三野享史

最終更新日時: 2021/02/01 17:04:10

氏名(漢字／フリガナ／アルファベット表記)

三野享史／ミノタカシ／Mino, Takashi

所属部署・職名(部局／所属／講座等／職名)

医学研究科／医学専攻分子生体統御学講座医化学／助教

協力講座

部局	所属	講座等	職名
医学研究科	医学専攻	感染防御生物学	助教
医学研究科	医科学専攻	感染防御生物学	助教

学部兼担

部局	所属	講座等	職名
医学部

取得学位

学位名(日本語)	学位名(英語)	大学(日本語)	大学(英語)	取得区分
修士（工学）	Master of Engineering	京都大学	Kyoto University
博士（工学）	Ph.D. in Engineering	京都大学	Kyoto University

プロフィール

(日本語)
自然免疫による炎症の制御メカニズムについて研究を行っている。特に，炎症の転写後調節のメカニズムについて研究を進めている。
(英語)
I am studying the regulatory mechanisms of innate immunity. Particularly, I am interested in the posttranscriptional regulation of innate immune system.

researchmap URL

https://researchmap.jp/7000009274

研究テーマ

(日本語)
自然免疫における転写後調節の解明
(英語)
Post-transcriptional Regulation of Innate Immune System

研究概要

(日本語)
病原体が体内に侵入すると最初に自然免疫担当細胞が病原体を検出し，炎症性サイトカイン産生を介して自然免疫応答である炎症が誘導される。これまで，サイトカイン産生(サイトカインタンパク質の翻訳)はそのmRNAの転写により調節されると考えられてきた。しかし，転写されたmRNAの安定性やタンパク質への翻訳は転写後調節と呼ばれる制御機構により細胞内で厳密に制御されており，転写後調節は自然免疫応答である炎症の開始と抑制(終焉)にも重要な役割を担っていることが明らかになってきた。我々は，これまで転写制御(mRNA産生の制御)と比較して未知の領域である，自然免疫の転写後調節について研究している。
(英語)
Cytokines are critical mediators of inflammation and host defense. Cytokine production is regulated during transcription and post-transcription. Post-transcriptional regulation modifies mRNA stability and translation, allowing for the rapid and flexible control of gene expression, which is important for coordinating the initiation and resolution of inflammation. We investigate mechanisms of post-transcriptional regulation that regulate inflammation.

研究分野（キーワード）

キーワード(日本語)	キーワード(英語)
自然免疫	Innate immune system
転写後調節	Post-transcriptional regulation
サイトカインmRNA	Cytokine mRNA
Regnase-1 (regulatory RNase-1), Zc3h12a, Mcpip1	Regnase-1 (regulatory RNase-1), Zc3h12a, Mcpip1

