髙倉 喜信

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氏名(漢字/フリガナ/アルファベット表記)
髙倉 喜信/タカクラ ヨシノブ/Yoshinobu Takakura
所属部署・職名(部局/所属/講座等/職名)
薬学研究科/薬学専攻病態機能解析学講座/教授
学部兼担
部局 所属 講座等 職名
薬学部
連絡先住所
種別 住所(日本語) 住所(英語)
職場 京都市左京区吉田下阿達町46-29
連絡先電話番号
種別 番号
職場 075-753-4615
所属学会(国内)
学会名(日本語) 学会名(英語)
日本薬学会
日本薬剤学会
日本薬物動態学会
日本DDS学会
日本癌学会
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
薬学修士 京都大学
薬学博士 京都大学
出身大学院・研究科等
大学名(日本語) 大学名(英語) 研究科名(日本語) 研究科名(英語) 専攻名(日本語) 専攻名(英語) 修了区分
京都大学 大学院薬学研究科修士課程薬学専攻 修了
出身学校・専攻等
大学名(日本語) 大学名(英語) 学部名(日本語) 学部名(英語) 学科名(日本語) 学科名(英語) 卒業区分
京都大学 薬学部薬学科 卒業
職歴
期間 組織名(日本語) 組織名(英語) 職名(日本語) 職名(英語)
研究分野(科研費分類コード)
科研費分類コード
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Takahashi Y, Araie Y, Nomura D, Takahashi Y, Sano K, Saji H, Takakura Y, Nishikawa M Takahashi Y, Araie Y, Nomura D, Takahashi Y, Sano K, Saji H, Takakura Y, Nishikawa M Takahashi Y, Araie Y, Nomura D, Takahashi Y, Sano K, Saji H, Takakura Y, Nishikawa M Construction of nanostructured DNA harbouring phosphorodiamidate morpholino oligonucleotide for controlled tissue distribution in mice. Construction of nanostructured DNA harbouring phosphorodiamidate morpholino oligonucleotide for controlled tissue distribution in mice. Construction of nanostructured DNA harbouring phosphorodiamidate morpholino oligonucleotide for controlled tissue distribution in mice. Journal of drug targeting, 26, 4, 373-381 Journal of drug targeting, 26, 4, 373-381 Journal of drug targeting, 26, 4, 373-381 2018/04 英語 公開
Charoenviriyakul C, Takahashi Y, Morishita M, Nishikawa M, Takakura Y Charoenviriyakul C, Takahashi Y, Morishita M, Nishikawa M, Takakura Y Charoenviriyakul C, Takahashi Y, Morishita M, Nishikawa M, Takakura Y Role of Extracellular Vesicle Surface Proteins in the Pharmacokinetics of Extracellular Vesicles. Role of Extracellular Vesicle Surface Proteins in the Pharmacokinetics of Extracellular Vesicles. Role of Extracellular Vesicle Surface Proteins in the Pharmacokinetics of Extracellular Vesicles. Molecular pharmaceutics, 15, 3, 1073-1080 Molecular pharmaceutics, 15, 3, 1073-1080 Molecular pharmaceutics, 15, 3, 1073-1080 2018/03 英語 公開
Tanaka Y, Nishikawa M, Mizukami Y, Kusamori K, Ogino Y, Nishimura S, Shimizu K, Konishi S, Takahashi Y, Takakura Y Tanaka Y, Nishikawa M, Mizukami Y, Kusamori K, Ogino Y, Nishimura S, Shimizu K, Konishi S, Takahashi Y, Takakura Y Tanaka Y, Nishikawa M, Mizukami Y, Kusamori K, Ogino Y, Nishimura S, Shimizu K, Konishi S, Takahashi Y, Takakura Y Control of polarization and tumoricidal activity of macrophages by multicellular spheroid formation. Control of polarization and tumoricidal activity of macrophages by multicellular spheroid formation. Control of polarization and tumoricidal activity of macrophages by multicellular spheroid formation. Journal of controlled release : official journal of the Controlled Release Society, 270, 177-183 Journal of controlled release : official journal of the Controlled Release Society, 270, 177-183 Journal of controlled release : official journal of the Controlled Release Society, 270, 177-183 2018/01 英語 公開
Hamana A, Takahashi Y, Tanioka A, Nishikawa M, Takakura Y Hamana A, Takahashi Y, Tanioka A, Nishikawa M, Takakura Y Hamana A, Takahashi Y, Tanioka A, Nishikawa M, Takakura Y Safe and effective interferon-beta gene therapy for the treatment of multiple sclerosis by regulating biological activity through the design of interferon-beta-galectin-9 fusion proteins. Safe and effective interferon-beta gene therapy for the treatment of multiple sclerosis by regulating biological activity through the design of interferon-beta-galectin-9 fusion proteins. Safe and effective interferon-beta gene therapy for the treatment of multiple sclerosis by regulating biological activity through the design of interferon-beta-galectin-9 fusion proteins. International journal of pharmaceutics, 536, 1, 310-317 International journal of pharmaceutics, 536, 1, 310-317 International journal of pharmaceutics, 536, 1, 310-317 2018/01 英語 公開
Yamashita T, Takahashi Y, Takakura Y Yamashita T, Takahashi Y, Takakura Y Yamashita T, Takahashi Y, Takakura Y Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application. Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application. Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application. Biological & pharmaceutical bulletin, 41, 6, 835-842 Biological & pharmaceutical bulletin, 41, 6, 835-842 Biological & pharmaceutical bulletin, 41, 6, 835-842 2018 英語 公開
Araie Y, Takahashi Y, Takahashi Y, Takakura Y, Nishikawa M Araie Y, Takahashi Y, Takahashi Y, Takakura Y, Nishikawa M Araie Y, Takahashi Y, Takahashi Y, Takakura Y, Nishikawa M Enhanced Activity of Immunosuppressive Oligodeoxynucleotides by Incorporating Them into Hexapod-Like Nanostructured DNA. Enhanced Activity of Immunosuppressive Oligodeoxynucleotides by Incorporating Them into Hexapod-Like Nanostructured DNA. Enhanced Activity of Immunosuppressive Oligodeoxynucleotides by Incorporating Them into Hexapod-Like Nanostructured DNA. Biological & pharmaceutical bulletin, 41, 4, 564-569 Biological & pharmaceutical bulletin, 41, 4, 564-569 Biological & pharmaceutical bulletin, 41, 4, 564-569 2018 英語 公開
Yamashita T, Shinotsuka H, Takahashi Y, Kato K, Nishikawa M, Takakura Y Yamashita T, Shinotsuka H, Takahashi Y, Kato K, Nishikawa M, Takakura Y Yamashita T, Shinotsuka H, Takahashi Y, Kato K, Nishikawa M, Takakura Y SELEX-Based Screening of Exosome-Tropic RNA. SELEX-Based Screening of Exosome-Tropic RNA. SELEX-Based Screening of Exosome-Tropic RNA. Biological & pharmaceutical bulletin, 40, 12, 2140-2145 Biological & pharmaceutical bulletin, 40, 12, 2140-2145 Biological & pharmaceutical bulletin, 40, 12, 2140-2145 2017/12 英語 公開
Morishita M, Takahashi Y, Nishikawa M, Ariizumi R, Takakura Y Morishita M, Takahashi Y, Nishikawa M, Ariizumi R, Takakura Y Morishita M, Takahashi Y, Nishikawa M, Ariizumi R, Takakura Y Enhanced Class I Tumor Antigen Presentation via Cytosolic Delivery of Exosomal Cargos by Tumor-Cell-Derived Exosomes Displaying a pH-Sensitive Fusogenic Peptide. Enhanced Class I Tumor Antigen Presentation via Cytosolic Delivery of Exosomal Cargos by Tumor-Cell-Derived Exosomes Displaying a pH-Sensitive Fusogenic Peptide. Enhanced Class I Tumor Antigen Presentation via Cytosolic Delivery of Exosomal Cargos by Tumor-Cell-Derived Exosomes Displaying a pH-Sensitive Fusogenic Peptide. Molecular pharmaceutics, 14, 11, 4079-4086 Molecular pharmaceutics, 14, 11, 4079-4086 Molecular pharmaceutics, 14, 11, 4079-4086 2017/11 英語 公開
Yata T, Takahashi Y, Tan M, Nakatsuji H, Ohtsuki S, Murakami T, Imahori H, Umeki Y, Shiomi T, Takakura Y, Nishikawa M Yata T, Takahashi Y, Tan M, Nakatsuji H, Ohtsuki S, Murakami T, Imahori H, Umeki Y, Shiomi T, Takakura Y, Nishikawa M Yata T, Takahashi Y, Tan M, Nakatsuji H, Ohtsuki S, Murakami T, Imahori H, Umeki Y, Shiomi T, Takakura Y, Nishikawa M DNA nanotechnology-based composite-type gold nanoparticle-immunostimulatory DNA hydrogel for tumor photothermal immunotherapy. DNA nanotechnology-based composite-type gold nanoparticle-immunostimulatory DNA hydrogel for tumor photothermal immunotherapy. DNA nanotechnology-based composite-type gold nanoparticle-immunostimulatory DNA hydrogel for tumor photothermal immunotherapy. Biomaterials, 146, 136-145 Biomaterials, 146, 136-145 Biomaterials, 146, 136-145 2017/11 英語 公開
Mohri K, Nagata K, Ohtsuki S, Toyama S, Nonomura M, Takahashi Y, Takakura Y, Nishikawa M, Sakuma S Mohri K, Nagata K, Ohtsuki S, Toyama S, Nonomura M, Takahashi Y, Takakura Y, Nishikawa M, Sakuma S Mohri K, Nagata K, Ohtsuki S, Toyama S, Nonomura M, Takahashi Y, Takakura Y, Nishikawa M, Sakuma S Elucidation of the Mechanism of Increased Activity of Immunostimulatory DNA by the Formation of Polypod-like Structure. Elucidation of the Mechanism of Increased Activity of Immunostimulatory DNA by the Formation of Polypod-like Structure. Elucidation of the Mechanism of Increased Activity of Immunostimulatory DNA by the Formation of Polypod-like Structure. Pharmaceutical research, 34, 11, 2362-2370 Pharmaceutical research, 34, 11, 2362-2370 Pharmaceutical research, 34, 11, 2362-2370 2017/11 英語 公開
Ohtsuki S, Takahashi Y, Inoue T, Takakura Y, Nishikawa M Ohtsuki S, Takahashi Y, Inoue T, Takakura Y, Nishikawa M Ohtsuki S, Takahashi Y, Inoue T, Takakura Y, Nishikawa M Reconstruction of Toll-like receptor 9-mediated responses in HEK-Blue hTLR9 cells by transfection of human macrophage scavenger receptor 1 gene. Reconstruction of Toll-like receptor 9-mediated responses in HEK-Blue hTLR9 cells by transfection of human macrophage scavenger receptor 1 gene. Reconstruction of Toll-like receptor 9-mediated responses in HEK-Blue hTLR9 cells by transfection of human macrophage scavenger receptor 1 gene. Scientific reports, 7, 1, 13661 Scientific reports, 7, 1, 13661 Scientific reports, 7, 1, 13661 2017/10 英語 公開
Hamana A, Takahashi Y, Uchida T, Nishikawa M, Imamura M, Chayama K, Takakura Y Hamana A, Takahashi Y, Uchida T, Nishikawa M, Imamura M, Chayama K, Takakura Y Hamana A, Takahashi Y, Uchida T, Nishikawa M, Imamura M, Chayama K, Takakura Y Evaluation of antiviral effect of type I, II, and III interferons on direct-acting antiviral-resistant hepatitis C virus. Evaluation of antiviral effect of type I, II, and III interferons on direct-acting antiviral-resistant hepatitis C virus. Evaluation of antiviral effect of type I, II, and III interferons on direct-acting antiviral-resistant hepatitis C virus. Antiviral research, 146, 130-138 Antiviral research, 146, 130-138 Antiviral research, 146, 130-138 2017/10 英語 公開
Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul C, Saji H, Takakura Y Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul C, Saji H, Takakura Y Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul C, Saji H, Takakura Y Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells. Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells. Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells. Cancer science Cancer science Cancer science 2017/07 英語 公開
Hamana A, Takahashi Y, Tanioka A, Nishikawa M, Takakura Y Hamana A, Takahashi Y, Tanioka A, Nishikawa M, Takakura Y Hamana A, Takahashi Y, Tanioka A, Nishikawa M, Takakura Y Amelioration of Experimental Autoimmune Encephalomyelitis in Mice by Interferon-Beta Gene Therapy, Using a Long-Term Expression Plasmid Vector. Amelioration of Experimental Autoimmune Encephalomyelitis in Mice by Interferon-Beta Gene Therapy, Using a Long-Term Expression Plasmid Vector. Amelioration of Experimental Autoimmune Encephalomyelitis in Mice by Interferon-Beta Gene Therapy, Using a Long-Term Expression Plasmid Vector. Molecular pharmaceutics, 14, 4, 1212-1217 Molecular pharmaceutics, 14, 4, 1212-1217 Molecular pharmaceutics, 14, 4, 1212-1217 2017/04 英語 公開
Takahashi Y, Maezawa T, Araie Y, Takahashi Y, Takakura Y, Nishikawa M Takahashi Y, Maezawa T, Araie Y, Takahashi Y, Takakura Y, Nishikawa M Takahashi Y, Maezawa T, Araie Y, Takahashi Y, Takakura Y, Nishikawa M In Vitro and In Vivo Stimulation of Toll-Like Receptor 9 by CpG Oligodeoxynucleotides Incorporated Into Polypod-Like DNA Nanostructures. In Vitro and In Vivo Stimulation of Toll-Like Receptor 9 by CpG Oligodeoxynucleotides Incorporated Into Polypod-Like DNA Nanostructures. In Vitro and In Vivo Stimulation of Toll-Like Receptor 9 by CpG Oligodeoxynucleotides Incorporated Into Polypod-Like DNA Nanostructures. Journal of pharmaceutical sciences Journal of pharmaceutical sciences Journal of pharmaceutical sciences 2017/04 英語 公開
Nishikawa T, Tanaka Y, Kusamori K, Mizuno N, Mizukami Y, Ogino Y, Shimizu K, Konishi S, Takahashi Y, Takakura Y, Nishikawa M Nishikawa T, Tanaka Y, Kusamori K, Mizuno N, Mizukami Y, Ogino Y, Shimizu K, Konishi S, Takahashi Y, Takakura Y, Nishikawa M Nishikawa T, Tanaka Y, Kusamori K, Mizuno N, Mizukami Y, Ogino Y, Shimizu K, Konishi S, Takahashi Y, Takakura Y, Nishikawa M Size-controlled multicellular spheroids of murine adenocarcinoma cells to efficiently establish pulmonary tumors in mice. Size-controlled multicellular spheroids of murine adenocarcinoma cells to efficiently establish pulmonary tumors in mice. Size-controlled multicellular spheroids of murine adenocarcinoma cells to efficiently establish pulmonary tumors in mice. Biotechnology journal Biotechnology journal Biotechnology journal 2017/04 英語 公開
Ando M, Fujimoto M, Takahashi Y, Nishikawa M, Hamana A, Takakura Y Ando M, Fujimoto M, Takahashi Y, Nishikawa M, Hamana A, Takakura Y Ando M, Fujimoto M, Takahashi Y, Nishikawa M, Hamana A, Takakura Y Targeted Delivery of Interferon Gamma Using a Recombinant Fusion Protein of a Fibrin Clot-Binding Peptide With Interferon Gamma for Cancer Gene Therapy. Targeted Delivery of Interferon Gamma Using a Recombinant Fusion Protein of a Fibrin Clot-Binding Peptide With Interferon Gamma for Cancer Gene Therapy. Targeted Delivery of Interferon Gamma Using a Recombinant Fusion Protein of a Fibrin Clot-Binding Peptide With Interferon Gamma for Cancer Gene Therapy. Journal of pharmaceutical sciences, 106, 3, 892-897 Journal of pharmaceutical sciences, 106, 3, 892-897 Journal of pharmaceutical sciences, 106, 3, 892-897 2017/03 英語 公開
Morishita M, Takahashi Y, Nishikawa M, Takakura Y Morishita M, Takahashi Y, Nishikawa M, Takakura Y Morishita M, Takahashi Y, Nishikawa M, Takakura Y Pharmacokinetics of Exosomes-An Important Factor for Elucidating the Biological Roles of Exosomes and for the Development of Exosome-Based Therapeutics. Pharmacokinetics of Exosomes-An Important Factor for Elucidating the Biological Roles of Exosomes and for the Development of Exosome-Based Therapeutics. Pharmacokinetics of Exosomes-An Important Factor for Elucidating the Biological Roles of Exosomes and for the Development of Exosome-Based Therapeutics. Journal of pharmaceutical sciences Journal of pharmaceutical sciences Journal of pharmaceutical sciences 2017/03 英語 公開
Ishii-Mizuno Y, Umeki Y, Onuki Y, Watanabe H, Takahashi Y, Takakura Y, Nishikawa M Ishii-Mizuno Y, Umeki Y, Onuki Y, Watanabe H, Takahashi Y, Takakura Y, Nishikawa M Ishii-Mizuno Y, Umeki Y, Onuki Y, Watanabe H, Takahashi Y, Takakura Y, Nishikawa M Improved sustained release of antigen from immunostimulatory DNA hydrogel by electrostatic interaction with chitosan. Improved sustained release of antigen from immunostimulatory DNA hydrogel by electrostatic interaction with chitosan. Improved sustained release of antigen from immunostimulatory DNA hydrogel by electrostatic interaction with chitosan. International journal of pharmaceutics, 516, 1-2, 392-400 International journal of pharmaceutics, 516, 1-2, 392-400 International journal of pharmaceutics, 516, 1-2, 392-400 2017/01 英語 公開
Charoenviriyakul C, Takahashi Y, Morishita M, Matsumoto A, Nishikawa M, Takakura Y Charoenviriyakul C, Takahashi Y, Morishita M, Matsumoto A, Nishikawa M, Takakura Y Charoenviriyakul C, Takahashi Y, Morishita M, Matsumoto A, Nishikawa M, Takakura Y Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics. Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics. Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 96, 316-322 European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 96, 316-322 European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 96, 316-322 2017/01 英語 公開
Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul C, Saji H, Takakura Y Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul C, Saji H, Takakura Y Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul C, Saji H, Takakura Y Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages. Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages. Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages. Journal of pharmaceutical sciences, 106, 1, 168-175 Journal of pharmaceutical sciences, 106, 1, 168-175 Journal of pharmaceutical sciences, 106, 1, 168-175 2017/01 英語 公開
Nishikawa T, Tanaka Y, Nishikawa M, Ogino Y, Kusamori K, Mizuno N, Mizukami Y, Shimizu K, Konishi S, Takahashi Y, Takakura Y Nishikawa T, Tanaka Y, Nishikawa M, Ogino Y, Kusamori K, Mizuno N, Mizukami Y, Shimizu K, Konishi S, Takahashi Y, Takakura Y Nishikawa T, Tanaka Y, Nishikawa M, Ogino Y, Kusamori K, Mizuno N, Mizukami Y, Shimizu K, Konishi S, Takahashi Y, Takakura Y Optimization of Albumin Secretion and Metabolic Activity of Cytochrome P450 1A1 of Human Hepatoblastoma HepG2 Cells in Multicellular Spheroids by Controlling Spheroid Size. Optimization of Albumin Secretion and Metabolic Activity of Cytochrome P450 1A1 of Human Hepatoblastoma HepG2 Cells in Multicellular Spheroids by Controlling Spheroid Size. Optimization of Albumin Secretion and Metabolic Activity of Cytochrome P450 1A1 of Human Hepatoblastoma HepG2 Cells in Multicellular Spheroids by Controlling Spheroid Size. Biological & pharmaceutical bulletin, 40, 3, 334-338 Biological & pharmaceutical bulletin, 40, 3, 334-338 Biological & pharmaceutical bulletin, 40, 3, 334-338 2017 英語 公開
Y. Umeki, M. Saito, Y. Takahashi, Y. Takakura, M. Nishikawa Y. Umeki, M. Saito, Y. Takahashi, Y. Takakura, M. Nishikawa Y. Umeki, M. Saito, Y. Takahashi, Y. Takakura, M. Nishikawa Retardation of Antigen Release from DNA Hydrogel Using Cholesterol-modified DNA for Increased Antigen-specific Immune Response Retardation of Antigen Release from DNA Hydrogel Using Cholesterol-modified DNA for Increased Antigen-specific Immune Response Retardation of Antigen Release from DNA Hydrogel Using Cholesterol-modified DNA for Increased Antigen-specific Immune Response Adv. Healthcare Mater Adv. Healthcare Mater 2017 英語 公開
Takahashi Y, Nishikawa M, Takakura Y Takahashi Y, Nishikawa M, Takakura Y Takahashi Y, Nishikawa M, Takakura Y In Vivo Tracking of Extracellular Vesicles in Mice Using Fusion Protein Comprising Lactadherin and Gaussia Luciferase. In Vivo Tracking of Extracellular Vesicles in Mice Using Fusion Protein Comprising Lactadherin and Gaussia Luciferase. In Vivo Tracking of Extracellular Vesicles in Mice Using Fusion Protein Comprising Lactadherin and Gaussia Luciferase. Methods in molecular biology (Clifton, N.J.), 1660, 245-254 Methods in molecular biology (Clifton, N.J.), 1660, 245-254 Methods in molecular biology (Clifton, N.J.), 1660, 245-254 2017 英語 公開
Morishita M, Takahashi Y, Matsumoto A, Nishikawa M, Takakura Y Morishita M, Takahashi Y, Matsumoto A, Nishikawa M, Takakura Y Morishita M, Takahashi Y, Matsumoto A, Nishikawa M, Takakura Y Exosome-based tumor antigens-adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA. Exosome-based tumor antigens-adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA. Exosome-based tumor antigens-adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA. Biomaterials, 111, 55-65 Biomaterials, 111, 55-65 Biomaterials, 111, 55-65 2016/12 英語 公開
Hamana A, Takahashi Y, Nishikawa M, Takakura Y Hamana A, Takahashi Y, Nishikawa M, Takakura Y Hamana A, Takahashi Y, Nishikawa M, Takakura Y Interferon-Inducible Mx Promoter-Driven, Long-Term Transgene Expression System of Interferon-β for Cancer Gene Therapy. Interferon-Inducible Mx Promoter-Driven, Long-Term Transgene Expression System of Interferon-β for Cancer Gene Therapy. Interferon-Inducible Mx Promoter-Driven, Long-Term Transgene Expression System of Interferon-β for Cancer Gene Therapy. Human gene therapy, 27, 11, 936-945 Human gene therapy, 27, 11, 936-945 Human gene therapy, 27, 11, 936-945 2016/11 英語 公開
Yin Y, Takahashi Y, Hamana A, Nishikawa M, Takakura Y Yin Y, Takahashi Y, Hamana A, Nishikawa M, Takakura Y Yin Y, Takahashi Y, Hamana A, Nishikawa M, Takakura Y Effects of transgene expression level per cell in mice livers on induction of transgene-specific immune responses after hydrodynamic gene transfer. Effects of transgene expression level per cell in mice livers on induction of transgene-specific immune responses after hydrodynamic gene transfer. Effects of transgene expression level per cell in mice livers on induction of transgene-specific immune responses after hydrodynamic gene transfer. Gene therapy, 23, 7, 565-571 Gene therapy, 23, 7, 565-571 Gene therapy, 23, 7, 565-571 2016/07 英語 公開
Murakami Y, Ishibashi T, Tomita E, Imamura Y, Tashiro T, Watcharanurak K, Nishikawa M, Takahashi Y, Takakura Y, Mitani S, Fujigaki H, Ohta Y, Kubo H, Mamiya T, Nabeshima T, Kim HC, Yamamoto Y, Saito K Murakami Y, Ishibashi T, Tomita E, Imamura Y, Tashiro T, Watcharanurak K, Nishikawa M, Takahashi Y, Takakura Y, Mitani S, Fujigaki H, Ohta Y, Kubo H, Mamiya T, Nabeshima T, Kim HC, Yamamoto Y, Saito K Murakami Y, Ishibashi T, Tomita E, Imamura Y, Tashiro T, Watcharanurak K, Nishikawa M, Takahashi Y, Takakura Y, Mitani S, Fujigaki H, Ohta Y, Kubo H, Mamiya T, Nabeshima T, Kim HC, Yamamoto Y, Saito K Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1. Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1. Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1. Scientific reports, 6 Scientific reports, 6 Scientific reports, 6 2016/07 英語 公開
Sanada Y, Shiomi T, Okobira T, Tan M, Nishikawa M, Akiba I, Takakura Y, Sakurai K Sanada Y, Shiomi T, Okobira T, Tan M, Nishikawa M, Akiba I, Takakura Y, Sakurai K Sanada Y, Shiomi T, Okobira T, Tan M, Nishikawa M, Akiba I, Takakura Y, Sakurai K Polypod-Shaped DNAs: Small-Angle X-ray Scattering and Immunostimulatory Activity. Polypod-Shaped DNAs: Small-Angle X-ray Scattering and Immunostimulatory Activity. Polypod-Shaped DNAs: Small-Angle X-ray Scattering and Immunostimulatory Activity. Langmuir : the ACS journal of surfaces and colloids, 32, 15, 3760-3765 Langmuir : the ACS journal of surfaces and colloids, 32, 15, 3760-3765 Langmuir : the ACS journal of surfaces and colloids, 32, 15, 3760-3765 2016/04 英語 公開
Takagi S, Takahashi Y, Sugimura K, Nishikawa M, Takakura Y Takagi S, Takahashi Y, Sugimura K, Nishikawa M, Takakura Y Takagi S, Takahashi Y, Sugimura K, Nishikawa M, Takakura Y Application of Magnesium Pyrophosphate-Based Sponge-Like Microparticles to Enhance the Delivery Efficiency and Adjuvant Effects of Polyriboinosinic-Polyribocytidylic Acid in Immune Cells. Application of Magnesium Pyrophosphate-Based Sponge-Like Microparticles to Enhance the Delivery Efficiency and Adjuvant Effects of Polyriboinosinic-Polyribocytidylic Acid in Immune Cells. Application of Magnesium Pyrophosphate-Based Sponge-Like Microparticles to Enhance the Delivery Efficiency and Adjuvant Effects of Polyriboinosinic-Polyribocytidylic Acid in Immune Cells. Journal of pharmaceutical sciences, 105, 2, 766-772 Journal of pharmaceutical sciences, 105, 2, 766-772 Journal of pharmaceutical sciences, 105, 2, 766-772 2016/02 英語 公開
Yamashita T, Takahashi Y, Nishikawa M, Takakura Y Yamashita T, Takahashi Y, Nishikawa M, Takakura Y Yamashita T, Takahashi Y, Nishikawa M, Takakura Y Effect of exosome isolation methods on physicochemical properties of exosomes and clearance of exosomes from the blood circulation. Effect of exosome isolation methods on physicochemical properties of exosomes and clearance of exosomes from the blood circulation. Effect of exosome isolation methods on physicochemical properties of exosomes and clearance of exosomes from the blood circulation. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 98, 1-8 European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 98, 1-8 European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 98, 1-8 2016/01 英語 公開
Nishida Y, Ohtsuki S, Araie Y, Umeki Y, Endo M, Emura T, Hidaka K, Sugiyama H, Takahashi Y, Takakura Y, Nishikawa M Nishida Y, Ohtsuki S, Araie Y, Umeki Y, Endo M, Emura T, Hidaka K, Sugiyama H, Takahashi Y, Takakura Y, Nishikawa M Nishida Y, Ohtsuki S, Araie Y, Umeki Y, Endo M, Emura T, Hidaka K, Sugiyama H, Takahashi Y, Takakura Y, Nishikawa M Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells. Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells. Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells. Nanomedicine : nanotechnology, biology, and medicine, 12, 1, 123-130 Nanomedicine : nanotechnology, biology, and medicine, 12, 1, 123-130 Nanomedicine : nanotechnology, biology, and medicine, 12, 1, 123-130 2016/01 英語 公開
Kusamori K, Nishikawa M, Mizuno N, Nishikawa T, Masuzawa A, Tanaka Y, Mizukami Y, Shimizu K, Konishi S, Takahashi Y, Takakura Y Kusamori K, Nishikawa M, Mizuno N, Nishikawa T, Masuzawa A, Tanaka Y, Mizukami Y, Shimizu K, Konishi S, Takahashi Y, Takakura Y Kusamori K, Nishikawa M, Mizuno N, Nishikawa T, Masuzawa A, Tanaka Y, Mizukami Y, Shimizu K, Konishi S, Takahashi Y, Takakura Y Increased Insulin Secretion from Insulin-Secreting Cells by Construction of Mixed Multicellular Spheroids. Increased Insulin Secretion from Insulin-Secreting Cells by Construction of Mixed Multicellular Spheroids. Increased Insulin Secretion from Insulin-Secreting Cells by Construction of Mixed Multicellular Spheroids. Pharmaceutical research, 33, 1, 247-256 Pharmaceutical research, 33, 1, 247-256 Pharmaceutical research, 33, 1, 247-256 2016/01 英語 公開
Takahashi Y, Nishikawa M, Takakura Y Takahashi Y, Nishikawa M, Takakura Y Takahashi Y, Nishikawa M, Takakura Y [Analysis and Control of in Vivo Kinetics of Exosomes for the Development of Exosome-based DDS]. [Analysis and Control of in Vivo Kinetics of Exosomes for the Development of Exosome-based DDS]. [Analysis and Control of in Vivo Kinetics of Exosomes for the Development of Exosome-based DDS]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 136, 1, 49-53 Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 136, 1, 49-53 Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 136, 1, 49-53 2016 公開
Zang L, Nishikawa M, Ando M, Takahashi Y, Takakura Y Zang L, Nishikawa M, Ando M, Takahashi Y, Takakura Y Zang L, Nishikawa M, Ando M, Takahashi Y, Takakura Y Contribution of Epigenetic Modifications to the Decline in Transgene Expression from Plasmid DNA in Mouse Liver. Contribution of Epigenetic Modifications to the Decline in Transgene Expression from Plasmid DNA in Mouse Liver. Contribution of Epigenetic Modifications to the Decline in Transgene Expression from Plasmid DNA in Mouse Liver. Pharmaceutics, 7, 3, 199-212 Pharmaceutics, 7, 3, 199-212 Pharmaceutics, 7, 3, 199-212 2015/08 英語 公開
Mohri K, Kusuki E, Ohtsuki S, Takahashi N, Endo M, Hidaka K, Sugiyama H, Takahashi Y, Takakura Y, Nishikawa M Mohri K, Kusuki E, Ohtsuki S, Takahashi N, Endo M, Hidaka K, Sugiyama H, Takahashi Y, Takakura Y, Nishikawa M Mohri K, Kusuki E, Ohtsuki S, Takahashi N, Endo M, Hidaka K, Sugiyama H, Takahashi Y, Takakura Y, Nishikawa M Self-assembling DNA dendrimer for effective delivery of immunostimulatory CpG DNA to immune cells. Self-assembling DNA dendrimer for effective delivery of immunostimulatory CpG DNA to immune cells. Self-assembling DNA dendrimer for effective delivery of immunostimulatory CpG DNA to immune cells. Biomacromolecules, 16, 4, 1095-1101 Biomacromolecules, 16, 4, 1095-1101 Biomacromolecules, 16, 4, 1095-1101 2015/04 英語 公開
Morishita M, Takahashi Y, Nishikawa M, Sano K, Kato K, Yamashita T, Imai T, Saji H, Takakura Y Morishita M, Takahashi Y, Nishikawa M, Sano K, Kato K, Yamashita T, Imai T, Saji H, Takakura Y Morishita M, Takahashi Y, Nishikawa M, Sano K, Kato K, Yamashita T, Imai T, Saji H, Takakura Y Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative after intravenous injection in mice. Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative after intravenous injection in mice. Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative after intravenous injection in mice. Journal of pharmaceutical sciences, 104, 2, 705-713 Journal of pharmaceutical sciences, 104, 2, 705-713 Journal of pharmaceutical sciences, 104, 2, 705-713 2015/02 英語 公開
Ishii-Mizuno Y, Umeki Y, Takahashi Y, Kato Y, Takabayashi T, Fujieda S, Takakura Y, Nishikawa M Ishii-Mizuno Y, Umeki Y, Takahashi Y, Kato Y, Takabayashi T, Fujieda S, Takakura Y, Nishikawa M Ishii-Mizuno Y, Umeki Y, Takahashi Y, Kato Y, Takabayashi T, Fujieda S, Takakura Y, Nishikawa M Nasal delivery of Japanese cedar pollen Cryj1 by using self-gelling immunostimulatory DNA for effective induction of immune responses in mice. Nasal delivery of Japanese cedar pollen Cryj1 by using self-gelling immunostimulatory DNA for effective induction of immune responses in mice. Nasal delivery of Japanese cedar pollen Cryj1 by using self-gelling immunostimulatory DNA for effective induction of immune responses in mice. Journal of controlled release : official journal of the Controlled Release Society, 200, 52-59 Journal of controlled release : official journal of the Controlled Release Society, 200, 52-59 Journal of controlled release : official journal of the Controlled Release Society, 200, 52-59 2015/02 英語 公開
Y.Umeki, K. Mohri, Y. Kawasaki, H. Watanabe, R. Takahashi, Y. Takahashi, Y. Takakura, M. Nishikawa Y.Umeki, K. Mohri, Y. Kawasaki, H. Watanabe, R. Takahashi, Y. Takahashi, Y. Takakura, M. Nishikawa Y.Umeki, K. Mohri, Y. Kawasaki, H. Watanabe, R. Takahashi, Y. Takahashi, Y. Takakura, M. Nishikawa Induction of Potent Antitumor Immunity by Sustained Release of Cationic Antigen from a DNA-based Hydrogel with Adjuvant Activity Induction of Potent Antitumor Immunity by Sustained Release of Cationic Antigen from a DNA-based Hydrogel with Adjuvant Activity Induction of Potent Antitumor Immunity by Sustained Release of Cationic Antigen from a DNA-based Hydrogel with Adjuvant Activity Ad. Funct. Mater.,, 25, 36, 5758-5767 Ad. Funct. Mater.,, 25, 36, 5758-5767 Ad. Funct. Mater.,, 25, 36, 5758-5767 2015 英語 公開
T. Shiomi, M. Tan, N. Takahashi, M. Endo, T. Emura, K. Hidaka, H. Sugiyama, Y.Takahashi, Y. Takakura, M. Nishikawa T. Shiomi, M. Tan, N. Takahashi, M. Endo, T. Emura, K. Hidaka, H. Sugiyama, Y.Takahashi, Y. Takakura, M. Nishikawa T. Shiomi, M. Tan, N. Takahashi, M. Endo, T. Emura, K. Hidaka, H. Sugiyama, Y.Takahashi, Y. Takakura, M. Nishikawa Atomic Force Microscopy Analysis of Orientation and Bending of Oligodeoxynucleotides in Polypod-like Structured DNA Atomic Force Microscopy Analysis of Orientation and Bending of Oligodeoxynucleotides in Polypod-like Structured DNA Atomic Force Microscopy Analysis of Orientation and Bending of Oligodeoxynucleotides in Polypod-like Structured DNA Nano Res.,, 8, 12, 3771 Nano Res.,, 8, 12, 3771 Nano Res.,, 8, 12, 3771 2015 英語 公開
Imai T, Takahashi Y, Nishikawa M, Kato K, Morishita M, Yamashita T, Matsumoto A, Charoenviriyakul C, Takakura Y Imai T, Takahashi Y, Nishikawa M, Kato K, Morishita M, Yamashita T, Matsumoto A, Charoenviriyakul C, Takakura Y Imai T, Takahashi Y, Nishikawa M, Kato K, Morishita M, Yamashita T, Matsumoto A, Charoenviriyakul C, Takakura Y Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice. Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice. Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice. Journal of extracellular vesicles, 4, 26238 Journal of extracellular vesicles, 4, 26238 Journal of extracellular vesicles, 4, 26238 2015 英語 公開
K. Kusamori, M. Nishikawa, N. Mizuno, T. Nishikawa, A. Masuzawa, Y. Tanaka, Y. Mizukami, K. Shimizu, S. Konishi, Y. Takahashi, Y. Takakura K. Kusamori, M. Nishikawa, N. Mizuno, T. Nishikawa, A. Masuzawa, Y. Tanaka, Y. Mizukami, K. Shimizu, S. Konishi, Y. Takahashi, Y. Takakura K. Kusamori, M. Nishikawa, N. Mizuno, T. Nishikawa, A. Masuzawa, Y. Tanaka, Y. Mizukami, K. Shimizu, S. Konishi, Y. Takahashi, Y. Takakura Increased insulin secretion from insulin-secreting cells by construction of mixed multicellular spheroids Increased insulin secretion from insulin-secreting cells by construction of mixed multicellular spheroids Increased insulin secretion from insulin-secreting cells by construction of mixed multicellular spheroids Pharmaceutical Research,, 33, 1, 247-256 Pharmaceutical Research,, 33, 1, 247-256 Pharmaceutical Research,, 33, 1, 247-256 2015 英語 公開
Y. Nishida, S. Ohtsuki, Y. Araie, Y. Umeki, M. Endo, T. Emura, , K. Hidaka, H. Sugiyama, Y. Takahashi, Y. Takakura, M. Nishikawa Y. Nishida, S. Ohtsuki, Y. Araie, Y. Umeki, M. Endo, T. Emura, , K. Hidaka, H. Sugiyama, Y. Takahashi, Y. Takakura, M. Nishikawa Y. Nishida, S. Ohtsuki, Y. Araie, Y. Umeki, M. Endo, T. Emura, , K. Hidaka, H. Sugiyama, Y. Takahashi, Y. Takakura, M. Nishikawa Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells Nanomedicine-Nanotechnology Biology and Medicine, in R[8]Cpress, 12, 1, 123-130 Nanomedicine-Nanotechnology Biology and Medicine, in R[8]Cpress, 12, 1, 123-130 Nanomedicine-Nanotechnology Biology and Medicine, in R[8]Cpress, 12, 1, 123-130 2015 英語 公開
Shozo Ohtsuki, Noriyuki Matsuzaki, Kohta Mohri, Masayuki Endo, Tomoko Emura, Kumi Hidaka, Hiroshi Sugiyama, Yuki Takahashi, Kenichi Ishiyama, Norimitsu Kadowaki, Yoshinobu Takakura, Makiya Nishikawa Shozo Ohtsuki, Noriyuki Matsuzaki, Kohta Mohri, Masayuki Endo, Tomoko Emura, Kumi Hidaka, Hiroshi Sugiyama, Yuki Takahashi, Kenichi Ishiyama, Norimitsu Kadowaki, Yoshinobu Takakura, Makiya Nishikawa Shozo Ohtsuki, Noriyuki Matsuzaki, Kohta Mohri, Masayuki Endo, Tomoko Emura, Kumi Hidaka, Hiroshi Sugiyama, Yuki Takahashi, Kenichi Ishiyama, Norimitsu Kadowaki, Yoshinobu Takakura, Makiya Nishikawa Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulatory Nucleic Acids to Immune Cells Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulatory Nucleic Acids to Immune Cells Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulatory Nucleic Acids to Immune Cells Nucleic Acid Therapeutics, 25, 5, 245-253 Nucleic Acid Therapeutics, 25, 5, 245-253 Nucleic Acid Therapeutics, 25, 5, 245-253 2015 英語 公開
Tomoya Yata, Yuki Takahashi, Kumi Hidaka, Masayuki Endo, Hiroshi Sugiyama,Mengmeng Tan, Yoshinobu Takakura, Makiya Nishikawa Tomoya Yata, Yuki Takahashi, Kumi Hidaka, Masayuki Endo, Hiroshi Sugiyama,Mengmeng Tan, Yoshinobu Takakura, Makiya Nishikawa Tomoya Yata, Yuki Takahashi, Kumi Hidaka, Masayuki Endo, Hiroshi Sugiyama,Mengmeng Tan, Yoshinobu Takakura, Makiya Nishikawa Efficient amplification of self-gelling polypod-like structured DNA by rolling circle amplification and enzymatic digestion Efficient amplification of self-gelling polypod-like structured DNA by rolling circle amplification and enzymatic digestion Efficient amplification of self-gelling polypod-like structured DNA by rolling circle amplification and enzymatic digestion Scientific Reports, in press, 5 Scientific Reports, in press, 5 Scientific Reports, in press, 5 2015 英語 公開
Frisco-Cabanos HL, Watanabe M, Okumura N, Kusamori K, Takemoto N, Takaya J, Sato S, Yamazoe S, Takakura Y, Kinoshita S, Nishikawa M, Koizumi N, Uesugi M Frisco-Cabanos HL, Watanabe M, Okumura N, Kusamori K, Takemoto N, Takaya J, Sato S, Yamazoe S, Takakura Y, Kinoshita S, Nishikawa M, Koizumi N, Uesugi M Frisco-Cabanos HL, Watanabe M, Okumura N, Kusamori K, Takemoto N, Takaya J, Sato S, Yamazoe S, Takakura Y, Kinoshita S, Nishikawa M, Koizumi N, Uesugi M Synthetic molecules that protect cells from anoikis and their use in cell transplantation. Synthetic molecules that protect cells from anoikis and their use in cell transplantation. Synthetic molecules that protect cells from anoikis and their use in cell transplantation. Angewandte Chemie (International ed. in English), 53, 42, 11208-11213 Angewandte Chemie (International ed. in English), 53, 42, 11208-11213 Angewandte Chemie (International ed. in English), 53, 42, 11208-11213 2014/10 英語 公開
