竹内 理

最終更新日時: 2020/07/06 11:44:19

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氏名(漢字/フリガナ/アルファベット表記)
竹内 理/タケウチ オサム/Takeuchi, Osamu
所属部署・職名(部局/所属/講座等/職名)
医学研究科/医学専攻分子生体統御学講座医化学/教授
協力講座
部局 所属 講座等 職名
医学研究科 医学専攻 感染防御生物学 教授
医学研究科 医科学専攻 感染防御生物学 教授
学部兼担
部局 所属 講座等 職名
医学部
連絡先住所
種別 住所(日本語) 住所(英語)
職場 〒606-8501 京都市左京区吉田近衛町 Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501
電子メールアドレス
メールアドレス
otake @ mfour.med.kyoto-u.ac.jp
所属学会(国内)
学会名(日本語) 学会名(英語)
日本免疫学会 Japanese Society for Immunology
日本分子生物学会 The Molecular Biology Society of Japan
日本生化学会 The Japanese Biochemical Society
日本ウイルス学会 The Japanese Society for Virology
日本RNA学会 The RNA Society of Japan
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
博士(医学) 大阪大学 Osaka University
プロフィール
(日本語)
ウイルスなど感染に対する宿主の防御応答に関する研究を行っている。特に病原体の初期認識から炎症を引き起こすステップである自然免疫の分子メカニズムに関し興味をもち、その制御機構に関し特に転写後制御の観点から研究を進めている。
(英語)
I am studying host defense responses against microbial infection. Particularly, I am interested in the molecular mechanisms of innate immunity, a immune system responsible for the initial recgonition of pathogens and evoking inflammatory responses.
個人ホームページ
URL
https://mc.mfour.med.kyoto-u.ac.jp/
researchmap URL
https://researchmap.jp/otakeuti
研究テーマ
(日本語)
自然免疫による炎症性制御メカニズムの解明
(英語)
Identification of regulatory mechanisms of inflammation via innate immunity
研究概要
(日本語)
自然免疫は感染の初期認識の他、様々なストレスに対する炎症の惹起に重要である。この炎症応答を制御する分子メカニズムに関し、(1) mRNA安定性制御を介したサイトカイン産生制御機構、(2) Toll-like receptor (TLR)シグナル伝達制御メカニズム、(3) TLR刺激に対する転写調節機構をを中心に、遺伝子改変マウスを用いて解析している。
(英語)
Innate immunity is critical not only for early recognition of pathogens, but also for evoking inflammation in response to various stresses. I have been analyzing molecular mechanisms regulating inflammation by focusing on (1) cytokine regulation via mRNA stability, (2) Toll-like receptor (TLR) signal transduction mechanisms and (3) regulation of gene transcription downstream of TLR using mouse models.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
自然免疫 Innate Immunity
mRNA安定性制御 mRNA stability
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Jingchi Gao, Yuichiro Hori, Osamu Takeuchi, Kazuya Kikuchi Jingchi Gao, Yuichiro Hori, Osamu Takeuchi, Kazuya Kikuchi Jingchi Gao, Yuichiro Hori, Osamu Takeuchi, Kazuya Kikuchi Live-Cell Imaging of Protein Degradation Utilizing Designed Protein-Tag Mutant and Fluorescent Probe with Turn-Off Switch Live-Cell Imaging of Protein Degradation Utilizing Designed Protein-Tag Mutant and Fluorescent Probe with Turn-Off Switch Live-Cell Imaging of Protein Degradation Utilizing Designed Protein-Tag Mutant and Fluorescent Probe with Turn-Off Switch Bioconjugate Chemistry, 31, 3, 577-583 Bioconjugate Chemistry, 31, 3, 577-583 Bioconjugate Chemistry, 31, 3, 577-583 2020/03/18 研究論文(学術雑誌) 公開
Nobuyuki Kakiuchi, Kenichi Yoshida, Motoi Uchino, Takako Kihara, Kotaro Akaki, Yoshikage Inoue, Kenji Kawada, Satoshi Nagayama, Akira Yokoyama, Shuji Yamamoto, Minoru Matsuura, Takahiro Horimatsu, Tomonori Hirano, Norihiro Goto, Yasuhide Takeuchi, Yotaro Ochi, Yusuke Shiozawa, Yasunori Kogure, Yosaku Watatani, Yoichi Fujii, Soo Ki Kim, Ayana Kon, Keisuke Kataoka, Tetsuichi Yoshizato, Masahiro M. Nakagawa, Akinori Yoda, Yasuhito Nanya, Hideki Makishima, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Eiji Sugihara, Taka aki Sato, Takashi Maruyama, Hiroyuki Miyoshi, Makoto Mark Taketo, Jun Oishi, Ryosaku Inagaki, Yutaka Ueda, Shinya Okamoto, Hideaki Okajima, Yoshiharu Sakai, Takaki Sakurai, Hironori Haga, Seiichi Hirota, Hiroki Ikeuchi, Hiroshi Nakase, Hiroyuki Marusawa, Tsutomu Chiba, Osamu Takeuchi, Satoru Miyano, Hiroshi Seno, Seishi Ogawa Nobuyuki Kakiuchi, Kenichi Yoshida, Motoi Uchino, Takako Kihara, Kotaro Akaki, Yoshikage Inoue, Kenji Kawada, Satoshi Nagayama, Akira Yokoyama, Shuji Yamamoto, Minoru Matsuura, Takahiro Horimatsu, Tomonori Hirano, Norihiro Goto, Yasuhide Takeuchi, Yotaro Ochi, Yusuke Shiozawa, Yasunori Kogure, Yosaku Watatani, Yoichi Fujii, Soo Ki Kim, Ayana Kon, Keisuke Kataoka, Tetsuichi Yoshizato, Masahiro M. Nakagawa, Akinori Yoda, Yasuhito Nanya, Hideki Makishima, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Eiji Sugihara, Taka aki Sato, Takashi Maruyama, Hiroyuki Miyoshi, Makoto Mark Taketo, Jun Oishi, Ryosaku Inagaki, Yutaka Ueda, Shinya Okamoto, Hideaki Okajima, Yoshiharu Sakai, Takaki Sakurai, Hironori Haga, Seiichi Hirota, Hiroki Ikeuchi, Hiroshi Nakase, Hiroyuki Marusawa, Tsutomu Chiba, Osamu Takeuchi, Satoru Miyano, Hiroshi Seno, Seishi Ogawa Nobuyuki Kakiuchi, Kenichi Yoshida, Motoi Uchino, Takako Kihara, Kotaro Akaki, Yoshikage Inoue, Kenji Kawada, Satoshi Nagayama, Akira Yokoyama, Shuji Yamamoto, Minoru Matsuura, Takahiro Horimatsu, Tomonori Hirano, Norihiro Goto, Yasuhide Takeuchi, Yotaro Ochi, Yusuke Shiozawa, Yasunori Kogure, Yosaku Watatani, Yoichi Fujii, Soo Ki Kim, Ayana Kon, Keisuke Kataoka, Tetsuichi Yoshizato, Masahiro M. Nakagawa, Akinori Yoda, Yasuhito Nanya, Hideki Makishima, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Eiji Sugihara, Taka aki Sato, Takashi Maruyama, Hiroyuki Miyoshi, Makoto Mark Taketo, Jun Oishi, Ryosaku Inagaki, Yutaka Ueda, Shinya Okamoto, Hideaki Okajima, Yoshiharu Sakai, Takaki Sakurai, Hironori Haga, Seiichi Hirota, Hiroki Ikeuchi, Hiroshi Nakase, Hiroyuki Marusawa, Tsutomu Chiba, Osamu Takeuchi, Satoru Miyano, Hiroshi Seno, Seishi Ogawa Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis Nature, 577, 7789, 260-265 Nature, 577, 7789, 260-265 Nature, 577, 7789, 260-265 2020/01/09 英語 研究論文(学術雑誌) 公開
Fabian Hia, Sheng Fan Yang, Yuichi Shichino, Masanori Yoshinaga, Yasuhiro Murakawa, Alexis Vandenbon, Akira Fukao, Toshinobu Fujiwara, Markus Landthaler, Tohru Natsume, Shungo Adachi, Shintaro Iwasaki, Osamu Takeuchi Fabian Hia, Sheng Fan Yang, Yuichi Shichino, Masanori Yoshinaga, Yasuhiro Murakawa, Alexis Vandenbon, Akira Fukao, Toshinobu Fujiwara, Markus Landthaler, Tohru Natsume, Shungo Adachi, Shintaro Iwasaki, Osamu Takeuchi Fabian Hia, Sheng Fan Yang, Yuichi Shichino, Masanori Yoshinaga, Yasuhiro Murakawa, Alexis Vandenbon, Akira Fukao, Toshinobu Fujiwara, Markus Landthaler, Tohru Natsume, Shungo Adachi, Shintaro Iwasaki, Osamu Takeuchi Codon bias confers stability to human mRNAs Codon bias confers stability to human mRNAs Codon bias confers stability to human mRNAs EMBO Reports, 20, 11, e48220 EMBO Reports, 20, 11, e48220 EMBO Reports, 20, 11, e48220 2019/11/05 研究論文(学術雑誌) 公開
Takashi Mino, Noriki Iwai, Masayuki Endo, Kentaro Inoue, Kotaro Akaki, Fabian Hia, Takuya Uehata, Tomoko Emura, Kumi Hidaka, Yutaka Suzuki, Daron M. Standley, Mariko Okada-Hatakeyama, Shigeo Ohno, Hiroshi Sugiyama, Akio Yamashita, Osamu Takeuchi Takashi Mino, Noriki Iwai, Masayuki Endo, Kentaro Inoue, Kotaro Akaki, Fabian Hia, Takuya Uehata, Tomoko Emura, Kumi Hidaka, Yutaka Suzuki, Daron M. Standley, Mariko Okada-Hatakeyama, Shigeo Ohno, Hiroshi Sugiyama, Akio Yamashita, Osamu Takeuchi Takashi Mino, Noriki Iwai, Masayuki Endo, Kentaro Inoue, Kotaro Akaki, Fabian Hia, Takuya Uehata, Tomoko Emura, Kumi Hidaka, Yutaka Suzuki, Daron M. Standley, Mariko Okada-Hatakeyama, Shigeo Ohno, Hiroshi Sugiyama, Akio Yamashita, Osamu Takeuchi Translation-dependent unwinding of stem-loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs Translation-dependent unwinding of stem-loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs Translation-dependent unwinding of stem-loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs Nucleic acids research, 47, 16, 8838-8859 Nucleic acids research, 47, 16, 8838-8859 Nucleic acids research, 47, 16, 8838-8859 2019/09/19 研究論文(学術雑誌) 公開
Shigeki Hirabayashi, Shruti Bhagat, Yu Matsuki, Yujiro Takegami, Takuya Uehata, Ai Kanemaru, Masayoshi Itoh, Kotaro Shirakawa, Akifumi Takaori-Kondo, Osamu Takeuchi, Piero Carninci, Shintaro Katayama, Yoshihide Hayashizaki, Juha Kere, Hideya Kawaji, Yasuhiro Murakawa Shigeki Hirabayashi, Shruti Bhagat, Yu Matsuki, Yujiro Takegami, Takuya Uehata, Ai Kanemaru, Masayoshi Itoh, Kotaro Shirakawa, Akifumi Takaori-Kondo, Osamu Takeuchi, Piero Carninci, Shintaro Katayama, Yoshihide Hayashizaki, Juha Kere, Hideya Kawaji, Yasuhiro Murakawa Shigeki Hirabayashi, Shruti Bhagat, Yu Matsuki, Yujiro Takegami, Takuya Uehata, Ai Kanemaru, Masayoshi Itoh, Kotaro Shirakawa, Akifumi Takaori-Kondo, Osamu Takeuchi, Piero Carninci, Shintaro Katayama, Yoshihide Hayashizaki, Juha Kere, Hideya Kawaji, Yasuhiro Murakawa NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements Nature Genetics, 51, 9, 1369-1379 Nature Genetics, 51, 9, 1369-1379 Nature Genetics, 51, 9, 1369-1379 2019/09/01 研究論文(学術雑誌) 公開
Daichi Yamasoba, Kei Sato, Takuya Ichinose, Tomoko Imamura, Lennart Koepke, Simone Joas, Elisabeth Reith, Dominik Hotter, Naoko Misawa, Kotaro Akaki, Takuya Uehata, Takashi Mino, Sho Miyamoto, Takeshi Noda, Akio Yamashita, Daron M. Standley, Frank Kirchhoff, Daniel Sauter, Yoshio Koyanagi, Osamu Takeuchi Daichi Yamasoba, Kei Sato, Takuya Ichinose, Tomoko Imamura, Lennart Koepke, Simone Joas, Elisabeth Reith, Dominik Hotter, Naoko Misawa, Kotaro Akaki, Takuya Uehata, Takashi Mino, Sho Miyamoto, Takeshi Noda, Akio Yamashita, Daron M. Standley, Frank Kirchhoff, Daniel Sauter, Yoshio Koyanagi, Osamu Takeuchi Daichi Yamasoba, Kei Sato, Takuya Ichinose, Tomoko Imamura, Lennart Koepke, Simone Joas, Elisabeth Reith, Dominik Hotter, Naoko Misawa, Kotaro Akaki, Takuya Uehata, Takashi Mino, Sho Miyamoto, Takeshi Noda, Akio Yamashita, Daron M. Standley, Frank Kirchhoff, Daniel Sauter, Yoshio Koyanagi, Osamu Takeuchi N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation Nature Microbiology, 4, 9, 1532-1544 Nature Microbiology, 4, 9, 1532-1544 Nature Microbiology, 4, 9, 1532-1544 2019/09/01 英語 研究論文(学術雑誌) 公開
Wang J, Sekai M, Matsui T, Fujii Y, Matsumoto M, Takeuchi O, Minato N, Hamazaki Y Wang J, Sekai M, Matsui T, Fujii Y, Matsumoto M, Takeuchi O, Minato N, Hamazaki Y Jianwei Wang, Miho Sekai, Takeshi Matsui, Yosuke Fujii, Mitsuru Matsumoto, Osamu Takeuchi, Nagahiro Minato, Yoko Hamazaki Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus. Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus. Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus International immunology, 31, 3, 127-139 International immunology, 31, 3, 127-139 International Immunology, 31, 3, 127-139 2019/03/05 研究論文(学術雑誌) 公開