論文

著者	著者(日本語)	著者(英語)	タイトル	タイトル(日本語)	タイトル(英語)	書誌情報等	書誌情報等(日本語)	書誌情報等(英語)	出版年月	査読の有無	記述言語	掲載種別	公開
Yoshinari Nakatsuka, Ai Yaku, Tomohiro Handa, Alexis Vandenbon, Yuki Hikichi, Yasutaka Motomura, Ayuko Sato, Masanori Yoshinaga, Kiminobu Tanizawa, Kizuku Watanabe, Toyohiro Hirai, Kazuo Chin, Yutaka Suzuki, Takuya Uehata, Takashi Mino, Tohru Tsujimura, Kazuyo Moro, Osamu Takeuchi	Yoshinari Nakatsuka, Ai Yaku, Tomohiro Handa, Alexis Vandenbon, Yuki Hikichi, Yasutaka Motomura, Ayuko Sato, Masanori Yoshinaga, Kiminobu Tanizawa, Kizuku Watanabe, Toyohiro Hirai, Kazuo Chin, Yutaka Suzuki, Takuya Uehata, Takashi Mino, Tohru Tsujimura, Kazuyo Moro, Osamu Takeuchi	Yoshinari Nakatsuka, Ai Yaku, Tomohiro Handa, Alexis Vandenbon, Yuki Hikichi, Yasutaka Motomura, Ayuko Sato, Masanori Yoshinaga, Kiminobu Tanizawa, Kizuku Watanabe, Toyohiro Hirai, Kazuo Chin, Yutaka Suzuki, Takuya Uehata, Takashi Mino, Tohru Tsujimura, Kazuyo Moro, Osamu Takeuchi	Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by Regnase-1	Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by Regnase-1	Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by Regnase-1	European Respiratory Journal, 2000018-2000018	European Respiratory Journal, 2000018-2000018	European Respiratory Journal, 2000018-2000018	2020/09/25	有	英語	研究論文(学術雑誌)	公開
Daichi Yamasoba, Kei Sato, Takuya Ichinose, Tomoko Imamura, Lennart Koepke, Simone Joas, Elisabeth Reith, Dominik Hotter, Naoko Misawa, Kotaro Akaki, Takuya Uehata, Takashi Mino, Sho Miyamoto, Takeshi Noda, Akio Yamashita, Daron M. Standley, Frank Kirchhoff, Daniel Sauter, Yoshio Koyanagi, Osamu Takeuchi	Daichi Yamasoba, Kei Sato, Takuya Ichinose, Tomoko Imamura, Lennart Koepke, Simone Joas, Elisabeth Reith, Dominik Hotter, Naoko Misawa, Kotaro Akaki, Takuya Uehata, Takashi Mino, Sho Miyamoto, Takeshi Noda, Akio Yamashita, Daron M. Standley, Frank Kirchhoff, Daniel Sauter, Yoshio Koyanagi, Osamu Takeuchi	Daichi Yamasoba, Kei Sato, Takuya Ichinose, Tomoko Imamura, Lennart Koepke, Simone Joas, Elisabeth Reith, Dominik Hotter, Naoko Misawa, Kotaro Akaki, Takuya Uehata, Takashi Mino, Sho Miyamoto, Takeshi Noda, Akio Yamashita, Daron M. Standley, Frank Kirchhoff, Daniel Sauter, Yoshio Koyanagi, Osamu Takeuchi	N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation	N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation	N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation	Nature Microbiology, 4, 9, 1532-1544	Nature Microbiology, 4, 9, 1532-1544	Nature Microbiology, 4, 9, 1532-1544	2019/09	有	英語	研究論文(学術雑誌)	公開
Takashi Mino, Noriki Iwai, Masayuki Endo, Kentaro Inoue, Kotaro Akaki, Fabian Hia, Takuya Uehata, Tomoko Emura, Kumi Hidaka, Yutaka Suzuki, Daron M Standley, Mariko Okada-Hatakeyama, Shigeo Ohno, Hiroshi Sugiyama, Akio Yamashita, Osamu Takeuchi	Takashi Mino, Noriki Iwai, Masayuki Endo, Kentaro Inoue, Kotaro Akaki, Fabian Hia, Takuya Uehata, Tomoko Emura, Kumi Hidaka, Yutaka Suzuki, Daron M Standley, Mariko Okada-Hatakeyama, Shigeo Ohno, Hiroshi Sugiyama, Akio Yamashita, Osamu Takeuchi	Takashi Mino, Noriki Iwai, Masayuki Endo, Kentaro Inoue, Kotaro Akaki, Fabian Hia, Takuya Uehata, Tomoko Emura, Kumi Hidaka, Yutaka Suzuki, Daron M Standley, Mariko Okada-Hatakeyama, Shigeo Ohno, Hiroshi Sugiyama, Akio Yamashita, Osamu Takeuchi	Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs	Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs	Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs	Nucleic Acids Research, 47(16), 8838-8859	Nucleic Acids Research, 47(16), 8838-8859	Nucleic Acids Research, 47(16), 8838-8859	2019/07/22	有	英語	研究論文(学術雑誌)	公開
