遊佐 宏介

最終更新日時: 2019/09/30 12:23:18

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氏名(漢字/フリガナ/アルファベット表記)
遊佐 宏介/ユサ コウスケ/Yusa, Kosuke
所属部署・職名(部局/所属/講座等/職名)
ウイルス・再生医科学研究所/生命システム研究部門/教授
協力講座
部局 所属 講座等 職名
医学研究科 医学専攻 幹細胞遺伝学 教授
医学研究科 医科学専攻 幹細胞遺伝学 教授
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士(農学) 東京大学
博士(医学) 大阪大学
researchmap URL
https://researchmap.jp/7000025204
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Yu JSL, Yusa K Yu JSL, Yusa K Yu JSL, Yusa K Genome-wide CRISPR-Cas9 screening in mammalian cells. Genome-wide CRISPR-Cas9 screening in mammalian cells. Genome-wide CRISPR-Cas9 screening in mammalian cells. Methods (San Diego, Calif.), 164-165, 29-35 Methods (San Diego, Calif.), 164-165, 29-35 Methods (San Diego, Calif.), 164-165, 29-35 2019/07 公開
Yu JSL, Palano G, Lim C, Moggio A, Drowley L, Plowright AT, Bohlooly-Y M, Rosen BS, Hansson EM, Wang QD, Yusa K Yu JSL, Palano G, Lim C, Moggio A, Drowley L, Plowright AT, Bohlooly-Y M, Rosen BS, Hansson EM, Wang QD, Yusa K Yu JSL, Palano G, Lim C, Moggio A, Drowley L, Plowright AT, Bohlooly-Y M, Rosen BS, Hansson EM, Wang QD, Yusa K CRISPR-Knockout Screen Identifies Dmap1 as a Regulator of Chemically Induced Reprogramming and Differentiation of Cardiac Progenitors. CRISPR-Knockout Screen Identifies Dmap1 as a Regulator of Chemically Induced Reprogramming and Differentiation of Cardiac Progenitors. CRISPR-Knockout Screen Identifies Dmap1 as a Regulator of Chemically Induced Reprogramming and Differentiation of Cardiac Progenitors. Stem cells (Dayton, Ohio), 37, 7, 958-972 Stem cells (Dayton, Ohio), 37, 7, 958-972 Stem cells (Dayton, Ohio), 37, 7, 958-972 2019/07 公開
Picco G, Chen ED, Alonso LG, Behan FM, Gonçalves E, Bignell G, Matchan A, Fu B, Banerjee R, Anderson E, Butler A, Benes CH, McDermott U, Dow D, Iorio F, Stronach E, Yang F, Yusa K, Saez-Rodriguez J, Garnett MJ Picco G, Chen ED, Alonso LG, Behan FM, Gonçalves E, Bignell G, Matchan A, Fu B, Banerjee R, Anderson E, Butler A, Benes CH, McDermott U, Dow D, Iorio F, Stronach E, Yang F, Yusa K, Saez-Rodriguez J, Garnett MJ Picco G, Chen ED, Alonso LG, Behan FM, Gonçalves E, Bignell G, Matchan A, Fu B, Banerjee R, Anderson E, Butler A, Benes CH, McDermott U, Dow D, Iorio F, Stronach E, Yang F, Yusa K, Saez-Rodriguez J, Garnett MJ Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening. Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening. Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening. Nature communications, 10, 1, 2198 Nature communications, 10, 1, 2198 Nature communications, 10, 1, 2198 2019/05 公開
Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens. Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens. Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens. Nature, 568, 7753, 511-516 Nature, 568, 7753, 511-516 Nature, 568, 7753, 511-516 2019/04 公開
Allen F, Behan F, Khodak A, Iorio F, Yusa K, Garnett M, Parts L Allen F, Behan F, Khodak A, Iorio F, Yusa K, Garnett M, Parts L Allen F, Behan F, Khodak A, Iorio F, Yusa K, Garnett M, Parts L JACKS: joint analysis of CRISPR/Cas9 knockout screens. JACKS: joint analysis of CRISPR/Cas9 knockout screens. JACKS: joint analysis of CRISPR/Cas9 knockout screens. Genome research, 29, 3, 464-471 Genome research, 29, 3, 464-471 Genome research, 29, 3, 464-471 2019/03 公開
Gonçalves E, Behan FM, Louzada S, Arnol D, Stronach EA, Yang F, Yusa K, Stegle O, Iorio F, Garnett MJ Gonçalves E, Behan FM, Louzada S, Arnol D, Stronach EA, Yang F, Yusa K, Stegle O, Iorio F, Garnett MJ Gonçalves E, Behan FM, Louzada S, Arnol D, Stronach EA, Yang F, Yusa K, Stegle O, Iorio F, Garnett MJ Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects. Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects. Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects. Genome biology, 20, 1, 27 Genome biology, 20, 1, 27 Genome biology, 20, 1, 27 2019/02 公開