Watcharanurak K, Zang L, Nishikawa M, Yoshinaga K, Yamamoto Y, Takahashi Y, Ando M, Saito K, Watanabe Y, Takakura Y Watcharanurak K, Zang L, Nishikawa M, Yoshinaga K, Yamamoto Y, Takahashi Y, Ando M, Saito K, Watanabe Y, Takakura Y Watcharanurak K, Zang L, Nishikawa M, Yoshinaga K, Yamamoto Y, Takahashi Y, Ando M, Saito K, Watanabe Y, Takakura Y Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity. Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity. Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity. Gene therapy, 21, 9, 794-801 Gene therapy, 21, 9, 794-801 Gene therapy, 21, 9, 794-801 2014/09 公開
Sanada Y, Sakamoto S, Shiomi T, Okobira T, Mylonas E, Ohta N, Yagi N, Nishikawa M, Akiba I, Takakura Y, Sakurai K Sanada Y, Sakamoto S, Shiomi T, Okobira T, Mylonas E, Ohta N, Yagi N, Nishikawa M, Akiba I, Takakura Y, Sakurai K Sanada Y, Sakamoto S, Shiomi T, Okobira T, Mylonas E, Ohta N, Yagi N, Nishikawa M, Akiba I, Takakura Y, Sakurai K X-ray scattering from immunostimulatory tetrapod-shaped DNA in aqueous solution to explore its biological activity-conformation relationship. X-ray scattering from immunostimulatory tetrapod-shaped DNA in aqueous solution to explore its biological activity-conformation relationship. X-ray scattering from immunostimulatory tetrapod-shaped DNA in aqueous solution to explore its biological activity-conformation relationship. The journal of physical chemistry. B, 118, 35, 10373-10379 The journal of physical chemistry. B, 118, 35, 10373-10379 The journal of physical chemistry. B, 118, 35, 10373-10379 2014/09 英語 公開
Mohri K, Nishikawa M, Takahashi Y, Takakura Y Mohri K, Nishikawa M, Takahashi Y, Takakura Y Mohri K, Nishikawa M, Takahashi Y, Takakura Y DNA nanotechnology-based development of delivery systems for bioactive compounds. DNA nanotechnology-based development of delivery systems for bioactive compounds. DNA nanotechnology-based development of delivery systems for bioactive compounds. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 58, 1, 26-33 European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 58, 1, 26-33 European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 58, 1, 26-33 2014/07 英語 公開
Kiyota T, Takahashi Y, Watcharanurak K, Nishikawa M, Ohara S, Ando M, Watanabe Y, Takakura Y Kiyota T, Takahashi Y, Watcharanurak K, Nishikawa M, Ohara S, Ando M, Watanabe Y, Takakura Y Kiyota T, Takahashi Y, Watcharanurak K, Nishikawa M, Ohara S, Ando M, Watanabe Y, Takakura Y Enhancement of anticancer effect of interferon-γ gene transfer against interferon-γ-resistant tumor by depletion of tumor-associated macrophages. Enhancement of anticancer effect of interferon-γ gene transfer against interferon-γ-resistant tumor by depletion of tumor-associated macrophages. Enhancement of anticancer effect of interferon-γ gene transfer against interferon-γ-resistant tumor by depletion of tumor-associated macrophages. Molecular pharmaceutics, 11, 5, 1542-1549 Molecular pharmaceutics, 11, 5, 1542-1549 Molecular pharmaceutics, 11, 5, 1542-1549 2014/05 英語 公開
S. Uno; M. Nishikawa; K. Mohri; Y. Umeki; N. Matsuzaki; Y. Takahashi; H. Fujita; N. Kadowaki; Y. Takakura S. Uno; M. Nishikawa; K. Mohri; Y. Umeki; N. Matsuzaki; Y. Takahashi; H. Fujita; N. Kadowaki; Y. Takakura S. Uno; M. Nishikawa; K. Mohri; Y. Umeki; N. Matsuzaki; Y. Takahashi; H. Fujita; N. Kadowaki; Y. Takakura Efficient delivery of immunostimulatory DNA to mouse and human immune cells through the construction of polypod-like structured DNA Efficient delivery of immunostimulatory DNA to mouse and human immune cells through the construction of polypod-like structured DNA Efficient delivery of immunostimulatory DNA to mouse and human immune cells through the construction of polypod-like structured DNA Nanomedicine: Nanotechnology, Biology, and Medicine, 10, 4, 765-774 Nanomedicine: Nanotechnology, Biology, and Medicine, 10, 4, 765-774 Nanomedicine: Nanotechnology, Biology, and Medicine, 10, 4, 765-774 2014/05 英語 公開
M. Nishikawa; K. Ogawa; Y. Umeki; K. Mohri; Y. Kawasaki; H. Watanabe; N. Takahashi; E. Kusuki; R. Takahashi; Y. Takahashi; Y. Takakura M. Nishikawa; K. Ogawa; Y. Umeki; K. Mohri; Y. Kawasaki; H. Watanabe; N. Takahashi; E. Kusuki; R. Takahashi; Y. Takahashi; Y. Takakura M. Nishikawa; K. Ogawa; Y. Umeki; K. Mohri; Y. Kawasaki; H. Watanabe; N. Takahashi; E. Kusuki; R. Takahashi; Y. Takahashi; Y. Takakura Injectable, self-gelling, biodegradable, and immunomodulatory DNA hydrogel for antigen delivery Injectable, self-gelling, biodegradable, and immunomodulatory DNA hydrogel for antigen delivery Injectable, self-gelling, biodegradable, and immunomodulatory DNA hydrogel for antigen delivery Journal of Controlled Release, 180, 25-32 Journal of Controlled Release, 180, 25-32 Journal of Controlled Release, 180, 25-32 2014/04 英語 公開
Takahashi Y, Ando M, Nishikawa M, Hiraga N, Imamura M, Chayama K, Takakura Y Takahashi Y, Ando M, Nishikawa M, Hiraga N, Imamura M, Chayama K, Takakura Y Takahashi Y, Ando M, Nishikawa M, Hiraga N, Imamura M, Chayama K, Takakura Y Long-term elimination of hepatitis C virus from human hepatocyte chimeric mice after interferon-γ gene transfer. Long-term elimination of hepatitis C virus from human hepatocyte chimeric mice after interferon-γ gene transfer. Long-term elimination of hepatitis C virus from human hepatocyte chimeric mice after interferon-γ gene transfer. Human gene therapy. Clinical development, 25, 1, 28-39 Human gene therapy. Clinical development, 25, 1, 28-39 Human gene therapy. Clinical development, 25, 1, 28-39 2014/03 英語 公開
Yin Y, Takahashi Y, Ebisuura N, Nishikawa M, Takakura Y Yin Y, Takahashi Y, Ebisuura N, Nishikawa M, Takakura Y Yin Y, Takahashi Y, Ebisuura N, Nishikawa M, Takakura Y Removal of transgene-expressing cells by a specific immune response induced by sustained transgene expression. Removal of transgene-expressing cells by a specific immune response induced by sustained transgene expression. Removal of transgene-expressing cells by a specific immune response induced by sustained transgene expression. The journal of gene medicine, 16, 3-4, 97-106 The journal of gene medicine, 16, 3-4, 97-106 The journal of gene medicine, 16, 3-4, 97-106 2014/03 英語 公開
K. Kusamori; M. Nishikawa; N. Mizuno; T. Nishikawa; A. Masuzawa; K. Shimizu; S. Konishi; Y. Takahashi; Y. Takakura K. Kusamori; M. Nishikawa; N. Mizuno; T. Nishikawa; A. Masuzawa; K. Shimizu; S. Konishi; Y. Takahashi; Y. Takakura K. Kusamori; M. Nishikawa; N. Mizuno; T. Nishikawa; A. Masuzawa; K. Shimizu; S. Konishi; Y. Takahashi; Y. Takakura Transplantation of insulin-secreting multicellular spheroids for the treatment of type 1 diabetes in mice Transplantation of insulin-secreting multicellular spheroids for the treatment of type 1 diabetes in mice Transplantation of insulin-secreting multicellular spheroids for the treatment of type 1 diabetes in mice Journal of Controlled Release, 173, 119-124 Journal of Controlled Release, 173, 119-124 Journal of Controlled Release, 173, 119-124 2014/01 英語 公開
Ando M, Takahashi Y, Yamashita T, Fujimoto M, Nishikawa M, Watanabe Y, Takakura Y Ando M, Takahashi Y, Yamashita T, Fujimoto M, Nishikawa M, Watanabe Y, Takakura Y Ando M, Takahashi Y, Yamashita T, Fujimoto M, Nishikawa M, Watanabe Y, Takakura Y Prevention of adverse events of interferon γ gene therapy by gene delivery of interferon γ-heparin-binding domain fusion protein in mice. Prevention of adverse events of interferon γ gene therapy by gene delivery of interferon γ-heparin-binding domain fusion protein in mice. Prevention of adverse events of interferon γ gene therapy by gene delivery of interferon γ-heparin-binding domain fusion protein in mice. Molecular therapy. Methods & clinical development, 1 Molecular therapy. Methods & clinical development, 1 Molecular therapy. Methods & clinical development, 1 2014 英語 公開
H. Mukumoto; Y. Takahashi; M. Ando; M. Nishikawa; Y. Takakura H. Mukumoto; Y. Takahashi; M. Ando; M. Nishikawa; Y. Takakura H. Mukumoto; Y. Takahashi; M. Ando; M. Nishikawa; Y. Takakura Expression profile-dependent improvement of insulin sensitivity by gene delivery of interleukin-6 in a mouse model of type II diabetes Expression profile-dependent improvement of insulin sensitivity by gene delivery of interleukin-6 in a mouse model of type II diabetes Expression profile-dependent improvement of insulin sensitivity by gene delivery of interleukin-6 in a mouse model of type II diabetes Molecular Pharmaceutics, 10, 10, 3812-3821 Molecular Pharmaceutics, 10, 10, 3812-3821 Molecular Pharmaceutics, 10, 10, 3812-3821 2013/10 英語 公開
N. Miyakawa; M. Nishikawa; Y. Takahashi; M. Ando; M. Misaka; Y. Watanabe; Y. Takakura N. Miyakawa; M. Nishikawa; Y. Takahashi; M. Ando; M. Misaka; Y. Watanabe; Y. Takakura N. Miyakawa; M. Nishikawa; Y. Takahashi; M. Ando; M. Misaka; Y. Watanabe; Y. Takakura Gene delivery of albumin binding peptide-interferon-gamma fusion protein with improved pharmacokinetic properties and sustained biological activity Gene delivery of albumin binding peptide-interferon-gamma fusion protein with improved pharmacokinetic properties and sustained biological activity Gene delivery of albumin binding peptide-interferon-gamma fusion protein with improved pharmacokinetic properties and sustained biological activity Journal of Pharmaceutical Sciences, 102, 9, 3110-3118 Journal of Pharmaceutical Sciences, 102, 9, 3110-3118 Journal of Pharmaceutical Sciences, 102, 9, 3110-3118 2013/09 英語 公開
N. Takemoto; T. Suehara; H.L. Frisco; S.-I. Sato; T. Sezaki; K. Kusamori; Y. Kawazoe; S.M. Park; S. Yamazoe; Y. Mizuhata; R. Inoue; G.J. Miller; S.U. Hansen; G.C. Jayson; J.M. Gardiner; T. Kanaya; N. Tokitoh; K. Ueda; Y. Takakura; N. Kioka; M. Nishikawa; M. Uesugi N. Takemoto; T. Suehara; H.L. Frisco; S.-I. Sato; T. Sezaki; K. Kusamori; Y. Kawazoe; S.M. Park; S. Yamazoe; Y. Mizuhata; R. Inoue; G.J. Miller; S.U. Hansen; G.C. Jayson; J.M. Gardiner; T. Kanaya; N. Tokitoh; K. Ueda; Y. Takakura; N. Kioka; M. Nishikawa; M. Uesugi N. Takemoto; T. Suehara; H.L. Frisco; S.-I. Sato; T. Sezaki; K. Kusamori; Y. Kawazoe; S.M. Park; S. Yamazoe; Y. Mizuhata; R. Inoue; G.J. Miller; S.U. Hansen; G.C. Jayson; J.M. Gardiner; T. Kanaya; N. Tokitoh; K. Ueda; Y. Takakura; N. Kioka; M. Nishikawa; M. Uesugi Small-molecule-induced clustering of heparan sulfate promotes cell adhesion Small-molecule-induced clustering of heparan sulfate promotes cell adhesion Small-molecule-induced clustering of heparan sulfate promotes cell adhesion Journal of the American Chemical Society, 135, 30, 11032-11039 Journal of the American Chemical Society, 135, 30, 11032-11039 Journal of the American Chemical Society, 135, 30, 11032-11039 2013/07 英語 公開
K. Shimizu; K. Kusamori; M. Nishikawa; N. Mizuno; T. Nishikawa; A. Masuzawa; S. Katano; Y. Takahashi; Y. Takakura; S. Konishi K. Shimizu; K. Kusamori; M. Nishikawa; N. Mizuno; T. Nishikawa; A. Masuzawa; S. Katano; Y. Takahashi; Y. Takakura; S. Konishi K. Shimizu; K. Kusamori; M. Nishikawa; N. Mizuno; T. Nishikawa; A. Masuzawa; S. Katano; Y. Takahashi; Y. Takakura; S. Konishi Poly(N-isopropylacrylamide)-coated microwell arrays for construction and recovery of multicellular spheroids Poly(N-isopropylacrylamide)-coated microwell arrays for construction and recovery of multicellular spheroids Poly(N-isopropylacrylamide)-coated microwell arrays for construction and recovery of multicellular spheroids Journal of Bioscience and Bioengineering, 115, 6, 695-699 Journal of Bioscience and Bioengineering, 115, 6, 695-699 Journal of Bioscience and Bioengineering, 115, 6, 695-699 2013/06 英語 公開
Y. Takahashi; M. Nishikawa; H. Shinotsuka; Y. Matsui; S. Ohara; T. Imai; Y. Takakura Y. Takahashi; M. Nishikawa; H. Shinotsuka; Y. Matsui; S. Ohara; T. Imai; Y. Takakura Y. Takahashi; M. Nishikawa; H. Shinotsuka; Y. Matsui; S. Ohara; T. Imai; Y. Takakura Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection Journal of Biotechnology, 165, 2, 77-84 Journal of Biotechnology, 165, 2, 77-84 Journal of Biotechnology, 165, 2, 77-84 2013/05 英語 公開
K. Kusamori; M. Nishikawa; Y. Takahashi; Y. Takakura K. Kusamori; M. Nishikawa; Y. Takahashi; Y. Takakura Development of multicellular spheroid for cell-based therapy Development of multicellular spheroid for cell-based therapy Drug Delivery System, 28, 1, 45-53 Drug Delivery System, 28, 1, 45-53 , 28, 1, 45-53 2013 日本語 公開
K. Watcharanurak; M. Nishikawa; Y. Takahashi; K. Kabashima; R. Takahashi; Y. Takakura K. Watcharanurak; M. Nishikawa; Y. Takahashi; K. Kabashima; R. Takahashi; Y. Takakura K. Watcharanurak; M. Nishikawa; Y. Takahashi; K. Kabashima; R. Takahashi; Y. Takakura Regulation of immunological balance by sustained interferon-γ gene transfer for acute phase of atopic dermatitis in mice Regulation of immunological balance by sustained interferon-γ gene transfer for acute phase of atopic dermatitis in mice Regulation of immunological balance by sustained interferon-γ gene transfer for acute phase of atopic dermatitis in mice Gene Therapy, 20, 5, 538-544 Gene Therapy, 20, 5, 538-544 Gene Therapy, 20, 5, 538-544 2013 英語 公開
K. Mohri; N. Takahashi; M. Nishikawa; E. Kusuki; T. Shiomi; Y. Takahashi; Y. Takakura K. Mohri; N. Takahashi; M. Nishikawa; E. Kusuki; T. Shiomi; Y. Takahashi; Y. Takakura K. Mohri; N. Takahashi; M. Nishikawa; E. Kusuki; T. Shiomi; Y. Takahashi; Y. Takakura Increased immunostimulatory activity of polypod-like structured DNA by ligation of the terminal loop structures Increased immunostimulatory activity of polypod-like structured DNA by ligation of the terminal loop structures Increased immunostimulatory activity of polypod-like structured DNA by ligation of the terminal loop structures Journal of Controlled Release, 163, 3, 285-292 Journal of Controlled Release, 163, 3, 285-292 Journal of Controlled Release, 163, 3, 285-292 2012/11 英語 公開
K. Watcharanurak; M. Nishikawa; Y. Takahashi; Y. Takakura K. Watcharanurak; M. Nishikawa; Y. Takahashi; Y. Takakura K. Watcharanurak; M. Nishikawa; Y. Takahashi; Y. Takakura Controlling the kinetics of interferon transgene expression for improved gene therapy Controlling the kinetics of interferon transgene expression for improved gene therapy Controlling the kinetics of interferon transgene expression for improved gene therapy Journal of Drug Targeting, 20, 9, 764-769 Journal of Drug Targeting, 20, 9, 764-769 Journal of Drug Targeting, 20, 9, 764-769 2012/11 英語 公開
H. Yoshida; M. Nishikawa; S. Yasuda; H. Toyota; T. Kiyota; Y. Takahashi; Y. Takakura H. Yoshida; M. Nishikawa; S. Yasuda; H. Toyota; T. Kiyota; Y. Takahashi; Y. Takakura H. Yoshida; M. Nishikawa; S. Yasuda; H. Toyota; T. Kiyota; Y. Takahashi; Y. Takakura Fibronectin inhibits cytokine production induced by CpG DNA in macrophages without direct binding to DNA Fibronectin inhibits cytokine production induced by CpG DNA in macrophages without direct binding to DNA Fibronectin inhibits cytokine production induced by CpG DNA in macrophages without direct binding to DNA Cytokine, 60, 1, 162-170 Cytokine, 60, 1, 162-170 Cytokine, 60, 1, 162-170 2012/10 英語 公開
S. Rattanakiat; M. Nishikawa; Y. Takakura S. Rattanakiat; M. Nishikawa; Y. Takakura S. Rattanakiat; M. Nishikawa; Y. Takakura Self-assembling CpG DNA nanoparticles for efficient antigen delivery and immunostimulation Self-assembling CpG DNA nanoparticles for efficient antigen delivery and immunostimulation Self-assembling CpG DNA nanoparticles for efficient antigen delivery and immunostimulation European Journal of Pharmaceutical Sciences, 47, 2, 352-358 European Journal of Pharmaceutical Sciences, 47, 2, 352-358 European Journal of Pharmaceutical Sciences, 47, 2, 352-358 2012/09 英語 公開
K. Mohri; M. Nishikawa; N. Takahashi; T. Shiomi; N. Matsuoka; K. Ogawa; M. Endo; K. Hidaka; H. Sugiyama; Y. Takahashi; Y. Takakura K. Mohri; M. Nishikawa; N. Takahashi; T. Shiomi; N. Matsuoka; K. Ogawa; M. Endo; K. Hidaka; H. Sugiyama; Y. Takahashi; Y. Takakura K. Mohri; M. Nishikawa; N. Takahashi; T. Shiomi; N. Matsuoka; K. Ogawa; M. Endo; K. Hidaka; H. Sugiyama; Y. Takahashi; Y. Takakura Design and development of nanosized DNA assemblies in polypod-like structures as efficient vehicles for immunostimulatory cpg motifs to immune cells Design and development of nanosized DNA assemblies in polypod-like structures as efficient vehicles for immunostimulatory cpg motifs to immune cells Design and development of nanosized DNA assemblies in polypod-like structures as efficient vehicles for immunostimulatory cpg motifs to immune cells ACS Nano, 6, 7, 5931-5940 ACS Nano, 6, 7, 5931-5940 ACS Nano, 6, 7, 5931-5940 2012/07 英語 公開
D. Oushiki; H. Kojima; Y. Takahashi; T. Komatsu; T. Terai; K. Hanaoka; M. Nishikawa; Y. Takakura; T. Nagano D. Oushiki; H. Kojima; Y. Takahashi; T. Komatsu; T. Terai; K. Hanaoka; M. Nishikawa; Y. Takakura; T. Nagano D. Oushiki; H. Kojima; Y. Takahashi; T. Komatsu; T. Terai; K. Hanaoka; M. Nishikawa; Y. Takakura; T. Nagano Near-infrared fluorescence probes for enzymes based on binding affinity modulation of squarylium dye scaffold Near-infrared fluorescence probes for enzymes based on binding affinity modulation of squarylium dye scaffold Near-infrared fluorescence probes for enzymes based on binding affinity modulation of squarylium dye scaffold Analytical Chemistry, 84, 10, 4404-4410 Analytical Chemistry, 84, 10, 4404-4410 Analytical Chemistry, 84, 10, 4404-4410 2012/05 英語 公開
M. Ando; Y. Takahashi; M. Nishikawa; Y. Watanabe; Y. Takakura M. Ando; Y. Takahashi; M. Nishikawa; Y. Watanabe; Y. Takakura M. Ando; Y. Takahashi; M. Nishikawa; Y. Watanabe; Y. Takakura Constant and steady transgene expression of interferon-γ by optimization of plasmid construct for safe and effective interferon-γ gene therapy Constant and steady transgene expression of interferon-γ by optimization of plasmid construct for safe and effective interferon-γ gene therapy Constant and steady transgene expression of interferon-γ by optimization of plasmid construct for safe and effective interferon-γ gene therapy Journal of Gene Medicine, 14, 4, 288-295 Journal of Gene Medicine, 14, 4, 288-295 Journal of Gene Medicine, 14, 4, 288-295 2012/04 英語 公開
X. Guan; M. Nishikawa; H. Li; R. Takahashi; Y. Takahashi; Y. Takakura X. Guan; M. Nishikawa; H. Li; R. Takahashi; Y. Takahashi; Y. Takakura X. Guan; M. Nishikawa; H. Li; R. Takahashi; Y. Takahashi; Y. Takakura Comparison of antigen expression from plasmid DNA in tumor-free and antigen-expressing tumor-bearing mice Comparison of antigen expression from plasmid DNA in tumor-free and antigen-expressing tumor-bearing mice Comparison of antigen expression from plasmid DNA in tumor-free and antigen-expressing tumor-bearing mice Human Vaccines and Immunotherapeutics, 8, 2, 194-200 Human Vaccines and Immunotherapeutics, 8, 2, 194-200 Human Vaccines and Immunotherapeutics, 8, 2, 194-200 2012/02 英語 公開
Y. Takahashi; M. Nishikawa; Y. Takakura Y. Takahashi; M. Nishikawa; Y. Takakura Y. Takahashi; M. Nishikawa; Y. Takakura Development of safe and effective nonviral gene therapy by eliminating CpG motifs from plasmid DNA vector Development of safe and effective nonviral gene therapy by eliminating CpG motifs from plasmid DNA vector Development of safe and effective nonviral gene therapy by eliminating CpG motifs from plasmid DNA vector Frontiers in Bioscience - Scholar, 4 S, 1, 133-141 Frontiers in Bioscience - Scholar, 4 S, 1, 133-141 Frontiers in Bioscience - Scholar, 4 S, 1, 133-141 2012/01 英語 公開
X. Guan; M. Nishikawa; H. Li; T. Rei; Y. Takahashi; Y. Takakura X. Guan; M. Nishikawa; H. Li; T. Rei; Y. Takahashi; Y. Takakura X. Guan; M. Nishikawa; H. Li; T. Rei; Y. Takahashi; Y. Takakura Comparison of antigen expression from plasmid DNA in tumor-free and antigen-expressing tumor-bearing mice Comparison of antigen expression from plasmid DNA in tumor-free and antigen-expressing tumor-bearing mice Comparison of antigen expression from plasmid DNA in tumor-free and antigen-expressing tumor-bearing mice Human Vaccines and Immunotherapeutics, 8, 2, 184-190 Human Vaccines and Immunotherapeutics, 8, 2, 184-190 Human Vaccines and Immunotherapeutics, 8, 2, 184-190 2012 英語 公開
M. Ando; Y. Takahashi; M. Nishikawa; Y. Takakura M. Ando; Y. Takahashi; M. Nishikawa; Y. Takakura Ando M, Takahashi Y, Nishikawa M, Takakura Y Control of spatiotemporal distribution of interferon γ by genetically fusing functional peptides Control of spatiotemporal distribution of interferon γ by genetically fusing functional peptides [Control of spatiotemporal distribution of interferon γ by genetically fusing functional peptides]. Yakugaku Zasshi, 132, 12, 1399-1406 Yakugaku Zasshi, 132, 12, 1399-1406 Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 132, 12, 1399-1406 2012 日本語 公開
Y. Takahashi; M. Nishikawa; N. Takiguchi; T. Suehara; Y. Takakura Y. Takahashi; M. Nishikawa; N. Takiguchi; T. Suehara; Y. Takakura Y. Takahashi; M. Nishikawa; N. Takiguchi; T. Suehara; Y. Takakura Saturation of transgene protein synthesis from mRNA in cells producing a large number of transgene mRNA Saturation of transgene protein synthesis from mRNA in cells producing a large number of transgene mRNA Saturation of transgene protein synthesis from mRNA in cells producing a large number of transgene mRNA Biotechnology and Bioengineering, 108, 10, 2380-2389 Biotechnology and Bioengineering, 108, 10, 2380-2389 Biotechnology and Bioengineering, 108, 10, 2380-2389 2011/10 英語 公開
C. Nishizaki; M. Nishikawa; T. Yata; T. Yamada; Y. Takahashi; M. Oku; H. Yurimoto; Y. Sakai; K. Nakanishi; Y. Takakura C. Nishizaki; M. Nishikawa; T. Yata; T. Yamada; Y. Takahashi; M. Oku; H. Yurimoto; Y. Sakai; K. Nakanishi; Y. Takakura C. Nishizaki; M. Nishikawa; T. Yata; T. Yamada; Y. Takahashi; M. Oku; H. Yurimoto; Y. Sakai; K. Nakanishi; Y. Takakura Inhibition of surgical trauma-enhanced peritoneal dissemination of tumor cells by human catalase derivatives in mice Inhibition of surgical trauma-enhanced peritoneal dissemination of tumor cells by human catalase derivatives in mice Inhibition of surgical trauma-enhanced peritoneal dissemination of tumor cells by human catalase derivatives in mice Free Radical Biology and Medicine, 51, 3, 773-779 Free Radical Biology and Medicine, 51, 3, 773-779 Free Radical Biology and Medicine, 51, 3, 773-779 2011/08/01 英語 公開
H. Yoshida; M. Nishikawa; T. Kiyota; H. Toyota; Y. Takakura H. Yoshida; M. Nishikawa; T. Kiyota; H. Toyota; Y. Takakura H. Yoshida; M. Nishikawa; T. Kiyota; H. Toyota; Y. Takakura Increase in CpG DNA-induced inflammatory responses by DNA oxidation in macrophages and mice Increase in CpG DNA-induced inflammatory responses by DNA oxidation in macrophages and mice Increase in CpG DNA-induced inflammatory responses by DNA oxidation in macrophages and mice Free Radical Biology and Medicine, 51, 2, 424-431 Free Radical Biology and Medicine, 51, 2, 424-431 Free Radical Biology and Medicine, 51, 2, 424-431 2011/07 英語 公開
N. Miyakawa; M. Nishikawa; Y. Takahashi; M. Ando; M. Misaka; Y. Watanabe; Y. Takakura N. Miyakawa; M. Nishikawa; Y. Takahashi; M. Ando; M. Misaka; Y. Watanabe; Y. Takakura N. Miyakawa; M. Nishikawa; Y. Takahashi; M. Ando; M. Misaka; Y. Watanabe; Y. Takakura Prolonged circulation half-life of interferon γ activity by gene delivery of interferon γ-serum albumin fusion protein in mice Prolonged circulation half-life of interferon γ activity by gene delivery of interferon γ-serum albumin fusion protein in mice Prolonged circulation half-life of interferon γ activity by gene delivery of interferon γ-serum albumin fusion protein in mice Journal of Pharmaceutical Sciences, 100, 6, 2350-2357 Journal of Pharmaceutical Sciences, 100, 6, 2350-2357 Journal of Pharmaceutical Sciences, 100, 6, 2350-2357 2011/06 英語 公開
Y. Takakura Y. Takakura Y. Takakura Nucleic acid drug delivery and targeting Nucleic acid drug delivery and targeting Nucleic acid drug delivery and targeting Pharmaceutical Research, 28, 4, 691-693 Pharmaceutical Research, 28, 4, 691-693 Pharmaceutical Research, 28, 4, 691-693 2011/04 英語 公開
N. Takiguchi; Y. Takahashi; M. Nishikawa; Y. Matsui; Y. Fukuhara; D. Oushiki; K. Kiyose; K. Hanaoka; T. Nagano; Y. Takakura N. Takiguchi; Y. Takahashi; M. Nishikawa; Y. Matsui; Y. Fukuhara; D. Oushiki; K. Kiyose; K. Hanaoka; T. Nagano; Y. Takakura N. Takiguchi; Y. Takahashi; M. Nishikawa; Y. Matsui; Y. Fukuhara; D. Oushiki; K. Kiyose; K. Hanaoka; T. Nagano; Y. Takakura Positive correlation between the generation of reactive oxygen species and activation/reactivation of transgene expression after hydrodynamic injections into mice Positive correlation between the generation of reactive oxygen species and activation/reactivation of transgene expression after hydrodynamic injections into mice Positive correlation between the generation of reactive oxygen species and activation/reactivation of transgene expression after hydrodynamic injections into mice Pharmaceutical Research, 28, 4, 702-711 Pharmaceutical Research, 28, 4, 702-711 Pharmaceutical Research, 28, 4, 702-711 2011/04 英語 公開
H. Yoshida; M. Nishikawa; T. Kiyota; S. Uno; H. Toyota; R. Takahashi; M. Narita; Y. Takakura H. Yoshida; M. Nishikawa; T. Kiyota; S. Uno; H. Toyota; R. Takahashi; M. Narita; Y. Takakura H. Yoshida; M. Nishikawa; T. Kiyota; S. Uno; H. Toyota; R. Takahashi; M. Narita; Y. Takakura 5′-Phosphate oligodeoxynucleotides enhance the phosphodiester-CpG DNA-induced inflammatory response in macrophages 5′-Phosphate oligodeoxynucleotides enhance the phosphodiester-CpG DNA-induced inflammatory response in macrophages 5′-Phosphate oligodeoxynucleotides enhance the phosphodiester-CpG DNA-induced inflammatory response in macrophages European Journal of Immunology, 41, 2, 425-436 European Journal of Immunology, 41, 2, 425-436 European Journal of Immunology, 41, 2, 425-436 2011/02 英語 公開
M. Nishikawa; Y. Mizuno; K. Mohri; N. Matsuoka; S. Rattanakiat; Y. Takahashi; H. Funabashi; D. Luo; Y. Takakura M. Nishikawa; Y. Mizuno; K. Mohri; N. Matsuoka; S. Rattanakiat; Y. Takahashi; H. Funabashi; D. Luo; Y. Takakura M. Nishikawa; Y. Mizuno; K. Mohri; N. Matsuoka; S. Rattanakiat; Y. Takahashi; H. Funabashi; D. Luo; Y. Takakura Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice Biomaterials, 32, 2, 488-494 Biomaterials, 32, 2, 488-494 Biomaterials, 32, 2, 488-494 2011/01 英語 公開
L. Zang; M. Nishikawa; K. MacHida; M. Ando; Y. Takahashi; Y. Watanabe; Y. Takakura L. Zang; M. Nishikawa; K. MacHida; M. Ando; Y. Takahashi; Y. Watanabe; Y. Takakura L. Zang; M. Nishikawa; K. MacHida; M. Ando; Y. Takahashi; Y. Watanabe; Y. Takakura Inhibition of nuclear delivery of plasmid DNA and transcription by interferon γ: hurdles to be overcome for sustained gene therapy Inhibition of nuclear delivery of plasmid DNA and transcription by interferon γ: hurdles to be overcome for sustained gene therapy Inhibition of nuclear delivery of plasmid DNA and transcription by interferon γ: hurdles to be overcome for sustained gene therapy Gene Therapy, 18, 9, 891-897 Gene Therapy, 18, 9, 891-897 Gene Therapy, 18, 9, 891-897 2011 英語 公開
M. Nishikawa; Y. Takahashi; Y. Takakura M. Nishikawa; Y. Takahashi; Y. Takakura Nishikawa M, Takahashi Y, Takakura Y Optimization of gene therapy effect by spaciotemporal control of expressed proteins Optimization of gene therapy effect by spaciotemporal control of expressed proteins [Optimization of gene therapy effect by spaciotemporal control of expressed proteins]. Yakugaku Zasshi, 130, 11, 1505-1511 Yakugaku Zasshi, 130, 11, 1505-1511 Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 130, 11, 1505-1511 2010/11 日本語 公開
Takahashi Y, Vikman E, Nishikawa M, Ando M, Watanabe Y, Takakura Y Takahashi Y, Vikman E, Nishikawa M, Ando M, Watanabe Y, Takakura Y Takahashi Y, Vikman E, Nishikawa M, Ando M, Watanabe Y, Takakura Y Persistent interferon transgene expression by RNA interference-mediated silencing of interferon receptors. Persistent interferon transgene expression by RNA interference-mediated silencing of interferon receptors. Persistent interferon transgene expression by RNA interference-mediated silencing of interferon receptors. The journal of gene medicine, 12, 9, 739-746 The journal of gene medicine, 12, 9, 739-746 The journal of gene medicine, 12, 9, 739-746 2010/09 英語 公開
K. Hattori; M. Nishikawa; K. Watcharanurak; A. Ikoma; K. Kabashima; H. Toyota; Y. Takahashi; R. Takahashi; Y. Watanabe; Y. Takakura K. Hattori; M. Nishikawa; K. Watcharanurak; A. Ikoma; K. Kabashima; H. Toyota; Y. Takahashi; R. Takahashi; Y. Watanabe; Y. Takakura K. Hattori; M. Nishikawa; K. Watcharanurak; A. Ikoma; K. Kabashima; H. Toyota; Y. Takahashi; R. Takahashi; Y. Watanabe; Y. Takakura Sustained exogenous expression of therapeutic levels of IFN-γ ameliorates atopic dermatitis in NC/Nga mice via Th1 polarization Sustained exogenous expression of therapeutic levels of IFN-γ ameliorates atopic dermatitis in NC/Nga mice via Th1 polarization Sustained exogenous expression of therapeutic levels of IFN-γ ameliorates atopic dermatitis in NC/Nga mice via Th1 polarization Journal of Immunology, 184, 5, 2729-2735 Journal of Immunology, 184, 5, 2729-2735 Journal of Immunology, 184, 5, 2729-2735 2010/03/01 英語 公開
M. Nishikawa; T. Otsuki; A. Ota; X. Guan; S. Takemoto; Y. Takahashi; Y. Takakura M. Nishikawa; T. Otsuki; A. Ota; X. Guan; S. Takemoto; Y. Takahashi; Y. Takakura M. Nishikawa; T. Otsuki; A. Ota; X. Guan; S. Takemoto; Y. Takahashi; Y. Takakura Induction of tumor-specific immune response by gene transfer of Hsp70-cell-penetrating peptide fusion protein to tumors in mice Induction of tumor-specific immune response by gene transfer of Hsp70-cell-penetrating peptide fusion protein to tumors in mice Induction of tumor-specific immune response by gene transfer of Hsp70-cell-penetrating peptide fusion protein to tumors in mice Molecular Therapy, 18, 2, 421-428 Molecular Therapy, 18, 2, 421-428 Molecular Therapy, 18, 2, 421-428 2010/02 英語 公開
Y. Mizuno; T. Naoi; M. Nishikawa; S. Rattanakiat; N. Hamaguchi; M. Hashida; Y. Takakura Y. Mizuno; T. Naoi; M. Nishikawa; S. Rattanakiat; N. Hamaguchi; M. Hashida; Y. Takakura Y. Mizuno; T. Naoi; M. Nishikawa; S. Rattanakiat; N. Hamaguchi; M. Hashida; Y. Takakura Simultaneous delivery of doxorubicin and immunostimulatory CpG motif to tumors using a plasmid DNA/doxorubicin complex in mice Simultaneous delivery of doxorubicin and immunostimulatory CpG motif to tumors using a plasmid DNA/doxorubicin complex in mice Simultaneous delivery of doxorubicin and immunostimulatory CpG motif to tumors using a plasmid DNA/doxorubicin complex in mice Journal of Controlled Release, 141, 2, 252-259 Journal of Controlled Release, 141, 2, 252-259 Journal of Controlled Release, 141, 2, 252-259 2010 英語 公開
X. Guan; M. Nishikawa; S. Takemoto; Y. Ohno; T. Yata; Y. Takakura X. Guan; M. Nishikawa; S. Takemoto; Y. Ohno; T. Yata; Y. Takakura X. Guan; M. Nishikawa; S. Takemoto; Y. Ohno; T. Yata; Y. Takakura Injection site-dependent induction of immune response by DNA vaccine: Comparison of skin and spleen as a target for vaccination Injection site-dependent induction of immune response by DNA vaccine: Comparison of skin and spleen as a target for vaccination Injection site-dependent induction of immune response by DNA vaccine: Comparison of skin and spleen as a target for vaccination Journal of Gene Medicine, 12, 3, 301-309 Journal of Gene Medicine, 12, 3, 301-309 Journal of Gene Medicine, 12, 3, 301-309 2010 英語 公開
S. Takemoto; K. Yamaoka; M. Nishikawa; Y. Yano; Y. Takakura S. Takemoto; K. Yamaoka; M. Nishikawa; Y. Yano; Y. Takakura S. Takemoto; K. Yamaoka; M. Nishikawa; Y. Yano; Y. Takakura Bootstrap method-based estimation of the minimum sample number for obtaining pharmacokinetic parameters in preclinical experiments Bootstrap method-based estimation of the minimum sample number for obtaining pharmacokinetic parameters in preclinical experiments Bootstrap method-based estimation of the minimum sample number for obtaining pharmacokinetic parameters in preclinical experiments Journal of Pharmaceutical Sciences, 99, 4, 2176-2184 Journal of Pharmaceutical Sciences, 99, 4, 2176-2184 Journal of Pharmaceutical Sciences, 99, 4, 2176-2184 2010 英語 公開
S. Yasuda; H. Yoshida; M. Nishikawa; Y. Takakura S. Yasuda; H. Yoshida; M. Nishikawa; Y. Takakura S. Yasuda; H. Yoshida; M. Nishikawa; Y. Takakura Comparison of the type of liposome involving cytokine production induced by non-cpG lipoplex in macrophages Comparison of the type of liposome involving cytokine production induced by non-cpG lipoplex in macrophages Comparison of the type of liposome involving cytokine production induced by non-cpG lipoplex in macrophages Molecular Pharmaceutics, 7, 2, 533-542 Molecular Pharmaceutics, 7, 2, 533-542 Molecular Pharmaceutics, 7, 2, 533-542 2010 英語 公開
M. Nishikawa; S. Rattanakiat; Y. Takakura M. Nishikawa; S. Rattanakiat; Y. Takakura M. Nishikawa; S. Rattanakiat; Y. Takakura DNA-based nano-sized systems for pharmaceutical and biomedical applications DNA-based nano-sized systems for pharmaceutical and biomedical applications DNA-based nano-sized systems for pharmaceutical and biomedical applications Advanced Drug Delivery Reviews, 62, 6, 626-632 Advanced Drug Delivery Reviews, 62, 6, 626-632 Advanced Drug Delivery Reviews, 62, 6, 626-632 2010 英語 公開
S. Takemoto; M. Nishikawa; X. Guan; Y. Ohno; T. Yata; Y. Takakura S. Takemoto; M. Nishikawa; X. Guan; Y. Ohno; T. Yata; Y. Takakura S. Takemoto; M. Nishikawa; X. Guan; Y. Ohno; T. Yata; Y. Takakura Enhanced generation of cytotoxic T lymphocytes by heat shock protein 70 fusion proteins harboring both CD8<sup>+</sup> T cell and CD4<sup>+</sup> T cell epitopes Enhanced generation of cytotoxic T lymphocytes by heat shock protein 70 fusion proteins harboring both CD8<sup>+</sup> T cell and CD4<sup>+</sup> T cell epitopes Enhanced generation of cytotoxic T lymphocytes by heat shock protein 70 fusion proteins harboring both CD8<sup>+</sup> T cell and CD4<sup>+</sup> T cell epitopes Molecular Pharmaceutics, 7, 5, 1715-1723 Molecular Pharmaceutics, 7, 5, 1715-1723 Molecular Pharmaceutics, 7, 5, 1715-1723 2010 英語 公開
N. Matsuoka; M. Nishikawa; K. Mohri; S. Rattanakiat; Y. Takakura N. Matsuoka; M. Nishikawa; K. Mohri; S. Rattanakiat; Y. Takakura N. Matsuoka; M. Nishikawa; K. Mohri; S. Rattanakiat; Y. Takakura Structural and immunostimulatory properties of Y-shaped DNA consisting of phosphodiester and phosphorothioate oligodeoxynucleotides Structural and immunostimulatory properties of Y-shaped DNA consisting of phosphodiester and phosphorothioate oligodeoxynucleotides Structural and immunostimulatory properties of Y-shaped DNA consisting of phosphodiester and phosphorothioate oligodeoxynucleotides Journal of Controlled Release, 148, 3, 311-316 Journal of Controlled Release, 148, 3, 311-316 Journal of Controlled Release, 148, 3, 311-316 2010 英語 公開
K. Mohri; M. Nishikawa; Y. Takahaski; Y. Takakura K. Mohri; M. Nishikawa; Y. Takahaski; Y. Takakura K. Mohri; M. Nishikawa; Y. Takahaski; Y. Takakura Development of oligonucleotide-based nano-sized DDS Development of oligonucleotide-based nano-sized DDS Development of oligonucleotide-based nano-sized DDS Drug Delivery System, 25, 6, 573-578 Drug Delivery System, 25, 6, 573-578 Drug Delivery System, 25, 6, 573-578 2010 英語 公開
