iwai; J.-I. Gyotoku; S. Ideyama; J. Miyazaki; Y. Katsura A murine thymic stromal cell line which may support the differentiation of CD4<sup>-</sup>8<sup>-</sup> thymocytes into CD4<sup>+</sup>8<sup>-</sup> αβ T cell receptor positive T cells A murine thymic stromal cell line which may support the differentiation of CD4<sup>-</sup>8<sup>-</sup> thymocytes into CD4<sup>+</sup>8<sup>-</sup> αβ T cell receptor positive T cells Cellular Immunology, 142, 2, 385-397 , 142, 2, 385-397 Cellular Immunology, 142, 2, 385-397 1992 英語 公開
K. Iwai; T. Tsubata; Y. Katsura; S. Kumagai; H. Imura K. Iwai; T. Tsubata; Y. Katsura; S. Kumagai; H. Imura Qualitative difference of anti-DNA antibody-producing cell precursors in the pre-immune B cell repertoire between normal and lupus-prone mice Qualitative difference of anti-DNA antibody-producing cell precursors in the pre-immune B cell repertoire between normal and lupus-prone mice Clinical and Experimental Immunology, 86, 1, 106-111 , 86, 1, 106-111 Clinical and Experimental Immunology, 86, 1, 106-111 1991 英語 公開

  • <<
  • >>
  • 表示
タイトル言語:
講演・口頭発表等
タイトル タイトル(日本語) タイトル(英語) 会議名 会議名(日本語) 会議名(英語) 主催者 主催者(日本語) 主催者(英語) 開催年月日 記述言語 会議種別 公開
Mechanisms underlying the formation and destabilization of the LUBAC ligase complex.[招待あり] Mechanisms underlying the formation and destabilization of the LUBAC ligase complex. [招待あり] Mechanisms underlying the formation and destabilization of the LUBAC ligase complex. [招待あり] Cold Spring Harbor Asia Conference “Ubiquitin Family, Autophagy & Diseases” Cold Spring Harbor Asia Conference “Ubiquitin Family, Autophagy & Diseases” Cold Spring Harbor Asia Conference “Ubiquitin Family, Autophagy & Diseases” 2018/04 英語 口頭発表(招待・特別) 公開
Linear ubiquitin chains: NF-kappaB activation, cell death, and oncogenesis[招待あり] Linear ubiquitin chains: NF-kappaB activation, cell death, and oncogenesis [招待あり] Linear ubiquitin chains: NF-kappaB activation, cell death, and oncogenesis [招待あり] 2017 International protein metabolism and disease conference 2017 International protein metabolism and disease conference 2017 International protein metabolism and disease conference 2017/07 英語 口頭発表(招待・特別) 公開
Differential involvement of subunits of LUBAC ubiquitin ligase in signalling and cell death. Differential involvement of subunits of LUBAC ubiquitin ligase in signalling and cell death. Differential involvement of subunits of LUBAC ubiquitin ligase in signalling and cell death. EMBO Conference “Ubiquitin and ubiquitin-like modifiers: From molecular mechanisms to human diseases EMBO Conference “Ubiquitin and ubiquitin-like modifiers: From molecular mechanisms to human diseases EMBO Conference “Ubiquitin and ubiquitin-like modifiers: From molecular mechanisms to human diseases 2015/09 英語 口頭発表(一般) 公開
Linear ubiquitin chains: a new regulator of NF-kappaB activation and cell death signaling.[招待あり] Linear ubiquitin chains: a new regulator of NF-kappaB activation and cell death signaling. [招待あり] Linear ubiquitin chains: a new regulator of NF-kappaB activation and cell death signaling. [招待あり] 1st SPS International Symposium Xiamen University 1st SPS International Symposium Xiamen University 1st SPS International Symposium Xiamen University 2015/06 英語 口頭発表(招待・特別) 公開
Linear ubiquitin chains: NF-kappaB activation, cell death, and cancer.[招待あり] Linear ubiquitin chains: NF-kappaB activation, cell death, and cancer. [招待あり] Linear ubiquitin chains: NF-kappaB activation, cell death, and cancer. [招待あり] International Symposium on Ubiquitin and Diseases. International Symposium on Ubiquitin and Diseases. International Symposium on Ubiquitin and Diseases. 2015/06 英語 口頭発表(招待・特別) 公開
Inhibition of LUBAC-mediated linear ubiquitination by a virulence factor of Aspergillus, gliotoxin Inhibition of LUBAC-mediated linear ubiquitination by a virulence factor of Aspergillus, gliotoxin Inhibition of LUBAC-mediated linear ubiquitination by a virulence factor of Aspergillus, gliotoxin Cold Spring Harbor Laboratory meeting “The Ubiquitin Family” Cold Spring Harbor Laboratory meeting “The Ubiquitin Family” Cold Spring Harbor Laboratory meeting “The Ubiquitin Family” 2015/04 英語 口頭発表(一般) 公開
