三好 弘之

最終更新日時: 2020/07/30 17:55:57

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氏名(漢字/フリガナ/アルファベット表記)
三好 弘之/ミヨシ ヒロユキ/
所属部署・職名(部局/所属/講座等/職名)
医学部附属病院/先端医療研究開発機構/准教授
所属学会(国内)
学会名(日本語) 学会名(英語)
日本癌学会 Japanese Cancer Association
日本分子生物学会 The Molecular Biology Society of Japan
所属学会(海外)
学会名(英語) 国名
American Association for Cancer Research USA
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
博士(医学) 京都大学
出身学校・専攻等
大学名(日本語) 大学名(英語) 学部名(日本語) 学部名(英語) 学科名(日本語) 学科名(英語) 卒業区分
北海道大学 獣医学部獣医学科 卒業
職歴
期間 組織名(日本語) 組織名(英語) 職名(日本語) 職名(英語)
2002/10/01〜2008/03/31 京都大学医学研究科 Kyoto University Graduate School of Medicine 助手/助教 Assistant Professor
2008/04/01〜2012/12/31 ワシントン大学医学部病理免疫部門 Department of Pathology & Immunology, Washington University School of Medicine 博士研究員 Postdoctoral Research Associate
2013/01/01〜2014/10/31 ワシントン大学医学部病理免疫部門 Department of Pathology & Immunology, Washington University School of Medicine インストラクター Instructor
2014/11/01〜2016/12/31 京都大学医学部附属病院 Kyoto University Hospital 特定准教授 Associate Professor
2017/01/01〜2019/09/30 京都大学産官学連携本部 Kyoto University Office of Society-Academia Collaboration for Innovation 特任准教授 Associate Professor
2019/10/01〜 京都大学医学部附属病院 先端医療研究開発機構 Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital 准教授 Associate professor
ORCID ID
https://orcid.org/0000-0001-7400-0714
researchmap URL
https://researchmap.jp/7000011426
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Takehito Yamamoto, Hiroyuki Miyoshi, Fumihiko Kakizaki, Hisatsugu Maekawa, Tadayoshi Yamaura, Tomonori Morimoto, Toshiro Katayama, Kenji Kawada, Yoshiharu Sakai, M. Mark Taketo Takehito Yamamoto, Hiroyuki Miyoshi, Fumihiko Kakizaki, Hisatsugu Maekawa, Tadayoshi Yamaura, Tomonori Morimoto, Toshiro Katayama, Kenji Kawada, Yoshiharu Sakai, M. Mark Taketo Takehito Yamamoto, Hiroyuki Miyoshi, Fumihiko Kakizaki, Hisatsugu Maekawa, Tadayoshi Yamaura, Tomonori Morimoto, Toshiro Katayama, Kenji Kawada, Yoshiharu Sakai, M. Mark Taketo Chemosensitivity of Patient-Derived Cancer Stem Cells Identifies Colorectal Cancer Patients with Potential Benefit from FGFR Inhibitor Therapy Chemosensitivity of Patient-Derived Cancer Stem Cells Identifies Colorectal Cancer Patients with Potential Benefit from FGFR Inhibitor Therapy Chemosensitivity of Patient-Derived Cancer Stem Cells Identifies Colorectal Cancer Patients with Potential Benefit from FGFR Inhibitor Therapy Cancers, 12, 8, 2010-2010 Cancers, 12, 8, 2010-2010 Cancers, 12, 8, 2010-2010 2020/07/22 研究論文(学術雑誌) 公開
Nobuyuki Kakiuchi, Kenichi Yoshida, Motoi Uchino, Takako Kihara, Kotaro Akaki, Yoshikage Inoue, Kenji Kawada, Satoshi Nagayama, Akira Yokoyama, Shuji Yamamoto, Minoru Matsuura, Takahiro Horimatsu, Tomonori Hirano, Norihiro Goto, Yasuhide Takeuchi, Yotaro Ochi, Yusuke Shiozawa, Yasunori Kogure, Yosaku Watatani, Yoichi Fujii, Soo Ki Kim, Ayana Kon, Keisuke Kataoka, Tetsuichi Yoshizato, Masahiro M Nakagawa, Akinori Yoda, Yasuhito Nanya, Hideki Makishima, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Eiji Sugihara, Taka-Aki Sato, Takashi Maruyama, Hiroyuki Miyoshi, Makoto Mark Taketo, Jun Oishi, Ryosaku Inagaki, Yutaka Ueda, Shinya Okamoto, Hideaki Okajima, Yoshiharu Sakai, Takaki Sakurai, Hironori Haga, Seiichi Hirota, Hiroki Ikeuchi, Hiroshi Nakase, Hiroyuki Marusawa, Tsutomu Chiba, Osamu Takeuchi, Satoru Miyano, Hiroshi Seno, Seishi Ogawa Nobuyuki Kakiuchi, Kenichi Yoshida, Motoi Uchino, Takako Kihara, Kotaro Akaki, Yoshikage Inoue, Kenji Kawada, Satoshi Nagayama, Akira Yokoyama, Shuji Yamamoto, Minoru Matsuura, Takahiro Horimatsu, Tomonori Hirano, Norihiro Goto, Yasuhide Takeuchi, Yotaro Ochi, Yusuke Shiozawa, Yasunori Kogure, Yosaku Watatani, Yoichi Fujii, Soo Ki Kim, Ayana Kon, Keisuke Kataoka, Tetsuichi Yoshizato, Masahiro M Nakagawa, Akinori Yoda, Yasuhito Nanya, Hideki Makishima, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Eiji Sugihara, Taka-Aki Sato, Takashi Maruyama, Hiroyuki Miyoshi, Makoto Mark Taketo, Jun Oishi, Ryosaku Inagaki, Yutaka Ueda, Shinya Okamoto, Hideaki Okajima, Yoshiharu Sakai, Takaki Sakurai, Hironori Haga, Seiichi Hirota, Hiroki Ikeuchi, Hiroshi Nakase, Hiroyuki Marusawa, Tsutomu Chiba, Osamu Takeuchi, Satoru Miyano, Hiroshi Seno, Seishi Ogawa Nobuyuki Kakiuchi, Kenichi Yoshida, Motoi Uchino, Takako Kihara, Kotaro Akaki, Yoshikage Inoue, Kenji Kawada, Satoshi Nagayama, Akira Yokoyama, Shuji Yamamoto, Minoru Matsuura, Takahiro Horimatsu, Tomonori Hirano, Norihiro Goto, Yasuhide Takeuchi, Yotaro Ochi, Yusuke Shiozawa, Yasunori Kogure, Yosaku Watatani, Yoichi Fujii, Soo Ki Kim, Ayana Kon, Keisuke Kataoka, Tetsuichi Yoshizato, Masahiro M Nakagawa, Akinori Yoda, Yasuhito Nanya, Hideki Makishima, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Eiji Sugihara, Taka-Aki Sato, Takashi Maruyama, Hiroyuki Miyoshi, Makoto Mark Taketo, Jun Oishi, Ryosaku Inagaki, Yutaka Ueda, Shinya Okamoto, Hideaki Okajima, Yoshiharu Sakai, Takaki Sakurai, Hironori Haga, Seiichi Hirota, Hiroki Ikeuchi, Hiroshi Nakase, Hiroyuki Marusawa, Tsutomu Chiba, Osamu Takeuchi, Satoru Miyano, Hiroshi Seno, Seishi Ogawa Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis. Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis. Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis. Nature, 577, 7789, 260-265 Nature, 577, 7789, 260-265 Nature, 577, 7789, 260-265 2020/01 英語 公開