Henriksson J, Chen X, Gomes T, Ullah U, Meyer KB, Miragaia R, Duddy G, Pramanik J, Yusa K, Lahesmaa R, Teichmann SA Henriksson J, Chen X, Gomes T, Ullah U, Meyer KB, Miragaia R, Duddy G, Pramanik J, Yusa K, Lahesmaa R, Teichmann SA Henriksson J, Chen X, Gomes T, Ullah U, Meyer KB, Miragaia R, Duddy G, Pramanik J, Yusa K, Lahesmaa R, Teichmann SA Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation. Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation. Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation. Cell, 176, 4, 882-896.e18 Cell, 176, 4, 882-896.e18 Cell, 176, 4, 882-896.e18 2019/02 公開
Balmus G, Pilger D, Coates J, Demir M, Sczaniecka-Clift M, Barros AC, Woods M, Fu B, Yang F, Chen E, Ostermaier M, Stankovic T, Ponstingl H, Herzog M, Yusa K, Martinez FM, Durant ST, Galanty Y, Beli P, Adams DJ, Bradley A, Metzakopian E, Forment JV, Jackson SP Balmus G, Pilger D, Coates J, Demir M, Sczaniecka-Clift M, Barros AC, Woods M, Fu B, Yang F, Chen E, Ostermaier M, Stankovic T, Ponstingl H, Herzog M, Yusa K, Martinez FM, Durant ST, Galanty Y, Beli P, Adams DJ, Bradley A, Metzakopian E, Forment JV, Jackson SP Balmus G, Pilger D, Coates J, Demir M, Sczaniecka-Clift M, Barros AC, Woods M, Fu B, Yang F, Chen E, Ostermaier M, Stankovic T, Ponstingl H, Herzog M, Yusa K, Martinez FM, Durant ST, Galanty Y, Beli P, Adams DJ, Bradley A, Metzakopian E, Forment JV, Jackson SP ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks. ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks. ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks. Nature communications, 10, 1, 87 Nature communications, 10, 1, 87 Nature communications, 10, 1, 87 2019/01 公開
Tzelepis K, De Braekeleer E, Aspris D, Barbieri I, Vijayabaskar MS, Liu WH, Gozdecka M, Metzakopian E, Toop HD, Dudek M, Robson SC, Hermida-Prado F, Yang YH, Babaei-Jadidi R, Garyfallos DA, Ponstingl H, Dias JML, Gallipoli P, Seiler M, Buonamici S, Vick B, Bannister AJ, Rad R, Prinjha RK, Marioni JC, Huntly B, Batson J, Morris JC, Pina C, Bradley A, Jeremias I, Bates DO, Yusa K, Kouzarides T, Vassiliou GS Tzelepis K, De Braekeleer E, Aspris D, Barbieri I, Vijayabaskar MS, Liu WH, Gozdecka M, Metzakopian E, Toop HD, Dudek M, Robson SC, Hermida-Prado F, Yang YH, Babaei-Jadidi R, Garyfallos DA, Ponstingl H, Dias JML, Gallipoli P, Seiler M, Buonamici S, Vick B, Bannister AJ, Rad R, Prinjha RK, Marioni JC, Huntly B, Batson J, Morris JC, Pina C, Bradley A, Jeremias I, Bates DO, Yusa K, Kouzarides T, Vassiliou GS Tzelepis K, De Braekeleer E, Aspris D, Barbieri I, Vijayabaskar MS, Liu WH, Gozdecka M, Metzakopian E, Toop HD, Dudek M, Robson SC, Hermida-Prado F, Yang YH, Babaei-Jadidi R, Garyfallos DA, Ponstingl H, Dias JML, Gallipoli P, Seiler M, Buonamici S, Vick B, Bannister AJ, Rad R, Prinjha RK, Marioni JC, Huntly B, Batson J, Morris JC, Pina C, Bradley A, Jeremias I, Bates DO, Yusa K, Kouzarides T, Vassiliou GS SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4. SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4. SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4. Nature communications, 9, 1, 5378 Nature communications, 9, 1, 5378 Nature communications, 9, 1, 5378 2018/12 公開
Chong ZS, Ohnishi S, Yusa K, Wright GJ Chong ZS, Ohnishi S, Yusa K, Wright GJ Chong ZS, Ohnishi S, Yusa K, Wright GJ Pooled extracellular receptor-ligand interaction screening using CRISPR activation. Pooled extracellular receptor-ligand interaction screening using CRISPR activation. Pooled extracellular receptor-ligand interaction screening using CRISPR activation. Genome biology, 19, 1, 205 Genome biology, 19, 1, 205 Genome biology, 19, 1, 205 2018/11 公開
Sharma S, Bartholdson SJ, Couch ACM, Yusa K, Wright GJ Sharma S, Bartholdson SJ, Couch ACM, Yusa K, Wright GJ Sharma S, Bartholdson SJ, Couch ACM, Yusa K, Wright GJ Genome-scale identification of cellular pathways required for cell surface recognition. Genome-scale identification of cellular pathways required for cell surface recognition. Genome-scale identification of cellular pathways required for cell surface recognition. Genome research, 28, 9, 1372-1382 Genome research, 28, 9, 1372-1382 Genome research, 28, 9, 1372-1382 2018/09 公開