Phenotypical difference between mice lacking subunits of LUBAC ubiquitin ligase.[招待あり] Phenotypical difference between mice lacking subunits of LUBAC ubiquitin ligase. [招待あり] Phenotypical difference between mice lacking subunits of LUBAC ubiquitin ligase. [招待あり] 1st International Symposium for New Aspects of the Ubiquitin Research 1st International Symposium for New Aspects of the Ubiquitin Research 1st International Symposium for New Aspects of the Ubiquitin Research 2014/11 英語 口頭発表(招待・特別) 公開
Induction of expression of linear ubiquitin chain generating LUBAC ligase and amelioration of dermatitis in cpdm mice by interferons. Induction of expression of linear ubiquitin chain generating LUBAC ligase and amelioration of dermatitis in cpdm mice by interferons. Induction of expression of linear ubiquitin chain generating LUBAC ligase and amelioration of dermatitis in cpdm mice by interferons. The EMBO conference “Ubiquitin & ubiquitin-like proteins: At the crossroads from chromatin to protein” The EMBO conference “Ubiquitin & ubiquitin-like proteins: At the crossroads from chromatin to protein” The EMBO conference “Ubiquitin & ubiquitin-like proteins: At the crossroads from chromatin to protein” 2014/10 英語 口頭発表(一般) 公開
Linear ubiquitination : a new regulator of NF-kappaB and cell death signaling.[招待あり] Linear ubiquitination : a new regulator of NF-kappaB and cell death signaling. [招待あり] Linear ubiquitination : a new regulator of NF-kappaB and cell death signaling. [招待あり] 2014 International Conference on Protein Metabolism & Diseases 2014 International Conference on Protein Metabolism & Diseases 2014 International Conference on Protein Metabolism & Diseases 2014/07 英語 口頭発表(招待・特別) 公開
Linear Polyubiquitination: a Crucial Regulator of NF-kappaB Activation.[招待あり] Linear Polyubiquitination: a Crucial Regulator of NF-kappaB Activation. [招待あり] Linear Polyubiquitination: a Crucial Regulator of NF-kappaB Activation. [招待あり] THE UEHARA MEMORIAL FOUNDATION SYMPOSIUM 2014, Innovative Medicine : Basic Research and Development THE UEHARA MEMORIAL FOUNDATION SYMPOSIUM 2014, Innovative Medicine : Basic Research and Development THE UEHARA MEMORIAL FOUNDATION SYMPOSIUM 2014, Innovative Medicine : Basic Research and Development 2014/06 英語 口頭発表(招待・特別) 公開
Molecular mechanism and regulation of linear chain-mediated NF-B activation.[招待あり] Molecular mechanism and regulation of linear chain-mediated NF-B activation. [招待あり] Molecular mechanism and regulation of linear chain-mediated NF-B activation. [招待あり] Cold Spring Harbor Asia Conference “ Protein Modifications & Homeostasis” Cold Spring Harbor Asia Conference “ Protein Modifications & Homeostasis” Cold Spring Harbor Asia Conference “ Protein Modifications & Homeostasis” 2014/06 英語 口頭発表(招待・特別) 公開
Increased redox-active iron induces mitochondrial damage that recruits Parkin.[招待あり] Increased redox-active iron induces mitochondrial damage that recruits Parkin. [招待あり] Increased redox-active iron induces mitochondrial damage that recruits Parkin. [招待あり] The 17th Biennial Meeting of Society for Free Radical Research International. Symposium “Redox-Active Iron in Disease Pathology and Treatment” The 17th Biennial Meeting of Society for Free Radical Research International. Symposium “Redox-Active Iron in Disease Pathology and Treatment” The 17th Biennial Meeting of Society for Free Radical Research International. Symposium “Redox-Active Iron in Disease Pathology and Treatment” 2014/03 英語 口頭発表(招待・特別) 公開
Differential requirement of LUBAC-mediated linear polyubiquitination in CD40- or BCR-mediated canonical NF-kappaB activation in B cells. Differential requirement of LUBAC-mediated linear polyubiquitination in CD40- or BCR-mediated canonical NF-kappaB activation in B cells. Differential requirement of LUBAC-mediated linear polyubiquitination in CD40- or BCR-mediated canonical NF-kappaB activation in B cells. The EMBO Conference “Ubiquitin and Ubiquitin-like Proteins: From structure to function” The EMBO Conference “Ubiquitin and Ubiquitin-like Proteins: From structure to function” The EMBO Conference “Ubiquitin and Ubiquitin-like Proteins: From structure to function” 2013/10 英語 口頭発表(一般) 公開