Yoshinari Nakatsuka, Alexis Vandenbon, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Xiaotong Cui, Ayuko Sato, Tohru Tsujimura, Yutaka Suzuki, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Teiji Sawa, Toyohiro Hirai, Osamu Takeuchi	Yoshinari Nakatsuka, Alexis Vandenbon, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Xiaotong Cui, Ayuko Sato, Tohru Tsujimura, Yutaka Suzuki, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Teiji Sawa, Toyohiro Hirai, Osamu Takeuchi	Yoshinari Nakatsuka, Alexis Vandenbon, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Xiaotong Cui, Ayuko Sato, Tohru Tsujimura, Yutaka Suzuki, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Teiji Sawa, Toyohiro Hirai, Osamu Takeuchi	Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia.	Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia.	Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia.	Mucosal immunology, 11, 4, 1203-1218	Mucosal immunology, 11, 4, 1203-1218	Mucosal immunology, 11, 4, 1203-1218	2018/07	有	英語	研究論文(学術雑誌)	公開
Takashi Mino, Osamu Takeuchi	Takashi Mino, Osamu Takeuchi	Takashi Mino, Osamu Takeuchi	Post-transcriptional regulation of immune responses by RNA binding proteins	Post-transcriptional regulation of immune responses by RNA binding proteins	Post-transcriptional regulation of immune responses by RNA binding proteins	Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 94, 6, 248-258	Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 94, 6, 248-258	Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 94, 6, 248-258	2018	有	英語	研究論文(大学、研究機関等紀要)	公開
Takashi Mino, Osamu Takeuchi	Takashi Mino, Osamu Takeuchi	Takashi Mino, Osamu Takeuchi	NSD3 keeps IRF3 active	NSD3 keeps IRF3 active	NSD3 keeps IRF3 active	JOURNAL OF EXPERIMENTAL MEDICINE, 214, 12, 3475-3476	JOURNAL OF EXPERIMENTAL MEDICINE, 214, 12, 3475-3476	JOURNAL OF EXPERIMENTAL MEDICINE, 214, 12, 3475-3476	2017/12	有	英語	研究論文(学術雑誌)	公開
Xiaotong Cui, Takashi Mino, Masanori Yoshinaga, Yoshinari Nakatsuka, Fabian Hia, Daichi Yamasoba, Tohru Tsujimura, Keizo Tomonaga, Yutaka Suzuki, Takuya Uehata, Osamu Takeuchi	Xiaotong Cui, Takashi Mino, Masanori Yoshinaga, Yoshinari Nakatsuka, Fabian Hia, Daichi Yamasoba, Tohru Tsujimura, Keizo Tomonaga, Yutaka Suzuki, Takuya Uehata, Osamu Takeuchi	Xiaotong Cui, Takashi Mino, Masanori Yoshinaga, Yoshinari Nakatsuka, Fabian Hia, Daichi Yamasoba, Tohru Tsujimura, Keizo Tomonaga, Yutaka Suzuki, Takuya Uehata, Osamu Takeuchi	Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis	Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis	Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis	JOURNAL OF IMMUNOLOGY, 199, 12, 4066-4077	JOURNAL OF IMMUNOLOGY, 199, 12, 4066-4077	JOURNAL OF IMMUNOLOGY, 199, 12, 4066-4077	2017/12	有	英語	研究論文(学術雑誌)	公開
