三好 弘之

最終更新日時: 2019/10/11 08:28:28

印刷する

氏名(漢字/フリガナ/アルファベット表記)
三好 弘之/ミヨシ ヒロユキ/
所属部署・職名(部局/所属/講座等/職名)
医学部附属病院/臨床研究総合センター/准教授
所属学会(国内)
学会名(日本語) 学会名(英語)
日本癌学会 Japanese Cancer Association
日本分子生物学会 The Molecular Biology Society of Japan
所属学会(海外)
学会名(英語) 国名
American Association for Cancer Research USA
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
博士(医学) 京都大学
出身学校・専攻等
大学名(日本語) 大学名(英語) 学部名(日本語) 学部名(英語) 学科名(日本語) 学科名(英語) 卒業区分
北海道大学 獣医学部獣医学科 卒業
職歴
期間 組織名(日本語) 組織名(英語) 職名(日本語) 職名(英語)
2002/10/01〜2008/03/31 京都大学医学研究科 Kyoto University Graduate School of Medicine 助手/助教 Assistant Professor
2008/04/01〜2012/12/31 ワシントン大学医学部病理免疫部門 Department of Pathology & Immunology, Washington University School of Medicine 博士研究員 Postdoctoral Research Associate
2013/01/01〜2014/10/31 ワシントン大学医学部病理免疫部門 Department of Pathology & Immunology, Washington University School of Medicine インストラクター Instructor
2014/11/01〜2016/12/31 京都大学医学部附属病院 Kyoto University Hospital 特定准教授 Associate Professor
2017/01/01〜2019/09/30 京都大学産官学連携本部 Kyoto University Office of Society-Academia Collaboration for Innovation 特任准教授 Associate Professor
2019/10/01〜 京都大学医学部附属病院 臨床研究総合センター Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital 准教授 Associate professor
ORCID ID
https://orcid.org/0000-0001-7400-0714
researchmap URL
https://researchmap.jp/7000011426
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Goto N, Fukuda A, Yamaga Y, Yoshikawa T, Maruno T, Maekawa H, Inamoto S, Kawada K, Sakai Y, Miyoshi H, Taketo MM, Chiba T, Seno H Goto N, Fukuda A, Yamaga Y, Yoshikawa T, Maruno T, Maekawa H, Inamoto S, Kawada K, Sakai Y, Miyoshi H, Taketo MM, Chiba T, Seno H Goto N, Fukuda A, Yamaga Y, Yoshikawa T, Maruno T, Maekawa H, Inamoto S, Kawada K, Sakai Y, Miyoshi H, Taketo MM, Chiba T, Seno H Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences 2019/06 公開
Hiramatsu Y, Fukuda A, Ogawa S, Goto N, Ikuta K, Tsuda M, Matsumoto Y, Kimura Y, Yoshioka T, Takada Y, Maruno T, Hanyu Y, Tsuruyama T, Wang Z, Akiyama H, Takaishi S, Miyoshi H, Taketo MM, Chiba T, Seno H Hiramatsu Y, Fukuda A, Ogawa S, Goto N, Ikuta K, Tsuda M, Matsumoto Y, Kimura Y, Yoshioka T, Takada Y, Maruno T, Hanyu Y, Tsuruyama T, Wang Z, Akiyama H, Takaishi S, Miyoshi H, Taketo MM, Chiba T, Seno H Hiramatsu Y, Fukuda A, Ogawa S, Goto N, Ikuta K, Tsuda M, Matsumoto Y, Kimura Y, Yoshioka T, Takada Y, Maruno T, Hanyu Y, Tsuruyama T, Wang Z, Akiyama H, Takaishi S, Miyoshi H, Taketo MM, Chiba T, Seno H Arid1a is essential for intestinal stem cells through Sox9 regulation Arid1a is essential for intestinal stem cells through Sox9 regulation Arid1a is essential for intestinal stem cells through Sox9 regulation Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences 2019/01 公開
Yamaura T, Miyoshi H, Maekawa H, Morimoto T, Yamamoto T, Kakizaki F, Higasa K, Kawada K, Matsuda F, Sakai Y, Taketo MM Yamaura T, Miyoshi H, Maekawa H, Morimoto T, Yamamoto T, Kakizaki F, Higasa K, Kawada K, Matsuda F, Sakai Y, Taketo MM Yamaura T, Miyoshi H, Maekawa H, Morimoto T, Yamamoto T, Kakizaki F, Higasa K, Kawada K, Matsuda F, Sakai Y, Taketo MM Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells Oncotarget, 9, 101, 37534-37548 Oncotarget, 9, 101, 37534-37548 Oncotarget, 9, 101, 37534-37548 2018/12 英語 研究論文(学術雑誌) 公開