Iorio F, Behan FM, Gonçalves E, Bhosle SG, Chen E, Shepherd R, Beaver C, Ansari R, Pooley R, Wilkinson P, Harper S, Butler AP, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ Iorio F, Behan FM, Gonçalves E, Bhosle SG, Chen E, Shepherd R, Beaver C, Ansari R, Pooley R, Wilkinson P, Harper S, Butler AP, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ Iorio F, Behan FM, Gonçalves E, Bhosle SG, Chen E, Shepherd R, Beaver C, Ansari R, Pooley R, Wilkinson P, Harper S, Butler AP, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting. Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting. Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting. BMC genomics, 19, 1, 604 BMC genomics, 19, 1, 604 BMC genomics, 19, 1, 604 2018/08 公開
Li M, Yu JSL, Tilgner K, Ong SH, Koike-Yusa H, Yusa K Li M, Yu JSL, Tilgner K, Ong SH, Koike-Yusa H, Yusa K Li M, Yu JSL, Tilgner K, Ong SH, Koike-Yusa H, Yusa K Genome-wide CRISPR-KO Screen Uncovers mTORC1-Mediated Gsk3 Regulation in Naive Pluripotency Maintenance and Dissolution. Genome-wide CRISPR-KO Screen Uncovers mTORC1-Mediated Gsk3 Regulation in Naive Pluripotency Maintenance and Dissolution. Genome-wide CRISPR-KO Screen Uncovers mTORC1-Mediated Gsk3 Regulation in Naive Pluripotency Maintenance and Dissolution. Cell reports, 24, 2, 489-502 Cell reports, 24, 2, 489-502 Cell reports, 24, 2, 489-502 2018/07 公開
Fukuda K, Okuda A, Yusa K, Shinkai Y Fukuda K, Okuda A, Yusa K, Shinkai Y Fukuda K, Okuda A, Yusa K, Shinkai Y A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells. A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells. A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells. Genome research, 28, 6, 846-858 Genome research, 28, 6, 846-858 Genome research, 28, 6, 846-858 2018/06 公開
Pettitt SJ, Krastev DB, Brandsma I, Dréan A, Song F, Aleksandrov R, Harrell MI, Menon M, Brough R, Campbell J, Frankum J, Ranes M, Pemberton HN, Rafiq R, Fenwick K, Swain A, Guettler S, Lee JM, Swisher EM, Stoynov S, Yusa K, Ashworth A, Lord CJ Pettitt SJ, Krastev DB, Brandsma I, Dréan A, Song F, Aleksandrov R, Harrell MI, Menon M, Brough R, Campbell J, Frankum J, Ranes M, Pemberton HN, Rafiq R, Fenwick K, Swain A, Guettler S, Lee JM, Swisher EM, Stoynov S, Yusa K, Ashworth A, Lord CJ Pettitt SJ, Krastev DB, Brandsma I, Dréan A, Song F, Aleksandrov R, Harrell MI, Menon M, Brough R, Campbell J, Frankum J, Ranes M, Pemberton HN, Rafiq R, Fenwick K, Swain A, Guettler S, Lee JM, Swisher EM, Stoynov S, Yusa K, Ashworth A, Lord CJ Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance. Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance. Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance. Nature communications, 9, 1, 1849 Nature communications, 9, 1, 1849 Nature communications, 9, 1, 1849 2018/05 公開
Ong SH, Li Y, Koike-Yusa H, Yusa K Ong SH, Li Y, Koike-Yusa H, Yusa K Ong SH, Li Y, Koike-Yusa H, Yusa K Author Correction: Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries. Author Correction: Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries. Author Correction: Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries. Scientific reports, 8, 1, 6136 Scientific reports, 8, 1, 6136 Scientific reports, 8, 1, 6136 2018/04 公開
Ruetz T, Pfisterer U, Di Stefano B, Ashmore J, Beniazza M, Tian TV, Kaemena DF, Tosti L, Tan W, Manning JR, Chantzoura E, Ottosson DR, Collombet S, Johnsson A, Cohen E, Yusa K, Linnarsson S, Graf T, Parmar M, Kaji K Ruetz T, Pfisterer U, Di Stefano B, Ashmore J, Beniazza M, Tian TV, Kaemena DF, Tosti L, Tan W, Manning JR, Chantzoura E, Ottosson DR, Collombet S, Johnsson A, Cohen E, Yusa K, Linnarsson S, Graf T, Parmar M, Kaji K Ruetz T, Pfisterer U, Di Stefano B, Ashmore J, Beniazza M, Tian TV, Kaemena DF, Tosti L, Tan W, Manning JR, Chantzoura E, Ottosson DR, Collombet S, Johnsson A, Cohen E, Yusa K, Linnarsson S, Graf T, Parmar M, Kaji K Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming. Cell stem cell, 21, 6, 791-805.e9 Cell stem cell, 21, 6, 791-805.e9 Cell stem cell, 21, 6, 791-805.e9 2017/12 公開