Akitoshi Sadahiro, Akira Fukao, Mio Kosaka, Yoshinori Funakami, Naoki Takizawa, Osamu Takeuchi, Kent E. Duncan, Toshinobu Fujiwara Akitoshi Sadahiro, Akira Fukao, Mio Kosaka, Yoshinori Funakami, Naoki Takizawa, Osamu Takeuchi, Kent E. Duncan, Toshinobu Fujiwara Akitoshi Sadahiro, Akira Fukao, Mio Kosaka, Yoshinori Funakami, Naoki Takizawa, Osamu Takeuchi, Kent E. Duncan, Toshinobu Fujiwara Translation of hepatitis A virus IRES is upregulated by a hepatic cell-specific factor Translation of hepatitis A virus IRES is upregulated by a hepatic cell-specific factor Translation of hepatitis A virus IRES is upregulated by a hepatic cell-specific factor Frontiers in Genetics, 9, AUG, 307 Frontiers in Genetics, 9, AUG, 307 Frontiers in Genetics, 9, AUG, 307 2018/08/10 研究論文(学術雑誌) 公開
Yoshinari Nakatsuka, Alexis Vandenbon, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Xiaotong Cui, Ayuko Sato, Tohru Tsujimura, Yutaka Suzuki, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Teiji Sawa, Toyohiro Hirai, Osamu Takeuchi Yoshinari Nakatsuka, Alexis Vandenbon, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Xiaotong Cui, Ayuko Sato, Tohru Tsujimura, Yutaka Suzuki, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Teiji Sawa, Toyohiro Hirai, Osamu Takeuchi Yoshinari Nakatsuka, Alexis Vandenbon, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Xiaotong Cui, Ayuko Sato, Tohru Tsujimura, Yutaka Suzuki, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Teiji Sawa, Toyohiro Hirai, Osamu Takeuchi Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia article Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia article Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia article Mucosal Immunology, 11, 4, 1203-1218 Mucosal Immunology, 11, 4, 1203-1218 Mucosal Immunology, 11, 4, 1203-1218 2018/07/01 英語 研究論文(学術雑誌) 公開
吉永 正憲, 竹内 理 吉永 正憲, 竹内 理 【がんは免疫系をいかに抑制するのか 免疫チェックポイント阻害剤の真の標的を求めて】TAM・MDSCによる免疫抑制機構 【がんは免疫系をいかに抑制するのか 免疫チェックポイント阻害剤の真の標的を求めて】TAM・MDSCによる免疫抑制機構 実験医学, 36, 9, 1463-1467 実験医学, 36, 9, 1463-1467 , 36, 9, 1463-1467 2018/06 日本語 公開
吉永 正憲, 竹内 理 吉永 正憲, 竹内 理 生化学・分子生物学 RNA分解酵素Regnase-1による鉄代謝制御 生化学・分子生物学 RNA分解酵素Regnase-1による鉄代謝制御 医学のあゆみ, 265, 2, 157-158 医学のあゆみ, 265, 2, 157-158 , 265, 2, 157-158 2018/04 日本語 公開
Takuya Uehata, Osamu Takeuchi Takuya Uehata, Osamu Takeuchi Takuya Uehata, Osamu Takeuchi RNA-mediated mechanisms to regulate viral infection and gene expression in the innate immune system RNA-mediated mechanisms to regulate viral infection and gene expression in the innate immune system RNA-mediated mechanisms to regulate viral infection and gene expression in the innate immune system Seikagaku, 90, 3, 361-370 Seikagaku, 90, 3, 361-370 Seikagaku, 90, 3, 361-370 2018 研究論文(学術雑誌) 公開
Osamu Takeuchi Osamu Takeuchi Osamu Takeuchi Endonuclease Regnase-1/Monocyte chemotactic protein-1-induced protein-1 (MCPIP1) in controlling immune responses and beyond Endonuclease Regnase-1/Monocyte chemotactic protein-1-induced protein-1 (MCPIP1) in controlling immune responses and beyond Endonuclease Regnase-1/Monocyte chemotactic protein-1-induced protein-1 (MCPIP1) in controlling immune responses and beyond Wiley Interdisciplinary Reviews: RNA, 9, 1 Wiley Interdisciplinary Reviews: RNA, 9, 1 Wiley Interdisciplinary Reviews: RNA, 9, 1 2018 公開
Takashi Mino, Osamu Takeuchi Takashi Mino, Osamu Takeuchi Takashi Mino, Osamu Takeuchi Post-transcriptional regulation of immune responses by RNA binding proteins Post-transcriptional regulation of immune responses by RNA binding proteins Post-transcriptional regulation of immune responses by RNA binding proteins Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 94, 6, 248-258 Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 94, 6, 248-258 Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 94, 6, 248-258 2018 公開
Xiaotong Cui, Takashi Mino, Masanori Yoshinaga, Yoshinari Nakatsuka, Fabian Hia, Daichi Yamasoba, Tohru Tsujimura, Keizo Tomonaga, Yutaka Suzuki, Takuya Uehata, Osamu Takeuchi Xiaotong Cui, Takashi Mino, Masanori Yoshinaga, Yoshinari Nakatsuka, Fabian Hia, Daichi Yamasoba, Tohru Tsujimura, Keizo Tomonaga, Yutaka Suzuki, Takuya Uehata, Osamu Takeuchi Xiaotong Cui, Takashi Mino, Masanori Yoshinaga, Yoshinari Nakatsuka, Fabian Hia, Daichi Yamasoba, Tohru Tsujimura, Keizo Tomonaga, Yutaka Suzuki, Takuya Uehata, Osamu Takeuchi Regnase-1 and roquin nonredundantly regulate Th1 differentiation causing cardiac inflammation and fibrosis Regnase-1 and roquin nonredundantly regulate Th1 differentiation causing cardiac inflammation and fibrosis Regnase-1 and roquin nonredundantly regulate Th1 differentiation causing cardiac inflammation and fibrosis Journal of Immunology, 199, 12, 4066-4077 Journal of Immunology, 199, 12, 4066-4077 Journal of Immunology, 199, 12, 4066-4077 2017/12/15 英語 研究論文(学術雑誌) 公開
Takashi Mino, Osamu Takeuchi Takashi Mino, Osamu Takeuchi Takashi Mino, Osamu Takeuchi NSD3 keeps IRF3 active NSD3 keeps IRF3 active NSD3 keeps IRF3 active Journal of Experimental Medicine, 214, 12, 3475-3476 Journal of Experimental Medicine, 214, 12, 3475-3476 Journal of Experimental Medicine, 214, 12, 3475-3476 2017/12/01 英語 公開
Masanori Yoshinaga, Yoshinari Nakatsuka, Alexis Vandenbon, Daisuke Ori, Takuya Uehata, Tohru Tsujimura, Yutaka Suzuki, Takashi Mino, Osamu Takeuchi Masanori Yoshinaga, Yoshinari Nakatsuka, Alexis Vandenbon, Daisuke Ori, Takuya Uehata, Tohru Tsujimura, Yutaka Suzuki, Takashi Mino, Osamu Takeuchi Masanori Yoshinaga, Yoshinari Nakatsuka, Alexis Vandenbon, Daisuke Ori, Takuya Uehata, Tohru Tsujimura, Yutaka Suzuki, Takashi Mino, Osamu Takeuchi Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs Cell Reports, 19, 8, 1614-1630 Cell Reports, 19, 8, 1614-1630 Cell Reports, 19, 8, 1614-1630 2017/05/23 英語 研究論文(学術雑誌) 公開
Takuya Uehata, Osamu Takeuchi Takuya Uehata, Osamu Takeuchi Takuya Uehata, Osamu Takeuchi Regnase-1 is an endoribonuclease essential for the maintenance of immune homeostasis Regnase-1 is an endoribonuclease essential for the maintenance of immune homeostasis Regnase-1 is an endoribonuclease essential for the maintenance of immune homeostasis Journal of Interferon and Cytokine Research, 37, 5, 220-229 Journal of Interferon and Cytokine Research, 37, 5, 220-229 Journal of Interferon and Cytokine Research, 37, 5, 220-229 2017/05 英語 研究論文(学術雑誌) 公開
Tatsuya Kozaki, Jun Komano, Daiki Kanbayashi, Michihiro Takahama, Takuma Misawa, Takashi Satoh, Osamu Takeuchi, Taro Kawai, Shigeomi Shimizu, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh Tatsuya Kozaki, Jun Komano, Daiki Kanbayashi, Michihiro Takahama, Takuma Misawa, Takashi Satoh, Osamu Takeuchi, Taro Kawai, Shigeomi Shimizu, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh Tatsuya Kozaki, Jun Komano, Daiki Kanbayashi, Michihiro Takahama, Takuma Misawa, Takashi Satoh, Osamu Takeuchi, Taro Kawai, Shigeomi Shimizu, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response Proceedings of the National Academy of Sciences of the United States of America, 114, 10, 2681-2686 Proceedings of the National Academy of Sciences of the United States of America, 114, 10, 2681-2686 Proceedings of the National Academy of Sciences of the United States of America, 114, 10, 2681-2686 2017/03/07 英語 研究論文(学術雑誌) 公開
Sarang Tartey, Osamu Takeuchi Sarang Tartey, Osamu Takeuchi Sarang Tartey, Osamu Takeuchi Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells International Reviews of Immunology, 36, 2, 57-73 International Reviews of Immunology, 36, 2, 57-73 International Reviews of Immunology, 36, 2, 57-73 2017/03/04 英語 公開
Akio Yamashita, Osamu Takeuchi Akio Yamashita, Osamu Takeuchi Akio Yamashita, Osamu Takeuchi Translational control of mRNAs by 3'-Untranslated region binding proteins Translational control of mRNAs by 3'-Untranslated region binding proteins Translational control of mRNAs by 3'-Untranslated region binding proteins BMB Reports, 50, 4, 194-200 BMB Reports, 50, 4, 194-200 BMB Reports, 50, 4, 194-200 2017 英語 公開
吉永 正憲, 竹内 理 吉永 正憲, 竹内 理 【慢性炎症性疾患の新たな展開】慢性炎症のメカニズム 慢性炎症における炎症性サイトカインの新たな制御機構 【慢性炎症性疾患の新たな展開】慢性炎症のメカニズム 慢性炎症における炎症性サイトカインの新たな制御機構 最新医学, 71, 11月増刊, 2197-2201 最新医学, 71, 11月増刊, 2197-2201 , 71, 11月増刊, 2197-2201 2016/11 日本語 公開
吉永 正憲, 竹内 理 吉永 正憲, 竹内 理 【マクロファージのすべて】基礎 炎症性サイトカインIL-6とその転写後調節 【マクロファージのすべて】基礎 炎症性サイトカインIL-6とその転写後調節 医学のあゆみ, 259, 5, 371-376 医学のあゆみ, 259, 5, 371-376 , 259, 5, 371-376 2016/10 日本語 公開
Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda, Shizuo Akira Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda, Shizuo Akira Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda, Shizuo Akira Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product JOURNAL OF IMMUNOLOGY, 197, 7, 3749-3752 JOURNAL OF IMMUNOLOGY, 197, 7, 3749-3752 JOURNAL OF IMMUNOLOGY, 197, 7, 3749-3752 2016/10 英語 研究論文(学術雑誌) 公開
Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda, Shizuo Akira Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda, Shizuo Akira Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda, Shizuo Akira Cutting Edge: Toll-like receptor 4 (TLR4)-Deficient Mice Are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product Cutting Edge: Toll-like receptor 4 (TLR4)-Deficient Mice Are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product Cutting Edge: Toll-like receptor 4 (TLR4)-Deficient Mice Are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product Journal of Immunology, 197, 7, 2563-2566 Journal of Immunology, 197, 7, 2563-2566 Journal of Immunology, 197, 7, 2563-2566 2016/10/01 研究論文(学術雑誌) 公開
Ayako Ishikita, Tetsuya Matoba, Gentaro Ikeda, Jun Ichiro Koga, Yajing Mao, Kaku Nakano, Osamu Takeuchi, Junichi Sadoshima, Kensuke Egashira Ayako Ishikita, Tetsuya Matoba, Gentaro Ikeda, Jun Ichiro Koga, Yajing Mao, Kaku Nakano, Osamu Takeuchi, Junichi Sadoshima, Kensuke Egashira Ayako Ishikita, Tetsuya Matoba, Gentaro Ikeda, Jun Ichiro Koga, Yajing Mao, Kaku Nakano, Osamu Takeuchi, Junichi Sadoshima, Kensuke Egashira Nanoparticle-Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia-Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction Nanoparticle-Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia-Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction Nanoparticle-Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia-Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction Journal of the American Heart Association, 5, 7 Journal of the American Heart Association, 5, 7 Journal of the American Heart Association, 5, 7 2016/07/22 英語 研究論文(学術雑誌) 公開
