樋口 ゆり子

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氏名(漢字/フリガナ/アルファベット表記)
樋口 ゆり子/ヒグチ ユリコ/Yuriko Higuchi
所属部署・職名(部局/所属/講座等/職名)
薬学研究科/薬学専攻薬品動態医療薬学講座/講師
学部兼担
部局 所属 講座等 職名
薬学部
連絡先住所
種別 住所(日本語) 住所(英語)
職場 京都大学大学院薬学研究科 薬品動態制御学分野
連絡先電話番号
種別 番号
職場
所属学会(国内)
学会名(日本語) 学会名(英語)
日本薬学会
日本DDS学会
日本薬剤学会
日本薬物動態学会
日本バイオイメージング学会
日本分子イメージング学会
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士(薬学) 京都大学
博士(薬学) 京都大学
出身大学院・研究科等
大学名(日本語) 大学名(英語) 研究科名(日本語) 研究科名(英語) 専攻名(日本語) 専攻名(英語) 修了区分
京都大学 大学院薬学研究科修士課程医療薬科学専攻 修了
京都大学 大学院薬学研究科博士後期課程医療薬科学専攻 修了
職歴
期間 組織名(日本語) 組織名(英語) 職名(日本語) 職名(英語)
2005/04/01〜2009/03/31 京都大学大学院薬学研究科 博士研究員
2009/04/01〜2013/03/15 京都大学大学院薬学研究科 特定助教
2009/10/01〜2013/03/31 科学技術振興機構 戦略的創造研究推進事業 さきがけ研究員(兼任)
2013/03/16〜2016/04/30 京都大学学際融合教育研究推進センター 特定講師
2016/05/01〜 京都大学大学院薬学研究科 講師
ORCID ID
orcid.org/https://orcid.org/0000-0002-9869-1019
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Abdalkader R, Kawakami S, Unga J, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M Abdalkader R, Kawakami S, Unga J, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M Abdalkader R, Kawakami S, Unga J, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M The development of mechanically formed stable nanobubbles intended for sonoporation-mediated gene transfection. The development of mechanically formed stable nanobubbles intended for sonoporation-mediated gene transfection. The development of mechanically formed stable nanobubbles intended for sonoporation-mediated gene transfection. Drug delivery, 24, 1, 320-327 Drug delivery, 24, 1, 320-327 Drug delivery, 24, 1, 320-327 2017/11 公開
Yamashita F, Fujita A, Sasa Y, Higuchi Y, Tsuda M, Hashida M Yamashita F, Fujita A, Sasa Y, Higuchi Y, Tsuda M, Hashida M Yamashita F, Fujita A, Sasa Y, Higuchi Y, Tsuda M, Hashida M An Evolutionary Search Algorithm for Covariate Models in Population Pharmacokinetic Analysis. An Evolutionary Search Algorithm for Covariate Models in Population Pharmacokinetic Analysis. An Evolutionary Search Algorithm for Covariate Models in Population Pharmacokinetic Analysis. Journal of pharmaceutical sciences, 106, 9, 2407-2411 Journal of pharmaceutical sciences, 106, 9, 2407-2411 Journal of pharmaceutical sciences, 106, 9, 2407-2411 2017/09 公開
Chantarasrivong C, Ueki A, Ohyama R, Unga J, Nakamura S, Nakanishi I, Higuchi Y, Kawakami S, Ando H, Imamura A, Ishida H, Yamashita F, Kiso M, Hashida M Chantarasrivong C, Ueki A, Ohyama R, Unga J, Nakamura S, Nakanishi I, Higuchi Y, Kawakami S, Ando H, Imamura A, Ishida H, Yamashita F, Kiso M, Hashida M Chantarasrivong C, Ueki A, Ohyama R, Unga J, Nakamura S, Nakanishi I, Higuchi Y, Kawakami S, Ando H, Imamura A, Ishida H, Yamashita F, Kiso M, Hashida M Synthesis and Functional Characterization of Novel Sialyl LewisX Mimic-Decorated Liposomes for E-selectin-Mediated Targeting to Inflamed Endothelial Cells. Synthesis and Functional Characterization of Novel Sialyl LewisX Mimic-Decorated Liposomes for E-selectin-Mediated Targeting to Inflamed Endothelial Cells. Synthesis and Functional Characterization of Novel Sialyl LewisX Mimic-Decorated Liposomes for E-selectin-Mediated Targeting to Inflamed Endothelial Cells. Molecular pharmaceutics, 14, 5, 1528-1537 Molecular pharmaceutics, 14, 5, 1528-1537 Molecular pharmaceutics, 14, 5, 1528-1537 2017/05 公開
Ohta T, Hashida Y, Higuchi Y, Yamashita F, Hashida M Ohta T, Hashida Y, Higuchi Y, Yamashita F, Hashida M Ohta T, Hashida Y, Higuchi Y, Yamashita F, Hashida M In Vitro Cellular Gene Delivery Employing a Novel Composite Material of Single-Walled Carbon Nanotubes Associated With Designed Peptides With Pegylation. In Vitro Cellular Gene Delivery Employing a Novel Composite Material of Single-Walled Carbon Nanotubes Associated With Designed Peptides With Pegylation. In Vitro Cellular Gene Delivery Employing a Novel Composite Material of Single-Walled Carbon Nanotubes Associated With Designed Peptides With Pegylation. Journal of pharmaceutical sciences, 106, 3, 792-802 Journal of pharmaceutical sciences, 106, 3, 792-802 Journal of pharmaceutical sciences, 106, 3, 792-802 2017/03 公開
Hatanaka W, Kawaguchi M, Sun X, Nagao Y, Ohshima H, Hashida M, Higuchi Y, Kishimura A, Katayama Y, Mori T Hatanaka W, Kawaguchi M, Sun X, Nagao Y, Ohshima H, Hashida M, Higuchi Y, Kishimura A, Katayama Y, Mori T Hatanaka W, Kawaguchi M, Sun X, Nagao Y, Ohshima H, Hashida M, Higuchi Y, Kishimura A, Katayama Y, Mori T Use of Membrane Potential to Achieve Transmembrane Modification with an Artificial Receptor. Use of Membrane Potential to Achieve Transmembrane Modification with an Artificial Receptor. Use of Membrane Potential to Achieve Transmembrane Modification with an Artificial Receptor. Bioconjugate chemistry, 28, 2, 296-301 Bioconjugate chemistry, 28, 2, 296-301 Bioconjugate chemistry, 28, 2, 296-301 2017/02 公開
Yanamoto S, Babazada H, Sakai S, Higuchi Y, Yamashita F, Hashida M Yanamoto S, Babazada H, Sakai S, Higuchi Y, Yamashita F, Hashida M Yanamoto S, Babazada H, Sakai S, Higuchi Y, Yamashita F, Hashida M Anti-inflammatory Effect of Self-assembling Glycol-Split Glycosaminoglycan-Stearylamine Conjugates in Lipopolysaccharide-Stimulated Macrophages. Anti-inflammatory Effect of Self-assembling Glycol-Split Glycosaminoglycan-Stearylamine Conjugates in Lipopolysaccharide-Stimulated Macrophages. Anti-inflammatory Effect of Self-assembling Glycol-Split Glycosaminoglycan-Stearylamine Conjugates in Lipopolysaccharide-Stimulated Macrophages. Biological & pharmaceutical bulletin, 40, 4, 540-545 Biological & pharmaceutical bulletin, 40, 4, 540-545 Biological & pharmaceutical bulletin, 40, 4, 540-545 2017 公開
Oda Y, Suzuki R, Mori T, Takahashi H, Natsugari H, Omata D, Unga J, Uruga H, Sugii M, Kawakami S, Higuchi Y, Yamashita F, Hashida M, Maruyama K Oda Y, Suzuki R, Mori T, Takahashi H, Natsugari H, Omata D, Unga J, Uruga H, Sugii M, Kawakami S, Higuchi Y, Yamashita F, Hashida M, Maruyama K Oda Y, Suzuki R, Mori T, Takahashi H, Natsugari H, Omata D, Unga J, Uruga H, Sugii M, Kawakami S, Higuchi Y, Yamashita F, Hashida M, Maruyama K Development of fluorous lipid-based nanobubbles for efficiently containing perfluoropropane. Development of fluorous lipid-based nanobubbles for efficiently containing perfluoropropane. Development of fluorous lipid-based nanobubbles for efficiently containing perfluoropropane. International journal of pharmaceutics, 487, 1-2, 64-71 International journal of pharmaceutics, 487, 1-2, 64-71 International journal of pharmaceutics, 487, 1-2, 64-71 2015/06 公開
Cabral H, Makino J, Matsumoto Y, Mi P, Wu H, Nomoto T, Toh K, Yamada N, Higuchi Y, Konishi S, Kano MR, Nishihara H, Miura Y, Nishiyama N, Kataoka K Cabral H, Makino J, Matsumoto Y, Mi P, Wu H, Nomoto T, Toh K, Yamada N, Higuchi Y, Konishi S, Kano MR, Nishihara H, Miura Y, Nishiyama N, Kataoka K Cabral H, Makino J, Matsumoto Y, Mi P, Wu H, Nomoto T, Toh K, Yamada N, Higuchi Y, Konishi S, Kano MR, Nishihara H, Miura Y, Nishiyama N, Kataoka K Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers. Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers. Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers. ACS nano, 9, 5, 4957-4967 ACS nano, 9, 5, 4957-4967 ACS nano, 9, 5, 4957-4967 2015/05 公開