Maekawa H, Miyoshi H, Yamaura T, Itatani Y, Kawada K, Sakai Y, Taketo MM Maekawa H, Miyoshi H, Yamaura T, Itatani Y, Kawada K, Sakai Y, Taketo MM Maekawa H, Miyoshi H, Yamaura T, Itatani Y, Kawada K, Sakai Y, Taketo MM A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor Initiating Cells A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor Initiating Cells A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor Initiating Cells Mol Cancer Ther. Mol Cancer Ther. Mol Cancer Ther. 2018/07 英語 研究論文(学術雑誌) 公開
Aoyama N, Miyoshi H, Miyachi H, Sonoshita M, Okabe M, Taketo MM Aoyama N, Miyoshi H, Miyachi H, Sonoshita M, Okabe M, Taketo MM Aoyama N, Miyoshi H, Miyachi H, Sonoshita M, Okabe M, Taketo MM Transgenic mice that accept Luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies Transgenic mice that accept Luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies Transgenic mice that accept Luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies Genes to Cells Genes to Cells Genes to Cells 2018/05 英語 研究論文(学術雑誌) 公開
Miyoshi H, Maekawa H, Kakizaki F, Yamaura T, Kawada K, Sakai Y, Taketo MM Miyoshi H, Maekawa H, Kakizaki F, Yamaura T, Kawada K, Sakai Y, Taketo MM Miyoshi H, Maekawa H, Kakizaki F, Yamaura T, Kawada K, Sakai Y, Taketo MM An improved method for culturing patient-derived colorectal cancer spheroids An improved method for culturing patient-derived colorectal cancer spheroids An improved method for culturing patient-derived colorectal cancer spheroids Oncotarget, 9, 31, 21950-21964 Oncotarget, 9, 31, 21950-21964 Oncotarget, 9, 31, 21950-21964 2018/04 英語 研究論文(学術雑誌) 公開
Goto N, Ueo T, Fukuda A, Kawada K, Sakai Y, Miyoshi H, Taketo MM, Chiba T, Seno H Goto N, Ueo T, Fukuda A, Kawada K, Sakai Y, Miyoshi H, Taketo MM, Chiba T, Seno H Goto N, Ueo T, Fukuda A, Kawada K, Sakai Y, Miyoshi H, Taketo MM, Chiba T, Seno H Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine. Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine. Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine. Cancer research Cancer research Cancer research 2017/05 公開
Miyoshi H Miyoshi H Miyoshi H Wnt-expressing cells in the intestines: guides for tissue remodeling. Wnt-expressing cells in the intestines: guides for tissue remodeling. Wnt-expressing cells in the intestines: guides for tissue remodeling. Journal of biochemistry, 161, 1, 19-25 Journal of biochemistry, 161, 1, 19-25 Journal of biochemistry, 161, 1, 19-25 2017/01 公開
Miyoshi H, VanDussen KL, Malvin NP, Ryu SH, Wang Y, Sonnek NM, Lai CW, Stappenbeck TS Miyoshi H, VanDussen KL, Malvin NP, Ryu SH, Wang Y, Sonnek NM, Lai CW, Stappenbeck TS Miyoshi H, VanDussen KL, Malvin NP, Ryu SH, Wang Y, Sonnek NM, Lai CW, Stappenbeck TS Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. The EMBO journal, 36, 1, 5-24 The EMBO journal, 36, 1, 5-24 The EMBO journal, 36, 1, 5-24 2017/01 公開