T. Yata; M. Nishikawa; C. Nishizaki; M. Oku; H. Yurimoto; Y. Sakai; Y. Takakura T. Yata; M. Nishikawa; C. Nishizaki; M. Oku; H. Yurimoto; Y. Sakai; Y. Takakura T. Yata; M. Nishikawa; C. Nishizaki; M. Oku; H. Yurimoto; Y. Sakai; Y. Takakura Control of hypoxia-induced tumor cell adhesion by cytophilic human catalase Control of hypoxia-induced tumor cell adhesion by cytophilic human catalase Control of hypoxia-induced tumor cell adhesion by cytophilic human catalase Free Radical Biology and Medicine, 47, 12, 1772-1778 Free Radical Biology and Medicine, 47, 12, 1772-1778 Free Radical Biology and Medicine, 47, 12, 1772-1778 2009/12/15 英語 公開
Y. Takahashi; M. Nishikawa; Y. Takakura Y. Takahashi; M. Nishikawa; Y. Takakura Y. Takahashi; M. Nishikawa; Y. Takakura Nonviral vector-mediated RNA interference: Its gene silencing characteristics and important factors to achieve RNAi-based gene therapy Nonviral vector-mediated RNA interference: Its gene silencing characteristics and important factors to achieve RNAi-based gene therapy Nonviral vector-mediated RNA interference: Its gene silencing characteristics and important factors to achieve RNAi-based gene therapy Advanced Drug Delivery Reviews, 61, 9, 760-766 Advanced Drug Delivery Reviews, 61, 9, 760-766 Advanced Drug Delivery Reviews, 61, 9, 760-766 2009/07/25 英語 公開
M. Mitsui; M. Nishikawa; L. Zang; M. Ando; K. Hattori; Y. Takahashi; Y. Watanabe; Y. Takakura M. Mitsui; M. Nishikawa; L. Zang; M. Ando; K. Hattori; Y. Takahashi; Y. Watanabe; Y. Takakura M. Mitsui; M. Nishikawa; L. Zang; M. Ando; K. Hattori; Y. Takahashi; Y. Watanabe; Y. Takakura Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression. Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression. Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression. The journal of gene medicine, 11, 5, 435-443 The journal of gene medicine, 11, 5, 435-443 The journal of gene medicine, 11, 5, 435-443 2009/05 英語 公開
Y. Takahashi; K. Yamaoka; M. Nishikawa; Y. Takakura Y. Takahashi; K. Yamaoka; M. Nishikawa; Y. Takakura Y. Takahashi; K. Yamaoka; M. Nishikawa; Y. Takakura Quantitative and temporal analysis of gene silencing in tumor cells induced by small interfering RNA or short hairpin RNA expressed from plasmid vectors Quantitative and temporal analysis of gene silencing in tumor cells induced by small interfering RNA or short hairpin RNA expressed from plasmid vectors Quantitative and temporal analysis of gene silencing in tumor cells induced by small interfering RNA or short hairpin RNA expressed from plasmid vectors Journal of Pharmaceutical Sciences, 98, 1, 74-80 Journal of Pharmaceutical Sciences, 98, 1, 74-80 Journal of Pharmaceutical Sciences, 98, 1, 74-80 2009/01 英語 公開
S. Takemoto; M. Nishikawa; T. Otsuki; A. Yamaoka; K. Maeda; A. Ota; Y. Takakura S. Takemoto; M. Nishikawa; T. Otsuki; A. Yamaoka; K. Maeda; A. Ota; Y. Takakura S. Takemoto; M. Nishikawa; T. Otsuki; A. Yamaoka; K. Maeda; A. Ota; Y. Takakura Enhanced generation of cytotoxic T lymphocytes by increased cytosolic delivery of MHC class I epitope fused to mouse heat shock protein 70 via polyhistidine conjugation Enhanced generation of cytotoxic T lymphocytes by increased cytosolic delivery of MHC class I epitope fused to mouse heat shock protein 70 via polyhistidine conjugation Enhanced generation of cytotoxic T lymphocytes by increased cytosolic delivery of MHC class I epitope fused to mouse heat shock protein 70 via polyhistidine conjugation Journal of Controlled Release, 135, 1, 11-18 Journal of Controlled Release, 135, 1, 11-18 Journal of Controlled Release, 135, 1, 11-18 2009 英語 公開
K. Isaji; A. Kawase; M. Matono; X. Guan; M. Nishikawa; Y. Takakura K. Isaji; A. Kawase; M. Matono; X. Guan; M. Nishikawa; Y. Takakura K. Isaji; A. Kawase; M. Matono; X. Guan; M. Nishikawa; Y. Takakura Enhanced CTL response by controlled intracellular trafficking of antigen in dendritic cells following DNA vaccination Enhanced CTL response by controlled intracellular trafficking of antigen in dendritic cells following DNA vaccination Enhanced CTL response by controlled intracellular trafficking of antigen in dendritic cells following DNA vaccination Journal of Controlled Release, 135, 3, 227-233 Journal of Controlled Release, 135, 3, 227-233 Journal of Controlled Release, 135, 3, 227-233 2009 英語 公開
M. Nishikawa; M. Hashida; Y. Takakura M. Nishikawa; M. Hashida; Y. Takakura M. Nishikawa; M. Hashida; Y. Takakura Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis Advanced Drug Delivery Reviews, 61, 4, 319-326 Advanced Drug Delivery Reviews, 61, 4, 319-326 Advanced Drug Delivery Reviews, 61, 4, 319-326 2009 英語 公開
Y. Takakura Y. Takakura Y. Takakura Towards therapeutic application of RNA-mediated gene regulation Towards therapeutic application of RNA-mediated gene regulation Towards therapeutic application of RNA-mediated gene regulation Advanced Drug Delivery Reviews, 61, 9, 667 Advanced Drug Delivery Reviews, 61, 9, 667 Advanced Drug Delivery Reviews, 61, 9, 667 2009 英語 公開
M. Maruyama; K. Ishida; Y. Watanabe; M. Nishikawa; Y. Takakura M. Maruyama; K. Ishida; Y. Watanabe; M. Nishikawa; Y. Takakura M. Maruyama; K. Ishida; Y. Watanabe; M. Nishikawa; Y. Takakura Effects of methyl-β-cyclodextrin treatment on secretion profile of interferon-/? and zonula occuludin-1 architecture in madin-darby canine kidney cell monolayers Effects of methyl-β-cyclodextrin treatment on secretion profile of interferon-/? and zonula occuludin-1 architecture in madin-darby canine kidney cell monolayers Effects of methyl-β-cyclodextrin treatment on secretion profile of interferon-/? and zonula occuludin-1 architecture in madin-darby canine kidney cell monolayers Biological and Pharmaceutical Bulletin, 32, 5, 910-915 Biological and Pharmaceutical Bulletin, 32, 5, 910-915 Biological and Pharmaceutical Bulletin, 32, 5, 910-915 2009 英語 公開
S. Rattanakiat; M. Nishikawa; H. Funabashi; D. Luo; Y. Takakura S. Rattanakiat; M. Nishikawa; H. Funabashi; D. Luo; Y. Takakura S. Rattanakiat; M. Nishikawa; H. Funabashi; D. Luo; Y. Takakura The assembly of a short linear natural cytosine-phosphate-guanine DNA into dendritic structures and its effect on immunostimulatory activity The assembly of a short linear natural cytosine-phosphate-guanine DNA into dendritic structures and its effect on immunostimulatory activity The assembly of a short linear natural cytosine-phosphate-guanine DNA into dendritic structures and its effect on immunostimulatory activity Biomaterials, 30, 29, 5701-5706 Biomaterials, 30, 29, 5701-5706 Biomaterials, 30, 29, 5701-5706 2009 英語 公開
H. Yoshida; M. Nishikawa; S. Yasuda; Y. Mizuno; H. Toyota; T. Kiyota; R. Takahashi; Y. Takakura H. Yoshida; M. Nishikawa; S. Yasuda; Y. Mizuno; H. Toyota; T. Kiyota; R. Takahashi; Y. Takakura H. Yoshida; M. Nishikawa; S. Yasuda; Y. Mizuno; H. Toyota; T. Kiyota; R. Takahashi; Y. Takakura TLR9-dependent systemic interferon-β production by intravenous injection of plasmid DNA/cationic liposome complex in mice TLR9-dependent systemic interferon-β production by intravenous injection of plasmid DNA/cationic liposome complex in mice TLR9-dependent systemic interferon-β production by intravenous injection of plasmid DNA/cationic liposome complex in mice Journal of Gene Medicine, 11, 8, 708-717 Journal of Gene Medicine, 11, 8, 708-717 Journal of Gene Medicine, 11, 8, 708-717 2009 英語 公開
Y. Takahashi; M. Nishikawa; T. Suehara; N. Takiguchi; Y. Takakura Y. Takahashi; M. Nishikawa; T. Suehara; N. Takiguchi; Y. Takakura Y. Takahashi; M. Nishikawa; T. Suehara; N. Takiguchi; Y. Takakura Gene silencing of β-catenin in melanoma cells retards their growth but promotes the formation of pulmonary metastasis in mice Gene silencing of β-catenin in melanoma cells retards their growth but promotes the formation of pulmonary metastasis in mice Gene silencing of β-catenin in melanoma cells retards their growth but promotes the formation of pulmonary metastasis in mice International Journal of Cancer, 123, 10, 2315-2320 International Journal of Cancer, 123, 10, 2315-2320 International Journal of Cancer, 123, 10, 2315-2320 2008/11/15 英語 公開
M. Nishikawa; A. Nakayama; Y. Takahashi; Y. Fukuhara; Y. Takakura M. Nishikawa; A. Nakayama; Y. Takahashi; Y. Fukuhara; Y. Takakura M. Nishikawa; A. Nakayama; Y. Takahashi; Y. Fukuhara; Y. Takakura Reactivation of silenced transgene expression in mouse liver by rapid, large-volume injection of isotonic solution Reactivation of silenced transgene expression in mouse liver by rapid, large-volume injection of isotonic solution Reactivation of silenced transgene expression in mouse liver by rapid, large-volume injection of isotonic solution Human Gene Therapy, 19, 10, 1009-1020 Human Gene Therapy, 19, 10, 1009-1020 Human Gene Therapy, 19, 10, 1009-1020 2008/10 英語 公開
Y. Takahashi; H. Kaneda; N. Takasuka; K. Hattori; M. Nishikawa; Y. Takakura Y. Takahashi; H. Kaneda; N. Takasuka; K. Hattori; M. Nishikawa; Y. Takakura Y. Takahashi; H. Kaneda; N. Takasuka; K. Hattori; M. Nishikawa; Y. Takakura Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells Cancer Science, 99, 8, 1650-1655 Cancer Science, 99, 8, 1650-1655 Cancer Science, 99, 8, 1650-1655 2008/08 英語 公開
Nishikawa M, Matono M, Rattanakiat S, Matsuoka N, Takakura Y Nishikawa M, Matono M, Rattanakiat S, Matsuoka N, Takakura Y Nishikawa M, Matono M, Rattanakiat S, Matsuoka N, Takakura Y Enhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape formation. Enhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape formation. Enhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape formation. Immunology, 124, 2, 247-255 Immunology, 124, 2, 247-255 Immunology, 124, 2, 247-255 2008/06 英語 公開
Nishikawa M, Takakura Y, Hashida M Nishikawa M, Takakura Y, Hashida M Nishikawa M, Takakura Y, Hashida M Pharmacokinetic considerations regarding non-viral cancer gene therapy. Pharmacokinetic considerations regarding non-viral cancer gene therapy. Pharmacokinetic considerations regarding non-viral cancer gene therapy. Cancer science, 99, 5, 856-862 Cancer science, 99, 5, 856-862 Cancer science, 99, 5, 856-862 2008/05 英語 公開
Y. Takahashi; M. Nishikawa; Y. Takakura Y. Takahashi; M. Nishikawa; Y. Takakura Y. Takahashi; M. Nishikawa; Y. Takakura Inhibition of tumor cell growth in the liver by RNA interference-mediated suppression of HIF-1α expression in tumor cells and hepatocytes Inhibition of tumor cell growth in the liver by RNA interference-mediated suppression of HIF-1α expression in tumor cells and hepatocytes Inhibition of tumor cell growth in the liver by RNA interference-mediated suppression of HIF-1α expression in tumor cells and hepatocytes Gene Therapy, 15, 8, 572-582 Gene Therapy, 15, 8, 572-582 Gene Therapy, 15, 8, 572-582 2008/04 英語 公開
Nishikawa M, Takemoto S, Takakura Y Nishikawa M, Takemoto S, Takakura Y Nishikawa M, Takemoto S, Takakura Y Heat shock protein derivatives for delivery of antigens to antigen presenting cells. Heat shock protein derivatives for delivery of antigens to antigen presenting cells. Heat shock protein derivatives for delivery of antigens to antigen presenting cells. International journal of pharmaceutics, 354, 1-2, 23-27 International journal of pharmaceutics, 354, 1-2, 23-27 International journal of pharmaceutics, 354, 1-2, 23-27 2008/04 英語 公開
Y. Ogawa; T. Yoshinaga; M. Nishikawa; Y. Takakura Y. Ogawa; T. Yoshinaga; M. Nishikawa; Y. Takakura Y. Ogawa; T. Yoshinaga; M. Nishikawa; Y. Takakura Unique cytokine production profile following stimulation with DNA in macrophages from NZB/W F<sub>1</sub> mice Unique cytokine production profile following stimulation with DNA in macrophages from NZB/W F<sub>1</sub> mice Unique cytokine production profile following stimulation with DNA in macrophages from NZB/W F<sub>1</sub> mice Biological and Pharmaceutical Bulletin, 31, 6, 1244-1249 Biological and Pharmaceutical Bulletin, 31, 6, 1244-1249 Biological and Pharmaceutical Bulletin, 31, 6, 1244-1249 2008 英語 公開
K. Kako; M. Nishikawa; H. Yoshida; Y. Takakura K. Kako; M. Nishikawa; H. Yoshida; Y. Takakura K. Kako; M. Nishikawa; H. Yoshida; Y. Takakura Effects of inflammatory response on in vivo transgene expression by plasmid DNA in Mice Effects of inflammatory response on in vivo transgene expression by plasmid DNA in Mice Effects of inflammatory response on in vivo transgene expression by plasmid DNA in Mice Journal of Pharmaceutical Sciences, 97, 8, 3074-3083 Journal of Pharmaceutical Sciences, 97, 8, 3074-3083 Journal of Pharmaceutical Sciences, 97, 8, 3074-3083 2008 英語 公開
Y. Takahashi; H. Kaneda; N. Takasuka; K. Hattori; M. Nishikawa; Y. Watanabe; Y. Takakura Y. Takahashi; H. Kaneda; N. Takasuka; K. Hattori; M. Nishikawa; Y. Watanabe; Y. Takakura Y. Takahashi; H. Kaneda; N. Takasuka; K. Hattori; M. Nishikawa; Y. Watanabe; Y. Takakura Erratum: (Cancer Science (2008) (1650)) Erratum: (Cancer Science (2008) (1650)) Erratum: (Cancer Science (2008) (1650)) Cancer Science, 99, 10, 2106- Cancer Science, 99, 10, 2106- Cancer Science, 99, 10, 2106- 2008 英語 公開
H. Yoshida; M. Nishikawa; S. Yasuda; Y. Mizuno; Y. Takakura H. Yoshida; M. Nishikawa; S. Yasuda; Y. Mizuno; Y. Takakura H. Yoshida; M. Nishikawa; S. Yasuda; Y. Mizuno; Y. Takakura Cellular activation by plasmid dna in various macrophages in primary culture Cellular activation by plasmid dna in various macrophages in primary culture Cellular activation by plasmid dna in various macrophages in primary culture Journal of Pharmaceutical Sciences, 97, 10, 4575-4585 Journal of Pharmaceutical Sciences, 97, 10, 4575-4585 Journal of Pharmaceutical Sciences, 97, 10, 4575-4585 2008 英語 公開
Takahashi Y, Nishikawa M, Takakura Y Takahashi Y, Nishikawa M, Takakura Y Takahashi Y, Nishikawa M, Takakura Y [In vivo siRNA delivery to tumor cells and its application to cancer gene therapy]. [In vivo siRNA delivery to tumor cells and its application to cancer gene therapy]. [In vivo siRNA delivery to tumor cells and its application to cancer gene therapy]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 127, 10, 1525-1531 Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 127, 10, 1525-1531 Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 127, 10, 1525-1531 2007/10 日本語 公開
Hirata K, Nishikawa M, Kobayashi N, Takahashi Y, Takakura Y Hirata K, Nishikawa M, Kobayashi N, Takahashi Y, Takakura Y Hirata K, Nishikawa M, Kobayashi N, Takahashi Y, Takakura Y Design of PCR-amplified DNA fragments for in vivo gene delivery: size-dependency on stability and transgene expression. Design of PCR-amplified DNA fragments for in vivo gene delivery: size-dependency on stability and transgene expression. Design of PCR-amplified DNA fragments for in vivo gene delivery: size-dependency on stability and transgene expression. Journal of pharmaceutical sciences, 96, 9, 2251-2261 Journal of pharmaceutical sciences, 96, 9, 2251-2261 Journal of pharmaceutical sciences, 96, 9, 2251-2261 2007/09 英語 公開
Y. Takakura; S. Takemoto; M. Nishikawa Y. Takakura; S. Takemoto; M. Nishikawa Y. Takakura; S. Takemoto; M. Nishikawa Hsp-based tumor vaccines: State-of-the-art and future directions Hsp-based tumor vaccines: State-of-the-art and future directions Hsp-based tumor vaccines: State-of-the-art and future directions Current Opinion in Molecular Therapeutics, 9, 4, 385-391 Current Opinion in Molecular Therapeutics, 9, 4, 385-391 Current Opinion in Molecular Therapeutics, 9, 4, 385-391 2007/08 英語 公開
H. Kawano; M. Nishikawa; M. Mitsui; Y. Takahashi; K. Kako; K. Yamaoka; Y. Watanabe; Y. Takakura H. Kawano; M. Nishikawa; M. Mitsui; Y. Takahashi; K. Kako; K. Yamaoka; Y. Watanabe; Y. Takakura H. Kawano; M. Nishikawa; M. Mitsui; Y. Takahashi; K. Kako; K. Yamaoka; Y. Watanabe; Y. Takakura Improved anti-cancer effect of interferon gene transfer by sustained expression using CpG-reduced plasmid DNA Improved anti-cancer effect of interferon gene transfer by sustained expression using CpG-reduced plasmid DNA Improved anti-cancer effect of interferon gene transfer by sustained expression using CpG-reduced plasmid DNA International Journal of Cancer, 121, 2, 401-406 International Journal of Cancer, 121, 2, 401-406 International Journal of Cancer, 121, 2, 401-406 2007/07/15 英語 公開
Takagi A, Yamashita N, Yoshioka T, Takaishi Y, Sano K, Yamaguchi H, Maeda A, Saito K, Takakura Y, Hashida M Takagi A, Yamashita N, Yoshioka T, Takaishi Y, Sano K, Yamaguchi H, Maeda A, Saito K, Takakura Y, Hashida M Takagi A, Yamashita N, Yoshioka T, Takaishi Y, Sano K, Yamaguchi H, Maeda A, Saito K, Takakura Y, Hashida M Enhanced pharmacological activity of recombinant human interleukin-11 (rhIL11) by chemical modification with polyethylene glycol. Enhanced pharmacological activity of recombinant human interleukin-11 (rhIL11) by chemical modification with polyethylene glycol. Enhanced pharmacological activity of recombinant human interleukin-11 (rhIL11) by chemical modification with polyethylene glycol. Journal of controlled release : official journal of the Controlled Release Society, 119, 3, 271-278 Journal of controlled release : official journal of the Controlled Release Society, 119, 3, 271-278 Journal of controlled release : official journal of the Controlled Release Society, 119, 3, 271-278 2007/06 英語 公開
Fukuhara Y, Naoi T, Ogawa Y, Nishikawa M, Takakura Y Fukuhara Y, Naoi T, Ogawa Y, Nishikawa M, Takakura Y Fukuhara Y, Naoi T, Ogawa Y, Nishikawa M, Takakura Y Plasmid DNA uptake and subsequent cellular activation characteristics in human monocyte-derived cells in primary culture. Plasmid DNA uptake and subsequent cellular activation characteristics in human monocyte-derived cells in primary culture. Plasmid DNA uptake and subsequent cellular activation characteristics in human monocyte-derived cells in primary culture. Journal of pharmaceutical sciences, 96, 6, 1576-1584 Journal of pharmaceutical sciences, 96, 6, 1576-1584 Journal of pharmaceutical sciences, 96, 6, 1576-1584 2007/06 英語 公開
Imura Y, Nishida M, Ogawa Y, Takakura Y, Matsuzaki K Imura Y, Nishida M, Ogawa Y, Takakura Y, Matsuzaki K Imura Y, Nishida M, Ogawa Y, Takakura Y, Matsuzaki K Action mechanism of tachyplesin I and effects of PEGylation. Action mechanism of tachyplesin I and effects of PEGylation. Action mechanism of tachyplesin I and effects of PEGylation. Biochimica et biophysica acta, 1768, 5, 1160-1169 Biochimica et biophysica acta, 1768, 5, 1160-1169 Biochimica et biophysica acta, 1768, 5, 1160-1169 2007/05 英語 公開
Yoshinaga T, Yasuda K, Ogawa Y, Nishikawa M, Takakura Y Yoshinaga T, Yasuda K, Ogawa Y, Nishikawa M, Takakura Y Yoshinaga T, Yasuda K, Ogawa Y, Nishikawa M, Takakura Y DNA and its cationic lipid complexes induce CpG motif-dependent activation of murine dendritic cells. DNA and its cationic lipid complexes induce CpG motif-dependent activation of murine dendritic cells. DNA and its cationic lipid complexes induce CpG motif-dependent activation of murine dendritic cells. Immunology, 120, 3, 295-302 Immunology, 120, 3, 295-302 Immunology, 120, 3, 295-302 2007/03 英語 公開
Nagayama S, Ogawara K, Minato K, Fukuoka Y, Takakura Y, Hashida M, Higaki K, Kimura T Nagayama S, Ogawara K, Minato K, Fukuoka Y, Takakura Y, Hashida M, Higaki K, Kimura T Nagayama S, Ogawara K, Minato K, Fukuoka Y, Takakura Y, Hashida M, Higaki K, Kimura T Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor. Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor. Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor. International journal of pharmaceutics, 329, 1-2, 192-198 International journal of pharmaceutics, 329, 1-2, 192-198 International journal of pharmaceutics, 329, 1-2, 192-198 2007/02 英語 公開
Nishikawa M, Takemoto S, Takakura Y Nishikawa M, Takemoto S, Takakura Y Nishikawa M, Takemoto S, Takakura Y [Development of heat shock proteins with controlled distribution properties and their application to vaccine delivery]. [Development of heat shock proteins with controlled distribution properties and their application to vaccine delivery]. [Development of heat shock proteins with controlled distribution properties and their application to vaccine delivery]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 127, 2, 293-300 Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 127, 2, 293-300 Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 127, 2, 293-300 2007/02 日本語 公開
Yamasaki Y, Ikenaga T, Otsuki T, Nishikawa M, Takakura Y Yamasaki Y, Ikenaga T, Otsuki T, Nishikawa M, Takakura Y Yamasaki Y, Ikenaga T, Otsuki T, Nishikawa M, Takakura Y Induction of antigen-specific cytotoxic T lymphocytes by immunization with negatively charged soluble antigen through scavenger receptor-mediated delivery. Induction of antigen-specific cytotoxic T lymphocytes by immunization with negatively charged soluble antigen through scavenger receptor-mediated delivery. Induction of antigen-specific cytotoxic T lymphocytes by immunization with negatively charged soluble antigen through scavenger receptor-mediated delivery. Vaccine, 25, 1, 85-91 Vaccine, 25, 1, 85-91 Vaccine, 25, 1, 85-91 2007/01 英語 公開
Takemoto S, Yamaoka K, Nishikawa M, Takakura Y Takemoto S, Yamaoka K, Nishikawa M, Takakura Y Takemoto S, Yamaoka K, Nishikawa M, Takakura Y Histogram analysis of pharmacokinetic parameters by bootstrap resampling from one-point sampling data in animal experiments. Histogram analysis of pharmacokinetic parameters by bootstrap resampling from one-point sampling data in animal experiments. Histogram analysis of pharmacokinetic parameters by bootstrap resampling from one-point sampling data in animal experiments. Drug metabolism and pharmacokinetics, 21, 6, 458-464 Drug metabolism and pharmacokinetics, 21, 6, 458-464 Drug metabolism and pharmacokinetics, 21, 6, 458-464 2006/12 英語 公開
Takahashi Y, Nishikawa M, Takakura Y Takahashi Y, Nishikawa M, Takakura Y Takahashi Y, Nishikawa M, Takakura Y Suppression of tumor growth by intratumoral injection of short hairpin RNA-expressing plasmid DNA targeting beta-catenin or hypoxia-inducible factor 1alpha. Suppression of tumor growth by intratumoral injection of short hairpin RNA-expressing plasmid DNA targeting beta-catenin or hypoxia-inducible factor 1alpha. Suppression of tumor growth by intratumoral injection of short hairpin RNA-expressing plasmid DNA targeting beta-catenin or hypoxia-inducible factor 1alpha. Journal of controlled release : official journal of the Controlled Release Society, 116, 1, 90-95 Journal of controlled release : official journal of the Controlled Release Society, 116, 1, 90-95 Journal of controlled release : official journal of the Controlled Release Society, 116, 1, 90-95 2006/11 英語 公開
Takagi A, Yamashita N, Yoshioka T, Takaishi Y, Nakanishi K, Takemura S, Maeda A, Saito K, Takakura Y, Hashida M Takagi A, Yamashita N, Yoshioka T, Takaishi Y, Nakanishi K, Takemura S, Maeda A, Saito K, Takakura Y, Hashida M Takagi A, Yamashita N, Yoshioka T, Takaishi Y, Nakanishi K, Takemura S, Maeda A, Saito K, Takakura Y, Hashida M Incorporation into a biodegradable hyaluronic acid matrix enhances in vivo efficacy of recombinant human interleukin 11 (rhIL11). Incorporation into a biodegradable hyaluronic acid matrix enhances in vivo efficacy of recombinant human interleukin 11 (rhIL11). Incorporation into a biodegradable hyaluronic acid matrix enhances in vivo efficacy of recombinant human interleukin 11 (rhIL11). Journal of controlled release : official journal of the Controlled Release Society, 115, 2, 134-139 Journal of controlled release : official journal of the Controlled Release Society, 115, 2, 134-139 Journal of controlled release : official journal of the Controlled Release Society, 115, 2, 134-139 2006/10 英語 公開
Kawase A, Isaji K, Yamaoka A, Kobayashi N, Nishikawa M, Takakura Y Kawase A, Isaji K, Yamaoka A, Kobayashi N, Nishikawa M, Takakura Y Kawase A, Isaji K, Yamaoka A, Kobayashi N, Nishikawa M, Takakura Y Enhanced antigen-specific antibody production following polyplex-based DNA vaccination via the intradermal route in mice. Enhanced antigen-specific antibody production following polyplex-based DNA vaccination via the intradermal route in mice. Enhanced antigen-specific antibody production following polyplex-based DNA vaccination via the intradermal route in mice. Vaccine, 24, 27-28, 5535-5545 Vaccine, 24, 27-28, 5535-5545 Vaccine, 24, 27-28, 5535-5545 2006/07 英語 公開
Takahashi Y, Yamaoka K, Nishikawa M, Takakura Y Takahashi Y, Yamaoka K, Nishikawa M, Takakura Y Takahashi Y, Yamaoka K, Nishikawa M, Takakura Y Moment analysis for kinetics of gene silencing by RNA interference. Moment analysis for kinetics of gene silencing by RNA interference. Moment analysis for kinetics of gene silencing by RNA interference. Biotechnology and bioengineering, 93, 4, 816-819 Biotechnology and bioengineering, 93, 4, 816-819 Biotechnology and bioengineering, 93, 4, 816-819 2006/03 英語 公開
Yasuda K, Wagner H, Takakura Y Yasuda K, Wagner H, Takakura Y Yasuda K, Wagner H, Takakura Y Role of immunostimulatory DNA and TLR9 in gene therapy. Role of immunostimulatory DNA and TLR9 in gene therapy. Role of immunostimulatory DNA and TLR9 in gene therapy. Critical reviews in therapeutic drug carrier systems, 23, 2, 89-110 Critical reviews in therapeutic drug carrier systems, 23, 2, 89-110 Critical reviews in therapeutic drug carrier systems, 23, 2, 89-110 2006 英語 公開
Takahashi Y, Nishikawa M, Kobayashi N, Takakura Y Takahashi Y, Nishikawa M, Kobayashi N, Takakura Y Takahashi Y, Nishikawa M, Kobayashi N, Takakura Y Gene silencing in primary and metastatic tumors by small interfering RNA delivery in mice: quantitative analysis using melanoma cells expressing firefly and sea pansy luciferases. Gene silencing in primary and metastatic tumors by small interfering RNA delivery in mice: quantitative analysis using melanoma cells expressing firefly and sea pansy luciferases. Gene silencing in primary and metastatic tumors by small interfering RNA delivery in mice: quantitative analysis using melanoma cells expressing firefly and sea pansy luciferases. Journal of controlled release : official journal of the Controlled Release Society, 105, 3, 332-343 Journal of controlled release : official journal of the Controlled Release Society, 105, 3, 332-343 Journal of controlled release : official journal of the Controlled Release Society, 105, 3, 332-343 2005/07 英語 公開
M. Maruyama; M. Kishimoto; K. Ishida; Y. Watanabe; M. Nishikawa; S. Masuda; R. Sasaki; Y. Takakura M. Maruyama; M. Kishimoto; K. Ishida; Y. Watanabe; M. Nishikawa; S. Masuda; R. Sasaki; Y. Takakura M. Maruyama; M. Kishimoto; K. Ishida; Y. Watanabe; M. Nishikawa; S. Masuda; R. Sasaki; Y. Takakura Cholesterol is required for the polarized secretion of erythropoietin in Madin-Darby canine kidney cells Cholesterol is required for the polarized secretion of erythropoietin in Madin-Darby canine kidney cells Cholesterol is required for the polarized secretion of erythropoietin in Madin-Darby canine kidney cells Archives of Biochemistry and Biophysics, 438, 2, 174-181 Archives of Biochemistry and Biophysics, 438, 2, 174-181 Archives of Biochemistry and Biophysics, 438, 2, 174-181 2005/06/15 英語 公開
N. Kobayashi; M. Nishikawa; Y. Takakura N. Kobayashi; M. Nishikawa; Y. Takakura N. Kobayashi; M. Nishikawa; Y. Takakura The hydrodynamics-based procedure for controlling the pharmacokinetics of gene medicines at whole body, organ and cellular levels The hydrodynamics-based procedure for controlling the pharmacokinetics of gene medicines at whole body, organ and cellular levels The hydrodynamics-based procedure for controlling the pharmacokinetics of gene medicines at whole body, organ and cellular levels Advanced Drug Delivery Reviews, 57, 5, 713-731 Advanced Drug Delivery Reviews, 57, 5, 713-731 Advanced Drug Delivery Reviews, 57, 5, 713-731 2005/04 英語 公開
M. Nishikawa; Y. Takakura; M. Hashida M. Nishikawa; Y. Takakura; M. Hashida M. Nishikawa; Y. Takakura; M. Hashida Theoretical considerations involving the pharmacokinetics of plasmid DNA Theoretical considerations involving the pharmacokinetics of plasmid DNA Theoretical considerations involving the pharmacokinetics of plasmid DNA Advanced Drug Delivery Reviews, 57, 5, 675-688 Advanced Drug Delivery Reviews, 57, 5, 675-688 Advanced Drug Delivery Reviews, 57, 5, 675-688 2005/04 英語 公開
A. Kawase; N. Kobayashi; K. Isaji; M. Nishikawa; Y. Takakura A. Kawase; N. Kobayashi; K. Isaji; M. Nishikawa; Y. Takakura A. Kawase; N. Kobayashi; K. Isaji; M. Nishikawa; Y. Takakura Manipulation of local disposition and gene expression characteristics of plasmid DNA following intramuscular administration by complexation with cationic macromolecule Manipulation of local disposition and gene expression characteristics of plasmid DNA following intramuscular administration by complexation with cationic macromolecule Manipulation of local disposition and gene expression characteristics of plasmid DNA following intramuscular administration by complexation with cationic macromolecule International Journal of Pharmaceutics, 293, 1-2, 291-301 International Journal of Pharmaceutics, 293, 1-2, 291-301 International Journal of Pharmaceutics, 293, 1-2, 291-301 2005/04 英語 公開
S. Takemoto; M. Nishikawa; Y. Takakura S. Takemoto; M. Nishikawa; Y. Takakura S. Takemoto; M. Nishikawa; Y. Takakura Pharmacokinetic and tissue distribution mechanism of mouse recombinant heat shock protein 70 in mice Pharmacokinetic and tissue distribution mechanism of mouse recombinant heat shock protein 70 in mice Pharmacokinetic and tissue distribution mechanism of mouse recombinant heat shock protein 70 in mice Pharmaceutical Research, 22, 3, 419-426 Pharmaceutical Research, 22, 3, 419-426 Pharmaceutical Research, 22, 3, 419-426 2005/03 英語 公開
K. Yasuda; Y. Ogawa; I. Yamane; M. Nishikawa; Y. Takakura K. Yasuda; Y. Ogawa; I. Yamane; M. Nishikawa; Y. Takakura K. Yasuda; Y. Ogawa; I. Yamane; M. Nishikawa; Y. Takakura Macrophage activation by a DNA/cationic liposome complex requires endosomal acidification and TLR9-dependent and -independent pathways Macrophage activation by a DNA/cationic liposome complex requires endosomal acidification and TLR9-dependent and -independent pathways Macrophage activation by a DNA/cationic liposome complex requires endosomal acidification and TLR9-dependent and -independent pathways Journal of Leukocyte Biology, 77, 1, 71-79 Journal of Leukocyte Biology, 77, 1, 71-79 Journal of Leukocyte Biology, 77, 1, 71-79 2005/01 英語 公開
Y. Takakura; M. Hashida Y. Takakura; M. Hashida Y. Takakura; M. Hashida Pharmacokinetics in gene delivery Pharmacokinetics in gene delivery Pharmacokinetics in gene delivery Advanced Drug Delivery Reviews, 57, 5, 667-668 Advanced Drug Delivery Reviews, 57, 5, 667-668 Advanced Drug Delivery Reviews, 57, 5, 667-668 2005 英語 公開
Y. Ogawa; T. Yoshinaga; K. Yasuda; M. Nishikawa; Y. Takakura Y. Ogawa; T. Yoshinaga; K. Yasuda; M. Nishikawa; Y. Takakura Y. Ogawa; T. Yoshinaga; K. Yasuda; M. Nishikawa; Y. Takakura The uptake and degradation of DNA is impaired in macrophages and dendritic cells from NZB/W F<sub>1</sub> mice The uptake and degradation of DNA is impaired in macrophages and dendritic cells from NZB/W F<sub>1</sub> mice The uptake and degradation of DNA is impaired in macrophages and dendritic cells from NZB/W F<sub>1</sub> mice Immunology Letters, 101, 1, 32-40 Immunology Letters, 101, 1, 32-40 Immunology Letters, 101, 1, 32-40 2005 英語 公開
I. Yamane; M. Nishikawa; Y. Takakura I. Yamane; M. Nishikawa; Y. Takakura I. Yamane; M. Nishikawa; Y. Takakura Cellular uptake and activation characteristics of naked plasmid DNA and its cationic liposome complex in human macrophages Cellular uptake and activation characteristics of naked plasmid DNA and its cationic liposome complex in human macrophages Cellular uptake and activation characteristics of naked plasmid DNA and its cationic liposome complex in human macrophages International Journal of Pharmaceutics, 305, 1-2, 145-153 International Journal of Pharmaceutics, 305, 1-2, 145-153 International Journal of Pharmaceutics, 305, 1-2, 145-153 2005 英語 公開
M. Nishikawa; K. Hyoudou; Y. Kobayashi; Y. Umeyama; Y. Takakura; M. Hashida M. Nishikawa; K. Hyoudou; Y. Kobayashi; Y. Umeyama; Y. Takakura; M. Hashida M. Nishikawa; K. Hyoudou; Y. Kobayashi; Y. Umeyama; Y. Takakura; M. Hashida Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes Journal of Controlled Release, 109, 1-3, 101-107 Journal of Controlled Release, 109, 1-3, 101-107 Journal of Controlled Release, 109, 1-3, 101-107 2005 英語 公開
Y. Matsui; N. Kobayashi; M. Nishikawa; Y. Takakura Y. Matsui; N. Kobayashi; M. Nishikawa; Y. Takakura Y. Matsui; N. Kobayashi; M. Nishikawa; Y. Takakura Sequence-specific suppression of mdr1a/1b expression in mice via RNA interference Sequence-specific suppression of mdr1a/1b expression in mice via RNA interference Sequence-specific suppression of mdr1a/1b expression in mice via RNA interference Pharmaceutical Research, 22, 12, 2091-2098 Pharmaceutical Research, 22, 12, 2091-2098 Pharmaceutical Research, 22, 12, 2091-2098 2005 英語 公開
M. Nishikawa; Y. Takakura; M. Hashida M. Nishikawa; Y. Takakura; M. Hashida M. Nishikawa; Y. Takakura; M. Hashida Pharmacokinetics of Plasmid DNA-Based Non-viral Gene Medicine Pharmacokinetics of Plasmid DNA-Based Non-viral Gene Medicine Pharmacokinetics of Plasmid DNA-Based Non-viral Gene Medicine Advances in Genetics, 53, 47-68 Advances in Genetics, 53, 47-68 Advances in Genetics, 53, 47-68 2005 英語 公開
N. Kobayashi; M. Nishikawa; Y. Takakura N. Kobayashi; M. Nishikawa; Y. Takakura N. Kobayashi; M. Nishikawa; Y. Takakura Gene Therapy and Gene Delivery Gene Therapy and Gene Delivery Gene Therapy and Gene Delivery Drug Delivery: Principles and Applications, 305-319 Drug Delivery: Principles and Applications, 305-319 Drug Delivery: Principles and Applications, 305-319 2005 英語 公開
H. Kawaguchi; Y. Akazawa; Y. Watanabe; Y. Takakura H. Kawaguchi; Y. Akazawa; Y. Watanabe; Y. Takakura H. Kawaguchi; Y. Akazawa; Y. Watanabe; Y. Takakura Permeability modulation of human intestinal Caco-2 cell monolayers by interferons Permeability modulation of human intestinal Caco-2 cell monolayers by interferons Permeability modulation of human intestinal Caco-2 cell monolayers by interferons European Journal of Pharmaceutics and Biopharmaceutics, 59, 1, 45-50 European Journal of Pharmaceutics and Biopharmaceutics, 59, 1, 45-50 European Journal of Pharmaceutics and Biopharmaceutics, 59, 1, 45-50 2005 英語 公開
N. Kobayashi; Y. Matsui; A. Kawase; K. Hirata; M. Miyagishi; K. Taira; M. Nishikawa; Y. Takakura N. Kobayashi; Y. Matsui; A. Kawase; K. Hirata; M. Miyagishi; K. Taira; M. Nishikawa; Y. Takakura N. Kobayashi; Y. Matsui; A. Kawase; K. Hirata; M. Miyagishi; K. Taira; M. Nishikawa; Y. Takakura Vector-Based in Vivo RNA Interference: Dose- and Time-Dependent Suppression of Transgene Expression Vector-Based in Vivo RNA Interference: Dose- and Time-Dependent Suppression of Transgene Expression Vector-Based in Vivo RNA Interference: Dose- and Time-Dependent Suppression of Transgene Expression Journal of Pharmacology and Experimental Therapeutics, 308, 2, 688-693 Journal of Pharmacology and Experimental Therapeutics, 308, 2, 688-693 Journal of Pharmacology and Experimental Therapeutics, 308, 2, 688-693 2004/02/01 英語 公開
H. Kawaguchi; Y. Matsui; Y. Watanabe; Y. Takakura H. Kawaguchi; Y. Matsui; Y. Watanabe; Y. Takakura H. Kawaguchi; Y. Matsui; Y. Watanabe; Y. Takakura Effect of Interferon-γ on the Pharmacokinetics of Digoxin, a P-glycoprotein Substrate, Intravenously Injected into the Mouse Effect of Interferon-γ on the Pharmacokinetics of Digoxin, a P-glycoprotein Substrate, Intravenously Injected into the Mouse Effect of Interferon-γ on the Pharmacokinetics of Digoxin, a P-glycoprotein Substrate, Intravenously Injected into the Mouse Journal of Pharmacology and Experimental Therapeutics, 308, 1, 91-96 Journal of Pharmacology and Experimental Therapeutics, 308, 1, 91-96 Journal of Pharmacology and Experimental Therapeutics, 308, 1, 91-96 2004 英語 公開