Masanori Yoshinaga, Yoshinari Nakatsuka, Alexis Vandenbon, Daisuke Ori, Takuya Uehata, Tohru Tsujimura, Yutaka Suzuki, Takashi Mino, Osamu Takeuchi	Masanori Yoshinaga, Yoshinari Nakatsuka, Alexis Vandenbon, Daisuke Ori, Takuya Uehata, Tohru Tsujimura, Yutaka Suzuki, Takashi Mino, Osamu Takeuchi	Masanori Yoshinaga, Yoshinari Nakatsuka, Alexis Vandenbon, Daisuke Ori, Takuya Uehata, Tohru Tsujimura, Yutaka Suzuki, Takashi Mino, Osamu Takeuchi	Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase- Domain-Containing Protein 3 mRNAs	Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase- Domain-Containing Protein 3 mRNAs	Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase- Domain-Containing Protein 3 mRNAs	CELL REPORTS, 19, 8, 1614-1630	CELL REPORTS, 19, 8, 1614-1630	CELL REPORTS, 19, 8, 1614-1630	2017/05	有	英語	研究論文(学術雑誌)	公開
Takashi Mino, Osamu Takeuchi	Takashi Mino, Osamu Takeuchi	Takashi Mino, Osamu Takeuchi	Post-transcriptional regulation of inflammatory mRNA by Regnase-1 and Roquin	Post-transcriptional regulation of inflammatory mRNA by Regnase-1 and Roquin	Post-transcriptional regulation of inflammatory mRNA by Regnase-1 and Roquin	Folia Pharmacologica Japonica, 147, 6, 351-356	Folia Pharmacologica Japonica, 147, 6, 351-356	Folia Pharmacologica Japonica, 147, 6, 351-356	2016	有			公開
Sarang Tartey, Kazufumi Matsushita, Tomoko Imamura, Atsuko Wakabayashi, Daisuke Ori, Takashi Mino, Osamu Takeuchi	Sarang Tartey, Kazufumi Matsushita, Tomoko Imamura, Atsuko Wakabayashi, Daisuke Ori, Takashi Mino, Osamu Takeuchi	Sarang Tartey, Kazufumi Matsushita, Tomoko Imamura, Atsuko Wakabayashi, Daisuke Ori, Takashi Mino, Osamu Takeuchi	Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses	Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses	Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses	JOURNAL OF IMMUNOLOGY, 195, 2, 519-527	JOURNAL OF IMMUNOLOGY, 195, 2, 519-527	JOURNAL OF IMMUNOLOGY, 195, 2, 519-527	2015/07	有	英語	研究論文(学術雑誌)	公開
Takashi Mino, Osamu Takeuchi	Takashi Mino, Osamu Takeuchi	Takashi Mino, Osamu Takeuchi	Regnase-1 and Roquin regulate inflammatory mRNAs	Regnase-1 and Roquin regulate inflammatory mRNAs	Regnase-1 and Roquin regulate inflammatory mRNAs	ONCOTARGET, 6, 20, 17869-17870	ONCOTARGET, 6, 20, 17869-17870	ONCOTARGET, 6, 20, 17869-17870	2015/07	有	英語	研究論文(学術雑誌)	公開
Takashi Mino, Yasuhiro Murakawa, Akira Fukao, Alexis Vandenbon, Hans-Hermann Wessels, Daisuke Ori, Takuya Uehata, Sarang Tartey, Shizuo Akira, Yutaka Suzuki, Carola G. Vinuesa, Uwe Ohler, Daron M. Standley, Markus Landthaler, Toshinobu Fujiwara, Osamu Takeuchi	Takashi Mino, Yasuhiro Murakawa, Akira Fukao, Alexis Vandenbon, Hans-Hermann Wessels, Daisuke Ori, Takuya Uehata, Sarang Tartey, Shizuo Akira, Yutaka Suzuki, Carola G. Vinuesa, Uwe Ohler, Daron M. Standley, Markus Landthaler, Toshinobu Fujiwara, Osamu Takeuchi	Takashi Mino, Yasuhiro Murakawa, Akira Fukao, Alexis Vandenbon, Hans-Hermann Wessels, Daisuke Ori, Takuya Uehata, Sarang Tartey, Shizuo Akira, Yutaka Suzuki, Carola G. Vinuesa, Uwe Ohler, Daron M. Standley, Markus Landthaler, Toshinobu Fujiwara, Osamu Takeuchi	Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms	Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms	Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms	CELL, 161, 5, 1058-1073	CELL, 161, 5, 1058-1073	CELL, 161, 5, 1058-1073	2015/05	有	英語	研究論文(学術雑誌)	公開