Aya Nishiuchi, Shigeo Hisamori, Masazumi Sakaguchi, Keita Fukuyama, Nobuaki Hoshino, Yoshiro Itatani, Shusaku Honma, Hisatsugu Maekawa, Tatsuto Nishigori, Shigeru Tsunoda, Kazutaka Obama, Hiroyuki Miyoshi, Yohei Shimono, M Mark Taketo, Yoshiharu Sakai Aya Nishiuchi, Shigeo Hisamori, Masazumi Sakaguchi, Keita Fukuyama, Nobuaki Hoshino, Yoshiro Itatani, Shusaku Honma, Hisatsugu Maekawa, Tatsuto Nishigori, Shigeru Tsunoda, Kazutaka Obama, Hiroyuki Miyoshi, Yohei Shimono, M Mark Taketo, Yoshiharu Sakai Aya Nishiuchi, Shigeo Hisamori, Masazumi Sakaguchi, Keita Fukuyama, Nobuaki Hoshino, Yoshiro Itatani, Shusaku Honma, Hisatsugu Maekawa, Tatsuto Nishigori, Shigeru Tsunoda, Kazutaka Obama, Hiroyuki Miyoshi, Yohei Shimono, M Mark Taketo, Yoshiharu Sakai MicroRNA-9-5p-CDX2 Axis: A Useful Prognostic Biomarker for Patients with Stage II/III Colorectal Cancer. MicroRNA-9-5p-CDX2 Axis: A Useful Prognostic Biomarker for Patients with Stage II/III Colorectal Cancer. MicroRNA-9-5p-CDX2 Axis: A Useful Prognostic Biomarker for Patients with Stage II/III Colorectal Cancer. Cancers, 11, 12 Cancers, 11, 12 Cancers, 11, 12 2019/11/27 英語 公開
Norihiro Goto, Akihisa Fukuda, Yuichi Yamaga, Takaaki Yoshikawa, Takahisa Maruno, Hisatsugu Maekawa, Susumu Inamoto, Kenji Kawada, Yoshiharu Sakai, Hiroyuki Miyoshi, Makoto Mark Taketo, Tsutomu Chiba, Hiroshi Seno Norihiro Goto, Akihisa Fukuda, Yuichi Yamaga, Takaaki Yoshikawa, Takahisa Maruno, Hisatsugu Maekawa, Susumu Inamoto, Kenji Kawada, Yoshiharu Sakai, Hiroyuki Miyoshi, Makoto Mark Taketo, Tsutomu Chiba, Hiroshi Seno Norihiro Goto, Akihisa Fukuda, Yuichi Yamaga, Takaaki Yoshikawa, Takahisa Maruno, Hisatsugu Maekawa, Susumu Inamoto, Kenji Kawada, Yoshiharu Sakai, Hiroyuki Miyoshi, Makoto Mark Taketo, Tsutomu Chiba, Hiroshi Seno Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells. Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells. Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America, 116, 26, 12996-13005 Proceedings of the National Academy of Sciences of the United States of America, 116, 26, 12996-13005 Proceedings of the National Academy of Sciences of the United States of America, 116, 26, 12996-13005 2019/06/25 英語 公開
山浦 忠能, 河田 健二, 前川 久継, 森本 智紀, 山本 健人, 三好 弘之, 坂井 義治, 武藤 誠 山浦 忠能, 河田 健二, 前川 久継, 森本 智紀, 山本 健人, 三好 弘之, 坂井 義治, 武藤 誠 大腸癌診療におけるprecision medicine 患者組織由来の癌幹細胞Spheroidから抽出した高純度DNA検体による大腸癌マイクロサテライト不安性検査 大腸癌診療におけるprecision medicine 患者組織由来の癌幹細胞Spheroidから抽出した高純度DNA検体による大腸癌マイクロサテライト不安性検査 日本外科学会定期学術集会抄録集, 119回, WS-5 日本外科学会定期学術集会抄録集, 119回, WS-5 , 119回, WS-5 2019/04 日本語 公開
Yukiko Hiramatsu, Akihisa Fukuda, Satoshi Ogawa, Norihiro Goto, Kozo Ikuta, Motoyuki Tsuda, Yoshihide Matsumoto, Yoshito Kimura, Takuto Yoshioka, Yutaka Takada, Takahisa Maruno, Yuta Hanyu, Tatsuaki Tsuruyama, Zhong Wang, Haruhiko Akiyama, Shigeo Takaishi, Hiroyuki Miyoshi, Makoto Mark Taketo, Tsutomu Chiba, Hiroshi Seno Yukiko Hiramatsu, Akihisa Fukuda, Satoshi Ogawa, Norihiro Goto, Kozo Ikuta, Motoyuki Tsuda, Yoshihide Matsumoto, Yoshito Kimura, Takuto Yoshioka, Yutaka Takada, Takahisa Maruno, Yuta Hanyu, Tatsuaki Tsuruyama, Zhong Wang, Haruhiko Akiyama, Shigeo Takaishi, Hiroyuki Miyoshi, Makoto Mark Taketo, Tsutomu Chiba, Hiroshi Seno Yukiko Hiramatsu, Akihisa Fukuda, Satoshi Ogawa, Norihiro Goto, Kozo Ikuta, Motoyuki Tsuda, Yoshihide Matsumoto, Yoshito Kimura, Takuto Yoshioka, Yutaka Takada, Takahisa Maruno, Yuta Hanyu, Tatsuaki Tsuruyama, Zhong Wang, Haruhiko Akiyama, Shigeo Takaishi, Hiroyuki Miyoshi, Makoto Mark Taketo, Tsutomu Chiba, Hiroshi Seno Arid1a is essential for intestinal stem cells through Sox9 regulation. Arid1a is essential for intestinal stem cells through Sox9 regulation. Arid1a is essential for intestinal stem cells through Sox9 regulation. Proceedings of the National Academy of Sciences of the United States of America, 116, 5, 1704-1713 Proceedings of the National Academy of Sciences of the United States of America, 116, 5, 1704-1713 Proceedings of the National Academy of Sciences of the United States of America, 116, 5, 1704-1713 2019/01/29 英語 公開
Tadayoshi Yamaura, Hiroyuki Miyoshi, Hisatsugu Maekawa, Tomonori Morimoto, Takehito Yamamoto, Fumihiko Kakizaki, Koichiro Higasa, Kenji Kawada, Fumihiko Matsuda, Yoshiharu Sakai, M Mark Taketo Tadayoshi Yamaura, Hiroyuki Miyoshi, Hisatsugu Maekawa, Tomonori Morimoto, Takehito Yamamoto, Fumihiko Kakizaki, Koichiro Higasa, Kenji Kawada, Fumihiko Matsuda, Yoshiharu Sakai, M Mark Taketo Tadayoshi Yamaura, Hiroyuki Miyoshi, Hisatsugu Maekawa, Tomonori Morimoto, Takehito Yamamoto, Fumihiko Kakizaki, Koichiro Higasa, Kenji Kawada, Fumihiko Matsuda, Yoshiharu Sakai, M Mark Taketo Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells. Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells. Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells. Oncotarget, 9, 101, 37534-37548 Oncotarget, 9, 101, 37534-37548 Oncotarget, 9, 101, 37534-37548 2018/12/25 英語 研究論文(学術雑誌) 公開