Masuda, K, Ripley, B, Nyati, K, Dubey, P, Zaman, M, Hanieh, H, Hoga, M, Yamashita, K, Standley, D, Mashima, T, Katahira, M, Okamoto, T, Matsuura, Y, Takeuchi, O, Kishimoto, T Masuda, K, Ripley, B, Nyati, K, Dubey, P, Zaman, M, Hanieh, H, Hoga, M, Yamashita, K, Standley, D, Mashima, T, Katahira, M, Okamoto, T, Matsuura, Y, Takeuchi, O, Kishimoto, T Masuda, K, Ripley, B, Nyati, K, Dubey, P, Zaman, M, Hanieh, H, Hoga, M, Yamashita, K, Standley, D, Mashima, T, Katahira, M, Okamoto, T, Matsuura, Y, Takeuchi, O, Kishimoto, T Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA The Journal of experimental medicine, 213, 4, 605-619 The Journal of experimental medicine, 213, 4, 605-619 The Journal of experimental medicine, 213, 4, 605-619 2016/04/04 公開
Kazuya Masuda, Barry Ripley, Kishan Kumar Nyati, Praveen Kumar Dubey, Mohammad Mahabub Uz Zaman, Hamza Hanieh, Mitsuru Higa, Kazuo Yamashita, Daron M. Standley, Tsukasa Mashima, Masato Katahira, Toru Okamoto, Yoshiharu Matsuura, Osamu Takeuchi, Tadamitsu Kishimoto Kazuya Masuda, Barry Ripley, Kishan Kumar Nyati, Praveen Kumar Dubey, Mohammad Mahabub Uz Zaman, Hamza Hanieh, Mitsuru Higa, Kazuo Yamashita, Daron M. Standley, Tsukasa Mashima, Masato Katahira, Toru Okamoto, Yoshiharu Matsuura, Osamu Takeuchi, Tadamitsu Kishimoto Kazuya Masuda, Barry Ripley, Kishan Kumar Nyati, Praveen Kumar Dubey, Mohammad Mahabub Uz Zaman, Hamza Hanieh, Mitsuru Higa, Kazuo Yamashita, Daron M. Standley, Tsukasa Mashima, Masato Katahira, Toru Okamoto, Yoshiharu Matsuura, Osamu Takeuchi, Tadamitsu Kishimoto Arid5a regulates naive CD4<sup>+</sup> T cell fate through selective stabilization of Stat3 mRNA Arid5a regulates naive CD4<sup>+</sup> T cell fate through selective stabilization of Stat3 mRNA Arid5a regulates naive CD4<sup>+</sup> T cell fate through selective stabilization of Stat3 mRNA Journal of Experimental Medicine, 213, 4, 605-619 Journal of Experimental Medicine, 213, 4, 605-619 Journal of Experimental Medicine, 213, 4, 605-619 2016/04 英語 研究論文(学術雑誌) 公開
Mikaël M. Martino, Kenta Maruyama, Gisela A. Kuhn, Takashi Satoh, Osamu Takeuchi, Ralph Müller, Shizuo Akira Mikaël M. Martino, Kenta Maruyama, Gisela A. Kuhn, Takashi Satoh, Osamu Takeuchi, Ralph Müller, Shizuo Akira Mikaël M. Martino, Kenta Maruyama, Gisela A. Kuhn, Takashi Satoh, Osamu Takeuchi, Ralph Müller, Shizuo Akira Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration Nature Communications, 7, 11051 Nature Communications, 7, 11051 Nature Communications, 7, 11051 2016/03/22 英語 研究論文(学術雑誌) 公開
Mariko Yokogawa, Takashi Tsushima, Nobuo N. Noda, Hiroyuki Kumeta, Yoshiaki Enokizono, Kazuo Yamashita, Daron M. Standley, Osamu Takeuchi, Shizuo Akira, Fuyuhiko Inagaki Mariko Yokogawa, Takashi Tsushima, Nobuo N. Noda, Hiroyuki Kumeta, Yoshiaki Enokizono, Kazuo Yamashita, Daron M. Standley, Osamu Takeuchi, Shizuo Akira, Fuyuhiko Inagaki Mariko Yokogawa, Takashi Tsushima, Nobuo N. Noda, Hiroyuki Kumeta, Yoshiaki Enokizono, Kazuo Yamashita, Daron M. Standley, Osamu Takeuchi, Shizuo Akira, Fuyuhiko Inagaki Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions Scientific Reports, 6, 22324 Scientific Reports, 6, 22324 Scientific Reports, 6, 22324 2016/03/01 英語 研究論文(学術雑誌) 公開
Sarang Tartey, Osamu Takeuchi Sarang Tartey, Osamu Takeuchi Sarang Tartey, Osamu Takeuchi Akirin2-mediated transcriptional control by recruiting SWI/SNF complex in B cells Akirin2-mediated transcriptional control by recruiting SWI/SNF complex in B cells Akirin2-mediated transcriptional control by recruiting SWI/SNF complex in B cells Critical Reviews in Immunology, 36, 5, 395-406 Critical Reviews in Immunology, 36, 5, 395-406 Critical Reviews in Immunology, 36, 5, 395-406 2016 英語 研究論文(学術雑誌) 公開
Takashi Mino, Osamu Takeuchi Takashi Mino, Osamu Takeuchi Takashi Mino, Osamu Takeuchi Post-transcriptional regulation of inflammatory mRNA by Regnase-1 and Roquin Post-transcriptional regulation of inflammatory mRNA by Regnase-1 and Roquin Post-transcriptional regulation of inflammatory mRNA by Regnase-1 and Roquin Folia Pharmacologica Japonica, 147, 6, 351-356 Folia Pharmacologica Japonica, 147, 6, 351-356 Folia Pharmacologica Japonica, 147, 6, 351-356 2016 公開
吉永 正憲, 竹内 理 吉永 正憲, 竹内 理 炎症制御の分子機構 炎症制御の分子機構 臨床免疫・アレルギー科, 64, 4, 416-420 臨床免疫・アレルギー科, 64, 4, 416-420 , 64, 4, 416-420 2015/10 日本語 公開
Sarang Tartey, Osamu Takeuchi Sarang Tartey, Osamu Takeuchi Sarang Tartey, Osamu Takeuchi Chromatin remodeling and transcriptional control in innate immunity: Emergence of Akirin2 as a novel player Chromatin remodeling and transcriptional control in innate immunity: Emergence of Akirin2 as a novel player Chromatin remodeling and transcriptional control in innate immunity: Emergence of Akirin2 as a novel player Biomolecules, 5, 3, 1618-1633 Biomolecules, 5, 3, 1618-1633 Biomolecules, 5, 3, 1618-1633 2015/07/22 公開
Sarang Tartey, Kazufumi Matsushita, Tomoko Imamura, Atsuko Wakabayashi, Daisuke Ori, Takashi Mino, Osamu Takeuchi Sarang Tartey, Kazufumi Matsushita, Tomoko Imamura, Atsuko Wakabayashi, Daisuke Ori, Takashi Mino, Osamu Takeuchi Sarang Tartey, Kazufumi Matsushita, Tomoko Imamura, Atsuko Wakabayashi, Daisuke Ori, Takashi Mino, Osamu Takeuchi Essential function for the nuclear protein akirin2 in B cell activation and humoral immune responses Essential function for the nuclear protein akirin2 in B cell activation and humoral immune responses Essential function for the nuclear protein akirin2 in B cell activation and humoral immune responses Journal of Immunology, 195, 2, 519-527 Journal of Immunology, 195, 2, 519-527 Journal of Immunology, 195, 2, 519-527 2015/07/15 英語 研究論文(学術雑誌) 公開
Takashi Mino, Yasuhiro Murakawa, Akira Fukao, Alexis Vandenbon, Hans Hermann Wessels, Daisuke Ori, Takuya Uehata, Sarang Tartey, Shizuo Akira, Yutaka Suzuki, Carola G. Vinuesa, Uwe Ohler, Daron M. Standley, Markus Landthaler, Toshinobu Fujiwara, Osamu Takeuchi Takashi Mino, Yasuhiro Murakawa, Akira Fukao, Alexis Vandenbon, Hans Hermann Wessels, Daisuke Ori, Takuya Uehata, Sarang Tartey, Shizuo Akira, Yutaka Suzuki, Carola G. Vinuesa, Uwe Ohler, Daron M. Standley, Markus Landthaler, Toshinobu Fujiwara, Osamu Takeuchi Takashi Mino, Yasuhiro Murakawa, Akira Fukao, Alexis Vandenbon, Hans Hermann Wessels, Daisuke Ori, Takuya Uehata, Sarang Tartey, Shizuo Akira, Yutaka Suzuki, Carola G. Vinuesa, Uwe Ohler, Daron M. Standley, Markus Landthaler, Toshinobu Fujiwara, Osamu Takeuchi Regnase-1 and roquin regulate a common element in inflammatory mRNAs by spatiotemporally distinct mechanisms Regnase-1 and roquin regulate a common element in inflammatory mRNAs by spatiotemporally distinct mechanisms Regnase-1 and roquin regulate a common element in inflammatory mRNAs by spatiotemporally distinct mechanisms Cell, 161, 5, 1058-1073 Cell, 161, 5, 1058-1073 Cell, 161, 5, 1058-1073 2015/05/30 英語 研究論文(学術雑誌) 公開
Masahiro Fukasaka, Daisuke Asari, Eiji Kiyotoh, Arimichi Okazaki, Yasuyuki Gomi, Takeshi Tanimoto, Osamu Takeuchi, Shizuo Akira, Mitsuhiko Hori Masahiro Fukasaka, Daisuke Asari, Eiji Kiyotoh, Arimichi Okazaki, Yasuyuki Gomi, Takeshi Tanimoto, Osamu Takeuchi, Shizuo Akira, Mitsuhiko Hori Masahiro Fukasaka, Daisuke Asari, Eiji Kiyotoh, Arimichi Okazaki, Yasuyuki Gomi, Takeshi Tanimoto, Osamu Takeuchi, Shizuo Akira, Mitsuhiko Hori A lipopolysaccharide from pantoea agglomerans is a promising adjuvant for sublingual vaccines to induce systemic and mucosal immune responses in Mice via TLR4 pathway A lipopolysaccharide from pantoea agglomerans is a promising adjuvant for sublingual vaccines to induce systemic and mucosal immune responses in Mice via TLR4 pathway A lipopolysaccharide from pantoea agglomerans is a promising adjuvant for sublingual vaccines to induce systemic and mucosal immune responses in Mice via TLR4 pathway PLoS ONE, 10, 5, e0126849 PLoS ONE, 10, 5, e0126849 PLoS ONE, 10, 5, e0126849 2015/05/15 英語 研究論文(学術雑誌) 公開
Takeuchi O Takeuchi O Osamu Takeuchi HuR keeps interferon-β mRNA stable. HuR keeps interferon-β mRNA stable. HuR keeps interferon-β mRNA stable European journal of immunology, 45, 5, 1296-1299 European journal of immunology, 45, 5, 1296-1299 European Journal of Immunology, 45, 5, 1296-1299 2015/05/01 英語 研究論文(学術雑誌) 公開
Kenta Maruyama, Masahiro Fukasaka, Satoshi Uematsu, Osamu Takeuchi, Takeshi Kondo, Tatsuya Saitoh, Mikaël M. Martino, Shizuo Akira Kenta Maruyama, Masahiro Fukasaka, Satoshi Uematsu, Osamu Takeuchi, Takeshi Kondo, Tatsuya Saitoh, Mikaël M. Martino, Shizuo Akira Kenta Maruyama, Masahiro Fukasaka, Satoshi Uematsu, Osamu Takeuchi, Takeshi Kondo, Tatsuya Saitoh, Mikaël M. Martino, Shizuo Akira 5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival 5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival 5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival Journal of Biological Chemistry, 290, 15, 9377-9386 Journal of Biological Chemistry, 290, 15, 9377-9386 Journal of Biological Chemistry, 290, 15, 9377-9386 2015/04 英語 研究論文(学術雑誌) 公開
Sanki Asakawa, Yu Kishimoto, Takayuki Takano, Kiyuki Okita, Shiho Takakuwa, Taiki Sato, Masahiro Hiratsuka, Osamu Takeuchi, Noriyasu Hirasawa Sanki Asakawa, Yu Kishimoto, Takayuki Takano, Kiyuki Okita, Shiho Takakuwa, Taiki Sato, Masahiro Hiratsuka, Osamu Takeuchi, Noriyasu Hirasawa Sanki Asakawa, Yu Kishimoto, Takayuki Takano, Kiyuki Okita, Shiho Takakuwa, Taiki Sato, Masahiro Hiratsuka, Osamu Takeuchi, Noriyasu Hirasawa Nickel ions selectively inhibit lipopolysaccharide-inducedinterleukin-6 production by decreasing its mRNA stability Nickel ions selectively inhibit lipopolysaccharide-inducedinterleukin-6 production by decreasing its mRNA stability Nickel ions selectively inhibit lipopolysaccharide-inducedinterleukin-6 production by decreasing its mRNA stability PLoS ONE, 10, 3, e0119428 PLoS ONE, 10, 3, e0119428 PLoS ONE, 10, 3, e0119428 2015/03/05 英語 研究論文(学術雑誌) 公開