Tartey S, Matsushita K, Vandenbon A, Ori D, Imamura T, Mino T, Standley DM, Hoffmann JA, Reichhart JM, Akira S, Takeuchi O	Tartey S, Matsushita K, Vandenbon A, Ori D, Imamura T, Mino T, Standley DM, Hoffmann JA, Reichhart JM, Akira S, Takeuchi O	Sarang Tartey, Kazufumi Matsushita, Alexis Vandenbon, Daisuke Ori, Tomoko Imamura, Takashi Mino, Daron M. Standley, Jules A. Hoffmann, Jean-Marc Reichhart, Shizuo Akira, Osamu Takeuchi	Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex.	Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex.	Akirin2 is critical for inducing inflammatory genes by bridging I kappa B-zeta and the SWI/SNF complex	The EMBO journal, 33, 20, 2332-2348	The EMBO journal, 33, 20, 2332-2348	EMBO JOURNAL, 33, 20, 2332-2348	2014/10	有	英語	研究論文(学術雑誌)	公開
Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera	Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera	Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera	Inhibition of DNA Replication of Human Papillomavirus by Using Zinc Finger-Single-Chain FokI Dimer Hybrid	Inhibition of DNA Replication of Human Papillomavirus by Using Zinc Finger-Single-Chain FokI Dimer Hybrid	Inhibition of DNA Replication of Human Papillomavirus by Using Zinc Finger-Single-Chain FokI Dimer Hybrid	MOLECULAR BIOTECHNOLOGY, 56, 8, 731-737	MOLECULAR BIOTECHNOLOGY, 56, 8, 731-737	MOLECULAR BIOTECHNOLOGY, 56, 8, 731-737	2014/08	有	英語	研究論文(学術雑誌)	公開
Kazuya Masuda, Barry Ripley, Riko Nishimura, Takashi Mino, Osamu Takeuchi, Go Shioi, Hiroshi Kiyonari, Tadamitsu Kishimoto	Kazuya Masuda, Barry Ripley, Riko Nishimura, Takashi Mino, Osamu Takeuchi, Go Shioi, Hiroshi Kiyonari, Tadamitsu Kishimoto	Kazuya Masuda, Barry Ripley, Riko Nishimura, Takashi Mino, Osamu Takeuchi, Go Shioi, Hiroshi Kiyonari, Tadamitsu Kishimoto	Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo	Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo	Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo	Proceedings of the National Academy of Sciences of the United States of America, 110, 23, 9409-9414	Proceedings of the National Academy of Sciences of the United States of America, 110, 23, 9409-9414	Proceedings of the National Academy of Sciences of the United States of America, 110, 23, 9409-9414	2013/06/04	有	英語	研究論文(学術雑誌)	公開
Masahiro Fukasaka, Daisuke Ori, Tatsukata Kawagoe, Satoshi Uematsu, Kenta Maruyama, Toshihiko Okazaki, Tatsuya Kozaki, Tomoko Imamura, Sarang Tartey, Takashi Mino, Takashi Satoh, Shizuo Akira, Osamu Takeuchi	Masahiro Fukasaka, Daisuke Ori, Tatsukata Kawagoe, Satoshi Uematsu, Kenta Maruyama, Toshihiko Okazaki, Tatsuya Kozaki, Tomoko Imamura, Sarang Tartey, Takashi Mino, Takashi Satoh, Shizuo Akira, Osamu Takeuchi	Masahiro Fukasaka, Daisuke Ori, Tatsukata Kawagoe, Satoshi Uematsu, Kenta Maruyama, Toshihiko Okazaki, Tatsuya Kozaki, Tomoko Imamura, Sarang Tartey, Takashi Mino, Takashi Satoh, Shizuo Akira, Osamu Takeuchi	Critical Role of AZI2 in GM-CSF-Induced Dendritic Cell Differentiation	Critical Role of AZI2 in GM-CSF-Induced Dendritic Cell Differentiation	Critical Role of AZI2 in GM-CSF-Induced Dendritic Cell Differentiation	JOURNAL OF IMMUNOLOGY, 190, 11, 5702-5711	JOURNAL OF IMMUNOLOGY, 190, 11, 5702-5711	JOURNAL OF IMMUNOLOGY, 190, 11, 5702-5711	2013/06	有	英語	研究論文(学術雑誌)	公開