Kakizaki F, Sonoshita M, Miyoshi H, Itatani Y, Ito S, Kawada K, Sakai Y, Taketo MM Kakizaki F, Sonoshita M, Miyoshi H, Itatani Y, Ito S, Kawada K, Sakai Y, Taketo MM Kakizaki F, Sonoshita M, Miyoshi H, Itatani Y, Ito S, Kawada K, Sakai Y, Taketo MM Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2. Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2. Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2. Cancer science, 107, 11, 1622-1631 Cancer science, 107, 11, 1622-1631 Cancer science, 107, 11, 1622-1631 2016/11 公開
Okuchi Y, Imajo M, Mizuno R, Kamioka Y, Miyoshi H, Taketo MM, Nagayama S, Sakai Y, Matsuda M Okuchi Y, Imajo M, Mizuno R, Kamioka Y, Miyoshi H, Taketo MM, Nagayama S, Sakai Y, Matsuda M Okuchi Y, Imajo M, Mizuno R, Kamioka Y, Miyoshi H, Taketo MM, Nagayama S, Sakai Y, Matsuda M Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis. Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis. Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis. PloS one, 11, 9, e0162300 PloS one, 11, 9, e0162300 PloS one, 11, 9, e0162300 2016/09 公開
Uchiyama K, Sakiyama T, Hasebe T, Musch MW, Miyoshi H, Nakagawa Y, He TC, Lichtenstein L, Naito Y, Itoh Y, Yoshikawa T, Jabri B, Stappenbeck T, Chang EB Uchiyama K, Sakiyama T, Hasebe T, Musch MW, Miyoshi H, Nakagawa Y, He TC, Lichtenstein L, Naito Y, Itoh Y, Yoshikawa T, Jabri B, Stappenbeck T, Chang EB Uchiyama K, Sakiyama T, Hasebe T, Musch MW, Miyoshi H, Nakagawa Y, He TC, Lichtenstein L, Naito Y, Itoh Y, Yoshikawa T, Jabri B, Stappenbeck T, Chang EB Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development. Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development. Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development. Scientific reports, 6, 32094 Scientific reports, 6, 32094 Scientific reports, 6, 32094 2016/08 公開
VanDussen KL, Marinshaw JM, Shaikh N, Miyoshi H, Moon C, Tarr PI, Ciorba MA, Stappenbeck TS VanDussen KL, Marinshaw JM, Shaikh N, Miyoshi H, Moon C, Tarr PI, Ciorba MA, Stappenbeck TS VanDussen KL, Marinshaw JM, Shaikh N, Miyoshi H, Moon C, Tarr PI, Ciorba MA, Stappenbeck TS Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays. Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays. Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays. Gut, 64, 6, 911-920 Gut, 64, 6, 911-920 Gut, 64, 6, 911-920 2015/06 公開
Sun L, Miyoshi H, Origanti S, Nice TJ, Barger AC, Manieri NA, Fogel LA, French AR, Piwnica-Worms D, Piwnica-Worms H, Virgin HW, Lenschow DJ, Stappenbeck TS Sun L, Miyoshi H, Origanti S, Nice TJ, Barger AC, Manieri NA, Fogel LA, French AR, Piwnica-Worms D, Piwnica-Worms H, Virgin HW, Lenschow DJ, Stappenbeck TS Sun L, Miyoshi H, Origanti S, Nice TJ, Barger AC, Manieri NA, Fogel LA, French AR, Piwnica-Worms D, Piwnica-Worms H, Virgin HW, Lenschow DJ, Stappenbeck TS Type I interferons link viral infection to enhanced epithelial turnover and repair. Type I interferons link viral infection to enhanced epithelial turnover and repair. Type I interferons link viral infection to enhanced epithelial turnover and repair. Cell host & microbe, 17, 1, 85-97 Cell host & microbe, 17, 1, 85-97 Cell host & microbe, 17, 1, 85-97 2015/01 公開