Hisatsugu Maekawa, Hiroyuki Miyoshi, Tadayoshi Yamaura, Yoshiro Itatani, Kenji Kawada, Yoshiharu Sakai, M Mark Taketo Hisatsugu Maekawa, Hiroyuki Miyoshi, Tadayoshi Yamaura, Yoshiro Itatani, Kenji Kawada, Yoshiharu Sakai, M Mark Taketo Hisatsugu Maekawa, Hiroyuki Miyoshi, Tadayoshi Yamaura, Yoshiro Itatani, Kenji Kawada, Yoshiharu Sakai, M Mark Taketo A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor-Initiating Cells. A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor-Initiating Cells. A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor-Initiating Cells. Molecular cancer therapeutics, 17, 10, 2187-2196 Molecular cancer therapeutics, 17, 10, 2187-2196 Molecular cancer therapeutics, 17, 10, 2187-2196 2018/10 英語 研究論文(学術雑誌) 公開
前川 久継, 三好 弘之, 板谷 喜朗, 河田 健二, 坂井 義治, 武藤 誠 前川 久継, 三好 弘之, 板谷 喜朗, 河田 健二, 坂井 義治, 武藤 誠 前川 久継, 三好 弘之, 板谷 喜朗, 河田 健二, 坂井 義治, 武藤 誠 患者由来大腸癌細胞のスフェロイド培養およびそのマウスモデルを用いた抗癌剤感受性試験(A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor Initiating Cells) 患者由来大腸癌細胞のスフェロイド培養およびそのマウスモデルを用いた抗癌剤感受性試験(A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor Initiating Cells) 患者由来大腸癌細胞のスフェロイド培養およびそのマウスモデルを用いた抗癌剤感受性試験(A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor Initiating Cells) 日本癌学会総会記事, 77回, 862-862 日本癌学会総会記事, 77回, 862-862 日本癌学会総会記事, 77回, 862-862 2018/09 英語 公開
三好 弘之, 前川 久継, 柿崎 文彦, 河田 健二, 坂井 義治, 武藤 誠 三好 弘之, 前川 久継, 柿崎 文彦, 河田 健二, 坂井 義治, 武藤 誠 三好 弘之, 前川 久継, 柿崎 文彦, 河田 健二, 坂井 義治, 武藤 誠 高効率で低コストの患者由来大腸がんスフェロイド培養法(An efficient and low-cost method for propagating patient-derived colorectal cancer spheroids) 高効率で低コストの患者由来大腸がんスフェロイド培養法(An efficient and low-cost method for propagating patient-derived colorectal cancer spheroids) 高効率で低コストの患者由来大腸がんスフェロイド培養法(An efficient and low-cost method for propagating patient-derived colorectal cancer spheroids) 日本癌学会総会記事, 77回, 2114-2114 日本癌学会総会記事, 77回, 2114-2114 日本癌学会総会記事, 77回, 2114-2114 2018/09 英語 公開
Aoyama N, Miyoshi H, Miyachi H, Sonoshita M, Okabe M, Taketo MM Aoyama N, Miyoshi H, Miyachi H, Sonoshita M, Okabe M, Taketo MM Aoyama N, Miyoshi H, Miyachi H, Sonoshita M, Okabe M, Taketo MM Transgenic mice that accept Luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies Transgenic mice that accept Luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies Transgenic mice that accept Luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies Genes to Cells Genes to Cells Genes to Cells 2018/05 英語 研究論文(学術雑誌) 公開
Hiroyuki Miyoshi, Hisatsugu Maekawa, Fumihiko Kakizaki, Tadayoshi Yamaura, Kenji Kawada, Yoshiharu Sakai, M Mark Taketo Hiroyuki Miyoshi, Hisatsugu Maekawa, Fumihiko Kakizaki, Tadayoshi Yamaura, Kenji Kawada, Yoshiharu Sakai, M Mark Taketo Hiroyuki Miyoshi, Hisatsugu Maekawa, Fumihiko Kakizaki, Tadayoshi Yamaura, Kenji Kawada, Yoshiharu Sakai, M Mark Taketo An improved method for culturing patient-derived colorectal cancer spheroids. An improved method for culturing patient-derived colorectal cancer spheroids. An improved method for culturing patient-derived colorectal cancer spheroids. Oncotarget, 9, 31, 21950-21964 Oncotarget, 9, 31, 21950-21964 Oncotarget, 9, 31, 21950-21964 2018/04/24 英語 研究論文(学術雑誌) 公開
Norihiro Goto, Taro Ueo, Akihisa Fukuda, Kenji Kawada, Yoshiharu Sakai, Hiroyuki Miyoshi, Makoto Mark Taketo, Tsutomu Chiba, Hiroshi Seno Norihiro Goto, Taro Ueo, Akihisa Fukuda, Kenji Kawada, Yoshiharu Sakai, Hiroyuki Miyoshi, Makoto Mark Taketo, Tsutomu Chiba, Hiroshi Seno Norihiro Goto, Taro Ueo, Akihisa Fukuda, Kenji Kawada, Yoshiharu Sakai, Hiroyuki Miyoshi, Makoto Mark Taketo, Tsutomu Chiba, Hiroshi Seno Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine CANCER RESEARCH, 77, 13, 3442-3454 CANCER RESEARCH, 77, 13, 3442-3454 CANCER RESEARCH, 77, 13, 3442-3454 2017/07 英語 研究論文(学術雑誌) 公開
Miyoshi H, VanDussen KL, Malvin NP, Ryu SH, Wang Y, Sonnek NM, Lai CW, Stappenbeck TS Miyoshi H, VanDussen KL, Malvin NP, Ryu SH, Wang Y, Sonnek NM, Lai CW, Stappenbeck TS Hiroyuki Miyoshi, Kelli L. VanDussen, Nicole P. Malvin, Stacy H. Ryu, Yi Wang, Naomi M. Sonnek, Chin-Wen Lai, Thaddeus S. Stappenbeck Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium The EMBO journal, 36, 1, 5-24 The EMBO journal, 36, 1, 5-24 EMBO JOURNAL, 36, 1, 5-24 2017/01 英語 研究論文(学術雑誌) 公開
Hiroyuki Miyoshi Hiroyuki Miyoshi Hiroyuki Miyoshi Wnt-expressing cells in the intestines: guides for tissue remodeling Wnt-expressing cells in the intestines: guides for tissue remodeling Wnt-expressing cells in the intestines: guides for tissue remodeling JOURNAL OF BIOCHEMISTRY, 161, 1, 19-25 JOURNAL OF BIOCHEMISTRY, 161, 1, 19-25 JOURNAL OF BIOCHEMISTRY, 161, 1, 19-25 2017/01 英語 公開
