川口 真也

最終更新日時: 2019/11/11 13:53:17

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氏名(漢字/フリガナ/アルファベット表記)
川口 真也/カワグチ シンヤ/Kawaguchi, Shinya
所属部署・職名(部局/所属/講座等/職名)
理学研究科/生物科学専攻高次情報形成学講座/教授
学部兼担
部局 所属 講座等 職名
理学部 助教
連絡先住所
種別 住所(日本語) 住所(英語)
職場 〒606-8502 京都市左京区北白川追分町 Oiwake, Kitashirakawa, Sakyo-ku, Kyoto, 606-8502
連絡先電話番号
種別 番号
職場 075-753-4200
全学電子メールアドレス
kawaguchi.shinya.7m @ kyoto-u.ac.jp
所属学会(国内)
学会名(日本語) 学会名(英語)
日本生理学会
日本神経科学会
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士(理学) 京都大学
博士(理学) 京都大学
職歴
期間 組織名(日本語) 組織名(英語) 職名(日本語) 職名(英語)
2004/04/03〜2007/03/31 京都大学大学院理学研究科  助手
2007/04/01〜2012/03/31 京都大学大学院理学研究科  助教
2012/04/01〜2017/03/31 同志社大学 特任准教授
2017/04/01〜 京都大学産官学連携本部 特定准教授
使用言語
言語名(japanese) 言語名(english) コード
英語
個人ホームページ
URL
http://www.nb.biophys.kyoto-u.ac.jp/main.html
ORCID ID
https://orcid.org/0000-0002-8386-1185
researchmap URL
https://researchmap.jp/shinyakawaguchi
研究テーマ
(日本語)
動物の脳神経系における記憶・学習を担う分子・細胞・神経回路メカニズムの研究
(英語)
Molecular, cellular, and neuronal circuit mechanisms for learning and memory
研究概要
(日本語)
動物が記憶・学習を実現する基礎現象と考えられているシナプス可塑性について、電気生理学や蛍光イメージングなどを用いて分子・細胞・神経回路レベルのメカニズムを研究している。
(英語)
I am studying a cellular basis of learning and memory, synaptic plasticity, at the level of molecular, cellular, and neuronal circuit using electrophysiology and fluorescent imaging techniques.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
神経科学一般 Neuroscience
シナプス synapse
神経生理 Neurophysiology
システム生物学 systems biology
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Shin-ya Kawaguchi Shin-ya Kawaguchi Shin-ya Kawaguchi Dynamic Factors for Transmitter Release at Small Presynaptic Boutons Revealed by Direct Patch-Clamp Recordings Dynamic Factors for Transmitter Release at Small Presynaptic Boutons Revealed by Direct Patch-Clamp Recordings Dynamic Factors for Transmitter Release at Small Presynaptic Boutons Revealed by Direct Patch-Clamp Recordings Frontiers in Cellular Neuroscience, 13, 269 Frontiers in Cellular Neuroscience, 13, 269 Frontiers in Cellular Neuroscience, 13, 269 2019/06 英語 研究論文(学術雑誌) 公開
Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, Wang DO Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, Wang DO Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, Wang DO Synaptic N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) epitranscriptome reveals functional partitioning of localized transcripts. Synaptic N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) epitranscriptome reveals functional partitioning of localized transcripts. Synaptic N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) epitranscriptome reveals functional partitioning of localized transcripts. Nature neuroscience Nature neuroscience Nature neuroscience 2018/06 公開
Yamashita M, Kawaguchi SY, Hori T, Takahashi T Yamashita M, Kawaguchi SY, Hori T, Takahashi T Yamashita M, Kawaguchi SY, Hori T, Takahashi T Vesicular GABA Uptake Can Be Rate Limiting for Recovery of IPSCs from Synaptic Depression. Vesicular GABA Uptake Can Be Rate Limiting for Recovery of IPSCs from Synaptic Depression. Vesicular GABA Uptake Can Be Rate Limiting for Recovery of IPSCs from Synaptic Depression. Cell reports, 22, 12, 3134-3141 Cell reports, 22, 12, 3134-3141 Cell reports, 22, 12, 3134-3141 2018/03 公開
Kawaguchi SY, Sakaba T Kawaguchi SY, Sakaba T Kawaguchi SY, Sakaba T Fast Ca<sup>2+</sup> Buffer-Dependent Reliable but Plastic Transmission at Small CNS Synapses Revealed by Direct Bouton Recording. Fast Ca<sup>2+</sup> Buffer-Dependent Reliable but Plastic Transmission at Small CNS Synapses Revealed by Direct Bouton Recording. Fast Ca<sup>2+</sup> Buffer-Dependent Reliable but Plastic Transmission at Small CNS Synapses Revealed by Direct Bouton Recording. Cell reports, 21, 12, 3338-3345 Cell reports, 21, 12, 3338-3345 Cell reports, 21, 12, 3338-3345 2017/12 公開