Dovey OM, Cooper JL, Mupo A, Grove CS, Lynn C, Conte N, Andrews RM, Pacharne S, Tzelepis K, Vijayabaskar MS, Green P, Rad R, Arends M, Wright P, Yusa K, Bradley A, Varela I, Vassiliou GS Dovey OM, Cooper JL, Mupo A, Grove CS, Lynn C, Conte N, Andrews RM, Pacharne S, Tzelepis K, Vijayabaskar MS, Green P, Rad R, Arends M, Wright P, Yusa K, Bradley A, Varela I, Vassiliou GS Dovey OM, Cooper JL, Mupo A, Grove CS, Lynn C, Conte N, Andrews RM, Pacharne S, Tzelepis K, Vijayabaskar MS, Green P, Rad R, Arends M, Wright P, Yusa K, Bradley A, Varela I, Vassiliou GS Molecular synergy underlies the co-occurrence patterns and phenotype of <i>NPM1</i>-mutant acute myeloid leukemia. Molecular synergy underlies the co-occurrence patterns and phenotype of <i>NPM1</i>-mutant acute myeloid leukemia. Molecular synergy underlies the co-occurrence patterns and phenotype of <i>NPM1</i>-mutant acute myeloid leukemia. Blood, 130, 17, 1911-1922 Blood, 130, 17, 1911-1922 Blood, 130, 17, 1911-1922 2017/10 公開
Ong SH, Li Y, Koike-Yusa H, Yusa K Ong SH, Li Y, Koike-Yusa H, Yusa K Ong SH, Li Y, Koike-Yusa H, Yusa K Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries. Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries. Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries. Scientific reports, 7, 1, 7384 Scientific reports, 7, 1, 7384 Scientific reports, 7, 1, 7384 2017/08 公開
Lu Q, Livi GP, Modha S, Yusa K, Macarrón R, Dow DJ Lu Q, Livi GP, Modha S, Yusa K, Macarrón R, Dow DJ Lu Q, Livi GP, Modha S, Yusa K, Macarrón R, Dow DJ Applications of CRISPR genome editing technology in drug target identification and validation. Applications of CRISPR genome editing technology in drug target identification and validation. Applications of CRISPR genome editing technology in drug target identification and validation. Expert opinion on drug discovery, 12, 6, 541-552 Expert opinion on drug discovery, 12, 6, 541-552 Expert opinion on drug discovery, 12, 6, 541-552 2017/06 公開
Yamanishi A, Yusa K, Horie K, Tokunaga M, Kusano K, Kokubu C, Takeda J Yamanishi A, Yusa K, Horie K, Tokunaga M, Kusano K, Kokubu C, Takeda J Yamanishi A, Yusa K, Horie K, Tokunaga M, Kusano K, Kokubu C, Takeda J Enhancement of microhomology-mediated genomic rearrangements by transient loss of mouse Bloom syndrome helicase. Enhancement of microhomology-mediated genomic rearrangements by transient loss of mouse Bloom syndrome helicase. Enhancement of microhomology-mediated genomic rearrangements by transient loss of mouse Bloom syndrome helicase. Genome research, 23, 9, 1462-1473 Genome research, 23, 9, 1462-1473 Genome research, 23, 9, 1462-1473 2013/09 公開
Rad R, Cadiñanos J, Rad L, Varela I, Strong A, Kriegl L, Constantino-Casas F, Eser S, Hieber M, Seidler B, Price S, Fraga MF, Calvanese V, Hoffman G, Ponstingl H, Schneider G, Yusa K, Grove C, Schmid RM, Wang W, Vassiliou G, Kirchner T, McDermott U, Liu P, Saur D, Bradley A Rad R, Cadiñanos J, Rad L, Varela I, Strong A, Kriegl L, Constantino-Casas F, Eser S, Hieber M, Seidler B, Price S, Fraga MF, Calvanese V, Hoffman G, Ponstingl H, Schneider G, Yusa K, Grove C, Schmid RM, Wang W, Vassiliou G, Kirchner T, McDermott U, Liu P, Saur D, Bradley A Rad R, Cadiñanos J, Rad L, Varela I, Strong A, Kriegl L, Constantino-Casas F, Eser S, Hieber M, Seidler B, Price S, Fraga MF, Calvanese V, Hoffman G, Ponstingl H, Schneider G, Yusa K, Grove C, Schmid RM, Wang W, Vassiliou G, Kirchner T, McDermott U, Liu P, Saur D, Bradley A A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention. A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention. A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention. Cancer cell, 24, 1, 15-29 Cancer cell, 24, 1, 15-29 Cancer cell, 24, 1, 15-29 2013/07 公開