T. Kato; K. Yamaoka; Y. Takakura T. Kato; K. Yamaoka; Y. Takakura T. Kato; K. Yamaoka; Y. Takakura An evaluation method for nonlinear local disposition in rat-liver and kidney An evaluation method for nonlinear local disposition in rat-liver and kidney An evaluation method for nonlinear local disposition in rat-liver and kidney Drug Metabolism and Disposition, 32, 2, 230-234 Drug Metabolism and Disposition, 32, 2, 230-234 Drug Metabolism and Disposition, 32, 2, 230-234 2004 英語 公開
K. Yasuda; H. Kawano; I. Yamane; Y. Ogawa; T. Yoshinaga; M. Nishikawa; Y. Takakura K. Yasuda; H. Kawano; I. Yamane; Y. Ogawa; T. Yoshinaga; M. Nishikawa; Y. Takakura K. Yasuda; H. Kawano; I. Yamane; Y. Ogawa; T. Yoshinaga; M. Nishikawa; Y. Takakura Restricted cytokine production from mouse peritoneal macrophages in culture in spite of extensive uptake of plasmid DNA Restricted cytokine production from mouse peritoneal macrophages in culture in spite of extensive uptake of plasmid DNA Restricted cytokine production from mouse peritoneal macrophages in culture in spite of extensive uptake of plasmid DNA Immunology, 111, 3, 282-290 Immunology, 111, 3, 282-290 Immunology, 111, 3, 282-290 2004 英語 公開
N. Kobayashi; M. Nishikawa; K. Hirata; Y. Takakura N. Kobayashi; M. Nishikawa; K. Hirata; Y. Takakura N. Kobayashi; M. Nishikawa; K. Hirata; Y. Takakura Hydrodynamics-based procedure involves transient hyperpermeability in the hepatic cellular membrane: Implication of a nonspecific process in efficient intracellular gene delivery Hydrodynamics-based procedure involves transient hyperpermeability in the hepatic cellular membrane: Implication of a nonspecific process in efficient intracellular gene delivery Hydrodynamics-based procedure involves transient hyperpermeability in the hepatic cellular membrane: Implication of a nonspecific process in efficient intracellular gene delivery Journal of Gene Medicine, 6, 5, 584-592 Journal of Gene Medicine, 6, 5, 584-592 Journal of Gene Medicine, 6, 5, 584-592 2004 英語 公開
M. Nakamura; M. Maruyama; F. Yamashita; Y. Takakura; M. Hashida; Y. Watanabe M. Nakamura; M. Maruyama; F. Yamashita; Y. Takakura; M. Hashida; Y. Watanabe M. Nakamura; M. Maruyama; F. Yamashita; Y. Takakura; M. Hashida; Y. Watanabe Expression and visualization of a human interferon-β-enhanced green fluorescent protein chimeric molecule in cultured cells Expression and visualization of a human interferon-β-enhanced green fluorescent protein chimeric molecule in cultured cells Expression and visualization of a human interferon-β-enhanced green fluorescent protein chimeric molecule in cultured cells Biological and Pharmaceutical Bulletin, 27, 3, 411-414 Biological and Pharmaceutical Bulletin, 27, 3, 411-414 Biological and Pharmaceutical Bulletin, 27, 3, 411-414 2004 英語 公開
M. Nakamura; S. Yamaguchi; Y. Watanabe; F. Yamashita; Y. Takakura; M. Hashida M. Nakamura; S. Yamaguchi; Y. Watanabe; F. Yamashita; Y. Takakura; M. Hashida M. Nakamura; S. Yamaguchi; Y. Watanabe; F. Yamashita; Y. Takakura; M. Hashida Exogenous expression of interferon-β in cultured brain microvessel endothelial cells Exogenous expression of interferon-β in cultured brain microvessel endothelial cells Exogenous expression of interferon-β in cultured brain microvessel endothelial cells Biological and Pharmaceutical Bulletin, 27, 9, 1441-1443 Biological and Pharmaceutical Bulletin, 27, 9, 1441-1443 Biological and Pharmaceutical Bulletin, 27, 9, 1441-1443 2004 英語 公開
M. Maruyama; T. Nishio; T. Yoshida; C. Ishida; K. Ishida; Y. Watanabe; M. Nishikawa; Y. Takakura M. Maruyama; T. Nishio; T. Yoshida; C. Ishida; K. Ishida; Y. Watanabe; M. Nishikawa; Y. Takakura M. Maruyama; T. Nishio; T. Yoshida; C. Ishida; K. Ishida; Y. Watanabe; M. Nishikawa; Y. Takakura Simultaneous detection of DsRed2-tagged and EGFP-tagged human β-interferons in the same single cells Simultaneous detection of DsRed2-tagged and EGFP-tagged human β-interferons in the same single cells Simultaneous detection of DsRed2-tagged and EGFP-tagged human β-interferons in the same single cells Journal of Cellular Biochemistry, 93, 3, 497-502 Journal of Cellular Biochemistry, 93, 3, 497-502 Journal of Cellular Biochemistry, 93, 3, 497-502 2004 英語 公開
T. Nishio; M. Maruyama; T. Yoshida; Y. Watanabe; M. Nishikawa; Y. Takakura T. Nishio; M. Maruyama; T. Yoshida; Y. Watanabe; M. Nishikawa; Y. Takakura T. Nishio; M. Maruyama; T. Yoshida; Y. Watanabe; M. Nishikawa; Y. Takakura Secretion mode and subcellular localization of human interferon-β exogenously expressed in porcine renal epithelial LLC-PK<sub>1</sub> cells Secretion mode and subcellular localization of human interferon-β exogenously expressed in porcine renal epithelial LLC-PK<sub>1</sub> cells Secretion mode and subcellular localization of human interferon-β exogenously expressed in porcine renal epithelial LLC-PK<sub>1</sub> cells Biological and Pharmaceutical Bulletin, 27, 10, 1653-1655 Biological and Pharmaceutical Bulletin, 27, 10, 1653-1655 Biological and Pharmaceutical Bulletin, 27, 10, 1653-1655 2004 英語 公開
K. Furumoto; S. Nagayama; K.-I. Ogawara; Y. Takakura; M. Hashida; K. Higaki; T. Kimura K. Furumoto; S. Nagayama; K.-I. Ogawara; Y. Takakura; M. Hashida; K. Higaki; T. Kimura K. Furumoto; S. Nagayama; K.-I. Ogawara; Y. Takakura; M. Hashida; K. Higaki; T. Kimura Hepatic uptake of negatively charged particles in rats: Possible involvement of serum proteins in recognition by scavenger receptor Hepatic uptake of negatively charged particles in rats: Possible involvement of serum proteins in recognition by scavenger receptor Hepatic uptake of negatively charged particles in rats: Possible involvement of serum proteins in recognition by scavenger receptor Journal of Controlled Release, 97, 1, 133-141 Journal of Controlled Release, 97, 1, 133-141 Journal of Controlled Release, 97, 1, 133-141 2004 英語 公開
K. Shakushiro; Y. Yamasaki; M. Nishikawa; Y. Takakura K. Shakushiro; Y. Yamasaki; M. Nishikawa; Y. Takakura K. Shakushiro; Y. Yamasaki; M. Nishikawa; Y. Takakura Efficient scavenger receptor-mediated uptake and cross-presentation of negatively charged soluble antigens by dendritic cells Efficient scavenger receptor-mediated uptake and cross-presentation of negatively charged soluble antigens by dendritic cells Efficient scavenger receptor-mediated uptake and cross-presentation of negatively charged soluble antigens by dendritic cells Immunology, 112, 2, 211-218 Immunology, 112, 2, 211-218 Immunology, 112, 2, 211-218 2004 英語 公開
T. Ikenaga; Y. Yamasaki; K. Shakushiro; M. Nishikawa; Y. Takakura T. Ikenaga; Y. Yamasaki; K. Shakushiro; M. Nishikawa; Y. Takakura T. Ikenaga; Y. Yamasaki; K. Shakushiro; M. Nishikawa; Y. Takakura Induction of cytotoxic T lymphocytes following immunization with cationized soluble antigen Induction of cytotoxic T lymphocytes following immunization with cationized soluble antigen Induction of cytotoxic T lymphocytes following immunization with cationized soluble antigen Vaccine, 22, 20, 2609-2616 Vaccine, 22, 20, 2609-2616 Vaccine, 22, 20, 2609-2616 2004 英語 公開
J. Hisazumi; N. Kobayashi; M. Nishikawa; Y. Takakura J. Hisazumi; N. Kobayashi; M. Nishikawa; Y. Takakura J. Hisazumi; N. Kobayashi; M. Nishikawa; Y. Takakura Significant role of liver sinusoidal endothelial cells in hepatic uptake and degradation of naked plasmid DNA after intravenous injection Significant role of liver sinusoidal endothelial cells in hepatic uptake and degradation of naked plasmid DNA after intravenous injection Significant role of liver sinusoidal endothelial cells in hepatic uptake and degradation of naked plasmid DNA after intravenous injection Pharmaceutical Research, 21, 7, 1223-1228 Pharmaceutical Research, 21, 7, 1223-1228 Pharmaceutical Research, 21, 7, 1223-1228 2004 英語 公開
M. Maruyama; T. Nishio; T. Kato; T. Yoshida; C. Ishida; Y. Watanabe; M. Nishikawa; Y. Kaneda; Y. Takakura M. Maruyama; T. Nishio; T. Kato; T. Yoshida; C. Ishida; Y. Watanabe; M. Nishikawa; Y. Kaneda; Y. Takakura M. Maruyama; T. Nishio; T. Kato; T. Yoshida; C. Ishida; Y. Watanabe; M. Nishikawa; Y. Kaneda; Y. Takakura Subcellular trafficking of exogenously expressed interferon-β in Madin-Darby canine kidney cells Subcellular trafficking of exogenously expressed interferon-β in Madin-Darby canine kidney cells Subcellular trafficking of exogenously expressed interferon-β in Madin-Darby canine kidney cells Journal of Cellular Physiology, 201, 1, 117-125 Journal of Cellular Physiology, 201, 1, 117-125 Journal of Cellular Physiology, 201, 1, 117-125 2004 英語 公開
N. Kobayashi; K. Hirata; S. Chen; A. Kawase; M. Nishikawa; Y. Takakura N. Kobayashi; K. Hirata; S. Chen; A. Kawase; M. Nishikawa; Y. Takakura N. Kobayashi; K. Hirata; S. Chen; A. Kawase; M. Nishikawa; Y. Takakura Hepatic delivery of particulates in the submicron range by a hydrodynamics-based procedure: Implications for particulate gene delivery systems Hepatic delivery of particulates in the submicron range by a hydrodynamics-based procedure: Implications for particulate gene delivery systems Hepatic delivery of particulates in the submicron range by a hydrodynamics-based procedure: Implications for particulate gene delivery systems Journal of Gene Medicine, 6, 4, 455-463 Journal of Gene Medicine, 6, 4, 455-463 Journal of Gene Medicine, 6, 4, 455-463 2004 英語 公開
M. Nishikawa; A. Tamada; K. Hyoudou; Y. Umeyama; Y. Takahashi; Y. Kobayashi; H. Kumai; E. Ishida; F. Staud; Y. Yabe; Y. Takakura; F. Yamashita; M. Hashida M. Nishikawa; A. Tamada; K. Hyoudou; Y. Umeyama; Y. Takahashi; Y. Kobayashi; H. Kumai; E. Ishida; F. Staud; Y. Yabe; Y. Takakura; F. Yamashita; M. Hashida M. Nishikawa; A. Tamada; K. Hyoudou; Y. Umeyama; Y. Takahashi; Y. Kobayashi; H. Kumai; E. Ishida; F. Staud; Y. Yabe; Y. Takakura; F. Yamashita; M. Hashida Inhibition of experimental hepatic metastasis by targeted delivery of catalase in mice Inhibition of experimental hepatic metastasis by targeted delivery of catalase in mice Inhibition of experimental hepatic metastasis by targeted delivery of catalase in mice Clinical and Experimental Metastasis, 21, 3, 213-221 Clinical and Experimental Metastasis, 21, 3, 213-221 Clinical and Experimental Metastasis, 21, 3, 213-221 2004 英語 公開
K. Yamaoka; Y. Takakura K. Yamaoka; Y. Takakura K. Yamaoka; Y. Takakura Analysis methods and recent advances in nonlinear pharmacokinetics from in vitro through in loci to in vivo. Analysis methods and recent advances in nonlinear pharmacokinetics from in vitro through in loci to in vivo. Analysis methods and recent advances in nonlinear pharmacokinetics from in vitro through in loci to in vivo. Drug metabolism and pharmacokinetics, 19, 6, 397-406 Drug metabolism and pharmacokinetics, 19, 6, 397-406 Drug metabolism and pharmacokinetics, 19, 6, 397-406 2004 英語 公開
Y. Takakura Y. Takakura Y. Takakura Cancer gene therapy - Gene delivery research Cancer gene therapy - Gene delivery research Cancer gene therapy - Gene delivery research Biotherapy, 18, 3, 253-257 Biotherapy, 18, 3, 253-257 Biotherapy, 18, 3, 253-257 2004 英語 公開
M. Nishikawa; T. Nakano; T. Okabe; N. Hamaguchi; Y. Yamasaki; Y. Takakura; F. Yamashita; M. Hashida M. Nishikawa; T. Nakano; T. Okabe; N. Hamaguchi; Y. Yamasaki; Y. Takakura; F. Yamashita; M. Hashida M. Nishikawa; T. Nakano; T. Okabe; N. Hamaguchi; Y. Yamasaki; Y. Takakura; F. Yamashita; M. Hashida Residualizing indium-111-radiolabel for plasmid DNA and its application to tissue distribution study Residualizing indium-111-radiolabel for plasmid DNA and its application to tissue distribution study Residualizing indium-111-radiolabel for plasmid DNA and its application to tissue distribution study Bioconjugate Chemistry, 14, 5, 955-961 Bioconjugate Chemistry, 14, 5, 955-961 Bioconjugate Chemistry, 14, 5, 955-961 2003/09 英語 公開
A. Kawase; T. Nomura; K. Yasuda; N. Kobayashi; M. Hashida; Y. Takakura A. Kawase; T. Nomura; K. Yasuda; N. Kobayashi; M. Hashida; Y. Takakura A. Kawase; T. Nomura; K. Yasuda; N. Kobayashi; M. Hashida; Y. Takakura Disposition and gene expression characteristics in solid tumors and skeletal muscle after direct injection of naked plasmid DNA in mice Disposition and gene expression characteristics in solid tumors and skeletal muscle after direct injection of naked plasmid DNA in mice Disposition and gene expression characteristics in solid tumors and skeletal muscle after direct injection of naked plasmid DNA in mice Journal of Pharmaceutical Sciences, 92, 6, 1295-1304 Journal of Pharmaceutical Sciences, 92, 6, 1295-1304 Journal of Pharmaceutical Sciences, 92, 6, 1295-1304 2003 英語 公開
F. Sakurai; T. Terada; M. Maruyama; Y. Watanabe; F. Yamashita; Y. Takakura; M. Hashida F. Sakurai; T. Terada; M. Maruyama; Y. Watanabe; F. Yamashita; Y. Takakura; M. Hashida F. Sakurai; T. Terada; M. Maruyama; Y. Watanabe; F. Yamashita; Y. Takakura; M. Hashida Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-β gene and poly I: Poly C in a murine lung metastasis model Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-β gene and poly I: Poly C in a murine lung metastasis model Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-β gene and poly I: Poly C in a murine lung metastasis model Cancer Gene Therapy, 10, 9, 661-668 Cancer Gene Therapy, 10, 9, 661-668 Cancer Gene Therapy, 10, 9, 661-668 2003 英語 公開
F. Verbaan; I. Van Dam; Y. Takakura; M. Hashida; W. Hennink; G. Storm; C. Oussoren F. Verbaan; I. Van Dam; Y. Takakura; M. Hashida; W. Hennink; G. Storm; C. Oussoren F. Verbaan; I. Van Dam; Y. Takakura; M. Hashida; W. Hennink; G. Storm; C. Oussoren Intravenous fate of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes Intravenous fate of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes Intravenous fate of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes European Journal of Pharmaceutical Sciences, 20, 4-5, 419-427 European Journal of Pharmaceutical Sciences, 20, 4-5, 419-427 European Journal of Pharmaceutical Sciences, 20, 4-5, 419-427 2003 英語 公開
M. Anraku; U. Kragh-Hansen; K. Kawai; T. Maruyama; Y. Yamasaki; Y. Takakura; M. Otagiri M. Anraku; U. Kragh-Hansen; K. Kawai; T. Maruyama; Y. Yamasaki; Y. Takakura; M. Otagiri M. Anraku; U. Kragh-Hansen; K. Kawai; T. Maruyama; Y. Yamasaki; Y. Takakura; M. Otagiri Validation of the chloramine-T induced oxidation of human serum albumin as a model for oxidative damage in vivo Validation of the chloramine-T induced oxidation of human serum albumin as a model for oxidative damage in vivo Validation of the chloramine-T induced oxidation of human serum albumin as a model for oxidative damage in vivo Pharmaceutical Research, 20, 4, 684-692 Pharmaceutical Research, 20, 4, 684-692 Pharmaceutical Research, 20, 4, 684-692 2003 英語 公開
Y. Yamasaki; J. Hisazumi; K. Yamaoka; Y. Takakura Y. Yamasaki; J. Hisazumi; K. Yamaoka; Y. Takakura Y. Yamasaki; J. Hisazumi; K. Yamaoka; Y. Takakura Efficient scavenger receptor-mediated hepatic targeting of proteins by introduction of negative charges on the proteins by aconitylation: The influence of charge density and size of the proteins molecules Efficient scavenger receptor-mediated hepatic targeting of proteins by introduction of negative charges on the proteins by aconitylation: The influence of charge density and size of the proteins molecules Efficient scavenger receptor-mediated hepatic targeting of proteins by introduction of negative charges on the proteins by aconitylation: The influence of charge density and size of the proteins molecules European Journal of Pharmaceutical Sciences, 18, 5, 305-312 European Journal of Pharmaceutical Sciences, 18, 5, 305-312 European Journal of Pharmaceutical Sciences, 18, 5, 305-312 2003 英語 公開
T. Yoshinaga; K. Yasuda; Y. Ogawa; Y. Takakura T. Yoshinaga; K. Yasuda; Y. Ogawa; Y. Takakura T. Yoshinaga; K. Yasuda; Y. Ogawa; Y. Takakura Efficient uptake and rapid degradation of plasmid DNA by murine dendritic cells via a specific mechanism Efficient uptake and rapid degradation of plasmid DNA by murine dendritic cells via a specific mechanism Efficient uptake and rapid degradation of plasmid DNA by murine dendritic cells via a specific mechanism Biochemical and Biophysical Research Communications, 299, 3, 389-394 Biochemical and Biophysical Research Communications, 299, 3, 389-394 Biochemical and Biophysical Research Communications, 299, 3, 389-394 2002/12/06 英語 公開
Y. Yabe; N. Kobayashi; M. Nishikawa; K. Mihara; F. Yamashita; Y. Takakura; M. Hashida Y. Yabe; N. Kobayashi; M. Nishikawa; K. Mihara; F. Yamashita; Y. Takakura; M. Hashida Y. Yabe; N. Kobayashi; M. Nishikawa; K. Mihara; F. Yamashita; Y. Takakura; M. Hashida Pharmacokinetics and preventive effects of targeted catalase derivatives on hydrogen peroxide-induced injury in perfused rat liver Pharmacokinetics and preventive effects of targeted catalase derivatives on hydrogen peroxide-induced injury in perfused rat liver Pharmacokinetics and preventive effects of targeted catalase derivatives on hydrogen peroxide-induced injury in perfused rat liver Pharmaceutical Research, 19, 12, 1815-1821 Pharmaceutical Research, 19, 12, 1815-1821 Pharmaceutical Research, 19, 12, 1815-1821 2002/12 英語 公開
Y. Akazawa; H. Kawaguchi; M. Funahashi; Y. Watanabe; K. Yamaoka; M. Hashida; Y. Takakura Y. Akazawa; H. Kawaguchi; M. Funahashi; Y. Watanabe; K. Yamaoka; M. Hashida; Y. Takakura Y. Akazawa; H. Kawaguchi; M. Funahashi; Y. Watanabe; K. Yamaoka; M. Hashida; Y. Takakura Effect of interferons on P-glycoprotein-mediated rhodamine-123 efflux in cultured rat hepatocytes Effect of interferons on P-glycoprotein-mediated rhodamine-123 efflux in cultured rat hepatocytes Effect of interferons on P-glycoprotein-mediated rhodamine-123 efflux in cultured rat hepatocytes Journal of Pharmaceutical Sciences, 91, 10, 2110-2115 Journal of Pharmaceutical Sciences, 91, 10, 2110-2115 Journal of Pharmaceutical Sciences, 91, 10, 2110-2115 2002/10 英語 公開
Y. Yamasaki; K. Sumimoto; M. Nishikawa; F. Yamashita; K. Yamaoka; M. Hashida; Y. Takakura Y. Yamasaki; K. Sumimoto; M. Nishikawa; F. Yamashita; K. Yamaoka; M. Hashida; Y. Takakura Y. Yamasaki; K. Sumimoto; M. Nishikawa; F. Yamashita; K. Yamaoka; M. Hashida; Y. Takakura Pharmacokinetic analysis of in vivo disposition of succinylated proteins targeted to liver nonparenchymal cells via scavenger receptors: Importance of molecular size and negative charge density for in vivo recognition by receptors Pharmacokinetic analysis of in vivo disposition of succinylated proteins targeted to liver nonparenchymal cells via scavenger receptors: Importance of molecular size and negative charge density for in vivo recognition by receptors Pharmacokinetic analysis of in vivo disposition of succinylated proteins targeted to liver nonparenchymal cells via scavenger receptors: Importance of molecular size and negative charge density for in vivo recognition by receptors Journal of Pharmacology and Experimental Therapeutics, 301, 2, 467-477 Journal of Pharmacology and Experimental Therapeutics, 301, 2, 467-477 Journal of Pharmacology and Experimental Therapeutics, 301, 2, 467-477 2002/05 英語 公開
K. Yasuda; Y. Ogawa; M. Kishimoto; T. Takagi; M. Hashida; Y. Takakura K. Yasuda; Y. Ogawa; M. Kishimoto; T. Takagi; M. Hashida; Y. Takakura K. Yasuda; Y. Ogawa; M. Kishimoto; T. Takagi; M. Hashida; Y. Takakura Plasmid DNA activates murine macrophages to induce inflammatory cytokines in a CpG motif-independent manner by complex formation with cationic liposomes Plasmid DNA activates murine macrophages to induce inflammatory cytokines in a CpG motif-independent manner by complex formation with cationic liposomes Plasmid DNA activates murine macrophages to induce inflammatory cytokines in a CpG motif-independent manner by complex formation with cationic liposomes Biochemical and Biophysical Research Communications, 293, 1, 344-348 Biochemical and Biophysical Research Communications, 293, 1, 344-348 Biochemical and Biophysical Research Communications, 293, 1, 344-348 2002/04/26 英語 公開
Y. Takakura; M. Nishikawa; F. Yamashita; M. Hashida Y. Takakura; M. Nishikawa; F. Yamashita; M. Hashida Y. Takakura; M. Nishikawa; F. Yamashita; M. Hashida Influence of physicochemical properties on pharmacokinetics of non-viral vectors for gene delivery Influence of physicochemical properties on pharmacokinetics of non-viral vectors for gene delivery Influence of physicochemical properties on pharmacokinetics of non-viral vectors for gene delivery Journal of Drug Targeting, 10, 2, 99-104 Journal of Drug Targeting, 10, 2, 99-104 Journal of Drug Targeting, 10, 2, 99-104 2002/03 英語 公開
F. Sakurai; T. Terada; K. Yasuda; F. Yamashita; Y. Takakura; M. Hashida F. Sakurai; T. Terada; K. Yasuda; F. Yamashita; Y. Takakura; M. Hashida F. Sakurai; T. Terada; K. Yasuda; F. Yamashita; Y. Takakura; M. Hashida The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes Gene Therapy, 9, 16, 1120-1126 Gene Therapy, 9, 16, 1120-1126 Gene Therapy, 9, 16, 1120-1126 2002 英語 公開
N. Kobayashi; T. Kuramoto; S. Chen; Y. Watanabe; Y. Takakura N. Kobayashi; T. Kuramoto; S. Chen; Y. Watanabe; Y. Takakura N. Kobayashi; T. Kuramoto; S. Chen; Y. Watanabe; Y. Takakura Therapeutic effect of intravenous interferon gene delivery with naked plasmid DNA in murine metastasis models Therapeutic effect of intravenous interferon gene delivery with naked plasmid DNA in murine metastasis models Therapeutic effect of intravenous interferon gene delivery with naked plasmid DNA in murine metastasis models Molecular Therapy, 6, 6, 737-744 Molecular Therapy, 6, 6, 737-744 Molecular Therapy, 6, 6, 737-744 2002 英語 公開
K. Nakanishi; Y. Watanabe; M. Maruyama; F. Yamashita; Y. Takakura; M. Hashida K. Nakanishi; Y. Watanabe; M. Maruyama; F. Yamashita; Y. Takakura; M. Hashida K. Nakanishi; Y. Watanabe; M. Maruyama; F. Yamashita; Y. Takakura; M. Hashida Secretion polarity of interferon-β in epithelial cell lines Secretion polarity of interferon-β in epithelial cell lines Secretion polarity of interferon-β in epithelial cell lines Archives of Biochemistry and Biophysics, 402, 2, 201-207 Archives of Biochemistry and Biophysics, 402, 2, 201-207 Archives of Biochemistry and Biophysics, 402, 2, 201-207 2002 英語 公開
K. Furumoto; K.-I. Ogawara; S. Nagayama; Y. Takakura; M. Hashida; K. Higaki; T. Kimura K. Furumoto; K.-I. Ogawara; S. Nagayama; Y. Takakura; M. Hashida; K. Higaki; T. Kimura K. Furumoto; K.-I. Ogawara; S. Nagayama; Y. Takakura; M. Hashida; K. Higaki; T. Kimura Important role of serum proteins associated on the surface of particles in their hepatic disposition Important role of serum proteins associated on the surface of particles in their hepatic disposition Important role of serum proteins associated on the surface of particles in their hepatic disposition Journal of Controlled Release, 83, 1, 89-96 Journal of Controlled Release, 83, 1, 89-96 Journal of Controlled Release, 83, 1, 89-96 2002 英語 公開
M. Nishikawa; S. Hasegawa; F. Yamashita; Y. Takakura; M. Hashida M. Nishikawa; S. Hasegawa; F. Yamashita; Y. Takakura; M. Hashida M. Nishikawa; S. Hasegawa; F. Yamashita; Y. Takakura; M. Hashida Electrical charge on protein regulates its absorption from the rat small intestine Electrical charge on protein regulates its absorption from the rat small intestine Electrical charge on protein regulates its absorption from the rat small intestine American Journal of Physiology - Gastrointestinal and Liver Physiology, 282, 4 45-4, G711-G719 American Journal of Physiology - Gastrointestinal and Liver Physiology, 282, 4 45-4, G711-G719 American Journal of Physiology - Gastrointestinal and Liver Physiology, 282, 4 45-4, G711-G719 2002 英語 公開
K. Akamatsu; Y. Yamasaki; M. Nishikawa; Y. Takakura; M. Hashida K. Akamatsu; Y. Yamasaki; M. Nishikawa; Y. Takakura; M. Hashida K. Akamatsu; Y. Yamasaki; M. Nishikawa; Y. Takakura; M. Hashida Synthesis and pharmacological activity of a novel water-soluble hepatocyte-specific polymeric prodrug of prostaglandin E<sub>1</sub> using lactosylated poly(L-glutamic hydrazide) as a carrier Synthesis and pharmacological activity of a novel water-soluble hepatocyte-specific polymeric prodrug of prostaglandin E<sub>1</sub> using lactosylated poly(L-glutamic hydrazide) as a carrier Synthesis and pharmacological activity of a novel water-soluble hepatocyte-specific polymeric prodrug of prostaglandin E<sub>1</sub> using lactosylated poly(L-glutamic hydrazide) as a carrier Biochemical Pharmacology, 62, 11, 1531-1536 Biochemical Pharmacology, 62, 11, 1531-1536 Biochemical Pharmacology, 62, 11, 1531-1536 2001/12/01 英語 公開
M. Hashida; M. Nishikawa; F. Yamashita; Y. Takakura M. Hashida; M. Nishikawa; F. Yamashita; Y. Takakura M. Hashida; M. Nishikawa; F. Yamashita; Y. Takakura Cell-specific delivery of genes with glycosylated carriers Cell-specific delivery of genes with glycosylated carriers Cell-specific delivery of genes with glycosylated carriers Advanced Drug Delivery Reviews, 52, 3, 187-196 Advanced Drug Delivery Reviews, 52, 3, 187-196 Advanced Drug Delivery Reviews, 52, 3, 187-196 2001/11/19 英語 公開
Y. Yabe; N. Kobayashi; T. Nishihashi; R. Takahashi; M. Nishikawa; Y. Takakura; M. Hashida Y. Yabe; N. Kobayashi; T. Nishihashi; R. Takahashi; M. Nishikawa; Y. Takakura; M. Hashida Y. Yabe; N. Kobayashi; T. Nishihashi; R. Takahashi; M. Nishikawa; Y. Takakura; M. Hashida Prevention of neutrophil-mediated hepatic ischemia/reperfusion injury by superoxide dismutase and catalase derivatives Prevention of neutrophil-mediated hepatic ischemia/reperfusion injury by superoxide dismutase and catalase derivatives Prevention of neutrophil-mediated hepatic ischemia/reperfusion injury by superoxide dismutase and catalase derivatives Journal of Pharmacology and Experimental Therapeutics, 298, 3, 894-899 Journal of Pharmacology and Experimental Therapeutics, 298, 3, 894-899 Journal of Pharmacology and Experimental Therapeutics, 298, 3, 894-899 2001/09 英語 公開
Y. Imamura; K. Shimizu; F. Yamashita; K. Yamaoka; Y. Takakura; M. Hashida Y. Imamura; K. Shimizu; F. Yamashita; K. Yamaoka; Y. Takakura; M. Hashida Y. Imamura; K. Shimizu; F. Yamashita; K. Yamaoka; Y. Takakura; M. Hashida Transport characteristics of ebastine and its metabolites across human intestinal epithelial Caco-2 cell monolayers Transport characteristics of ebastine and its metabolites across human intestinal epithelial Caco-2 cell monolayers Transport characteristics of ebastine and its metabolites across human intestinal epithelial Caco-2 cell monolayers Biological and Pharmaceutical Bulletin, 24, 8, 930-934 Biological and Pharmaceutical Bulletin, 24, 8, 930-934 Biological and Pharmaceutical Bulletin, 24, 8, 930-934 2001/08 英語 公開
N. Kobayashi; T. Kuramoto; K. Yamaoka; M. Hashida; Y. Takakura N. Kobayashi; T. Kuramoto; K. Yamaoka; M. Hashida; Y. Takakura N. Kobayashi; T. Kuramoto; K. Yamaoka; M. Hashida; Y. Takakura Hepatic uptake and gene expression mechanisms following intravenous administration of plasmid DNA by conventional and hydrodynamics-based procedures Hepatic uptake and gene expression mechanisms following intravenous administration of plasmid DNA by conventional and hydrodynamics-based procedures Hepatic uptake and gene expression mechanisms following intravenous administration of plasmid DNA by conventional and hydrodynamics-based procedures Journal of Pharmacology and Experimental Therapeutics, 297, 3, 853-860 Journal of Pharmacology and Experimental Therapeutics, 297, 3, 853-860 Journal of Pharmacology and Experimental Therapeutics, 297, 3, 853-860 2001/06 英語 公開
F. Sakurai; T. Nishioka; H. Saito; T. Baba; A. Okuda; O. Matsumoto; T. Taga; F. Yamashita; Y. Takakura; M. Hashida F. Sakurai; T. Nishioka; H. Saito; T. Baba; A. Okuda; O. Matsumoto; T. Taga; F. Yamashita; Y. Takakura; M. Hashida F. Sakurai; T. Nishioka; H. Saito; T. Baba; A. Okuda; O. Matsumoto; T. Taga; F. Yamashita; Y. Takakura; M. Hashida Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: The role of the neutral helper lipid Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: The role of the neutral helper lipid Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: The role of the neutral helper lipid Gene Therapy, 8, 9, 677-686 Gene Therapy, 8, 9, 677-686 Gene Therapy, 8, 9, 677-686 2001/05 英語 公開
Y. Takakura; M. Nishikawa; F. Yamashita; M. Hashida Y. Takakura; M. Nishikawa; F. Yamashita; M. Hashida Y. Takakura; M. Nishikawa; F. Yamashita; M. Hashida Development of gene drug delivery systems based on pharmacokinetic studies Development of gene drug delivery systems based on pharmacokinetic studies Development of gene drug delivery systems based on pharmacokinetic studies European Journal of Pharmaceutical Sciences, 13, 1, 71-76 European Journal of Pharmaceutical Sciences, 13, 1, 71-76 European Journal of Pharmaceutical Sciences, 13, 1, 71-76 2001/04 英語 公開
F. Sakurai; T. Nishioka; F. Yamashita; Y. Takakura; M. Hashida F. Sakurai; T. Nishioka; F. Yamashita; Y. Takakura; M. Hashida F. Sakurai; T. Nishioka; F. Yamashita; Y. Takakura; M. Hashida Effects of erythrocytes and serum proteins on lung accumulation of lipoplexes containing cholesterol or DOPE as a helper lipid in the single-pass rat lung perfusion system Effects of erythrocytes and serum proteins on lung accumulation of lipoplexes containing cholesterol or DOPE as a helper lipid in the single-pass rat lung perfusion system Effects of erythrocytes and serum proteins on lung accumulation of lipoplexes containing cholesterol or DOPE as a helper lipid in the single-pass rat lung perfusion system European Journal of Pharmaceutics and Biopharmaceutics, 52, 2, 165-172 European Journal of Pharmaceutics and Biopharmaceutics, 52, 2, 165-172 European Journal of Pharmaceutics and Biopharmaceutics, 52, 2, 165-172 2001 英語 公開
K. Furumoto; K.-I. Ogawara; M. Yoshida; Y. Takakura; M. Hashida; K. Higaki; T. Kimura K. Furumoto; K.-I. Ogawara; M. Yoshida; Y. Takakura; M. Hashida; K. Higaki; T. Kimura K. Furumoto; K.-I. Ogawara; M. Yoshida; Y. Takakura; M. Hashida; K. Higaki; T. Kimura Biliary excretion of polystyrene microspheres depends on the type of receptor-mediated uptake in rat liver Biliary excretion of polystyrene microspheres depends on the type of receptor-mediated uptake in rat liver Biliary excretion of polystyrene microspheres depends on the type of receptor-mediated uptake in rat liver Biochimica et Biophysica Acta - General Subjects, 1526, 2, 221-226 Biochimica et Biophysica Acta - General Subjects, 1526, 2, 221-226 Biochimica et Biophysica Acta - General Subjects, 1526, 2, 221-226 2001 英語 公開
K.-I. Ogawara; K. Furumoto; Y. Takakura; M. Hashida; K. Higaki; T. Kimura K.-I. Ogawara; K. Furumoto; Y. Takakura; M. Hashida; K. Higaki; T. Kimura K.-I. Ogawara; K. Furumoto; Y. Takakura; M. Hashida; K. Higaki; T. Kimura Surface hydrophobicity of particles is not necessarily the most important determinant in their in vivo disposition after intravenous administration in rats Surface hydrophobicity of particles is not necessarily the most important determinant in their in vivo disposition after intravenous administration in rats Surface hydrophobicity of particles is not necessarily the most important determinant in their in vivo disposition after intravenous administration in rats Journal of Controlled Release, 77, 3, 191-198 Journal of Controlled Release, 77, 3, 191-198 Journal of Controlled Release, 77, 3, 191-198 2001 英語 公開
F.J. Verbaan; C. Oussoren; I.M. Van Dam; Y. Takakura; M. Hashida; D.J.A. Crommelin; W.E. Hennink; G. Storm F.J. Verbaan; C. Oussoren; I.M. Van Dam; Y. Takakura; M. Hashida; D.J.A. Crommelin; W.E. Hennink; G. Storm F.J. Verbaan; C. Oussoren; I.M. Van Dam; Y. Takakura; M. Hashida; D.J.A. Crommelin; W.E. Hennink; G. Storm The fate of poly(2-dimethyl amino ethyl)methacrylate-based polyplexes after intravenous administration The fate of poly(2-dimethyl amino ethyl)methacrylate-based polyplexes after intravenous administration The fate of poly(2-dimethyl amino ethyl)methacrylate-based polyplexes after intravenous administration International Journal of Pharmaceutics, 214, 1/2, 99-101 International Journal of Pharmaceutics, 214, 1/2, 99-101 International Journal of Pharmaceutics, 214, 1/2, 99-101 2001 英語 公開
P. Opanasopit; K. Shirashi; M. Nishikawa; F. Yamashita; Y. Takakura; M. Hashida P. Opanasopit; K. Shirashi; M. Nishikawa; F. Yamashita; Y. Takakura; M. Hashida P. Opanasopit; K. Shirashi; M. Nishikawa; F. Yamashita; Y. Takakura; M. Hashida In vivo recognition of mannosylated proteins by hepatic mannose receptors and mannan-binding protein In vivo recognition of mannosylated proteins by hepatic mannose receptors and mannan-binding protein In vivo recognition of mannosylated proteins by hepatic mannose receptors and mannan-binding protein American Journal of Physiology - Gastrointestinal and Liver Physiology, 280, 5 43-5, G879-G889 American Journal of Physiology - Gastrointestinal and Liver Physiology, 280, 5 43-5, G879-G889 American Journal of Physiology - Gastrointestinal and Liver Physiology, 280, 5 43-5, G879-G889 2001 英語 公開
P. Opanasopit; M. Nishikawa; F. Yamashita; Y. Takakura; M. Hashida P. Opanasopit; M. Nishikawa; F. Yamashita; Y. Takakura; M. Hashida P. Opanasopit; M. Nishikawa; F. Yamashita; Y. Takakura; M. Hashida Pharmacokinetic analysis of lectin-dependent biodistribution of fucosylated bovine serum albumin: A possible carrier for Kupffer cells Pharmacokinetic analysis of lectin-dependent biodistribution of fucosylated bovine serum albumin: A possible carrier for Kupffer cells Pharmacokinetic analysis of lectin-dependent biodistribution of fucosylated bovine serum albumin: A possible carrier for Kupffer cells Journal of Drug Targeting, 9, 5, 341-351 Journal of Drug Targeting, 9, 5, 341-351 Journal of Drug Targeting, 9, 5, 341-351 2001 英語 公開
F. Sakurai; R. Inoue; Y. Nishino; A. Okuda; O. Matsumoto; T. Taga; F. Yamashita; Y. Takakura; M. Hashida F. Sakurai; R. Inoue; Y. Nishino; A. Okuda; O. Matsumoto; T. Taga; F. Yamashita; Y. Takakura; M. Hashida F. Sakurai; R. Inoue; Y. Nishino; A. Okuda; O. Matsumoto; T. Taga; F. Yamashita; Y. Takakura; M. Hashida Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression Journal of Controlled Release, 66, 2/3, 255-269 Journal of Controlled Release, 66, 2/3, 255-269 Journal of Controlled Release, 66, 2/3, 255-269 2000/05/15 英語 公開
M. Nishikawa; M. Yamauchi; K. Morimoto; E. Ishida; Y. Takakura; M. Hashida M. Nishikawa; M. Yamauchi; K. Morimoto; E. Ishida; Y. Takakura; M. Hashida M. Nishikawa; M. Yamauchi; K. Morimoto; E. Ishida; Y. Takakura; M. Hashida Hepatocyte-targeted in vivo gene expression by intravenous injection of plasmid DNA complexed with synthetic multi-functional gene delivery system Hepatocyte-targeted in vivo gene expression by intravenous injection of plasmid DNA complexed with synthetic multi-functional gene delivery system Hepatocyte-targeted in vivo gene expression by intravenous injection of plasmid DNA complexed with synthetic multi-functional gene delivery system Gene Therapy, 7, 7, 548-555 Gene Therapy, 7, 7, 548-555 Gene Therapy, 7, 7, 548-555 2000/04 英語 公開