Takuya Uehata, Hidenori Iwasaki, Alexis Vandenbon, Kazufumi Matsushita, Eduardo Hernandez-Cuellar, Kanako Kuniyoshi, Takashi Satoh, Takashi Mino, Yutaka Suzuki, Daron M Standley, Tohru Tsujimura, Hiromi Rakugi, Yoshitaka Isaka, Osamu Takeuchi, Shizuo Akira	Takuya Uehata, Hidenori Iwasaki, Alexis Vandenbon, Kazufumi Matsushita, Eduardo Hernandez-Cuellar, Kanako Kuniyoshi, Takashi Satoh, Takashi Mino, Yutaka Suzuki, Daron M Standley, Tohru Tsujimura, Hiromi Rakugi, Yoshitaka Isaka, Osamu Takeuchi, Shizuo Akira	Takuya Uehata, Hidenori Iwasaki, Alexis Vandenbon, Kazufumi Matsushita, Eduardo Hernandez-Cuellar, Kanako Kuniyoshi, Takashi Satoh, Takashi Mino, Yutaka Suzuki, Daron M Standley, Tohru Tsujimura, Hiromi Rakugi, Yoshitaka Isaka, Osamu Takeuchi, Shizuo Akira	Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation.	Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation.	Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation.	Cell, 153, 5, 1036-49	Cell, 153, 5, 1036-49	Cell, 153, 5, 1036-49	2013/05/23	有	英語	研究論文(学術雑誌)	公開
Daisuke Ori, Hiroki Kato, Hideki Sanjo, Sarang Tartey, Takashi Mino, Shizuo Akira, Osamu Takeuchi	Daisuke Ori, Hiroki Kato, Hideki Sanjo, Sarang Tartey, Takashi Mino, Shizuo Akira, Osamu Takeuchi	Daisuke Ori, Hiroki Kato, Hideki Sanjo, Sarang Tartey, Takashi Mino, Shizuo Akira, Osamu Takeuchi	Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs	Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs	Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs	JOURNAL OF IMMUNOLOGY, 190, 8, 4037-4045	JOURNAL OF IMMUNOLOGY, 190, 8, 4037-4045	JOURNAL OF IMMUNOLOGY, 190, 8, 4037-4045	2013/04	有	英語	研究論文(学術雑誌)	公開
Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera	Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera	Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera	Gene- and Protein-Delivered Zinc Finger-Staphylococcal Nuclease Hybrid for Inhibition of DNA Replication of Human Papillomavirus	Gene- and Protein-Delivered Zinc Finger-Staphylococcal Nuclease Hybrid for Inhibition of DNA Replication of Human Papillomavirus	Gene- and Protein-Delivered Zinc Finger-Staphylococcal Nuclease Hybrid for Inhibition of DNA Replication of Human Papillomavirus	PLOS ONE, 8, 2, e56633	PLOS ONE, 8, 2, e56633	PLOS ONE, 8, 2, e56633	2013/02	有	英語	研究論文(学術雑誌)	公開
Takashi Mino, Osamu Takeuchi	Takashi Mino, Osamu Takeuchi	Takashi Mino, Osamu Takeuchi	Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation	Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation	Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation	BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, VOL 29, ISSUE1, 29, 1, 49-60	BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, VOL 29, ISSUE1, 29, 1, 49-60	BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, VOL 29, ISSUE1, 29, 1, 49-60	2013	有	英語		公開
三野享史, 竹内理	三野享史, 竹内理		シグナル自然免疫における転写後調節	シグナル自然免疫における転写後調節		医学のあゆみ, 243, 1, 57-62	医学のあゆみ, 243, 1, 57-62	, 243, 1, 57-62	2012/10/06	有	日本語		公開
Ping-Hui Tseng, Atsushi Matsuzawa, Weizhou Zhang, Takashi Mino, Dario A. A. Vignali, Michael Karin	Ping-Hui Tseng, Atsushi Matsuzawa, Weizhou Zhang, Takashi Mino, Dario A. A. Vignali, Michael Karin	Ping-Hui Tseng, Atsushi Matsuzawa, Weizhou Zhang, Takashi Mino, Dario A. A. Vignali, Michael Karin	Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines	Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines	Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines	NATURE IMMUNOLOGY, 11, 1, 70-1819	NATURE IMMUNOLOGY, 11, 1, 70-1819	NATURE IMMUNOLOGY, 11, 1, 70-1819	2010/01	有	英語	研究論文(学術雑誌)	公開