Hannan TJ, Roberts PL, Riehl TE, van der Post S, Binkley JM, Schwartz DJ, Miyoshi H, Mack M, Schwendener RA, Hooton TM, Stappenbeck TS, Hansson GC, Stenson WF, Colonna M, Stapleton AE, Hultgren SJ Hannan TJ, Roberts PL, Riehl TE, van der Post S, Binkley JM, Schwartz DJ, Miyoshi H, Mack M, Schwendener RA, Hooton TM, Stappenbeck TS, Hansson GC, Stenson WF, Colonna M, Stapleton AE, Hultgren SJ Hannan TJ, Roberts PL, Riehl TE, van der Post S, Binkley JM, Schwartz DJ, Miyoshi H, Mack M, Schwendener RA, Hooton TM, Stappenbeck TS, Hansson GC, Stenson WF, Colonna M, Stapleton AE, Hultgren SJ Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis. Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis. Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis. EBioMedicine, 1, 1, 46-57 EBioMedicine, 1, 1, 46-57 EBioMedicine, 1, 1, 46-57 2014/10 公開
Moon C, VanDussen KL, Miyoshi H, Stappenbeck TS Moon C, VanDussen KL, Miyoshi H, Stappenbeck TS Moon C, VanDussen KL, Miyoshi H, Stappenbeck TS Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis. Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis. Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis. Mucosal immunology, 7, 4, 818-828 Mucosal immunology, 7, 4, 818-828 Mucosal immunology, 7, 4, 818-828 2014/07 公開
Miyoshi H, Stappenbeck TS Miyoshi H, Stappenbeck TS Miyoshi H, Stappenbeck TS The young and the Wnt-less: transplantable fetal intestinal spheroids without Wnts. The young and the Wnt-less: transplantable fetal intestinal spheroids without Wnts. The young and the Wnt-less: transplantable fetal intestinal spheroids without Wnts. Cell stem cell, 13, 6, 637-638 Cell stem cell, 13, 6, 637-638 Cell stem cell, 13, 6, 637-638 2013/12 公開
Miyoshi H, Stappenbeck TS Miyoshi H, Stappenbeck TS Miyoshi H, Stappenbeck TS In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture. In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture. In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture. Nature protocols, 8, 12, 2471-2482 Nature protocols, 8, 12, 2471-2482 Nature protocols, 8, 12, 2471-2482 2013/12 公開
Patel KK, Miyoshi H, Beatty WL, Head RD, Malvin NP, Cadwell K, Guan JL, Saitoh T, Akira S, Seglen PO, Dinauer MC, Virgin HW, Stappenbeck TS Patel KK, Miyoshi H, Beatty WL, Head RD, Malvin NP, Cadwell K, Guan JL, Saitoh T, Akira S, Seglen PO, Dinauer MC, Virgin HW, Stappenbeck TS Patel KK, Miyoshi H, Beatty WL, Head RD, Malvin NP, Cadwell K, Guan JL, Saitoh T, Akira S, Seglen PO, Dinauer MC, Virgin HW, Stappenbeck TS Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. The EMBO journal, 32, 24, 3130-3144 The EMBO journal, 32, 24, 3130-3144 The EMBO journal, 32, 24, 3130-3144 2013/12 公開
Miyoshi H, Stappenbeck TS Miyoshi H, Stappenbeck TS Miyoshi H, Stappenbeck TS Counteracting stem cell expansion during wound repair: distinct roles of non-canonical Wnt and TGF-β. Counteracting stem cell expansion during wound repair: distinct roles of non-canonical Wnt and TGF-β. Counteracting stem cell expansion during wound repair: distinct roles of non-canonical Wnt and TGF-β. Cell cycle (Georgetown, Tex.), 12, 3, 387-388 Cell cycle (Georgetown, Tex.), 12, 3, 387-388 Cell cycle (Georgetown, Tex.), 12, 3, 387-388 2013/02 公開