S. Nakajima; Y. Koshino; T. Nomura; F. Yamashita; S. Agrawal; Y. Takakura; M. Hashida S. Nakajima; Y. Koshino; T. Nomura; F. Yamashita; S. Agrawal; Y. Takakura; M. Hashida S. Nakajima; Y. Koshino; T. Nomura; F. Yamashita; S. Agrawal; Y. Takakura; M. Hashida Intratumoral pharmacokinetics of oligonucleotides in a tissue-isolated tumor perfusion system Intratumoral pharmacokinetics of oligonucleotides in a tissue-isolated tumor perfusion system Intratumoral pharmacokinetics of oligonucleotides in a tissue-isolated tumor perfusion system Antisense and Nucleic Acid Drug Development, 10, 2, 105-110 Antisense and Nucleic Acid Drug Development, 10, 2, 105-110 Antisense and Nucleic Acid Drug Development, 10, 2, 105-110 2000/04 英語 公開
M. Hashida; K. Akamatsu; M. Nishikawa; F. Yamashita; H. Yoshikawa; Y. Takakura M. Hashida; K. Akamatsu; M. Nishikawa; F. Yamashita; H. Yoshikawa; Y. Takakura M. Hashida; K. Akamatsu; M. Nishikawa; F. Yamashita; H. Yoshikawa; Y. Takakura Design of polymeric prodrugs of PGE1 for cell-specific hepatic targeting Design of polymeric prodrugs of PGE1 for cell-specific hepatic targeting Design of polymeric prodrugs of PGE1 for cell-specific hepatic targeting Pharmazie, 55, 3, 202-205 Pharmazie, 55, 3, 202-205 Pharmazie, 55, 3, 202-205 2000/03 英語 公開
Takagi, T; Hashiguchi, M; Hiramatsu, T; Yamashita, F; Takakura, Y; Hashida, M Takagi, T; Hashiguchi, M; Hiramatsu, T; Yamashita, F; Takakura, Y; Hashida, M Takagi, T; Hashiguchi, M; Hiramatsu, T; Yamashita, F; Takakura, Y; Hashida, M Effect of cationic liposomes on intracellular trafficking and efficacy of antisense oligonucleotides in mouse peritoneal macrophages Effect of cationic liposomes on intracellular trafficking and efficacy of antisense oligonucleotides in mouse peritoneal macrophages Effect of cationic liposomes on intracellular trafficking and efficacy of antisense oligonucleotides in mouse peritoneal macrophages JOURNAL OF DRUG TARGETING, 7, 5, 363-+ JOURNAL OF DRUG TARGETING, 7, 5, 363-+ JOURNAL OF DRUG TARGETING, 7, 5, 363-+ 2000 英語 公開
M. Nishikawa; S. Takemura; F. Yamashita; Y. Takakura; D.K.F. Meijer; M. Hashida; P.J. Swart M. Nishikawa; S. Takemura; F. Yamashita; Y. Takakura; D.K.F. Meijer; M. Hashida; P.J. Swart M. Nishikawa; S. Takemura; F. Yamashita; Y. Takakura; D.K.F. Meijer; M. Hashida; P.J. Swart Pharmacokinetics and in vivo gene transfer of plasmid DNA complexed with mannosylated poly(L-lysine) in mice Pharmacokinetics and in vivo gene transfer of plasmid DNA complexed with mannosylated poly(L-lysine) in mice Pharmacokinetics and in vivo gene transfer of plasmid DNA complexed with mannosylated poly(L-lysine) in mice Journal of Drug Targeting, 8, 1, 29-38 Journal of Drug Targeting, 8, 1, 29-38 Journal of Drug Targeting, 8, 1, 29-38 2000 英語 公開
T. Takagi; M. Hashiguchi; T. Hiramatsu; F. Yamashita; Y. Takakura; M. Hashida T. Takagi; M. Hashiguchi; T. Hiramatsu; F. Yamashita; Y. Takakura; M. Hashida T. Takagi; M. Hashiguchi; T. Hiramatsu; F. Yamashita; Y. Takakura; M. Hashida Effect of cationic liposomes on intracellular trafficking and efficacy of antisense oligonucleotides in mouse peritoneal macrophages Effect of cationic liposomes on intracellular trafficking and efficacy of antisense oligonucleotides in mouse peritoneal macrophages Effect of cationic liposomes on intracellular trafficking and efficacy of antisense oligonucleotides in mouse peritoneal macrophages Journal of Drug Targeting, 7, 5, 363-371 Journal of Drug Targeting, 7, 5, 363-371 Journal of Drug Targeting, 7, 5, 363-371 2000 英語 公開
F. Sakurai; R. Inoue; Y. Nishino; A. Okuda; O. Matsumoto; T. Taga; F. Yamashita; Y. Takakura; M. Hashida F. Sakurai; R. Inoue; Y. Nishino; A. Okuda; O. Matsumoto; T. Taga; F. Yamashita; Y. Takakura; M. Hashida F. Sakurai; R. Inoue; Y. Nishino; A. Okuda; O. Matsumoto; T. Taga; F. Yamashita; Y. Takakura; M. Hashida Erratum: Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression (Journal of Controlled Release 66 (2000) (255-269) Erratum: Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression (Journal of Controlled Release 66 (2000) (255-269) Erratum: Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression (Journal of Controlled Release 66 (2000) (255-269) Journal of Controlled Release, 69, 1, 219-220 Journal of Controlled Release, 69, 1, 219-220 Journal of Controlled Release, 69, 1, 219-220 2000 英語 公開
T. Kageyama; M. Nakamura; A. Matsuo; Y. Yamasaki; Y. Takakura; M. Hashida; Y. Kanai; M. Naito; T. Tsuruo; N. Minato; S. Shimohama T. Kageyama; M. Nakamura; A. Matsuo; Y. Yamasaki; Y. Takakura; M. Hashida; Y. Kanai; M. Naito; T. Tsuruo; N. Minato; S. Shimohama T. Kageyama; M. Nakamura; A. Matsuo; Y. Yamasaki; Y. Takakura; M. Hashida; Y. Kanai; M. Naito; T. Tsuruo; N. Minato; S. Shimohama The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier Brain Research, 879, 1/2, 115-121 Brain Research, 879, 1/2, 115-121 Brain Research, 879, 1/2, 115-121 2000 英語 公開
M. Hashida; K. Akamatsu; M. Nishikawa; F. Yamashita; Y. Takakura M. Hashida; K. Akamatsu; M. Nishikawa; F. Yamashita; Y. Takakura M. Hashida; K. Akamatsu; M. Nishikawa; F. Yamashita; Y. Takakura Design of polymeric prodrugs of prostaglandin E<sub>1</sub> having galactose residue for hepatocyte targeting Design of polymeric prodrugs of prostaglandin E<sub>1</sub> having galactose residue for hepatocyte targeting Design of polymeric prodrugs of prostaglandin E<sub>1</sub> having galactose residue for hepatocyte targeting Journal of Controlled Release, 62, 1/2, 253-262 Journal of Controlled Release, 62, 1/2, 253-262 Journal of Controlled Release, 62, 1/2, 253-262 1999/11/01 英語 公開
K.-I. Ogawara; M. Yoshida; J.-I. Kubo; M. Nishikawa; Y. Takakura; M. Hashida; K. Higaki; T. Kimura K.-I. Ogawara; M. Yoshida; J.-I. Kubo; M. Nishikawa; Y. Takakura; M. Hashida; K. Higaki; T. Kimura K.-I. Ogawara; M. Yoshida; J.-I. Kubo; M. Nishikawa; Y. Takakura; M. Hashida; K. Higaki; T. Kimura Mechanisms of hepatic disposition of polystyrene microspheres in rats: Effects of serum depend on the sizes of microspheres Mechanisms of hepatic disposition of polystyrene microspheres in rats: Effects of serum depend on the sizes of microspheres Mechanisms of hepatic disposition of polystyrene microspheres in rats: Effects of serum depend on the sizes of microspheres Journal of Controlled Release, 61, 3, 241-250 Journal of Controlled Release, 61, 3, 241-250 Journal of Controlled Release, 61, 3, 241-250 1999/09/20 英語 公開
K. Akamatsu; Y. Yamasaki; M. Nishikawa; Y. Takakura; M. Hashida K. Akamatsu; Y. Yamasaki; M. Nishikawa; Y. Takakura; M. Hashida K. Akamatsu; Y. Yamasaki; M. Nishikawa; Y. Takakura; M. Hashida Development of a hepatocyte-specific prostaglandin E<sub>1</sub> polymeric prodrug and its potential for preventing carbon tetrachloride-induced fulminant hepatitis in mice Development of a hepatocyte-specific prostaglandin E<sub>1</sub> polymeric prodrug and its potential for preventing carbon tetrachloride-induced fulminant hepatitis in mice Development of a hepatocyte-specific prostaglandin E<sub>1</sub> polymeric prodrug and its potential for preventing carbon tetrachloride-induced fulminant hepatitis in mice Journal of Pharmacology and Experimental Therapeutics, 290, 3, 1242-1249 Journal of Pharmacology and Experimental Therapeutics, 290, 3, 1242-1249 Journal of Pharmacology and Experimental Therapeutics, 290, 3, 1242-1249 1999/09 英語 公開
F. Staud; M. Nishikawa; K. Morimoto; Y. Takakura; M. Hashida F. Staud; M. Nishikawa; K. Morimoto; Y. Takakura; M. Hashida F. Staud; M. Nishikawa; K. Morimoto; Y. Takakura; M. Hashida Disposition of radioactivity after injection of liver-targeted proteins labeled with <sup>111</sup>In or <sup>125</sup>I. Effect of labeling on distribution and excretion of radioactivity in rats Disposition of radioactivity after injection of liver-targeted proteins labeled with <sup>111</sup>In or <sup>125</sup>I. Effect of labeling on distribution and excretion of radioactivity in rats Disposition of radioactivity after injection of liver-targeted proteins labeled with <sup>111</sup>In or <sup>125</sup>I. Effect of labeling on distribution and excretion of radioactivity in rats Journal of Pharmaceutical Sciences, 88, 6, 577-585 Journal of Pharmaceutical Sciences, 88, 6, 577-585 Journal of Pharmaceutical Sciences, 88, 6, 577-585 1999/06 英語 公開
K.-I. Ogawara; M. Yoshida; K. Higaki; Toshikiro Kimura; K. Shiraishi; M. Nishikawa; Y. Takakura; M. Hashida K.-I. Ogawara; M. Yoshida; K. Higaki; Toshikiro Kimura; K. Shiraishi; M. Nishikawa; Y. Takakura; M. Hashida K.-I. Ogawara; M. Yoshida; K. Higaki; Toshikiro Kimura; K. Shiraishi; M. Nishikawa; Y. Takakura; M. Hashida Hepatic uptake of polystyrene microspheres in rats: Effect of particle size on intrahepatic distribution Hepatic uptake of polystyrene microspheres in rats: Effect of particle size on intrahepatic distribution Hepatic uptake of polystyrene microspheres in rats: Effect of particle size on intrahepatic distribution Journal of Controlled Release, 59, 1, 15-22 Journal of Controlled Release, 59, 1, 15-22 Journal of Controlled Release, 59, 1, 15-22 1999/05/01 英語 公開
Y. Yabe; M. Nishikawa; A. Tamada; Y. Takakura; M. Hashida Y. Yabe; M. Nishikawa; A. Tamada; Y. Takakura; M. Hashida Y. Yabe; M. Nishikawa; A. Tamada; Y. Takakura; M. Hashida Targeted delivery and improved therapeutic potential of catalase by chemical modification: Combination with superoxide dismutase derivatives Targeted delivery and improved therapeutic potential of catalase by chemical modification: Combination with superoxide dismutase derivatives Targeted delivery and improved therapeutic potential of catalase by chemical modification: Combination with superoxide dismutase derivatives Journal of Pharmacology and Experimental Therapeutics, 289, 2, 1176-1184 Journal of Pharmacology and Experimental Therapeutics, 289, 2, 1176-1184 Journal of Pharmacology and Experimental Therapeutics, 289, 2, 1176-1184 1999/05 英語 公開
F. Staud; M. Nishikawa; Y. Takakura; M. Hashida F. Staud; M. Nishikawa; Y. Takakura; M. Hashida F. Staud; M. Nishikawa; Y. Takakura; M. Hashida Liver uptake and hepato-biliary transfer of galactosylated proteins in rats are determined by the extent of galactosylation Liver uptake and hepato-biliary transfer of galactosylated proteins in rats are determined by the extent of galactosylation Liver uptake and hepato-biliary transfer of galactosylated proteins in rats are determined by the extent of galactosylation Biochimica et Biophysica Acta - General Subjects, 1427, 2, 183-192 Biochimica et Biophysica Acta - General Subjects, 1427, 2, 183-192 Biochimica et Biophysica Acta - General Subjects, 1427, 2, 183-192 1999/04/19 英語 公開
Y. Takakura; T. Takagi; M. Hashiguchi; M. Nishikawa; F. Yamashita; T. Doi; T. Imanishi; H. Suzuki; T. Kodama; M. Hashida Y. Takakura; T. Takagi; M. Hashiguchi; M. Nishikawa; F. Yamashita; T. Doi; T. Imanishi; H. Suzuki; T. Kodama; M. Hashida Y. Takakura; T. Takagi; M. Hashiguchi; M. Nishikawa; F. Yamashita; T. Doi; T. Imanishi; H. Suzuki; T. Kodama; M. Hashida Characterization of plasmid DNA binding and uptake by peritoneal macrophages from class A scavenger receptor knockout mice Characterization of plasmid DNA binding and uptake by peritoneal macrophages from class A scavenger receptor knockout mice Characterization of plasmid DNA binding and uptake by peritoneal macrophages from class A scavenger receptor knockout mice Pharmaceutical Research, 16, 4, 503-508 Pharmaceutical Research, 16, 4, 503-508 Pharmaceutical Research, 16, 4, 503-508 1999/04 英語 公開
H. Masuda; Y. Takakura; M. Hashida H. Masuda; Y. Takakura; M. Hashida H. Masuda; Y. Takakura; M. Hashida Pharmacokinetics and disposition characteristics of recombinant decorin after intravenous injection into mice Pharmacokinetics and disposition characteristics of recombinant decorin after intravenous injection into mice Pharmacokinetics and disposition characteristics of recombinant decorin after intravenous injection into mice Biochimica et Biophysica Acta - General Subjects, 1426, 3, 420-428 Biochimica et Biophysica Acta - General Subjects, 1426, 3, 420-428 Biochimica et Biophysica Acta - General Subjects, 1426, 3, 420-428 1999/02/02 英語 公開
M. Nishikawa; F. Staud; S. Takemura; Y. Takakura; M. Hashida M. Nishikawa; F. Staud; S. Takemura; Y. Takakura; M. Hashida M. Nishikawa; F. Staud; S. Takemura; Y. Takakura; M. Hashida Pharmacokinetic evaluation of biodistribution data obtained with radiolabeled proteins in mice Pharmacokinetic evaluation of biodistribution data obtained with radiolabeled proteins in mice Pharmacokinetic evaluation of biodistribution data obtained with radiolabeled proteins in mice Biological and Pharmaceutical Bulletin, 22, 2, 214-218 Biological and Pharmaceutical Bulletin, 22, 2, 214-218 Biological and Pharmaceutical Bulletin, 22, 2, 214-218 1999/02 英語 公開
S. Okamoto; K. Nakanishi; Y. Watanabe; F. Yamashita; Y. Takakura; M. Hashida S. Okamoto; K. Nakanishi; Y. Watanabe; F. Yamashita; Y. Takakura; M. Hashida S. Okamoto; K. Nakanishi; Y. Watanabe; F. Yamashita; Y. Takakura; M. Hashida Stimulation side-dependent asymmetrical secretion of poly I:poly C-induced interferon-β from polarized epithelial cell lines Stimulation side-dependent asymmetrical secretion of poly I:poly C-induced interferon-β from polarized epithelial cell lines Stimulation side-dependent asymmetrical secretion of poly I:poly C-induced interferon-β from polarized epithelial cell lines Biochemical and Biophysical Research Communications, 254, 1, 5-9 Biochemical and Biophysical Research Communications, 254, 1, 5-9 Biochemical and Biophysical Research Communications, 254, 1, 5-9 1999/01/08 英語 公開
H. Yura; N. Yoshimura; T. Hamashima; K. Akamatsu; M. Nishikawa; Y. Takakura; M. Hashida H. Yura; N. Yoshimura; T. Hamashima; K. Akamatsu; M. Nishikawa; Y. Takakura; M. Hashida H. Yura; N. Yoshimura; T. Hamashima; K. Akamatsu; M. Nishikawa; Y. Takakura; M. Hashida Synthesis and pharmacokinetics of a novel macromolecular prodrug of Tacrolimus (FK506), FK506-dextran conjugate Synthesis and pharmacokinetics of a novel macromolecular prodrug of Tacrolimus (FK506), FK506-dextran conjugate Synthesis and pharmacokinetics of a novel macromolecular prodrug of Tacrolimus (FK506), FK506-dextran conjugate Journal of Controlled Release, 57, 1, 87-99 Journal of Controlled Release, 57, 1, 87-99 Journal of Controlled Release, 57, 1, 87-99 1999/01/04 英語 公開
T. Nomura; K. Yasuda; T. Yamada; S. Okamoto; R.I. Mahato; Y. Watanabe; Y. Takakura; M. Hashida T. Nomura; K. Yasuda; T. Yamada; S. Okamoto; R.I. Mahato; Y. Watanabe; Y. Takakura; M. Hashida T. Nomura; K. Yasuda; T. Yamada; S. Okamoto; R.I. Mahato; Y. Watanabe; Y. Takakura; M. Hashida Gene expression and antitumor effects following direct interferon (IFN)-γ gene transfer with naked plasmid DNA and DC-chol liposome complexes in mice Gene expression and antitumor effects following direct interferon (IFN)-γ gene transfer with naked plasmid DNA and DC-chol liposome complexes in mice Gene expression and antitumor effects following direct interferon (IFN)-γ gene transfer with naked plasmid DNA and DC-chol liposome complexes in mice Gene Therapy, 6, 1, 121-129 Gene Therapy, 6, 1, 121-129 Gene Therapy, 6, 1, 121-129 1999/01 英語 公開
K.-I. Ogawara; M. Yoshida; Y. Takakura; M. Hashida; K. Higaki; T. Kimura K.-I. Ogawara; M. Yoshida; Y. Takakura; M. Hashida; K. Higaki; T. Kimura K.-I. Ogawara; M. Yoshida; Y. Takakura; M. Hashida; K. Higaki; T. Kimura Interaction of polystyrene microspheres with liver cells: Roles of membrane receptors and serum proteins Interaction of polystyrene microspheres with liver cells: Roles of membrane receptors and serum proteins Interaction of polystyrene microspheres with liver cells: Roles of membrane receptors and serum proteins Biochimica et Biophysica Acta - General Subjects, 1472, 1/2, 165-172 Biochimica et Biophysica Acta - General Subjects, 1472, 1/2, 165-172 Biochimica et Biophysica Acta - General Subjects, 1472, 1/2, 165-172 1999 英語 公開
Y. Yabe; Y. Koyama; M. Nishikawa; Y. Takakura; M. Hashida Y. Yabe; Y. Koyama; M. Nishikawa; Y. Takakura; M. Hashida Y. Yabe; Y. Koyama; M. Nishikawa; Y. Takakura; M. Hashida Hepatocyte-specific distribution of catalase and its inhibitory effect on hepatic ischemia/reperfusion injury in mice Hepatocyte-specific distribution of catalase and its inhibitory effect on hepatic ischemia/reperfusion injury in mice Hepatocyte-specific distribution of catalase and its inhibitory effect on hepatic ischemia/reperfusion injury in mice Free Radical Research, 30, 4, 265-274 Free Radical Research, 30, 4, 265-274 Free Radical Research, 30, 4, 265-274 1999 英語 公開
K.-I. Ogawara; S. Hasegawa; M. Nishikawa; Y. Takakura; M. Hashida K.-I. Ogawara; S. Hasegawa; M. Nishikawa; Y. Takakura; M. Hashida K.-I. Ogawara; S. Hasegawa; M. Nishikawa; Y. Takakura; M. Hashida Pharmacokinetic evaluation of mannosylated bovine serum albumin as a liver cell-specific carrier: Quantitative comparison with other hepatotropic ligands Pharmacokinetic evaluation of mannosylated bovine serum albumin as a liver cell-specific carrier: Quantitative comparison with other hepatotropic ligands Pharmacokinetic evaluation of mannosylated bovine serum albumin as a liver cell-specific carrier: Quantitative comparison with other hepatotropic ligands Journal of Drug Targeting, 6, 5, 349-360 Journal of Drug Targeting, 6, 5, 349-360 Journal of Drug Targeting, 6, 5, 349-360 1999 英語 公開
Mitsuru Hashida; Makiya Nishikawa; Fumiyoshi Yamashita; Yoshinobu Takakura Mitsuru Hashida; Makiya Nishikawa; Fumiyoshi Yamashita; Yoshinobu Takakura Mitsuru Hashida; Makiya Nishikawa; Fumiyoshi Yamashita; Yoshinobu Takakura Cell specific targeting of drugs and genes with glycosylated liposomes Cell specific targeting of drugs and genes with glycosylated liposomes Cell specific targeting of drugs and genes with glycosylated liposomes American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, 40, 1, 297-298 American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, 40, 1, 297-298 American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, 40, 1, 297-298 1999 英語 公開
K.-I. Ogawara; M. Yoshida; K. Furumoto; Y. Takakura; M. Hashida; K. Higaki; T. Kimura K.-I. Ogawara; M. Yoshida; K. Furumoto; Y. Takakura; M. Hashida; K. Higaki; T. Kimura K.-I. Ogawara; M. Yoshida; K. Furumoto; Y. Takakura; M. Hashida; K. Higaki; T. Kimura Uptake by hepatocytes and biliary excretion of intravenously administered polystyrene microspheres in rats Uptake by hepatocytes and biliary excretion of intravenously administered polystyrene microspheres in rats Uptake by hepatocytes and biliary excretion of intravenously administered polystyrene microspheres in rats Journal of Drug Targeting, 7, 3, 213-221 Journal of Drug Targeting, 7, 3, 213-221 Journal of Drug Targeting, 7, 3, 213-221 1999 英語 公開
S. Kawakami; F. Yamashita; M. Nishikawa; Y. Takakura; M. Hashida S. Kawakami; F. Yamashita; M. Nishikawa; Y. Takakura; M. Hashida S. Kawakami; F. Yamashita; M. Nishikawa; Y. Takakura; M. Hashida Asialoglycoprotein receptor-mediated gene transfer using novel galactosylated cationic liposomes Asialoglycoprotein receptor-mediated gene transfer using novel galactosylated cationic liposomes Asialoglycoprotein receptor-mediated gene transfer using novel galactosylated cationic liposomes Biochemical and Biophysical Research Communications, 252, 1, 78-83 Biochemical and Biophysical Research Communications, 252, 1, 78-83 Biochemical and Biophysical Research Communications, 252, 1, 78-83 1998/11/09 英語 公開
M. Nishikawa; S. Takemura; Y. Takakura; M. Hashida M. Nishikawa; S. Takemura; Y. Takakura; M. Hashida M. Nishikawa; S. Takemura; Y. Takakura; M. Hashida Targeted delivery of plasmid DNA to hepatocytes in vivo: Optimization of the pharmacokinetics of plasmid DNA/galactosylated poly(L-lysine) complexes by controlling their physicochemical properties Targeted delivery of plasmid DNA to hepatocytes in vivo: Optimization of the pharmacokinetics of plasmid DNA/galactosylated poly(L-lysine) complexes by controlling their physicochemical properties Targeted delivery of plasmid DNA to hepatocytes in vivo: Optimization of the pharmacokinetics of plasmid DNA/galactosylated poly(L-lysine) complexes by controlling their physicochemical properties Journal of Pharmacology and Experimental Therapeutics, 287, 1, 408-415 Journal of Pharmacology and Experimental Therapeutics, 287, 1, 408-415 Journal of Pharmacology and Experimental Therapeutics, 287, 1, 408-415 1998/10 英語 公開
S. Okamoto; Y. Watanabe; Y. Takakura; M. Hashida S. Okamoto; Y. Watanabe; Y. Takakura; M. Hashida S. Okamoto; Y. Watanabe; Y. Takakura; M. Hashida Cationic liposome-mediated efficient induction of type I interferons by a low dose of poly I:poly C in mouse cell lines Cationic liposome-mediated efficient induction of type I interferons by a low dose of poly I:poly C in mouse cell lines Cationic liposome-mediated efficient induction of type I interferons by a low dose of poly I:poly C in mouse cell lines Journal of Biochemistry, 124, 4, 697-701 Journal of Biochemistry, 124, 4, 697-701 Journal of Biochemistry, 124, 4, 697-701 1998/10 英語 公開
M. Hashida; S. Takemura; M. Nishikawa; Y. Takakura M. Hashida; S. Takemura; M. Nishikawa; Y. Takakura M. Hashida; S. Takemura; M. Nishikawa; Y. Takakura Targeted delivery of plasmid DNA complexed with galactosylated poly(L- lysine) Targeted delivery of plasmid DNA complexed with galactosylated poly(L- lysine) Targeted delivery of plasmid DNA complexed with galactosylated poly(L- lysine) Journal of Controlled Release, 53, 1/3, 301-310 Journal of Controlled Release, 53, 1/3, 301-310 Journal of Controlled Release, 53, 1/3, 301-310 1998/04/30 英語 公開
T. Takagi; M. Hashiguchi; R.I. Mahato; H. Tokuda; Y. Takakura; M. Hashida T. Takagi; M. Hashiguchi; R.I. Mahato; H. Tokuda; Y. Takakura; M. Hashida T. Takagi; M. Hashiguchi; R.I. Mahato; H. Tokuda; Y. Takakura; M. Hashida Involvement of specific mechanism in plasmid DNA uptake by mouse peritoneal macrophages Involvement of specific mechanism in plasmid DNA uptake by mouse peritoneal macrophages Involvement of specific mechanism in plasmid DNA uptake by mouse peritoneal macrophages Biochemical and Biophysical Research Communications, 245, 3, 729-733 Biochemical and Biophysical Research Communications, 245, 3, 729-733 Biochemical and Biophysical Research Communications, 245, 3, 729-733 1998/04/28 英語 公開
M. Nakamura; P. Davila-Zavala; H. Tokuda; Y. Takakura; M. Hashida M. Nakamura; P. Davila-Zavala; H. Tokuda; Y. Takakura; M. Hashida M. Nakamura; P. Davila-Zavala; H. Tokuda; Y. Takakura; M. Hashida Uptake and gene expression of naked plasmid DNA in cultured brain microvessel endothelial cells Uptake and gene expression of naked plasmid DNA in cultured brain microvessel endothelial cells Uptake and gene expression of naked plasmid DNA in cultured brain microvessel endothelial cells Biochemical and Biophysical Research Communications, 245, 1, 235-239 Biochemical and Biophysical Research Communications, 245, 1, 235-239 Biochemical and Biophysical Research Communications, 245, 1, 235-239 1998/04/07 英語 公開
Y. Takakura; Y. Oka; M. Hashida Y. Takakura; Y. Oka; M. Hashida Y. Takakura; Y. Oka; M. Hashida Cellular uptake properties of oligonucleotides in LLC-PK<sub>1</sub> renal epithelial cells Cellular uptake properties of oligonucleotides in LLC-PK<sub>1</sub> renal epithelial cells Cellular uptake properties of oligonucleotides in LLC-PK<sub>1</sub> renal epithelial cells Antisense and Nucleic Acid Drug Development, 8, 1, 67-73 Antisense and Nucleic Acid Drug Development, 8, 1, 67-73 Antisense and Nucleic Acid Drug Development, 8, 1, 67-73 1998/02 英語 公開
K.-I. Ogawara; M. Nishikawa; Y. Takakura; M. Hashida K.-I. Ogawara; M. Nishikawa; Y. Takakura; M. Hashida K.-I. Ogawara; M. Nishikawa; Y. Takakura; M. Hashida Pharmacokinetic analysis of hepatic uptake of galactosylated bovine serum albumin in a perfused rat liver Pharmacokinetic analysis of hepatic uptake of galactosylated bovine serum albumin in a perfused rat liver Pharmacokinetic analysis of hepatic uptake of galactosylated bovine serum albumin in a perfused rat liver Journal of Controlled Release, 50, 1/3, 309-317 Journal of Controlled Release, 50, 1/3, 309-317 Journal of Controlled Release, 50, 1/3, 309-317 1998/01/02 英語 公開
T. Nomura; N. Koreeda; F. Yamashita; Y. Takakura; M. Hashida T. Nomura; N. Koreeda; F. Yamashita; Y. Takakura; M. Hashida T. Nomura; N. Koreeda; F. Yamashita; Y. Takakura; M. Hashida Effect of particle size and charge on the disposition of lipid carriers after intratumoral injection into tissue-isolated tumors Effect of particle size and charge on the disposition of lipid carriers after intratumoral injection into tissue-isolated tumors Effect of particle size and charge on the disposition of lipid carriers after intratumoral injection into tissue-isolated tumors Pharmaceutical Research, 15, 1, 128-132 Pharmaceutical Research, 15, 1, 128-132 Pharmaceutical Research, 15, 1, 128-132 1998/01 英語 公開
T. Kanamaru; T. Takagi; Y. Takakura; M. Hashida T. Kanamaru; T. Takagi; Y. Takakura; M. Hashida T. Kanamaru; T. Takagi; Y. Takakura; M. Hashida Biological effects and cellular uptake of c-myc antisense oligonucleotides and their cationic liposome complexes Biological effects and cellular uptake of c-myc antisense oligonucleotides and their cationic liposome complexes Biological effects and cellular uptake of c-myc antisense oligonucleotides and their cationic liposome complexes Journal of Drug Targeting, 5, 4, 235-245 Journal of Drug Targeting, 5, 4, 235-245 Journal of Drug Targeting, 5, 4, 235-245 1998 英語 公開
Y. Takakura; R.I. Mahato; M. Hashida Y. Takakura; R.I. Mahato; M. Hashida Y. Takakura; R.I. Mahato; M. Hashida Extravasation of macromolecules Extravasation of macromolecules Extravasation of macromolecules Advanced Drug Delivery Reviews, 34, 1, 93-108 Advanced Drug Delivery Reviews, 34, 1, 93-108 Advanced Drug Delivery Reviews, 34, 1, 93-108 1998 英語 公開
K. Akamatsu; M. Imai; Y. Yamasaki; M. Nishikawa; Y. Takakura; M. Hashida K. Akamatsu; M. Imai; Y. Yamasaki; M. Nishikawa; Y. Takakura; M. Hashida K. Akamatsu; M. Imai; Y. Yamasaki; M. Nishikawa; Y. Takakura; M. Hashida Disposition characteristics of glycosylated poly(amino acids) as liver cell-specific drug carrier Disposition characteristics of glycosylated poly(amino acids) as liver cell-specific drug carrier Disposition characteristics of glycosylated poly(amino acids) as liver cell-specific drug carrier Journal of Drug Targeting, 6, 3, 229-239 Journal of Drug Targeting, 6, 3, 229-239 Journal of Drug Targeting, 6, 3, 229-239 1998 英語 公開
T. Takino; N. Koreeda; T. Nomura; T. Sakaeda; F. Yamashita; Y. Takakura; M. Hashida T. Takino; N. Koreeda; T. Nomura; T. Sakaeda; F. Yamashita; Y. Takakura; M. Hashida T. Takino; N. Koreeda; T. Nomura; T. Sakaeda; F. Yamashita; Y. Takakura; M. Hashida Control of plasma cholesterol-lowering action of probucol with various lipid carrier systems Control of plasma cholesterol-lowering action of probucol with various lipid carrier systems Control of plasma cholesterol-lowering action of probucol with various lipid carrier systems Biological and Pharmaceutical Bulletin, 21, 5, 492-497 Biological and Pharmaceutical Bulletin, 21, 5, 492-497 Biological and Pharmaceutical Bulletin, 21, 5, 492-497 1998 英語 公開
Y. Takakura Y. Takakura Y. Takakura Drug delivery systems in gene therapy Drug delivery systems in gene therapy Drug delivery systems in gene therapy Nippon rinsho. Japanese journal of clinical medicine, 56, 3, 691-695 Nippon rinsho. Japanese journal of clinical medicine, 56, 3, 691-695 Nippon rinsho. Japanese journal of clinical medicine, 56, 3, 691-695 1998 英語 公開
A. Takagi; Y. Yabe; M. Yoshida; Y. Takakura; M. Hashida A. Takagi; Y. Yabe; M. Yoshida; Y. Takakura; M. Hashida A. Takagi; Y. Yabe; M. Yoshida; Y. Takakura; M. Hashida Hepatic disposition characteristics of recombinant human interleukin-11 (rhIL-11) in the perfused rat liver Hepatic disposition characteristics of recombinant human interleukin-11 (rhIL-11) in the perfused rat liver Hepatic disposition characteristics of recombinant human interleukin-11 (rhIL-11) in the perfused rat liver Biological and Pharmaceutical Bulletin, 21, 12, 1364-1366 Biological and Pharmaceutical Bulletin, 21, 12, 1364-1366 Biological and Pharmaceutical Bulletin, 21, 12, 1364-1366 1998 英語 公開
K. Akamatsu; M. Nishikawa; Y. Takakura; M. Hashida K. Akamatsu; M. Nishikawa; Y. Takakura; M. Hashida K. Akamatsu; M. Nishikawa; Y. Takakura; M. Hashida Synthesis and biodistribution study of liver-specific prostaglandin E<sub>1</sub> polymeric conjugate Synthesis and biodistribution study of liver-specific prostaglandin E<sub>1</sub> polymeric conjugate Synthesis and biodistribution study of liver-specific prostaglandin E<sub>1</sub> polymeric conjugate International Journal of Pharmaceutics, 155, 1, 65-74 International Journal of Pharmaceutics, 155, 1, 65-74 International Journal of Pharmaceutics, 155, 1, 65-74 1997/09/12 英語 公開
M. Hashida; H. Hirabayashi; M. Nishikawa; Y. Takakura M. Hashida; H. Hirabayashi; M. Nishikawa; Y. Takakura M. Hashida; H. Hirabayashi; M. Nishikawa; Y. Takakura Targeted delivery of drugs and proteins to the liver via receptor-mediated endocytosis Targeted delivery of drugs and proteins to the liver via receptor-mediated endocytosis Targeted delivery of drugs and proteins to the liver via receptor-mediated endocytosis Journal of Controlled Release, 46, 1/2, 129-137 Journal of Controlled Release, 46, 1/2, 129-137 Journal of Controlled Release, 46, 1/2, 129-137 1997/05/05 英語 公開
T. Takagi; M. Kitano; S. Masuda; H. Tokuda; Y. Takakura; M. Hashida T. Takagi; M. Kitano; S. Masuda; H. Tokuda; Y. Takakura; M. Hashida T. Takagi; M. Kitano; S. Masuda; H. Tokuda; Y. Takakura; M. Hashida Augmented inhibitory effect of superoxide dismutase on superoxide anion release from macrophages by direct cationization Augmented inhibitory effect of superoxide dismutase on superoxide anion release from macrophages by direct cationization Augmented inhibitory effect of superoxide dismutase on superoxide anion release from macrophages by direct cationization Biochimica et Biophysica Acta - General Subjects, 1335, 1/2, 91-98 Biochimica et Biophysica Acta - General Subjects, 1335, 1/2, 91-98 Biochimica et Biophysica Acta - General Subjects, 1335, 1/2, 91-98 1997/04/17 英語 公開
K. Kawabata; M. Kondo; Y. Watanabe; Y. Takakura; M. Hashida K. Kawabata; M. Kondo; Y. Watanabe; Y. Takakura; M. Hashida K. Kawabata; M. Kondo; Y. Watanabe; Y. Takakura; M. Hashida Non-polarized secretion of mouse interferon-β from gene-transferred human intestinal Caco-2 cells Non-polarized secretion of mouse interferon-β from gene-transferred human intestinal Caco-2 cells Non-polarized secretion of mouse interferon-β from gene-transferred human intestinal Caco-2 cells Pharmaceutical Research, 14, 4, 483-485 Pharmaceutical Research, 14, 4, 483-485 Pharmaceutical Research, 14, 4, 483-485 1997/04 英語 公開
R.I. Mahato; S. Takemura; K. Akamatsu; M. Nishikawa; Y. Takakura; M. Hashida R.I. Mahato; S. Takemura; K. Akamatsu; M. Nishikawa; Y. Takakura; M. Hashida R.I. Mahato; S. Takemura; K. Akamatsu; M. Nishikawa; Y. Takakura; M. Hashida Physicochemical and disposition characteristics of antisense oligonucleotides complexed with glycosylated poly(L-lysine) Physicochemical and disposition characteristics of antisense oligonucleotides complexed with glycosylated poly(L-lysine) Physicochemical and disposition characteristics of antisense oligonucleotides complexed with glycosylated poly(L-lysine) Biochemical Pharmacology, 53, 6, 887-895 Biochemical Pharmacology, 53, 6, 887-895 Biochemical Pharmacology, 53, 6, 887-895 1997/03/21 英語 公開
K. Kawabata; S. Okamoto; Y. Takakura; M. Hashida; T. Hashimura; Y. Watanabe K. Kawabata; S. Okamoto; Y. Takakura; M. Hashida; T. Hashimura; Y. Watanabe K. Kawabata; S. Okamoto; Y. Takakura; M. Hashida; T. Hashimura; Y. Watanabe A physiological role of interferon (IFN)-β derived from tumor: Tumor growth of a mouse bladder carcinoma line MBT-2 is partially suppressed by autocrine IFN-β A physiological role of interferon (IFN)-β derived from tumor: Tumor growth of a mouse bladder carcinoma line MBT-2 is partially suppressed by autocrine IFN-β A physiological role of interferon (IFN)-β derived from tumor: Tumor growth of a mouse bladder carcinoma line MBT-2 is partially suppressed by autocrine IFN-β Cancer Letters, 113, 1-2, 159-164 Cancer Letters, 113, 1-2, 159-164 Cancer Letters, 113, 1-2, 159-164 1997/02/26 英語 公開
R.I. Mahato; Y. Takakura; M. Hashida R.I. Mahato; Y. Takakura; M. Hashida R.I. Mahato; Y. Takakura; M. Hashida Development of targeted delivery systems for nucleic acid drugs Development of targeted delivery systems for nucleic acid drugs Development of targeted delivery systems for nucleic acid drugs Journal of Drug Targeting, 4, 6, 337-357 Journal of Drug Targeting, 4, 6, 337-357 Journal of Drug Targeting, 4, 6, 337-357 1997 英語 公開
H. Furitsu; K.-I. Ogawara; T. Fujita; F. Yamashita; Y. Takakura; H. Sezaki; M. Hashida H. Furitsu; K.-I. Ogawara; T. Fujita; F. Yamashita; Y. Takakura; H. Sezaki; M. Hashida H. Furitsu; K.-I. Ogawara; T. Fujita; F. Yamashita; Y. Takakura; H. Sezaki; M. Hashida Pharmacokinetic analysis of scavenger receptor-mediated uptake of anionized proteins in the isolated perfused rat liver Pharmacokinetic analysis of scavenger receptor-mediated uptake of anionized proteins in the isolated perfused rat liver Pharmacokinetic analysis of scavenger receptor-mediated uptake of anionized proteins in the isolated perfused rat liver International Journal of Pharmaceutics, 151, 1, 15-26 International Journal of Pharmaceutics, 151, 1, 15-26 International Journal of Pharmaceutics, 151, 1, 15-26 1997 英語 公開
H. Bando; S. Mohri; F. Yamashita; Y. Takakura; M. Hashida H. Bando; S. Mohri; F. Yamashita; Y. Takakura; M. Hashida H. Bando; S. Mohri; F. Yamashita; Y. Takakura; M. Hashida Effects of skin metabolism on percutaneous penetration of lipophilic drugs Effects of skin metabolism on percutaneous penetration of lipophilic drugs Effects of skin metabolism on percutaneous penetration of lipophilic drugs Journal of Pharmaceutical Sciences, 86, 6, 759-761 Journal of Pharmaceutical Sciences, 86, 6, 759-761 Journal of Pharmaceutical Sciences, 86, 6, 759-761 1997 英語 公開
H. Bando; M. Sahashi; F. Yamashita; Y. Takakura; M. Hashida H. Bando; M. Sahashi; F. Yamashita; Y. Takakura; M. Hashida H. Bando; M. Sahashi; F. Yamashita; Y. Takakura; M. Hashida In vivo evaluation of acyclovir prodrug penetration and metabolism through rat skin using a diffusion/bioconversion model In vivo evaluation of acyclovir prodrug penetration and metabolism through rat skin using a diffusion/bioconversion model In vivo evaluation of acyclovir prodrug penetration and metabolism through rat skin using a diffusion/bioconversion model Pharmaceutical Research, 14, 1, 56-62 Pharmaceutical Research, 14, 1, 56-62 Pharmaceutical Research, 14, 1, 56-62 1997 英語 公開
A. Takagi; Y. Yabe; Y. Oka; K. Sawai; Y. Takakura; M. Hashida A. Takagi; Y. Yabe; Y. Oka; K. Sawai; Y. Takakura; M. Hashida A. Takagi; Y. Yabe; Y. Oka; K. Sawai; Y. Takakura; M. Hashida Renal disposition of recombinant human interleukin-11 in the isolated perfused rat kidney Renal disposition of recombinant human interleukin-11 in the isolated perfused rat kidney Renal disposition of recombinant human interleukin-11 in the isolated perfused rat kidney Pharmaceutical Research, 14, 1, 86-90 Pharmaceutical Research, 14, 1, 86-90 Pharmaceutical Research, 14, 1, 86-90 1997 英語 公開