Fumihiko Kakizaki, Masahiro Sonoshita, Hiroyuki Miyoshi, Yoshiro Itatani, Shinji Ito, Kenji Kawada, Yoshiharu Sakai, M. Mark Taketo Fumihiko Kakizaki, Masahiro Sonoshita, Hiroyuki Miyoshi, Yoshiro Itatani, Shinji Ito, Kenji Kawada, Yoshiharu Sakai, M. Mark Taketo Fumihiko Kakizaki, Masahiro Sonoshita, Hiroyuki Miyoshi, Yoshiro Itatani, Shinji Ito, Kenji Kawada, Yoshiharu Sakai, M. Mark Taketo Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2 Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2 Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2 CANCER SCIENCE, 107, 11, 1622-1631 CANCER SCIENCE, 107, 11, 1622-1631 CANCER SCIENCE, 107, 11, 1622-1631 2016/11 英語 研究論文(学術雑誌) 公開
Yoshihisa Okuchi, Masamichi Imajo, Rei Mizuno, Yuji Kamioka, Hiroyuki Miyoshi, Makoto Mark Taketo, Satoshi Nagayama, Yoshiharu Sakai, Michiyuki Matsuda Yoshihisa Okuchi, Masamichi Imajo, Rei Mizuno, Yuji Kamioka, Hiroyuki Miyoshi, Makoto Mark Taketo, Satoshi Nagayama, Yoshiharu Sakai, Michiyuki Matsuda Yoshihisa Okuchi, Masamichi Imajo, Rei Mizuno, Yuji Kamioka, Hiroyuki Miyoshi, Makoto Mark Taketo, Satoshi Nagayama, Yoshiharu Sakai, Michiyuki Matsuda Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis PLOS ONE, 11, 9, e0162300 PLOS ONE, 11, 9, e0162300 PLOS ONE, 11, 9, e0162300 2016/09 英語 研究論文(学術雑誌) 公開
Kazuhiko Uchiyama, Toshio Sakiyama, Takumu Hasebe, Mark W. Musch, Hiroyuki Miyoshi, Yasushi Nakagawa, Tong-Chuan He, Lev Lichtenstein, Yuji Naito, Yoshito Itoh, Toshikazu Yoshikawa, Bana Jabri, Thaddeus Stappenbeck, Eugene B. Chang Kazuhiko Uchiyama, Toshio Sakiyama, Takumu Hasebe, Mark W. Musch, Hiroyuki Miyoshi, Yasushi Nakagawa, Tong-Chuan He, Lev Lichtenstein, Yuji Naito, Yoshito Itoh, Toshikazu Yoshikawa, Bana Jabri, Thaddeus Stappenbeck, Eugene B. Chang Kazuhiko Uchiyama, Toshio Sakiyama, Takumu Hasebe, Mark W. Musch, Hiroyuki Miyoshi, Yasushi Nakagawa, Tong-Chuan He, Lev Lichtenstein, Yuji Naito, Yoshito Itoh, Toshikazu Yoshikawa, Bana Jabri, Thaddeus Stappenbeck, Eugene B. Chang Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development SCIENTIFIC REPORTS, 6, 32094 SCIENTIFIC REPORTS, 6, 32094 SCIENTIFIC REPORTS, 6, 32094 2016/08 英語 研究論文(学術雑誌) 公開
Kelli L. VanDussen, Jeffrey M. Marinshaw, Nurmohammad Shaikh, Hiroyuki Miyoshi, Clara Moon, Phillip I. Tarr, Matthew A. Ciorba, Thaddeus S. Stappenbeck Kelli L. VanDussen, Jeffrey M. Marinshaw, Nurmohammad Shaikh, Hiroyuki Miyoshi, Clara Moon, Phillip I. Tarr, Matthew A. Ciorba, Thaddeus S. Stappenbeck Kelli L. VanDussen, Jeffrey M. Marinshaw, Nurmohammad Shaikh, Hiroyuki Miyoshi, Clara Moon, Phillip I. Tarr, Matthew A. Ciorba, Thaddeus S. Stappenbeck Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays GUT, 64, 6, 911-920 GUT, 64, 6, 911-920 GUT, 64, 6, 911-920 2015/06 英語 研究論文(学術雑誌) 公開
Lulu Sun, Hiroyuki Miyoshi, Sofia Origanti, Timothy J. Nice, Alexandra C. Barger, Nicholas A. Manieri, Leslie A. Fogel, Anthony R. French, David Piwnica-Worms, Helen Piwnica-Worms, Herbert W. Virgin, Deborah J. Lenschow, Thaddeus S. Stappenbeck Lulu Sun, Hiroyuki Miyoshi, Sofia Origanti, Timothy J. Nice, Alexandra C. Barger, Nicholas A. Manieri, Leslie A. Fogel, Anthony R. French, David Piwnica-Worms, Helen Piwnica-Worms, Herbert W. Virgin, Deborah J. Lenschow, Thaddeus S. Stappenbeck Lulu Sun, Hiroyuki Miyoshi, Sofia Origanti, Timothy J. Nice, Alexandra C. Barger, Nicholas A. Manieri, Leslie A. Fogel, Anthony R. French, David Piwnica-Worms, Helen Piwnica-Worms, Herbert W. Virgin, Deborah J. Lenschow, Thaddeus S. Stappenbeck Type I Interferons Link Viral Infection to Enhanced Epithelial Turnover and Repair Type I Interferons Link Viral Infection to Enhanced Epithelial Turnover and Repair Type I Interferons Link Viral Infection to Enhanced Epithelial Turnover and Repair CELL HOST & MICROBE, 17, 1, 85-97 CELL HOST & MICROBE, 17, 1, 85-97 CELL HOST & MICROBE, 17, 1, 85-97 2015/01 英語 研究論文(学術雑誌) 公開
Thomas J. Hannan, Pacita L. Roberts, Terrence E. Riehl, Sjoerd van der Post, Jana M. Binkley, Drew J. Schwartz, Hiroyuki Miyoshi, Matthias Mack, Reto A. Schwendener, Thomas M. Hooton, Thaddeus S. Stappenbeck, Gunnar C. Hansson, William F. Stenson, Marco Colonna, Ann E. Stapleton, Scott J. Hultgren Thomas J. Hannan, Pacita L. Roberts, Terrence E. Riehl, Sjoerd van der Post, Jana M. Binkley, Drew J. Schwartz, Hiroyuki Miyoshi, Matthias Mack, Reto A. Schwendener, Thomas M. Hooton, Thaddeus S. Stappenbeck, Gunnar C. Hansson, William F. Stenson, Marco Colonna, Ann E. Stapleton, Scott J. Hultgren Thomas J. Hannan, Pacita L. Roberts, Terrence E. Riehl, Sjoerd van der Post, Jana M. Binkley, Drew J. Schwartz, Hiroyuki Miyoshi, Matthias Mack, Reto A. Schwendener, Thomas M. Hooton, Thaddeus S. Stappenbeck, Gunnar C. Hansson, William F. Stenson, Marco Colonna, Ann E. Stapleton, Scott J. Hultgren Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis EBIOMEDICINE, 1, 1, 46-57 EBIOMEDICINE, 1, 1, 46-57 EBIOMEDICINE, 1, 1, 46-57 2014/11 英語 研究論文(学術雑誌) 公開
C. Moon, K. L. VanDussen, H. Miyoshi, T. S. Stappenbeck C. Moon, K. L. VanDussen, H. Miyoshi, T. S. Stappenbeck C. Moon, K. L. VanDussen, H. Miyoshi, T. S. Stappenbeck Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis MUCOSAL IMMUNOLOGY, 7, 4, 818-828 MUCOSAL IMMUNOLOGY, 7, 4, 818-828 MUCOSAL IMMUNOLOGY, 7, 4, 818-828 2014/07 英語 研究論文(学術雑誌) 公開