Yoshida M, Kawakami S, Kono Y, Un K, Higuchi Y, Maruyama K, Yamashita F, Hashida M Yoshida M, Kawakami S, Kono Y, Un K, Higuchi Y, Maruyama K, Yamashita F, Hashida M Yoshida M, Kawakami S, Kono Y, Un K, Higuchi Y, Maruyama K, Yamashita F, Hashida M Enhancement of the anti-tumor effect of DNA vaccination using an ultrasound-responsive mannose-modified gene carrier in combination with doxorubicin-encapsulated PEGylated liposomes. Enhancement of the anti-tumor effect of DNA vaccination using an ultrasound-responsive mannose-modified gene carrier in combination with doxorubicin-encapsulated PEGylated liposomes. Enhancement of the anti-tumor effect of DNA vaccination using an ultrasound-responsive mannose-modified gene carrier in combination with doxorubicin-encapsulated PEGylated liposomes. International journal of pharmaceutics, 475, 1-2, 401-407 International journal of pharmaceutics, 475, 1-2, 401-407 International journal of pharmaceutics, 475, 1-2, 401-407 2014/11 公開
Kurosaki T, Kawakami S, Higuchi Y, Suzuki R, Maruyama K, Sasaki H, Yamashita F, Hashida M Kurosaki T, Kawakami S, Higuchi Y, Suzuki R, Maruyama K, Sasaki H, Yamashita F, Hashida M Kurosaki T, Kawakami S, Higuchi Y, Suzuki R, Maruyama K, Sasaki H, Yamashita F, Hashida M Kidney-selective gene transfection using anionic bubble lipopolyplexes with renal ultrasound irradiation in mice. Kidney-selective gene transfection using anionic bubble lipopolyplexes with renal ultrasound irradiation in mice. Kidney-selective gene transfection using anionic bubble lipopolyplexes with renal ultrasound irradiation in mice. Nanomedicine : nanotechnology, biology, and medicine, 10, 8, 1829-1838 Nanomedicine : nanotechnology, biology, and medicine, 10, 8, 1829-1838 Nanomedicine : nanotechnology, biology, and medicine, 10, 8, 1829-1838 2014/11 公開
Nakanishi H, Higuchi Y, Yamashita F, Hashida M Nakanishi H, Higuchi Y, Yamashita F, Hashida M Nakanishi H, Higuchi Y, Yamashita F, Hashida M Targeted gene integration using the combination of a sequence-specific DNA-binding protein and phiC31 integrase. Targeted gene integration using the combination of a sequence-specific DNA-binding protein and phiC31 integrase. Targeted gene integration using the combination of a sequence-specific DNA-binding protein and phiC31 integrase. Journal of biotechnology, 186, 139-147 Journal of biotechnology, 186, 139-147 Journal of biotechnology, 186, 139-147 2014/09 公開
Yoshida M, Kawakami S, Un K, Kono Y, Higuchi Y, Yamashita F, Hashida M Yoshida M, Kawakami S, Un K, Kono Y, Higuchi Y, Yamashita F, Hashida M Yoshida M, Kawakami S, Un K, Kono Y, Higuchi Y, Yamashita F, Hashida M Evaluation of inflammatory responses due to small interfering RNA transfer using unmodified- and mannose-modified bubble lipoplexes with ultrasound exposure in primary cultured macrophages. Evaluation of inflammatory responses due to small interfering RNA transfer using unmodified- and mannose-modified bubble lipoplexes with ultrasound exposure in primary cultured macrophages. Evaluation of inflammatory responses due to small interfering RNA transfer using unmodified- and mannose-modified bubble lipoplexes with ultrasound exposure in primary cultured macrophages. Journal of drug targeting, 22, 8, 732-738 Journal of drug targeting, 22, 8, 732-738 Journal of drug targeting, 22, 8, 732-738 2014/09 公開
Kono Y, Kawakami S, Higuchi Y, Maruyama K, Yamashita F, Hashida M Kono Y, Kawakami S, Higuchi Y, Maruyama K, Yamashita F, Hashida M Kono Y, Kawakami S, Higuchi Y, Maruyama K, Yamashita F, Hashida M Antitumor effect of nuclear factor-κB decoy transfer by mannose-modified bubble lipoplex into macrophages in mouse malignant ascites. Antitumor effect of nuclear factor-κB decoy transfer by mannose-modified bubble lipoplex into macrophages in mouse malignant ascites. Antitumor effect of nuclear factor-κB decoy transfer by mannose-modified bubble lipoplex into macrophages in mouse malignant ascites. Cancer science, 105, 8, 1049-1055 Cancer science, 105, 8, 1049-1055 Cancer science, 105, 8, 1049-1055 2014/08 公開
Ukawa M, Akita H, Hayashi Y, Ishiba R, Tange K, Arai M, Kubo K, Higuchi Y, Shimizu K, Konishi S, Hashida M, Harashima H Ukawa M, Akita H, Hayashi Y, Ishiba R, Tange K, Arai M, Kubo K, Higuchi Y, Shimizu K, Konishi S, Hashida M, Harashima H M. Ukawa; H. Akita; Y. Hayashi; R. Ishiba; K. Tange; M. Arai; K. Kubo; Y. Higuchi; K. Shimizu; S. Konishi; M. Hashida; H. Harashima Neutralized nanoparticle composed of SS-cleavable and pH-activated lipid-like material as a long-lasting and liver-specific gene delivery system. Neutralized nanoparticle composed of SS-cleavable and pH-activated lipid-like material as a long-lasting and liver-specific gene delivery system. Neutralized nanoparticle composed of ss-cleavable and ph-activated lipid-like material as a long-lasting and liver-specific gene delivery system Advanced healthcare materials, 3, 8, 1222-1229 Advanced healthcare materials, 3, 8, 1222-1229 Advanced Healthcare Materials, 3, 8, 1222-1229 2014/08 英語 公開
Kono Y, Kawakami S, Higuchi Y, Maruyama K, Yamashita F, Hashida M Kono Y, Kawakami S, Higuchi Y, Maruyama K, Yamashita F, Hashida M Kono Y, Kawakami S, Higuchi Y, Maruyama K, Yamashita F, Hashida M Tumour-associated macrophages targeted transfection with NF-κB decoy/mannose-modified bubble lipoplexes inhibits tumour growth in tumour-bearing mice. Tumour-associated macrophages targeted transfection with NF-κB decoy/mannose-modified bubble lipoplexes inhibits tumour growth in tumour-bearing mice. Tumour-associated macrophages targeted transfection with NF-κB decoy/mannose-modified bubble lipoplexes inhibits tumour growth in tumour-bearing mice. Journal of drug targeting, 22, 5, 439-449 Journal of drug targeting, 22, 5, 439-449 Journal of drug targeting, 22, 5, 439-449 2014/06 公開
Kurosaki T, Kawakami S, Higuchi Y, Suzuki R, Maruyama K, Sasaki H, Yamashita F, Hashida M Kurosaki T, Kawakami S, Higuchi Y, Suzuki R, Maruyama K, Sasaki H, Yamashita F, Hashida M T. Kurosaki; S. Kawakami; Y. Higuchi; R. Suzuki; K. Maruyama; H. Sasaki; F. Yamashita; M. Hashida Development of anionic bubble lipopolyplexes for efficient and safe gene transfection with ultrasound exposure in mice. Development of anionic bubble lipopolyplexes for efficient and safe gene transfection with ultrasound exposure in mice. Development of anionic bubble lipopolyplexes for efficient and safe gene transfection with ultrasound exposure in mice Journal of controlled release : official journal of the Controlled Release Society, 176, 24-34 Journal of controlled release : official journal of the Controlled Release Society, 176, 24-34 Journal of Controlled Release, 176, 24-34 2014/02 英語 公開