Li MA, Pettitt SJ, Eckert S, Ning Z, Rice S, Cadiñanos J, Yusa K, Conte N, Bradley A Li MA, Pettitt SJ, Eckert S, Ning Z, Rice S, Cadiñanos J, Yusa K, Conte N, Bradley A Li MA, Pettitt SJ, Eckert S, Ning Z, Rice S, Cadiñanos J, Yusa K, Conte N, Bradley A The piggyBac transposon displays local and distant reintegration preferences and can cause mutations at noncanonical integration sites. The piggyBac transposon displays local and distant reintegration preferences and can cause mutations at noncanonical integration sites. The piggyBac transposon displays local and distant reintegration preferences and can cause mutations at noncanonical integration sites. Molecular and cellular biology, 33, 7, 1317-1330 Molecular and cellular biology, 33, 7, 1317-1330 Molecular and cellular biology, 33, 7, 1317-1330 2013/04 公開
Doherty JE, Huye LE, Yusa K, Zhou L, Craig NL, Wilson MH Doherty JE, Huye LE, Yusa K, Zhou L, Craig NL, Wilson MH Doherty JE, Huye LE, Yusa K, Zhou L, Craig NL, Wilson MH Hyperactive piggyBac gene transfer in human cells and in vivo. Hyperactive piggyBac gene transfer in human cells and in vivo. Hyperactive piggyBac gene transfer in human cells and in vivo. Human gene therapy, 23, 3, 311-320 Human gene therapy, 23, 3, 311-320 Human gene therapy, 23, 3, 311-320 2012/03 公開
Nijnik A, Clare S, Hale C, Raisen C, McIntyre RE, Yusa K, Everitt AR, Mottram L, Podrini C, Lucas M, Estabel J, Goulding D, Sanger Institute Microarray Facility., Sanger Mouse Genetics Project., Adams N, Ramirez-Solis R, White JK, Adams DJ, Hancock RE, Dougan G Nijnik A, Clare S, Hale C, Raisen C, McIntyre RE, Yusa K, Everitt AR, Mottram L, Podrini C, Lucas M, Estabel J, Goulding D, Sanger Institute Microarray Facility., Sanger Mouse Genetics Project., Adams N, Ramirez-Solis R, White JK, Adams DJ, Hancock RE, Dougan G Nijnik A, Clare S, Hale C, Raisen C, McIntyre RE, Yusa K, Everitt AR, Mottram L, Podrini C, Lucas M, Estabel J, Goulding D, Sanger Institute Microarray Facility., Sanger Mouse Genetics Project., Adams N, Ramirez-Solis R, White JK, Adams DJ, Hancock RE, Dougan G The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation. The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation. The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation. Blood, 119, 6, 1370-1379 Blood, 119, 6, 1370-1379 Blood, 119, 6, 1370-1379 2012/02 公開
Li MA, Turner DJ, Ning Z, Yusa K, Liang Q, Eckert S, Rad L, Fitzgerald TW, Craig NL, Bradley A Li MA, Turner DJ, Ning Z, Yusa K, Liang Q, Eckert S, Rad L, Fitzgerald TW, Craig NL, Bradley A Li MA, Turner DJ, Ning Z, Yusa K, Liang Q, Eckert S, Rad L, Fitzgerald TW, Craig NL, Bradley A Mobilization of giant piggyBac transposons in the mouse genome. Mobilization of giant piggyBac transposons in the mouse genome. Mobilization of giant piggyBac transposons in the mouse genome. Nucleic acids research, 39, 22, e148 Nucleic acids research, 39, 22, e148 Nucleic acids research, 39, 22, e148 2011/12 公開
Horie K, Kokubu C, Yoshida J, Akagi K, Isotani A, Oshitani A, Yusa K, Ikeda R, Huang Y, Bradley A, Takeda J Horie K, Kokubu C, Yoshida J, Akagi K, Isotani A, Oshitani A, Yusa K, Ikeda R, Huang Y, Bradley A, Takeda J Horie K, Kokubu C, Yoshida J, Akagi K, Isotani A, Oshitani A, Yusa K, Ikeda R, Huang Y, Bradley A, Takeda J A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening. A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening. A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening. Nature methods, 8, 12, 1071-1077 Nature methods, 8, 12, 1071-1077 Nature methods, 8, 12, 1071-1077 2011/10 公開
Yusa K, Rashid ST, Strick-Marchand H, Varela I, Liu PQ, Paschon DE, Miranda E, Ordóñez A, Hannan NR, Rouhani FJ, Darche S, Alexander G, Marciniak SJ, Fusaki N, Hasegawa M, Holmes MC, Di Santo JP, Lomas DA, Bradley A, Vallier L Yusa K, Rashid ST, Strick-Marchand H, Varela I, Liu PQ, Paschon DE, Miranda E, Ordóñez A, Hannan NR, Rouhani FJ, Darche S, Alexander G, Marciniak SJ, Fusaki N, Hasegawa M, Holmes MC, Di Santo JP, Lomas DA, Bradley A, Vallier L Yusa K, Rashid ST, Strick-Marchand H, Varela I, Liu PQ, Paschon DE, Miranda E, Ordóñez A, Hannan NR, Rouhani FJ, Darche S, Alexander G, Marciniak SJ, Fusaki N, Hasegawa M, Holmes MC, Di Santo JP, Lomas DA, Bradley A, Vallier L Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Nature, 478, 7369, 391-394 Nature, 478, 7369, 391-394 Nature, 478, 7369, 391-394 2011/10 公開