Patel KK, Miyoshi H, Beatty WL, Head RD, Malvin NP, Cadwell K, Guan JL, Saitoh T, Akira S, Seglen PO, Dinauer MC, Virgin HW, Stappenbeck TS Patel KK, Miyoshi H, Beatty WL, Head RD, Malvin NP, Cadwell K, Guan JL, Saitoh T, Akira S, Seglen PO, Dinauer MC, Virgin HW, Stappenbeck TS Patel KK, Miyoshi H, Beatty WL, Head RD, Malvin NP, Cadwell K, Guan JL, Saitoh T, Akira S, Seglen PO, Dinauer MC, Virgin HW, Stappenbeck TS Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. The EMBO journal, 32, 24, 3130-3144 The EMBO journal, 32, 24, 3130-3144 The EMBO journal, 32, 24, 3130-3144 2013/12 公開
Hiroyuki Miyoshi, Thaddeus S. Stappenbeck Hiroyuki Miyoshi, Thaddeus S. Stappenbeck Hiroyuki Miyoshi, Thaddeus S. Stappenbeck In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture NATURE PROTOCOLS, 8, 12, 2471-2482 NATURE PROTOCOLS, 8, 12, 2471-2482 NATURE PROTOCOLS, 8, 12, 2471-2482 2013/12 英語 研究論文(学術雑誌) 公開
Hiroyuki Miyoshi, Thaddeus S. Stappenbeck Hiroyuki Miyoshi, Thaddeus S. Stappenbeck Hiroyuki Miyoshi, Thaddeus S. Stappenbeck The Young and the Wnt-less: Transplantable Fetal Intestinal Spheroids without Wnts The Young and the Wnt-less: Transplantable Fetal Intestinal Spheroids without Wnts The Young and the Wnt-less: Transplantable Fetal Intestinal Spheroids without Wnts CELL STEM CELL, 13, 6, 637-638 CELL STEM CELL, 13, 6, 637-638 CELL STEM CELL, 13, 6, 637-638 2013/12 英語 公開
Miyoshi H, Stappenbeck TS Miyoshi H, Stappenbeck TS Miyoshi H, Stappenbeck TS Counteracting stem cell expansion during wound repair: distinct roles of non-canonical Wnt and TGF-β. Counteracting stem cell expansion during wound repair: distinct roles of non-canonical Wnt and TGF-β. Counteracting stem cell expansion during wound repair: distinct roles of non-canonical Wnt and TGF-β. Cell cycle (Georgetown, Tex.), 12, 3, 387-388 Cell cycle (Georgetown, Tex.), 12, 3, 387-388 Cell cycle (Georgetown, Tex.), 12, 3, 387-388 2013/02 公開
Aly H, Rohatgi N, Marshall CA, Grossenheider TC, Miyoshi H, Stappenbeck TS, Matkovich SJ, McDaniel ML Aly H, Rohatgi N, Marshall CA, Grossenheider TC, Miyoshi H, Stappenbeck TS, Matkovich SJ, McDaniel ML Aly H, Rohatgi N, Marshall CA, Grossenheider TC, Miyoshi H, Stappenbeck TS, Matkovich SJ, McDaniel ML A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype. A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype. A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype. PloS one, 8, 6, e66131 PloS one, 8, 6, e66131 PloS one, 8, 6, e66131 2013 公開
Miyoshi H, Ajima R, Luo CT, Yamaguchi TP, Stappenbeck TS Miyoshi H, Ajima R, Luo CT, Yamaguchi TP, Stappenbeck TS Hiroyuki Miyoshi, Rieko Ajima, Christine T. Luo, Terry P. Yamaguchi, Thaddeus S. Stappenbeck Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury. Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury. Wnt5a Potentiates TGF-beta Signaling to Promote Colonic Crypt Regeneration After Tissue Injury Science (New York, N.Y.), 338, 6103, 108-113 Science (New York, N.Y.), 338, 6103, 108-113 SCIENCE, 338, 6103, 108-113 2012/10 英語 研究論文(学術雑誌) 公開
Nicholas A. Manieri, Monica R. Drylewicz, Hiroyuki Miyoshi, Thaddeus S. Stappenbeck Nicholas A. Manieri, Monica R. Drylewicz, Hiroyuki Miyoshi, Thaddeus S. Stappenbeck Nicholas A. Manieri, Monica R. Drylewicz, Hiroyuki Miyoshi, Thaddeus S. Stappenbeck Igf2bp1 Is Required for Full Induction of Ptgs2 mRNA in Colonic Mesenchymal Stem Cells in Mice Igf2bp1 Is Required for Full Induction of Ptgs2 mRNA in Colonic Mesenchymal Stem Cells in Mice Igf2bp1 Is Required for Full Induction of Ptgs2 mRNA in Colonic Mesenchymal Stem Cells in Mice GASTROENTEROLOGY, 143, 1, 110-U653 GASTROENTEROLOGY, 143, 1, 110-U653 GASTROENTEROLOGY, 143, 1, 110-U653 2012/07 英語 研究論文(学術雑誌) 公開
Satoshi Yamazaki, Hideo Ema, Goran Karlsson, Tomoyuki Yamaguchi, Hiroyuki Miyoshi, Seiji Shioda, Makoto M. Taketo, Stefan Karlsson, Atsushi Iwama, Hiromitsu Nakauchi Satoshi Yamazaki, Hideo Ema, Goran Karlsson, Tomoyuki Yamaguchi, Hiroyuki Miyoshi, Seiji Shioda, Makoto M. Taketo, Stefan Karlsson, Atsushi Iwama, Hiromitsu Nakauchi Satoshi Yamazaki, Hideo Ema, Goran Karlsson, Tomoyuki Yamaguchi, Hiroyuki Miyoshi, Seiji Shioda, Makoto M. Taketo, Stefan Karlsson, Atsushi Iwama, Hiromitsu Nakauchi Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche CELL, 147, 5, 1146-1158 CELL, 147, 5, 1146-1158 CELL, 147, 5, 1146-1158 2011/11 英語 研究論文(学術雑誌) 公開
Atsuko Deguchi, Hiroyuki Miyoshi, Yasushi Kojima, Katsuya Okawa, Masahiro Aoki, Makoto M. Taketo Atsuko Deguchi, Hiroyuki Miyoshi, Yasushi Kojima, Katsuya Okawa, Masahiro Aoki, Makoto M. Taketo Atsuko Deguchi, Hiroyuki Miyoshi, Yasushi Kojima, Katsuya Okawa, Masahiro Aoki, Makoto M. Taketo LKB1 Suppresses p21-activated Kinase-1 (PAK1) by Phosphorylation of Thr(109) in the p21-binding Domain LKB1 Suppresses p21-activated Kinase-1 (PAK1) by Phosphorylation of Thr(109) in the p21-binding Domain LKB1 Suppresses p21-activated Kinase-1 (PAK1) by Phosphorylation of Thr(109) in the p21-binding Domain JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 24, 18283-18290 JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 24, 18283-18290 JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 24, 18283-18290 2010/06 英語 研究論文(学術雑誌) 公開