Kono Y, Kawakami S, Higuchi Y, Yamashita F, Hashida M Kono Y, Kawakami S, Higuchi Y, Yamashita F, Hashida M Y. Kono; S. Kawakami; Y. Higuchi; F. Yamashita; M. Hashida In vitro evaluation of inhibitory effect of nuclear factor-kappaB activity by small interfering RNA on pro-tumor characteristics of M2-like macrophages. In vitro evaluation of inhibitory effect of nuclear factor-kappaB activity by small interfering RNA on pro-tumor characteristics of M2-like macrophages. In vitro evaluation of inhibitory effect of nuclear factor-kappab activity by small interfering RNA on pro-tumor characteristics of m2-like macrophages Biological & pharmaceutical bulletin, 37, 1, 137-144 Biological & pharmaceutical bulletin, 37, 1, 137-144 Biological and Pharmaceutical Bulletin, 37, 1, 137-144 2014/01 英語 公開
Takafuji Y, Higuchi Y, Muro A, Oshiro K, Kawakami S, Yamashita F, Hashida M Takafuji Y, Higuchi Y, Muro A, Oshiro K, Kawakami S, Yamashita F, Hashida M Y. Takafuji; Y. Higuchi; A. Muro; K. Oshiro; S. Kawakami; F. Yamashita; M. Hashida Factors influencing the surface modification of mesenchymal stem cells with fluorescein-pegylated lipids. Factors influencing the surface modification of mesenchymal stem cells with fluorescein-pegylated lipids. Factors influencing the surface modification of mesenchymal stem cells with fluorescein-pegylated lipids Biological & pharmaceutical bulletin, 36, 11, 1731-1738 Biological & pharmaceutical bulletin, 36, 11, 1731-1738 Biological and Pharmaceutical Bulletin, 36, 11, 1731-1738 2013 英語 公開
Umemoto Y, Kawakami S, Otani Y, Higuchi Y, Yamashita F, Hashida M Umemoto Y, Kawakami S, Otani Y, Higuchi Y, Yamashita F, Hashida M Y. Umemoto; S. Kawakami; Y. Otani; Y. Higuchi; F. Yamashita; M. Hashida Evaluation of long-term gene expression in mouse liver using PhiC31 integrase and hydrodynamic injection. Evaluation of long-term gene expression in mouse liver using PhiC31 integrase and hydrodynamic injection. Evaluation of long-term gene expression in mouse liver using PhiC31 integrase and hydrodynamic injection Biological & pharmaceutical bulletin, 35, 7, 1182-1186 Biological & pharmaceutical bulletin, 35, 7, 1182-1186 Biological and Pharmaceutical Bulletin, 35, 7, 1182-1186 2012/07 英語 公開
Tsukamoto M, Okuda T, Okamoto H, Higuchi Y, Kawakami S, Yamashita F, Hashida M Tsukamoto M, Okuda T, Okamoto H, Higuchi Y, Kawakami S, Yamashita F, Hashida M M. Tsukamoto; T. Okuda; H. Okamoto; Y. Higuchi; S. Kawakami; F. Yamashita; M. Hashida Bovine serum albumin as a lyoprotectant for preparation of DNA dry powder formulations using the spray-freeze drying method. Bovine serum albumin as a lyoprotectant for preparation of DNA dry powder formulations using the spray-freeze drying method. Bovine serum albumin as a lyoprotectant for preparation of DNA dry powder formulations using the spray-freeze drying method Biological & pharmaceutical bulletin, 35, 7, 1178-1181 Biological & pharmaceutical bulletin, 35, 7, 1178-1181 Biological and Pharmaceutical Bulletin, 35, 7, 1178-1181 2012/07 英語 公開
Un K, Kawakami S, Yoshida M, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M Un K, Kawakami S, Yoshida M, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M K. Un; S. Kawakami; M. Yoshida; Y. Higuchi; R. Suzuki; K. Maruyama; F. Yamashita; M. Hashida Efficient suppression of murine intracellular adhesion molecule-1 using ultrasound-responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation. Efficient suppression of murine intracellular adhesion molecule-1 using ultrasound-responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation. Efficient suppression of murine intracellular adhesion molecule-1 using ultrasound-responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation Hepatology (Baltimore, Md.), 56, 1, 259-269 Hepatology (Baltimore, Md.), 56, 1, 259-269 Hepatology, 56, 1, 259-269 2012/07 英語 公開
Y. Higuchi Y. Higuchi Higuchi Y Development of fluorescent labeling methods for stem cells Development of fluorescent labeling methods for stem cells [Development of fluorescent labeling methods for stem cells]. Yakugaku Zasshi, 132, 4, 433-439 Yakugaku Zasshi, 132, 4, 433-439 Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 132, 4, 433-439 2012/04 日本語 公開
Kurosaki T, Higuchi N, Kawakami S, Higuchi Y, Nakamura T, Kitahara T, Hashida M, Sasaki H Kurosaki T, Higuchi N, Kawakami S, Higuchi Y, Nakamura T, Kitahara T, Hashida M, Sasaki H T. Kurosaki; N. Higuchi; S. Kawakami; Y. Higuchi; T. Nakamura; T. Kitahara; M. Hashida; H. Sasaki Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer. Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer. Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer Gene, 491, 2, 205-209 Gene, 491, 2, 205-209 Gene, 491, 2, 205-209 2012/01/10 英語 公開
Zhou S, Kawakami S, Higuchi Y, Yamashita F, Hashida M Zhou S, Kawakami S, Higuchi Y, Yamashita F, Hashida M S. Zhou; S. Kawakami; Y. Higuchi; F. Yamashita; M. Hashida The involvement of NK cell activation following intranasal administration of CpG DNA lipoplex in the prevention of pulmonary metastasis and peritoneal dissemination in mice. The involvement of NK cell activation following intranasal administration of CpG DNA lipoplex in the prevention of pulmonary metastasis and peritoneal dissemination in mice. The involvement of NK cell activation following intranasal administration of CpG DNA lipoplex in the prevention of pulmonary metastasis and peritoneal dissemination in mice Clinical & experimental metastasis, 29, 1, 63-70 Clinical & experimental metastasis, 29, 1, 63-70 Clinical and Experimental Metastasis, 29, 1, 63-70 2012/01 英語 公開
Saito K, Chang YF, Horikawa K, Hatsugai N, Higuchi Y, Hashida M, Yoshida Y, Matsuda T, Arai Y, Nagai T Saito K, Chang YF, Horikawa K, Hatsugai N, Higuchi Y, Hashida M, Yoshida Y, Matsuda T, Arai Y, Nagai T K. Saito; Y.-F. Chang; K. Horikawa; N. Hatsugai; Y. Higuchi; M. Hashida; Y. Yoshida; T. Matsuda; Y. Arai; T. Nagai Luminescent proteins for high-speed single-cell and whole-body imaging. Luminescent proteins for high-speed single-cell and whole-body imaging. Luminescent proteins for high-speed single-cell and whole-body imaging Nature communications, 3, 1262 Nature communications, 3, 1262 Nature Communications, 3, 1262 2012 英語 公開
Higuchi Y, Akita H Higuchi Y, Akita H Y. Higuchi; H. Akita [Photonics meets sensing of bio-reaction and cell dynamics]. [Photonics meets sensing of bio-reaction and cell dynamics]. Photonics meets sensing of bio-reaction and cell dynamics Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 132, 4, 395 Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 132, 4, 395 Yakugaku Zasshi, 132, 4, 395 2012 英語 公開