Linear polyubiquitination: a new regulator of NF-kappaB activation.[招待あり] Linear polyubiquitination: a new regulator of NF-kappaB activation. [招待あり] Linear polyubiquitination: a new regulator of NF-kappaB activation. [招待あり] The 38th FEBS congress symposium “Regulation of biological processes by ubiquitin and ubiquitin-like proteins in health and disease: proteolysis, autophagy and apoptosis” The 38th FEBS congress symposium “Regulation of biological processes by ubiquitin and ubiquitin-like proteins in health and disease: proteolysis, autophagy and apoptosis” The 38th FEBS congress symposium “Regulation of biological processes by ubiquitin and ubiquitin-like proteins in health and disease: proteolysis, autophagy and apoptosis” 2013/07 英語 口頭発表(招待・特別) 公開
Linear polyubiquitination : A crucial regulator of NF-kappaB signaling.[招待あり] Linear polyubiquitination : A crucial regulator of NF-kappaB signaling. [招待あり] Linear polyubiquitination : A crucial regulator of NF-kappaB signaling. [招待あり] The 3rd International Symposium "Signaling and Regulation in the Immune and Nervous Systems“ The 3rd International Symposium "Signaling and Regulation in the Immune and Nervous Systems“ The 3rd International Symposium "Signaling and Regulation in the Immune and Nervous Systems“ 2012/11 英語 口頭発表(招待・特別) 公開
Linear polyubiquitination: A crucial regulator of NF-kappaB signalling[招待あり] Linear polyubiquitination: A crucial regulator of NF-kappaB signalling [招待あり] Linear polyubiquitination: A crucial regulator of NF-kappaB signalling [招待あり] ZOMESVII conference ZOMESVII conference ZOMESVII conference 2012/09 英語 口頭発表(招待・特別) 公開
Mechanism underlying generation of linear polyubiquitin chains.[招待あり] Mechanism underlying generation of linear polyubiquitin chains. [招待あり] Mechanism underlying generation of linear polyubiquitin chains. [招待あり] 4th Annual Ubiquitin Drug Discovery & Diagnostics Conference 2012 4th Annual Ubiquitin Drug Discovery & Diagnostics Conference 2012 4th Annual Ubiquitin Drug Discovery & Diagnostics Conference 2012 2012/07 英語 口頭発表(招待・特別) 公開
Linear polyubiquitination: a regulator of NF-kappaB activation.[招待あり] Linear polyubiquitination: a regulator of NF-kappaB activation. [招待あり] Linear polyubiquitination: a regulator of NF-kappaB activation. [招待あり] FASEB Summer Research Conferences “Ubiquitin & Cellular Regulation” FASEB Summer Research Conferences “Ubiquitin & Cellular Regulation” FASEB Summer Research Conferences “Ubiquitin & Cellular Regulation” 2012/06 英語 口頭発表(招待・特別) 公開
Linear polyubiquitination : A crucial regulator of NF-kappaB signaling.[招待あり] Linear polyubiquitination : A crucial regulator of NF-kappaB signaling. [招待あり] Linear polyubiquitination : A crucial regulator of NF-kappaB signaling. [招待あり] Keystone Symposium “NF-kappaB signaling and Biology: From Bench to Bedside” and “Ubiquitin Signaling” Keystone Symposium “NF-kappaB signaling and Biology: From Bench to Bedside” and “Ubiquitin Signaling” Keystone Symposium “NF-B signaling and Biology: From Bench to Bedside” and “Ubiquitin Signaling” 2012/03 英語 口頭発表(招待・特別) 公開
Linear polyubiquitination : A new regulator of NF-kappaB activation.[招待あり] Linear polyubiquitination : A new regulator of NF-kappaB activation. [招待あり] Linear polyubiquitination : A new regulator of NF-kappaB activation. [招待あり] The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers: From functional modules to system biology The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers: From functional modules to system biology The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers: From functional modules to system biology 2011/09 英語 口頭発表(招待・特別) 公開
Linear polyubiquitination: a new regulator of NF-kappaB signaling.[招待あり] Linear polyubiquitination: a new regulator of NF-kappaB signaling. [招待あり] Linear polyubiquitination: a new regulator of NF-kappaB signaling. [招待あり] Banbury Center meetings, “SIGNALING THROUGH UBIQUITIN” Banbury Center meetings, “SIGNALING THROUGH UBIQUITIN” Banbury Center meetings, “SIGNALING THROUGH UBIQUITIN” 2010/11 英語 口頭発表(招待・特別) 公開