Zorrilla de San Martin J, Trigo FF, Kawaguchi SY Zorrilla de San Martin J, Trigo FF, Kawaguchi SY Zorrilla de San Martin J, Trigo FF, Kawaguchi SY Axonal GABA<sub>A</sub> receptors depolarize presynaptic terminals and facilitate transmitter release in cerebellar Purkinje cells. Axonal GABA<sub>A</sub> receptors depolarize presynaptic terminals and facilitate transmitter release in cerebellar Purkinje cells. Axonal GABA<sub>A</sub> receptors depolarize presynaptic terminals and facilitate transmitter release in cerebellar Purkinje cells. The Journal of physiology, 595, 24, 7477-7493 The Journal of physiology, 595, 24, 7477-7493 The Journal of physiology, 595, 24, 7477-7493 2017/12 公開
Díaz-Rojas F, Sakaba T, Kawaguchi SY Díaz-Rojas F, Sakaba T, Kawaguchi SY Díaz-Rojas F, Sakaba T, Kawaguchi SY Ca(2+) current facilitation determines short-term facilitation at inhibitory synapses between cerebellar Purkinje cells. Ca(2+) current facilitation determines short-term facilitation at inhibitory synapses between cerebellar Purkinje cells. Ca(2+) current facilitation determines short-term facilitation at inhibitory synapses between cerebellar Purkinje cells. The Journal of physiology, 593, 22, 4889-4904 The Journal of physiology, 593, 22, 4889-4904 The Journal of physiology, 593, 22, 4889-4904 2015/11 公開
Kawaguchi SY, Sakaba T Kawaguchi SY, Sakaba T Kawaguchi SY, Sakaba T Control of inhibitory synaptic outputs by low excitability of axon terminals revealed by direct recording. Control of inhibitory synaptic outputs by low excitability of axon terminals revealed by direct recording. Control of inhibitory synaptic outputs by low excitability of axon terminals revealed by direct recording. Neuron, 85, 6, 1273-1288 Neuron, 85, 6, 1273-1288 Neuron, 85, 6, 1273-1288 2015/03 公開
Nagasaki N, Hirano T, Kawaguchi SY Nagasaki N, Hirano T, Kawaguchi SY Nagasaki N, Hirano T, Kawaguchi SY Opposite regulation of inhibitory synaptic plasticity by α and β subunits of Ca(2+)/calmodulin-dependent protein kinase II. Opposite regulation of inhibitory synaptic plasticity by α and β subunits of Ca(2+)/calmodulin-dependent protein kinase II. Opposite regulation of inhibitory synaptic plasticity by α and β subunits of Ca(2+)/calmodulin-dependent protein kinase II. The Journal of physiology, 592, 22, 4891-4909 The Journal of physiology, 592, 22, 4891-4909 The Journal of physiology, 592, 22, 4891-4909 2014/11 公開
Hirano T, Kawaguchi SY Hirano T, Kawaguchi SY Hirano T, Kawaguchi SY Regulation and functional roles of rebound potentiation at cerebellar stellate cell-Purkinje cell synapses. Regulation and functional roles of rebound potentiation at cerebellar stellate cell-Purkinje cell synapses. Regulation and functional roles of rebound potentiation at cerebellar stellate cell-Purkinje cell synapses. Frontiers in cellular neuroscience, 8, 42 Frontiers in cellular neuroscience, 8, 42 Frontiers in cellular neuroscience, 8, 42 2014 公開
Tanaka S, Kawaguchi SY, Shioi G, Hirano T Tanaka S, Kawaguchi SY, Shioi G, Hirano T Tanaka S, Kawaguchi SY, Shioi G, Hirano T Long-term potentiation of inhibitory synaptic transmission onto cerebellar Purkinje neurons contributes to adaptation of vestibulo-ocular reflex. Long-term potentiation of inhibitory synaptic transmission onto cerebellar Purkinje neurons contributes to adaptation of vestibulo-ocular reflex. Long-term potentiation of inhibitory synaptic transmission onto cerebellar Purkinje neurons contributes to adaptation of vestibulo-ocular reflex. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 43, 17209-17220 The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 43, 17209-17220 The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 43, 17209-17220 2013/10 公開