Chang KL, Higuchi Y, Kawakami S, Yamashita F, Hashida M Chang KL, Higuchi Y, Kawakami S, Yamashita F, Hashida M K.-L. Chang; Y. Higuchi; S. Kawakami; F. Yamashita; M. Hashida Development of lysine-histidine dendron modified chitosan for improving transfection efficiency in HEK293 cells. Development of lysine-histidine dendron modified chitosan for improving transfection efficiency in HEK293 cells. Development of lysine-histidine dendron modified chitosan for improving transfection efficiency in HEK293 cells Journal of controlled release : official journal of the Controlled Release Society, 156, 2, 195-202 Journal of controlled release : official journal of the Controlled Release Society, 156, 2, 195-202 Journal of Controlled Release, 156, 2, 195-202 2011/12 英語 公開
Un K, Kawakami S, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M Un K, Kawakami S, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M K. Un; S. Kawakami; Y. Higuchi; R. Suzuki; K. Maruyama; F. Yamashita; M. Hashida Involvement of activated transcriptional process in efficient gene transfection using unmodified and mannose-modified bubble lipoplexes with ultrasound exposure. Involvement of activated transcriptional process in efficient gene transfection using unmodified and mannose-modified bubble lipoplexes with ultrasound exposure. Involvement of activated transcriptional process in efficient gene transfection using unmodified and mannose-modified bubble lipoplexes with ultrasound exposure Journal of controlled release : official journal of the Controlled Release Society, 156, 3, 355-363 Journal of controlled release : official journal of the Controlled Release Society, 156, 3, 355-363 Journal of Controlled Release, 156, 3, 355-363 2011/12 英語 公開
Shimizu K, Higuchi Y, Kozu Y, Hashida M, Konishi S Shimizu K, Higuchi Y, Kozu Y, Hashida M, Konishi S K. Shimizu; Y. Higuchi; Y. Kozu; M. Hashida; S. Konishi Development of a suction device for stabilizing in vivo real-time imaging of murine tissues. Development of a suction device for stabilizing in vivo real-time imaging of murine tissues. Development of a suction device for stabilizing in vivo real-time imaging of murine tissues Journal of bioscience and bioengineering, 112, 5, 508-510 Journal of bioscience and bioengineering, 112, 5, 508-510 Journal of Bioscience and Bioengineering, 112, 5, 508-510 2011/11 英語 公開
Higuchi Y, Wu C, Chang KL, Irie K, Kawakami S, Yamashita F, Hashida M Higuchi Y, Wu C, Chang KL, Irie K, Kawakami S, Yamashita F, Hashida M Y. Higuchi; C. Wu; K.-L. Chang; K. Irie; S. Kawakami; F. Yamashita; M. Hashida Polyamidoamine dendrimer-conjugated quantum dots for efficient labeling of primary cultured mesenchymal stem cells. Polyamidoamine dendrimer-conjugated quantum dots for efficient labeling of primary cultured mesenchymal stem cells. Polyamidoamine dendrimer-conjugated quantum dots for efficient labeling of primary cultured mesenchymal stem cells Biomaterials, 32, 28, 6676-6682 Biomaterials, 32, 28, 6676-6682 Biomaterials, 32, 28, 6676-6682 2011/10 英語 公開
Nakanishi H, Higuchi Y, Kawakami S, Yamashita F, Hashida M Nakanishi H, Higuchi Y, Kawakami S, Yamashita F, Hashida M H. Nakanishi; Y. Higuchi; S. Kawakami; F. Yamashita; M. Hashida Comparison of piggyBac transposition efficiency between linear and circular donor vectors in mammalian cells. Comparison of piggyBac transposition efficiency between linear and circular donor vectors in mammalian cells. Comparison of piggyBac transposition efficiency between linear and circular donor vectors in mammalian cells Journal of biotechnology, 154, 4, 205-208 Journal of biotechnology, 154, 4, 205-208 Journal of Biotechnology, 154, 4, 205-208 2011/07/20 英語 公開
Un K, Kawakami S, Yoshida M, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M Un K, Kawakami S, Yoshida M, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M K. Un; S. Kawakami; M. Yoshida; Y. Higuchi; R. Suzuki; K. Maruyama; F. Yamashita; M. Hashida The elucidation of gene transferring mechanism by ultrasound-responsive unmodified and mannose-modified lipoplexes. The elucidation of gene transferring mechanism by ultrasound-responsive unmodified and mannose-modified lipoplexes. The elucidation of gene transferring mechanism by ultrasound-responsive unmodified and mannose-modified lipoplexes Biomaterials, 32, 20, 4659-4669 Biomaterials, 32, 20, 4659-4669 Biomaterials, 32, 20, 4659-4669 2011/07 英語 公開
Dinh TD, Higuchi Y, Kawakami S, Yamashita F, Hashida M Dinh TD, Higuchi Y, Kawakami S, Yamashita F, Hashida M T.D. Dinh; Y. Higuchi; S. Kawakami; F. Yamashita; M. Hashida Evaluation of osteoclastogenesis via NFκB decoy/mannosylated cationic liposome-mediated inhibition of pro-inflammatory cytokine production from primary cultured macrophages. Evaluation of osteoclastogenesis via NFκB decoy/mannosylated cationic liposome-mediated inhibition of pro-inflammatory cytokine production from primary cultured macrophages. Evaluation of osteoclastogenesis via NFκB decoy/mannosylated cationic liposome-mediated inhibition of Pro-inflammatory cytokine production from primary cultured macrophages Pharmaceutical research, 28, 4, 742-751 Pharmaceutical research, 28, 4, 742-751 Pharmaceutical Research, 28, 4, 742-751 2011/04 英語 公開
Wijagkanalan W, Kawakami S, Higuchi Y, Yamashita F, Hashida M Wijagkanalan W, Kawakami S, Higuchi Y, Yamashita F, Hashida M W. Wijagkanalan; S. Kawakami; Y. Higuchi; F. Yamashita; M. Hashida Intratracheally instilled mannosylated cationic liposome/NFκB decoy complexes for effective prevention of LPS-induced lung inflammation. Intratracheally instilled mannosylated cationic liposome/NFκB decoy complexes for effective prevention of LPS-induced lung inflammation. Intratracheally instilled mannosylated cationic liposome/NFκB decoy complexes for effective prevention of LPS-induced lung inflammation Journal of controlled release : official journal of the Controlled Release Society, 149, 1, 42-50 Journal of controlled release : official journal of the Controlled Release Society, 149, 1, 42-50 Journal of Controlled Release, 149, 1, 42-50 2011/01 英語 公開
Chang KL, Higuchi Y, Kawakami S, Yamashita F, Hashida M Chang KL, Higuchi Y, Kawakami S, Yamashita F, Hashida M K.-L. Chang; Y. Higuchi; S. Kawakami; F. Yamashita; M. Hashida Efficient gene transfection by histidine-modified chitosan through enhancement of endosomal escape. Efficient gene transfection by histidine-modified chitosan through enhancement of endosomal escape. Efficient gene transfection by histidine-modified chitosan through enhancement of endosomal escape Bioconjugate chemistry, 21, 6, 1087-1095 Bioconjugate chemistry, 21, 6, 1087-1095 Bioconjugate Chemistry, 21, 6, 1087-1095 2010/06 英語 公開
Higuchi Y, Kawakami S, Hashida M Higuchi Y, Kawakami S, Hashida M Y. Higuchi; S. Kawakami; M. Hashida Strategies for in vivo delivery of siRNAs: recent progress. Strategies for in vivo delivery of siRNAs: recent progress. Strategies for in vivo delivery of siRNAs: Recent progress BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 24, 3, 195-205 BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 24, 3, 195-205 BioDrugs, 24, 3, 195-205 2010/06 英語 公開