T. Nomura; S. Nakajima; K. Kawabata; F. Yamashita; Y. Takakura; M. Hashida T. Nomura; S. Nakajima; K. Kawabata; F. Yamashita; Y. Takakura; M. Hashida T. Nomura; S. Nakajima; K. Kawabata; F. Yamashita; Y. Takakura; M. Hashida Intratumoral pharmacokinetics and in vivo gene expression of naked plasmid DNA and its cationic liposome complexes after direct gene transfer Intratumoral pharmacokinetics and in vivo gene expression of naked plasmid DNA and its cationic liposome complexes after direct gene transfer Intratumoral pharmacokinetics and in vivo gene expression of naked plasmid DNA and its cationic liposome complexes after direct gene transfer Cancer Research, 57, 13, 2681-2686 Cancer Research, 57, 13, 2681-2686 Cancer Research, 57, 13, 2681-2686 1997 英語 公開
T. Nomura; Y. Takakura; M. Hashida T. Nomura; Y. Takakura; M. Hashida T. Nomura; Y. Takakura; M. Hashida Cancer gene therapy by direct intratumoral injection: Gene expression and intratumoral pharmacokinetics of plasmid dna Cancer gene therapy by direct intratumoral injection: Gene expression and intratumoral pharmacokinetics of plasmid dna Cancer gene therapy by direct intratumoral injection: Gene expression and intratumoral pharmacokinetics of plasmid dna Japanese Journal of Cancer and Chemotherapy, 24, 4, 483-488 Japanese Journal of Cancer and Chemotherapy, 24, 4, 483-488 Japanese Journal of Cancer and Chemotherapy, 24, 4, 483-488 1997 英語 公開
R.I. Mahato; Y. Takakura; M. Hashida R.I. Mahato; Y. Takakura; M. Hashida R.I. Mahato; Y. Takakura; M. Hashida Nonviral vectors for in vivo gene delivery: Physicochemical and pharmacokinetic considerations Nonviral vectors for in vivo gene delivery: Physicochemical and pharmacokinetic considerations Nonviral vectors for in vivo gene delivery: Physicochemical and pharmacokinetic considerations Critical Reviews in Therapeutic Drug Carrier Systems, 14, 2, 133-172 Critical Reviews in Therapeutic Drug Carrier Systems, 14, 2, 133-172 Critical Reviews in Therapeutic Drug Carrier Systems, 14, 2, 133-172 1997 英語 公開
H. Tokuda; H. Nagano; Y. Takakura; M. Hashida H. Tokuda; H. Nagano; Y. Takakura; M. Hashida H. Tokuda; H. Nagano; Y. Takakura; M. Hashida Uptake characteristics of anionized and cationized proteins in brain microvessel endothelial cells Uptake characteristics of anionized and cationized proteins in brain microvessel endothelial cells Uptake characteristics of anionized and cationized proteins in brain microvessel endothelial cells Pharmaceutical Sciences, 3, 3, 147-151 Pharmaceutical Sciences, 3, 3, 147-151 Pharmaceutical Sciences, 3, 3, 147-151 1997 英語 公開
A. Saikawa; T. Nomura; F. Yamashita; Y. Takakura; H. Sezaki; M. Hashida A. Saikawa; T. Nomura; F. Yamashita; Y. Takakura; H. Sezaki; M. Hashida A. Saikawa; T. Nomura; F. Yamashita; Y. Takakura; H. Sezaki; M. Hashida Pharmacokinetic analysis of drug disposition after intratumoral injection in a tissue-isolated tumor perfusion system Pharmacokinetic analysis of drug disposition after intratumoral injection in a tissue-isolated tumor perfusion system Pharmacokinetic analysis of drug disposition after intratumoral injection in a tissue-isolated tumor perfusion system Pharmaceutical Research, 13, 10, 1438-1444 Pharmaceutical Research, 13, 10, 1438-1444 Pharmaceutical Research, 13, 10, 1438-1444 1996/10 英語 公開
K. Sawai; R.I. Mahato; Y. Oka; Y. Takakura; M. Hashida K. Sawai; R.I. Mahato; Y. Oka; Y. Takakura; M. Hashida K. Sawai; R.I. Mahato; Y. Oka; Y. Takakura; M. Hashida Disposition of oligonucleotides in isolated perfused rat kidney: Involvement of scavenger receptors in their renal uptake Disposition of oligonucleotides in isolated perfused rat kidney: Involvement of scavenger receptors in their renal uptake Disposition of oligonucleotides in isolated perfused rat kidney: Involvement of scavenger receptors in their renal uptake Journal of Pharmacology and Experimental Therapeutics, 279, 1, 284-290 Journal of Pharmacology and Experimental Therapeutics, 279, 1, 284-290 Journal of Pharmacology and Experimental Therapeutics, 279, 1, 284-290 1996/10 英語 公開
M. Nishikawa; Y. Takakura; M. Hashida M. Nishikawa; Y. Takakura; M. Hashida M. Nishikawa; Y. Takakura; M. Hashida Pharmacokinetic evaluation of polymeric carriers Pharmacokinetic evaluation of polymeric carriers Pharmacokinetic evaluation of polymeric carriers Advanced Drug Delivery Reviews, 21, 2, 135-155 Advanced Drug Delivery Reviews, 21, 2, 135-155 Advanced Drug Delivery Reviews, 21, 2, 135-155 1996/09/16 英語 公開
M. Hashida; R.I. Mahato; K. Kawabata; T. Miyao; M. Nishikawa; Y. Takakura M. Hashida; R.I. Mahato; K. Kawabata; T. Miyao; M. Nishikawa; Y. Takakura M. Hashida; R.I. Mahato; K. Kawabata; T. Miyao; M. Nishikawa; Y. Takakura Pharmacokinetics and targeted delivery of proteins and genes Pharmacokinetics and targeted delivery of proteins and genes Pharmacokinetics and targeted delivery of proteins and genes Journal of Controlled Release, 41, 1/2, 91-97 Journal of Controlled Release, 41, 1/2, 91-97 Journal of Controlled Release, 41, 1/2, 91-97 1996/08 英語 公開
Y. Takakura; R.I. Mahato; M. Nishikawa; M. Hashida Y. Takakura; R.I. Mahato; M. Nishikawa; M. Hashida Y. Takakura; R.I. Mahato; M. Nishikawa; M. Hashida Control of pharmacokinetic profiles of drug-macromolecule conjugates Control of pharmacokinetic profiles of drug-macromolecule conjugates Control of pharmacokinetic profiles of drug-macromolecule conjugates Advanced Drug Delivery Reviews, 19, 3, 377-399 Advanced Drug Delivery Reviews, 19, 3, 377-399 Advanced Drug Delivery Reviews, 19, 3, 377-399 1996/06/12 英語 公開
H. Hirabayashi; M. Nishikawa; Y. Takakura; M. Hashida H. Hirabayashi; M. Nishikawa; Y. Takakura; M. Hashida H. Hirabayashi; M. Nishikawa; Y. Takakura; M. Hashida Development and pharmacokinetics of galactosylated poly-L-glutamic acid as a bisdegradable carrier for liver-specific drug delivery Development and pharmacokinetics of galactosylated poly-L-glutamic acid as a bisdegradable carrier for liver-specific drug delivery Development and pharmacokinetics of galactosylated poly-L-glutamic acid as a bisdegradable carrier for liver-specific drug delivery Pharmaceutical Research, 13, 6, 880-884 Pharmaceutical Research, 13, 6, 880-884 Pharmaceutical Research, 13, 6, 880-884 1996/06 英語 公開
H. Bando; T. Takagi; F. Yamashita; Y. Takakura; M. Hashida H. Bando; T. Takagi; F. Yamashita; Y. Takakura; M. Hashida H. Bando; T. Takagi; F. Yamashita; Y. Takakura; M. Hashida Theoretical design of prodrug-enhancer combination based on a skin diffusion model: Prediction of permeation of acyclovir prodrugs treated with 1-geranylazacycloheptan-2-one Theoretical design of prodrug-enhancer combination based on a skin diffusion model: Prediction of permeation of acyclovir prodrugs treated with 1-geranylazacycloheptan-2-one Theoretical design of prodrug-enhancer combination based on a skin diffusion model: Prediction of permeation of acyclovir prodrugs treated with 1-geranylazacycloheptan-2-one Pharmaceutical Research, 13, 3, 427-432 Pharmaceutical Research, 13, 3, 427-432 Pharmaceutical Research, 13, 3, 427-432 1996/03 英語 公開
Y. Takakura; R.I. Mahato; M. Yoshida; T. Kanamaru; M. Hashida Y. Takakura; R.I. Mahato; M. Yoshida; T. Kanamaru; M. Hashida Y. Takakura; R.I. Mahato; M. Yoshida; T. Kanamaru; M. Hashida Uptake characteristics of oligonucleotides in the isolated rat liver perfusion system Uptake characteristics of oligonucleotides in the isolated rat liver perfusion system Uptake characteristics of oligonucleotides in the isolated rat liver perfusion system Antisense and Nucleic Acid Drug Development, 6, 3, 177-183 Antisense and Nucleic Acid Drug Development, 6, 3, 177-183 Antisense and Nucleic Acid Drug Development, 6, 3, 177-183 1996 英語 公開
P.U. Jani; T. Nomura; F. Yamashita; Y. Takakura; A.T. Florence; M. Hashida P.U. Jani; T. Nomura; F. Yamashita; Y. Takakura; A.T. Florence; M. Hashida P.U. Jani; T. Nomura; F. Yamashita; Y. Takakura; A.T. Florence; M. Hashida Biliary excretion of polystyrene microspheres with covalently linked FITC fluorescence after oral and parenteral administration to male Wistar rats Biliary excretion of polystyrene microspheres with covalently linked FITC fluorescence after oral and parenteral administration to male Wistar rats Biliary excretion of polystyrene microspheres with covalently linked FITC fluorescence after oral and parenteral administration to male Wistar rats Journal of Drug Targeting, 4, 2, 87-93 Journal of Drug Targeting, 4, 2, 87-93 Journal of Drug Targeting, 4, 2, 87-93 1996 英語 公開
Y. Takakura; M. Hashida Y. Takakura; M. Hashida Y. Takakura; M. Hashida Macromolecular carrier systems for targeted drug delivery: Pharmacokinetic considerations on biodistribution Macromolecular carrier systems for targeted drug delivery: Pharmacokinetic considerations on biodistribution Macromolecular carrier systems for targeted drug delivery: Pharmacokinetic considerations on biodistribution Pharmaceutical Research, 13, 6, 820-831 Pharmaceutical Research, 13, 6, 820-831 Pharmaceutical Research, 13, 6, 820-831 1996 英語 公開
M. Yoshida; R.I. Mahato; K. Kawabata; Y. Takakura; M. Hashida M. Yoshida; R.I. Mahato; K. Kawabata; Y. Takakura; M. Hashida M. Yoshida; R.I. Mahato; K. Kawabata; Y. Takakura; M. Hashida Disposition characteristics of plasmid DNA in the single-pass rat liver perfusion system Disposition characteristics of plasmid DNA in the single-pass rat liver perfusion system Disposition characteristics of plasmid DNA in the single-pass rat liver perfusion system Pharmaceutical Research, 13, 4, 599-603 Pharmaceutical Research, 13, 4, 599-603 Pharmaceutical Research, 13, 4, 599-603 1996 英語 公開
H. Bando; M. Sahashi; S. Mohri; F. Yamashita; Y. Takakura; M. Hashida H. Bando; M. Sahashi; S. Mohri; F. Yamashita; Y. Takakura; M. Hashida H. Bando; M. Sahashi; S. Mohri; F. Yamashita; Y. Takakura; M. Hashida In vivo skin penetration enhancement of acyclovir by theoretical design of prodrug-enhancer combination In vivo skin penetration enhancement of acyclovir by theoretical design of prodrug-enhancer combination In vivo skin penetration enhancement of acyclovir by theoretical design of prodrug-enhancer combination International Journal of Pharmaceutics, 145, 1/2, 103-113 International Journal of Pharmaceutics, 145, 1/2, 103-113 International Journal of Pharmaceutics, 145, 1/2, 103-113 1996 英語 公開
H. Bando; M. Sahashi; T. Takagi; F. Yamashita; Y. Takakura; M. Hashida H. Bando; M. Sahashi; T. Takagi; F. Yamashita; Y. Takakura; M. Hashida H. Bando; M. Sahashi; T. Takagi; F. Yamashita; Y. Takakura; M. Hashida Analysis of in vitro skin penetration of acyclovir prodrugs based on a diffusion model with a metabolic process Analysis of in vitro skin penetration of acyclovir prodrugs based on a diffusion model with a metabolic process Analysis of in vitro skin penetration of acyclovir prodrugs based on a diffusion model with a metabolic process International Journal of Pharmaceutics, 135, 1/2, 91-102 International Journal of Pharmaceutics, 135, 1/2, 91-102 International Journal of Pharmaceutics, 135, 1/2, 91-102 1996 英語 公開
Y. Takakura; M. Hashida Y. Takakura; M. Hashida Y. Takakura; M. Hashida Delivery of plasmid DNA to endothelial cells Delivery of plasmid DNA to endothelial cells Delivery of plasmid DNA to endothelial cells European Journal of Pharmaceutics and Biopharmaceutics, 42, 4, 269-276 European Journal of Pharmaceutics and Biopharmaceutics, 42, 4, 269-276 European Journal of Pharmaceutics and Biopharmaceutics, 42, 4, 269-276 1996 英語 公開
Y. Takakura Y. Takakura Y. Takakura Development of drug delivery systems for macromolecular drugs Development of drug delivery systems for macromolecular drugs Development of drug delivery systems for macromolecular drugs Yakugaku Zasshi, 116, 7, 519-532 Yakugaku Zasshi, 116, 7, 519-532 Yakugaku Zasshi, 116, 7, 519-532 1996 英語 公開
M. Hashida; M. Nishikawa; Y. Takakura M. Hashida; M. Nishikawa; Y. Takakura M. Hashida; M. Nishikawa; Y. Takakura Hepatic targeting of drugs and proteins by chemical modification Hepatic targeting of drugs and proteins by chemical modification Hepatic targeting of drugs and proteins by chemical modification Journal of Controlled Release, 36, 1/2, 99-107 Journal of Controlled Release, 36, 1/2, 99-107 Journal of Controlled Release, 36, 1/2, 99-107 1995/09 英語 公開
NISHIKAWA, M; MIYAZAKI, C; YAMASHITA, F; TAKAKURA, Y; HASHIDA, M NISHIKAWA, M; MIYAZAKI, C; YAMASHITA, F; TAKAKURA, Y; HASHIDA, M NISHIKAWA, M; MIYAZAKI, C; YAMASHITA, F; TAKAKURA, Y; HASHIDA, M GALACTOSYLATED PROTEINS ARE RECOGNIZED BY THE LIVER ACCORDING TO THE SURFACE-DENSITY OF GALACTOSE MOIETIES GALACTOSYLATED PROTEINS ARE RECOGNIZED BY THE LIVER ACCORDING TO THE SURFACE-DENSITY OF GALACTOSE MOIETIES GALACTOSYLATED PROTEINS ARE RECOGNIZED BY THE LIVER ACCORDING TO THE SURFACE-DENSITY OF GALACTOSE MOIETIES AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 268, 5, G849-G856 AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 268, 5, G849-G856 AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 268, 5, G849-G856 1995/05 英語 公開
Y. Takakura; M. Hashida Y. Takakura; M. Hashida Y. Takakura; M. Hashida Macromolecular drug carrier systems in cancer chemotherapy: macromolecular prodrugs Macromolecular drug carrier systems in cancer chemotherapy: macromolecular prodrugs Macromolecular drug carrier systems in cancer chemotherapy: macromolecular prodrugs Critical Reviews in Oncology and Hematology, 18, 3, 207-231 Critical Reviews in Oncology and Hematology, 18, 3, 207-231 Critical Reviews in Oncology and Hematology, 18, 3, 207-231 1995/03 英語 公開
M. Nishikawa; H. Hirabayashi; Y. Takakura; M. Hashida M. Nishikawa; H. Hirabayashi; Y. Takakura; M. Hashida M. Nishikawa; H. Hirabayashi; Y. Takakura; M. Hashida Design for cell-specific targeting of proteins utilizing sugar-recognition mechanism: Effect of molecular weight of proteins on targeting efficiency Design for cell-specific targeting of proteins utilizing sugar-recognition mechanism: Effect of molecular weight of proteins on targeting efficiency Design for cell-specific targeting of proteins utilizing sugar-recognition mechanism: Effect of molecular weight of proteins on targeting efficiency Pharmaceutical Research, 12, 2, 209-214 Pharmaceutical Research, 12, 2, 209-214 Pharmaceutical Research, 12, 2, 209-214 1995/02 英語 公開
T. Miyao; Y. Takakura; T. Akiyama; F. Yoneda; H. Sezaki; M. Hashida T. Miyao; Y. Takakura; T. Akiyama; F. Yoneda; H. Sezaki; M. Hashida T. Miyao; Y. Takakura; T. Akiyama; F. Yoneda; H. Sezaki; M. Hashida Stability and pharmacokinetic characteristics of oligonucleotides modified at terminal linkages in mice Stability and pharmacokinetic characteristics of oligonucleotides modified at terminal linkages in mice Stability and pharmacokinetic characteristics of oligonucleotides modified at terminal linkages in mice Antisense Research and Development, 5, 2, 115-121 Antisense Research and Development, 5, 2, 115-121 Antisense Research and Development, 5, 2, 115-121 1995 英語 公開
R.I. Mahato; K. Kawabata; T. Nomura; Y. Takakura; M. Hashida R.I. Mahato; K. Kawabata; T. Nomura; Y. Takakura; M. Hashida R.I. Mahato; K. Kawabata; T. Nomura; Y. Takakura; M. Hashida Physicochemical and pharmacokinetic characteristics of plasmid DNA/cationic liposome complexes Physicochemical and pharmacokinetic characteristics of plasmid DNA/cationic liposome complexes Physicochemical and pharmacokinetic characteristics of plasmid DNA/cationic liposome complexes Journal of Pharmaceutical Sciences, 84, 11, 1267-1271 Journal of Pharmaceutical Sciences, 84, 11, 1267-1271 Journal of Pharmaceutical Sciences, 84, 11, 1267-1271 1995 英語 公開
F. Yamashita; Y. Koyama; m. Kitano; Y. Takakura; M. Hashida F. Yamashita; Y. Koyama; m. Kitano; Y. Takakura; M. Hashida F. Yamashita; Y. Koyama; m. Kitano; Y. Takakura; M. Hashida Analysis of in vivo skin penetration enhancement by oleic acid based on a two-layer diffusion model with polar and nonpolar routes in the stratum corneum Analysis of in vivo skin penetration enhancement by oleic acid based on a two-layer diffusion model with polar and nonpolar routes in the stratum corneum Analysis of in vivo skin penetration enhancement by oleic acid based on a two-layer diffusion model with polar and nonpolar routes in the stratum corneum International Journal of Pharmaceutics, 117, 2, 173-179 International Journal of Pharmaceutics, 117, 2, 173-179 International Journal of Pharmaceutics, 117, 2, 173-179 1995 英語 公開
T. Takino; E. Nagahama; T. Sakaeda(neeKakutani); F. Yamashita; Y. Takakura; M. Hashida T. Takino; E. Nagahama; T. Sakaeda(neeKakutani); F. Yamashita; Y. Takakura; M. Hashida T. Takino; E. Nagahama; T. Sakaeda(neeKakutani); F. Yamashita; Y. Takakura; M. Hashida Pharmacokinetic disposition analysis of lipophilic drugs injected with various lipid carriers in the single-pass rat liver perfusion system Pharmacokinetic disposition analysis of lipophilic drugs injected with various lipid carriers in the single-pass rat liver perfusion system Pharmacokinetic disposition analysis of lipophilic drugs injected with various lipid carriers in the single-pass rat liver perfusion system International Journal of Pharmaceutics, 114, 1, 43-54 International Journal of Pharmaceutics, 114, 1, 43-54 International Journal of Pharmaceutics, 114, 1, 43-54 1995 英語 公開
S. Choksakulnimitr; S. Masuda; H. Tokuda; Y. Takakura; M. Hashida S. Choksakulnimitr; S. Masuda; H. Tokuda; Y. Takakura; M. Hashida S. Choksakulnimitr; S. Masuda; H. Tokuda; Y. Takakura; M. Hashida In vitro cytotoxicity of macromolecules in different cell culture systems In vitro cytotoxicity of macromolecules in different cell culture systems In vitro cytotoxicity of macromolecules in different cell culture systems Journal of Controlled Release, 34, 3, 233-241 Journal of Controlled Release, 34, 3, 233-241 Journal of Controlled Release, 34, 3, 233-241 1995 英語 公開
K. Kawabata; Y. Takakura; M. Hashida K. Kawabata; Y. Takakura; M. Hashida K. Kawabata; Y. Takakura; M. Hashida The fate of plasmid DNA after intravenous injection in mice: Involvement of scavenger receptors in its hepatic uptake The fate of plasmid DNA after intravenous injection in mice: Involvement of scavenger receptors in its hepatic uptake The fate of plasmid DNA after intravenous injection in mice: Involvement of scavenger receptors in its hepatic uptake Pharmaceutical Research, 12, 6, 825-830 Pharmaceutical Research, 12, 6, 825-830 Pharmaceutical Research, 12, 6, 825-830 1995 英語 公開
R.I. Mahato; K. Kawabata; Y. Takakura; M. Hashida R.I. Mahato; K. Kawabata; Y. Takakura; M. Hashida R.I. Mahato; K. Kawabata; Y. Takakura; M. Hashida In vivo disposition characteristics of plasmid DNA complexed with cationic liposomes In vivo disposition characteristics of plasmid DNA complexed with cationic liposomes In vivo disposition characteristics of plasmid DNA complexed with cationic liposomes Journal of Drug Targeting, 3, 2, 149-157 Journal of Drug Targeting, 3, 2, 149-157 Journal of Drug Targeting, 3, 2, 149-157 1995 英語 公開
Y. Takakura; T. Morita; M. Fujikawa; M. Hayashi; H. Sezaki; M. Hashida; R.T. Borchardt Y. Takakura; T. Morita; M. Fujikawa; M. Hayashi; H. Sezaki; M. Hashida; R.T. Borchardt Y. Takakura; T. Morita; M. Fujikawa; M. Hayashi; H. Sezaki; M. Hashida; R.T. Borchardt Characterization of LLC-PK<sub>1</sub> kidney epithelial cells as an in vitro model for studying renal tubular reabsorption of protein drugs Characterization of LLC-PK<sub>1</sub> kidney epithelial cells as an in vitro model for studying renal tubular reabsorption of protein drugs Characterization of LLC-PK<sub>1</sub> kidney epithelial cells as an in vitro model for studying renal tubular reabsorption of protein drugs Pharmaceutical Research, 12, 12, 1968-1972 Pharmaceutical Research, 12, 12, 1968-1972 Pharmaceutical Research, 12, 12, 1968-1972 1995 英語 公開
A. Takagi; H. Masuda; Y. Takakura; M. Hashida A. Takagi; H. Masuda; Y. Takakura; M. Hashida A. Takagi; H. Masuda; Y. Takakura; M. Hashida Disposition characteristics of recombinant human interleukin-11 after a bolus intravenous administration in mice Disposition characteristics of recombinant human interleukin-11 after a bolus intravenous administration in mice Disposition characteristics of recombinant human interleukin-11 after a bolus intravenous administration in mice Journal of Pharmacology and Experimental Therapeutics, 275, 2, 537-543 Journal of Pharmacology and Experimental Therapeutics, 275, 2, 537-543 Journal of Pharmacology and Experimental Therapeutics, 275, 2, 537-543 1995 英語 公開
F. Yamashita; H. Bando; Y. Takakura; M. Hashida F. Yamashita; H. Bando; Y. Takakura; M. Hashida F. Yamashita; H. Bando; Y. Takakura; M. Hashida A deconvolution method for estimating the first-pass metabolism of orally administered drugs A deconvolution method for estimating the first-pass metabolism of orally administered drugs A deconvolution method for estimating the first-pass metabolism of orally administered drugs Biological and Pharmaceutical Bulletin, 18, 12, 1787-1789 Biological and Pharmaceutical Bulletin, 18, 12, 1787-1789 Biological and Pharmaceutical Bulletin, 18, 12, 1787-1789 1995 英語 公開
M. Hashida; Y. Takakura M. Hashida; Y. Takakura M. Hashida; Y. Takakura Pharmacokinetics in design of polymeric drug delivery systems Pharmacokinetics in design of polymeric drug delivery systems Pharmacokinetics in design of polymeric drug delivery systems Journal of Controlled Release, 31, 2, 163-171 Journal of Controlled Release, 31, 2, 163-171 Journal of Controlled Release, 31, 2, 163-171 1994/09 英語 公開
TAKAKURA, Y; FUJITA, T; FURITSU, H; NISHIKAWA, M; SEZAKI, H; HASHIDA, M TAKAKURA, Y; FUJITA, T; FURITSU, H; NISHIKAWA, M; SEZAKI, H; HASHIDA, M TAKAKURA, Y; FUJITA, T; FURITSU, H; NISHIKAWA, M; SEZAKI, H; HASHIDA, M PHARMACOKINETICS OF SUCCINYLATED PROTEINS AND DEXTRAN SULFATE IN MICE - IMPLICATIONS FOR HEPATIC TARGETING OF PROTEIN DRUGS BY DIRECT SUCCINYLATION VIA SCAVENGER RECEPTORS PHARMACOKINETICS OF SUCCINYLATED PROTEINS AND DEXTRAN SULFATE IN MICE - IMPLICATIONS FOR HEPATIC TARGETING OF PROTEIN DRUGS BY DIRECT SUCCINYLATION VIA SCAVENGER RECEPTORS PHARMACOKINETICS OF SUCCINYLATED PROTEINS AND DEXTRAN SULFATE IN MICE - IMPLICATIONS FOR HEPATIC TARGETING OF PROTEIN DRUGS BY DIRECT SUCCINYLATION VIA SCAVENGER RECEPTORS INTERNATIONAL JOURNAL OF PHARMACEUTICS, 105, 1, 19-29 INTERNATIONAL JOURNAL OF PHARMACEUTICS, 105, 1, 19-29 INTERNATIONAL JOURNAL OF PHARMACEUTICS, 105, 1, 19-29 1994/04/25 英語 公開
Y. Takakura; S. Masuda; H. Tokuda; M. Nishikawa; M. Hashida Y. Takakura; S. Masuda; H. Tokuda; M. Nishikawa; M. Hashida Y. Takakura; S. Masuda; H. Tokuda; M. Nishikawa; M. Hashida Targeted delivery of superoxide dismutase to macrophages via mannose receptor-mediated mechanism Targeted delivery of superoxide dismutase to macrophages via mannose receptor-mediated mechanism Targeted delivery of superoxide dismutase to macrophages via mannose receptor-mediated mechanism Biochemical Pharmacology, 47, 5, 853-858 Biochemical Pharmacology, 47, 5, 853-858 Biochemical Pharmacology, 47, 5, 853-858 1994/03/02 英語 公開
TAKAKURA, Y; MIHARA, K; HASHIDA, M TAKAKURA, Y; MIHARA, K; HASHIDA, M TAKAKURA, Y; MIHARA, K; HASHIDA, M CONTROL OF THE DISPOSITION PROFILES OF PROTEINS IN THE KIDNEY VIA CHEMICAL MODIFICATION CONTROL OF THE DISPOSITION PROFILES OF PROTEINS IN THE KIDNEY VIA CHEMICAL MODIFICATION CONTROL OF THE DISPOSITION PROFILES OF PROTEINS IN THE KIDNEY VIA CHEMICAL MODIFICATION JOURNAL OF CONTROLLED RELEASE, 28, 1/3, 111-119 JOURNAL OF CONTROLLED RELEASE, 28, 1/3, 111-119 JOURNAL OF CONTROLLED RELEASE, 28, 1/3, 111-119 1994/01 英語 公開
K. Mihara; Y. Oka; K. Sawai; Y. Takakura; M. Hashida K. Mihara; Y. Oka; K. Sawai; Y. Takakura; M. Hashida K. Mihara; Y. Oka; K. Sawai; Y. Takakura; M. Hashida Improvement of therapeutic effect of human recombinant superoxide dismutase on ischemic acute renal failure in the rat via cationization and conjugation with polyethylene glycol Improvement of therapeutic effect of human recombinant superoxide dismutase on ischemic acute renal failure in the rat via cationization and conjugation with polyethylene glycol Improvement of therapeutic effect of human recombinant superoxide dismutase on ischemic acute renal failure in the rat via cationization and conjugation with polyethylene glycol Journal of Drug Targeting, 2, 4, 317-321 Journal of Drug Targeting, 2, 4, 317-321 Journal of Drug Targeting, 2, 4, 317-321 1994 英語 公開
F. Yamashita; H. Bando; Y. Koyama; S. Kitagawa; Y. Takakura; M. Hashida F. Yamashita; H. Bando; Y. Koyama; S. Kitagawa; Y. Takakura; M. Hashida F. Yamashita; H. Bando; Y. Koyama; S. Kitagawa; Y. Takakura; M. Hashida In vivo and in vitro analysis of skin penetration enhancement based on a two-layer diffusion model with polar and nonpolar routes in the stratum corneum In vivo and in vitro analysis of skin penetration enhancement based on a two-layer diffusion model with polar and nonpolar routes in the stratum corneum In vivo and in vitro analysis of skin penetration enhancement based on a two-layer diffusion model with polar and nonpolar routes in the stratum corneum Pharmaceutical Research, 11, 2, 185-191 Pharmaceutical Research, 11, 2, 185-191 Pharmaceutical Research, 11, 2, 185-191 1994 英語 公開
T. Morita; A. Yamamoto; Y. Takakura; L.M. Hashida; H. Sezaki T. Morita; A. Yamamoto; Y. Takakura; L.M. Hashida; H. Sezaki T. Morita; A. Yamamoto; Y. Takakura; L.M. Hashida; H. Sezaki Improvement of the pulmonary absorption of (Asu<sup>1,7</sup>)-eel calcitonin by various protease inhibitors in rats Improvement of the pulmonary absorption of (Asu<sup>1,7</sup>)-eel calcitonin by various protease inhibitors in rats Improvement of the pulmonary absorption of (Asu<sup>1,7</sup>)-eel calcitonin by various protease inhibitors in rats Pharmaceutical Research, 11, 6, 909-913 Pharmaceutical Research, 11, 6, 909-913 Pharmaceutical Research, 11, 6, 909-913 1994 英語 公開
Y. Koyama; H. Bando; F. Yamashita; Y. Takakura; H. Sezaki; M. Hashida Y. Koyama; H. Bando; F. Yamashita; Y. Takakura; H. Sezaki; M. Hashida Y. Koyama; H. Bando; F. Yamashita; Y. Takakura; H. Sezaki; M. Hashida Comparative analysis of percutaneous absorption enhancement by d-limonene and oleic acid based on a skin diffusion model Comparative analysis of percutaneous absorption enhancement by d-limonene and oleic acid based on a skin diffusion model Comparative analysis of percutaneous absorption enhancement by d-limonene and oleic acid based on a skin diffusion model Pharmaceutical Research, 11, 3, 377-383 Pharmaceutical Research, 11, 3, 377-383 Pharmaceutical Research, 11, 3, 377-383 1994 英語 公開
M. Hashida; M. Nishikawa; F. Yamashita; Y. Takakura M. Hashida; M. Nishikawa; F. Yamashita; Y. Takakura M. Hashida; M. Nishikawa; F. Yamashita; Y. Takakura Targeting delivery of protein drugs by chemical modification Targeting delivery of protein drugs by chemical modification Targeting delivery of protein drugs by chemical modification Drug Development and Industrial Pharmacy, 20, 4, 581-590 Drug Development and Industrial Pharmacy, 20, 4, 581-590 Drug Development and Industrial Pharmacy, 20, 4, 581-590 1994 英語 公開
T. Fujita; M. Nishikawa; Y. Ohtsubo; J. Ohno; Y. Takakura; H. Sezaki; M. Hashida T. Fujita; M. Nishikawa; Y. Ohtsubo; J. Ohno; Y. Takakura; H. Sezaki; M. Hashida T. Fujita; M. Nishikawa; Y. Ohtsubo; J. Ohno; Y. Takakura; H. Sezaki; M. Hashida Control of in vivo fate of albumin derivatives utilizing combined chemical modification Control of in vivo fate of albumin derivatives utilizing combined chemical modification Control of in vivo fate of albumin derivatives utilizing combined chemical modification Journal of Drug Targeting, 2, 2, 157-165 Journal of Drug Targeting, 2, 2, 157-165 Journal of Drug Targeting, 2, 2, 157-165 1994 英語 公開
T. Takino; K. Konishi; Y. Takakura; M. Hashida T. Takino; K. Konishi; Y. Takakura; M. Hashida T. Takino; K. Konishi; Y. Takakura; M. Hashida Long circulating emulsion carrier systems for highly lipophilic drugs Long circulating emulsion carrier systems for highly lipophilic drugs Long circulating emulsion carrier systems for highly lipophilic drugs Biological and Pharmaceutical Bulletin, 17, 1, 121-125 Biological and Pharmaceutical Bulletin, 17, 1, 121-125 Biological and Pharmaceutical Bulletin, 17, 1, 121-125 1994 英語 公開
K. Mihara; K. Sawai; Y. Takakura; M. Hashida K. Mihara; K. Sawai; Y. Takakura; M. Hashida K. Mihara; K. Sawai; Y. Takakura; M. Hashida Manipulation of renal disposition of human recombinant superoxide dismutase by chemical modification Manipulation of renal disposition of human recombinant superoxide dismutase by chemical modification Manipulation of renal disposition of human recombinant superoxide dismutase by chemical modification Biological and Pharmaceutical Bulletin, 17, 2, 296-301 Biological and Pharmaceutical Bulletin, 17, 2, 296-301 Biological and Pharmaceutical Bulletin, 17, 2, 296-301 1994 英語 公開
Y. Takakura; T. Miyao; K. Kawabata; M. Hashida Y. Takakura; T. Miyao; K. Kawabata; M. Hashida Control of in vivo characteristics of gene and antisense DNA disposition Control of in vivo characteristics of gene and antisense DNA disposition Japanese Journal of Cancer and Chemotherapy, 21, 3, 320-324 Japanese Journal of Cancer and Chemotherapy, 21, 3, 320-324 , 21, 3, 320-324 1994 日本語 公開
H. Tokuda; S. Masuda; Y. Takakura; H. Sezaki; M. Hashida H. Tokuda; S. Masuda; Y. Takakura; H. Sezaki; M. Hashida H. Tokuda; S. Masuda; Y. Takakura; H. Sezaki; M. Hashida Specific uptake of succinylated proteins via a scavenger receptor-mediated mechanism in cultured brain microvessel endothelial cells Specific uptake of succinylated proteins via a scavenger receptor-mediated mechanism in cultured brain microvessel endothelial cells Specific uptake of succinylated proteins via a scavenger receptor-mediated mechanism in cultured brain microvessel endothelial cells Biochemical and Biophysical Research Communications, 196, 1, 18-24 Biochemical and Biophysical Research Communications, 196, 1, 18-24 Biochemical and Biophysical Research Communications, 196, 1, 18-24 1993/10/15 英語 公開
M. Nishikawa; A. Kamijo; T. Fujita; Y. Takakura; H. Sezaki; M. Hashida M. Nishikawa; A. Kamijo; T. Fujita; Y. Takakura; H. Sezaki; M. Hashida M. Nishikawa; A. Kamijo; T. Fujita; Y. Takakura; H. Sezaki; M. Hashida Synthesis and pharmacokinetics of a new liver-specific carrier, glycosylated carboxymethyl-dextran, and its application to drug targeting Synthesis and pharmacokinetics of a new liver-specific carrier, glycosylated carboxymethyl-dextran, and its application to drug targeting Synthesis and pharmacokinetics of a new liver-specific carrier, glycosylated carboxymethyl-dextran, and its application to drug targeting Pharmaceutical Research, 10, 9, 1253-1261 Pharmaceutical Research, 10, 9, 1253-1261 Pharmaceutical Research, 10, 9, 1253-1261 1993/09 英語 公開
K. Mihara; T. Hojo; M. Fujikawa; Y. Takakura; H. Sezaki; M. Hashida K. Mihara; T. Hojo; M. Fujikawa; Y. Takakura; H. Sezaki; M. Hashida K. Mihara; T. Hojo; M. Fujikawa; Y. Takakura; H. Sezaki; M. Hashida Disposition characteristics of protein drugs in the perfused rat kidney Disposition characteristics of protein drugs in the perfused rat kidney Disposition characteristics of protein drugs in the perfused rat kidney Pharmaceutical Research, 10, 6, 823-827 Pharmaceutical Research, 10, 6, 823-827 Pharmaceutical Research, 10, 6, 823-827 1993/06 英語 公開
T. Takino; C. Nakajima; Y. Takakura; H. Sezaki; M. Hashida T. Takino; C. Nakajima; Y. Takakura; H. Sezaki; M. Hashida T. Takino; C. Nakajima; Y. Takakura; H. Sezaki; M. Hashida Controlled biodistribution of highly lipophilic drugs with various parenteral formulations. Controlled biodistribution of highly lipophilic drugs with various parenteral formulations. Controlled biodistribution of highly lipophilic drugs with various parenteral formulations. Journal of drug targeting, 1, 2, 117-124 Journal of drug targeting, 1, 2, 117-124 Journal of drug targeting, 1, 2, 117-124 1993 英語 公開
T. Fujita; H. Furitsu; M. Nishikawa; Y. Takakura; H. Sezaki; M. Hashida T. Fujita; H. Furitsu; M. Nishikawa; Y. Takakura; H. Sezaki; M. Hashida T. Fujita; H. Furitsu; M. Nishikawa; Y. Takakura; H. Sezaki; M. Hashida Therapeutic effects of superoxide dismutase derivatives modified with mono- or polysaccharides on hepatic injury induced by ischemia/reperfusion Therapeutic effects of superoxide dismutase derivatives modified with mono- or polysaccharides on hepatic injury induced by ischemia/reperfusion Therapeutic effects of superoxide dismutase derivatives modified with mono- or polysaccharides on hepatic injury induced by ischemia/reperfusion Biochemical and Biophysical Research Communications, 189, 1, 191-196 Biochemical and Biophysical Research Communications, 189, 1, 191-196 Biochemical and Biophysical Research Communications, 189, 1, 191-196 1992/11/30 英語 公開
H. Imoto; Y. Sakamura; K. Ohkouchi; R. Atsumi; Y. Takakura; H. Sezaki; M. Hashida H. Imoto; Y. Sakamura; K. Ohkouchi; R. Atsumi; Y. Takakura; H. Sezaki; M. Hashida H. Imoto; Y. Sakamura; K. Ohkouchi; R. Atsumi; Y. Takakura; H. Sezaki; M. Hashida Disposition characteristics of macromolecules in the perfused tissue-isolated tumor preparation Disposition characteristics of macromolecules in the perfused tissue-isolated tumor preparation Disposition characteristics of macromolecules in the perfused tissue-isolated tumor preparation Cancer Research, 52, 16, 4396-4401 Cancer Research, 52, 16, 4396-4401 Cancer Research, 52, 16, 4396-4401 1992/08/15 英語 公開
M. Nishikawa; F. Yamashita; Y. Takakura; M. Hashida; H. Sezaki M. Nishikawa; F. Yamashita; Y. Takakura; M. Hashida; H. Sezaki M. Nishikawa; F. Yamashita; Y. Takakura; M. Hashida; H. Sezaki Demonstration of the receptor-mediated hepatic uptake of dextran in mice Demonstration of the receptor-mediated hepatic uptake of dextran in mice Demonstration of the receptor-mediated hepatic uptake of dextran in mice Journal of Pharmacy and Pharmacology, 44, 5, 396-401 Journal of Pharmacy and Pharmacology, 44, 5, 396-401 Journal of Pharmacy and Pharmacology, 44, 5, 396-401 1992/05 英語 公開
A. Noguchi; T. Takahashi; T. Yamaguchi; K. Kitamura; Y. Takakura; M. Hashida; H. Sezaki A. Noguchi; T. Takahashi; T. Yamaguchi; K. Kitamura; Y. Takakura; M. Hashida; H. Sezaki A. Noguchi; T. Takahashi; T. Yamaguchi; K. Kitamura; Y. Takakura; M. Hashida; H. Sezaki Preparation and properties of the immunoconjugate composed of anti-human colon cancer monoclonal antibody and mitomycin C-dextran conjugate Preparation and properties of the immunoconjugate composed of anti-human colon cancer monoclonal antibody and mitomycin C-dextran conjugate Preparation and properties of the immunoconjugate composed of anti-human colon cancer monoclonal antibody and mitomycin C-dextran conjugate Bioconjugate Chemistry, 3, 2, 132-137 Bioconjugate Chemistry, 3, 2, 132-137 Bioconjugate Chemistry, 3, 2, 132-137 1992/03 英語 公開