Dissection of intracellular heme transport mechanism using a baker’s yeast, Saccharomyces cerevisiae.[招待あり] Dissection of intracellular heme transport mechanism using a baker’s yeast, Saccharomyces cerevisiae. [招待あり] Dissection of intracellular heme transport mechanism using a baker’s yeast, Saccharomyces cerevisiae. [招待あり] JSH International Symposium 2010 in Akita, Seven Wonders of Erythropoiesis JSH International Symposium 2010 in Akita, Seven Wonders of Erythropoiesis JSH International Symposium 2010 in Akita, Seven Wonders of Erythropoiesis 2010/07 英語 口頭発表(招待・特別) 公開
Linear polyubiquitination: a new regulator of NF-kappaB signaling.[招待あり] Linear polyubiquitination: a new regulator of NF-kappaB signaling. [招待あり] Linear polyubiquitination: a new regulator of NF-kappaB signaling. [招待あり] FASEB Summer Research Conferences “Ubiquitin and Cellular Regulation” FASEB Summer Research Conferences “Ubiquitin and Cellular Regulation” FASEB Summer Research Conferences “Ubiquitin and Cellular Regulation” 2010/06 英語 口頭発表(招待・特別) 公開
Linear Polyubiquitination: A Newly Identified Regulator of NF-kB Signaling.[招待あり] Linear Polyubiquitination: A Newly Identified Regulator of NF-kB Signaling. [招待あり] Linear Polyubiquitination: A Newly Identified Regulator of NF-kB Signaling. [招待あり] “BIOLOGY OF THE UBIQUITIN AND THE UBIQUITIN-LIKE SYSTEMS” Research Conference of the Institute for Advanced Studies, the Israel Science Foundation. “BIOLOGY OF THE UBIQUITIN AND THE UBIQUITIN-LIKE SYSTEMS” Research Conference of the Institute for Advanced Studies, the Israel Science Foundation. “BIOLOGY OF THE UBIQUITIN AND THE UBIQUITIN-LIKE SYSTEMS” Research Conference of the Institute for Advanced Studies, the Israel Science Foundation. 2010/03 英語 口頭発表(招待・特別) 公開
Linear polyubiquitination : A newly identified regulator of NF-kappaB signaling. Linear polyubiquitination : A newly identified regulator of NF-kappaB signaling. Linear polyubiquitination : A newly identified regulator of NF-kappaB signaling. Keystone Symposium “NF-kappaB in Inflammation and Disease” Keystone Symposium “NF-kappaB in Inflammation and Disease” Keystone Symposium “NF-kappaB in Inflammation and Disease” 2010/01 英語 口頭発表(一般) 公開
Linear polyubiquitination : A newly identified regulator of NF-kappaB signaling.[招待あり] Linear polyubiquitination : A newly identified regulator of NF-kappaB signaling. [招待あり] Linear polyubiquitination : A newly identified regulator of NF-kappaB signaling. [招待あり] The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation” The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation” The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation” 2009/09 英語 口頭発表(招待・特別) 公開
Involvement of linear polyubiquitination of NEMO in NF-kappaB activation. Involvement of linear polyubiquitination of NEMO in NF-kappaB activation. Involvement of linear polyubiquitination of NEMO in NF-kappaB activation. Cold Spring Harbor Laboratory meeting “The Ubiquitin Family” Cold Spring Harbor Laboratory meeting “The Ubiquitin Family” Cold Spring Harbor Laboratory meeting “The Ubiquitin Family” 2009/04 英語 口頭発表(一般) 公開
Physiological Function of Linear Polyubiquitin Chain.[招待あり] Physiological Function of Linear Polyubiquitin Chain. [招待あり] Physiological Function of Linear Polyubiquitin Chain. [招待あり] Keystone Symposium “The Many Faces of Ubiquitin” Keystone Symposium “The Many Faces of Ubiquitin” Keystone Symposium “The Many Faces of Ubiquitin” 2009/01 英語 口頭発表(招待・特別) 公開
Prevention of TNF-alpha induced apoptosis by linear polyubiquitination.[招待あり] Prevention of TNF-alpha induced apoptosis by linear polyubiquitination. [招待あり] Prevention of TNF-alpha induced apoptosis by linear polyubiquitination. [招待あり] Takeda Science Foundation Symposium on Bioscience “Cell Death: What have we learned and what will we learn?” Takeda Science Foundation Symposium on Bioscience “Cell Death: What have we learned and what will we learn?” Takeda Science Foundation Symposium on Bioscience “Cell Death: What have we learned and what will we learn?” 2008/12 英語 口頭発表(招待・特別) 公開