Nakanishi H, Higuchi Y, Kawakami S, Yamashita F, Hashida M Nakanishi H, Higuchi Y, Kawakami S, Yamashita F, Hashida M H. Nakanishi; Y. Higuchi; S. Kawakami; F. Yamashita; M. Hashida piggyBac transposon-mediated long-term gene expression in mice. piggyBac transposon-mediated long-term gene expression in mice. PiggyBac transposon-mediated long-term gene expression in mice Molecular therapy : the journal of the American Society of Gene Therapy, 18, 4, 707-714 Molecular therapy : the journal of the American Society of Gene Therapy, 18, 4, 707-714 Molecular Therapy, 18, 4, 707-714 2010/04 英語 公開
Kurosaki T, Kitahara T, Kawakami S, Higuchi Y, Yamaguchi A, Nakagawa H, Kodama Y, Hamamoto T, Hashida M, Sasaki H Kurosaki T, Kitahara T, Kawakami S, Higuchi Y, Yamaguchi A, Nakagawa H, Kodama Y, Hamamoto T, Hashida M, Sasaki H T. Kurosaki; T. Kitahara; S. Kawakami; Y. Higuchi; A. Yamaguchi; H. Nakagawa; Y. Kodama; T. Hamamoto; M. Hashida; H. Sasaki Gamma-polyglutamic acid-coated vectors for effective and safe gene therapy. Gamma-polyglutamic acid-coated vectors for effective and safe gene therapy. γ-Polyglutamic acid-coated vectors for effective and safe gene therapy Journal of controlled release : official journal of the Controlled Release Society, 142, 3, 404-410 Journal of controlled release : official journal of the Controlled Release Society, 142, 3, 404-410 Journal of Controlled Release, 142, 3, 404-410 2010/03 英語 公開
H. Nakanishi; Y. Higuchi; S. Kawakami; F. Yamashita; M. Hashida H. Nakanishi; Y. Higuchi; S. Kawakami; F. Yamashita; M. Hashida Nakanishi H, Higuchi Y, Kawakami S, Yamashita F, Hashida M Development and therapeutic application of transposon-based vectors Development and therapeutic application of transposon-based vectors [Development and therapeutic application of transposon-based vectors]. Yakugaku Zasshi, 129, 12, 1433-1443 Yakugaku Zasshi, 129, 12, 1433-1443 Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 129, 12, 1433-1443 2009/12 日本語 公開
Nakamura K, Kuramoto Y, Mukai H, Kawakami S, Higuchi Y, Hashida M Nakamura K, Kuramoto Y, Mukai H, Kawakami S, Higuchi Y, Hashida M K. Nakamura; Y. Kuramoto; H. Mukai; S. Kawakami; Y. Higuchi; M. Hashida Enhanced gene transfection in macrophages by histidine-conjugated mannosylated cationic liposomes. Enhanced gene transfection in macrophages by histidine-conjugated mannosylated cationic liposomes. Enhanced gene transfection in macrophages by histidine-conjugated mannosylated cationic liposomes Biological & pharmaceutical bulletin, 32, 9, 1628-1631 Biological & pharmaceutical bulletin, 32, 9, 1628-1631 Biological and Pharmaceutical Bulletin, 32, 9, 1628-1631 2009/09 英語 公開
Sugao Y, Watanabe K, Higuchi Y, Kurihara R, Kawakami S, Hashida M, Katayama Y, Niidome T Sugao Y, Watanabe K, Higuchi Y, Kurihara R, Kawakami S, Hashida M, Katayama Y, Niidome T Y. Sugao; K. Watanabe; Y. Higuchi; R. Kurihara; S. Kawakami; M. Hashida; Y. Katayama; T. Niidome NFkappaB decoy delivery using dendritic poly(l-lysine) for treatment of endotoxin-induced hepatitis in mice. NFkappaB decoy delivery using dendritic poly(l-lysine) for treatment of endotoxin-induced hepatitis in mice. NFκB decoy delivery using dendritic poly(l-lysine) for treatment of endotoxin-induced hepatitis in mice Bioorganic & medicinal chemistry, 17, 14, 4990-4995 Bioorganic & medicinal chemistry, 17, 14, 4990-4995 Bioorganic and Medicinal Chemistry, 17, 14, 4990-4995 2009/07 英語 公開
Satoh T, Higuchi Y, Kawakami S, Hashida M, Kagechika H, Shudo K, Yokoyama M Satoh T, Higuchi Y, Kawakami S, Hashida M, Kagechika H, Shudo K, Yokoyama M T. Satoh; Y. Higuchi; S. Kawakami; M. Hashida; H. Kagechika; K. Shudo; M. Yokoyama Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids' release control. Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids' release control. Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids\\' release control Journal of controlled release : official journal of the Controlled Release Society, 136, 3, 187-195 Journal of controlled release : official journal of the Controlled Release Society, 136, 3, 187-195 Journal of Controlled Release, 136, 3, 187-195 2009/06/19 英語 公開
Okuda T, Kawakami S, Higuchi Y, Satoh T, Oka Y, Yokoyama M, Yamashita F, Hashida M Okuda T, Kawakami S, Higuchi Y, Satoh T, Oka Y, Yokoyama M, Yamashita F, Hashida M T. Okuda; S. Kawakami; Y. Higuchi; T. Satoh; Y. Oka; M. Yokoyama; F. Yamashita; M. Hashida Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles. Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles. Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles International journal of pharmaceutics, 373, 1-2, 100-106 International journal of pharmaceutics, 373, 1-2, 100-106 International Journal of Pharmaceutics, 373, 1-2, 100-106 2009/05 英語 公開
Saito Y, Higuchi Y, Kawakami S, Yamashita F, Hashida M Saito Y, Higuchi Y, Kawakami S, Yamashita F, Hashida M Y. Saito; Y. Higuchi; S. Kawakami; F. Yamashita; M. Hashida Immunostimulatory characteristics induced by linear polyethyleneimine-plasmid DNA complexes in cultured macrophages. Immunostimulatory characteristics induced by linear polyethyleneimine-plasmid DNA complexes in cultured macrophages. Immunostimulatory characteristics induced by linear polyethyleneimine- plasmid DNA complexes in cultured macrophages Human gene therapy, 20, 2, 137-145 Human gene therapy, 20, 2, 137-145 Human Gene Therapy, 20, 2, 137-145 2009/02 英語 公開
Ito Y, Kawakami S, Charoensit P, Higuchi Y, Hashida M Ito Y, Kawakami S, Charoensit P, Higuchi Y, Hashida M Y. Ito; S. Kawakami; P. Charoensit; Y. Higuchi; M. Hashida Evaluation of proinflammatory cytokine production and liver injury induced by plasmid DNA/cationic liposome complexes with various mixing ratios in mice. Evaluation of proinflammatory cytokine production and liver injury induced by plasmid DNA/cationic liposome complexes with various mixing ratios in mice. Evaluation of proinflammatory cytokine production and liver injury induced by plasmid DNA/cationic liposome complexes with various mixing ratios in mice European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 71, 2, 303-309 European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 71, 2, 303-309 European Journal of Pharmaceutics and Biopharmaceutics, 71, 2, 303-309 2009/02 英語 公開
Huang H, Sakurai F, Higuchi Y, Kawakami S, Hashida M, Kawabata K, Mizuguchi H Huang H, Sakurai F, Higuchi Y, Kawakami S, Hashida M, Kawabata K, Mizuguchi H H. Huang; F. Sakurai; Y. Higuchi; S. Kawakami; M. Hashida; K. Kawabata; H. Mizuguchi Suppressive effects of sugar-modified cationic liposome/NF-kappaB decoy complexes on adenovirus vector-induced innate immune responses. Suppressive effects of sugar-modified cationic liposome/NF-kappaB decoy complexes on adenovirus vector-induced innate immune responses. Suppressive effects of sugar-modified cationic liposome/NF-κB decoy complexes on adenovirus vector-induced innate immune responses Journal of controlled release : official journal of the Controlled Release Society, 133, 2, 139-145 Journal of controlled release : official journal of the Controlled Release Society, 133, 2, 139-145 Journal of Controlled Release, 133, 2, 139-145 2009/01 英語 公開
