堀部 智久

最終更新日時: 2018/06/07 10:23:22

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氏名(漢字/フリガナ/アルファベット表記)
堀部 智久/ホリベ トモヒサ/Horibe, Tomohisa
所属部署・職名(部局/所属/講座等/職名)
医学研究科/社会健康医学系専攻健康解析学講座薬剤疫学/特定准教授
所属学会(国内)
学会名(日本語) 学会名(英語)
日本生化学会
日本分子生物学会
日本癌学会
日本がん分子標的治療学会
日本ペプチド学会
日本バイオイメージング学会
生物発光化学発光研究会
所属学会(海外)
学会名(英語) 国名
ASBMB
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
博士(理学) 立命館大学
出身大学院・研究科等
大学名(日本語) 大学名(英語) 研究科名(日本語) 研究科名(英語) 専攻名(日本語) 専攻名(英語) 修了区分
立命館大学 大学院理工学研究科総合理工学専攻博士後期課程 修了
立命館大学 大学院理工学研究科環境社会工学専攻博士前期課程 修了
出身学校・専攻等
大学名(日本語) 大学名(英語) 学部名(日本語) 学部名(英語) 学科名(日本語) 学科名(英語) 卒業区分
立命館大学 理工学部化学科 卒業
研究テーマ
(日本語)
新規抗癌分子標的ハイブリッドペプチドに関する研究、細胞内オルガネラ特異的ストレス応答に着目した分子標的抗癌剤の評価、神経変性疾患におけるシャペロンタンパク質の役割
(英語)
Studies on molecular trageted anti-cancer hybrid peptide, Functional roles of Protein disulfide isomerase family proteins in cancer cells, Simultaneous observation methods using bioluminescence and fluorescence at single cell level
研究概要
(日本語)
癌細胞表面に高発現する受容体および癌細胞内で重要な働きをするタンパク質を標的としたペプチドおよび癌細胞膜特異的に崩壊させるペプチドを組み合わせたハイブリッドペプチドの殺細胞効果ならびに、抗腫瘍効果を評価することで、新たな抗癌標的療法としての有用性を検討する。また、癌細胞内で特に重要な働きをする分子シャペロンの機能解析を一細胞レベル発光イメージング装置を用いて行い、発光イメージングの有用性を提示する。
(英語)
We focused on the targeting to several receptors, which over-express on the refractory cancer cells including pancreatic cancer and glioblastoma, and designed hybrid peptide in which targeting peptides to these receptors were conjugated with lytic type peptide that disintegrates selectively cancer cell membrane. We are currently confirming the potency of these hybrid peptides as novel molecular targeted anti-cancer agents. We are also focusing on molecular imaging using bioluminescence at single cell level for functional analysis of molecular chaperone in cancer cells.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
分子生物学
タンパク質工学
生化学
ペプチド
分子シャペロン
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Honjo Y, Ayaki T, Tomiyama T, Horibe T, Ito H, Mori H, Takahashi R, Kawakami K. Honjo Y, Ayaki T, Tomiyama T, Horibe T, Ito H, Mori H, Takahashi R, Kawakami K. Honjo Y, Ayaki T, Tomiyama T, Horibe T, Ito H, Mori H, Takahashi R, Kawakami K. Increased GADD34 in oligodendrocytes in Alzheimer’s disease. Increased GADD34 in oligodendrocytes in Alzheimer’s disease. Increased GADD34 in oligodendrocytes in Alzheimer’s disease. Neurosci Lett., 602, 50-55 Neurosci Lett., 602, 50-55 Neurosci Lett., 602, 50-55 2015 公開
Kohno M, Horibe T, Ohara K, Ito S, Kawakami K Kohno M, Horibe T, Ohara K, Ito S, Kawakami K Kohno M, Horibe T, Ohara K, Ito S, Kawakami K The membrane-lytic peptides K8L9 and melittin enter cancer cells via receptor endocytosis following subcytotoxic exposure. The membrane-lytic peptides K8L9 and melittin enter cancer cells via receptor endocytosis following subcytotoxic exposure. The membrane-lytic peptides K8L9 and melittin enter cancer cells via receptor endocytosis following subcytotoxic exposure. Chemistry & biology, 21, 11, 1522-1532 Chemistry & biology, 21, 11, 1522-1532 Chemistry & biology, 21, 11, 1522-1532 2014/11 公開
Horibe T, Torisawa A, Kohno M, Kawakami K Horibe T, Torisawa A, Kohno M, Kawakami K Horibe T, Torisawa A, Kohno M, Kawakami K Synergetic cytotoxic activity toward breast cancer cells enhanced by the combination of Antp-TPR hybrid peptide targeting Hsp90 and Hsp70-targeted peptide. Synergetic cytotoxic activity toward breast cancer cells enhanced by the combination of Antp-TPR hybrid peptide targeting Hsp90 and Hsp70-targeted peptide. Synergetic cytotoxic activity toward breast cancer cells enhanced by the combination of Antp-TPR hybrid peptide targeting Hsp90 and Hsp70-targeted peptide. BMC cancer, 14, 1 BMC cancer, 14, 1 BMC cancer, 14, 1 2014/08 公開