The COP9/Signalosome increases the efficiency of pVHL-containing ubiquitin ligase–mediated HIF-alpha ubiquitination.[招待あり] The COP9/Signalosome increases the efficiency of pVHL-containing ubiquitin ligase–mediated HIF-alpha ubiquitination. [招待あり] The COP9/Signalosome increases the efficiency of pVHL-containing ubiquitin ligase–mediated HIF-alpha ubiquitination. [招待あり] ZOMESV: The Fifth International Symposium on the COP9 signalosome, Proteasome and eIF3: At the interface between signaling and proteolysis ZOMESV: The Fifth International Symposium on the COP9 signalosome, Proteasome and eIF3: At the interface between signaling and proteolysis ZOMESV: The Fifth International Symposium on the COP9 signalosome, Proteasome and eIF3: At the interface between signaling and proteolysis 2008/11 英語 口頭発表(招待・特別) 公開
Disturbed heme metabolism in the liver of fatigue model rats and its involvement of fatigue.[招待あり] Disturbed heme metabolism in the liver of fatigue model rats and its involvement of fatigue. [招待あり] Disturbed heme metabolism in the liver of fatigue model rats and its involvement of fatigue. [招待あり] The International Conference on Fatigue Science The International Conference on Fatigue Science The International Conference on Fatigue Science 2008/09 英語 口頭発表(招待・特別) 公開
Involvement of the mitochondrial Fe-S cluster biogenetic system in the regulation of cellular iron metabolism.[招待あり] Involvement of the mitochondrial Fe-S cluster biogenetic system in the regulation of cellular iron metabolism. [招待あり] Involvement of the mitochondrial Fe-S cluster biogenetic system in the regulation of cellular iron metabolism. [招待あり] 3nd International Workshop on Cell Regulations in Division and Arrest under Stress 3nd International Workshop on Cell Regulations in Division and Arrest under Stress 3nd International Workshop on Cell Regulations in Division and Arrest under Stress 2008/04 英語 口頭発表(招待・特別) 公開
Mechanism underlying the iron-dependent regulation of the iron-sensing transcription factor Aft1p in Saccharomyces cerevisiae.[招待あり] Mechanism underlying the iron-dependent regulation of the iron-sensing transcription factor Aft1p in Saccharomyces cerevisiae. [招待あり] Mechanism underlying the iron-dependent regulation of the iron-sensing transcription factor Aft1p in Saccharomyces cerevisiae. [招待あり] Okazaki Conference Molecular Science and Chemical Biology of Biomolecular Function Okazaki Conference Molecular Science and Chemical Biology of Biomolecular Function Okazaki Conference Molecular Science and Chemical Biology of Biomolecular Function 2007/11 英語 口頭発表(招待・特別) 公開
Linear ubiquitination of NEMO triggers NF-kappaB activation. Linear ubiquitination of NEMO triggers NF-kappaB activation. Linear ubiquitination of NEMO triggers NF-kappaB activation. The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation” The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation” The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation” 2007/09 英語 口頭発表(一般) 公開
Identification of a ligase complex polymerizing linear polyubiquitin chains and its physiological role.[招待あり] Identification of a ligase complex polymerizing linear polyubiquitin chains and its physiological role. [招待あり] Identification of a ligase complex polymerizing linear polyubiquitin chains and its physiological role. [招待あり] The Fourth NIBB-EMBL Symposium The Fourth NIBB-EMBL Symposium The Fourth NIBB-EMBL Symposium 2006/12 英語 口頭発表(招待・特別) 公開
Involvement of heme regulatory motif in iron-sensing, ubiquitination and degradation of IRP2[招待あり] Involvement of heme regulatory motif in iron-sensing, ubiquitination and degradation of IRP2 [招待あり] Involvement of heme regulatory motif in iron-sensing, ubiquitination and degradation of IRP2 [招待あり] Symposium in EABS & 44th Annual Meeting of the Biophysical Society of Japan Symposium in EABS & 44th Annual Meeting of the Biophysical Society of Japan Symposium in EABS & 44th Annual Meeting of the Biophysical Society of Japan 2006/11 英語 口頭発表(招待・特別) 公開
Involvement of Heme Regulatory Motif in Iron-sensing, Ubiquitination and Degradation of IRP2.[招待あり] Involvement of Heme Regulatory Motif in Iron-sensing, Ubiquitination and Degradation of IRP2. [招待あり] Involvement of Heme Regulatory Motif in Iron-sensing, Ubiquitination and Degradation of IRP2. [招待あり] The 20th IUBMB The 20th IUBMB The 20th IUBMB 2006/06 英語 口頭発表(一般) 公開