Fumihiko Kakizaki, Koji Aoki, Hiroyuki Miyoshi, Nancy Carrasco, Masahiro Aoki, Makoto M. Taketo Fumihiko Kakizaki, Koji Aoki, Hiroyuki Miyoshi, Nancy Carrasco, Masahiro Aoki, Makoto M. Taketo Fumihiko Kakizaki, Koji Aoki, Hiroyuki Miyoshi, Nancy Carrasco, Masahiro Aoki, Makoto M. Taketo CDX Transcription Factors Positively Regulate Expression of Solute Carrier Family 5, Member 8 in the Colonic Epithelium CDX Transcription Factors Positively Regulate Expression of Solute Carrier Family 5, Member 8 in the Colonic Epithelium CDX Transcription Factors Positively Regulate Expression of Solute Carrier Family 5, Member 8 in the Colonic Epithelium GASTROENTEROLOGY, 138, 2, 627-635 GASTROENTEROLOGY, 138, 2, 627-635 GASTROENTEROLOGY, 138, 2, 627-635 2010/02 英語 研究論文(学術雑誌) 公開
Hiroyuki Miyoshi, Atsuko Deguchi, Masayuki Nakau, Yasushi Kojima, Akira Mori, Masanobu Oshima, Masahiro Aoki, Makoto Mark Taketo Hiroyuki Miyoshi, Atsuko Deguchi, Masayuki Nakau, Yasushi Kojima, Akira Mori, Masanobu Oshima, Masahiro Aoki, Makoto Mark Taketo Hiroyuki Miyoshi, Atsuko Deguchi, Masayuki Nakau, Yasushi Kojima, Akira Mori, Masanobu Oshima, Masahiro Aoki, Makoto Mark Taketo Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice CANCER SCIENCE, 100, 11, 2046-2053 CANCER SCIENCE, 100, 11, 2046-2053 CANCER SCIENCE, 100, 11, 2046-2053 2009/11 英語 研究論文(学術雑誌) 公開
Thaddeus S. Stappenbeck, Hiroyuki Miyoshi Thaddeus S. Stappenbeck, Hiroyuki Miyoshi Thaddeus S. Stappenbeck, Hiroyuki Miyoshi The Role of Stromal Stem Cells in Tissue Regeneration and Wound Repair The Role of Stromal Stem Cells in Tissue Regeneration and Wound Repair The Role of Stromal Stem Cells in Tissue Regeneration and Wound Repair SCIENCE, 324, 5935, 1666-1669 SCIENCE, 324, 5935, 1666-1669 SCIENCE, 324, 5935, 1666-1669 2009/06 英語 公開
Hiroshi Seno, Hiroyuki Miyoshi, Sarah L. Brown, Michael J. Geske, Marco Colonna, Thaddeus S. Stappenbeck Hiroshi Seno, Hiroyuki Miyoshi, Sarah L. Brown, Michael J. Geske, Marco Colonna, Thaddeus S. Stappenbeck Hiroshi Seno, Hiroyuki Miyoshi, Sarah L. Brown, Michael J. Geske, Marco Colonna, Thaddeus S. Stappenbeck Efficient colonic mucosal wound repair requires Trem2 signaling Efficient colonic mucosal wound repair requires Trem2 signaling Efficient colonic mucosal wound repair requires Trem2 signaling PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106, 1, 256-261 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106, 1, 256-261 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106, 1, 256-261 2009/01 英語 研究論文(学術雑誌) 公開
Ken Cadwell, John Y. Liu, Sarah L. Brown, Hiroyuki Miyoshi, Joy Loh, Jochen K. Lennerz, Chieko Kishi, Wumesh Kc, Javier A. Carrero, Steven Hunt, Christian D. Stone, Elizabeth M. Brunt, Ramnik J. Xavier, Barry P. Sleckman, Ellen Li, Noboru Mizushima, Thaddeus S. Stappenbeck, Herbert W. Virgin Ken Cadwell, John Y. Liu, Sarah L. Brown, Hiroyuki Miyoshi, Joy Loh, Jochen K. Lennerz, Chieko Kishi, Wumesh Kc, Javier A. Carrero, Steven Hunt, Christian D. Stone, Elizabeth M. Brunt, Ramnik J. Xavier, Barry P. Sleckman, Ellen Li, Noboru Mizushima, Thaddeus S. Stappenbeck, Herbert W. Virgin Ken Cadwell, John Y. Liu, Sarah L. Brown, Hiroyuki Miyoshi, Joy Loh, Jochen K. Lennerz, Chieko Kishi, Wumesh Kc, Javier A. Carrero, Steven Hunt, Christian D. Stone, Elizabeth M. Brunt, Ramnik J. Xavier, Barry P. Sleckman, Ellen Li, Noboru Mizushima, Thaddeus S. Stappenbeck, Herbert W. Virgin A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells NATURE, 456, 7219, 259-U62 NATURE, 456, 7219, 259-U62 NATURE, 456, 7219, 259-U62 2008/11 英語 研究論文(学術雑誌) 公開
Nigel Turner, Jing-Ya Li, Alison Gosby, Sabrina W. C. To, Zhe Cheng, Hiroyuki Miyoshi, Makoto M. Taketo, Gregory J. Cooney, Edward W. Kraegen, David E. James, Li-Hong Hu, Jia Li, Ji-Ming Ye Nigel Turner, Jing-Ya Li, Alison Gosby, Sabrina W. C. To, Zhe Cheng, Hiroyuki Miyoshi, Makoto M. Taketo, Gregory J. Cooney, Edward W. Kraegen, David E. James, Li-Hong Hu, Jia Li, Ji-Ming Ye Nigel Turner, Jing-Ya Li, Alison Gosby, Sabrina W. C. To, Zhe Cheng, Hiroyuki Miyoshi, Makoto M. Taketo, Gregory J. Cooney, Edward W. Kraegen, David E. James, Li-Hong Hu, Jia Li, Ji-Ming Ye Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-Activated protein kinase and improve insulin action Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-Activated protein kinase and improve insulin action Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-Activated protein kinase and improve insulin action DIABETES, 57, 5, 1414-1418 DIABETES, 57, 5, 1414-1418 DIABETES, 57, 5, 1414-1418 2008/05 英語 研究論文(学術雑誌) 公開
Yasushi Kojima, Hiroyuki Miyoshi, Hans C. Clevers, Masanobu Oshima, Masahiro Aoki, Makoto M. Taketo Yasushi Kojima, Hiroyuki Miyoshi, Hans C. Clevers, Masanobu Oshima, Masahiro Aoki, Makoto M. Taketo Yasushi Kojima, Hiroyuki Miyoshi, Hans C. Clevers, Masanobu Oshima, Masahiro Aoki, Makoto M. Taketo Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling JOURNAL OF BIOLOGICAL CHEMISTRY, 282, 32, 23532-23540 JOURNAL OF BIOLOGICAL CHEMISTRY, 282, 32, 23532-23540 JOURNAL OF BIOLOGICAL CHEMISTRY, 282, 32, 23532-23540 2007/08 英語 研究論文(学術雑誌) 公開