Aly H, Rohatgi N, Marshall CA, Grossenheider TC, Miyoshi H, Stappenbeck TS, Matkovich SJ, McDaniel ML Aly H, Rohatgi N, Marshall CA, Grossenheider TC, Miyoshi H, Stappenbeck TS, Matkovich SJ, McDaniel ML Aly H, Rohatgi N, Marshall CA, Grossenheider TC, Miyoshi H, Stappenbeck TS, Matkovich SJ, McDaniel ML A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype. A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype. A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype. PloS one, 8, 6, e66131 PloS one, 8, 6, e66131 PloS one, 8, 6, e66131 2013 公開
Miyoshi H, Ajima R, Luo CT, Yamaguchi TP, Stappenbeck TS Miyoshi H, Ajima R, Luo CT, Yamaguchi TP, Stappenbeck TS Miyoshi H, Ajima R, Luo CT, Yamaguchi TP, Stappenbeck TS Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury. Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury. Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury. Science (New York, N.Y.), 338, 6103, 108-113 Science (New York, N.Y.), 338, 6103, 108-113 Science (New York, N.Y.), 338, 6103, 108-113 2012/10 公開
Manieri NA, Drylewicz MR, Miyoshi H, Stappenbeck TS Manieri NA, Drylewicz MR, Miyoshi H, Stappenbeck TS Manieri NA, Drylewicz MR, Miyoshi H, Stappenbeck TS Igf2bp1 is required for full induction of Ptgs2 mRNA in colonic mesenchymal stem cells in mice. Igf2bp1 is required for full induction of Ptgs2 mRNA in colonic mesenchymal stem cells in mice. Igf2bp1 is required for full induction of Ptgs2 mRNA in colonic mesenchymal stem cells in mice. Gastroenterology, 143, 1, 110-21.e10 Gastroenterology, 143, 1, 110-21.e10 Gastroenterology, 143, 1, 110-21.e10 2012/07 公開
Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell, 147, 5, 1146-1158 Cell, 147, 5, 1146-1158 Cell, 147, 5, 1146-1158 2011/11 公開
Deguchi A, Miyoshi H, Kojima Y, Okawa K, Aoki M, Taketo MM Deguchi A, Miyoshi H, Kojima Y, Okawa K, Aoki M, Taketo MM Deguchi A, Miyoshi H, Kojima Y, Okawa K, Aoki M, Taketo MM LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain. LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain. LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain. The Journal of biological chemistry, 285, 24, 18283-18290 The Journal of biological chemistry, 285, 24, 18283-18290 The Journal of biological chemistry, 285, 24, 18283-18290 2010/06 公開
Kakizaki F, Aoki K, Miyoshi H, Carrasco N, Aoki M, Taketo MM Kakizaki F, Aoki K, Miyoshi H, Carrasco N, Aoki M, Taketo MM Kakizaki F, Aoki K, Miyoshi H, Carrasco N, Aoki M, Taketo MM CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium. CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium. CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium. Gastroenterology, 138, 2, 627-635 Gastroenterology, 138, 2, 627-635 Gastroenterology, 138, 2, 627-635 2010/02 公開
Miyoshi H, Deguchi A, Nakau M, Kojima Y, Mori A, Oshima M, Aoki M, Taketo MM Miyoshi H, Deguchi A, Nakau M, Kojima Y, Mori A, Oshima M, Aoki M, Taketo MM Miyoshi H, Deguchi A, Nakau M, Kojima Y, Mori A, Oshima M, Aoki M, Taketo MM Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice. Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice. Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice. Cancer science, 100, 11, 2046-2053 Cancer science, 100, 11, 2046-2053 Cancer science, 100, 11, 2046-2053 2009/11 公開