Gaowa A, Horibe T, Kohno M, Sato K, Harada H, Hiraoka M, Tabata Y, Kawakami K Gaowa A, Horibe T, Kohno M, Sato K, Harada H, Hiraoka M, Tabata Y, Kawakami K A. Gaowa; T. Horibe; M. Kohno; K. Sato; H. Harada; M. Hiraoka; Y. Tabata; K. Kawakami Combination of hybrid peptide with biodegradable gelatin hydrogel for controlled release and enhancement of anti-tumor activity in vivo. Combination of hybrid peptide with biodegradable gelatin hydrogel for controlled release and enhancement of anti-tumor activity in vivo. Combination of hybrid peptide with biodegradable gelatin hydrogel for controlled release and enhancement of anti-tumor activity in vivo Journal of controlled release : official journal of the Controlled Release Society, 176, 1-7 Journal of controlled release : official journal of the Controlled Release Society, 176, 1-7 Journal of Controlled Release, 176, 1-7 2014/02 英語 公開
Horibe T, Torisawa A, Akiyoshi R, Hatta-Ohashi Y, Suzuki H, Kawakami K Horibe T, Torisawa A, Akiyoshi R, Hatta-Ohashi Y, Suzuki H, Kawakami K T. Horibe; A. Torisawa; R. Akiyoshi; Y. Hatta-Ohashi; H. Suzuki; K. Kawakami Transfection efficiency of normal and cancer cell lines and monitoring of promoter activity by single-cell bioluminescence imaging. Transfection efficiency of normal and cancer cell lines and monitoring of promoter activity by single-cell bioluminescence imaging. Transfection efficiency of normal and cancer cell lines and monitoring of promoter activity by single-cell bioluminescence imaging Luminescence : the journal of biological and chemical luminescence, 29, 1, 96-100 Luminescence : the journal of biological and chemical luminescence, 29, 1, 96-100 Luminescence, 29, 1, 96-100 2014/02 英語 公開
Seto K, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami K Seto K, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami K Seto K, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami K Targeting interleukin-4 receptor alpha by hybrid Peptide for novel biliary tract cancer therapy. Targeting interleukin-4 receptor alpha by hybrid Peptide for novel biliary tract cancer therapy. Targeting interleukin-4 receptor alpha by hybrid Peptide for novel biliary tract cancer therapy. International journal of hepatology, 2014, 584650 International journal of hepatology, 2014, 584650 International journal of hepatology, 2014, 584650 2014 公開
Honjo Y, Horibe T, Torisawa A, Ito H, Nakanishi A, Mori H, Komiya T, Takahashi R, Kawakami K Honjo Y, Horibe T, Torisawa A, Ito H, Nakanishi A, Mori H, Komiya T, Takahashi R, Kawakami K Y. Honjo; T. Horibe; A. Torisawa; H. Ito; A. Nakanishi; H. Mori; T. Komiya; R. Takahashi; K. Kawakami Protein disulfide isomerase P5-immunopositive inclusions in patients with Alzheimer's disease. Protein disulfide isomerase P5-immunopositive inclusions in patients with Alzheimer's disease. Protein disulfide isomerase P5-immunopositive inclusions in patients with Alzheimer\\'s disease Journal of Alzheimer's disease : JAD, 38, 3, 601-609 Journal of Alzheimer's disease : JAD, 38, 3, 601-609 Journal of Alzheimer\\'s Disease, 38, 3, 601-609 2014 英語 公開
Seto K, Shoda J, Horibe T, Warabi E, Ishige K, Yamagata K, Kohno M, Yanagawa T, Bukawa H, Kawakami K Seto K, Shoda J, Horibe T, Warabi E, Ishige K, Yamagata K, Kohno M, Yanagawa T, Bukawa H, Kawakami K K. Seto; J. Shoda; T. Horibe; E. Warabi; K. Ishige; K. Yamagata; M. Kohno; T. Yanagawa; H. Bukawa; K. Kawakami Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma. Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma. Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma Oncology reports, 29, 6, 2147-2153 Oncology reports, 29, 6, 2147-2153 Oncology Reports, 29, 6, 2147-2153 2013/06 英語 公開