Yamashita M, Kawaguchi SY, Hirano T Yamashita M, Kawaguchi SY, Hirano T Yamashita M, Kawaguchi SY, Hirano T Contribution of postsynaptic GluD2 to presynaptic R-type Ca(2+) channel function, glutamate release and long-term potentiation at parallel fiber to Purkinje cell synapses. Contribution of postsynaptic GluD2 to presynaptic R-type Ca(2+) channel function, glutamate release and long-term potentiation at parallel fiber to Purkinje cell synapses. Contribution of postsynaptic GluD2 to presynaptic R-type Ca(2+) channel function, glutamate release and long-term potentiation at parallel fiber to Purkinje cell synapses. Cerebellum (London, England), 12, 5, 657-666 Cerebellum (London, England), 12, 5, 657-666 Cerebellum (London, England), 12, 5, 657-666 2013/10 公開
Kawaguchi SY, Hirano T Kawaguchi SY, Hirano T Kawaguchi SY, Hirano T Gating of long-term depression by Ca2+/calmodulin-dependent protein kinase II through enhanced cGMP signalling in cerebellar Purkinje cells. Gating of long-term depression by Ca2+/calmodulin-dependent protein kinase II through enhanced cGMP signalling in cerebellar Purkinje cells. Gating of long-term depression by Ca2+/calmodulin-dependent protein kinase II through enhanced cGMP signalling in cerebellar Purkinje cells. The Journal of physiology, 591, 7, 1707-1730 The Journal of physiology, 591, 7, 1707-1730 The Journal of physiology, 591, 7, 1707-1730 2013/04 公開
Hirano T, Kawaguchi SY Hirano T, Kawaguchi SY Hirano T, Kawaguchi SY Regulation of inhibitory synaptic plasticity in a Purkinje neuron. Regulation of inhibitory synaptic plasticity in a Purkinje neuron. Regulation of inhibitory synaptic plasticity in a Purkinje neuron. Cerebellum (London, England), 11, 2, 453-454 Cerebellum (London, England), 11, 2, 453-454 Cerebellum (London, England), 11, 2, 453-454 2012/06 公開
Kawaguchi SY, Nagasaki N, Hirano T Kawaguchi SY, Nagasaki N, Hirano T Kawaguchi SY, Nagasaki N, Hirano T Dynamic impact of temporal context of Ca²⁺ signals on inhibitory synaptic plasticity. Dynamic impact of temporal context of Ca²⁺ signals on inhibitory synaptic plasticity. Dynamic impact of temporal context of Ca²⁺ signals on inhibitory synaptic plasticity. Scientific reports, 1, 143 Scientific reports, 1, 143 Scientific reports, 1, 143 2011 公開
Kitagawa Y, Hirano T, Kawaguchi SY Kitagawa Y, Hirano T, Kawaguchi SY Kitagawa Y, Hirano T, Kawaguchi SY Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity. Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity. Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity. Molecular systems biology, 5, 280 Molecular systems biology, 5, 280 Molecular systems biology, 5, 280 2009 公開
Tsuruno S, Kawaguchi SY, Hirano T Tsuruno S, Kawaguchi SY, Hirano T Tsuruno S, Kawaguchi SY, Hirano T Src-family protein tyrosine kinase negatively regulates cerebellar long-term depression. Src-family protein tyrosine kinase negatively regulates cerebellar long-term depression. Src-family protein tyrosine kinase negatively regulates cerebellar long-term depression. Neuroscience research, 61, 3, 329-332 Neuroscience research, 61, 3, 329-332 Neuroscience research, 61, 3, 329-332 2008/07 公開