LaRocque JR, Stark JM, Oh J, Bojilova E, Yusa K, Horie K, Takeda J, Jasin M LaRocque JR, Stark JM, Oh J, Bojilova E, Yusa K, Horie K, Takeda J, Jasin M LaRocque JR, Stark JM, Oh J, Bojilova E, Yusa K, Horie K, Takeda J, Jasin M Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells. Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells. Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells. Proceedings of the National Academy of Sciences of the United States of America, 108, 29, 11971-11976 Proceedings of the National Academy of Sciences of the United States of America, 108, 29, 11971-11976 Proceedings of the National Academy of Sciences of the United States of America, 108, 29, 11971-11976 2011/07 公開
Yusa K, Zhou L, Li MA, Bradley A, Craig NL Yusa K, Zhou L, Li MA, Bradley A, Craig NL Yusa K, Zhou L, Li MA, Bradley A, Craig NL A hyperactive piggyBac transposase for mammalian applications. A hyperactive piggyBac transposase for mammalian applications. A hyperactive piggyBac transposase for mammalian applications. Proceedings of the National Academy of Sciences of the United States of America, 108, 4, 1531-1536 Proceedings of the National Academy of Sciences of the United States of America, 108, 4, 1531-1536 Proceedings of the National Academy of Sciences of the United States of America, 108, 4, 1531-1536 2011/01 公開
Rad R, Rad L, Wang W, Cadinanos J, Vassiliou G, Rice S, Campos LS, Yusa K, Banerjee R, Li MA, de la Rosa J, Strong A, Lu D, Ellis P, Conte N, Yang FT, Liu P, Bradley A Rad R, Rad L, Wang W, Cadinanos J, Vassiliou G, Rice S, Campos LS, Yusa K, Banerjee R, Li MA, de la Rosa J, Strong A, Lu D, Ellis P, Conte N, Yang FT, Liu P, Bradley A Rad R, Rad L, Wang W, Cadinanos J, Vassiliou G, Rice S, Campos LS, Yusa K, Banerjee R, Li MA, de la Rosa J, Strong A, Lu D, Ellis P, Conte N, Yang FT, Liu P, Bradley A PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice. PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice. PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice. Science (New York, N.Y.), 330, 6007, 1104-1107 Science (New York, N.Y.), 330, 6007, 1104-1107 Science (New York, N.Y.), 330, 6007, 1104-1107 2010/11 公開
Mali P, Chou BK, Yen J, Ye Z, Zou J, Dowey S, Brodsky RA, Ohm JE, Yu W, Baylin SB, Yusa K, Bradley A, Meyers DJ, Mukherjee C, Cole PA, Cheng L Mali P, Chou BK, Yen J, Ye Z, Zou J, Dowey S, Brodsky RA, Ohm JE, Yu W, Baylin SB, Yusa K, Bradley A, Meyers DJ, Mukherjee C, Cole PA, Cheng L Mali P, Chou BK, Yen J, Ye Z, Zou J, Dowey S, Brodsky RA, Ohm JE, Yu W, Baylin SB, Yusa K, Bradley A, Meyers DJ, Mukherjee C, Cole PA, Cheng L Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem cells (Dayton, Ohio), 28, 4, 713-720 Stem cells (Dayton, Ohio), 28, 4, 713-720 Stem cells (Dayton, Ohio), 28, 4, 713-720 2010/04 公開
Li MA, Pettitt SJ, Yusa K, Bradley A Li MA, Pettitt SJ, Yusa K, Bradley A Li MA, Pettitt SJ, Yusa K, Bradley A Genome-wide forward genetic screens in mouse ES cells. Genome-wide forward genetic screens in mouse ES cells. Genome-wide forward genetic screens in mouse ES cells. Methods in enzymology, 477, 217-242 Methods in enzymology, 477, 217-242 Methods in enzymology, 477, 217-242 2010 公開
Watanabe Y, Inoue K, Okuyama-Yamamoto A, Nakai N, Nakatani J, Nibu K, Sato N, Iiboshi Y, Yusa K, Kondoh G, Takeda J, Terashima T, Takumi T Watanabe Y, Inoue K, Okuyama-Yamamoto A, Nakai N, Nakatani J, Nibu K, Sato N, Iiboshi Y, Yusa K, Kondoh G, Takeda J, Terashima T, Takumi T Watanabe Y, Inoue K, Okuyama-Yamamoto A, Nakai N, Nakatani J, Nibu K, Sato N, Iiboshi Y, Yusa K, Kondoh G, Takeda J, Terashima T, Takumi T Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development. Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development. Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development. The Journal of comparative neurology, 515, 5, 565-584 The Journal of comparative neurology, 515, 5, 565-584 The Journal of comparative neurology, 515, 5, 565-584 2009/08 公開