Stappenbeck TS, Miyoshi H Stappenbeck TS, Miyoshi H Stappenbeck TS, Miyoshi H The role of stromal stem cells in tissue regeneration and wound repair. The role of stromal stem cells in tissue regeneration and wound repair. The role of stromal stem cells in tissue regeneration and wound repair. Science (New York, N.Y.), 324, 5935, 1666-1669 Science (New York, N.Y.), 324, 5935, 1666-1669 Science (New York, N.Y.), 324, 5935, 1666-1669 2009/06 公開
Seno H, Miyoshi H, Brown SL, Geske MJ, Colonna M, Stappenbeck TS Seno H, Miyoshi H, Brown SL, Geske MJ, Colonna M, Stappenbeck TS Seno H, Miyoshi H, Brown SL, Geske MJ, Colonna M, Stappenbeck TS Efficient colonic mucosal wound repair requires Trem2 signaling. Efficient colonic mucosal wound repair requires Trem2 signaling. Efficient colonic mucosal wound repair requires Trem2 signaling. Proceedings of the National Academy of Sciences of the United States of America, 106, 1, 256-261 Proceedings of the National Academy of Sciences of the United States of America, 106, 1, 256-261 Proceedings of the National Academy of Sciences of the United States of America, 106, 1, 256-261 2009/01 公開
Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW 4th Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW 4th Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW 4th A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature, 456, 7219, 259-263 Nature, 456, 7219, 259-263 Nature, 456, 7219, 259-263 2008/11 公開
Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, Taketo MM, Cooney GJ, Kraegen EW, James DE, Hu LH, Li J, Ye JM Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, Taketo MM, Cooney GJ, Kraegen EW, James DE, Hu LH, Li J, Ye JM Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, Taketo MM, Cooney GJ, Kraegen EW, James DE, Hu LH, Li J, Ye JM Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes, 57, 5, 1414-1418 Diabetes, 57, 5, 1414-1418 Diabetes, 57, 5, 1414-1418 2008/05 公開
Kojima Y, Miyoshi H, Clevers HC, Oshima M, Aoki M, Taketo MM Kojima Y, Miyoshi H, Clevers HC, Oshima M, Aoki M, Taketo MM Kojima Y, Miyoshi H, Clevers HC, Oshima M, Aoki M, Taketo MM Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling. Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling. Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling. The Journal of biological chemistry, 282, 32, 23532-23540 The Journal of biological chemistry, 282, 32, 23532-23540 The Journal of biological chemistry, 282, 32, 23532-23540 2007/08 公開
Aoki K, Aoki M, Sugai M, Harada N, Miyoshi H, Tsukamoto T, Mizoshita T, Tatematsu M, Seno H, Chiba T, Oshima M, Hsieh CL, Taketo MM Aoki K, Aoki M, Sugai M, Harada N, Miyoshi H, Tsukamoto T, Mizoshita T, Tatematsu M, Seno H, Chiba T, Oshima M, Hsieh CL, Taketo MM Aoki K, Aoki M, Sugai M, Harada N, Miyoshi H, Tsukamoto T, Mizoshita T, Tatematsu M, Seno H, Chiba T, Oshima M, Hsieh CL, Taketo MM Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells. Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells. Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells. Oncogene, 26, 24, 3511-3520 Oncogene, 26, 24, 3511-3520 Oncogene, 26, 24, 3511-3520 2007/05 公開