Mechanism underlying oxidation-induced ubiquitylation.[招待あり] Mechanism underlying oxidation-induced ubiquitylation. [招待あり] Mechanism underlying oxidation-induced ubiquitylation. [招待あり] The Hebrew University of Jerusalem, The Institute for Advances Studies Workshop “Ubiquitin in Cancer and in Chronic Diseases” The Hebrew University of Jerusalem, The Institute for Advances Studies Workshop “Ubiquitin in Cancer and in Chronic Diseases” The Hebrew University of Jerusalem, The Institute for Advances Studies Workshop “Ubiquitin in Cancer and in Chronic Diseases” 2004/05 英語 口頭発表(招待・特別) 公開
Identification of HOIL-1 ubiquitin ligase that recognizes Heme Oxidized IRP2.[招待あり] Identification of HOIL-1 ubiquitin ligase that recognizes Heme Oxidized IRP2. [招待あり] Identification of HOIL-1 ubiquitin ligase that recognizes Heme Oxidized IRP2. [招待あり] 3rd General Meeting of the International Proteolytic Society. 3rd General Meeting of the International Proteolytic Society. 3rd General Meeting of the International Proteolytic Society. 2003/11 英語 口頭発表(招待・特別) 公開
Identification of the ubiquitin-protein ligase that recognizes heme-oxidized IRP2 Identification of the ubiquitin-protein ligase that recognizes heme-oxidized IRP2 Identification of the ubiquitin-protein ligase that recognizes heme-oxidized IRP2 World Congress on Iron Metabolism World Congress on Iron Metabolism World Congress on Iron Metabolism 2003/05 英語 口頭発表(一般) 公開
Identification of the ubiquitin-protein ligase that recognized oxidized IRP2. Identification of the ubiquitin-protein ligase that recognized oxidized IRP2. Identification of the ubiquitin-protein ligase that recognized oxidized IRP2. Cold Spring Harbor Laboratory Symposium “Ubiquitin family” Cold Spring Harbor Laboratory Symposium “Ubiquitin family” Cold Spring Harbor Laboratory Symposium “Ubiquitin family” 2003/04 英語 口頭発表(一般) 公開
Identification of an ubiquitin-protein ligase recognizing oxidized proteins.[招待あり] Identification of an ubiquitin-protein ligase recognizing oxidized proteins. [招待あり] Identification of an ubiquitin-protein ligase recognizing oxidized proteins. [招待あり] The 3rd International Symposium on Autophagy The 3rd International Symposium on Autophagy The 3rd International Symposium on Autophagy 2002/09 英語 口頭発表(招待・特別) 公開
Isolation of the candidate of E3, which recognizes oxidized IRP2 Isolation of the candidate of E3, which recognizes oxidized IRP2 Isolation of the candidate of E3, which recognizes oxidized IRP2 FASEB summer research conference ”Ubiquitin and intracellular protein degradation” FASEB summer research conference ”Ubiquitin and intracellular protein degradation” FASEB summer research conference ”Ubiquitin and intracellular protein degradation” 2001/06 英語 口頭発表(一般) 公開
Identification of the von Hippel-Lindau tumor suppressor protein as part of an active E3 ubiquitin ligase complex[招待あり] Identification of the von Hippel-Lindau tumor suppressor protein as part of an active E3 ubiquitin ligase complex [招待あり] Identification of the von Hippel-Lindau tumor suppressor protein as part of an active E3 ubiquitin ligase complex [招待あり] The EMBO workshop "ubiquitin-proteasome pathway and cellular regulation" The EMBO workshop "ubiquitin-proteasome pathway and cellular regulation" The EMBO workshop "ubiquitin-proteasome pathway and cellular regulation" 2000/05 英語 口頭発表(招待・特別) 公開
Oxidation-induced ubiquitination of iron regulatory protein 2: Implications for degradation of oxidized proteins.[招待あり] Oxidation-induced ubiquitination of iron regulatory protein 2: Implications for degradation of oxidized proteins. [招待あり] Oxidation-induced ubiquitination of iron regulatory protein 2: Implications for degradation of oxidized proteins. [招待あり] The 6th CGGH symposium The 6th CGGH symposium The 6th CGGH symposium 1999/05 英語 公開