Kawamoto M, Horibe T, Kohno M, Kawakami K Kawamoto M, Horibe T, Kohno M, Kawakami K M. Kawamoto; T. Horibe; M. Kohno; K. Kawakami HER2-targeted hybrid peptide that blocks HER2 tyrosine kinase disintegrates cancer cell membrane and inhibits tumor growth in vivo. HER2-targeted hybrid peptide that blocks HER2 tyrosine kinase disintegrates cancer cell membrane and inhibits tumor growth in vivo. HER2-targeted hybrid peptide that blocks HER2 tyrosine kinase disintegrates cancer cell membrane and inhibits tumor growth in vivo Molecular cancer therapeutics, 12, 4, 384-393 Molecular cancer therapeutics, 12, 4, 384-393 Molecular Cancer Therapeutics, 12, 4, 384-393 2013/04 英語 公開
Ohara K, Kohno M, Horibe T, Kawakami K Ohara K, Kohno M, Horibe T, Kawakami K Ohara K, Kohno M, Horibe T, Kawakami K Local drug delivery to a human pancreatic tumor via a newly designed multiple injectable needle. Local drug delivery to a human pancreatic tumor via a newly designed multiple injectable needle. Local drug delivery to a human pancreatic tumor via a newly designed multiple injectable needle. Molecular and clinical oncology, 1, 2, 231-234 Molecular and clinical oncology, 1, 2, 231-234 Molecular and clinical oncology, 1, 2, 231-234 2013/03 公開
Kawamoto M, Kohno M, Horibe T, Kawakami K Kawamoto M, Kohno M, Horibe T, Kawakami K M. Kawamoto; M. Kohno; T. Horibe; K. Kawakami Immunogenicity and toxicity of transferrin receptor-targeted hybrid peptide as a potent anticancer agent. Immunogenicity and toxicity of transferrin receptor-targeted hybrid peptide as a potent anticancer agent. Immunogenicity and toxicity of transferrin receptor-targeted hybrid peptide as a potent anticancer agent Cancer chemotherapy and pharmacology, 71, 3, 799-807 Cancer chemotherapy and pharmacology, 71, 3, 799-807 Cancer Chemotherapy and Pharmacology, 71, 3, 799-807 2013/03 英語 公開
Sato Y, Kojima R, Okumura M, Hagiwara M, Masui S, Maegawa K, Saiki M, Horibe T, Suzuki M, Inaba K Sato Y, Kojima R, Okumura M, Hagiwara M, Masui S, Maegawa K, Saiki M, Horibe T, Suzuki M, Inaba K Y. Sato; R. Kojima; M. Okumura; M. Hagiwara; S. Masui; K.-I. Maegawa; M. Saiki; T. Horibe; M. Suzuki; K. Inaba Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding. Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding. Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding Scientific reports, 3 Scientific reports, 3 Scientific Reports, 3 2013 英語 公開
M. Kohno; K. Ohara; T. Horibe; K. Kawakami M. Kohno; K. Ohara; T. Horibe; K. Kawakami Inhibition of Neurite Outgrowth by a Neuropilin-1 Binding Peptide Derived from Semaphorin 3A Inhibition of Neurite Outgrowth by a Neuropilin-1 Binding Peptide Derived from Semaphorin 3A International Journal of Peptide Research and Therapeutics, 1-8 , 1-8 International Journal of Peptide Research and Therapeutics, 1-8 2013 英語 公開
Hinotsu, S., Yoshikawa, J., Murata, K., Horibe, T., and Kawakami, K. Hinotsu, S., Yoshikawa, J., Murata, K., Horibe, T., and Kawakami, K. Effect of lectures by medical students on the awareness of lifestyle for elementary school students. Effect of lectures by medical students on the awareness of lifestyle for elementary school students. J Obesity & Weight loss Ther (in press). J Obesity & Weight loss Ther (in press). 2013 英語 公開
T. Horibe; A. Torisawa; M. Kohno; K. Kawakami T. Horibe; A. Torisawa; M. Kohno; K. Kawakami Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells Molecular Cancer, 11 , 11 Molecular Cancer, 11 2012/08/22 英語 公開
Y. Honjo; H. Ito; T. Horibe; H. Shimada; A. Nakanishi; H. Mori; R. Takahashi; K. Kawakami Y. Honjo; H. Ito; T. Horibe; H. Shimada; A. Nakanishi; H. Mori; R. Takahashi; K. Kawakami Derlin-1-immunopositive inclusions in patients with Alzheimer\\'s disease Derlin-1-immunopositive inclusions in patients with Alzheimer\\'s disease NeuroReport, 23, 10, 611-615 , 23, 10, 611-615 NeuroReport, 23, 10, 611-615 2012/07/11 英語 公開