Meghana N. Patel, William G. Bernard, Nikolay B. Milev, William P. Cawthorn, Nichola Figg, Dan Hart, Xavier Prieur, Sam Virtue, Krisztina Hegyi, Stephanie Bonnafous, Beatrice Bailly-Maitre, Yajing Chuf, Julian L. Griffinf, Ziad Mallat, Robert V. Considineh, Albert Tranc, Philippe Gual, Osamu Takeuchi, Shizuo Akira, Antonio Vidal-Pui, Martin R. Bennett, Jaswinder K. Sethi Meghana N. Patel, William G. Bernard, Nikolay B. Milev, William P. Cawthorn, Nichola Figg, Dan Hart, Xavier Prieur, Sam Virtue, Krisztina Hegyi, Stephanie Bonnafous, Beatrice Bailly-Maitre, Yajing Chuf, Julian L. Griffinf, Ziad Mallat, Robert V. Considineh, Albert Tranc, Philippe Gual, Osamu Takeuchi, Shizuo Akira, Antonio Vidal-Pui, Martin R. Bennett, Jaswinder K. Sethi Meghana N. Patel, William G. Bernard, Nikolay B. Milev, William P. Cawthorn, Nichola Figg, Dan Hart, Xavier Prieur, Sam Virtue, Krisztina Hegyi, Stephanie Bonnafous, Beatrice Bailly-Maitre, Yajing Chuf, Julian L. Griffinf, Ziad Mallat, Robert V. Considineh, Albert Tranc, Philippe Gual, Osamu Takeuchi, Shizuo Akira, Antonio Vidal-Pui, Martin R. Bennett, Jaswinder K. Sethi Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation Proceedings of the National Academy of Sciences of the United States of America, 112, 2, 506-511 Proceedings of the National Academy of Sciences of the United States of America, 112, 2, 506-511 Proceedings of the National Academy of Sciences of the United States of America, 112, 2, 506-511 2015/01/13 英語 研究論文(学術雑誌) 公開
Takashi Mino, Osamu Takeuchi Takashi Mino, Osamu Takeuchi Takashi Mino, Osamu Takeuchi Regnase-1 and Roquin regulate inflammatory mRNAs Regnase-1 and Roquin regulate inflammatory mRNAs Regnase-1 and Roquin regulate inflammatory mRNAs Oncotarget, 6, 20, 17869-17870 Oncotarget, 6, 20, 17869-17870 Oncotarget, 6, 20, 17869-17870 2015 英語 研究論文(学術雑誌) 公開
Yuichi Kitai, Osamu Takeuchi, Takumi Kawasaki, Daisuke Ori, Takuya Sueyoshi, Motoya Murase, Shizuo Akira, Taro Kawai Yuichi Kitai, Osamu Takeuchi, Takumi Kawasaki, Daisuke Ori, Takuya Sueyoshi, Motoya Murase, Shizuo Akira, Taro Kawai Yuichi Kitai, Osamu Takeuchi, Takumi Kawasaki, Daisuke Ori, Takuya Sueyoshi, Motoya Murase, Shizuo Akira, Taro Kawai Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by arf-like protein 5B Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by arf-like protein 5B Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by arf-like protein 5B Journal of Biological Chemistry, 290, 2, 1269-1280 Journal of Biological Chemistry, 290, 2, 1269-1280 Journal of Biological Chemistry, 290, 2, 1269-1280 2015/01/01 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi Osamu Takeuchi Osamu Takeuchi Posttranscriptional control of inflammation by an RNase regnase-1 Posttranscriptional control of inflammation by an RNase regnase-1 Posttranscriptional control of inflammation by an RNase regnase-1 Folia Pharmacologica Japonica, 145, 3, 129-133 Folia Pharmacologica Japonica, 145, 3, 129-133 Folia Pharmacologica Japonica, 145, 3, 129-133 2015 公開
Tartey S, Matsushita K, Vandenbon A, Ori D, Imamura T, Mino T, Standley DM, Hoffmann JA, Reichhart JM, Akira S, Takeuchi O Tartey S, Matsushita K, Vandenbon A, Ori D, Imamura T, Mino T, Standley DM, Hoffmann JA, Reichhart JM, Akira S, Takeuchi O Sarang Tartey, Kazufumi Matsushita, Alexis Vandenbon, Daisuke Ori, Tomoko Imamura, Takashi Mino, Daron M. Standley, Jules A. Hoffmann, Jean Marc Reichhart, Shizuo Akira, Osamu Takeuchi Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex. Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex. Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex The EMBO journal, 33, 20, 2332-2348 The EMBO journal, 33, 20, 2332-2348 EMBO Journal, 33, 20, 2332-2348 2014/10/16 英語 研究論文(学術雑誌) 公開
Bonnay F, Nguyen XH, Cohen-Berros E, Troxler L, Batsche E, Camonis J, Takeuchi O, Reichhart JM, Matt N Bonnay F, Nguyen XH, Cohen-Berros E, Troxler L, Batsche E, Camonis J, Takeuchi O, Reichhart JM, Matt N François Bonnay, Xuan Hung Nguyen, Eva Cohen-Berros, Laurent Troxler, Eric Batsche, Jacques Camonis, Osamu Takeuchi, Jean Marc Reichhart, Nicolas Matt Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling. Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling. Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling The EMBO journal, 33, 20, 2349-2362 The EMBO journal, 33, 20, 2349-2362 EMBO Journal, 33, 20, 2349-2362 2014/10/16 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi Osamu Takeuchi Osamu Takeuchi [Innate immunity] [Innate immunity] [Innate immunity] [Rinshō ketsueki] The Japanese journal of clinical hematology, 55, 10, 2175-2182 [Rinshō ketsueki] The Japanese journal of clinical hematology, 55, 10, 2175-2182 [Rinshō ketsueki] The Japanese journal of clinical hematology, 55, 10, 2175-2182 2014/10/01 公開
Kanako Kuniyoshi, Osamu Takeuchi, Surya Pandey, Takashi Satoh, Hidenori Iwasaki, Shizuo Akira, Taro Kawai Kanako Kuniyoshi, Osamu Takeuchi, Surya Pandey, Takashi Satoh, Hidenori Iwasaki, Shizuo Akira, Taro Kawai Kanako Kuniyoshi, Osamu Takeuchi, Surya Pandey, Takashi Satoh, Hidenori Iwasaki, Shizuo Akira, Taro Kawai Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity Proceedings of the National Academy of Sciences of the United States of America, 111, 15, 5646-5651 Proceedings of the National Academy of Sciences of the United States of America, 111, 15, 5646-5651 Proceedings of the National Academy of Sciences of the United States of America, 111, 15, 5646-5651 2014/04 英語 研究論文(学術雑誌) 公開
Sarang Tartey, Osamu Takeuchi Sarang Tartey, Osamu Takeuchi Sarang Tartey, Osamu Takeuchi Toll-Like Receptors: Role in Inflammation and Cancer Toll-Like Receptors: Role in Inflammation and Cancer Toll-Like Receptors: Role in Inflammation and Cancer Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects, 83-102 Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects, 83-102 Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects, 83-102 2014/03/31 公開
Takayuki Imanishi, Chitose Ishihara, Mohamed E.l.Sherif G.adelhaq Badr, Akiko Hashimoto-Tane, Yayoi Kimura, Taro Kawai, Osamu Takeuchi, Ken J. Ishii, Shun'ichiro Taniguchi, Tetsuo Noda, Hisashi Hirano, Frank Brombacher, Glen N. Barber, Shizuo Akira, Takashi Saito Takayuki Imanishi, Chitose Ishihara, Mohamed E.l.Sherif G.adelhaq Badr, Akiko Hashimoto-Tane, Yayoi Kimura, Taro Kawai, Osamu Takeuchi, Ken J. Ishii, Shun'ichiro Taniguchi, Tetsuo Noda, Hisashi Hirano, Frank Brombacher, Glen N. Barber, Shizuo Akira, Takashi Saito Takayuki Imanishi, Chitose Ishihara, Mohamed E.l.Sherif G.adelhaq Badr, Akiko Hashimoto-Tane, Yayoi Kimura, Taro Kawai, Osamu Takeuchi, Ken J. Ishii, Shun'ichiro Taniguchi, Tetsuo Noda, Hisashi Hirano, Frank Brombacher, Glen N. Barber, Shizuo Akira, Takashi Saito Nucleic acid sensing by T cells initiates Th2 cell differentiation Nucleic acid sensing by T cells initiates Th2 cell differentiation Nucleic acid sensing by T cells initiates Th2 cell differentiation Nature communications, 5, 3566 Nature communications, 5, 3566 Nature communications, 5, 3566 2014 英語 研究論文(学術雑誌) 公開
Alexis Vandenbon, Shunsuke Teraguchi, Osamu Takeuchi, Yutaka Suzuki, Daron M. Standley Alexis Vandenbon, Shunsuke Teraguchi, Osamu Takeuchi, Yutaka Suzuki, Daron M. Standley Alexis Vandenbon, Shunsuke Teraguchi, Osamu Takeuchi, Yutaka Suzuki, Daron M. Standley Dynamics of enhancers in myeloid antigen presenting cells upon LPS stimulation Dynamics of enhancers in myeloid antigen presenting cells upon LPS stimulation Dynamics of enhancers in myeloid antigen presenting cells upon LPS stimulation BMC Genomics, 15, S4 BMC Genomics, 15, S4 BMC Genomics, 15, S4 2014 英語 研究論文(学術雑誌) 公開
Munenori Yokota, Shoji Yoshida, Yutaka Mera, Osamu Takeuchi, Haruhiro Oigawa, Hidemi Shigekawa Munenori Yokota, Shoji Yoshida, Yutaka Mera, Osamu Takeuchi, Haruhiro Oigawa, Hidemi Shigekawa Munenori Yokota, Shoji Yoshida, Yutaka Mera, Osamu Takeuchi, Haruhiro Oigawa, Hidemi Shigekawa Bases for time-resolved probing of transient carrier dynamics by optical pump-probe scanning tunneling microscopy. Bases for time-resolved probing of transient carrier dynamics by optical pump-probe scanning tunneling microscopy. Bases for time-resolved probing of transient carrier dynamics by optical pump-probe scanning tunneling microscopy. Nanoscale, 5, 19, 9170-5 Nanoscale, 5, 19, 9170-5 Nanoscale, 5, 19, 9170-5 2013/10/07 英語 公開
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Hilary Sandig, Catherine E. Jobbings, Nestor Gonzalez Roldan, Jayde K. Whittingham-Dowd, Zane Orinska, Osamu Takeuchi, Shizuo Akira, Silvia Bulfone-Paus Hilary Sandig, Catherine E. Jobbings, Nestor Gonzalez Roldan, Jayde K. Whittingham-Dowd, Zane Orinska, Osamu Takeuchi, Shizuo Akira, Silvia Bulfone-Paus Hilary Sandig, Catherine E. Jobbings, Nestor Gonzalez Roldan, Jayde K. Whittingham-Dowd, Zane Orinska, Osamu Takeuchi, Shizuo Akira, Silvia Bulfone-Paus IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation European Journal of Immunology, 43, 4, 979-988 European Journal of Immunology, 43, 4, 979-988 European Journal of Immunology, 43, 4, 979-988 2013/04 英語 研究論文(学術雑誌) 公開
Daisuke Ori, Hiroki Kato, Hideki Sanjo, Sarang Tartey, Takashi Mino, Shizuo Akira, Osamu Takeuchi Daisuke Ori, Hiroki Kato, Hideki Sanjo, Sarang Tartey, Takashi Mino, Shizuo Akira, Osamu Takeuchi Daisuke Ori, Hiroki Kato, Hideki Sanjo, Sarang Tartey, Takashi Mino, Shizuo Akira, Osamu Takeuchi Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs Journal of Immunology, 190, 8, 4037-4045 Journal of Immunology, 190, 8, 4037-4045 Journal of Immunology, 190, 8, 4037-4045 2013/04 英語 研究論文(学術雑誌) 公開
Takashi Satoh, Hiroyasu Kidoya, Hisamichi Naito, Masahiro Yamamoto, Naoki Takemura, Katsuhiro Nakagawa, Yoshichika Yoshioka, Eiichi Morii, Nobuyuki Takakura, Osamu Takeuchi, Shizuo Akira Takashi Satoh, Hiroyasu Kidoya, Hisamichi Naito, Masahiro Yamamoto, Naoki Takemura, Katsuhiro Nakagawa, Yoshichika Yoshioka, Eiichi Morii, Nobuyuki Takakura, Osamu Takeuchi, Shizuo Akira Takashi Satoh, Hiroyasu Kidoya, Hisamichi Naito, Masahiro Yamamoto, Naoki Takemura, Katsuhiro Nakagawa, Yoshichika Yoshioka, Eiichi Morii, Nobuyuki Takakura, Osamu Takeuchi, Shizuo Akira Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages Nature, 495, 7442, 524-528 Nature, 495, 7442, 524-528 Nature, 495, 7442, 524-528 2013/03/28 英語 研究論文(学術雑誌) 公開