Kitamura T, Kometani K, Hashida H, Matsunaga A, Miyoshi H, Hosogi H, Aoki M, Oshima M, Hattori M, Takabayashi A, Minato N, Taketo MM Kitamura T, Kometani K, Hashida H, Matsunaga A, Miyoshi H, Hosogi H, Aoki M, Oshima M, Hattori M, Takabayashi A, Minato N, Taketo MM Kitamura T, Kometani K, Hashida H, Matsunaga A, Miyoshi H, Hosogi H, Aoki M, Oshima M, Hattori M, Takabayashi A, Minato N, Taketo MM SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. Nature genetics, 39, 4, 467-475 Nature genetics, 39, 4, 467-475 Nature genetics, 39, 4, 467-475 2007/04 公開
Maruyama T, Tanaka K, Suzuki J, Miyoshi H, Harada N, Nakamura T, Miyamoto Y, Kanatani A, Tamai Y Maruyama T, Tanaka K, Suzuki J, Miyoshi H, Harada N, Nakamura T, Miyamoto Y, Kanatani A, Tamai Y Maruyama T, Tanaka K, Suzuki J, Miyoshi H, Harada N, Nakamura T, Miyamoto Y, Kanatani A, Tamai Y Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice. Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice. Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice. The Journal of endocrinology, 191, 1, 197-205 The Journal of endocrinology, 191, 1, 197-205 The Journal of endocrinology, 191, 1, 197-205 2006/10 公開
Takeda H, Miyoshi H, Kojima Y, Oshima M, Taketo MM Takeda H, Miyoshi H, Kojima Y, Oshima M, Taketo MM Takeda H, Miyoshi H, Kojima Y, Oshima M, Taketo MM Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice. Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice. Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice. Oncogene, 25, 12, 1816-1820 Oncogene, 25, 12, 1816-1820 Oncogene, 25, 12, 1816-1820 2006/03 公開
Li Q, Ishikawa TO, Miyoshi H, Oshima M, Taketo MM Li Q, Ishikawa TO, Miyoshi H, Oshima M, Taketo MM Li Q, Ishikawa TO, Miyoshi H, Oshima M, Taketo MM A targeted mutation of Nkd1 impairs mouse spermatogenesis. A targeted mutation of Nkd1 impairs mouse spermatogenesis. A targeted mutation of Nkd1 impairs mouse spermatogenesis. The Journal of biological chemistry, 280, 4, 2831-2839 The Journal of biological chemistry, 280, 4, 2831-2839 The Journal of biological chemistry, 280, 4, 2831-2839 2005/01 公開
Takeda H, Miyoshi H, Tamai Y, Oshima M, Taketo MM Takeda H, Miyoshi H, Tamai Y, Oshima M, Taketo MM Takeda H, Miyoshi H, Tamai Y, Oshima M, Taketo MM Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas. Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas. Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas. British journal of cancer, 90, 3, 701-704 British journal of cancer, 90, 3, 701-704 British journal of cancer, 90, 3, 701-704 2004/02 公開
Okano S, Asano A, Kon Y, Miyoshi H, Watanabe T Okano S, Asano A, Kon Y, Miyoshi H, Watanabe T Okano S, Asano A, Kon Y, Miyoshi H, Watanabe T Genetic analysis of jumbled spine and ribs (Jsr) mutation affecting the vertebral development in mice. Genetic analysis of jumbled spine and ribs (Jsr) mutation affecting the vertebral development in mice. Genetic analysis of jumbled spine and ribs (Jsr) mutation affecting the vertebral development in mice. Biochemical genetics, 40, 9-10, 311-322 Biochemical genetics, 40, 9-10, 311-322 Biochemical genetics, 40, 9-10, 311-322 2002/10 公開
Nakau M, Miyoshi H, Seldin MF, Imamura M, Oshima M, Taketo MM Nakau M, Miyoshi H, Seldin MF, Imamura M, Oshima M, Taketo MM Nakau M, Miyoshi H, Seldin MF, Imamura M, Oshima M, Taketo MM Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Cancer research, 62, 16, 4549-4553 Cancer research, 62, 16, 4549-4553 Cancer research, 62, 16, 4549-4553 2002/08 公開