T. Horibe; M. Kawamoto; M. Kohno; K. Kawakami T. Horibe; M. Kawamoto; M. Kohno; K. Kawakami Cytotoxic activity to acute myeloid leukemia cells by Antp-TPR hybrid peptide targeting Hsp90 Cytotoxic activity to acute myeloid leukemia cells by Antp-TPR hybrid peptide targeting Hsp90 Journal of Bioscience and Bioengineering, 114, 1, 96-103 , 114, 1, 96-103 Journal of Bioscience and Bioengineering, 114, 1, 96-103 2012/07 英語 公開
H. Ueyama; T. Horibe; S. Hinotsu; T. Tanaka; T. Inoue; H. Urushihara; A. Kitagawa; K. Kawakami H. Ueyama; T. Horibe; S. Hinotsu; T. Tanaka; T. Inoue; H. Urushihara; A. Kitagawa; K. Kawakami Chromosomal variability of human mesenchymal stem cells cultured under hypoxic conditions Chromosomal variability of human mesenchymal stem cells cultured under hypoxic conditions Journal of Cellular and Molecular Medicine, 16, 1, 72-82 , 16, 1, 72-82 Journal of Cellular and Molecular Medicine, 16, 1, 72-82 2012/01 英語 公開
L. Yang; T. Horibe; M. Kohno; M. Haramoto; K. Ohara; R.K. Puri; K. Kawakami L. Yang; T. Horibe; M. Kohno; M. Haramoto; K. Ohara; R.K. Puri; K. Kawakami Targeting interleukin-4 receptor α with hybrid peptide for effective cancer therapy Targeting interleukin-4 receptor α with hybrid peptide for effective cancer therapy Molecular Cancer Therapeutics, 11, 1, 235-243 , 11, 1, 235-243 Molecular Cancer Therapeutics, 11, 1, 235-243 2012/01 英語 公開
M. Kishida; K. Ishige; T. Horibe; N. Tada; N. Koibuchi; J. Shoda; K. Kita; K. Kawakami M. Kishida; K. Ishige; T. Horibe; N. Tada; N. Koibuchi; J. Shoda; K. Kita; K. Kawakami Orexin 2 receptor as a potential target for immunotoxin and antibody-drug conjugate cancer therapy Orexin 2 receptor as a potential target for immunotoxin and antibody-drug conjugate cancer therapy Oncology Letters, 3, 3, 525-529 , 3, 3, 525-529 Oncology Letters, 3, 3, 525-529 2012 英語 公開
Horibe, T., Torisawa, A., Kohno, M., and Kawakami, K. Horibe, T., Torisawa, A., Kohno, M., and Kawakami, K. Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells. Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells. Mol Cancer, 11 , 11 Mol Cancer, 11 2012 英語 公開
Y. Honjo; S. Kaneko; H. Ito; T. Horibe; M. Nagashima; M. Nakamura; K. Fujita; R. Takahashi; H. Kusaka; K. Kawakami Y. Honjo; S. Kaneko; H. Ito; T. Horibe; M. Nagashima; M. Nakamura; K. Fujita; R. Takahashi; H. Kusaka; K. Kawakami Protein disulfide isomerase-immunopositive inclusions in patients with amyotrophic lateral sclerosis Protein disulfide isomerase-immunopositive inclusions in patients with amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis, 12, 6, 444-450 , 12, 6, 444-450 Amyotrophic Lateral Sclerosis, 12, 6, 444-450 2011/11 英語 公開
H. Ueyama; T. Horibe; O. Nakajima; K. Ohara; M. Kohno; K. Kawakami H. Ueyama; T. Horibe; O. Nakajima; K. Ohara; M. Kohno; K. Kawakami Semaphorin 3A lytic hybrid peptide binding to neuropilin-1 as a novel anti-cancer agent in pancreatic cancer Semaphorin 3A lytic hybrid peptide binding to neuropilin-1 as a novel anti-cancer agent in pancreatic cancer Biochemical and Biophysical Research Communications, 414, 1, 60-66 , 414, 1, 60-66 Biochemical and Biophysical Research Communications, 414, 1, 60-66 2011/10/14 英語 公開
M. Kawamoto; T. Horibe; M. Kohno; K. Kawakami M. Kawamoto; T. Horibe; M. Kohno; K. Kawakami A novel transferrin receptor-targeted hybrid peptide disintegrates cancer cell membrane to induce rapid killing of cancer cells A novel transferrin receptor-targeted hybrid peptide disintegrates cancer cell membrane to induce rapid killing of cancer cells BMC Cancer, 11 , 11 BMC Cancer, 11 2011/08/18 英語 公開