H. Kumar, O. Takeuchi, S. Akira H. Kumar, O. Takeuchi, S. Akira H. Kumar, O. Takeuchi, S. Akira Toll-Like Receptors Toll-Like Receptors Toll-Like Receptors Encyclopedia of Biological Chemistry: Second Edition, 396-401 Encyclopedia of Biological Chemistry: Second Edition, 396-401 Encyclopedia of Biological Chemistry: Second Edition, 396-401 2013/02/15 公開
Kenta Maruyama, Satoshi Uematsu, Takeshi Kondo, Osamu Takeuchi, Mikaël M. Martino, Takumi Kawasaki, Shizuo Akira Kenta Maruyama, Satoshi Uematsu, Takeshi Kondo, Osamu Takeuchi, Mikaël M. Martino, Takumi Kawasaki, Shizuo Akira Kenta Maruyama, Satoshi Uematsu, Takeshi Kondo, Osamu Takeuchi, Mikaël M. Martino, Takumi Kawasaki, Shizuo Akira Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP Journal of Experimental Medicine, 210, 10, 1947-1960 Journal of Experimental Medicine, 210, 10, 1947-1960 Journal of Experimental Medicine, 210, 10, 1947-1960 2013 英語 研究論文(学術雑誌) 公開
Takashi Mino, Osamu Takeuchi Takashi Mino, Osamu Takeuchi Takashi Mino, Osamu Takeuchi Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation Biotechnology and Genetic Engineering Reviews, 29, 1, 49-60 Biotechnology and Genetic Engineering Reviews, 29, 1, 49-60 Biotechnology and Genetic Engineering Reviews, 29, 1, 49-60 2013 英語 研究論文(学術雑誌) 公開
Kenta Maruyama, Masahiro Fukasaka, Alexis Vandenbon, Tatsuya Saitoh, Takumi Kawasaki, Takeshi Kondo, Kazunari K. Yokoyama, Hiroyasu Kidoya, Nobuyuki Takakura, Daron Standley, Osamu Takeuchi, Shizuo Akira Kenta Maruyama, Masahiro Fukasaka, Alexis Vandenbon, Tatsuya Saitoh, Takumi Kawasaki, Takeshi Kondo, Kazunari K. Yokoyama, Hiroyasu Kidoya, Nobuyuki Takakura, Daron Standley, Osamu Takeuchi, Shizuo Akira Kenta Maruyama, Masahiro Fukasaka, Alexis Vandenbon, Tatsuya Saitoh, Takumi Kawasaki, Takeshi Kondo, Kazunari K. Yokoyama, Hiroyasu Kidoya, Nobuyuki Takakura, Daron Standley, Osamu Takeuchi, Shizuo Akira The Transcription Factor Jdp2 Controls Bone Homeostasis and Antibacterial Immunity by Regulating Osteoclast and Neutrophil Differentiation The Transcription Factor Jdp2 Controls Bone Homeostasis and Antibacterial Immunity by Regulating Osteoclast and Neutrophil Differentiation The Transcription Factor Jdp2 Controls Bone Homeostasis and Antibacterial Immunity by Regulating Osteoclast and Neutrophil Differentiation Immunity, 37, 6, 1024-1036 Immunity, 37, 6, 1024-1036 Immunity, 37, 6, 1024-1036 2012/12/14 英語 研究論文(学術雑誌) 公開
三野享史, 竹内理 三野享史, 竹内理 シグナル 自然免疫における転写後調節 シグナル 自然免疫における転写後調節 医学のあゆみ, 243, 1, 57-62 医学のあゆみ, 243, 1, 57-62 , 243, 1, 57-62 2012/10/06 日本語 公開
Maruyama K, Kawagoe T, Kondo T, Akira S, Takeuchi O Maruyama K, Kawagoe T, Kondo T, Akira S, Takeuchi O Kenta Maruyama, Tatsukata Kawagoe, Takeshi Kondo, Shizuo Akira, Osamu Takeuchi TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation. TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation. TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation The Journal of biological chemistry, 287, 34, 29114-29124 The Journal of biological chemistry, 287, 34, 29114-29124 Journal of Biological Chemistry, 287, 34, 29114-29124 2012/08/17 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi Osamu Takeuchi Osamu Takeuchi IRF3: A molecular switch in pathogen responses IRF3: A molecular switch in pathogen responses IRF3: A molecular switch in pathogen responses Nature Immunology, 13, 7, 634-635 Nature Immunology, 13, 7, 634-635 Nature Immunology, 13, 7, 634-635 2012/07 英語 公開
Takayuki Abe, Takasuke Fukuhara, Xiauyu Wen, Akinori Ninomiya, Kohji Moriishi, Yoshihiko Maehara, Osamu Takeuchi, Taro Kawai, Shizuo Akira, Yoshiharu Matsuura Takayuki Abe, Takasuke Fukuhara, Xiauyu Wen, Akinori Ninomiya, Kohji Moriishi, Yoshihiko Maehara, Osamu Takeuchi, Taro Kawai, Shizuo Akira, Yoshiharu Matsuura Takayuki Abe, Takasuke Fukuhara, Xiauyu Wen, Akinori Ninomiya, Kohji Moriishi, Yoshihiko Maehara, Osamu Takeuchi, Taro Kawai, Shizuo Akira, Yoshiharu Matsuura CD44 Participates in IP-10 Induction in Cells in Which Hepatitis C Virus RNA Is Replicating, through an Interaction with Toll-Like Receptor 2 and Hyaluronan CD44 Participates in IP-10 Induction in Cells in Which Hepatitis C Virus RNA Is Replicating, through an Interaction with Toll-Like Receptor 2 and Hyaluronan CD44 Participates in IP-10 Induction in Cells in Which Hepatitis C Virus RNA Is Replicating, through an Interaction with Toll-Like Receptor 2 and Hyaluronan Journal of Virology, 86, 11, 6159-6170 Journal of Virology, 86, 11, 6159-6170 Journal of Virology, 86, 11, 6159-6170 2012/06 英語 研究論文(学術雑誌) 公開
Andrea Schuessler, Anneke Funk, Helen M. Lazear, Daphne A. Cooper, Shessy Torres, Stephane Daffis, Babal Kant Jha, Yutaro Kumagai, Osamu Takeuchi, Paul Hertzog, Robert Silverman, Shizuo Akira, David J. Barton, Michael S. Diamond, Alexander A. Khromykh Andrea Schuessler, Anneke Funk, Helen M. Lazear, Daphne A. Cooper, Shessy Torres, Stephane Daffis, Babal Kant Jha, Yutaro Kumagai, Osamu Takeuchi, Paul Hertzog, Robert Silverman, Shizuo Akira, David J. Barton, Michael S. Diamond, Alexander A. Khromykh Andrea Schuessler, Anneke Funk, Helen M. Lazear, Daphne A. Cooper, Shessy Torres, Stephane Daffis, Babal Kant Jha, Yutaro Kumagai, Osamu Takeuchi, Paul Hertzog, Robert Silverman, Shizuo Akira, David J. Barton, Michael S. Diamond, Alexander A. Khromykh West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response Journal of Virology, 86, 10, 5708-5718 Journal of Virology, 86, 10, 5708-5718 Journal of Virology, 86, 10, 5708-5718 2012/05 英語 研究論文(学術雑誌) 公開
Sachin D. Deshmukh, Sabrina Müller, Katrin Hese, Katharina S. Rauch, Julia Wennekamp, Osamu Takeuchi, Shizuo Akira, Douglas T. Golenbock, Philipp Henneke Sachin D. Deshmukh, Sabrina Müller, Katrin Hese, Katharina S. Rauch, Julia Wennekamp, Osamu Takeuchi, Shizuo Akira, Douglas T. Golenbock, Philipp Henneke Sachin D. Deshmukh, Sabrina Müller, Katrin Hese, Katharina S. Rauch, Julia Wennekamp, Osamu Takeuchi, Shizuo Akira, Douglas T. Golenbock, Philipp Henneke NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA Journal of Immunology, 188, 2, 774-780 Journal of Immunology, 188, 2, 774-780 Journal of Immunology, 188, 2, 774-780 2012/01/15 英語 研究論文(学術雑誌) 公開
Takeuchi O, Akira S Takeuchi O, Akira S Takeuchi O, Akira S Contribution of LGP2 to Viral Recognition Pathways. Contribution of LGP2 to Viral Recognition Pathways. Contribution of LGP2 to Viral Recognition Pathways. Nucleic Acid Sensors and Antiviral Immunity, Landes Bioscience, 2012. Nucleic Acid Sensors and Antiviral Immunity, Landes Bioscience, 2012. Nucleic Acid Sensors and Antiviral Immunity, Landes Bioscience, 2012. 2012 英語 公開
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Sun Myung Joung, Zee Yong Park, Shilpa Rani, Osamu Takeuchi, Shizuo Akira, Joo Young Lee Sun Myung Joung, Zee Yong Park, Shilpa Rani, Osamu Takeuchi, Shizuo Akira, Joo Young Lee Sun Myung Joung, Zee Yong Park, Shilpa Rani, Osamu Takeuchi, Shizuo Akira, Joo Young Lee Akt contributes to activation of the TRIF-dependent signaling pathways of TLRS by interacting with TANK-binding kinase 1 Akt contributes to activation of the TRIF-dependent signaling pathways of TLRS by interacting with TANK-binding kinase 1 Akt contributes to activation of the TRIF-dependent signaling pathways of TLRS by interacting with TANK-binding kinase 1 Journal of Immunology, 186, 1, 499-507 Journal of Immunology, 186, 1, 499-507 Journal of Immunology, 186, 1, 499-507 2011/01/01 英語 研究論文(学術雑誌) 公開
Decheng Ren, Ho Chou Tu, Hyungjin Kim, Gary X. Wang, Gregory R. Bean, Osamu Takeuchi, John R. Jeffers, Gerard P. Zambetti, James J.D. Hsieh, Emily H.Y. Cheng Decheng Ren, Ho Chou Tu, Hyungjin Kim, Gary X. Wang, Gregory R. Bean, Osamu Takeuchi, John R. Jeffers, Gerard P. Zambetti, James J.D. Hsieh, Emily H.Y. Cheng Decheng Ren, Ho Chou Tu, Hyungjin Kim, Gary X. Wang, Gregory R. Bean, Osamu Takeuchi, John R. Jeffers, Gerard P. Zambetti, James J.D. Hsieh, Emily H.Y. Cheng BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program Science, 330, 6009, 1390-1393 Science, 330, 6009, 1390-1393 Science, 330, 6009, 1390-1393 2010/12/03 英語 研究論文(学術雑誌) 公開
Shuhei Hashiguchi, Yuya Yamaguchi, Osamu Takeuchi, Shizuo Akira, Kazuhisa Sugimura Shuhei Hashiguchi, Yuya Yamaguchi, Osamu Takeuchi, Shizuo Akira, Kazuhisa Sugimura Shuhei Hashiguchi, Yuya Yamaguchi, Osamu Takeuchi, Shizuo Akira, Kazuhisa Sugimura Immunological basis of M13 phage vaccine: Regulation under MyD88 and TLR9 signaling Immunological basis of M13 phage vaccine: Regulation under MyD88 and TLR9 signaling Immunological basis of M13 phage vaccine: Regulation under MyD88 and TLR9 signaling Biochemical and Biophysical Research Communications, 402, 1, 19-22 Biochemical and Biophysical Research Communications, 402, 1, 19-22 Biochemical and Biophysical Research Communications, 402, 1, 19-22 2010/11/05 英語 研究論文(学術雑誌) 公開
Shizuo Akira, Tatsuya Saitoh, Kazufumi Matsushita, Osamu Takeuchi Shizuo Akira, Tatsuya Saitoh, Kazufumi Matsushita, Osamu Takeuchi Shizuo Akira, Tatsuya Saitoh, Kazufumi Matsushita, Osamu Takeuchi Negative regulators in toll-like receptor responses Negative regulators in toll-like receptor responses Negative regulators in toll-like receptor responses Cornea, 29, SUPPL. 1, S13-9 Cornea, 29, SUPPL. 1, S13-9 Cornea, 29, SUPPL. 1, S13-9 2010/11 英語 研究論文(国際会議プロシーディングス) 公開
Takashi Satoh, Osamu Takeuchi, Alexis Vandenbon, Koubun Yasuda, Yoshiaki Tanaka, Yutaro Kumagai, Tohru Miyake, Kazufumi Matsushita, Toshihiko Okazaki, Tatsuya Saitoh, Kiri Honma, Toshifumi Matsuyama, Katsuyuki Yui, Tohru Tsujimura, Daron M. Standley, Kenji Nakanishi, Kenta Nakai, Shizuo Akira Takashi Satoh, Osamu Takeuchi, Alexis Vandenbon, Koubun Yasuda, Yoshiaki Tanaka, Yutaro Kumagai, Tohru Miyake, Kazufumi Matsushita, Toshihiko Okazaki, Tatsuya Saitoh, Kiri Honma, Toshifumi Matsuyama, Katsuyuki Yui, Tohru Tsujimura, Daron M. Standley, Kenji Nakanishi, Kenta Nakai, Shizuo Akira Takashi Satoh, Osamu Takeuchi, Alexis Vandenbon, Koubun Yasuda, Yoshiaki Tanaka, Yutaro Kumagai, Tohru Miyake, Kazufumi Matsushita, Toshihiko Okazaki, Tatsuya Saitoh, Kiri Honma, Toshifumi Matsuyama, Katsuyuki Yui, Tohru Tsujimura, Daron M. Standley, Kenji Nakanishi, Kenta Nakai, Shizuo Akira The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection Nature Immunology, 11, 10, 936-944 Nature Immunology, 11, 10, 936-944 Nature Immunology, 11, 10, 936-944 2010/10 英語 研究論文(学術雑誌) 公開