Wijagkanalan W, Higuchi Y, Kawakami S, Teshima M, Sasaki H, Hashida M Wijagkanalan W, Higuchi Y, Kawakami S, Teshima M, Sasaki H, Hashida M W. Wijagkanalan; Y. Higuchi; S. Kawakami; M. Teshima; H. Sasaki; M. Hashida Enhanced anti-inflammation of inhaled dexamethasone palmitate using mannosylated liposomes in an endotoxin-induced lung inflammation model. Enhanced anti-inflammation of inhaled dexamethasone palmitate using mannosylated liposomes in an endotoxin-induced lung inflammation model. Enhanced anti-inflammation of inhaled dexamethasone palmitate using mannosylated liposomes in an endotoxin-induced lung inflammation model Molecular pharmacology, 74, 5, 1183-1192 Molecular pharmacology, 74, 5, 1183-1192 Molecular Pharmacology, 74, 5, 1183-1192 2008/11 英語 公開
Higuchi Yuriko, Wu Can, Kawakami Shigeru, Hashida Mitsuru Higuchi Yuriko, Wu Can, Kawakami Shigeru, Hashida Mitsuru Higuchi Yuriko, Wu Can, Kawakami Shigeru, Hashida Mitsuru Kupffer cell targeted delivery of nfkb decoy suppress hepatic ishchemia/reperfusion injury Kupffer cell targeted delivery of nfkb decoy suppress hepatic ishchemia/reperfusion injury Kupffer cell targeted delivery of nfkb decoy suppress hepatic ishchemia/reperfusion injury JOURNAL OF GENE MEDICINE, 10, 4, 448 JOURNAL OF GENE MEDICINE, 10, 4, 448 JOURNAL OF GENE MEDICINE, 10, 4, 448 2008/04 公開
Kawakami S, Higuchi Y, Hashida M Kawakami S, Higuchi Y, Hashida M S. Kawakami; Y. Higuchi; M. Hashida Nonviral approaches for targeted delivery of plasmid DNA and oligonucleotide. Nonviral approaches for targeted delivery of plasmid DNA and oligonucleotide. Nonviral approaches for targeted delivery of plasmid DNA and oligonucleotide Journal of pharmaceutical sciences, 97, 2, 726-745 Journal of pharmaceutical sciences, 97, 2, 726-745 Journal of Pharmaceutical Sciences, 97, 2, 726-745 2008/02 英語 公開
Y. Higuchi; S. Kawakami; M. Hashida Y. Higuchi; S. Kawakami; M. Hashida Higuchi Y, Kawakami S, Hashida M Development of cell-selective targeting systems of NFκB decoy for inflammation therapy Development of cell-selective targeting systems of NFκB decoy for inflammation therapy [Development of cell-selective targeting systems of NFkappaB decoy for inflammation therapy]. Yakugaku Zasshi, 128, 2, 209-218 Yakugaku Zasshi, 128, 2, 209-218 Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 128, 2, 209-218 2008/02 日本語 公開
Charoensit P, Kawakami S, Higuchi Y, Hashida M Charoensit P, Kawakami S, Higuchi Y, Hashida M P. Charoensit; S. Kawakami; Y. Higuchi; M. Hashida Incorporation of all-trans retinoic acid into lipoplexes inhibits nuclear factor kappaB activation mediated liver injury induced by lipoplexes in mice. Incorporation of all-trans retinoic acid into lipoplexes inhibits nuclear factor kappaB activation mediated liver injury induced by lipoplexes in mice. Incorporation of all-trans retinoic acid into lipoplexes inhibits nuclear factor κB activation mediated liver injury induced by lipoplexes in mice The journal of gene medicine, 10, 1, 61-69 The journal of gene medicine, 10, 1, 61-69 Journal of Gene Medicine, 10, 1, 61-69 2008/01 英語 公開
Higuchi Y, Oka M, Kawakami S, Hashida M Higuchi Y, Oka M, Kawakami S, Hashida M Y. Higuchi; M. Oka; S. Kawakami; M. Hashida Mannosylated semiconductor quantum dots for the labeling of macrophages. Mannosylated semiconductor quantum dots for the labeling of macrophages. Mannosylated semiconductor quantum dots for the labeling of macrophages Journal of controlled release : official journal of the Controlled Release Society, 125, 2, 131-136 Journal of controlled release : official journal of the Controlled Release Society, 125, 2, 131-136 Journal of Controlled Release, 125, 2, 131-136 2008/01 英語 公開
Shigeta K, Kawakami S, Higuchi Y, Okuda T, Yagi H, Yamashita F, Hashida M Shigeta K, Kawakami S, Higuchi Y, Okuda T, Yagi H, Yamashita F, Hashida M K. Shigeta; S. Kawakami; Y. Higuchi; T. Okuda; H. Yagi; F. Yamashita; M. Hashida Novel histidine-conjugated galactosylated cationic liposomes for efficient hepatocyte-selective gene transfer in human hepatoma HepG2 cells. Novel histidine-conjugated galactosylated cationic liposomes for efficient hepatocyte-selective gene transfer in human hepatoma HepG2 cells. Novel histidine-conjugated galactosylated cationic liposomes for efficient hepatocyte-selective gene transfer in human hepatoma HepG2 cells Journal of controlled release : official journal of the Controlled Release Society, 118, 2, 262-270 Journal of controlled release : official journal of the Controlled Release Society, 118, 2, 262-270 Journal of Controlled Release, 118, 2, 262-270 2007/04 英語 公開
Higuchi Y, Kawakami S, Yamashita F, Hashida M Higuchi Y, Kawakami S, Yamashita F, Hashida M Y. Higuchi; S. Kawakami; F. Yamashita; M. Hashida The potential role of fucosylated cationic liposome/NFkappaB decoy complexes in the treatment of cytokine-related liver disease. The potential role of fucosylated cationic liposome/NFkappaB decoy complexes in the treatment of cytokine-related liver disease. The potential role of fucosylated cationic liposome/NFκB decoy complexes in the treatment of cytokine-related liver disease Biomaterials, 28, 3, 532-539 Biomaterials, 28, 3, 532-539 Biomaterials, 28, 3, 532-539 2007/01 英語 公開
Higuchi Y, Hashida M Higuchi Y, Hashida M Y. Higuchi; M. Hashida [Pharmaceutical device of IFN]. [Pharmaceutical device of IFN]. Pharmaceutical device of IFN Nihon rinsho. Japanese journal of clinical medicine, 64, 7, 1374-1379 Nihon rinsho. Japanese journal of clinical medicine, 64, 7, 1374-1379 Nippon rinsho. Japanese journal of clinical medicine., 64, 7, 1374-1379 2006/07 英語 公開
Higuchi Y, Kawakami S, Fumoto S, Yamashita F, Hashida M Higuchi Y, Kawakami S, Fumoto S, Yamashita F, Hashida M Y. Higuchi; S. Kawakami; S. Fumoto; F. Yamashita; M. Hashida Effect of the particle size of galactosylated lipoplex on hepatocyte-selective gene transfection after intraportal administration. Effect of the particle size of galactosylated lipoplex on hepatocyte-selective gene transfection after intraportal administration. Effect of the particle size of galactosylated lipoplex on hepatocyte-selective gene transfection after intraportal administration Biological & pharmaceutical bulletin, 29, 7, 1521-1523 Biological & pharmaceutical bulletin, 29, 7, 1521-1523 Biological and Pharmaceutical Bulletin, 29, 7, 1521-1523 2006/07 英語 公開