Miyoshi H, Nakau M, Ishikawa TO, Seldin MF, Oshima M, Taketo MM Miyoshi H, Nakau M, Ishikawa TO, Seldin MF, Oshima M, Taketo MM Miyoshi H, Nakau M, Ishikawa TO, Seldin MF, Oshima M, Taketo MM Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer research, 62, 8, 2261-2266 Cancer research, 62, 8, 2261-2266 Cancer research, 62, 8, 2261-2266 2002/04 公開
Harada N, Miyoshi H, Murai N, Oshima H, Tamai Y, Oshima M, Taketo MM Harada N, Miyoshi H, Murai N, Oshima H, Tamai Y, Oshima M, Taketo MM Harada N, Miyoshi H, Murai N, Oshima H, Tamai Y, Oshima M, Taketo MM Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin. Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin. Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin. Cancer research, 62, 7, 1971-1977 Cancer research, 62, 7, 1971-1977 Cancer research, 62, 7, 1971-1977 2002/04 公開
Takaku K, Miyoshi H, Matsunaga A, Oshima M, Sasaki N, Taketo MM Takaku K, Miyoshi H, Matsunaga A, Oshima M, Sasaki N, Taketo MM Takaku K, Miyoshi H, Matsunaga A, Oshima M, Sasaki N, Taketo MM Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice. Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice. Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice. Cancer research, 59, 24, 6113-6117 Cancer research, 59, 24, 6113-6117 Cancer research, 59, 24, 6113-6117 1999/12 公開
Miyoshi H, Kon Y, Seo KW, Jin HK, Hasegawa A, Watanabe T Miyoshi H, Kon Y, Seo KW, Jin HK, Hasegawa A, Watanabe T Miyoshi H, Kon Y, Seo KW, Jin HK, Hasegawa A, Watanabe T Jumbled spine and ribs (Jsr): a new mutation on mouse chromosome 5. Jumbled spine and ribs (Jsr): a new mutation on mouse chromosome 5. Jumbled spine and ribs (Jsr): a new mutation on mouse chromosome 5. Mammalian genome : official journal of the International Mammalian Genome Society, 10, 3, 213-217 Mammalian genome : official journal of the International Mammalian Genome Society, 10, 3, 213-217 Mammalian genome : official journal of the International Mammalian Genome Society, 10, 3, 213-217 1999/03 公開
Takaku K, Oshima M, Miyoshi H, Matsui M, Seldin MF, Taketo MM Takaku K, Oshima M, Miyoshi H, Matsui M, Seldin MF, Taketo MM Takaku K, Oshima M, Miyoshi H, Matsui M, Seldin MF, Taketo MM Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell, 92, 5, 645-656 Cell, 92, 5, 645-656 Cell, 92, 5, 645-656 1998/03 公開
Seo KW, Miyoshi H, Kon Y, Watanabe T Seo KW, Miyoshi H, Kon Y, Watanabe T Seo KW, Miyoshi H, Kon Y, Watanabe T Chromosomal mapping and developmental study of Tattered-Hokkaido (Tdho). Chromosomal mapping and developmental study of Tattered-Hokkaido (Tdho). Chromosomal mapping and developmental study of Tattered-Hokkaido (Tdho). Mammalian genome : official journal of the International Mammalian Genome Society, 8, 8, 578-580 Mammalian genome : official journal of the International Mammalian Genome Society, 8, 8, 578-580 Mammalian genome : official journal of the International Mammalian Genome Society, 8, 8, 578-580 1997/08 公開

  • <<
  • >>
  • 表示
タイトル言語:
外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
基盤研究(B) 代表 成体上皮細胞の組織アイデンティティを特定するエピジェネティック修飾の解明 (平成30年度分) 2018/04/01〜2019/03/31