Oliver Schulz, Andreas Pichlmair, Jan Rehwinkel, Neil C. Rogers, Donalyn Scheuner, Hiroki Kato, Osamu Takeuchi, Shizuo Akira, Randal J. Kaufman, Caetano Reis E Sousa Oliver Schulz, Andreas Pichlmair, Jan Rehwinkel, Neil C. Rogers, Donalyn Scheuner, Hiroki Kato, Osamu Takeuchi, Shizuo Akira, Randal J. Kaufman, Caetano Reis E Sousa Oliver Schulz, Andreas Pichlmair, Jan Rehwinkel, Neil C. Rogers, Donalyn Scheuner, Hiroki Kato, Osamu Takeuchi, Shizuo Akira, Randal J. Kaufman, Caetano Reis E Sousa Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity Cell Host and Microbe, 7, 5, 354-361 Cell Host and Microbe, 7, 5, 354-361 Cell Host and Microbe, 7, 5, 354-361 2010/05/20 英語 研究論文(学術雑誌) 公開
Ken Ando, Keiichi Hasegawa, Ken Ichi Shindo, Tomoyasu Furusawa, Tomofumi Fujino, Kiyomi Kikugawa, Hiroyasu Nakano, Osamu Takeuchi, Shizuo Akira, Taishin Akiyama, Jin Gohda, Jun Ichiro Inoue, Makio Hayakawa Ken Ando, Keiichi Hasegawa, Ken Ichi Shindo, Tomoyasu Furusawa, Tomofumi Fujino, Kiyomi Kikugawa, Hiroyasu Nakano, Osamu Takeuchi, Shizuo Akira, Taishin Akiyama, Jin Gohda, Jun Ichiro Inoue, Makio Hayakawa Ken Ando, Keiichi Hasegawa, Ken Ichi Shindo, Tomoyasu Furusawa, Tomofumi Fujino, Kiyomi Kikugawa, Hiroyasu Nakano, Osamu Takeuchi, Shizuo Akira, Taishin Akiyama, Jin Gohda, Jun Ichiro Inoue, Makio Hayakawa Human lactoferrin activates NF-κB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling Human lactoferrin activates NF-κB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling Human lactoferrin activates NF-κB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling FEBS Journal, 277, 9, 2051-2066 FEBS Journal, 277, 9, 2051-2066 FEBS Journal, 277, 9, 2051-2066 2010/05 英語 研究論文(学術雑誌) 公開
三宅 亨, 竹内 理, 審良 静男 三宅 亨, 竹内 理, 審良 静男 三宅 亨, 竹内 理, 審良 静男 自然免疫における臨床展望 自然免疫における臨床展望 自然免疫における臨床展望 Medical Practice, 27, 5, 876-878 Medical Practice, 27, 5, 876-878 Medical Practice, 27, 5, 876-878 2010/05 日本語 公開
Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Pattern Recognition Receptors and Inflammation Pattern Recognition Receptors and Inflammation Pattern Recognition Receptors and Inflammation Cell, 140, 6, 805-820 Cell, 140, 6, 805-820 Cell, 140, 6, 805-820 2010/03 英語 公開
Osamu Takeuchi Osamu Takeuchi Osamu Takeuchi Regulation of immune responses by mRNA stability control Regulation of immune responses by mRNA stability control Regulation of immune responses by mRNA stability control Seikagaku, 82, 12, 1124-1128 Seikagaku, 82, 12, 1124-1128 Seikagaku, 82, 12, 1124-1128 2010 英語 研究論文(学術雑誌) 公開
Hiroyuki Oshiumi, Masanori Ikeda, Misako Matsumoto, Ayako Watanabe, Osamu Takeuchi, Shizuo Akira, Nobuyuki Kato, Kunitada Shimotohno, Tsukasa Seya Hiroyuki Oshiumi, Masanori Ikeda, Misako Matsumoto, Ayako Watanabe, Osamu Takeuchi, Shizuo Akira, Nobuyuki Kato, Kunitada Shimotohno, Tsukasa Seya Hiroyuki Oshiumi, Masanori Ikeda, Misako Matsumoto, Ayako Watanabe, Osamu Takeuchi, Shizuo Akira, Nobuyuki Kato, Kunitada Shimotohno, Tsukasa Seya Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction PLoS ONE, 5, 12, e14258 PLoS ONE, 5, 12, e14258 PLoS ONE, 5, 12, e14258 2010 英語 研究論文(学術雑誌) 公開
Michael Berger, Philippe Krebs, Karine Crozat, Xiaohong Li, Ben A. Croker, Owen M. Siggs, Daniel Popkin, Xin Du, Brian R. Lawson, Argyrios N. Theofilopoulos, Yu Xia, Kevin Khovananth, Eva Marie Y. Moresco, Takashi Satoh, Osamu Takeuchi, Shizuo Akira, Bruce Beutler Michael Berger, Philippe Krebs, Karine Crozat, Xiaohong Li, Ben A. Croker, Owen M. Siggs, Daniel Popkin, Xin Du, Brian R. Lawson, Argyrios N. Theofilopoulos, Yu Xia, Kevin Khovananth, Eva Marie Y. Moresco, Takashi Satoh, Osamu Takeuchi, Shizuo Akira, Bruce Beutler Michael Berger, Philippe Krebs, Karine Crozat, Xiaohong Li, Ben A. Croker, Owen M. Siggs, Daniel Popkin, Xin Du, Brian R. Lawson, Argyrios N. Theofilopoulos, Yu Xia, Kevin Khovananth, Eva Marie Y. Moresco, Takashi Satoh, Osamu Takeuchi, Shizuo Akira, Bruce Beutler An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence Nature Immunology, 11, 4, 335-343 Nature Immunology, 11, 4, 335-343 Nature Immunology, 11, 4, 335-343 2010 英語 研究論文(学術雑誌) 公開
David G. Kirsch, Philip M. Santiago, Emmanuelle Di Tomaso, Julie M. Sullivan, Wu Shiun Hou, Talya Dayton, Laura B. Jeffords, Pooja Sodha, Kim L. Mercer, Rhianna Cohen, Osamu Takeuchi, Stanley J. Korsmeyer, Roderick T. Bronson, Carla F. Kim, Kevin M. Haigis, Rakesh K. Jain, Tyler Jacks David G. Kirsch, Philip M. Santiago, Emmanuelle Di Tomaso, Julie M. Sullivan, Wu Shiun Hou, Talya Dayton, Laura B. Jeffords, Pooja Sodha, Kim L. Mercer, Rhianna Cohen, Osamu Takeuchi, Stanley J. Korsmeyer, Roderick T. Bronson, Carla F. Kim, Kevin M. Haigis, Rakesh K. Jain, Tyler Jacks David G. Kirsch, Philip M. Santiago, Emmanuelle Di Tomaso, Julie M. Sullivan, Wu Shiun Hou, Talya Dayton, Laura B. Jeffords, Pooja Sodha, Kim L. Mercer, Rhianna Cohen, Osamu Takeuchi, Stanley J. Korsmeyer, Roderick T. Bronson, Carla F. Kim, Kevin M. Haigis, Rakesh K. Jain, Tyler Jacks P53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis P53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis P53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis Science, 327, 5965, 593-596 Science, 327, 5965, 593-596 Science, 327, 5965, 593-596 2010 英語 研究論文(学術雑誌) 公開
Eri Ishikawa, Tetsuaki Ishikawa, Yasu S. Morita, Kenji Toyonaga, Hisakata Yamada, Osamu Takeuchi, Taroh Kinoshita, Shizuo Akira, Yasunobu Yoshikai, Sho Yamasaki Eri Ishikawa, Tetsuaki Ishikawa, Yasu S. Morita, Kenji Toyonaga, Hisakata Yamada, Osamu Takeuchi, Taroh Kinoshita, Shizuo Akira, Yasunobu Yoshikai, Sho Yamasaki Eri Ishikawa, Tetsuaki Ishikawa, Yasu S. Morita, Kenji Toyonaga, Hisakata Yamada, Osamu Takeuchi, Taroh Kinoshita, Shizuo Akira, Yasunobu Yoshikai, Sho Yamasaki Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle Journal of Experimental Medicine, 206, 13, 2879-2888 Journal of Experimental Medicine, 206, 13, 2879-2888 Journal of Experimental Medicine, 206, 13, 2879-2888 2009/12/21 英語 研究論文(学術雑誌) 公開
Hyungjin Kim, Ho Chou Tu, Decheng Ren, Osamu Takeuchi, John R. Jeffers, Gerard P. Zambetti, James J.D. Hsieh, Emily H.Y. Cheng Hyungjin Kim, Ho Chou Tu, Decheng Ren, Osamu Takeuchi, John R. Jeffers, Gerard P. Zambetti, James J.D. Hsieh, Emily H.Y. Cheng Hyungjin Kim, Ho Chou Tu, Decheng Ren, Osamu Takeuchi, John R. Jeffers, Gerard P. Zambetti, James J.D. Hsieh, Emily H.Y. Cheng Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis Molecular Cell, 36, 3, 487-499 Molecular Cell, 36, 3, 487-499 Molecular Cell, 36, 3, 487-499 2009/11/13 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi, Kazufumi Matsushita, Shizuo Akira Osamu Takeuchi, Kazufumi Matsushita, Shizuo Akira Osamu Takeuchi, Kazufumi Matsushita, Shizuo Akira Control of inflammatory responses by a novel RNase, Zc3h12a Control of inflammatory responses by a novel RNase, Zc3h12a Control of inflammatory responses by a novel RNase, Zc3h12a Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 14, 1837-1841 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 14, 1837-1841 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 14, 1837-1841 2009/11 公開
Andreas Pichlmair, Oliver Schulz, Choon Ping Tan, Jan Rehwinkel, Hiroki Kato, Osamu Takeuchi, Shizuo Akira, Michael Way, Giampietro Schiavo, Caetano Reis E Sousa Andreas Pichlmair, Oliver Schulz, Choon Ping Tan, Jan Rehwinkel, Hiroki Kato, Osamu Takeuchi, Shizuo Akira, Michael Way, Giampietro Schiavo, Caetano Reis E Sousa Andreas Pichlmair, Oliver Schulz, Choon Ping Tan, Jan Rehwinkel, Hiroki Kato, Osamu Takeuchi, Shizuo Akira, Michael Way, Giampietro Schiavo, Caetano Reis E Sousa Activation of MDA5 requires higher-order RNA structures generated during virus infection Activation of MDA5 requires higher-order RNA structures generated during virus infection Activation of MDA5 requires higher-order RNA structures generated during virus infection Journal of Virology, 83, 20, 10761-10769 Journal of Virology, 83, 20, 10761-10769 Journal of Virology, 83, 20, 10761-10769 2009/10 英語 研究論文(学術雑誌) 公開
Tohru Miyake, Yutaro Kumagai, Hiroki Kato, Zijin Guo, Kazufumi Matsushita, Takashi Satoh, Tatsukata Kawagoe, Himanshu Kumar, Myoung Ho Jang, Taro Kawai, Tohru Tani, Osamu Takeuchi, Shizuo Akira Tohru Miyake, Yutaro Kumagai, Hiroki Kato, Zijin Guo, Kazufumi Matsushita, Takashi Satoh, Tatsukata Kawagoe, Himanshu Kumar, Myoung Ho Jang, Taro Kawai, Tohru Tani, Osamu Takeuchi, Shizuo Akira Tohru Miyake, Yutaro Kumagai, Hiroki Kato, Zijin Guo, Kazufumi Matsushita, Takashi Satoh, Tatsukata Kawagoe, Himanshu Kumar, Myoung Ho Jang, Taro Kawai, Tohru Tani, Osamu Takeuchi, Shizuo Akira Poly I:C-induced activation of NK cells by CD8α<sup>+</sup> dendritic cells via the IPS-1 and TRIF-dependent pathways Poly I:C-induced activation of NK cells by CD8α<sup>+</sup> dendritic cells via the IPS-1 and TRIF-dependent pathways Poly I:C-induced activation of NK cells by CD8α<sup>+</sup> dendritic cells via the IPS-1 and TRIF-dependent pathways Journal of Immunology, 183, 4, 2522-2528 Journal of Immunology, 183, 4, 2522-2528 Journal of Immunology, 183, 4, 2522-2528 2009/08/15 英語 研究論文(学術雑誌) 公開
Takayuki Abe, Yuuki Kaname, Xiaoyu Wen, Hideki Tani, Kohji Moriishi, Satoshi Uematsu, Osamu Takeuchi, Ken J. Ishii, Taro Kawai, Shizuo Akira, Yoshiharu Matsuura Takayuki Abe, Yuuki Kaname, Xiaoyu Wen, Hideki Tani, Kohji Moriishi, Satoshi Uematsu, Osamu Takeuchi, Ken J. Ishii, Taro Kawai, Shizuo Akira, Yoshiharu Matsuura Takayuki Abe, Yuuki Kaname, Xiaoyu Wen, Hideki Tani, Kohji Moriishi, Satoshi Uematsu, Osamu Takeuchi, Ken J. Ishii, Taro Kawai, Shizuo Akira, Yoshiharu Matsuura Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner Journal of Virology, 83, 15, 7629-7640 Journal of Virology, 83, 15, 7629-7640 Journal of Virology, 83, 15, 7629-7640 2009/08 英語 研究論文(学術雑誌) 公開
Martin Schlee, Andreas Roth, Veit Hornung, Cristina Amparo Hagmann, Vera Wimmenauer, Winfried Barchet, Christoph Coch, Markus Janke, Aleksandra Mihailovic, Greg Wardle, Stefan Juranek, Hiroki Kato, Taro Kawai, Hendrik Poeck, Katherine A. Fitzgerald, Osamu Takeuchi, Shizuo Akira, Thomas Tuschl, Eicke Latz, Janos Ludwig, Gunther Hartmann Martin Schlee, Andreas Roth, Veit Hornung, Cristina Amparo Hagmann, Vera Wimmenauer, Winfried Barchet, Christoph Coch, Markus Janke, Aleksandra Mihailovic, Greg Wardle, Stefan Juranek, Hiroki Kato, Taro Kawai, Hendrik Poeck, Katherine A. Fitzgerald, Osamu Takeuchi, Shizuo Akira, Thomas Tuschl, Eicke Latz, Janos Ludwig, Gunther Hartmann Martin Schlee, Andreas Roth, Veit Hornung, Cristina Amparo Hagmann, Vera Wimmenauer, Winfried Barchet, Christoph Coch, Markus Janke, Aleksandra Mihailovic, Greg Wardle, Stefan Juranek, Hiroki Kato, Taro Kawai, Hendrik Poeck, Katherine A. Fitzgerald, Osamu Takeuchi, Shizuo Akira, Thomas Tuschl, Eicke Latz, Janos Ludwig, Gunther Hartmann Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus Immunity, 31, 1, 25-34 Immunity, 31, 1, 25-34 Immunity, 31, 1, 25-34 2009/07/17 英語 研究論文(学術雑誌) 公開