K. Ohara; T. Horibe; M. Kohno; K. Kawakami K. Ohara; T. Horibe; M. Kohno; K. Kawakami Characterization of antilytic peptide antibody: Application for the detection of lytic-based hybrid peptide in serum samples Characterization of antilytic peptide antibody: Application for the detection of lytic-based hybrid peptide in serum samples Journal of Peptide Science, 17, 7, 493-498 , 17, 7, 493-498 Journal of Peptide Science, 17, 7, 493-498 2011/07 英語 公開
N. Tada; T. Horibe; M. Haramoto; K. Ohara; M. Kohno; K. Kawakami N. Tada; T. Horibe; M. Haramoto; K. Ohara; M. Kohno; K. Kawakami A single replacement of histidine to arginine in EGFR-lytic hybrid peptide demonstrates the improved anticancer activity A single replacement of histidine to arginine in EGFR-lytic hybrid peptide demonstrates the improved anticancer activity Biochemical and Biophysical Research Communications, 407, 2, 383-388 , 407, 2, 383-388 Biochemical and Biophysical Research Communications, 407, 2, 383-388 2011/04/08 英語 公開
M. Kohno; T. Horibe; M. Haramoto; Y. Yano; K. Ohara; O. Nakajima; K. Matsuzaki; K. Kawakami M. Kohno; T. Horibe; M. Haramoto; Y. Yano; K. Ohara; O. Nakajima; K. Matsuzaki; K. Kawakami A novel hybrid peptide targeting EGFR-expressing cancers A novel hybrid peptide targeting EGFR-expressing cancers European Journal of Cancer, 47, 5, 773-783 , 47, 5, 773-783 European Journal of Cancer, 47, 5, 773-783 2011/03 英語 公開
T. Horibe; M. Kohno; M. Haramoto; K. Ohara; K. Kawakami T. Horibe; M. Kohno; M. Haramoto; K. Ohara; K. Kawakami Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent Journal of Translational Medicine, 9 , 9 Journal of Translational Medicine, 9 2011/01/14 英語 公開
Y. Honjo; H. Ito; T. Horibe; R. Takahashi; K. Kawakami Y. Honjo; H. Ito; T. Horibe; R. Takahashi; K. Kawakami Protein disulfide isomerase immunopositive glial cytoplasmic inclusions in patients with multiple system atrophy Protein disulfide isomerase immunopositive glial cytoplasmic inclusions in patients with multiple system atrophy International Journal of Neuroscience, 121, 10, 543-550 , 121, 10, 543-550 International Journal of Neuroscience, 121, 10, 543-550 2011 英語 公開
Y. Honjo; H. Ito; T. Horibe; R. Takahashi; K. Kawakami Y. Honjo; H. Ito; T. Horibe; R. Takahashi; K. Kawakami Protein disulfide isomerase-immunopositive inclusions in patients with Alzheimer disease Protein disulfide isomerase-immunopositive inclusions in patients with Alzheimer disease Brain Research, 1349, 90-96 , 1349, 90-96 Brain Research, 1349, 90-96 2010/08/19 英語 公開
M. Haramoto; M. Kohno; O. Nakajima; T. Horibe; M. Kiyohara; H. Fukazawa; T. Togawa; K. Kawakami M. Haramoto; M. Kohno; O. Nakajima; T. Horibe; M. Kiyohara; H. Fukazawa; T. Togawa; K. Kawakami Pancreatic cancer therapy with a novel pump for controlled drug release Pancreatic cancer therapy with a novel pump for controlled drug release Oncology Reports, 23, 2, 365-370 , 23, 2, 365-370 Oncology Reports, 23, 2, 365-370 2010/02 英語 公開
A. Son; N. Kato; T. Horibe; Y. Matsuo; M. Mochizuki; A. Mitsui; K. Kawakami; H. Nakamura; J. Yodoi A. Son; N. Kato; T. Horibe; Y. Matsuo; M. Mochizuki; A. Mitsui; K. Kawakami; H. Nakamura; J. Yodoi Direct association of thioredoxin-1 (TRX) with macrophage migration inhibitory factor (MIF): regulatory role of TRX on MIF internalization and signaling. Direct association of thioredoxin-1 (TRX) with macrophage migration inhibitory factor (MIF): regulatory role of TRX on MIF internalization and signaling. Antioxidants & redox signaling, 11, 10, 2595-2605 , 11, 10, 2595-2605 Antioxidants & redox signaling, 11, 10, 2595-2605 2009/10 英語 公開
O. Nakajima; D. Ichimaru; Y. Urata; T. Fujiwara; T. Horibe; M. Kohno; K. Kawakami O. Nakajima; D. Ichimaru; Y. Urata; T. Fujiwara; T. Horibe; M. Kohno; K. Kawakami Use of telomelysin (OBP-301) in mouse xenografts of human head and neck cancer Use of telomelysin (OBP-301) in mouse xenografts of human head and neck cancer Oncology Reports, 22, 5, 1039-1043 , 22, 5, 1039-1043 Oncology Reports, 22, 5, 1039-1043 2009 英語 公開