Yusa K, Rad R, Takeda J, Bradley A Yusa K, Rad R, Takeda J, Bradley A Yusa K, Rad R, Takeda J, Bradley A Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nature methods, 6, 5, 363-369 Nature methods, 6, 5, 363-369 Nature methods, 6, 5, 363-369 2009/05 公開
Ikeda R, Kokubu C, Yusa K, Keng VW, Horie K, Takeda J Ikeda R, Kokubu C, Yusa K, Keng VW, Horie K, Takeda J Ikeda R, Kokubu C, Yusa K, Keng VW, Horie K, Takeda J Sleeping beauty transposase has an affinity for heterochromatin conformation. Sleeping beauty transposase has an affinity for heterochromatin conformation. Sleeping beauty transposase has an affinity for heterochromatin conformation. Molecular and cellular biology, 27, 5, 1665-1676 Molecular and cellular biology, 27, 5, 1665-1676 Molecular and cellular biology, 27, 5, 1665-1676 2007/03 公開
Akiyama K, Yusa K, Hashimoto H, Poonepalli A, Hande MP, Kakazu N, Takeda J, Tachibana M, Shinkai Y Akiyama K, Yusa K, Hashimoto H, Poonepalli A, Hande MP, Kakazu N, Takeda J, Tachibana M, Shinkai Y Akiyama K, Yusa K, Hashimoto H, Poonepalli A, Hande MP, Kakazu N, Takeda J, Tachibana M, Shinkai Y Rad54 is dispensable for the ALT pathway. Rad54 is dispensable for the ALT pathway. Rad54 is dispensable for the ALT pathway. Genes to cells : devoted to molecular & cellular mechanisms, 11, 11, 1305-1315 Genes to cells : devoted to molecular & cellular mechanisms, 11, 11, 1305-1315 Genes to cells : devoted to molecular & cellular mechanisms, 11, 11, 1305-1315 2006/11 公開
Yae K, Keng VW, Koike M, Yusa K, Kouno M, Uno Y, Kondoh G, Gotow T, Uchiyama Y, Horie K, Takeda J Yae K, Keng VW, Koike M, Yusa K, Kouno M, Uno Y, Kondoh G, Gotow T, Uchiyama Y, Horie K, Takeda J Yae K, Keng VW, Koike M, Yusa K, Kouno M, Uno Y, Kondoh G, Gotow T, Uchiyama Y, Horie K, Takeda J Sleeping beauty transposon-based phenotypic analysis of mice: lack of Arpc3 results in defective trophoblast outgrowth. Sleeping beauty transposon-based phenotypic analysis of mice: lack of Arpc3 results in defective trophoblast outgrowth. Sleeping beauty transposon-based phenotypic analysis of mice: lack of Arpc3 results in defective trophoblast outgrowth. Molecular and cellular biology, 26, 16, 6185-6196 Molecular and cellular biology, 26, 16, 6185-6196 Molecular and cellular biology, 26, 16, 6185-6196 2006/08 公開
Hayakawa T, Yusa K, Kouno M, Takeda J, Horie K Hayakawa T, Yusa K, Kouno M, Takeda J, Horie K Hayakawa T, Yusa K, Kouno M, Takeda J, Horie K Bloom's syndrome gene-deficient phenotype in mouse primary cells induced by a modified tetracycline-controlled trans-silencer. Bloom's syndrome gene-deficient phenotype in mouse primary cells induced by a modified tetracycline-controlled trans-silencer. Bloom's syndrome gene-deficient phenotype in mouse primary cells induced by a modified tetracycline-controlled trans-silencer. Gene, 369, 80-89 Gene, 369, 80-89 Gene, 369, 80-89 2006/03 公開
Keng VW, Yae K, Hayakawa T, Mizuno S, Uno Y, Yusa K, Kokubu C, Kinoshita T, Akagi K, Jenkins NA, Copeland NG, Horie K, Takeda J Keng VW, Yae K, Hayakawa T, Mizuno S, Uno Y, Yusa K, Kokubu C, Kinoshita T, Akagi K, Jenkins NA, Copeland NG, Horie K, Takeda J Keng VW, Yae K, Hayakawa T, Mizuno S, Uno Y, Yusa K, Kokubu C, Kinoshita T, Akagi K, Jenkins NA, Copeland NG, Horie K, Takeda J Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system. Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system. Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system. Nature methods, 2, 10, 763-769 Nature methods, 2, 10, 763-769 Nature methods, 2, 10, 763-769 2005/10 公開
Horie K, Yusa K, Takeda J Horie K, Yusa K, Takeda J Horie K, Yusa K, Takeda J [Recent progress in mouse transposon research]. [Recent progress in mouse transposon research]. [Recent progress in mouse transposon research]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 49, 13, 2117-2122 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 49, 13, 2117-2122 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 49, 13, 2117-2122 2004/10 公開