Higuchi Y, Kawakami S, Oka M, Yabe Y, Yamashita F, Hashida M Higuchi Y, Kawakami S, Oka M, Yabe Y, Yamashita F, Hashida M Y. Higuchi; S. Kawakami; M. Oka; Y. Yabe; F. Yamashita; M. Hashida Intravenous administration of mannosylated cationic liposome/NFkappaB decoy complexes effectively prevent LPS-induced cytokine production in a murine liver failure model. Intravenous administration of mannosylated cationic liposome/NFkappaB decoy complexes effectively prevent LPS-induced cytokine production in a murine liver failure model. Intravenous administration of mannosylated cationic liposome/NFκB decoy complexes effectively prevent LPS-induced cytokine production in a murine liver failure model FEBS letters, 580, 15, 3706-3714 FEBS letters, 580, 15, 3706-3714 FEBS Letters, 580, 15, 3706-3714 2006/06 英語 公開
Fumoto S, Kawakami S, Shigeta K, Higuchi Y, Yamashita F, Hashida M Fumoto S, Kawakami S, Shigeta K, Higuchi Y, Yamashita F, Hashida M S. Fumoto; S. Kawakami; K. Shigeta; Y. Higuchi; F. Yamashita; M. Hashida Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex. Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex. Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex The Journal of pharmacology and experimental therapeutics, 315, 2, 484-493 The Journal of pharmacology and experimental therapeutics, 315, 2, 484-493 Journal of Pharmacology and Experimental Therapeutics, 315, 2, 484-493 2005/11 英語 公開
Higuchi Y, Kawakami S, Nishikawa M, Yamashita F, Hashida M Higuchi Y, Kawakami S, Nishikawa M, Yamashita F, Hashida M Y. Higuchi; S. Kawakami; M. Nishikawa; F. Yamashita; M. Hashida Intracellular distribution of NFkappaB decoy and its inhibitory effect on TNFalpha production by LPS stimulated RAW 264.7 cells. Intracellular distribution of NFkappaB decoy and its inhibitory effect on TNFalpha production by LPS stimulated RAW 264.7 cells. Intracellular distribution of NFκB decoy and its inhibitory effect on TNFα production by LPS stimulated RAW 264.7 cells Journal of controlled release : official journal of the Controlled Release Society, 107, 2, 373-382 Journal of controlled release : official journal of the Controlled Release Society, 107, 2, 373-382 Journal of Controlled Release, 107, 2, 373-382 2005/10 英語 公開
Yeeprae W, Kawakami S, Higuchi Y, Yamashita F, Hashida M Yeeprae W, Kawakami S, Higuchi Y, Yamashita F, Hashida M W. Yeeprae; S. Kawakami; Y. Higuchi; F. Yamashita; M. Hashida Biodistribution characteristics of mannosylated and fucosylated O/W emulsions in mice. Biodistribution characteristics of mannosylated and fucosylated O/W emulsions in mice. Biodistribution characteristics of mannosylated and fucosylated O/W emulsions in mice Journal of drug targeting, 13, 8-9, 479-487 Journal of drug targeting, 13, 8-9, 479-487 Journal of Drug Targeting, 13, 8-9, 479-487 2005/09 英語 公開
Higuchi Y, Nishikawa M, Kawakami S, Yamashita F, Hashida M Higuchi Y, Nishikawa M, Kawakami S, Yamashita F, Hashida M Y. Higuchi; M. Nishikawa; S. Kawakami; F. Yamashita; M. Hashida Uptake characteristics of mannosylated and fucosylated bovine serum albumin in primary cultured rat sinusoidal endothelial cells and Kupffer cells. Uptake characteristics of mannosylated and fucosylated bovine serum albumin in primary cultured rat sinusoidal endothelial cells and Kupffer cells. Uptake characteristics of mannosylated and fucosylated bovine serum albumin in primary cultured rat sinusoidal endothelial cells and Kupffer cells International journal of pharmaceutics, 287, 1-2, 147-154 International journal of pharmaceutics, 287, 1-2, 147-154 International Journal of Pharmaceutics, 287, 1-2, 147-154 2004/12 英語 公開
P. Charoensit; S. Kawakami; Y. Higuchi; F. Yamashita; M. Hashida P. Charoensit; S. Kawakami; Y. Higuchi; F. Yamashita; M. Hashida Enhanced growth inhibition of metastatic lung tumors by intravenous injection of ATRA-cationic liposome/IL-12 pDNA complexes in mice Enhanced growth inhibition of metastatic lung tumors by intravenous injection of ATRA-cationic liposome/IL-12 pDNA complexes in mice Cancer Gene Therapy, 17, 7, 512-522 , 17, 7, 512-522 Cancer Gene Therapy, 17, 7, 512-522 2010/07 英語 公開
M. Hohokabe; Y. Higuchi; H. Mukai; S. Kawakami; M. Hashida M. Hohokabe; Y. Higuchi; H. Mukai; S. Kawakami; M. Hashida Hepatocyte-selective gene transfer by galactosylated protein/linear polyethyleneimine/plasmid DNA complexes in mice Hepatocyte-selective gene transfer by galactosylated protein/linear polyethyleneimine/plasmid DNA complexes in mice Journal of Biomedical Nanotechnology, 3, 3, 277-284 , 3, 3, 277-284 Journal of Biomedical Nanotechnology, 3, 3, 277-284 2007 英語 公開
Y. Higuchi; S. Kawakami; M. Nishikawa; F. Yamashita; M. Hashida Y. Higuchi; S. Kawakami; M. Nishikawa; F. Yamashita; M. Hashida Erratum: Intracellular distribution of NFκB decoy and its inhibitory effect on TNFα production by LPS stimulated RAW 264.7 cells (Journal of Controlled Release (2005) 107 (373-382) DOI: 10.1016/j.jconrel.2005.07.004) Erratum: Intracellular distribution of NFκB decoy and its inhibitory effect on TNFα production by LPS stimulated RAW 264.7 cells (Journal of Controlled Release (2005) 107 (373-382) DOI: 10.1016/j.jconrel.2005.07.004) Journal of Controlled Release, 111, 3, 390 , 111, 3, 390 Journal of Controlled Release, 111, 3, 390 2006 英語 公開
Y. Higuchi; S. Kawakami; M. Oka; F. Yamashita; M. Hashida Y. Higuchi; S. Kawakami; M. Oka; F. Yamashita; M. Hashida Suppression of TNFα production in LPS induced liver failure in mice after intravenous injection of cationic liposomes/NFκB decoy complex Suppression of TNFα production in LPS induced liver failure in mice after intravenous injection of cationic liposomes/NFκB decoy complex Pharmazie, 61, 2, 144-147 , 61, 2, 144-147 Pharmazie, 61, 2, 144-147 2006 英語 公開
S. Kawakami; Y. Hattori; Y. Lu; Y. Higuchi; F. Yamashita; M. Hashida S. Kawakami; Y. Hattori; Y. Lu; Y. Higuchi; F. Yamashita; M. Hashida Effect of cationic charge on receptor-mediated transfection using mannosylated cationic liposome/plasmid DNA complexes following the intravenous administration in mice Effect of cationic charge on receptor-mediated transfection using mannosylated cationic liposome/plasmid DNA complexes following the intravenous administration in mice Pharmazie, 59, 5, 405-408 , 59, 5, 405-408 Pharmazie, 59, 5, 405-408 2004 英語 公開
P. Opanasopit; Y. Higuchi; S. Kawakami; F. Yamashita; M. Nishikawa; M. Hashida P. Opanasopit; Y. Higuchi; S. Kawakami; F. Yamashita; M. Nishikawa; M. Hashida Involvement of serum mannan binding proteins and mannose receptors in uptake of mannosylated liposomes by macrophages Involvement of serum mannan binding proteins and mannose receptors in uptake of mannosylated liposomes by macrophages Biochimica et Biophysica Acta - Biomembranes, 1511, 134-145 , 1511, 134-145 Biochimica et Biophysica Acta - Biomembranes, 1511, 134-145 2001/03/09 英語 公開

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著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