T. Kimura; T. Horibe; C. Sakamoto; Y. Shitara; F. Fujiwara; T. Komiya; A. Yamamoto; T. Hayano; N. Takahashi; M. Kikuchi T. Kimura; T. Horibe; C. Sakamoto; Y. Shitara; F. Fujiwara; T. Komiya; A. Yamamoto; T. Hayano; N. Takahashi; M. Kikuchi Evidence for mitochondrial localization of P5, a member of the protein disulphide isomerase family Evidence for mitochondrial localization of P5, a member of the protein disulphide isomerase family Journal of Biochemistry, 144, 2, 187-196 , 144, 2, 187-196 Journal of Biochemistry, 144, 2, 187-196 2008 英語 公開
T. Horibe; M. Kikuchi; K. Kawakami T. Horibe; M. Kikuchi; K. Kawakami Interaction of human protein disulfide isomerase and human P5 with drug compounds: Analysis using biosensor technology Interaction of human protein disulfide isomerase and human P5 with drug compounds: Analysis using biosensor technology Process Biochemistry, 43, 12, 1330-1337 , 43, 12, 1330-1337 Process Biochemistry, 43, 12, 1330-1337 2008 英語 公開
C.W. Gruber; M. Čemažar; R.J. Clark; T. Horibe; R.F. Renda; M.A. Anderson; D.J. Craik C.W. Gruber; M. Čemažar; R.J. Clark; T. Horibe; R.F. Renda; M.A. Anderson; D.J. Craik A novel plant protein-disulfide isomerase involved in the oxidative folding of cystine knot defense proteins A novel plant protein-disulfide isomerase involved in the oxidative folding of cystine knot defense proteins Journal of Biological Chemistry, 282, 28, 20435-20446 , 282, 28, 20435-20446 Journal of Biological Chemistry, 282, 28, 20435-20446 2007 英語 公開
T. Horibe; N.J. Hoogenraad T. Horibe; N.J. Hoogenraad The Chop gene contains an element for the positive regulation of the mitochondrial unfolded protein response The Chop gene contains an element for the positive regulation of the mitochondrial unfolded protein response PLoS ONE, 2, 9 , 2, 9 PLoS ONE, 2, 9 2007 英語 公開
J.E. Aldridge; T. Horibe; N.J. Hoogenraad J.E. Aldridge; T. Horibe; N.J. Hoogenraad Discovery of genes activated by the mitochondrial Unfolded Protein Response (mtUPR) and cognate promoter elements Discovery of genes activated by the mitochondrial Unfolded Protein Response (mtUPR) and cognate promoter elements PLoS ONE, 2, 9 , 2, 9 PLoS ONE, 2, 9 2007 英語 公開
T. Kimura; K. Imaishi; Y. Hagiwara; T. Horibe; T. Hayano; N. Takahashi; R. Urade; K. Kato; M. Kikuchi T. Kimura; K. Imaishi; Y. Hagiwara; T. Horibe; T. Hayano; N. Takahashi; R. Urade; K. Kato; M. Kikuchi ERp57 binds competitively to protein disulfide isomerase and calreticulin ERp57 binds competitively to protein disulfide isomerase and calreticulin Biochemical and Biophysical Research Communications, 331, 1, 224-230 , 331, 1, 224-230 Biochemical and Biophysical Research Communications, 331, 1, 224-230 2005 英語 公開
T. Kimura; Y. Hosoda; Y. Sato; Y. Kitamura; T. Ikeda; T. Horibe; M. Kikuchi T. Kimura; Y. Hosoda; Y. Sato; Y. Kitamura; T. Ikeda; T. Horibe; M. Kikuchi Interactions among yeast protein-disulfide isomerase proteins and endoplasmic reticulum chaperone proteins influence their activities Interactions among yeast protein-disulfide isomerase proteins and endoplasmic reticulum chaperone proteins influence their activities Journal of Biological Chemistry, 280, 36, 31438-31441 , 280, 36, 31438-31441 Journal of Biological Chemistry, 280, 36, 31438-31441 2005 英語 公開
M. Kikuchi; M. Kataoka; T. Kojima; T. Horibe; K. Fujieda; T. Kimura; T. Tanaka M. Kikuchi; M. Kataoka; T. Kojima; T. Horibe; K. Fujieda; T. Kimura; T. Tanaka Single chain antibodies that recognize the N-glycosylation site Single chain antibodies that recognize the N-glycosylation site Archives of Biochemistry and Biophysics, 422, 2, 221-229 , 422, 2, 221-229 Archives of Biochemistry and Biophysics, 422, 2, 221-229 2004 英語 公開