Hiroyasu Konno, Takuya Yamamoto, Kohsuke Yamazaki, Jin Gohda, Taishin Akiyama, Kentaro Semba, Hideo Goto, Atsushi Kato, Toshiaki Yujiri, Takahiko Imai, Yasushi Kawaguchi, Bing Su, Osamu Takeuchi, Shizuo Akira, Yasuko Tsunetsugu-Yokota, Jun Ichiro Inoue Hiroyasu Konno, Takuya Yamamoto, Kohsuke Yamazaki, Jin Gohda, Taishin Akiyama, Kentaro Semba, Hideo Goto, Atsushi Kato, Toshiaki Yujiri, Takahiko Imai, Yasushi Kawaguchi, Bing Su, Osamu Takeuchi, Shizuo Akira, Yasuko Tsunetsugu-Yokota, Jun Ichiro Inoue Hiroyasu Konno, Takuya Yamamoto, Kohsuke Yamazaki, Jin Gohda, Taishin Akiyama, Kentaro Semba, Hideo Goto, Atsushi Kato, Toshiaki Yujiri, Takahiko Imai, Yasushi Kawaguchi, Bing Su, Osamu Takeuchi, Shizuo Akira, Yasuko Tsunetsugu-Yokota, Jun Ichiro Inoue TRAF6 establishes innate immune responses by activating NF-κB and IRF7 upon sensing cytosolic viral RNA and DNA TRAF6 establishes innate immune responses by activating NF-κB and IRF7 upon sensing cytosolic viral RNA and DNA TRAF6 establishes innate immune responses by activating NF-κB and IRF7 upon sensing cytosolic viral RNA and DNA PLoS ONE, 4, 5, e5674 PLoS ONE, 4, 5, e5674 PLoS ONE, 4, 5, e5674 2009/05/25 英語 研究論文(学術雑誌) 公開
Kazufumi Matsushita, Osamu Takeuchi, Daron M. Standley, Yutaro Kumagai, Tatsukata Kawagoe, Tohru Miyake, Takashi Satoh, Hiroki Kato, Tohru Tsujimura, Haruki Nakamura, Shizuo Akira Kazufumi Matsushita, Osamu Takeuchi, Daron M. Standley, Yutaro Kumagai, Tatsukata Kawagoe, Tohru Miyake, Takashi Satoh, Hiroki Kato, Tohru Tsujimura, Haruki Nakamura, Shizuo Akira Kazufumi Matsushita, Osamu Takeuchi, Daron M. Standley, Yutaro Kumagai, Tatsukata Kawagoe, Tohru Miyake, Takashi Satoh, Hiroki Kato, Tohru Tsujimura, Haruki Nakamura, Shizuo Akira Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay Nature, 458, 7242, 1185-1190 Nature, 458, 7242, 1185-1190 Nature, 458, 7242, 1185-1190 2009/04 英語 研究論文(学術雑誌) 公開
Yutaro Kumagai, Himanshu Kumar, Shohei Koyama, Taro Kawai, Osamu Takeuchi, Shizuo Akira Yutaro Kumagai, Himanshu Kumar, Shohei Koyama, Taro Kawai, Osamu Takeuchi, Shizuo Akira Yutaro Kumagai, Himanshu Kumar, Shohei Koyama, Taro Kawai, Osamu Takeuchi, Shizuo Akira Cutting edge: TLR-dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-α production in plasmacytoid dendritic cells Cutting edge: TLR-dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-α production in plasmacytoid dendritic cells Cutting edge: TLR-dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-α production in plasmacytoid dendritic cells Journal of Immunology, 182, 7, 3960-3964 Journal of Immunology, 182, 7, 3960-3964 Journal of Immunology, 182, 7, 3960-3964 2009/04 英語 研究論文(学術雑誌) 公開
Kenji Kurokawa, Hanna Lee, Kyung Baeg Roh, Miwako Asanuma, Young Sook Kim, Hiroshi Nakayama, Akiko Shiratsuchi, Youngnim Choi, Osamu Takeuchi, Hee Jung Kang, Naoshi Dohmae, Yoshinobu Nakanishi, Shizuo Akira, Kazuhisa Sekimizu, Bok Luel Lee Kenji Kurokawa, Hanna Lee, Kyung Baeg Roh, Miwako Asanuma, Young Sook Kim, Hiroshi Nakayama, Akiko Shiratsuchi, Youngnim Choi, Osamu Takeuchi, Hee Jung Kang, Naoshi Dohmae, Yoshinobu Nakanishi, Shizuo Akira, Kazuhisa Sekimizu, Bok Luel Lee Kenji Kurokawa, Hanna Lee, Kyung Baeg Roh, Miwako Asanuma, Young Sook Kim, Hiroshi Nakayama, Akiko Shiratsuchi, Youngnim Choi, Osamu Takeuchi, Hee Jung Kang, Naoshi Dohmae, Yoshinobu Nakanishi, Shizuo Akira, Kazuhisa Sekimizu, Bok Luel Lee The triacylated ATP binding cluster transporter substrate-binding lipoprotein of Staphylococcus aureus functions as a native ligand for toll-like receptor 2 The triacylated ATP binding cluster transporter substrate-binding lipoprotein of Staphylococcus aureus functions as a native ligand for toll-like receptor 2 The triacylated ATP binding cluster transporter substrate-binding lipoprotein of Staphylococcus aureus functions as a native ligand for toll-like receptor 2 Journal of Biological Chemistry, 284, 13, 8406-8411 Journal of Biological Chemistry, 284, 13, 8406-8411 Journal of Biological Chemistry, 284, 13, 8406-8411 2009/03/27 英語 研究論文(学術雑誌) 公開
Desiree A. Steimer, Kelli Boyd, Osamu Takeuchi, Jill K. Fisher, Gerard P. Zambetti, Joseph T. Opferman Desiree A. Steimer, Kelli Boyd, Osamu Takeuchi, Jill K. Fisher, Gerard P. Zambetti, Joseph T. Opferman Desiree A. Steimer, Kelli Boyd, Osamu Takeuchi, Jill K. Fisher, Gerard P. Zambetti, Joseph T. Opferman Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function Blood, 113, 12, 2805-2815 Blood, 113, 12, 2805-2815 Blood, 113, 12, 2805-2815 2009/03/19 英語 研究論文(学術雑誌) 公開
Tatsukata Kawagoe, Osamu Takeuchi, Yoshitsugu Takabatake, Hiroki Kato, Yoshitaka Isaka, Tohru Tsujimura, Shizuo Akira Tatsukata Kawagoe, Osamu Takeuchi, Yoshitsugu Takabatake, Hiroki Kato, Yoshitaka Isaka, Tohru Tsujimura, Shizuo Akira Tatsukata Kawagoe, Osamu Takeuchi, Yoshitsugu Takabatake, Hiroki Kato, Yoshitaka Isaka, Tohru Tsujimura, Shizuo Akira TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis Nature Immunology, 10, 9, 965-972 Nature Immunology, 10, 9, 965-972 Nature Immunology, 10, 9, 965-972 2009 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Innate immunity to virus infection Innate immunity to virus infection Innate immunity to virus infection Immunological Reviews, 227, 1, 75-86 Immunological Reviews, 227, 1, 75-86 Immunological Reviews, 227, 1, 75-86 2009/01 英語 公開
Pui Y. Lee, Yutaro Kumagai, Yi Li, Osamu Takeuchi, Hideo Yoshida, Jason Weinstein, Erinn S. Kellner, Dina Nacionales, Tolga Barker, Kindra Kelly-Scumpia, Nico Van Rooijen, Himanshu Kumar, Taro Kawai, Minoru Satoh, Shizuo Akira, Westley H. Reeves Pui Y. Lee, Yutaro Kumagai, Yi Li, Osamu Takeuchi, Hideo Yoshida, Jason Weinstein, Erinn S. Kellner, Dina Nacionales, Tolga Barker, Kindra Kelly-Scumpia, Nico Van Rooijen, Himanshu Kumar, Taro Kawai, Minoru Satoh, Shizuo Akira, Westley H. Reeves Pui Y. Lee, Yutaro Kumagai, Yi Li, Osamu Takeuchi, Hideo Yoshida, Jason Weinstein, Erinn S. Kellner, Dina Nacionales, Tolga Barker, Kindra Kelly-Scumpia, Nico Van Rooijen, Himanshu Kumar, Taro Kawai, Minoru Satoh, Shizuo Akira, Westley H. Reeves TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus Journal of Experimental Medicine, 205, 13, 2995-3006 Journal of Experimental Medicine, 205, 13, 2995-3006 Journal of Experimental Medicine, 205, 13, 2995-3006 2008/12/22 英語 研究論文(学術雑誌) 公開
Tatsuya Saitoh, Naonobu Fujita, Myoung Ho Jang, Satoshi Uematsu, Bo Gie Yang, Takashi Satoh, Hiroko Omori, Takeshi Noda, Naoki Yamamoto, Masaaki Komatsu, Keiji Tanaka, Taro Kawai, Tohru Tsujimura, Osamu Takeuchi, Tamotsu Yoshimori, Shizuo Akira Tatsuya Saitoh, Naonobu Fujita, Myoung Ho Jang, Satoshi Uematsu, Bo Gie Yang, Takashi Satoh, Hiroko Omori, Takeshi Noda, Naoki Yamamoto, Masaaki Komatsu, Keiji Tanaka, Taro Kawai, Tohru Tsujimura, Osamu Takeuchi, Tamotsu Yoshimori, Shizuo Akira Tatsuya Saitoh, Naonobu Fujita, Myoung Ho Jang, Satoshi Uematsu, Bo Gie Yang, Takashi Satoh, Hiroko Omori, Takeshi Noda, Naoki Yamamoto, Masaaki Komatsu, Keiji Tanaka, Taro Kawai, Tohru Tsujimura, Osamu Takeuchi, Tamotsu Yoshimori, Shizuo Akira Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production Nature, 456, 7219, 264-268 Nature, 456, 7219, 264-268 Nature, 456, 7219, 264-268 2008/11/13 英語 研究論文(学術雑誌) 公開
Hiroki Kato, Osamu Takeuchi, Eriko Mikamo-Satoh, Reiko Hirai, Tomoji Kawai, Kazufumi Matsushita, Akane Hiiragi, Terence S. Dermody, Takashi Fujita, Shizuo Akira Hiroki Kato, Osamu Takeuchi, Eriko Mikamo-Satoh, Reiko Hirai, Tomoji Kawai, Kazufumi Matsushita, Akane Hiiragi, Terence S. Dermody, Takashi Fujita, Shizuo Akira Hiroki Kato, Osamu Takeuchi, Eriko Mikamo-Satoh, Reiko Hirai, Tomoji Kawai, Kazufumi Matsushita, Akane Hiiragi, Terence S. Dermody, Takashi Fujita, Shizuo Akira Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 Journal of Experimental Medicine, 205, 7, 1601-1610 Journal of Experimental Medicine, 205, 7, 1601-1610 Journal of Experimental Medicine, 205, 7, 1601-1610 2008/07/07 英語 研究論文(学術雑誌) 公開
Yuji Sakai, Toshio Tsuyuguchi, Tadashi Ohara, Seigo Yukisawa, Shin Tsuchiya, Harutoshi Sugiyama, Kaoru Miyakawa, Masamichi Ohbu, Kazuki Kato, Michio Kimura, Takashi Kaiho, Osamu Takeuchi, Osamu Matsuzaki, Masaru Miyazaki, Osamu Yokosuka Yuji Sakai, Toshio Tsuyuguchi, Tadashi Ohara, Seigo Yukisawa, Shin Tsuchiya, Harutoshi Sugiyama, Kaoru Miyakawa, Masamichi Ohbu, Kazuki Kato, Michio Kimura, Takashi Kaiho, Osamu Takeuchi, Osamu Matsuzaki, Masaru Miyazaki, Osamu Yokosuka Yuji Sakai, Toshio Tsuyuguchi, Tadashi Ohara, Seigo Yukisawa, Shin Tsuchiya, Harutoshi Sugiyama, Kaoru Miyakawa, Masamichi Ohbu, Kazuki Kato, Michio Kimura, Takashi Kaiho, Osamu Takeuchi, Osamu Matsuzaki, Masaru Miyazaki, Osamu Yokosuka A patient with adenocarcinoma of the jejunum successfully diagnosed by preoperative endoscopy for the small intestine A patient with adenocarcinoma of the jejunum successfully diagnosed by preoperative endoscopy for the small intestine A patient with adenocarcinoma of the jejunum successfully diagnosed by preoperative endoscopy for the small intestine HEPATO-GASTROENTEROLOGY, 55, 85, 1367-1369 HEPATO-GASTROENTEROLOGY, 55, 85, 1367-1369 HEPATO-GASTROENTEROLOGY, 55, 85, 1367-1369 2008/07 英語 研究論文(学術雑誌) 公開
Tatsukata Kawagoe, Shintaro Sato, Kazufumi Matsushita, Hiroki Kato, Kosuke Matsui, Yutaro Kumagai, Tatsuya Saitoh, Taro Kawai, Osamu Takeuchi, Shizuo Akira Tatsukata Kawagoe, Shintaro Sato, Kazufumi Matsushita, Hiroki Kato, Kosuke Matsui, Yutaro Kumagai, Tatsuya Saitoh, Taro Kawai, Osamu Takeuchi, Shizuo Akira Tatsukata Kawagoe, Shintaro Sato, Kazufumi Matsushita, Hiroki Kato, Kosuke Matsui, Yutaro Kumagai, Tatsuya Saitoh, Taro Kawai, Osamu Takeuchi, Shizuo Akira Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2 Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2 Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2 Nature Immunology, 9, 6, 684-691 Nature Immunology, 9, 6, 684-691 Nature Immunology, 9, 6, 684-691 2008/06 英語 研究論文(学術雑誌) 公開