Oxidative modification is the signal of the iron-dependent degradation of iron regulatory protein 2 (IRP2) via uhiquitin proteasome pathway. Oxidative modification is the signal of the iron-dependent degradation of iron regulatory protein 2 (IRP2) via uhiquitin proteasome pathway. Oxidative modification is the signal of the iron-dependent degradation of iron regulatory protein 2 (IRP2) via uhiquitin proteasome pathway. FASEB summer reserch conference ”Ubiquitin and protein degradation” FASEB summer reserch conference ”Ubiquitin and protein degradation” FASEB summer reserch conference ”Ubiquitin and protein degradation” 1997/06 英語 口頭発表(一般) 公開
Iron dependent degradation of a second iron-responsive element binding protein, IRP2(iron regulatory protein 2): implication of ubiquitin system. Iron dependent degradation of a second iron-responsive element binding protein, IRP2(iron regulatory protein 2): implication of ubiquitin system. Iron dependent degradation of a second iron-responsive element binding protein, IRP2(iron regulatory protein 2): implication of ubiquitin system. FASEB summer research conference”Ubiquitin and protein degradation” FASEB summer research conference”Ubiquitin and protein degradation” FASEB summer research conference”Ubiquitin and protein degradation” 1995/06 英語 口頭発表(一般) 公開

  • <<
  • >>
  • 表示
タイトル言語:
特許
発明者 発明者(日本語) 発明者(英語) 発明の名称 発明の名称(日本語) 発明の名称(英語) 審査の段階 番号 年月 公開
岩井 一宏 岩井 一宏 IWAI Kazuhiro UBIQUITIN LIGASE AND USE THEREOF UBIQUITIN LIGASE AND USE THEREOF UBIQUITIN LIGASE AND USE THEREOF 特許登録 特許8,56,094 B2 2013/10/01 公開
岩井 一宏 岩井 一宏 新規なユビキチンリガーゼおよびその利用 新規なユビキチンリガーゼおよびその利用 特許登録 特許5234865 2013/04/05 公開
1. 池田 恭治、石井 晴朗、岩井 一宏、伊東 昌子 1. 池田 恭治、石井 晴朗、岩井 一宏、伊東 昌子 破骨細胞制御剤とそのスクリーニング方法 破骨細胞制御剤とそのスクリーニング方法 特許出願 特願2007-151307 2007/06 公開
岩井 一宏 岩井 一宏 IWAI Kazuhiro UBIQUITIN LIGASE HAVING LINEAR POLYUBIQUITINATIONACTIVITY AND USE THEREOF UBIQUITIN LIGASE HAVING LINEAR POLYUBIQUITINATIONACTIVITY AND USE THEREOF UBIQUITIN LIGASE HAVING LINEAR POLYUBIQUITINATIONACTIVITY AND USE THEREOF 特許公表 特表217972 2015/12/25 公開
タイトル言語:
学術賞等
賞の名称(日本語) 賞の名称(英語) 授与組織名(日本語) 授与組織名(英語) 年月
日本医師会医学賞 Medical Award of The Japan Medical Association 日本医師会 The Japan Medical Association 2015/11/01
持田記念学術賞 Academic Award of the Mochida Memorial Foundation 持田記念医学薬学振興財団 Mochida Memorial Foundation for Medical and Pharmaceutical Research 2017/11/09
外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
挑戦的萌芽研究 代表 NF-κB活性化を制御するユビキチンリガーゼ活性調節薬の開発 2012〜2013
新学術領域研究(研究領域提案型) 代表 ユビキチンネオバイオロジー:拡大するタンパク質制御システム 2012〜2016
新学術領域研究(研究領域提案型) 代表 直鎖状ポリユビキチン鎖の選択的生成機構とその役割 2012〜2016
新学術領域研究(研究領域提案型) 代表 ユビキチンネオバイオロジー:拡大するタンパク質制御システム 2012/04/01〜2017/03/31
新学術領域研究(研究領域提案型) 代表 直鎖状ポリユビキチン鎖の選択的生成機構とその役割 2012/04/01〜2017/03/31
基盤研究(A) 代表 直鎖状ポリユビキチン鎖生成リガーゼの機能とその異常による疾患発症機構 2013〜2015
挑戦的萌芽研究 代表 NF-κBを制御する直鎖状ユビキチン鎖生成調節薬の開発 (平成26年度分) 2014/04/01〜2015/03/31
新学術領域研究(研究領域提案型) 代表 直鎖状ポリユビキチン鎖の選択的生成機構とその役割 (平成26年度分) 2014/04/01〜2015/03/31
新学術領域研究(研究領域提案型) 代表 直鎖状ポリユビキチン鎖の選択的生成機構とその役割 (平成26年度分) 2014/04/01〜2015/03/31
新学術領域研究(研究領域提案型) 代表 ユビキチンネオバイオロジー:拡大するタンパク質制御システム (平成26年度分) 2014/04/01〜2015/03/31
基盤研究(A) 代表 直鎖状ポリユビキチン鎖生成リガーゼの機能とその異常による疾患発症機構 (平成26年度分) 2014/04/01〜2015/03/31
基盤研究(A) 代表 直鎖状ポリユビキチン鎖生成リガーゼの機能とその異常による疾患発症機構 (平成27年度分) 2015/04/01〜2016/03/31
新学術領域研究(研究領域提案型) 代表 ユビキチンネオバイオロジー:拡大するタンパク質制御システム (平成27年度分) 2015/04/01〜2016/03/31
新学術領域研究(研究領域提案型) 代表 直鎖状ポリユビキチン鎖の選択的生成機構とその役割 (平成27年度分) 2015/04/01〜2016/03/31
基盤研究(A) 代表 直鎖状ポリユビキチン鎖生成リガーゼの機能とその異常による疾患発症機構 (平成27年度分) 2015/04/01〜2016/03/31
挑戦的萌芽研究 代表 NF-κBを制御する直鎖状ユビキチン鎖生成調節薬の開発 (平成27年度分) 2015/04/01〜2016/03/31
新学術領域研究(研究領域提案型) 代表 ユビキチンネオバイオロジー:拡大するタンパク質制御システム (平成28年度分) 2016/04/01〜2017/03/31
新学術領域研究(研究領域提案型) 代表 直鎖状ポリユビキチン鎖の選択的生成機構とその役割 (平成28年度分) 2016/04/01〜2017/03/31
新学術領域研究(研究領域提案型) 代表 直鎖状ポリユビキチン鎖の選択的生成機構とその役割 (平成28年度分) 2016/04/01〜2017/03/31
基盤研究(A) 代表 直鎖状ポリユビキチン鎖生成リガーゼの機能とその異常による疾患発症機構 (平成28年度分) 2016/04/01〜2017/03/31
基盤研究(A) 代表 直鎖状ユビキチン鎖による生体制御機構の解析 (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(S) 代表 直鎖状ユビキチン鎖を生成するLUBACリガーゼの統括的研究 (平成29年度分) 2017/04/01〜2018/03/31
新学術領域研究(研究領域提案型) 代表 ユビキチンネオバイオロジー:拡大するタンパク質制御システム (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(S) 代表 直鎖状ユビキチン鎖を生成するLUBACリガーゼの統括的研究 (平成30年度分) 2018/04/01〜2019/03/31
新学術領域研究(研究領域提案型) 代表 ケモテクノロジーを利用したユビキチン鎖の機能解析と制御 (平成30年度分) 2018/04/01〜2019/03/31

  • <<
  • >>
  • 表示
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
A4ab 生理学・同実習 Physiology 後期後半 医学部 2013/04〜2014/03
A4a 生理学 Physiology 後期後半 医学部 2014/04〜2015/03