K. Aoki, M. Aoki, M. Sugai, N. Harada, H. Miyoshi, T. Tsukamoto, T. Mizoshita, M. Tatematsu, H. Seno, T. Chiba, M. Oshima, C-L Hsieh, M. M. Taketo K. Aoki, M. Aoki, M. Sugai, N. Harada, H. Miyoshi, T. Tsukamoto, T. Mizoshita, M. Tatematsu, H. Seno, T. Chiba, M. Oshima, C-L Hsieh, M. M. Taketo K. Aoki, M. Aoki, M. Sugai, N. Harada, H. Miyoshi, T. Tsukamoto, T. Mizoshita, M. Tatematsu, H. Seno, T. Chiba, M. Oshima, C-L Hsieh, M. M. Taketo Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells ONCOGENE, 26, 24, 3511-3520 ONCOGENE, 26, 24, 3511-3520 ONCOGENE, 26, 24, 3511-3520 2007/05 英語 研究論文(学術雑誌) 公開
Takanori Kitamura, Kohei Kometani, Hiroki Hashida, Akihiro Matsunaga, Hiroyuki Miyoshi, Hisahiro Hosogi, Masahiro Aoki, Masanobu Oshima, Masakazu Hattori, Arimichi Takabayashi, Nagahiro Minato, Makoto M. Taketo Takanori Kitamura, Kohei Kometani, Hiroki Hashida, Akihiro Matsunaga, Hiroyuki Miyoshi, Hisahiro Hosogi, Masahiro Aoki, Masanobu Oshima, Masakazu Hattori, Arimichi Takabayashi, Nagahiro Minato, Makoto M. Taketo Takanori Kitamura, Kohei Kometani, Hiroki Hashida, Akihiro Matsunaga, Hiroyuki Miyoshi, Hisahiro Hosogi, Masahiro Aoki, Masanobu Oshima, Masakazu Hattori, Arimichi Takabayashi, Nagahiro Minato, Makoto M. Taketo SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion NATURE GENETICS, 39, 4, 467-475 NATURE GENETICS, 39, 4, 467-475 NATURE GENETICS, 39, 4, 467-475 2007/04 英語 研究論文(学術雑誌) 公開
Takaharu Maruyama, Kenichi Tanaka, Jun Suzuki, Hiroyuki Miyoshi, Naomoto Harada, Takao Nakamura, Yasuhisa Miyamoto, Akio Kanatani, Yoshitaka Tamai Takaharu Maruyama, Kenichi Tanaka, Jun Suzuki, Hiroyuki Miyoshi, Naomoto Harada, Takao Nakamura, Yasuhisa Miyamoto, Akio Kanatani, Yoshitaka Tamai Takaharu Maruyama, Kenichi Tanaka, Jun Suzuki, Hiroyuki Miyoshi, Naomoto Harada, Takao Nakamura, Yasuhisa Miyamoto, Akio Kanatani, Yoshitaka Tamai Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice JOURNAL OF ENDOCRINOLOGY, 191, 1, 197-205 JOURNAL OF ENDOCRINOLOGY, 191, 1, 197-205 JOURNAL OF ENDOCRINOLOGY, 191, 1, 197-205 2006/10 英語 研究論文(学術雑誌) 公開
H Takeda, H Miyoshi, Y Kojima, M Oshima, MM Taketo H Takeda, H Miyoshi, Y Kojima, M Oshima, MM Taketo H Takeda, H Miyoshi, Y Kojima, M Oshima, MM Taketo Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1(+/-)p53(-/-) compound mutant mice Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1(+/-)p53(-/-) compound mutant mice Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1(+/-)p53(-/-) compound mutant mice ONCOGENE, 25, 12, 1816-1820 ONCOGENE, 25, 12, 1816-1820 ONCOGENE, 25, 12, 1816-1820 2006/03 英語 研究論文(学術雑誌) 公開
Q Li, T Ishikawa, H Miyoshi, M Oshima, MM Taketo Q Li, T Ishikawa, H Miyoshi, M Oshima, MM Taketo Q Li, T Ishikawa, H Miyoshi, M Oshima, MM Taketo A targeted mutation of Nkd1 impairs mouse spermatogenesis A targeted mutation of Nkd1 impairs mouse spermatogenesis A targeted mutation of Nkd1 impairs mouse spermatogenesis JOURNAL OF BIOLOGICAL CHEMISTRY, 280, 4, 2831-2839 JOURNAL OF BIOLOGICAL CHEMISTRY, 280, 4, 2831-2839 JOURNAL OF BIOLOGICAL CHEMISTRY, 280, 4, 2831-2839 2005/01 英語 研究論文(学術雑誌) 公開
H Takeda, H Miyoshi, Y Tamai, M Oshima, MM Taketo H Takeda, H Miyoshi, Y Tamai, M Oshima, MM Taketo H Takeda, H Miyoshi, Y Tamai, M Oshima, MM Taketo Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas BRITISH JOURNAL OF CANCER, 90, 3, 701-704 BRITISH JOURNAL OF CANCER, 90, 3, 701-704 BRITISH JOURNAL OF CANCER, 90, 3, 701-704 2004/02 英語 研究論文(学術雑誌) 公開
S Okano, A Asano, Y Kon, H Miyoshi, T Watanabe S Okano, A Asano, Y Kon, H Miyoshi, T Watanabe S Okano, A Asano, Y Kon, H Miyoshi, T Watanabe Genetic analysis of jumbled spine and ribs (Jsr) mutation affecting the vertebral development in mice Genetic analysis of jumbled spine and ribs (Jsr) mutation affecting the vertebral development in mice Genetic analysis of jumbled spine and ribs (Jsr) mutation affecting the vertebral development in mice BIOCHEMICAL GENETICS, 40, 9-10, 311-322 BIOCHEMICAL GENETICS, 40, 9-10, 311-322 BIOCHEMICAL GENETICS, 40, 9-10, 311-322 2002/10 英語 研究論文(学術雑誌) 公開
M Nakau, H Miyoshi, MF Seldin, M Imamura, M Oshima, MM Taketo M Nakau, H Miyoshi, MF Seldin, M Imamura, M Oshima, MM Taketo M Nakau, H Miyoshi, MF Seldin, M Imamura, M Oshima, MM Taketo Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice CANCER RESEARCH, 62, 16, 4549-4553 CANCER RESEARCH, 62, 16, 4549-4553 CANCER RESEARCH, 62, 16, 4549-4553 2002/08 英語 研究論文(学術雑誌) 公開
N Harada, H Miyoshi, N Murai, H Oshima, Y Tamai, M Oshima, MM Taketo N Harada, H Miyoshi, N Murai, H Oshima, Y Tamai, M Oshima, MM Taketo N Harada, H Miyoshi, N Murai, H Oshima, Y Tamai, M Oshima, MM Taketo Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin CANCER RESEARCH, 62, 7, 1971-1977 CANCER RESEARCH, 62, 7, 1971-1977 CANCER RESEARCH, 62, 7, 1971-1977 2002/04 英語 研究論文(学術雑誌) 公開