T. Horibe; M. Gomi; D. Iguchi; H. Ito; Y. Kitamura; T. Masuoka; I. Tsujimoto; T. Kimura; M. Kikuchi T. Horibe; M. Gomi; D. Iguchi; H. Ito; Y. Kitamura; T. Masuoka; I. Tsujimoto; T. Kimura; M. Kikuchi Different Contributions of the Three CXXC Motifs of Human Protein-disulfide Isomerase-related Protein to Isomerase Activity and Oxidative Refolding Different Contributions of the Three CXXC Motifs of Human Protein-disulfide Isomerase-related Protein to Isomerase Activity and Oxidative Refolding Journal of Biological Chemistry, 279, 6, 4604-4611 , 279, 6, 4604-4611 Journal of Biological Chemistry, 279, 6, 4604-4611 2004 英語 公開
T. Horibe; D. Iguchi; T. Masuoka; M. Gomi; T. Kimura; M. Kikuchi T. Horibe; D. Iguchi; T. Masuoka; M. Gomi; T. Kimura; M. Kikuchi Replacement of domain b of human protein disulfide isomerase-related protein with domain b′ of human protein disulfide isomerase dramatically increases its chaperone activity Replacement of domain b of human protein disulfide isomerase-related protein with domain b′ of human protein disulfide isomerase dramatically increases its chaperone activity FEBS Letters, 566, 1/3, 311-315 , 566, 1/3, 311-315 FEBS Letters, 566, 1/3, 311-315 2004 英語 公開
T. Kimura; Y. Hosoda; Y. Kitamura; H. Nakamura; T. Horibe; M. Kikuchi T. Kimura; Y. Hosoda; Y. Kitamura; H. Nakamura; T. Horibe; M. Kikuchi Functional differences between human and yeast protein disulfide isomerase family proteins Functional differences between human and yeast protein disulfide isomerase family proteins Biochemical and Biophysical Research Communications, 320, 2, 359-365 , 320, 2, 359-365 Biochemical and Biophysical Research Communications, 320, 2, 359-365 2004 英語 公開
T. Kimura; A. Nishida; N. Ohara; D. Yamagishi; T. Horibe; M. Kikuchi T. Kimura; A. Nishida; N. Ohara; D. Yamagishi; T. Horibe; M. Kikuchi Functional analysis of the CXXC motif using phage antibodies that cross-react with protein disulphide-isomerase family proteins Functional analysis of the CXXC motif using phage antibodies that cross-react with protein disulphide-isomerase family proteins Biochemical Journal, 382, 1, 169-176 , 382, 1, 169-176 Biochemical Journal, 382, 1, 169-176 2004 英語 公開
T. Horibe; H. Matsui; M. Tanaka; H. Nagai; Y. Yamaguchi; K. Kato; M. Kikuchi T. Horibe; H. Matsui; M. Tanaka; H. Nagai; Y. Yamaguchi; K. Kato; M. Kikuchi Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity Biochemical and Biophysical Research Communications, 323, 1, 281-287 , 323, 1, 281-287 Biochemical and Biophysical Research Communications, 323, 1, 281-287 2004 英語 公開
T. Horibe; H. Nagai; H. Matsui; Y. Hagiwara; M. Kikuchi T. Horibe; H. Nagai; H. Matsui; Y. Hagiwara; M. Kikuchi Aminoglycoside antibiotics bind to protein disulfide isomerase and inhibit its chaperone activity Aminoglycoside antibiotics bind to protein disulfide isomerase and inhibit its chaperone activity Journal of Antibiotics, 55, 5, 528-530 , 55, 5, 528-530 Journal of Antibiotics, 55, 5, 528-530 2002 英語 公開
M. Kikuchi; E. Doi; I. Tsujimoto; T. Horibe; Y. Tsujimoto M. Kikuchi; E. Doi; I. Tsujimoto; T. Horibe; Y. Tsujimoto Functional analysis of human P5, a protein disulfide isomerase homologue Functional analysis of human P5, a protein disulfide isomerase homologue Journal of Biochemistry, 132, 3, 451-455 , 132, 3, 451-455 Journal of Biochemistry, 132, 3, 451-455 2002 英語 公開
T. Horibe; C. Yosho; S. Okada; M. Tsukamoto; H. Nagai; Y. Hagiwara; Y. Tujimoto; M. Kikuchi T. Horibe; C. Yosho; S. Okada; M. Tsukamoto; H. Nagai; Y. Hagiwara; Y. Tujimoto; M. Kikuchi The chaperone activity of protein disulfide isomerase is affected by cyclophilin B and cyclosporin A in vitro The chaperone activity of protein disulfide isomerase is affected by cyclophilin B and cyclosporin A in vitro Journal of Biochemistry, 132, 3, 401-407 , 132, 3, 401-407 Journal of Biochemistry, 132, 3, 401-407 2002 英語 公開