A4b 生理学実習 Laboratory Course in Physiology 後期後半 医学部 2014/04〜2015/03
生理学 I Physiology I 後期不定 医学研究科 2014/04〜2015/03
生理学 II Physiology II 後期不定 医学研究科 2014/04〜2015/03
生理学 Physiology 後期不定 医学研究科 2014/04〜2015/03
A4a 生理学 Physiology 後期後半 医学部 2015/04〜2016/03
A4b 生理学実習 Laboratory Course in Physiology 後期後半 医学部 2015/04〜2016/03
生理学 II Physiology II 後期不定 医学研究科 2015/04〜2016/03
生理学 I Physiology I 後期不定 医学研究科 2015/04〜2016/03
生理学 Physiology 後期不定 医学研究科 2015/04〜2016/03
生理学 Physiology 後期 工学研究科 2015/04〜2016/03
A4a 生理学 Physiology 後期後半 医学部 2016/04〜2017/03
A4b 生理学実習 Laboratory Course in Physiology 後期後半 医学部 2016/04〜2017/03
生理学 II Physiology II 後期不定 医学研究科 2016/04〜2017/03
生理学 I Physiology I 後期不定 医学研究科 2016/04〜2017/03
生理学 Physiology 後期不定 医学研究科 2016/04〜2017/03
生理学 Physiology 後期 工学研究科 2016/04〜2017/03
A4a 生理学 Physiology 後期後半 医学部 2018/04〜2019/03
A4b 生理学実習 Laboratory Course in Physiology 後期後半 医学部 2018/04〜2019/03
B5a 生理学 Physiology 後期前半 医学部 2018/04〜2019/03
B5b 生理学実習 Laboratory Course in Physiology 後期前半 医学部 2018/04〜2019/03
生理学II Physiology II 前期後半 医学部(人間健康科学科) 2018/04〜2019/03
生理学 II Physiology II 後期不定 医学研究科 2018/04〜2019/03
生理学 I Physiology I 後期不定 医学研究科 2018/04〜2019/03
生理学 Physiology 後期不定 医学研究科 2018/04〜2019/03
A4a 生理学 Physiology 後期後半 医学部 2019/04〜2020/03
A4b 生理学実習 Laboratory Course in Physiology 後期後半 医学部 2019/04〜2020/03
B5a 生理学 Physiology 後期前半 医学部 2019/04〜2020/03
B5b 生理学実習 Laboratory Course in Physiology 後期前半 医学部 2019/04〜2020/03
生理学II Physiology II 前期後半 医学部(人間健康科学科) 2019/04〜2020/03

  • <<
  • >>
  • 表示
全学運営(役職等)
役職名 期間
学生生活委員会 委員 2013/04/01〜2015/03/31
奨学金返還免除候補者選考委員会 委員 2013/04/01〜2015/03/31
企画委員会 委員 2016/10/01〜2018/09/30
国際高等教育院 企画評価専門委員会 生物学部会 委員 2015/05/01〜2017/04/30
教育研究評議会 評議員 2017/10/01〜2019/03/31
医学研究科 研究科長 2018/10/01〜2020/09/30
医学部 学部長 2018/10/01〜2020/09/30
医学教育・国際化推進センター長 2018/10/01〜2020/09/30
企画委員会 委員 2018/10/01〜2020/09/30
企画委員会 若手重点戦略定員専門委員会 委員 2018/07/24〜2020/09/30
京都大学情報環境整備委員会 委員 2018/10/01〜2021/03/31
全学情報セキュリティ委員会 委員 2018/10/01〜
国際高等教育院 教養・共通教育協議会 協議員 2018/10/01〜2020/09/30
国際高等教育院 大学院共通・横断教育基盤協議会 協議員 2018/10/01〜2020/09/30
京都大学スーパーグローバルコース実施運営協議会 委員 2018/10/01〜2020/03/31
大学院横断教育プログラム推進センター運営協議会 協議員 2018/10/01〜2020/03/31
入学試験委員会 委員 2018/10/01〜2020/09/30
競争的資金等の不正防止計画推進室 室員 2019/04/01〜2020/09/30
研究公正推進委員会 委員 2019/04/01〜2020/09/30
研究公正委員会 委員 2018/10/01〜2020/09/30
京都大学利益相反マネジメント委員会 委員 2018/10/01〜2020/09/30
産学共同実用化促進事業実施委員会 委員 2018/10/01〜2019/09/09
産官学連携本部運営協議会 委員 2018/10/01〜2020/09/30
環境安全保健委員会 委員 2019/04/01〜2021/03/31
教育研究評議会 評議員 2018/10/01〜2020/09/30
部局長会議 2018/10/01〜2020/09/30
研究科長部会 2018/10/01〜2020/09/30
基金運営委員会 委員 2018/10/01〜2020/09/30
教員活動評価委員会 委員 2018/10/01〜2019/03/31
核燃料物質専門委員会
原子力研究整備委員会
情報環境整備委員会 2019/04/01〜2021/03/31
創立百二十五周年記念事業委員会幹事会 2018/10/01〜2020/09/30
京都大学学術研究支援室運営委員会 委員 2018/10/01〜2020/03/31
京都大学研究者情報整備委員会 2018/10/01〜2020/03/31
環境安全保健機構運営協議会協議員 2018/10/01〜2020/06/30
全学教員部教員選考会議(環境安全保健機構)構成員 2019/02/06〜

  • <<
  • >>
  • 表示
部局運営(役職等)
役職名 期間
人事連絡委員会 2012/10/01〜2020/09/30
副研究科長 2017/10/01〜2019/03/31
医学図書館図書連絡委員 2013/09/01〜2015/03/31
医学研究科・医学部将来計画検討委員会 2017/10/01〜2020/03/31
医学研究科等防犯カメラ設置運用委員会 2013/04/01〜2020/09/30
医学研究科運営委員会 〜2018/03/31
管理体制委員会 2016/10/01〜2018/09/30
基礎系副専攻長 2013/04/01〜2015/06/10
M.D./Ph.D.コース運営委員会 2017/04/01〜
大倉辰三郎・喜美奨学金 選考小委員会 2015/04/01〜2018/09/30
動物実験施設管理委員会 2018/10/01〜2020/09/30
学務委員会 2018/04/01〜2020/09/30
寄附講座運営委員会(創薬医学) 2016/04/01〜2020/03/31
寄附講座運営委員会(免疫ゲノム医学) 2016/04/01〜2020/03/31
教員人事活性化委員会 2015/09/24〜
再生医科学研究所運営委員会 2016/04/01〜2018/03/31
病院長・評議員 2017/10/01〜2019/03/31
医学研究科・医学部財務委員会
ウイルス・再生医科学研究所・再生医学・再生医療の先端融合的共同研究拠点運営委員会 2018/04/01〜2020/03/31
医学図書館図書連絡委員 2018/04/01〜2019/03/31
医学研究科長・医学部長 2018/10/01〜2020/09/30
附属医学教育・国際化推進センター 2018/10/01〜2020/09/30
医学教育・国際化推進センター運営委員会
医学図書館図書運営委員 2017/10/01〜2020/09/30
放射線障害防止委員会
学術情報システム・情報セキュリティ委員会 2018/10/01〜2020/09/30
IFOM-KU 国際共同ラボ 運営委員会
京都大学医薬系総合研究棟管理運営委員会 2018/10/01〜2020/09/30
京都大学分子生物実験研究棟管理運営委員会
京都大学白眉センター運営委員会 2018/10/01〜2020/09/30
京都大学白眉センター伯楽会議委員 2018/12/01〜2020/06/30
大学院総合生存学館教授会(思修館協議会) 2018/10/01〜2020/09/30
ウイルス・再生医科学研究所諮問会議委員 2018/02/01〜2020/03/31

  • <<
  • >>
  • 表示
外国人訪問者受入れ
訪問者名 所属機関名 国名 期間
Aaron J. Ciechanover (Nobel Prize in Chemistry 2004) Technion-Israel Institute of Technology Israel 2016/11/27〜2016/12/10