Takashi Mino, Yasuhiro Aoyama, Takashi Sera	Takashi Mino, Yasuhiro Aoyama, Takashi Sera	Takashi Mino, Yasuhiro Aoyama, Takashi Sera	Efficient double-stranded DNA cleavage by artificial zinc-finger nucleases composed of one zinc-finger protein and a single-chain FokI dimer	Efficient double-stranded DNA cleavage by artificial zinc-finger nucleases composed of one zinc-finger protein and a single-chain FokI dimer	Efficient double-stranded DNA cleavage by artificial zinc-finger nucleases composed of one zinc-finger protein and a single-chain FokI dimer	JOURNAL OF BIOTECHNOLOGY, 140, 3-4, 156-161	JOURNAL OF BIOTECHNOLOGY, 140, 3-4, 156-161	JOURNAL OF BIOTECHNOLOGY, 140, 3-4, 156-161	2009/03	有	英語	研究論文(学術雑誌)	公開
Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera	Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera	Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera	Cell-permeable artificial zinc-finger proteins as potent antiviral drugs for human papillomaviruses	Cell-permeable artificial zinc-finger proteins as potent antiviral drugs for human papillomaviruses	Cell-permeable artificial zinc-finger proteins as potent antiviral drugs for human papillomaviruses	ARCHIVES OF VIROLOGY, 153, 7, 1291-1298	ARCHIVES OF VIROLOGY, 153, 7, 1291-1298	ARCHIVES OF VIROLOGY, 153, 7, 1291-1298	2008/07	有	英語	研究論文(学術雑誌)	公開
T. Mino, T. Mori, Y. Aoyama, T. Sera	T. Mino, T. Mori, Y. Aoyama, T. Sera	T. Mino, T. Mori, Y. Aoyama, T. Sera	Inhibition of human papillomavirus replication by using artificial zinc-finger nucleases.	Inhibition of human papillomavirus replication by using artificial zinc-finger nucleases.	Inhibition of human papillomavirus replication by using artificial zinc-finger nucleases.	Nucleic acids symposium series, 52, 185-186	Nucleic acids symposium series, 52, 185-186	Nucleic acids symposium series, 52, 185-186	2008	有	英語		公開
T. Mino, T. Mori, Y. Aoyama, T. Sera	T. Mino, T. Mori, Y. Aoyama, T. Sera	T. Mino, T. Mori, Y. Aoyama, T. Sera	Development of protein-based antiviral drugs for human papillomaviruses.	Development of protein-based antiviral drugs for human papillomaviruses.	Development of protein-based antiviral drugs for human papillomaviruses.	Nucleic acids symposium series, 51, 427-428	Nucleic acids symposium series, 51, 427-428	Nucleic acids symposium series, 51, 427-428	2007	有	英語		公開
T Mino, T Hatono, N Matsumoto, T Mori, Y Mineta, Y Aoyama, T Sera	T Mino, T Hatono, N Matsumoto, T Mori, Y Mineta, Y Aoyama, T Sera	T Mino, T Hatono, N Matsumoto, T Mori, Y Mineta, Y Aoyama, T Sera	Inhibition of DNA replication of human papillomavirus by artificial zinc finger proteins	Inhibition of DNA replication of human papillomavirus by artificial zinc finger proteins	Inhibition of DNA replication of human papillomavirus by artificial zinc finger proteins	JOURNAL OF VIROLOGY, 80, 11, 5405-5412	JOURNAL OF VIROLOGY, 80, 11, 5405-5412	JOURNAL OF VIROLOGY, 80, 11, 5405-5412	2006/06	有	英語	研究論文(学術雑誌)	公開
Mino T, Mori T, Matsumoto N, Mineta Y, Okamoto T, Aoyama Y, Sera T		Mino T, Mori T, Matsumoto N, Mineta Y, Okamoto T, Aoyama Y, Sera T	Application of artificial zinc-finger proteins to inhibition of DNA replication of human papillomavirus.	Application of artificial zinc-finger proteins to inhibition of DNA replication of human papillomavirus.	Application of artificial zinc-finger proteins to inhibition of DNA replication of human papillomavirus.	Nucleic Acids Symposium Series, 50, 313-314	Nucleic Acids Symposium Series, 50, 313-314	Nucleic Acids Symposium Series, 50, 313-314	2006	有	英語		公開
<< < > >> 表示タイトル言語:

Misc

著者	著者(日本語)	著者(英語)	タイトル	タイトル(日本語)	タイトル(英語)	書誌情報等	書誌情報等(日本語)	書誌情報等(英語)	出版年月	記述言語	掲載種別	公開
Yoshinari Nakatsuka, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Toyohiro Hirai Hirai, Osamu Takeuchi	Yoshinari Nakatsuka, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Toyohiro Hirai Hirai, Osamu Takeuchi	Yoshinari Nakatsuka, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Toyohiro Hirai Hirai, Osamu Takeuchi	Pulmonary Regnase-1 functions as a posttranscriptional switch in anti-bacterial immunity	Pulmonary Regnase-1 functions as a posttranscriptional switch in anti-bacterial immunity	Pulmonary Regnase-1 functions as a posttranscriptional switch in anti-bacterial immunity	CYTOKINE, 100, 39-39	CYTOKINE, 100, 39-39	CYTOKINE, 100, 39-39	2017/12	英語	研究発表ペーパー要旨(国際会議)	公開
Kazuya Masuda, Barry Ripley, Riko Nishimura, Takashi Mino, Osamu Takeuchi, Go Shioi, Hiroshi Kiyonari, Tadamitsu Kishimoto	Kazuya Masuda, Barry Ripley, Riko Nishimura, Takashi Mino, Osamu Takeuchi, Go Shioi, Hiroshi Kiyonari, Tadamitsu Kishimoto	Kazuya Masuda, Barry Ripley, Riko Nishimura, Takashi Mino, Osamu Takeuchi, Go Shioi, Hiroshi Kiyonari, Tadamitsu Kishimoto	Arid5a contributes to stabilization of IL-6 mRNA, and elevation of IL-6 level in vivo	Arid5a contributes to stabilization of IL-6 mRNA, and elevation of IL-6 level in vivo	Arid5a contributes to stabilization of IL-6 mRNA, and elevation of IL-6 level in vivo	CYTOKINE, 63, 3, 284-284	CYTOKINE, 63, 3, 284-284	CYTOKINE, 63, 3, 284-284	2013/09	英語	研究発表ペーパー要旨(国際会議)	公開
タイトル言語:

産業財産権 (特許)

発明者	発明者(日本語)	発明者(英語)	発明の名称	発明の名称(日本語)	発明の名称(英語)	審査の段階	番号	年月	公開
竹内理, 三野享史, 山下暁朗	竹内理, 三野享史, 山下暁朗		免疫賦活化剤	免疫賦活化剤	IMMUNOSTIMULANTS	特許公開	特開2019-073466		公開
タイトル言語:

外部資金：競争的資金 (科学研究費補助金)

種別	代表/分担	テーマ(日本語)	期間
若手研究（Ｂ）	代表	Regnase-1の作用機構から探る自然免疫応答における転写後調節の解明	2013〜2014
若手研究（Ｂ）	代表	Regnase-1の作用機構から探る自然免疫応答における転写後調節の解明（平成26年度分）	2014/04/01〜2015/03/31
基盤研究(C)	代表	UPF1の作用機構から探る自然免疫における転写後制御機構の解明（平成28年度分）	2016/04/01〜2017/03/31
基盤研究(C)	代表	UPF1の作用機構から探る自然免疫における転写後制御機構の解明（平成29年度分）	2017/04/01〜2018/03/31
基盤研究(C)	代表	UPF1の作用機構から探る自然免疫における転写後制御機構の解明（平成30年度分）	2018/04/01〜2019/03/31
基盤研究(B)	代表	免疫システムにおけるmRNAの翻訳制御機構の解明	2019/04/01〜2022/03/31
基盤研究(B)	代表	免疫システムにおけるmRNAの翻訳制御機構の解明（2019年度分）	2019/04/01〜2020/03/31

担当科目

講義名(日本語)	講義名(英語)	開講期	学部/研究科	年度
ILASセミナー	ILAS Seminar	前期	全学共通科目	2016/04〜2017/03

部局運営（役職等）

役職名	期間
共同利用機器等委員会　委員	2014/04/01〜2017/03/31
化学物質管理委員会　委員	2013/04/01〜2017/03/31
（旧ウイルス研）共同利用機器等委員会　委員	2016/10/01〜
化学物質管理委員会　委員	2016/10/01〜
共同利用機器等委員会	2018/04/01〜

三野 享史

三野享史