Sugiyama Y, Kawaguchi SY, Hirano T Sugiyama Y, Kawaguchi SY, Hirano T Sugiyama Y, Kawaguchi SY, Hirano T mGluR1-mediated facilitation of long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron. mGluR1-mediated facilitation of long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron. mGluR1-mediated facilitation of long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron. The European journal of neuroscience, 27, 4, 884-896 The European journal of neuroscience, 27, 4, 884-896 The European journal of neuroscience, 27, 4, 884-896 2008/02 公開
Shima Y, Kawaguchi SY, Kosaka K, Nakayama M, Hoshino M, Nabeshima Y, Hirano T, Uemura T Shima Y, Kawaguchi SY, Kosaka K, Nakayama M, Hoshino M, Nabeshima Y, Hirano T, Uemura T Shima Y, Kawaguchi SY, Kosaka K, Nakayama M, Hoshino M, Nabeshima Y, Hirano T, Uemura T Opposing roles in neurite growth control by two seven-pass transmembrane cadherins. Opposing roles in neurite growth control by two seven-pass transmembrane cadherins. Opposing roles in neurite growth control by two seven-pass transmembrane cadherins. Nature neuroscience, 10, 8, 963-969 Nature neuroscience, 10, 8, 963-969 Nature neuroscience, 10, 8, 963-969 2007/08 公開
Kawaguchi SY, Hirano T Kawaguchi SY, Hirano T Kawaguchi SY, Hirano T Sustained structural change of GABA(A) receptor-associated protein underlies long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron. Sustained structural change of GABA(A) receptor-associated protein underlies long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron. Sustained structural change of GABA(A) receptor-associated protein underlies long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27, 25, 6788-6799 The Journal of neuroscience : the official journal of the Society for Neuroscience, 27, 25, 6788-6799 The Journal of neuroscience : the official journal of the Society for Neuroscience, 27, 25, 6788-6799 2007/06 公開
Kawaguchi SY, Hirano T Kawaguchi SY, Hirano T Kawaguchi SY, Hirano T Integrin alpha3beta1 suppresses long-term potentiation at inhibitory synapses on the cerebellar Purkinje neuron. Integrin alpha3beta1 suppresses long-term potentiation at inhibitory synapses on the cerebellar Purkinje neuron. Integrin alpha3beta1 suppresses long-term potentiation at inhibitory synapses on the cerebellar Purkinje neuron. Molecular and cellular neurosciences, 31, 3, 416-426 Molecular and cellular neurosciences, 31, 3, 416-426 Molecular and cellular neurosciences, 31, 3, 416-426 2006/03 公開
Tohgo A, Eiraku M, Miyazaki T, Miura E, Kawaguchi SY, Nishi M, Watanabe M, Hirano T, Kengaku M, Takeshima H Tohgo A, Eiraku M, Miyazaki T, Miura E, Kawaguchi SY, Nishi M, Watanabe M, Hirano T, Kengaku M, Takeshima H Tohgo A, Eiraku M, Miyazaki T, Miura E, Kawaguchi SY, Nishi M, Watanabe M, Hirano T, Kengaku M, Takeshima H Impaired cerebellar functions in mutant mice lacking DNER. Impaired cerebellar functions in mutant mice lacking DNER. Impaired cerebellar functions in mutant mice lacking DNER. Molecular and cellular neurosciences, 31, 2, 326-333 Molecular and cellular neurosciences, 31, 2, 326-333 Molecular and cellular neurosciences, 31, 2, 326-333 2006/02 公開
Ohtsuki G, Kawaguchi SY, Mishina M, Hirano T Ohtsuki G, Kawaguchi SY, Mishina M, Hirano T Ohtsuki G, Kawaguchi SY, Mishina M, Hirano T Enhanced inhibitory synaptic transmission in the cerebellar molecular layer of the GluRdelta2 knock-out mouse. Enhanced inhibitory synaptic transmission in the cerebellar molecular layer of the GluRdelta2 knock-out mouse. Enhanced inhibitory synaptic transmission in the cerebellar molecular layer of the GluRdelta2 knock-out mouse. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24, 48, 10900-10907 The Journal of neuroscience : the official journal of the Society for Neuroscience, 24, 48, 10900-10907 The Journal of neuroscience : the official journal of the Society for Neuroscience, 24, 48, 10900-10907 2004/12 公開