T. Horibe; R. Furuya; A. Iwai; C. Yosho; Y. Tujimoto; M. Kikuchi T. Horibe; R. Furuya; A. Iwai; C. Yosho; Y. Tujimoto; M. Kikuchi The dipeptide, γ-glutamylcysteine, is recognized by the anti-glutathione antibody single chain Fv fragment 20C9 The dipeptide, γ-glutamylcysteine, is recognized by the anti-glutathione antibody single chain Fv fragment 20C9 Biochemical and Biophysical Research Communications, 281, 5, 1321-1324 , 281, 5, 1321-1324 Biochemical and Biophysical Research Communications, 281, 5, 1321-1324 2001 英語 公開
T. Horibe; M. Kikuchi T. Horibe; M. Kikuchi Nucleotide sequence of the porcine 60S ribosomal protein L35 cDNA Nucleotide sequence of the porcine 60S ribosomal protein L35 cDNA Mitochondrial DNA, 12, 5-6, 443-445 , 12, 5-6, 443-445 Mitochondrial DNA, 12, 5-6, 443-445 2001 英語 公開
T. Horibe; H. Nagai; K. Sakakibara; Y. Hagiwara; M. Kikuchi T. Horibe; H. Nagai; K. Sakakibara; Y. Hagiwara; M. Kikuchi Ribostamycin inhibits the chaperone activity of protein disulfide isomerase Ribostamycin inhibits the chaperone activity of protein disulfide isomerase Biochemical and Biophysical Research Communications, 289, 5, 967-972 , 289, 5, 967-972 Biochemical and Biophysical Research Communications, 289, 5, 967-972 2001 英語 公開

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タイトル言語:
Misc
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
孫安生,松尾禎之,堀部智久,川上浩二,中村肇,淀井淳司 孫安生,松尾禎之,堀部智久,川上浩二,中村肇,淀井淳司 Direct association of thioredoxin- 1 (TRX) with macrophage migration inhibitory factor (MIF); Regulatory role TRX on MIF internalization and signaling. Direct association of thioredoxin- 1 (TRX) with macrophage migration inhibitory factor (MIF); Regulatory role TRX on MIF internalization and signaling. 第32 回分子生物学会、横浜、2 0 0 9 年12 月11 日 第32 回分子生物学会、横浜、2 0 0 9 年12 月11 日 2009 英語 公開
タイトル言語:
書籍等出版物
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 出版社 出版社(日本語) 出版社(英語) 出版年月 記述言語 担当区分 公開
和訳 堀部智久 監修 川上浩司 和訳 堀部智久 監修 川上浩司 薬剤の低溶解性の克服 薬剤の低溶解性の克服 Pharm Tech Japan vol 29 (No 4), 143-150 Pharm Tech Japan vol 29 (No 4), 143-150 2013 日本語 公開
翻訳 堀部 智久 監修 川上浩司 翻訳 堀部 智久 監修 川上浩司 バイオプロセスにおける純粋培養工程をさらに改良するためのシンプルな戦略 バイオプロセスにおける純粋培養工程をさらに改良するためのシンプルな戦略 Pharm Tech Japan vol28(No 7), 79-92 Pharm Tech Japan vol28(No 7), 79-92 2012 日本語 公開
堀部智久、河野雅之、一丸大樹、川上浩司 堀部智久、河野雅之、一丸大樹、川上浩司 抗癌分子標的ハイブリッドペプチド 抗癌分子標的ハイブリッドペプチド 遺伝子医学MOOK 17号, 103-108 遺伝子医学MOOK 17号, 103-108 2010 日本語 公開
川上浩司、堀部智久 川上浩司、堀部智久 再生医療材料の安全性と臨床研究への応用 再生医療材料の安全性と臨床研究への応用 実験医学 増刊号 28, 152-158 実験医学 増刊号 28, 152-158 2010 日本語 公開
タイトル言語:
特許
発明者 発明者(日本語) 発明者(英語) 発明の名称 発明の名称(日本語) 発明の名称(英語) 審査の段階 番号 年月 公開
川上浩司、河野雅之、堀部智久 川上浩司、河野雅之、堀部智久 Hsp90を標的にした新規抗癌キメラペプチド Hsp90を標的にした新規抗癌キメラペプチド 特許出願 特願2010-537823 2008 公開
川上浩司、河野雅之、堀部智久、中島央美、楊麗英、原本真里 川上浩司、河野雅之、堀部智久、中島央美、楊麗英、原本真里 選択性に優れた抗がんキメラペプチド 選択性に優れた抗がんキメラペプチド 特許出願 特願2011-539160 2008 公開
タイトル言語:
外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
科学研究費助成事業 若手研究(B) 代表 オルガネラ特異的ストレス応答を標的とした新規抗癌分子標的薬の評価法の構築 2012/04/01〜2014/03/31
科学研究費助成事業 若手研究(B) 代表 プロテインジスルフィドイソメラーゼP5の人為的制御による新たな分子標的療法の開発 2014/04/01〜2016/03/31
基盤研究(C) 代表 悪性脳腫瘍におけるP5の機能的役割および新規分子標的としての有用性に関する研究 (平成28年度分) 2016/04/01〜2017/03/31
基盤研究(C) 代表 悪性脳腫瘍におけるP5の機能的役割および新規分子標的としての有用性に関する研究 (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(C) 代表 悪性脳腫瘍におけるP5の機能的役割および新規分子標的としての有用性に関する研究 (平成30年度分) 2018/04/01〜2019/03/31
科学研究費補助金 基盤研究(B) 分担 顕微注入法を用いない全卵ゲノム編集方法の開発 (平成29年度分) 2017/04/01〜2018/03/31
科学研究費補助金 基盤研究(B) 分担 顕微注入法を用いない全卵ゲノム編集方法の開発 (平成30年度分) 2018/04/01〜2019/03/31
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
高度医療看護論 Transplantation and Regeneration Nursing 前期前半 医学部(人間健康科学科) 2018/04〜2019/03
部局運営(役職等)
役職名 期間
動物実験施設運営委員会 2013/04/01〜2019/03/31