M. Masegi; N. Wakabayashi; K. Sagara; Y. Teramura; A. Yamamoto; Y. Takakura; M. Hashida; H. Sezaki M. Masegi; N. Wakabayashi; K. Sagara; Y. Teramura; A. Yamamoto; Y. Takakura; M. Hashida; H. Sezaki M. Masegi; N. Wakabayashi; K. Sagara; Y. Teramura; A. Yamamoto; Y. Takakura; M. Hashida; H. Sezaki Permeability of macromolecules in cultured endothelial and tumor cell layers on microporous membranes Permeability of macromolecules in cultured endothelial and tumor cell layers on microporous membranes Permeability of macromolecules in cultured endothelial and tumor cell layers on microporous membranes International Journal of Pharmaceutics, 78, 2-3, 103-113 International Journal of Pharmaceutics, 78, 2-3, 103-113 International Journal of Pharmaceutics, 78, 2-3, 103-113 1992/01/05 英語 公開
Y. Takakura; K.L. Audus; R.T. Borchardt Y. Takakura; K.L. Audus; R.T. Borchardt Y. Takakura; K.L. Audus; R.T. Borchardt Cultured brain microvessel endothelial cells as in vitro models of the blood-brain barrier. Cultured brain microvessel endothelial cells as in vitro models of the blood-brain barrier. Cultured brain microvessel endothelial cells as in vitro models of the blood-brain barrier. NIDA research monograph, 120, 138-152 NIDA research monograph, 120, 138-152 NIDA research monograph, 120, 138-152 1992 英語 公開
Y. Takakura; S.L. Kuentzel; T.J. Raub; A. Davies; S.A. Baldwin; R.T. Borchardt Y. Takakura; S.L. Kuentzel; T.J. Raub; A. Davies; S.A. Baldwin; R.T. Borchardt Y. Takakura; S.L. Kuentzel; T.J. Raub; A. Davies; S.A. Baldwin; R.T. Borchardt Hexose uptake in primary cultures of bovine brain microvessel endothetial cells. I. Basic characteristics and effects of d-glucose and insulin Hexose uptake in primary cultures of bovine brain microvessel endothetial cells. I. Basic characteristics and effects of d-glucose and insulin Hexose uptake in primary cultures of bovine brain microvessel endothetial cells. I. Basic characteristics and effects of d-glucose and insulin BBA - Biomembranes, 1070, 1, 1-10 BBA - Biomembranes, 1070, 1, 1-10 BBA - Biomembranes, 1070, 1, 1-10 1991/11/18 英語 公開
Y. Takakura; A.M. Trammel; S.L. Kuentzel; T.J. Raub; A. Davies; S.A. Baldwin; R.T. Borchardt Y. Takakura; A.M. Trammel; S.L. Kuentzel; T.J. Raub; A. Davies; S.A. Baldwin; R.T. Borchardt Y. Takakura; A.M. Trammel; S.L. Kuentzel; T.J. Raub; A. Davies; S.A. Baldwin; R.T. Borchardt Hexose uptake in primary cultures of bovine brain microvessel endothelial cells. II. Effects of conditioned media from astroglial and glioma cells Hexose uptake in primary cultures of bovine brain microvessel endothelial cells. II. Effects of conditioned media from astroglial and glioma cells Hexose uptake in primary cultures of bovine brain microvessel endothelial cells. II. Effects of conditioned media from astroglial and glioma cells BBA - Biomembranes, 1070, 1, 11-19 BBA - Biomembranes, 1070, 1, 11-19 BBA - Biomembranes, 1070, 1, 11-19 1991/11/18 英語 公開
T. Fujita; Y. Yasuda; Y. Takakura; M. Hashida; H. Sezaki T. Fujita; Y. Yasuda; Y. Takakura; M. Hashida; H. Sezaki T. Fujita; Y. Yasuda; Y. Takakura; M. Hashida; H. Sezaki Tissue distribution of <sup>111</sup>In-labeled uricase conjugated with charged dextrans and polyethylene glycol Tissue distribution of <sup>111</sup>In-labeled uricase conjugated with charged dextrans and polyethylene glycol Tissue distribution of <sup>111</sup>In-labeled uricase conjugated with charged dextrans and polyethylene glycol Journal of Pharmacobio-Dynamics, 14, 11, 623-629 Journal of Pharmacobio-Dynamics, 14, 11, 623-629 Journal of Pharmacobio-Dynamics, 14, 11, 623-629 1991/11 英語 公開
Y. Takakura; K.L. Audus; R.T. Borchardt Y. Takakura; K.L. Audus; R.T. Borchardt Y. Takakura; K.L. Audus; R.T. Borchardt Blood-brain barrier: transport studies in isolated brain capillaries and in cultured brain endothelial cells. Blood-brain barrier: transport studies in isolated brain capillaries and in cultured brain endothelial cells. Blood-brain barrier: transport studies in isolated brain capillaries and in cultured brain endothelial cells. Advances in pharmacology (San Diego, Calif.), 22, 137-165 Advances in pharmacology (San Diego, Calif.), 22, 137-165 Advances in pharmacology (San Diego, Calif.), 22, 137-165 1991 英語 公開
K. Nishida; K. Mihara; T. Takino; S. Nakane; Y. Takakura; M. Hashida; H. Sezaki K. Nishida; K. Mihara; T. Takino; S. Nakane; Y. Takakura; M. Hashida; H. Sezaki K. Nishida; K. Mihara; T. Takino; S. Nakane; Y. Takakura; M. Hashida; H. Sezaki Hepatic disposition characteristics of electrically charged macromolecules in rat in vivo and in the perfused liver Hepatic disposition characteristics of electrically charged macromolecules in rat in vivo and in the perfused liver Hepatic disposition characteristics of electrically charged macromolecules in rat in vivo and in the perfused liver Pharmaceutical Research, 8, 4, 437-444 Pharmaceutical Research, 8, 4, 437-444 Pharmaceutical Research, 8, 4, 437-444 1991 英語 公開
K. Nishida; Y. Eguchi; T. Takino; Y. Takakura; M. Hashida; H. Sezaki K. Nishida; Y. Eguchi; T. Takino; Y. Takakura; M. Hashida; H. Sezaki K. Nishida; Y. Eguchi; T. Takino; Y. Takakura; M. Hashida; H. Sezaki Hepatic disposition characteristics of <sup>111</sup>In-labeled lactosaminated bovine serum albumin in rats Hepatic disposition characteristics of <sup>111</sup>In-labeled lactosaminated bovine serum albumin in rats Hepatic disposition characteristics of <sup>111</sup>In-labeled lactosaminated bovine serum albumin in rats Pharmaceutical Research, 8, 10, 1253-1257 Pharmaceutical Research, 8, 10, 1253-1257 Pharmaceutical Research, 8, 10, 1253-1257 1991 英語 公開
T. Fujita; Y. Takakura; M. Hashida; H. Sezaki T. Fujita; Y. Takakura; M. Hashida; H. Sezaki T. Fujita; Y. Takakura; M. Hashida; H. Sezaki Control of in vivo fate of protein drugs using chemical modification with sugars Control of in vivo fate of protein drugs using chemical modification with sugars Control of in vivo fate of protein drugs using chemical modification with sugars Journal of Pharmacobio-Dynamics, 14, 2, s-29 Journal of Pharmacobio-Dynamics, 14, 2, s-29 Journal of Pharmacobio-Dynamics, 14, 2, s-29 1991 英語 公開
Y. Takakura; T. Fujita; M. Hashida; H. Sezaki Y. Takakura; T. Fujita; M. Hashida; H. Sezaki Y. Takakura; T. Fujita; M. Hashida; H. Sezaki Disposition characteristics of macromolecules in tumor-bearing mice Disposition characteristics of macromolecules in tumor-bearing mice Disposition characteristics of macromolecules in tumor-bearing mice Pharmaceutical Research, 7, 4, 339-346 Pharmaceutical Research, 7, 4, 339-346 Pharmaceutical Research, 7, 4, 339-346 1990/04 英語 公開
M. Hashida; R. Atsumi; K. Nishida; S. Nakane; Y. Takakura; H. Sezaki M. Hashida; R. Atsumi; K. Nishida; S. Nakane; Y. Takakura; H. Sezaki M. Hashida; R. Atsumi; K. Nishida; S. Nakane; Y. Takakura; H. Sezaki Biliary excretion of mitomycin C dextran conjugates in relation to physico-chemical characteristics of carrier dextran Biliary excretion of mitomycin C dextran conjugates in relation to physico-chemical characteristics of carrier dextran Biliary excretion of mitomycin C dextran conjugates in relation to physico-chemical characteristics of carrier dextran Journal of Pharmacobio-Dynamics, 13, 7, 441-447 Journal of Pharmacobio-Dynamics, 13, 7, 441-447 Journal of Pharmacobio-Dynamics, 13, 7, 441-447 1990 英語 公開
Y. Yasuda; T. Fujita; Y. Takakura; M. Hashida; H. Sezaki Y. Yasuda; T. Fujita; Y. Takakura; M. Hashida; H. Sezaki Y. Yasuda; T. Fujita; Y. Takakura; M. Hashida; H. Sezaki Biochemical and biopharmaceutical properties of macromolecular conjugates of uricase with dextran and polyethylene glycol Biochemical and biopharmaceutical properties of macromolecular conjugates of uricase with dextran and polyethylene glycol Biochemical and biopharmaceutical properties of macromolecular conjugates of uricase with dextran and polyethylene glycol Chemical and Pharmaceutical Bulletin, 38, 7, 2053-2056 Chemical and Pharmaceutical Bulletin, 38, 7, 2053-2056 Chemical and Pharmaceutical Bulletin, 38, 7, 2053-2056 1990 英語 公開
K. Ohkouchi; H. Imoto; Y. Takakura; M. Hashida; H. Sezaki K. Ohkouchi; H. Imoto; Y. Takakura; M. Hashida; H. Sezaki K. Ohkouchi; H. Imoto; Y. Takakura; M. Hashida; H. Sezaki Disposition of anticancer drugs after bolus arterial administration in a tissue-isolated tumor perfusion system Disposition of anticancer drugs after bolus arterial administration in a tissue-isolated tumor perfusion system Disposition of anticancer drugs after bolus arterial administration in a tissue-isolated tumor perfusion system Cancer Research, 50, 5, 1640-1644 Cancer Research, 50, 5, 1640-1644 Cancer Research, 50, 5, 1640-1644 1990 英語 公開
TAKAKURA, Y; MATSUMOTO, S; HASHIDA, M; SEZAKI, H TAKAKURA, Y; MATSUMOTO, S; HASHIDA, M; SEZAKI, H TAKAKURA, Y; MATSUMOTO, S; HASHIDA, M; SEZAKI, H PHYSICOCHEMICAL PROPERTIES AND ANTITUMOR ACTIVITIES OF POLYMERIC PRODRUGS OF MITOMYCIN-C WITH DIFFERENT REGENERATION RATES PHYSICOCHEMICAL PROPERTIES AND ANTITUMOR ACTIVITIES OF POLYMERIC PRODRUGS OF MITOMYCIN-C WITH DIFFERENT REGENERATION RATES PHYSICOCHEMICAL PROPERTIES AND ANTITUMOR ACTIVITIES OF POLYMERIC PRODRUGS OF MITOMYCIN-C WITH DIFFERENT REGENERATION RATES JOURNAL OF CONTROLLED RELEASE, 10, 1, 97-105 JOURNAL OF CONTROLLED RELEASE, 10, 1, 97-105 JOURNAL OF CONTROLLED RELEASE, 10, 1, 97-105 1989/10 英語 公開
Y. Takakura; T. Fujita; M. Hashida; H. Maeda; H. Sezaki Y. Takakura; T. Fujita; M. Hashida; H. Maeda; H. Sezaki Y. Takakura; T. Fujita; M. Hashida; H. Maeda; H. Sezaki Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran II: Biopharmaceutical and pharmacological properties Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran II: Biopharmaceutical and pharmacological properties Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran II: Biopharmaceutical and pharmacological properties Journal of Pharmaceutical Sciences, 78, 3, 219-222 Journal of Pharmaceutical Sciences, 78, 3, 219-222 Journal of Pharmaceutical Sciences, 78, 3, 219-222 1989/03 英語 公開
Y. Takakura; Y. Kaneko; T. Fujita; M. Hashida; H. Maeda; H. Sezaki Y. Takakura; Y. Kaneko; T. Fujita; M. Hashida; H. Maeda; H. Sezaki Y. Takakura; Y. Kaneko; T. Fujita; M. Hashida; H. Maeda; H. Sezaki Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran I: Synthesis and characterization Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran I: Synthesis and characterization Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran I: Synthesis and characterization Journal of Pharmaceutical Sciences, 78, 2, 117-121 Journal of Pharmaceutical Sciences, 78, 2, 117-121 Journal of Pharmaceutical Sciences, 78, 2, 117-121 1989/02 英語 公開
H. Sezaki; Y. Takakura; M. Hashida H. Sezaki; Y. Takakura; M. Hashida H. Sezaki; Y. Takakura; M. Hashida Soluble macromolecular carriers for the delivery of antitumour drugs Soluble macromolecular carriers for the delivery of antitumour drugs Soluble macromolecular carriers for the delivery of antitumour drugs Advanced Drug Delivery Reviews, 3, 2, 247-266 Advanced Drug Delivery Reviews, 3, 2, 247-266 Advanced Drug Delivery Reviews, 3, 2, 247-266 1989 英語 公開
K. Sato; K. Itakura; K. Nishida; Y. Takakura; M. Hashida; H. Sezaki K. Sato; K. Itakura; K. Nishida; Y. Takakura; M. Hashida; H. Sezaki K. Sato; K. Itakura; K. Nishida; Y. Takakura; M. Hashida; H. Sezaki Disposition of a polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate, in the perfused rat liver Disposition of a polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate, in the perfused rat liver Disposition of a polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate, in the perfused rat liver Journal of Pharmaceutical Sciences, 78, 1, 11-16 Journal of Pharmaceutical Sciences, 78, 1, 11-16 Journal of Pharmaceutical Sciences, 78, 1, 11-16 1989 英語 公開
Y. Takakura; M. Hashida; H. Sezaki; K. Honda; A. Noguchi; T. Takahashi Y. Takakura; M. Hashida; H. Sezaki; K. Honda; A. Noguchi; T. Takahashi Y. Takakura; M. Hashida; H. Sezaki; K. Honda; A. Noguchi; T. Takahashi Design and evaluation of monoclonal antibody-antitumor agent conjugate Design and evaluation of monoclonal antibody-antitumor agent conjugate Design and evaluation of monoclonal antibody-antitumor agent conjugate Journal of Pharmacobio-Dynamics, 12, 2, s-32 Journal of Pharmacobio-Dynamics, 12, 2, s-32 Journal of Pharmacobio-Dynamics, 12, 2, s-32 1989 英語 公開
M. Hashida; K. Sato; Y. Takakura; H. Sezaki M. Hashida; K. Sato; Y. Takakura; H. Sezaki M. Hashida; K. Sato; Y. Takakura; H. Sezaki Characterization of a lipophilic prodrug of 5-fluorouracil with a cholesterol promoiety and its application to liposomes Characterization of a lipophilic prodrug of 5-fluorouracil with a cholesterol promoiety and its application to liposomes Characterization of a lipophilic prodrug of 5-fluorouracil with a cholesterol promoiety and its application to liposomes Chemical and Pharmaceutical Bulletin, 36, 8, 3186-3189 Chemical and Pharmaceutical Bulletin, 36, 8, 3186-3189 Chemical and Pharmaceutical Bulletin, 36, 8, 3186-3189 1988 英語 公開
H. Sezaki; Y. Takakura; M. Hashida H. Sezaki; Y. Takakura; M. Hashida H. Sezaki; Y. Takakura; M. Hashida Control of biopharmaceutical properties by dextran conjugates Control of biopharmaceutical properties by dextran conjugates Control of biopharmaceutical properties by dextran conjugates Journal of Bioactive and Compatible Polymers, 3, 1, 81-85 Journal of Bioactive and Compatible Polymers, 3, 1, 81-85 Journal of Bioactive and Compatible Polymers, 3, 1, 81-85 1988 英語 公開
S. Nakane; S. Matsumoto; Y. Takakura; M. Hashida; H. Sezaki S. Nakane; S. Matsumoto; Y. Takakura; M. Hashida; H. Sezaki S. Nakane; S. Matsumoto; Y. Takakura; M. Hashida; H. Sezaki The accumulation mechanism of cationic mitomycin C-dextran conjugates in the liver: In-vivo cellular localization and in-vitro interaction with hepatocytes The accumulation mechanism of cationic mitomycin C-dextran conjugates in the liver: In-vivo cellular localization and in-vitro interaction with hepatocytes The accumulation mechanism of cationic mitomycin C-dextran conjugates in the liver: In-vivo cellular localization and in-vitro interaction with hepatocytes Journal of Pharmacy and Pharmacology, 40, 1, 1-6 Journal of Pharmacy and Pharmacology, 40, 1, 1-6 Journal of Pharmacy and Pharmacology, 40, 1, 1-6 1988 英語 公開
A. Noguchi; T. Takahashi; T. Yamaguchi; K. Kitamura; T. Yokota; Y. Takakura; M. Hashida; H. Sezaki A. Noguchi; T. Takahashi; T. Yamaguchi; K. Kitamura; T. Yokota; Y. Takakura; M. Hashida; H. Sezaki A. Noguchi; T. Takahashi; T. Yamaguchi; K. Kitamura; T. Yokota; Y. Takakura; M. Hashida; H. Sezaki Development of monoclonal antibody-drug conjugate A7-MMC utilizing dextran as intermediate carrier Development of monoclonal antibody-drug conjugate A7-MMC utilizing dextran as intermediate carrier Development of monoclonal antibody-drug conjugate A7-MMC utilizing dextran as intermediate carrier International Journal of Immunopharmacology, 10, SUPPL. 1, 33- International Journal of Immunopharmacology, 10, SUPPL. 1, 33- International Journal of Immunopharmacology, 10, SUPPL. 1, 33- 1988 英語 公開
Y. Takakura; A. Takagi; M. Hashida; H. Sezaki Y. Takakura; A. Takagi; M. Hashida; H. Sezaki Y. Takakura; A. Takagi; M. Hashida; H. Sezaki Disposition and tumor localization of mitomycin C - Dextran conjugates in mice Disposition and tumor localization of mitomycin C - Dextran conjugates in mice Disposition and tumor localization of mitomycin C - Dextran conjugates in mice Pharmaceutical Research, 4, 4, 293-300 Pharmaceutical Research, 4, 4, 293-300 Pharmaceutical Research, 4, 4, 293-300 1987/08 英語 公開
Y. Takakura; M. Kitajima; S. Matsumoto; M. Hashida; H. Sezaki Y. Takakura; M. Kitajima; S. Matsumoto; M. Hashida; H. Sezaki Y. Takakura; M. Kitajima; S. Matsumoto; M. Hashida; H. Sezaki Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with anionic charge. I. Physicochemical characteristics and in vivo and in vitro antitumor activities Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with anionic charge. I. Physicochemical characteristics and in vivo and in vitro antitumor activities Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with anionic charge. I. Physicochemical characteristics and in vivo and in vitro antitumor activities International Journal of Pharmaceutics, 37, 1/2, 135-143 International Journal of Pharmaceutics, 37, 1/2, 135-143 International Journal of Pharmaceutics, 37, 1/2, 135-143 1987 英語 公開
Y. Takakura; R. Atsumi; M. Hashida; H. Sezaki Y. Takakura; R. Atsumi; M. Hashida; H. Sezaki Y. Takakura; R. Atsumi; M. Hashida; H. Sezaki Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with anionic charge. II. Disposition and pharmacokinetics following intravenous and intramuscular administration Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with anionic charge. II. Disposition and pharmacokinetics following intravenous and intramuscular administration Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with anionic charge. II. Disposition and pharmacokinetics following intravenous and intramuscular administration International Journal of Pharmaceutics, 37, 1/2, 145-154 International Journal of Pharmaceutics, 37, 1/2, 145-154 International Journal of Pharmaceutics, 37, 1/2, 145-154 1987 英語 公開
S. Matsumoto; T. Shigeoka; Y. Takakura; M. Hashida; H. Sezaki S. Matsumoto; T. Shigeoka; Y. Takakura; M. Hashida; H. Sezaki S. Matsumoto; T. Shigeoka; Y. Takakura; M. Hashida; H. Sezaki Cellular interaction and in vitro antitumor effect of various mitomycin C prodrugs in mitomycin C-resistant L1210 leukemia cell lines Cellular interaction and in vitro antitumor effect of various mitomycin C prodrugs in mitomycin C-resistant L1210 leukemia cell lines Cellular interaction and in vitro antitumor effect of various mitomycin C prodrugs in mitomycin C-resistant L1210 leukemia cell lines Chemical and Pharmaceutical Bulletin, 35, 9, 3792-3799 Chemical and Pharmaceutical Bulletin, 35, 9, 3792-3799 Chemical and Pharmaceutical Bulletin, 35, 9, 3792-3799 1987 英語 公開
R. Atsumi; K. Endo; T. Kakutani; Y. Takakura; M. Hashida; H. Sezaki R. Atsumi; K. Endo; T. Kakutani; Y. Takakura; M. Hashida; H. Sezaki R. Atsumi; K. Endo; T. Kakutani; Y. Takakura; M. Hashida; H. Sezaki Disposition characteristics of mitomycin C-dextran conjugate in normal and tumor-bearing muscles of rabbits Disposition characteristics of mitomycin C-dextran conjugate in normal and tumor-bearing muscles of rabbits Disposition characteristics of mitomycin C-dextran conjugate in normal and tumor-bearing muscles of rabbits Cancer Research, 47, 21, 5546-5551 Cancer Research, 47, 21, 5546-5551 Cancer Research, 47, 21, 5546-5551 1987 英語 公開
S. Matsumoto; A. Yamamoto; Y. Takakura; M. Hashida; N. Tanigawa; H. Sezaki S. Matsumoto; A. Yamamoto; Y. Takakura; M. Hashida; N. Tanigawa; H. Sezaki S. Matsumoto; A. Yamamoto; Y. Takakura; M. Hashida; N. Tanigawa; H. Sezaki Cellular interaction and in vitro antitumor activity of mitomycin C-dextran conjugate Cellular interaction and in vitro antitumor activity of mitomycin C-dextran conjugate Cellular interaction and in vitro antitumor activity of mitomycin C-dextran conjugate Cancer Research, 46, 9, 4463-4468 Cancer Research, 46, 9, 4463-4468 Cancer Research, 46, 9, 4463-4468 1986 英語 公開
Y. Takakura; K. Mori; M. Hashida; H. Sezaki Y. Takakura; K. Mori; M. Hashida; H. Sezaki Y. Takakura; K. Mori; M. Hashida; H. Sezaki Absorption characteristics of macromolecular prodrugs of mitomycin C following intramuscular administration Absorption characteristics of macromolecular prodrugs of mitomycin C following intramuscular administration Absorption characteristics of macromolecular prodrugs of mitomycin C following intramuscular administration Chemical and Pharmaceutical Bulletin, 34, 4, 1775-1783 Chemical and Pharmaceutical Bulletin, 34, 4, 1775-1783 Chemical and Pharmaceutical Bulletin, 34, 4, 1775-1783 1986 英語 公開
S. Matsumoto; Y. Arase; Y. Takakura; M. Hashida; H. Sezaki S. Matsumoto; Y. Arase; Y. Takakura; M. Hashida; H. Sezaki S. Matsumoto; Y. Arase; Y. Takakura; M. Hashida; H. Sezaki Plasma disposition and in vivo and in vitro antitumor activities of mitomycin C-dextran conjugate in relation to the mode of action Plasma disposition and in vivo and in vitro antitumor activities of mitomycin C-dextran conjugate in relation to the mode of action Plasma disposition and in vivo and in vitro antitumor activities of mitomycin C-dextran conjugate in relation to the mode of action Chemical and Pharmaceutical Bulletin, 33, 7, 2941-2947 Chemical and Pharmaceutical Bulletin, 33, 7, 2941-2947 Chemical and Pharmaceutical Bulletin, 33, 7, 2941-2947 1985 英語 公開
Y. Takakura; A. Kato; M. Hashida; K. Honda; A. Arimoto; K. Satomura; H. Sezaki Y. Takakura; A. Kato; M. Hashida; K. Honda; A. Arimoto; K. Satomura; H. Sezaki Y. Takakura; A. Kato; M. Hashida; K. Honda; A. Arimoto; K. Satomura; H. Sezaki Urinary excretion characteristics of a polymeric pro-drug of mitomycin C, mytomicin C-dextran conjugate Urinary excretion characteristics of a polymeric pro-drug of mitomycin C, mytomicin C-dextran conjugate Urinary excretion characteristics of a polymeric pro-drug of mitomycin C, mytomicin C-dextran conjugate Journal of Pharmacobio-Dynamics, 8, 5, 357-364 Journal of Pharmacobio-Dynamics, 8, 5, 357-364 Journal of Pharmacobio-Dynamics, 8, 5, 357-364 1985 英語 公開
T. Ohsawa; Y. Matsukawa; Y. Takakura; M. Hashida; H. Sezaki T. Ohsawa; Y. Matsukawa; Y. Takakura; M. Hashida; H. Sezaki T. Ohsawa; Y. Matsukawa; Y. Takakura; M. Hashida; H. Sezaki Fate of lipid and encapsulated drug after intramuscular administration of liposomes prepared by the freeze-thawing method in rats Fate of lipid and encapsulated drug after intramuscular administration of liposomes prepared by the freeze-thawing method in rats Fate of lipid and encapsulated drug after intramuscular administration of liposomes prepared by the freeze-thawing method in rats Chemical and Pharmaceutical Bulletin, 33, 11, 5013-5022 Chemical and Pharmaceutical Bulletin, 33, 11, 5013-5022 Chemical and Pharmaceutical Bulletin, 33, 11, 5013-5022 1985 英語 公開
S. Matsumoto; Y. Takakura; M. Hashida; H. Sezaki S. Matsumoto; Y. Takakura; M. Hashida; H. Sezaki S. Matsumoto; Y. Takakura; M. Hashida; H. Sezaki Cellular interaction and antitumor activity of mitomycin C prodrugs Cellular interaction and antitumor activity of mitomycin C prodrugs Cellular interaction and antitumor activity of mitomycin C prodrugs Journal of Pharmacobio-Dynamics, 8, 6, S140 Journal of Pharmacobio-Dynamics, 8, 6, S140 Journal of Pharmacobio-Dynamics, 8, 6, S140 1985 英語 公開
Y. Takakura; S. Matsumoto; M. Hashida; H. Sezaki Y. Takakura; S. Matsumoto; M. Hashida; H. Sezaki Y. Takakura; S. Matsumoto; M. Hashida; H. Sezaki Enhanced lymphatic delivery of mitomycin C conjugated with dextran Enhanced lymphatic delivery of mitomycin C conjugated with dextran Enhanced lymphatic delivery of mitomycin C conjugated with dextran Cancer Research, 44, 6, 2505-2510 Cancer Research, 44, 6, 2505-2510 Cancer Research, 44, 6, 2505-2510 1984 英語 公開
C.F. Roos; M. Satoshi; T. Yoshinobu; H. Mitsuru; S. Hitoshi C.F. Roos; M. Satoshi; T. Yoshinobu; H. Mitsuru; S. Hitoshi C.F. Roos; M. Satoshi; T. Yoshinobu; H. Mitsuru; S. Hitoshi Physicochemical and antitumor characteristics of some polyamino acid prodrugs of mitomycin C Physicochemical and antitumor characteristics of some polyamino acid prodrugs of mitomycin C Physicochemical and antitumor characteristics of some polyamino acid prodrugs of mitomycin C International Journal of Pharmaceutics, 22, 1, 75-87 International Journal of Pharmaceutics, 22, 1, 75-87 International Journal of Pharmaceutics, 22, 1, 75-87 1984 英語 公開
M. Hashida; A. Kato; Y. Takakura; H. Sezaki M. Hashida; A. Kato; Y. Takakura; H. Sezaki M. Hashida; A. Kato; Y. Takakura; H. Sezaki Disposition and pharmacokinetics of a polymeric prodrug of mitomycin c, mitomycin c-dextran conjugate, in the rat Disposition and pharmacokinetics of a polymeric prodrug of mitomycin c, mitomycin c-dextran conjugate, in the rat Disposition and pharmacokinetics of a polymeric prodrug of mitomycin c, mitomycin c-dextran conjugate, in the rat Drug Metabolism and Disposition, 12, 4, 492-499 Drug Metabolism and Disposition, 12, 4, 492-499 Drug Metabolism and Disposition, 12, 4, 492-499 1984 英語 公開
H. Sasaki; Y. Takakura; M. Hashida; T. Kimura; H. Sezaki H. Sasaki; Y. Takakura; M. Hashida; T. Kimura; H. Sezaki H. Sasaki; Y. Takakura; M. Hashida; T. Kimura; H. Sezaki Antitumor activity of lipophilic prodrugs of mitomycin C entrapped in liposome or O/W emulsion Antitumor activity of lipophilic prodrugs of mitomycin C entrapped in liposome or O/W emulsion Antitumor activity of lipophilic prodrugs of mitomycin C entrapped in liposome or O/W emulsion Journal of Pharmacobio-Dynamics, 7, 2, 120-130 Journal of Pharmacobio-Dynamics, 7, 2, 120-130 Journal of Pharmacobio-Dynamics, 7, 2, 120-130 1984 英語 公開
M. Hashida; Y. Takakura; S. Matsumoto; H. Sasaki; A. Kato; T. Kojima; S. Muranishi; H. Sezaki M. Hashida; Y. Takakura; S. Matsumoto; H. Sasaki; A. Kato; T. Kojima; S. Muranishi; H. Sezaki M. Hashida; Y. Takakura; S. Matsumoto; H. Sasaki; A. Kato; T. Kojima; S. Muranishi; H. Sezaki Regeneration characteristics of mitomycin C-dextran conjugate in relation to its activity Regeneration characteristics of mitomycin C-dextran conjugate in relation to its activity Regeneration characteristics of mitomycin C-dextran conjugate in relation to its activity Chemical and Pharmaceutical Bulletin, 31, 6, 2055-2063 Chemical and Pharmaceutical Bulletin, 31, 6, 2055-2063 Chemical and Pharmaceutical Bulletin, 31, 6, 2055-2063 1983 英語 公開
A. Kato; Y. Takakura; M. Hashida; T. Kimura; H. Sezaki A. Kato; Y. Takakura; M. Hashida; T. Kimura; H. Sezaki A. Kato; Y. Takakura; M. Hashida; T. Kimura; H. Sezaki Physico-chemical and antitumor characteristics of high molecular weight prodrugs of mitomycin C Physico-chemical and antitumor characteristics of high molecular weight prodrugs of mitomycin C Physico-chemical and antitumor characteristics of high molecular weight prodrugs of mitomycin C Chemical and Pharmaceutical Bulletin, 30, 8, 2951-2957 Chemical and Pharmaceutical Bulletin, 30, 8, 2951-2957 Chemical and Pharmaceutical Bulletin, 30, 8, 2951-2957 1982 英語 公開

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著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
M. Hashida; M. Nishikawa; F. Yamashita; Y. Takakura M. Hashida; M. Nishikawa; F. Yamashita; Y. Takakura M. Hashida; M. Nishikawa; F. Yamashita; Y. Takakura Cell-specific targeting of drugs and genes with glycosylated liposomes: Comparison with glycosylated poly(amino acids) Cell-specific targeting of drugs and genes with glycosylated liposomes: Comparison with glycosylated poly(amino acids) Cell-specific targeting of drugs and genes with glycosylated liposomes: Comparison with glycosylated poly(amino acids) ACS Symposium Series, 752, 201-211 ACS Symposium Series, 752, 201-211 ACS Symposium Series, 752, 201-211 2000 英語 公開
N. Yoshimura; H. Yura; T. Hamashima; T. Oka; Y. Takakura; M. Hadhida N. Yoshimura; H. Yura; T. Hamashima; T. Oka; Y. Takakura; M. Hadhida N. Yoshimura; H. Yura; T. Hamashima; T. Oka; Y. Takakura; M. Hadhida Development of a macromolecular prodrug of FK 506: III: In vivo disposition of FK 506-dextran conjugate Development of a macromolecular prodrug of FK 506: III: In vivo disposition of FK 506-dextran conjugate Development of a macromolecular prodrug of FK 506: III: In vivo disposition of FK 506-dextran conjugate Transplantation Proceedings, 30, 4, 1029-1030 Transplantation Proceedings, 30, 4, 1029-1030 Transplantation Proceedings, 30, 4, 1029-1030 1998 英語 公開
H. Yura; N. Yoshimura; T. Hamashima; T. Oka; Y. Takakura; M. Hashida H. Yura; N. Yoshimura; T. Hamashima; T. Oka; Y. Takakura; M. Hashida H. Yura; N. Yoshimura; T. Hamashima; T. Oka; Y. Takakura; M. Hashida Development of a macromolecular prodrug of FK 506: II: In vitro study for FK 506-dextran conjugate Development of a macromolecular prodrug of FK 506: II: In vitro study for FK 506-dextran conjugate Development of a macromolecular prodrug of FK 506: II: In vitro study for FK 506-dextran conjugate Transplantation Proceedings, 30, 4, 1031-1032 Transplantation Proceedings, 30, 4, 1031-1032 Transplantation Proceedings, 30, 4, 1031-1032 1998 英語 公開
H. Yura; N. Yoshimura; T. Hamashima; T. Oka; Y. Takakura; M. Hashida H. Yura; N. Yoshimura; T. Hamashima; T. Oka; Y. Takakura; M. Hashida H. Yura; N. Yoshimura; T. Hamashima; T. Oka; Y. Takakura; M. Hashida Development of a macromolecular prodrug of FK506: I. Synthesis of FK506-dextran conjugate Development of a macromolecular prodrug of FK506: I. Synthesis of FK506-dextran conjugate Development of a macromolecular prodrug of FK506: I. Synthesis of FK506-dextran conjugate Transplantation Proceedings, 30, 7, 3598-3599 Transplantation Proceedings, 30, 7, 3598-3599 Transplantation Proceedings, 30, 7, 3598-3599 1998 英語 公開
M. Nishikawa; P. Opanasopit; K. Shiraishi; Y. Takakura; M. Hashida M. Nishikawa; P. Opanasopit; K. Shiraishi; Y. Takakura; M. Hashida M. Nishikawa; P. Opanasopit; K. Shiraishi; Y. Takakura; M. Hashida Pharmacokinetic analysis of mannose receptor-mediated hepatic targeting of proteins: Capacity-limited hepatic uptake and saturable binding in plasma Pharmacokinetic analysis of mannose receptor-mediated hepatic targeting of proteins: Capacity-limited hepatic uptake and saturable binding in plasma Pharmacokinetic analysis of mannose receptor-mediated hepatic targeting of proteins: Capacity-limited hepatic uptake and saturable binding in plasma Proceedings of the Controlled Release Society, 25, 506-507 Proceedings of the Controlled Release Society, 25, 506-507 Proceedings of the Controlled Release Society, 25, 506-507 1998 英語 公開
K. Kawabata; Y. Watanabe; Y. Takakura; M. Hashida K. Kawabata; Y. Watanabe; Y. Takakura; M. Hashida K. Kawabata; Y. Watanabe; Y. Takakura; M. Hashida Interferon gene transfer into intestinal epithelial cells Interferon gene transfer into intestinal epithelial cells Interferon gene transfer into intestinal epithelial cells Proceedings of the Controlled Release Society, 23, 891-892 Proceedings of the Controlled Release Society, 23, 891-892 Proceedings of the Controlled Release Society, 23, 891-892 1996 英語 公開
K. Ogawara; M. Nishikawa; Y. Takakura; M. Hashida K. Ogawara; M. Nishikawa; Y. Takakura; M. Hashida K. Ogawara; M. Nishikawa; Y. Takakura; M. Hashida Hepatic disposition characteristics of glycosylated bovine serum albumin in rats Hepatic disposition characteristics of glycosylated bovine serum albumin in rats Hepatic disposition characteristics of glycosylated bovine serum albumin in rats Proceedings of the Controlled Release Society, 23, 665-666 Proceedings of the Controlled Release Society, 23, 665-666 Proceedings of the Controlled Release Society, 23, 665-666 1996 英語 公開
T. Takagi; T. Kanamaru; Y. Takakura; M. Hashida T. Takagi; T. Kanamaru; Y. Takakura; M. Hashida T. Takagi; T. Kanamaru; Y. Takakura; M. Hashida Biological activity and intracellular pharmacokinetics of antisense oligonucleotides: Effect of cationic liposomes Biological activity and intracellular pharmacokinetics of antisense oligonucleotides: Effect of cationic liposomes Biological activity and intracellular pharmacokinetics of antisense oligonucleotides: Effect of cationic liposomes Proceedings of the Controlled Release Society, 23, 905-906 Proceedings of the Controlled Release Society, 23, 905-906 Proceedings of the Controlled Release Society, 23, 905-906 1996 英語 公開
H. Masuda; Y. Takakura; M. Hashida H. Masuda; Y. Takakura; M. Hashida H. Masuda; Y. Takakura; M. Hashida Pharmacokinetics and hepatic uptake mechanism of recombinant rat decorin after intravenous injection in mice Pharmacokinetics and hepatic uptake mechanism of recombinant rat decorin after intravenous injection in mice Pharmacokinetics and hepatic uptake mechanism of recombinant rat decorin after intravenous injection in mice Proceedings of the Controlled Release Society, 23, 669-670 Proceedings of the Controlled Release Society, 23, 669-670 Proceedings of the Controlled Release Society, 23, 669-670 1996 英語 公開
H. Bando; M. Sahashi; F. Yamashita; Y. Takakura; M. Hashida H. Bando; M. Sahashi; F. Yamashita; Y. Takakura; M. Hashida H. Bando; M. Sahashi; F. Yamashita; Y. Takakura; M. Hashida Analysis of in vivo skin penetration enhancement by prodrug-enhancer combination based on a diffusion/bioconversion model Analysis of in vivo skin penetration enhancement by prodrug-enhancer combination based on a diffusion/bioconversion model Analysis of in vivo skin penetration enhancement by prodrug-enhancer combination based on a diffusion/bioconversion model Proceedings of the Controlled Release Society, 23, 277-278 Proceedings of the Controlled Release Society, 23, 277-278 Proceedings of the Controlled Release Society, 23, 277-278 1996 英語 公開
S. Takemura; M. Nishikawa; Y. Takakura; M. Hashida S. Takemura; M. Nishikawa; Y. Takakura; M. Hashida S. Takemura; M. Nishikawa; Y. Takakura; M. Hashida Pharmacokinetic analysis of hepatocyte-specific targeting of plasmid DNA using galactosylated poly-L-lysine Pharmacokinetic analysis of hepatocyte-specific targeting of plasmid DNA using galactosylated poly-L-lysine Pharmacokinetic analysis of hepatocyte-specific targeting of plasmid DNA using galactosylated poly-L-lysine Proceedings of the Controlled Release Society, 23, 901-902 Proceedings of the Controlled Release Society, 23, 901-902 Proceedings of the Controlled Release Society, 23, 901-902 1996 英語 公開
Y. Oka; Y. Takakura; M. Hashida Y. Oka; Y. Takakura; M. Hashida Y. Oka; Y. Takakura; M. Hashida Renal disposition characteristics of unmodified and phosphorothioated antisense oligonucleotides in situ and in vitro Renal disposition characteristics of unmodified and phosphorothioated antisense oligonucleotides in situ and in vitro Renal disposition characteristics of unmodified and phosphorothioated antisense oligonucleotides in situ and in vitro Proceedings of the Controlled Release Society, 23, 907-908 Proceedings of the Controlled Release Society, 23, 907-908 Proceedings of the Controlled Release Society, 23, 907-908 1996 英語 公開
T. Nomura; Y. Takakura; M. Hashida T. Nomura; Y. Takakura; M. Hashida T. Nomura; Y. Takakura; M. Hashida In vivo gene expression following direct injection of naked plasmid DNA into tumor In vivo gene expression following direct injection of naked plasmid DNA into tumor In vivo gene expression following direct injection of naked plasmid DNA into tumor Proceedings of the Controlled Release Society, 23, 909-910 Proceedings of the Controlled Release Society, 23, 909-910 Proceedings of the Controlled Release Society, 23, 909-910 1996 英語 公開
M. Nishikawa; Y. Takakura; M. Hashida M. Nishikawa; Y. Takakura; M. Hashida M. Nishikawa; Y. Takakura; M. Hashida Pharmacokinetic evaluation of the in vivo disposition characteristics of protein drugs radiolabeled by different methods Pharmacokinetic evaluation of the in vivo disposition characteristics of protein drugs radiolabeled by different methods Pharmacokinetic evaluation of the in vivo disposition characteristics of protein drugs radiolabeled by different methods Proceedings of the Controlled Release Society, 23, 875-876 Proceedings of the Controlled Release Society, 23, 875-876 Proceedings of the Controlled Release Society, 23, 875-876 1996 英語 公開