Hirano T, Watanabe D, Kawaguchi SY, Pastan I, Nakanishi S Hirano T, Watanabe D, Kawaguchi SY, Pastan I, Nakanishi S Hirano T, Watanabe D, Kawaguchi SY, Pastan I, Nakanishi S Roles of inhibitory interneurons in the cerebellar cortex. Roles of inhibitory interneurons in the cerebellar cortex. Roles of inhibitory interneurons in the cerebellar cortex. Annals of the New York Academy of Sciences, 978, 405-412 Annals of the New York Academy of Sciences, 978, 405-412 Annals of the New York Academy of Sciences, 978, 405-412 2002/12 公開
Kawaguchi SY, Hirano T Kawaguchi SY, Hirano T Kawaguchi SY, Hirano T Signaling cascade regulating long-term potentiation of GABA(A) receptor responsiveness in cerebellar Purkinje neurons. Signaling cascade regulating long-term potentiation of GABA(A) receptor responsiveness in cerebellar Purkinje neurons. Signaling cascade regulating long-term potentiation of GABA(A) receptor responsiveness in cerebellar Purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22, 10, 3969-3976 The Journal of neuroscience : the official journal of the Society for Neuroscience, 22, 10, 3969-3976 The Journal of neuroscience : the official journal of the Society for Neuroscience, 22, 10, 3969-3976 2002/05 公開
Kawaguchi S, Hirano T Kawaguchi S, Hirano T Kawaguchi S, Hirano T Suppression of inhibitory synaptic potentiation by presynaptic activity through postsynaptic GABA(B) receptors in a Purkinje neuron. Suppression of inhibitory synaptic potentiation by presynaptic activity through postsynaptic GABA(B) receptors in a Purkinje neuron. Suppression of inhibitory synaptic potentiation by presynaptic activity through postsynaptic GABA(B) receptors in a Purkinje neuron. Neuron, 27, 2, 339-347 Neuron, 27, 2, 339-347 Neuron, 27, 2, 339-347 2000/08 公開

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タイトル言語:
Misc
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
川口真也, 平野丈夫 川口真也, 平野丈夫 川口真也, 平野丈夫 GABAB受容体による小脳抑制性シナプス可塑性の制御 (特集 Gタンパク質共役受容体と脳機能) GABAB受容体による小脳抑制性シナプス可塑性の制御 (特集 Gタンパク質共役受容体と脳機能) GABAB受容体による小脳抑制性シナプス可塑性の制御 (特集 Gタンパク質共役受容体と脳機能) 遺伝子医学, 7, 2, 195-198 遺伝子医学, 7, 2, 195-198 遺伝子医学, 7, 2, 195-198 2003/06 公開
タイトル言語:
外部資金:競争的資金 (科学研究費補助金)
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
特定領域研究 代表 インテグリンによるシナプス伝達安的化機構の解析 Mechanism to stabilize synaptic transmission by integrins 2005〜2005
若手研究 (B) 代表 抑制性シナプス可塑性におけるGABA(A)受容体の変化 Change of GABA(A) receptors in inhibitory synaptic plasticity 2006〜2007
若手研究(B) 代表 抑制性シナプス可塑性の長期持続の分子機構 2009〜2010
若手研究 (B) 代表 シナプス前・後部の機能変化を担うシグナル動態の可視化 2013/04/01〜2015/03/31
基盤 (C) 代表 神経軸索における動的情報処理 2015/04/01〜2018/03/31
基盤 (B) 特設分野 代表 学習する培養神経回路の構成とそのシステム解析 2015/07/01〜
新学術領域研究 代表 記憶の成立と移動をになう小脳神経回路の機能変化 2016/04/01〜2018/03/31
基盤 (B) 代表 記憶をつくるシナプス・細胞集団の光技術による可視化と動態解析 2018/04/01〜
基盤研究(B) 代表 学習する培養神経回路の構成とそのシステム解析 (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(C) 代表 神経軸索における動的情報処理 (平成29年度分) 2017/04/01〜2018/03/31
新学術領域研究(研究領域提案型) 代表 記憶の成立と移動をになう小脳神経回路の機能変化 (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(B) 代表 学習する培養神経回路の構成とそのシステム解析 (平成30年度分) 2018/04/01〜2019/03/31
基盤研究(B) 代表 記憶をつくるシナプス・細胞集団の光技術による可視化と動態解析 (平成30年度分) 2018/04/01〜2019/03/31

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外部資金:競争的資金 (科学研究費補助金以外)
制度名 代表者名 研究課題(日本語) 研究課題(英語) 期間
二国間交流事業共同研究・セミナー 川口 真也 小脳プルキンエ細胞における軸索での伝達物質受容体による情報伝達制御 (平成29年度分) 2017/04/01〜2018/03/31
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
生物学実習D (4) 後期 理学部 2011/04〜
生物学セミナ-A (10) 後期 理学部 2011/04〜
生物科学課題研究19 通年 理学部 2011/04〜