Yusa K, Horie K, Kondoh G, Kouno M, Maeda Y, Kinoshita T, Takeda J Yusa K, Horie K, Kondoh G, Kouno M, Maeda Y, Kinoshita T, Takeda J Yusa K, Horie K, Kondoh G, Kouno M, Maeda Y, Kinoshita T, Takeda J Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene. Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene. Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene. Nature, 429, 6994, 896-899 Nature, 429, 6994, 896-899 Nature, 429, 6994, 896-899 2004/06 公開
Yusa K, Takeda J, Horie K Yusa K, Takeda J, Horie K Yusa K, Takeda J, Horie K Enhancement of Sleeping Beauty transposition by CpG methylation: possible role of heterochromatin formation. Enhancement of Sleeping Beauty transposition by CpG methylation: possible role of heterochromatin formation. Enhancement of Sleeping Beauty transposition by CpG methylation: possible role of heterochromatin formation. Molecular and cellular biology, 24, 9, 4004-4018 Molecular and cellular biology, 24, 9, 4004-4018 Molecular and cellular biology, 24, 9, 4004-4018 2004/05 公開
Horie K, Yusa K, Yae K, Odajima J, Fischer SE, Keng VW, Hayakawa T, Mizuno S, Kondoh G, Ijiri T, Matsuda Y, Plasterk RH, Takeda J Horie K, Yusa K, Yae K, Odajima J, Fischer SE, Keng VW, Hayakawa T, Mizuno S, Kondoh G, Ijiri T, Matsuda Y, Plasterk RH, Takeda J Horie K, Yusa K, Yae K, Odajima J, Fischer SE, Keng VW, Hayakawa T, Mizuno S, Kondoh G, Ijiri T, Matsuda Y, Plasterk RH, Takeda J Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Molecular and cellular biology, 23, 24, 9189-9207 Molecular and cellular biology, 23, 24, 9189-9207 Molecular and cellular biology, 23, 24, 9189-9207 2003/12 公開
Yusa K, Horie K, Takeda J Yusa K, Horie K, Takeda J Yusa K, Horie K, Takeda J [New perspectives on genetically engineered mice in post-genomic era]. [New perspectives on genetically engineered mice in post-genomic era]. [New perspectives on genetically engineered mice in post-genomic era]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 48, 3, 232-239 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 48, 3, 232-239 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 48, 3, 232-239 2003/03 公開

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タイトル言語:
講演・口頭発表等
タイトル タイトル(日本語) タイトル(英語) 会議名 会議名(日本語) 会議名(英語) 主催者 主催者(日本語) 主催者(英語) 開催年月日 記述言語 会議種別 公開
Development and application of genome-wide CRISPR-KO screening[招待あり] Development and application of genome-wide CRISPR-KO screening [招待あり] Development and application of genome-wide CRISPR-KO screening [招待あり] SULSA Disruptive technologies SULSA Disruptive technologies SULSA Disruptive technologies 2019/09/26 英語 口頭発表(基調) 公開
Development and application of genome-wide CRISPR-KO screening[招待あり] Development and application of genome-wide CRISPR-KO screening [招待あり] 日本遺伝学会第91回大会 日本遺伝学会第91回大会 2019/09/13 英語 口頭発表(招待・特別) 公開
Development and application of genome-wide CRISPR-KO screening[招待あり] Development and application of genome-wide CRISPR-KO screening [招待あり] Development and application of genome-wide CRISPR-KO screening [招待あり] 東京大学先端科学技術研究センター 東京大学先端科学技術研究センター 2019/09/10 英語 公開講演、セミナー、チュートリアル、講習、講義 公開
Development and application of genome-wide CRISPR-KO screening Development and application of genome-wide CRISPR-KO screening Development and application of genome-wide CRISPR-KO screening 高遠 分子細胞生物学シンポジウム 高遠 分子細胞生物学シンポジウム 2019/08/23 英語 ポスター発表 公開
ゲノム編集技術を使ったがん研究[招待あり] ゲノム編集技術を使ったがん研究 [招待あり] ウイルス・再生医科学研究所公開講演会 ウイルス・再生医科学研究所公開講演会 2019/07/20 日本語 公開講演、セミナー、チュートリアル、講習、講義 公開
Oncology drug candidates identified from a large-scale genome-wide CRISPR screen Oncology drug candidates identified from a large-scale genome-wide CRISPR screen Oncology drug candidates identified from a large-scale genome-wide CRISPR screen 理化学研究所 和光 理化学研究所 和光 2019/01/21 英語 公開講演、セミナー、チュートリアル、講習、講義 公開
タイトル言語:
外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
国際共同研究加速基金(帰国発展研究) 代表 CRISPRスクリーニングを用いたヒトiPS細胞の内胚葉系分化機構の解明 (平成30年度分) 2018/04/01〜2019/03/31
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
分子遺伝学II Molecular Genetics II 前期 理学部 2019/04〜2020/03
部局運営(役職等)
役職名 期間
人権委員会 委員 2019/04/01〜
再生医科学動物実験専門委員会 委員 2018/10/01〜
化学物質管理委員会 2018/10/01〜