Y. Yabe; Y. Koyama; M. Nishikawa; Y. Takakura; M. Hashida Y. Yabe; Y. Koyama; M. Nishikawa; Y. Takakura; M. Hashida Y. Yabe; Y. Koyama; M. Nishikawa; Y. Takakura; M. Hashida Control of disposition characteristics of catalase by chemical modification Control of disposition characteristics of catalase by chemical modification Control of disposition characteristics of catalase by chemical modification Proceedings of the Controlled Release Society, 23, 649-650 Proceedings of the Controlled Release Society, 23, 649-650 Proceedings of the Controlled Release Society, 23, 649-650 1996 英語 公開
R.I. Mahato; Y. Takakura; M. Hashida R.I. Mahato; Y. Takakura; M. Hashida R.I. Mahato; Y. Takakura; M. Hashida Disposition and gene expression of plasmid DNA complexed with cationic carriers Disposition and gene expression of plasmid DNA complexed with cationic carriers Disposition and gene expression of plasmid DNA complexed with cationic carriers Proceedings of the Controlled Release Society, 23, 265-266 Proceedings of the Controlled Release Society, 23, 265-266 Proceedings of the Controlled Release Society, 23, 265-266 1996 英語 公開
Y. Takakura; T. Takagi; S. Masuda; M. Hashida Y. Takakura; T. Takagi; S. Masuda; M. Hashida Y. Takakura; T. Takagi; S. Masuda; M. Hashida Targeted delivery of superoxide dismutase to macrophages by direct cationization Targeted delivery of superoxide dismutase to macrophages by direct cationization Targeted delivery of superoxide dismutase to macrophages by direct cationization Proceedings of the Controlled Release Society, 22, 500-501 Proceedings of the Controlled Release Society, 22, 500-501 Proceedings of the Controlled Release Society, 22, 500-501 1995 英語 公開
T. Nomura; F. Yamashita; Y. Takakura; N. Hashida T. Nomura; F. Yamashita; Y. Takakura; N. Hashida T. Nomura; F. Yamashita; Y. Takakura; N. Hashida Pharmacokinetic analysis of various lipid carrier systems after intratumoral injection in tissue-isolated tumors Pharmacokinetic analysis of various lipid carrier systems after intratumoral injection in tissue-isolated tumors Pharmacokinetic analysis of various lipid carrier systems after intratumoral injection in tissue-isolated tumors Proceedings of the Controlled Release Society, 22, 420-421 Proceedings of the Controlled Release Society, 22, 420-421 Proceedings of the Controlled Release Society, 22, 420-421 1995 英語 公開
M. Nishikawa; F. Yamashita; Y. Takakura; M. Hashida M. Nishikawa; F. Yamashita; Y. Takakura; M. Hashida M. Nishikawa; F. Yamashita; Y. Takakura; M. Hashida Molecular design of protein derivatives targeted to the liver via the asialoglycoprotein receptor Molecular design of protein derivatives targeted to the liver via the asialoglycoprotein receptor Molecular design of protein derivatives targeted to the liver via the asialoglycoprotein receptor Proceedings of the Controlled Release Society, 22, 502-503 Proceedings of the Controlled Release Society, 22, 502-503 Proceedings of the Controlled Release Society, 22, 502-503 1995 英語 公開
H. Tokuda; S. Choksakulnimitr; S. Masuda; Y. Takakura; M. Hashida H. Tokuda; S. Choksakulnimitr; S. Masuda; Y. Takakura; M. Hashida H. Tokuda; S. Choksakulnimitr; S. Masuda; Y. Takakura; M. Hashida Uptake characteristics and cytotoxicity of plasmid DNA in cultured macrophages and endothelial cells Uptake characteristics and cytotoxicity of plasmid DNA in cultured macrophages and endothelial cells Uptake characteristics and cytotoxicity of plasmid DNA in cultured macrophages and endothelial cells Proceedings of the Controlled Release Society, 21, 244-245 Proceedings of the Controlled Release Society, 21, 244-245 Proceedings of the Controlled Release Society, 21, 244-245 1994 英語 公開
K. Kawabata; Y. Takakura; M. Hashida K. Kawabata; Y. Takakura; M. Hashida K. Kawabata; Y. Takakura; M. Hashida In vivo stability and disposition characteristics of plasmid DNA In vivo stability and disposition characteristics of plasmid DNA In vivo stability and disposition characteristics of plasmid DNA Proceedings of the Controlled Release Society, 21, 242-243 Proceedings of the Controlled Release Society, 21, 242-243 Proceedings of the Controlled Release Society, 21, 242-243 1994 英語 公開
F. Yamashita; Y. Koyama; Y. Takakura; M. Hashida F. Yamashita; Y. Koyama; Y. Takakura; M. Hashida F. Yamashita; Y. Koyama; Y. Takakura; M. Hashida Comparison of action mechanism of penetration enhancers based on a skin diffusion model Comparison of action mechanism of penetration enhancers based on a skin diffusion model Comparison of action mechanism of penetration enhancers based on a skin diffusion model Proceedings of the Controlled Release Society, 20, 424-425 Proceedings of the Controlled Release Society, 20, 424-425 Proceedings of the Controlled Release Society, 20, 424-425 1993 英語 公開
T. Miyao; Y. Takakura; M. Hashida T. Miyao; Y. Takakura; M. Hashida T. Miyao; Y. Takakura; M. Hashida Stability and in vivo disposition characteristics of oligonucleotides and oligonucleotide conjugated with macromolecule Stability and in vivo disposition characteristics of oligonucleotides and oligonucleotide conjugated with macromolecule Stability and in vivo disposition characteristics of oligonucleotides and oligonucleotide conjugated with macromolecule Proceedings of the Controlled Release Society, 20, 492-493 Proceedings of the Controlled Release Society, 20, 492-493 Proceedings of the Controlled Release Society, 20, 492-493 1993 英語 公開
H. Tokuda; Y. Takakura; M. Hashida H. Tokuda; Y. Takakura; M. Hashida H. Tokuda; Y. Takakura; M. Hashida Targeted delivery of polyanions to the brain Targeted delivery of polyanions to the brain Targeted delivery of polyanions to the brain Proceedings of the Controlled Release Society, 20, 270-271 Proceedings of the Controlled Release Society, 20, 270-271 Proceedings of the Controlled Release Society, 20, 270-271 1993 英語 公開

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タイトル言語:
書籍等出版物
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 出版社 出版社(日本語) 出版社(英語) 出版年月 記述言語 担当区分 公開
高倉 喜信 高倉 喜信 TAKAKURA Yoshinobu Diagnostic and Therapeutic Applications of Exosomes in Cance Diagnostic and Therapeutic Applications of Exosomes in Cance Diagnostic and Therapeutic Applications of Exosomes in Cance Elsevier Elsevier Elsevier 2018 英語 分担執筆 公開
高倉 喜信 高倉 喜信 くすりをつくる研究者の仕事 くすりをつくる研究者の仕事 化学同人 化学同人 2017 日本語 分担執筆 公開
高倉 喜信 高倉 喜信 パラダイムシフトをもたらすエクソソーム機能研究最前線 パラダイムシフトをもたらすエクソソーム機能研究最前線 NTS NTS 2017 日本語 分担執筆 公開
高倉 喜信 高倉 喜信 医療薬学 Ⅳ. 薬理・病態・薬物治療(4)(スタンダード薬学シリーズⅡ6) 医療薬学 Ⅳ. 薬理・病態・薬物治療(4)(スタンダード薬学シリーズⅡ6) 東京化学同人 東京化学同人 2017 日本語 分担執筆 公開
高倉 喜信 高倉 喜信 飛躍するDDSサイエンス 飛躍するDDSサイエンス Drug Delivery System, Drug Delivery System, 2017 日本語 その他 公開
高倉 喜信 高倉 喜信 TAKAKURA Yoshinobu Extracellular Vesicles Extracellular Vesicles Extracellular Vesicles Wiley Wiley Wiley 2017 英語 分担執筆 公開
高倉 喜信 高倉 喜信 核酸医薬の創製と応用展開 核酸医薬の創製と応用展開 シーエムシー シーエムシー 2016 日本語 分担執筆 公開
高倉 喜信 高倉 喜信 バイオマテリアル:その基礎と先端研究への展開 バイオマテリアル:その基礎と先端研究への展開 東京化学同人 東京化学同人 2016 日本語 分担執筆 公開
高倉 喜信 他 高倉 喜信 他 さらなるDDSの発展を目指して さらなるDDSの発展を目指して Drug Delivery System Drug Delivery System 2016 日本語 その他 公開
高倉 喜信 他 高倉 喜信 他 エクソソームを利用したDDSの開発 エクソソームを利用したDDSの開発 実験医学, 実験医学, 2016 日本語 その他 公開
高倉 喜信 高倉 喜信 DDS 最近の進歩 DDS 最近の進歩 ファルマシア ファルマシア 2016 日本語 その他 公開
高倉喜信 高倉喜信 薬剤学慨史-私はこう見る 120人による俯瞰図 薬剤学慨史-私はこう見る 120人による俯瞰図 日本薬剤学会 日本薬剤学会 2015 日本語 分担執筆 公開
高倉 喜信 高倉 喜信 10年後、20年後、そしてさらなる未来に向けて 10年後、20年後、そしてさらなる未来に向けて Drug Delivery System Drug Delivery System 2015 日本語 その他 公開
高倉 喜信 高倉 喜信 新薬展望2015 第1部 新薬創出における日本医療研究開発機構(AMED)の役割 新薬展望2015 第1部 新薬創出における日本医療研究開発機構(AMED)の役割 医薬ジャーナル 医薬ジャーナル 2015 日本語 その他 公開
高倉 喜信 他 高倉 喜信 他 ハイドロダイナミクス法:高効率なin vivo遺伝子導入法 ハイドロダイナミクス法:高効率なin vivo遺伝子導入法 実験医学 実験医学 2015 日本語 その他 公開
高倉 喜信 高倉 喜信 発刊によせて 発刊によせて ファームテクジャパン ファームテクジャパン 2015 日本語 その他 公開
高倉 喜信 他 高倉 喜信 他 核酸医薬のための次世代DDS開発 核酸医薬のための次世代DDS開発 ファームテクジャパン ファームテクジャパン 2015 日本語 その他 公開
高倉 喜信 他 高倉 喜信 他 ドラッグデリバリーシステムとしてのエキソソーム ドラッグデリバリーシステムとしてのエキソソーム 細胞 細胞 2015 日本語 その他 公開
高倉 喜信 他 高倉 喜信 他 核酸医薬のためのデリバリー技術 核酸医薬のためのデリバリー技術 日本核酸医薬学会会誌 日本核酸医薬学会会誌 2015 日本語 その他 公開
高倉喜信 高倉喜信 薬剤学実験法必携マニュアル―(分担執筆) 薬剤学実験法必携マニュアル―(分担執筆) 南江堂 南江堂 2014/04 日本語 分担執筆 公開
高倉 喜信 他 高倉 喜信 他 細胞スフェロイド化技術の開発と細胞治療への応用 細胞スフェロイド化技術の開発と細胞治療への応用 Drug Delivery System Drug Delivery System 2014 日本語 その他 公開
高倉 喜信 高倉 喜信 30周年を迎えて 30周年を迎えて Drug Delivery System Drug Delivery System 2014 日本語 その他 公開
高倉 喜信 高倉 喜信 バイオ薬医の動態制御 バイオ薬医の動態制御 薬剤学 薬剤学 2014 日本語 その他 公開
高倉 喜信 他 高倉 喜信 他 オリゴ核酸を基盤とする多足型核酸構造体を利用した免疫刺激性核酸デリバリーシステムの開発 オリゴ核酸を基盤とする多足型核酸構造体を利用した免疫刺激性核酸デリバリーシステムの開発 Antisense Antisense 2014 日本語 その他 公開
高倉 喜信 高倉 喜信 応用が拡がるDDSー人体環境から農業・家電までー(分担執筆) 応用が拡がるDDSー人体環境から農業・家電までー(分担執筆) NTS NTS 2013 日本語 分担執筆 公開
高倉 喜信 高倉 喜信 日本のプレセンスを! 日本のプレセンスを! Drug Delivery System Drug Delivery System 2013 日本語 その他 公開
高倉 喜信 高倉 喜信 細胞治療とDDS-細胞を制御する、細胞で制御するー 細胞治療とDDS-細胞を制御する、細胞で制御するー Drug Delivery System Drug Delivery System 2013 日本語 その他 公開
高倉 喜信 高倉 喜信 新しい薬学事典(分担執筆) 新しい薬学事典(分担執筆) 朝倉書店 朝倉書店 2012 日本語 分担執筆 公開
高倉 喜信 高倉 喜信 昇り竜のごとく 昇り竜のごとく Drug Delivery System Drug Delivery System 2012 日本語 その他 公開
高倉 喜信 高倉 喜信 薬剤学研究の将来ー薬学教育6年制導入から6年ー 薬剤学研究の将来ー薬学教育6年制導入から6年ー 薬剤学 薬剤学 2012 日本語 その他 公開
高倉 喜信 他 高倉 喜信 他 RNA干渉を利用した疾患治療システム RNA干渉を利用した疾患治療システム 生体の科学 生体の科学 2012 日本語 その他 公開
高倉 喜信 他 高倉 喜信 他 遺伝子・細胞製剤フォーカスグループの活動について 遺伝子・細胞製剤フォーカスグループの活動について 薬剤学 薬剤学 2012 日本語 その他 公開
高倉 喜信 高倉 喜信 アジュバンド開発研究の新展開(分担執筆) アジュバンド開発研究の新展開(分担執筆) シーエム-シー シーエム-シー 2011 日本語 分担執筆 公開
高倉 喜信 高倉 喜信 次世代バイオ医薬品の製剤設計と開発戦略(分担執筆) 次世代バイオ医薬品の製剤設計と開発戦略(分担執筆) シーエムーシ シーエムーシ 2011 日本語 分担執筆 公開
高倉 喜信 高倉 喜信 DDSのさらなる発展のために DDSのさらなる発展のために Drug Delivery System Drug Delivery System 2011 日本語 その他 公開
高倉喜信 高倉喜信 図解で学ぶDDS―薬物治療の最適化を目指す先端創薬技術(編集) 図解で学ぶDDS―薬物治療の最適化を目指す先端創薬技術(編集) じほう じほう 2010/08 日本語 公開
高倉 喜信 高倉 喜信 TAKAKURA Yoshinobu Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development, Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development, Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development, Informa Healthcare Informa Healthcare Informa Healthcare 2009 英語 分担執筆 公開
高倉 喜信 高倉 喜信 TAKAKURA Yoshinobu Drug Delivery: Principles and Applications Drug Delivery: Principles and Applications Drug Delivery: Principles and Applications Wiley Wiley Wiley 2005 英語 分担執筆 公開
高倉 喜信 高倉 喜信 TAKAKURA Yoshinobu Polymeric Gene Delivery Principles and Applications Polymeric Gene Delivery Principles and Applications Polymeric Gene Delivery Principles and Applications CRC Press CRC Press CRC Press 2005 英語 分担執筆 公開
高倉 喜信 高倉 喜信 TAKAKURA Yoshinobu Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics Taylor & Francis Taylor & Francis 2002 英語 分担執筆 公開
橋田 充, 高倉 喜信 橋田 充, 高倉 喜信 生体内薬物送達学 (基礎生体工学講座)(共著) 生体内薬物送達学 (基礎生体工学講座)(共著) 産業図書 産業図書 1994/10 日本語 共著 公開
髙倉 喜信 髙倉 喜信 バイオコンジュゲート医薬品(分担執筆) バイオコンジュゲート医薬品(分担執筆) 廣川書店, 廣川書店, 1993 日本語 公開

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タイトル言語:
学術賞等
賞の名称(日本語) 賞の名称(英語) 授与組織名(日本語) 授与組織名(英語) 年月
日本薬物動態学会奨励賞 1995
日本薬学会奨励賞 1996
AAPSフェロー 2009
タケル・アヤ・ヒグチ記念賞 2011
外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
基盤研究(B) 代表 機能改変タンパク質および核酸を基盤とした包括的抗腫瘍免疫治療システムの開発  2007〜2008
萌芽研究 代表 抗原投与を全く必要としない細胞内抗原トラップ型新規腫瘍ワクチンの開発 2007〜2008/__/__
挑戦的萌芽研究 代表 遺伝子発現再活性化現象を利用したリピータブルタンパク質発現システムの開発 2009〜2009
特定領域研究 代表 インターフェロン遺伝子発現の増強・持続化による新規癌治療戦略 2008〜2009
厚生労働科学研究費 分担 ヒト肝細胞キメラマウスを用いた治療抵抗性の肝炎に関する研究  2008〜2010
基盤研究(B) 代表 治療用タンパク・siRNA発現の時空間制御のためのプラスミドデザインとデリバリー 2009〜2011
挑戦的萌芽研究 代表 一回の投与で繰り返しタンパク質を供給可能なオンデマンド型遺伝子治療システムの開発 2010〜2010
厚生労働科学研究費 分担 創薬と新規治療法に開発に資するヒト肝細胞キメラマウスを用いた肝炎ウィルス制御に関する研究 2011〜2013
基盤研究(B) 分担 多足型構造を形成する核酸を基盤とする核酸ナノDDS開発 2011〜2015/03/31
挑戦的萌芽研究 分担 細胞個性に立脚したターゲティング型細胞治療システムの開発 2011〜2012
基盤研究(B) 代表 転写・翻訳/体内動態/細胞応答の三元制御に基づくサイトカイン遺伝子治療の最適化  2012〜2014
基盤研究(B) 代表 転写・翻訳/体内動態/細胞応答の三元制御に基づくサイトカイン遺伝(平成26年度) 2014〜2015
挑戦的萌芽研究 分担 RNA医薬を搭載した標的指向型多機能性エキソソームの開発 2012〜2013
挑戦的萌芽研究 分担 混合型細胞スフェロイド化技術を駆使した高機能微小組織移植治療システムの開発 2013〜2013
挑戦的萌芽研究 代表 自己粒子化RNAスポンジを利用した免疫療法用DDS開発 2014/04/01〜2016/03/31
挑戦的萌芽研究 分担 エキソソーム指向性siRNA誘導体の設計による生体内RNA干渉の効率的誘導 2014〜2015
基盤研究(B) 分担 3次元構ナノDNA造体を基本ユニットとする疾患治療システムの開発(平成26・27年度分) 2014〜
基盤研究(B) 代表 遺伝子発現と生体応答の包括的制御による治療係数の高いサイトカン遺伝子治療法開発 2015〜
基盤研究(B) 代表 遺伝子発現と生体応答の包括的制御による治療係数の高いサイトカイン遺伝子治療法開発 (平成27年度分) 2015/04/01〜2016/03/31
挑戦的萌芽研究 代表 自己粒子化RNAスポンジを利用した免疫療法用DDS開発 (平成27年度分) 2015/04/01〜2016/03/31
基盤研究(B) 代表 遺伝子発現と生体応答の包括的制御による治療係数の高いサイトカイン遺伝子治療法開発 (平成28年度分) 2016/04/01〜2017/03/31
基盤研究(B) 代表 遺伝子発現と生体応答の包括的制御による治療係数の高いサイトカイン遺伝子治療法開発 (平成29年度分) 2017/04/01〜2018/03/31

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外部資金:競争的資金・科学研究費補助金以外
制度名 代表者名 研究課題(日本語) 研究課題(英語) 期間
細胞特異的薬物送達に関する研究 Study on Cell Specific Drug Delivery
遺伝子治療における製剤設計に関する研究 Study on Dosage Form Design for Gene Therapy
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
医療実務事前学習 後期前期 薬学部 2011/04〜2012/03
医療薬学III(薬物動態学) 後期 薬学部 2011/04〜2012/03
特別実習(病態情報薬学) 通年 薬学部 2011/04〜2012/03
薬剤学3(薬物動態学) 後期 薬学部 2011/04〜2012/03
医薬品開発プロジェクト演習I 前期 薬学部 2011/04〜2012/03
統合型薬学演習 後期 薬学部 2011/04〜2012/03
特別実習[病態情報薬学] 通年 薬学部 2011/04〜2012/03
薬局実務実習 通年 薬学部 2011/04〜2012/03
基盤医療薬科学概論 Introduction to Basic Pharmacy and Biomedical Sciences 前期不定 薬学研究科 2011/04〜2012/03
病態情報薬学実験 Research in Biopharmaceutics and Drug Metabolism 通年不定 薬学研究科 2011/04〜2012/03
病態機能解析学実習 Advanced Methods in Pharmacodynamic Sciences 通年不定 薬学研究科 2011/04〜2012/03
病態情報薬学演習 Biopharmaceutics and Drug Metabolism Seminar 通年不定 薬学研究科 2011/04〜2012/03
薬と医療 Pharmaceuticals and Medicine 前期 全学共通科目 2011/04〜2012/03
先端医療SGD演習 前期 薬学部 2011/04〜2012/03
共用試験関係 通年 薬学部 2011/04〜2012/03
医療倫理実習 後期 薬学部 2011/04〜2012/03
地域医療薬学 前期 薬学部 2011/04〜2012/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and 前期不定 薬学研究科 2011/04〜2012/03
基盤医療薬科学実験技術(秋入学用) Basic Laboratory Techniques in Pharmacy and 後期不定 薬学研究科 2011/04〜2012/03
基盤病態機能解析学実習 Laboratory Practice in Basic Pharmacodynanic Sciences 通年不定 薬学研究科 2011/04〜2012/03
基盤病態機能解析学実験 Research in Basic Pharmacodynanic Sciences 通年不定 薬学研究科 2011/04〜2012/03
基盤病態機能解析学演習 Seminar in Basic Patho-Functional Analysis 通年不定 薬学研究科 2011/04〜2012/03
病院実務実習 通年 薬学部 2011/04〜2012/03
臨床薬学総論 後期 薬学部 2011/04〜2012/03
薬学倫理・概論 An Introduction to Pharmaceutical Sciences and Ethics 前期 全学共通科目 2011/04〜2012/03
先端医療SGD演習 Frontier SGD Classes for Clinical Pharmacy 前期 薬学部 2012/04〜2013/03
医療倫理実習 Laboratory for medical ethics 後期 薬学部 2012/04〜2013/03
医療実務事前学習 Pre-Training for Clinical Clerkship 後期前期 薬学部 2012/04〜2013/03
医療薬学III(薬物動態学) Medicinal Pharmacy III(Biopharmaceutics) 後期 薬学部 2012/04〜2013/03
医薬品開発プロジェクト演習I Pharmaceutical R&D Exercise I 前期 薬学部 2012/04〜2013/03
博士後期課程特論 doctoral program 前期集中 薬学研究科 2012/04〜2013/03
博士後期課程特論 doctoral program 後期集中 薬学研究科 2012/04〜2013/03
地域医療薬学 Community Clinical Pharmacy 前期 薬学部 2012/04〜2013/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 前期不定 薬学研究科 2012/04〜2013/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 後期不定 薬学研究科 2012/04〜2013/03
基盤医療薬科学概論 Introduction to Basic Pharmacy and Biomedical Sciences 前期不定 薬学研究科 2012/04〜2013/03
基盤医療薬科学特論I Advanced Basic Pharmacy and Biomedicinal Sciences I 後期不定 薬学研究科 2012/04〜2013/03
基盤病態機能解析学実習 Laboratory Practice in Basic Pharmacodynanic Sciences 通年不定 薬学研究科 2012/04〜2013/03
基盤病態機能解析学実験 Research in Basic Pharmacodynanic Sciences 通年不定 薬学研究科 2012/04〜2013/03
基盤病態機能解析学演習 Seminar in Basic Patho-Functional Analysis 通年不定 薬学研究科 2012/04〜2013/03
特別実習[病態情報薬学] Research Training(Biopharmaceutics and Drug Metabolism) 通年 薬学部 2012/04〜2013/03
特別実習(病態情報薬学) Research Training(Biopharmaceutics and Drug Metabolism) 通年 薬学部 2012/04〜2013/03
病院実務実習 Clinical Clerkship in Hospital Pharmacy 通年 薬学部 2012/04〜2013/03
統合型薬学演習 Integrated Pharmaceutical Exercise 後期 薬学部 2012/04〜2013/03
臨床薬学総論 Introduction to Clinical Pharmacy 後期 薬学部 2012/04〜2013/03
薬剤学3(薬物動態学) Medicinal Pharmacy 3 (Biopharmaceutics) 後期 薬学部 2012/04〜2013/03
薬学倫理・概論 An Introduction to Pharmaceutical Sciences and Ethics 前期 全学共通科目 2012/04〜2013/03
薬学実験技術 Basic Laboratory Techniques in Pharmaceutical Sciences 前期不定 薬学研究科 2012/04〜2013/03
薬学研究実験Ⅲ Research in Pharmaceutical Sciences III 通年不定 薬学研究科 2012/04〜2013/03
薬学研究実験Ⅱ Research in Pharmaceutical Sciences II 通年不定 薬学研究科 2012/04〜2013/03
薬学研究実験Ⅰ Research in Pharmaceutical Sciences I 通年不定 薬学研究科 2012/04〜2013/03
薬学研究概論 Introduction to Pharmaceutical Sciences 前期不定 薬学研究科 2012/04〜2013/03
薬学研究演習Ⅲ Seminar for Pharmaceutical Sciences III 通年不定 薬学研究科 2012/04〜2013/03
薬学研究演習Ⅱ Seminar for Pharmaceutical Sciences II 通年不定 薬学研究科 2012/04〜2013/03
薬学研究演習Ⅰ Seminar for Pharmaceutical Sciences I 通年不定 薬学研究科 2012/04〜2013/03
薬学研究特論Ⅰ Advanced Pharmaceutical Sciences I 後期不定 薬学研究科 2012/04〜2013/03
薬局実務実習 Clinical Clerkship in Community Pharmacy 通年 薬学部 2012/04〜2013/03
特別実習(病態情報薬学) Research Training(Biopharmaceutics and Drug Metabolism) 通年 薬学部 2013/04〜2014/03
薬剤学3(薬物動態学) Medicinal Pharmacy 3 (Biopharmaceutics) 後期 薬学部 2013/04〜2014/03
医薬品開発プロジェクト演習I Pharmaceutical R&D Exercise I 前期 薬学部 2013/04〜2014/03
統合型薬学演習 Integrated Pharmaceutical Exercise 後期 薬学部 2013/04〜2014/03
医療倫理実習 Laboratory for medical ethics 後期 薬学部 2013/04〜2014/03
先端医療SGD演習 Frontier SGD Classes for Clinical Pharmacy 前期 薬学部 2013/04〜2014/03
地域医療薬学 Community Clinical Pharmacy 前期 薬学部 2013/04〜2014/03
医療実務事前学習 Pre-Training for Clinical Clerkship 後期前期 薬学部 2013/04〜2014/03
臨床薬学総論 Introduction to Clinical Pharmacy 後期 薬学部 2013/04〜2014/03
特別実習[病態情報薬学] Research Training(Biopharmaceutics and Drug Metabolism) 通年 薬学部 2013/04〜2014/03
病院実務実習 Clinical Clerkship in Hospital Pharmacy 通年 薬学部 2013/04〜2014/03
薬局実務実習 Clinical Clerkship in Community Pharmacy 通年 薬学部 2013/04〜2014/03
基盤医療薬科学概論 Introduction to Basic Pharmacy and Biomedical Sciences 前期不定 薬学研究科 2013/04〜2014/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 前期不定 薬学研究科 2013/04〜2014/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 後期不定 薬学研究科 2013/04〜2014/03
基盤病態機能解析学演習 Seminar in Basic Patho-Functional Analysis 通年不定 薬学研究科 2013/04〜2014/03
基盤病態機能解析学実験 Research in Basic Pharmacodynanic Sciences 通年不定 薬学研究科 2013/04〜2014/03
基盤病態機能解析学実習 Laboratory Practice in Basic Pharmacodynanic Sciences 通年不定 薬学研究科 2013/04〜2014/03
薬学研究概論 Introduction to Pharmaceutical Sciences 前期不定 薬学研究科 2013/04〜2014/03
薬学実験技術 Basic Laboratory Techniques in Pharmaceutical Sciences 前期不定 薬学研究科 2013/04〜2014/03
薬学研究特論Ⅰ Advanced Pharmaceutical Sciences I 後期不定 薬学研究科 2013/04〜2014/03
薬学研究演習Ⅰ Seminar for Pharmaceutical Sciences I 通年不定 薬学研究科 2013/04〜2014/03
薬学研究演習Ⅱ Seminar for Pharmaceutical Sciences II 通年不定 薬学研究科 2013/04〜2014/03
薬学研究演習Ⅲ Seminar for Pharmaceutical Sciences III 通年不定 薬学研究科 2013/04〜2014/03
薬学研究実験Ⅰ Research in Pharmaceutical Sciences I 通年不定 薬学研究科 2013/04〜2014/03
薬学研究実験Ⅱ Research in Pharmaceutical Sciences II 通年不定 薬学研究科 2013/04〜2014/03
薬学研究実験Ⅲ Research in Pharmaceutical Sciences III 通年不定 薬学研究科 2013/04〜2014/03
博士後期課程特論 doctoral program 前期集中 薬学研究科 2013/04〜2014/03
博士後期課程特論 doctoral program 後期集中 薬学研究科 2013/04〜2014/03
薬学倫理・概論 An Introduction to Pharmaceutical Sciences and Ethics 前期 全学共通科目 2013/04〜2014/03
薬と医療 Pharmaceuticals and Medicine 前期 全学共通科目 2013/04〜2014/03
特別実習(病態情報薬学) Research Training(Biopharmaceutics and Drug Metabolism) 通年 薬学部 2014/04〜2015/03
薬剤学3(薬物動態学) Medicinal Pharmacy 3 (Biopharmaceutics) 後期 薬学部 2014/04〜2015/03
医薬品開発プロジェクト演習I Pharmaceutical R&D Exercise I 前期 薬学部 2014/04〜2015/03
統合型薬学演習 Integrated Pharmaceutical Exercise 後期 薬学部 2014/04〜2015/03
医療倫理実習 Laboratory for medical ethics 後期 薬学部 2014/04〜2015/03
先端医療SGD演習 Frontier SGD Classes for Clinical Pharmacy 前期 薬学部 2014/04〜2015/03
地域医療薬学 Community Clinical Pharmacy 前期 薬学部 2014/04〜2015/03
医療実務事前学習 Pre-Training for Clinical Clerkship 後期前期 薬学部 2014/04〜2015/03
臨床薬学総論 Introduction to Clinical Pharmacy 後期 薬学部 2014/04〜2015/03
特別実習[病態情報薬学] Research Training(Biopharmaceutics and Drug Metabolism) 通年 薬学部 2014/04〜2015/03
病院実務実習 Clinical Clerkship in Hospital Pharmacy 通年 薬学部 2014/04〜2015/03
薬局実務実習 Clinical Clerkship in Community Pharmacy 通年 薬学部 2014/04〜2015/03
薬物動態学(LIMS) Biopharmaceutics 後期集中 医学研究科 2014/04〜2015/03
基盤医療薬科学概論 Introduction to Basic Pharmacy and Biomedical Sciences 前期不定 薬学研究科 2014/04〜2015/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 前期不定 薬学研究科 2014/04〜2015/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 後期不定 薬学研究科 2014/04〜2015/03
基盤医療薬科学特論I Advanced Basic Pharmacy and Biomedicinal Sciences I 後期不定 薬学研究科 2014/04〜2015/03
基盤病態機能解析学演習 Seminar in Basic Patho-Functional Analysis 通年不定 薬学研究科 2014/04〜2015/03
基盤病態機能解析学演習 Seminar in Basic Patho-Functional Analysis 後期前期 薬学研究科 2014/04〜2015/03
基盤病態機能解析学実験 Research in Basic Pharmacodynanic Sciences 通年不定 薬学研究科 2014/04〜2015/03
基盤病態機能解析学実験 Research in Basic Pharmacodynanic Sciences 後期前期 薬学研究科 2014/04〜2015/03
基盤病態機能解析学実習 Laboratory Practice in Basic Pharmacodynanic Sciences 通年不定 薬学研究科 2014/04〜2015/03
基盤病態機能解析学実習 Laboratory Practice in Basic Pharmacodynanic Sciences 後期前期 薬学研究科 2014/04〜2015/03
薬学研究概論 Introduction to Pharmaceutical Sciences 前期不定 薬学研究科 2014/04〜2015/03
薬学実験技術 Basic Laboratory Techniques in Pharmaceutical Sciences 前期不定 薬学研究科 2014/04〜2015/03
薬学研究特論Ⅰ Advanced Pharmaceutical Sciences I 後期不定 薬学研究科 2014/04〜2015/03
薬学研究演習Ⅰ Seminar for Pharmaceutical Sciences I 通年不定 薬学研究科 2014/04〜2015/03
薬学研究演習Ⅱ Seminar for Pharmaceutical Sciences II 通年不定 薬学研究科 2014/04〜2015/03
薬学研究演習Ⅲ Seminar for Pharmaceutical Sciences III 通年不定 薬学研究科 2014/04〜2015/03
薬学研究実験Ⅰ Research in Pharmaceutical Sciences I 通年不定 薬学研究科 2014/04〜2015/03
薬学研究実験Ⅱ Research in Pharmaceutical Sciences II 通年不定 薬学研究科 2014/04〜2015/03
薬学研究実験Ⅲ Research in Pharmaceutical Sciences III 通年不定 薬学研究科 2014/04〜2015/03
薬物動態学 Biopharmaceutics 後期 工学研究科 2014/04〜2015/03
薬学倫理・概論 An Introduction to Pharmaceutical Sciences and Ethics 前期 全学共通科目 2014/04〜2015/03
医療倫理実習 Laboratory for medical ethics 後期 薬学部 2015/04〜2016/03
医療実務事前学習 Pre-Training for Clinical Clerkship 後期前期 薬学部 2015/04〜2016/03
医薬品開発プロジェクト演習I Pharmaceutical R&D Exercise I 前期 薬学部 2015/04〜2016/03
地域医療薬学 Community Clinical Pharmacy 前期 薬学部 2015/04〜2016/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 前期不定 薬学研究科 2015/04〜2016/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 後期不定 薬学研究科 2015/04〜2016/03
基盤医療薬科学概論 Introduction to Basic Pharmacy and Biomedical Sciences 前期不定 薬学研究科 2015/04〜2016/03
基盤病態機能解析学実習 Laboratory Practice in Basic Pharmacodynanic Sciences 後期前期 薬学研究科 2015/04〜2016/03
基盤病態機能解析学実習 Laboratory Practice in Basic Pharmacodynanic Sciences 通年不定 薬学研究科 2015/04〜2016/03
基盤病態機能解析学実験 Research in Basic Pharmacodynanic Sciences 後期前期 薬学研究科 2015/04〜2016/03
基盤病態機能解析学実験 Research in Basic Pharmacodynanic Sciences 通年不定 薬学研究科 2015/04〜2016/03
基盤病態機能解析学演習 Seminar in Basic Patho-Functional Analysis 後期前期 薬学研究科 2015/04〜2016/03
基盤病態機能解析学演習 Seminar in Basic Patho-Functional Analysis 通年不定 薬学研究科 2015/04〜2016/03
特別実習[病態情報薬学] Research Training(Biopharmaceutics and Drug Metabolism) 通年 薬学部 2015/04〜2016/03
特別実習(病態情報薬学) Research Training(Biopharmaceutics and Drug Metabolism) 通年 薬学部 2015/04〜2016/03
病院実務実習 Clinical Clerkship in Hospital Pharmacy 通年 薬学部 2015/04〜2016/03
統合型薬学演習 Integrated Pharmaceutical Exercise 後期 薬学部 2015/04〜2016/03
臨床薬学総論 Introduction to Clinical Pharmacy 後期 薬学部 2015/04〜2016/03
薬剤学3(薬物動態学) Medicinal Pharmacy 3 (Biopharmaceutics) 後期 薬学部 2015/04〜2016/03
薬学倫理・概論 An Introduction to Pharmaceutical Sciences and Ethics 前期 全学共通科目 2015/04〜2016/03
薬学実験技術 Basic Laboratory Techniques in Pharmaceutical Sciences 前期不定 薬学研究科 2015/04〜2016/03
薬学研究実験Ⅲ Research in Pharmaceutical Sciences III 通年不定 薬学研究科 2015/04〜2016/03
薬学研究実験Ⅱ Research in Pharmaceutical Sciences II 通年不定 薬学研究科 2015/04〜2016/03
薬学研究実験Ⅰ Research in Pharmaceutical Sciences I 通年不定 薬学研究科 2015/04〜2016/03
薬学研究概論 Introduction to Pharmaceutical Sciences 前期不定 薬学研究科 2015/04〜2016/03
薬学研究演習Ⅲ Seminar for Pharmaceutical Sciences III 通年不定 薬学研究科 2015/04〜2016/03
薬学研究演習Ⅱ Seminar for Pharmaceutical Sciences II 通年不定 薬学研究科 2015/04〜2016/03
薬学研究演習Ⅰ Seminar for Pharmaceutical Sciences I 通年不定 薬学研究科 2015/04〜2016/03
薬学研究特論Ⅰ Advanced Pharmaceutical Sciences I 後期不定 薬学研究科 2015/04〜2016/03
薬局実務実習 Clinical Clerkship in Community Pharmacy 通年 薬学部 2015/04〜2016/03
薬物動態学 Biopharmaceutics 後期 工学研究科 2015/04〜2016/03
薬物動態学(LIMS) Biopharmaceutics 後期集中 医学研究科 2015/04〜2016/03
ILASセミナー ILAS Seminar 前期 全学共通科目 2016/04〜2017/03
医療実務事前学習 Pre-Training for Clinical Clerkship 後期前期 薬学部 2016/04〜2017/03
医薬品開発プロジェクト演習I Pharmaceutical R&D Exercise I 前期 薬学部 2016/04〜2017/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 前期不定 薬学研究科 2016/04〜2017/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 後期不定 薬学研究科 2016/04〜2017/03
基盤医療薬科学概論 Introduction to Basic Pharmacy and Biomedical Sciences 前期不定 薬学研究科 2016/04〜2017/03
基盤医療薬科学特論I Advanced Basic Pharmacy and Biomedicinal Sciences I 後期不定 薬学研究科 2016/04〜2017/03
基盤病態機能解析学実習 Laboratory Practice in Basic Pharmacodynanic Sciences 通年不定 薬学研究科 2016/04〜2017/03
基盤病態機能解析学実験 Research in Basic Pharmacodynanic Sciences 通年不定 薬学研究科 2016/04〜2017/03
基盤病態機能解析学演習 Seminar in Basic Patho-Functional Analysis 通年不定 薬学研究科 2016/04〜2017/03
特別実習[病態情報薬学] Research Training(Biopharmaceutics and Drug Metabolism) 通年 薬学部 2016/04〜2017/03
特別実習(病態情報薬学) Research Training(Biopharmaceutics and Drug Metabolism) 通年 薬学部 2016/04〜2017/03
特別実習[臨床薬学教育] Research Training(Clinical Pharmacy and Education) 通年 薬学部 2016/04〜2017/03
病院実務実習 Clinical Clerkship in Hospital Pharmacy 通年 薬学部 2016/04〜2017/03
統合型薬学演習 Integrated Pharmaceutical Exercise 後期 薬学部 2016/04〜2017/03
臨床薬学総論 Introduction to Clinical Pharmacy 後期 薬学部 2016/04〜2017/03
「薬の世界」入門 Introduction to Pharmaceutical Sciences and Ethics 前期 全学共通科目 2016/04〜2017/03
薬剤学3(薬物動態学) Medicinal Pharmacy 3 (Biopharmaceutics) 後期 薬学部 2016/04〜2017/03
薬学実験技術 Basic Laboratory Techniques in Pharmaceutical Sciences 前期不定 薬学研究科 2016/04〜2017/03
薬学研究実験Ⅲ Research in Pharmaceutical Sciences III 通年不定 薬学研究科 2016/04〜2017/03
薬学研究実験Ⅱ Research in Pharmaceutical Sciences II 通年不定 薬学研究科 2016/04〜2017/03
薬学研究実験Ⅰ Research in Pharmaceutical Sciences I 通年不定 薬学研究科 2016/04〜2017/03
薬学研究概論 Introduction to Pharmaceutical Sciences 前期不定 薬学研究科 2016/04〜2017/03
薬学研究演習Ⅲ Seminar for Pharmaceutical Sciences III 通年不定 薬学研究科 2016/04〜2017/03
薬学研究演習Ⅱ Seminar for Pharmaceutical Sciences II 通年不定 薬学研究科 2016/04〜2017/03
薬学研究演習Ⅰ Seminar for Pharmaceutical Sciences I 通年不定 薬学研究科 2016/04〜2017/03
薬学研究特論Ⅰ Advanced Pharmaceutical Sciences I 後期不定 薬学研究科 2016/04〜2017/03
薬局実務実習 Clinical Clerkship in Community Pharmacy 通年 薬学部 2016/04〜2017/03
薬物動態学 Biopharmaceutics 後期 工学研究科 2016/04〜2017/03
薬物動態学(LIMS) Biopharmaceutics 後期集中 医学研究科 2016/04〜2017/03
創薬医療薬科学概論 Introduction to Pharmacy and Biomedical Sciences for Drug Discovery 前期不定 薬学研究科 2017/04〜2018/03
医療実務事前学習 Pre-Training for Clinical Clerkship 後期前期 薬学部 2017/04〜2018/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 前期不定 薬学研究科 2017/04〜2018/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 後期不定 薬学研究科 2017/04〜2018/03
基盤病態機能解析学実習 Laboratory Practice in Basic Pharmacodynanic Sciences 通年不定 薬学研究科 2017/04〜2018/03
基盤病態機能解析学実験 Research in Basic Pharmacodynanic Sciences 通年不定 薬学研究科 2017/04〜2018/03
基盤病態機能解析学演習 Seminar in Basic Patho-Functional Analysis 通年不定 薬学研究科 2017/04〜2018/03
特別実習[病態情報薬学] Research Training(Biopharmaceutics and Drug Metabolism) 通年 薬学部 2017/04〜2018/03
特別実習(病態情報薬学) Research Training(Biopharmaceutics and Drug Metabolism) 通年 薬学部 2017/04〜2018/03
病院実務実習 Clinical Clerkship in Hospital Pharmacy 通年 薬学部 2017/04〜2018/03
統合型薬学演習 Integrated Pharmaceutical Exercise 後期 薬学部 2017/04〜2018/03
統合科学 Interdisciplinary Sciences 後期 全学共通科目 2017/04〜2018/03
臨床薬学概論 Introduction to Clinical Pharmacy 前期不定 薬学研究科 2017/04〜2018/03
臨床薬学総論 Introduction to Clinical Pharmacy 後期 薬学部 2017/04〜2018/03
「薬の世界」入門 Introduction to Pharmaceutical Sciences and Ethics 前期 全学共通科目 2017/04〜2018/03
薬剤学3(薬物動態学) Medicinal Pharmacy 3 (Biopharmaceutics) 後期 薬学部 2017/04〜2018/03
薬学実験技術 Basic Laboratory Techniques in Pharmaceutical Sciences 前期不定 薬学研究科 2017/04〜2018/03
薬学研究実験Ⅲ Research in Pharmaceutical Sciences III 通年不定 薬学研究科 2017/04〜2018/03
薬学研究実験Ⅱ Research in Pharmaceutical Sciences II 通年不定 薬学研究科 2017/04〜2018/03
薬学研究実験Ⅰ Research in Pharmaceutical Sciences I 通年不定 薬学研究科 2017/04〜2018/03
薬学研究概論 Introduction to Pharmaceutical Sciences 前期不定 薬学研究科 2017/04〜2018/03
薬学研究演習Ⅲ Seminar for Pharmaceutical Sciences III 通年不定 薬学研究科 2017/04〜2018/03
薬学研究演習Ⅱ Seminar for Pharmaceutical Sciences II 通年不定 薬学研究科 2017/04〜2018/03
薬学研究演習Ⅰ Seminar for Pharmaceutical Sciences I 通年不定 薬学研究科 2017/04〜2018/03
薬学研究特論Ⅰ Advanced Pharmaceutical Sciences I 後期不定 薬学研究科 2017/04〜2018/03
薬局実務実習 Clinical Clerkship in Community Pharmacy 通年 薬学部 2017/04〜2018/03
薬物動態学 Biopharmaceutics 後期 工学研究科 2017/04〜2018/03
薬物動態学(LIMS) Biopharmaceutics (LIMS) 後期集中 医学研究科 2017/04〜2018/03
共用試験関係 通年 薬学部 2018/04〜2019/03
創薬医療薬科学概論 Introduction to Pharmacy and Biomedical Sciences for Drug Discovery 前期不定 薬学研究科 2018/04〜2019/03
創薬リード探索技術 Drug Discovery & Development II: Lead Discovery Technology 後期不定 薬学研究科 2018/04〜2019/03
創薬リード探索理論 Bioinformatics II: Lead Discovery 前期不定 薬学研究科 2018/04〜2019/03
創薬有機化学概論 Introduction to Organic Chemistry for Drug Discovery 前期不定 薬学研究科 2018/04〜2019/03
創薬物理化学概論 Introduction to Physical Chemistry for Drug Discovery 前期不定 薬学研究科 2018/04〜2019/03
創薬生命科学概論 Introduction to Modern Life Sciences for Drug Discovery 前期不定 薬学研究科 2018/04〜2019/03
医療実務事前学習 Pre-Training for Clinical Clerkship 後期 薬学部 2018/04〜2019/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 前期不定 薬学研究科 2018/04〜2019/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 後期不定 薬学研究科 2018/04〜2019/03
基盤医療薬科学特論I Advanced Basic Pharmacy and Biomedicinal Sciences I 後期不定 薬学研究科 2018/04〜2019/03
基盤有機化学特論II Advanced Basic Organic Chemistry II 後期不定 薬学研究科 2018/04〜2019/03
基盤物理化学特論I Advanced Basic Physical Chemistry I 前期不定 薬学研究科 2018/04〜2019/03
基盤生物化学特論II Advanced Basic Biological Chemistry II 前期不定 薬学研究科 2018/04〜2019/03
基盤病態機能解析学実習 Laboratory Practice in Basic Pharmacodynanic Sciences 通年不定 薬学研究科 2018/04〜2019/03
基盤病態機能解析学実験 Research in Basic Pharmacodynanic Sciences 通年不定 薬学研究科 2018/04〜2019/03
基盤病態機能解析学演習 Seminar in Basic Patho-Functional Analysis 通年不定 薬学研究科 2018/04〜2019/03
実務実習 通年 薬学部 2018/04〜2019/03
特別実習[病態情報薬学] Research Training(Biopharmaceutics and Drug Metabolism) 通年 薬学部 2018/04〜2019/03
特別実習(病態情報薬学) Research Training(Biopharmaceutics and Drug Metabolism) 通年 薬学部 2018/04〜2019/03
病院実務実習 Clinical Clerkship in Hospital Pharmacy 通年 薬学部 2018/04〜2019/03
統合型薬学演習 Integrated Pharmaceutical Exercise 後期 薬学部 2018/04〜2019/03
統合科学 Interdisciplinary Sciences 後期 全学共通科目 2018/04〜2019/03
臨床薬学概論 Introduction to Clinical Pharmacy 前期不定 薬学研究科 2018/04〜2019/03
臨床薬学総論 Introduction to Clinical Pharmacy 後期 薬学部 2018/04〜2019/03
「薬の世界」入門 Introduction to Pharmaceutical Sciences and Ethics 前期 全学共通科目 2018/04〜2019/03
薬剤学3(薬物動態学) Medicinal Pharmacy 3 (Biopharmaceutics) 後期 薬学部 2018/04〜2019/03
薬学実験技術 Basic Laboratory Techniques in Pharmaceutical Sciences 前期不定 薬学研究科 2018/04〜2019/03
薬学実験技術 Basic Laboratory Techniques in Pharmaceutical Sciences 後期不定 薬学研究科 2018/04〜2019/03
薬学研究実験Ⅲ Research in Pharmaceutical Sciences III 通年不定 薬学研究科 2018/04〜2019/03
薬学研究実験Ⅱ Research in Pharmaceutical Sciences II 後期前期 薬学研究科 2018/04〜2019/03
薬学研究実験Ⅱ Research in Pharmaceutical Sciences II 通年不定 薬学研究科 2018/04〜2019/03
薬学研究実験Ⅰ Research in Pharmaceutical Sciences I 後期前期 薬学研究科 2018/04〜2019/03
薬学研究実験Ⅰ Research in Pharmaceutical Sciences I 通年不定 薬学研究科 2018/04〜2019/03
薬学研究概論 Introduction to Pharmaceutical Sciences 前期不定 薬学研究科 2018/04〜2019/03
薬学研究演習Ⅲ Seminar for Pharmaceutical Sciences III 通年不定 薬学研究科 2018/04〜2019/03
薬学研究演習Ⅱ Seminar for Pharmaceutical Sciences II 後期前期 薬学研究科 2018/04〜2019/03
薬学研究演習Ⅱ Seminar for Pharmaceutical Sciences II 通年不定 薬学研究科 2018/04〜2019/03
薬学研究演習Ⅰ Seminar for Pharmaceutical Sciences I 後期前期 薬学研究科 2018/04〜2019/03
薬学研究演習Ⅰ Seminar for Pharmaceutical Sciences I 通年不定 薬学研究科 2018/04〜2019/03
薬学研究特論Ⅰ Advanced Pharmaceutical Sciences I 後期不定 薬学研究科 2018/04〜2019/03
薬局実務実習 Clinical Clerkship in Community Pharmacy 通年 薬学部 2018/04〜2019/03
薬物動態学 Biopharmaceutics 後期 工学研究科 2018/04〜2019/03
薬物動態学(LIMS) Biopharmaceutics (LIMS) 後期集中 医学研究科 2018/04〜2019/03

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全学運営(役職等)
役職名 期間
京都大学教務事務電算管理運営委員会 委員 2010/04/01〜2011/03/31
大学評価委員会 点検・評価実行委員会 委員 2010/04/01〜
教養教育専門委員会 委員 2008/04/01〜2011/03/31
教育研究評議会評議員 2010/04/01〜2012/03/31
京都大学教務事務電算管理運営委員会 委員 2011/04/01〜2012/03/31
大学評価委員会点検・評価実行委員会 委員 2011/04/01〜2012/03/31
教職教育委員会/教職科目連絡小委員会 委員 2011/04/01〜2012/03/31
評議員 2011/04/01〜2013/03/31
教職教育委員会 委員 2012/01/31〜2014/01/30
京都大学教職教育委員会教職科目連絡小委員会 委員 2012/04/01〜2013/03/31
大学評価委員会 点検・評価実行委員会 委員 2012/04/01〜2013/03/31
人権委員会 委員 2013/04/01〜2015/03/31
評議員 2010/04/01〜2014/03/31
京都大学財務委員会 委員 2014/04/01〜2014/09/30
全学情報セキュリティ委員会 委員 2014/04/01〜2016/03/31
博士課程教育リーディングプログラム運営会議 委員 2014/04/01〜2016/03/31
吉田寮整備委員会委員 2014/02/05〜2016/03/31
吉田寮業務実施委員会 委員 2014/04/01〜2016/03/31
国際高等教育院教養・共通教育協議会 委員 2014/04/01〜2016/03/31
大学評価委員会 委員 2014/04/01〜2016/03/31
教育研究評議会 評議員 2014/04/01〜2016/03/31
産官学連携本部運営協議会協議員 委員 2014/04/01〜2016/03/31
研究科長部会 2014/04/01〜2016/03/31
薬学研究科附属統合薬学教育開発センター長 2010/04/01〜2011/03/31
薬学研究科 研究科長 2014/04/01〜2016/03/31
薬学部 学部長 2014/04/01〜2016/03/31
薬用植物園長 2014/04/01〜2016/03/31
部局長会議 2014/04/01〜2016/03/31
薬学研究科附属統合薬学教育開発センター長 2014/04/01〜2016/03/31
薬学研究科 研究科長 2014/04/01〜2016/03/31
薬学部 学部長 2014/04/01〜2016/03/31
薬用植物園長 2014/04/01〜2016/03/31
研究科長部会 2014/04/01〜2016/03/31
部局長会議 2014/04/01〜2016/03/31
京都大学産学共同実用化促進事業実施委員会 3号委員 2014/04/01〜2015/09/09
産官学連携本部運営協議会 5号協議員 2014/04/01〜2016/03/31
原子力研究整備委員会 委員 2014/04/01〜
入学試験委員会 委員 2014/04/01〜2016/03/31
京都大学博士課程教育リーディングプログラム運営会議 委員 2014/04/01〜2016/03/31
京都大学研究公正の推進検討委員会 委員 2014/08/01〜2015/02/28
京都大学医学研究利益相反マネジメント委員会 2号委員 2014/09/01〜2016/08/31
京都大学研究公正の推進検討委員会 研究不正対応小委員会 委員長 2014/09/27〜2015/02/28
財務委員会 委員 2014/10/01〜2016/09/30
京都大学研究公正委員会 委員 2015/03/01〜
総長選考会議 委員 委員 2015/04/01〜2016/03/31
全学情報セキュリティ委員会 委員 2015/04/01〜
教育活動評価委員会 委員 2015/05/01〜2016/03/31
人事制度検討会 委員 2015/04/01〜2016/03/31
教員活動評価委員会 委員 2015/05/01〜2016/03/31
大学評価委員会 委員 2016/04/01〜
教育制度委員会 委員 2016/04/01〜2018/03/31
教育制度委員会WG1 委員 2016/04/01〜2017/03/31
原子力研究整備委員会 委員 2014/04/01〜2016/03/31
京都大学研究公正委員会 委員 2015/03/01〜2016/03/31
京都大学動物実験委員会 委員 2018/02/01〜2018/09/30
学生生活委員会 委員 2018/04/01〜2020/03/31
学生生活委員会第三小委員会 委員 2018/04/01〜2020/03/31
障害者入試委員会 委員 2018/04/01〜2019/03/31

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部局運営(役職等)
役職名 期間
教務委員長 2011/04/01〜2012/03/31
国際交流委員会 委員 2011/04/01〜2012/03/31
入試等問題検討委員会大学院小委員会 委員 2011/04/01〜2013/03/31
入試等問題検討委員会学部小委員会 委員 2011/04/01〜2012/03/31
将来計画委員会 委員 2011/04/01〜2014/03/31
エネルギー管理委員会 委員 2011/04/01〜2012/03/31
自己評価等調査検討委員会  2011/04/01〜
寄附講座検討委員会 委員 2011/04/01〜2014/03/31
寄附講座「医薬産業政策学講座」運営委員 2011/04/01〜
統合薬学教育開発センター運営委員会 委員 2011/04/01〜2014/03/31
実務実習委員会  2011/04/01〜2014/03/31
共用試験委員会  2011/04/01〜2014/03/31
安全環境委員長 2012/04/01〜2013/03/31
ハラスメント相談窓口 2012/04/01〜2014/03/31
将来計画委員会 委員長 2014/04/01〜2016/03/31
予算委員会 委員 2013/04/01〜
入試等問題検討委員会 委員 2013/04/01〜
元素分析研究施設・質量分析室運営委員会 委員 2014/04/01〜
超伝導NMRスペクトロメーター室運営管理委員会 委員 2014/04/01〜
エネルギー管理委員会 委員 2014/04/01〜
人権委員会 委員 2013/04/01〜
統合薬学教育開発センター運営委員会 委員長 2014/04/01〜2016/03/31
寄附講座検討委員会 委員長 2014/04/01〜2016/03/31
寄附講座「ナノバイオ医薬創成科学講座」運営委員 2014/04/01〜
兼業審査・利益相反審査委員会 委員長 2014/04/01〜2016/03/31
薬用植物園管理委員会 委員長 2014/04/01〜2016/03/31
国際交流委員会 委員 2014/04/01〜
学生便覧編集委員 2011/04/01〜2012/03/31
環境・安全衛生委員会 委員長 2012/04/01〜2014/03/31
教務委員会 副委員長 2012/04/01〜2014/03/31
薬学研究科薬学専攻長 2009/04/01〜2012/03/31
薬学研究科 薬学専攻長 2016/04/01〜2018/03/31
薬学科 学科長 2016/04/01〜2018/03/31
将来計画委員会 2016/04/01〜2020/03/31
実務実習委員会 委員長 2016/04/01〜2018/03/31
共用試験委員会 委員長 2016/04/01〜2018/03/31
入試等問題検討委員会委員長 2017/04/01〜2018/03/31
教務委員会委員 2016/04/01〜

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学会活動:学会役員歴
学会名(日本語) 学会名(英語) 役職名(日本語) 役職名(英語) 期間
日本DDS学会 評議員 1997/5〜
日本薬物動態学会 評議員 1998/10〜
日本薬剤学会 評議員 1998/5〜
日本DDS学会 幹事 2003/7〜2008/6
日本薬剤学会 理事 2007/5〜2011/4
日本DDS学会 常務理事 2008/7〜2012/6
日本DDS学会 副理事長 2012/7〜2015/7
日本薬剤学会 理事 2014/4〜2016/3
日本DDS学会 理事長 2015/7〜
日本薬学会 副会頭 2017/4〜
日本薬剤学会 理事 2018/7〜
日本核酸医薬学会 主幹事 2015/04/〜2018/03/

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学会活動:編集委員歴
学会名(日本語) 学会名(英語) ジャーナル名(日本語) ジャーナル名(英語) 役職名 期間
日本DDS学会 日本DDS学会機関誌 編集委員長 2010/7〜2015/7
Advanced Drug Delivery Reviews Editor 2006〜2011
European Journal of Pharmaceutical Sciences Editorial Board 2002〜
Drug Metabolism and Pharmacokinetics Editorial Board 2002〜
Journal of Biochemistry Editorial Advisory Board 2000〜
Pharmaceutical Research Editorial advisory board 2001〜
Biological and Pharmaceutical Bulletin Editorial Board 1999〜2003