E. Miyako; T. Deguchi; Y. Nakajima; M. Yudasaka; Y. Hagihara; M. Horie; M. Shichiri; Y. Higuchi; F. Yamashita; M. Hashida; Y. Shigeri; Y. Yoshida; S. Iijima E. Miyako; T. Deguchi; Y. Nakajima; M. Yudasaka; Y. Hagihara; M. Horie; M. Shichiri; Y. Higuchi; F. Yamashita; M. Hashida; Y. Shigeri; Y. Yoshida; S. Iijima Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns Proceedings of the National Academy of Sciences of the United States of America, 109, 19, 7523-7528 , 109, 19, 7523-7528 Proceedings of the National Academy of Sciences of the United States of America, 109, 19, 7523-7528 2012/05/08 英語 公開
K. Watanabe; M. Harada-Shiba; A. Suzuki; Y. Higuchi; S. Kawakami; M. Hashida; R. Gokuden; R. Kurihara; Y. Sugao; T. Mori; Y. Katayama; T. Niidome K. Watanabe; M. Harada-Shiba; A. Suzuki; Y. Higuchi; S. Kawakami; M. Hashida; R. Gokuden; R. Kurihara; Y. Sugao; T. Mori; Y. Katayama; T. Niidome Oligonuleotide delivery with dendritic poly(L-lysine) for treatments of the liver disorders Oligonuleotide delivery with dendritic poly(L-lysine) for treatments of the liver disorders Materials Research Society Symposium Proceedings, 1237, 12-17 , 1237, 12-17 Materials Research Society Symposium Proceedings, 1237, 12-17 2010 英語 公開
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発明者 発明者(日本語) 発明者(英語) 発明の名称 発明の名称(日本語) 発明の名称(英語) 審査の段階 番号 年月 公開
樋口ゆり子、橋田充、小西聡 樋口ゆり子、橋田充、小西聡 生体観察用治具 生体観察用治具 特許出願 特願2016-096002 2016/05/12 公開
橋田充、山下富義、樋口ゆり子、チャニカーン チャンタラスリウォン、川上茂、ヨハン ウンガ、木曽真、植木章晴、安藤弘宗 橋田充、山下富義、樋口ゆり子、チャニカーン チャンタラスリウォン、川上茂、ヨハン ウンガ、木曽真、植木章晴、安藤弘宗 糖誘導体、またはその塩、セレクチン結合剤、糖結合体、粒子状キャリア、および輸送方法 糖誘導体、またはその塩、セレクチン結合剤、糖結合体、粒子状キャリア、および輸送方法 特許出願 特願2015-043050 2015/03/05 公開
樋口ゆり子、清水一憲、小西聡、橋田充 樋口ゆり子、清水一憲、小西聡、橋田充 生体試料固定器 生体試料固定器 特許公表 特表第5930364号 公開
橋田泰彦、橋田 充、樋口ゆり子、今堀博、梅山有和、磯田正二、辻本将彦 橋田泰彦、橋田 充、樋口ゆり子、今堀博、梅山有和、磯田正二、辻本将彦 自己会合によって均一な表面構造を形成するペプチドとカーボンナノチューブからなる複合炭素素材 自己会合によって均一な表面構造を形成するペプチドとカーボンナノチューブからなる複合炭素素材 特許出願 特願2011-68972 2011/03/25 公開
横山昌幸、佐藤 琢、川上 茂、樋口ゆり子、橋田 充 横山昌幸、佐藤 琢、川上 茂、樋口ゆり子、橋田 充 活性成分封入高分子ミセル及び活性成分の溶出制御方法 活性成分封入高分子ミセル及び活性成分の溶出制御方法 特許出願 特願2008-292740 2008/11/14 公開
川上 茂、橋田 充、樋口ゆり子 川上 茂、橋田 充、樋口ゆり子 免疫担当細胞指向型オリゴヌクレオチド・リポソーム複合体 免疫担当細胞指向型オリゴヌクレオチド・リポソーム複合体 特許公開 特開2006-193488 公開
タイトル言語:
学術賞等
賞の名称(日本語) 賞の名称(英語) 授与組織名(日本語) 授与組織名(英語) 年月
平成20年度日本薬学会近畿支部奨励賞 日本薬学会近畿支部 2009/01/
第5回日本DDS学会奨励賞 日本DDS学会 2013/07/05
日本薬剤学会奨励賞 日本薬剤学会 2015/05/22
外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
若手研究(B) 代表 体内動態追跡を目的とした細胞標識のための多機能性量子ドットの開発 2009〜2010
挑戦的萌芽研究 代表 PEG脂質と外部刺激を利用した新規細胞膜表面修飾法の開発 2012〜2013
若手研究(A) 代表 ユビキチンプロテアソーム経路を利用した新規遺伝子発現制御に基づく細胞制御法の開発 2013〜2015
挑戦的萌芽研究 代表 PEG脂質を介した低分子抗体の細胞膜表面修飾による細胞選択的接着の向上 2016/04/01〜2019/03/31
基盤研究(B) 代表 細胞膜表面の低分子抗体修飾による細胞製剤の標的指向化 2018/04/01〜2022/03/31
若手(B) 代表 転写制御による炎症性疾患に対する新規治療法の開発 2006〜2007
外部資金:競争的資金・科学研究費補助金以外
制度名 代表者名 研究課題(日本語) 研究課題(英語) 期間
平成21年度厚生労働科学研究費補助金政策創薬総合研究事業 若手研究者奨励研究 樋口ゆり子 新規多機能性キトサンによる遺伝子導入システムの開発とDNAワクチンへの応用 2009〜2011
戦略的創造研究推進事業 さきがけ 樋口ゆり子 蛍光イメージングによる幹細胞挙動解析法の創成 2009〜2013
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
薬学専門実習3 Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology 後期 薬学部 2014/04〜2015/03
医療実務事前学習 Pre-Training for Clinical Clerkship 後期前期 薬学部 2014/04〜2015/03
薬物動態学(LIMS) Biopharmaceutics 後期集中 医学研究科 2014/04〜2015/03
医療実務事前学習 Pre-Training for Clinical Clerkship 後期前期 薬学部 2015/04〜2016/03
薬学専門実習3 Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology 後期 薬学部 2015/04〜2016/03
薬物動態学(LIMS) Biopharmaceutics 後期集中 医学研究科 2015/04〜2016/03
医療実務事前学習 Pre-Training for Clinical Clerkship 後期前期 薬学部 2016/04〜2017/03
薬学専門実習3 Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology 後期 薬学部 2016/04〜2017/03
薬物動態学 Biopharmaceutics 後期 工学研究科 2016/04〜2017/03
薬物動態学(LIMS) Biopharmaceutics 後期集中 医学研究科 2016/04〜2017/03
医療実務事前学習 Pre-Training for Clinical Clerkship 後期前期 薬学部 2017/04〜2018/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 前期不定 薬学研究科 2017/04〜2018/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 後期不定 薬学研究科 2017/04〜2018/03
基盤薬品動態医療薬学実習 Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences 通年不定 薬学研究科 2017/04〜2018/03
基盤薬品動態医療薬学実験 Research in Basic Pharmacology and Drug Delivery 通年不定 薬学研究科 2017/04〜2018/03
基盤薬品動態医療薬学演習 Basic Pharmacology and Drug Delivery Research Seminar 通年不定 薬学研究科 2017/04〜2018/03
臨床薬学演習Ⅲ Seminar for Clinical Pharmacy III 通年不定 薬学研究科 2017/04〜2018/03
臨床薬学演習Ⅱ Seminar for Clinical Pharmacy II 通年不定 薬学研究科 2017/04〜2018/03
臨床薬学演習Ⅰ Seminar for Clinical Pharmacy I 通年不定 薬学研究科 2017/04〜2018/03
薬学実験技術 Basic Laboratory Techniques in Pharmaceutical Sciences 前期不定 薬学研究科 2017/04〜2018/03
薬学専門実習3 Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology 後期 薬学部 2017/04〜2018/03
薬学研究実習Ⅱ Laboratory Practice in Pharmaceutical Sciences II 通年不定 薬学研究科 2017/04〜2018/03
薬学研究実習Ⅰ Laboratory Practice in Pharmaceutical Sciences I 通年不定 薬学研究科 2017/04〜2018/03
薬学研究実験Ⅲ Research in Pharmaceutical Sciences III 通年不定 薬学研究科 2017/04〜2018/03
薬学研究実験Ⅱ Research in Pharmaceutical Sciences II 通年不定 薬学研究科 2017/04〜2018/03
薬学研究実験Ⅰ Research in Pharmaceutical Sciences I 通年不定 薬学研究科 2017/04〜2018/03
薬局方・薬事関連法規 Pharmacopoeia ; Pharmaceutical Laws 前期 薬学部 2017/04〜2018/03
薬物動態学 Biopharmaceutics 後期 工学研究科 2017/04〜2018/03
薬物動態学(LIMS) Biopharmaceutics (LIMS) 後期集中 医学研究科 2017/04〜2018/03
医薬品開発プロジェクト演習I Pharmaceutical R&D Exercise I 前期 薬学部 2018/04〜2019/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 前期不定 薬学研究科 2018/04〜2019/03
基盤医療薬科学実験技術 Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences 後期不定 薬学研究科 2018/04〜2019/03
基盤薬品動態医療薬学実習 Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences 通年不定 薬学研究科 2018/04〜2019/03
基盤薬品動態医療薬学実験 Research in Basic Pharmacology and Drug Delivery 通年不定 薬学研究科 2018/04〜2019/03
基盤薬品動態医療薬学演習 Basic Pharmacology and Drug Delivery Research Seminar 通年不定 薬学研究科 2018/04〜2019/03
臨床薬学演習Ⅲ Seminar for Clinical Pharmacy III 通年不定 薬学研究科 2018/04〜2019/03
臨床薬学演習Ⅱ Seminar for Clinical Pharmacy II 通年不定 薬学研究科 2018/04〜2019/03
臨床薬学演習Ⅰ Seminar for Clinical Pharmacy I 通年不定 薬学研究科 2018/04〜2019/03
薬学実験技術 Basic Laboratory Techniques in Pharmaceutical Sciences 前期不定 薬学研究科 2018/04〜2019/03
薬学実験技術 Basic Laboratory Techniques in Pharmaceutical Sciences 後期不定 薬学研究科 2018/04〜2019/03
薬学専門実習3 Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology 後期 薬学部 2018/04〜2019/03
薬学研究実習Ⅱ Laboratory Practice in Pharmaceutical Sciences II 後期前期 薬学研究科 2018/04〜2019/03
薬学研究実習Ⅱ Laboratory Practice in Pharmaceutical Sciences II 通年不定 薬学研究科 2018/04〜2019/03
薬学研究実習Ⅰ Laboratory Practice in Pharmaceutical Sciences I 後期前期 薬学研究科 2018/04〜2019/03
薬学研究実習Ⅰ Laboratory Practice in Pharmaceutical Sciences I 通年不定 薬学研究科 2018/04〜2019/03
薬学研究実験Ⅲ Research in Pharmaceutical Sciences III 通年不定 薬学研究科 2018/04〜2019/03
薬学研究実験Ⅱ Research in Pharmaceutical Sciences II 後期前期 薬学研究科 2018/04〜2019/03
薬学研究実験Ⅱ Research in Pharmaceutical Sciences II 通年不定 薬学研究科 2018/04〜2019/03
薬学研究実験Ⅰ Research in Pharmaceutical Sciences I 後期前期 薬学研究科 2018/04〜2019/03
薬学研究実験Ⅰ Research in Pharmaceutical Sciences I 通年不定 薬学研究科 2018/04〜2019/03
薬局方・薬事関連法規 Pharmacopoeia ; Pharmaceutical Laws 前期 薬学部 2018/04〜2019/03
薬物動態学 Biopharmaceutics 後期 工学研究科 2018/04〜2019/03
薬物動態学(LIMS) Biopharmaceutics (LIMS) 後期集中 医学研究科 2018/04〜2019/03

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部局運営(役職等)
役職名 期間
図書委員会委員 2017/04/01〜
環境・安全衛生委員会委員 2017/04/01〜