H Miyoshi, M Nakau, T Ishikawa, MF Seldin, M Oshima, MM Taketo H Miyoshi, M Nakau, T Ishikawa, MF Seldin, M Oshima, MM Taketo H Miyoshi, M Nakau, T Ishikawa, MF Seldin, M Oshima, MM Taketo Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice CANCER RESEARCH, 62, 8, 2261-2266 CANCER RESEARCH, 62, 8, 2261-2266 CANCER RESEARCH, 62, 8, 2261-2266 2002/04 英語 研究論文(学術雑誌) 公開
K Takaku, H Miyoshi, A Matsunaga, M Oshima, N Sasaki, MM Taketo K Takaku, H Miyoshi, A Matsunaga, M Oshima, N Sasaki, MM Taketo K Takaku, H Miyoshi, A Matsunaga, M Oshima, N Sasaki, MM Taketo Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice CANCER RESEARCH, 59, 24, 6113-6117 CANCER RESEARCH, 59, 24, 6113-6117 CANCER RESEARCH, 59, 24, 6113-6117 1999/12 英語 研究論文(学術雑誌) 公開
H Miyoshi, Y Kon, KW Seo, HK Jin, A Hasegawa, T Watanabe H Miyoshi, Y Kon, KW Seo, HK Jin, A Hasegawa, T Watanabe H Miyoshi, Y Kon, KW Seo, HK Jin, A Hasegawa, T Watanabe Jumbled spine and ribs (Jsr): a new mutation on mouse Chromosome 5 Jumbled spine and ribs (Jsr): a new mutation on mouse Chromosome 5 Jumbled spine and ribs (Jsr): a new mutation on mouse Chromosome 5 MAMMALIAN GENOME, 10, 3, 213-217 MAMMALIAN GENOME, 10, 3, 213-217 MAMMALIAN GENOME, 10, 3, 213-217 1999/03 英語 研究論文(学術雑誌) 公開
K Takaku, M Oshima, H Miyoshi, M Matsui, MF Seldin, MM Taketo K Takaku, M Oshima, H Miyoshi, M Matsui, MF Seldin, MM Taketo K Takaku, M Oshima, H Miyoshi, M Matsui, MF Seldin, MM Taketo Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes CELL, 92, 5, 645-656 CELL, 92, 5, 645-656 CELL, 92, 5, 645-656 1998/03 英語 研究論文(学術雑誌) 公開
KW Seo, H Miyoshi, Y Kon, T Watanabe KW Seo, H Miyoshi, Y Kon, T Watanabe KW Seo, H Miyoshi, Y Kon, T Watanabe Chromosomal mapping and developmental study of tattered-Hokkaido (Td(ho)) Chromosomal mapping and developmental study of tattered-Hokkaido (Td(ho)) Chromosomal mapping and developmental study of tattered-Hokkaido (Td(ho)) MAMMALIAN GENOME, 8, 8, 578-580 MAMMALIAN GENOME, 8, 8, 578-580 MAMMALIAN GENOME, 8, 8, 578-580 1997/08 英語 研究論文(学術雑誌) 公開

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著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Hiroyuki Miyoshi, Kelli VanDussen, Nicole Malvin, Stacy Ryu, Yi Wang, Naomi Sonnek, Chin-Wen Lai, Thaddeus Stappenbeck Hiroyuki Miyoshi, Kelli VanDussen, Nicole Malvin, Stacy Ryu, Yi Wang, Naomi Sonnek, Chin-Wen Lai, Thaddeus Stappenbeck Hiroyuki Miyoshi, Kelli VanDussen, Nicole Malvin, Stacy Ryu, Yi Wang, Naomi Sonnek, Chin-Wen Lai, Thaddeus Stappenbeck Prostaglandin E2 Promotes Intestinal Repair Through an Adaptive Cellular Response of the Epithelium Prostaglandin E2 Promotes Intestinal Repair Through an Adaptive Cellular Response of the Epithelium Prostaglandin E2 Promotes Intestinal Repair Through an Adaptive Cellular Response of the Epithelium INFLAMMATORY BOWEL DISEASES, 23, S93-S93 INFLAMMATORY BOWEL DISEASES, 23, S93-S93 INFLAMMATORY BOWEL DISEASES, 23, S93-S93 2017/02 英語 研究発表要旨(国際会議) 公開
Thomas J. Hannan, Pacita L. Roberts, Terrence E. Riehl, Sjoerd van der Post, Jana M. Binkley, Drew J. Schwartz, Hiroyuki Miyoshi, Matthias Mack, Reto A. Schwendener, Thomas M. Hooton, Thaddeus S. Stappenbeck, Gunnar C. Hansson, William F. Stenson, Marco Colonna, Ann E. Stapleton, Scott J. Hultgren Thomas J. Hannan, Pacita L. Roberts, Terrence E. Riehl, Sjoerd van der Post, Jana M. Binkley, Drew J. Schwartz, Hiroyuki Miyoshi, Matthias Mack, Reto A. Schwendener, Thomas M. Hooton, Thaddeus S. Stappenbeck, Gunnar C. Hansson, William F. Stenson, Marco Colonna, Ann E. Stapleton, Scott J. Hultgren Thomas J. Hannan, Pacita L. Roberts, Terrence E. Riehl, Sjoerd van der Post, Jana M. Binkley, Drew J. Schwartz, Hiroyuki Miyoshi, Matthias Mack, Reto A. Schwendener, Thomas M. Hooton, Thaddeus S. Stappenbeck, Gunnar C. Hansson, William F. Stenson, Marco Colonna, Ann E. Stapleton, Scott J. Hultgren Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis JOURNAL OF WOMENS HEALTH, 23, 10, 875-876 JOURNAL OF WOMENS HEALTH, 23, 10, 875-876 JOURNAL OF WOMENS HEALTH, 23, 10, 875-876 2014/10 英語 研究発表要旨(国際会議) 公開
Kelli L. VanDussen, Jeffrey M. Marinshaw, Hiroyuki Miyoshi, Matthew A. Ciorba, Thaddeus S. Stappenbeck Kelli L. VanDussen, Jeffrey M. Marinshaw, Hiroyuki Miyoshi, Matthew A. Ciorba, Thaddeus S. Stappenbeck Kelli L. VanDussen, Jeffrey M. Marinshaw, Hiroyuki Miyoshi, Matthew A. Ciorba, Thaddeus S. Stappenbeck Efficient Isolation, Expansion and Differentiation of Human Epithelial Stem Cells From Endoscopic Biopsies of the Gastrointestinal Tract Efficient Isolation, Expansion and Differentiation of Human Epithelial Stem Cells From Endoscopic Biopsies of the Gastrointestinal Tract Efficient Isolation, Expansion and Differentiation of Human Epithelial Stem Cells From Endoscopic Biopsies of the Gastrointestinal Tract GASTROENTEROLOGY, 144, 5, S62-S63 GASTROENTEROLOGY, 144, 5, S62-S63 GASTROENTEROLOGY, 144, 5, S62-S63 2013/05 英語 研究発表要旨(国際会議) 公開
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外部資金:競争的資金 (科学研究費補助金)
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
基盤研究(B) 代表 成体上皮細胞の組織アイデンティティを特定するエピジェネティック修飾の解明 (平成30年度分) 2018/04/01〜2019/03/31
基盤研究(B) 代表 成体上皮細胞の組織アイデンティティを特定するエピジェネティック修飾の解明 (2019年度分) 2019/04/01〜2020/03/31