Yutaro Kumagai, Osamu Takeuchi, Shizuo Akira Yutaro Kumagai, Osamu Takeuchi, Shizuo Akira Yutaro Kumagai, Osamu Takeuchi, Shizuo Akira Pathogen recognition by innate receptors Pathogen recognition by innate receptors Pathogen recognition by innate receptors Journal of Infection and Chemotherapy, 14, 2, 86-92 Journal of Infection and Chemotherapy, 14, 2, 86-92 Journal of Infection and Chemotherapy, 14, 2, 86-92 2008/04 英語 公開
Yutaro Kumagai, Osamu Takeuchi, Shizuo Akira Yutaro Kumagai, Osamu Takeuchi, Shizuo Akira Yutaro Kumagai, Osamu Takeuchi, Shizuo Akira TLR9 as a key receptor for the recognition of DNA TLR9 as a key receptor for the recognition of DNA TLR9 as a key receptor for the recognition of DNA Advanced Drug Delivery Reviews, 60, 7, 795-804 Advanced Drug Delivery Reviews, 60, 7, 795-804 Advanced Drug Delivery Reviews, 60, 7, 795-804 2008/04 英語 公開
Ken J. Ishii, Tatsukata Kawagoe, Shohei Koyama, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Satoshi Uematsu, Osamu Takeuchi, Fumihiko Takeshita, Cevayir Coban, Shizuo Akira Ken J. Ishii, Tatsukata Kawagoe, Shohei Koyama, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Satoshi Uematsu, Osamu Takeuchi, Fumihiko Takeshita, Cevayir Coban, Shizuo Akira Ken J. Ishii, Tatsukata Kawagoe, Shohei Koyama, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Satoshi Uematsu, Osamu Takeuchi, Fumihiko Takeshita, Cevayir Coban, Shizuo Akira TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines Nature, 451, 7179, 725-729 Nature, 451, 7179, 725-729 Nature, 451, 7179, 725-729 2008/02/07 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira MDA5/RIG-I and virus recognition MDA5/RIG-I and virus recognition MDA5/RIG-I and virus recognition Current Opinion in Immunology, 20, 1, 17-22 Current Opinion in Immunology, 20, 1, 17-22 Current Opinion in Immunology, 20, 1, 17-22 2008/02 英語 公開
Akira Goto, Kazufumi Matsushita, Viola Gesellchen, Laure El Chamy, David Kuttenkeuler, Osamu Takeuchi, Jules A. Hoffmann, Shizuo Akira, Michael Boutros, Jean-Marc Reichhart Akira Goto, Kazufumi Matsushita, Viola Gesellchen, Laure El Chamy, David Kuttenkeuler, Osamu Takeuchi, Jules A. Hoffmann, Shizuo Akira, Michael Boutros, Jean-Marc Reichhart Akira Goto, Kazufumi Matsushita, Viola Gesellchen, Laure El Chamy, David Kuttenkeuler, Osamu Takeuchi, Jules A. Hoffmann, Shizuo Akira, Michael Boutros, Jean-Marc Reichhart Corrigendum: Akirins are highly conserved nuclear proteins required for NF-kappa B-dependent gene expression in drosophila and mice (vol 9, pg 97, 2008) Corrigendum: Akirins are highly conserved nuclear proteins required for NF-kappa B-dependent gene expression in drosophila and mice (vol 9, pg 97, 2008) Corrigendum: Akirins are highly conserved nuclear proteins required for NF-kappa B-dependent gene expression in drosophila and mice (vol 9, pg 97, 2008) NATURE IMMUNOLOGY, 9, 2, 216-216 NATURE IMMUNOLOGY, 9, 2, 216-216 NATURE IMMUNOLOGY, 9, 2, 216-216 2008/02 英語 公開
Akira Goto, Kazufumi Matsushita, Viola Gesellchen, Laure El Chamy, David Kuttenkeuler, Osamu Takeuchi, Jules A. Hoffmann, Shizuo Akira, Michael Boutros, Jean Marc Reichhart Akira Goto, Kazufumi Matsushita, Viola Gesellchen, Laure El Chamy, David Kuttenkeuler, Osamu Takeuchi, Jules A. Hoffmann, Shizuo Akira, Michael Boutros, Jean Marc Reichhart Akira Goto, Kazufumi Matsushita, Viola Gesellchen, Laure El Chamy, David Kuttenkeuler, Osamu Takeuchi, Jules A. Hoffmann, Shizuo Akira, Michael Boutros, Jean Marc Reichhart Erratum: Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice (Nature Immunology (2008) vol. 9 (97-104) Erratum: Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice (Nature Immunology (2008) vol. 9 (97-104) Erratum: Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice (Nature Immunology (2008) vol. 9 (97-104) Nature Immunology, 9, 2, 216 Nature Immunology, 9, 2, 216 Nature Immunology, 9, 2, 216 2008/02 研究論文(学術雑誌) 公開
Rabindra N. Bhattacharjee, Kwon Sam Park, Xiuhao Chen, Tetsuya Iida, Takeshi Honda, Osamu Takeuchi, Shizuo Akira Rabindra N. Bhattacharjee, Kwon Sam Park, Xiuhao Chen, Tetsuya Iida, Takeshi Honda, Osamu Takeuchi, Shizuo Akira Rabindra N. Bhattacharjee, Kwon Sam Park, Xiuhao Chen, Tetsuya Iida, Takeshi Honda, Osamu Takeuchi, Shizuo Akira Translocation of VP1686 upregulates RhoB and accelerates phagocytic activity of macrophage through actin remodeling Translocation of VP1686 upregulates RhoB and accelerates phagocytic activity of macrophage through actin remodeling Translocation of VP1686 upregulates RhoB and accelerates phagocytic activity of macrophage through actin remodeling Journal of Microbiology and Biotechnology, 18, 1, 171-175 Journal of Microbiology and Biotechnology, 18, 1, 171-175 Journal of Microbiology and Biotechnology, 18, 1, 171-175 2008/01/28 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira RIG-I-like antiviral protein in flies RIG-I-like antiviral protein in flies RIG-I-like antiviral protein in flies Nature Immunology, 9, 12, 1327-1328 Nature Immunology, 9, 12, 1327-1328 Nature Immunology, 9, 12, 1327-1328 2008 英語 研究論文(学術雑誌) 公開
Akira Goto, Kazufumi Matsushita, Viola Gesellchen, Laure El Chamy, David Kuttenkeuler, Osamu Takeuchi, Jules A. Hoffmann, Shizuo Akira, Michael Boutros, Jean Marc Reichhart Akira Goto, Kazufumi Matsushita, Viola Gesellchen, Laure El Chamy, David Kuttenkeuler, Osamu Takeuchi, Jules A. Hoffmann, Shizuo Akira, Michael Boutros, Jean Marc Reichhart Akira Goto, Kazufumi Matsushita, Viola Gesellchen, Laure El Chamy, David Kuttenkeuler, Osamu Takeuchi, Jules A. Hoffmann, Shizuo Akira, Michael Boutros, Jean Marc Reichhart Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice Nature Immunology, 9, 1, 97-104 Nature Immunology, 9, 1, 97-104 Nature Immunology, 9, 1, 97-104 2008/01 英語 研究論文(学術雑誌) 公開
Andreas Jung, Hiroki Kato, Yutaro Kumagai, Himanshu Kumar, Taro Kawai, Osamu Takeuchi, Shizuo Akira Andreas Jung, Hiroki Kato, Yutaro Kumagai, Himanshu Kumar, Taro Kawai, Osamu Takeuchi, Shizuo Akira Andreas Jung, Hiroki Kato, Yutaro Kumagai, Himanshu Kumar, Taro Kawai, Osamu Takeuchi, Shizuo Akira Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88 Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88 Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88 Journal of Virology, 82, 1, 196-206 Journal of Virology, 82, 1, 196-206 Journal of Virology, 82, 1, 196-206 2008/01 英語 研究論文(学術雑誌) 公開
Hiroki Kato, Osamu Takeuchi Hiroki Kato, Osamu Takeuchi Hiroki Kato, Osamu Takeuchi Recognition of virus invasion by toll-like receptors and RIG-Ilike helicases Recognition of virus invasion by toll-like receptors and RIG-Ilike helicases Recognition of virus invasion by toll-like receptors and RIG-Ilike helicases Nucleic Acids in Innate Immunity, 31-42 Nucleic Acids in Innate Immunity, 31-42 Nucleic Acids in Innate Immunity, 31-42 2008/01/01 公開
Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Recognition of viruses by innate immunity Recognition of viruses by innate immunity Recognition of viruses by innate immunity Immunological Reviews, 220, 1, 214-224 Immunological Reviews, 220, 1, 214-224 Immunological Reviews, 220, 1, 214-224 2007/12 英語 公開
Bruce Beutler, Celine Eidenschenk, Karine Crozat, Jean Luc Imler, Osamu Takeuchi, Jules A. Hoffmann, Shizuo Akira Bruce Beutler, Celine Eidenschenk, Karine Crozat, Jean Luc Imler, Osamu Takeuchi, Jules A. Hoffmann, Shizuo Akira Bruce Beutler, Celine Eidenschenk, Karine Crozat, Jean Luc Imler, Osamu Takeuchi, Jules A. Hoffmann, Shizuo Akira Genetic analysis of resistance to viral infection Genetic analysis of resistance to viral infection Genetic analysis of resistance to viral infection Nature Reviews Immunology, 7, 10, 753-766 Nature Reviews Immunology, 7, 10, 753-766 Nature Reviews Immunology, 7, 10, 753-766 2007/10 英語 公開
Masahiro Yamamoto, Satoshi Uematsu, Toru Okamoto, Yoshiharu Matsuura, Shintaro Sato, Himanshu Kumar, Takashi Satoh, Tatsuya Saitoh, Kiyoshi Takeda, Ken J. Ishii, Osamu Takeuchi, Taro Kawai, Shizuo Akira Masahiro Yamamoto, Satoshi Uematsu, Toru Okamoto, Yoshiharu Matsuura, Shintaro Sato, Himanshu Kumar, Takashi Satoh, Tatsuya Saitoh, Kiyoshi Takeda, Ken J. Ishii, Osamu Takeuchi, Taro Kawai, Shizuo Akira Masahiro Yamamoto, Satoshi Uematsu, Toru Okamoto, Yoshiharu Matsuura, Shintaro Sato, Himanshu Kumar, Takashi Satoh, Tatsuya Saitoh, Kiyoshi Takeda, Ken J. Ishii, Osamu Takeuchi, Taro Kawai, Shizuo Akira Enhanced TLR-mediated NF-IL6-dependent gene expression by Trib1 deficiency Enhanced TLR-mediated NF-IL6-dependent gene expression by Trib1 deficiency Enhanced TLR-mediated NF-IL6-dependent gene expression by Trib1 deficiency Journal of Experimental Medicine, 204, 9, 2233-2239 Journal of Experimental Medicine, 204, 9, 2233-2239 Journal of Experimental Medicine, 204, 9, 2233-2239 2007/09/03 英語 研究論文(学術雑誌) 公開
Takayuki Abe, Yuuki Kaname, Itsuki Hamamoto, Yoshimi Tsuda, Xiaoyu Wen, Shuhei Taguwa, Kohji Moriishi, Osamu Takeuchi, Taro Kawai, Tatsuya Kanto, Norio Hayashi, Shizuo Akira, Yoshiharu Matsuura Takayuki Abe, Yuuki Kaname, Itsuki Hamamoto, Yoshimi Tsuda, Xiaoyu Wen, Shuhei Taguwa, Kohji Moriishi, Osamu Takeuchi, Taro Kawai, Tatsuya Kanto, Norio Hayashi, Shizuo Akira, Yoshiharu Matsuura Takayuki Abe, Yuuki Kaname, Itsuki Hamamoto, Yoshimi Tsuda, Xiaoyu Wen, Shuhei Taguwa, Kohji Moriishi, Osamu Takeuchi, Taro Kawai, Tatsuya Kanto, Norio Hayashi, Shizuo Akira, Yoshiharu Matsuura Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines Journal of Virology, 81, 17, 8953-8966 Journal of Virology, 81, 17, 8953-8966 Journal of Virology, 81, 17, 8953-8966 2007/09 英語 研究論文(学術雑誌) 公開
Yutaro Kumagai, Osamu Takeuchi, Hiroki Kato, Himanshu Kumar, Kosuke Matsui, Eiichi Morii, Katsuyuki Aozasa, Taro Kawai, Shizuo Akira Yutaro Kumagai, Osamu Takeuchi, Hiroki Kato, Himanshu Kumar, Kosuke Matsui, Eiichi Morii, Katsuyuki Aozasa, Taro Kawai, Shizuo Akira Yutaro Kumagai, Osamu Takeuchi, Hiroki Kato, Himanshu Kumar, Kosuke Matsui, Eiichi Morii, Katsuyuki Aozasa, Taro Kawai, Shizuo Akira Alveolar Macrophages Are the Primary Interferon-α Producer in Pulmonary Infection with RNA Viruses Alveolar Macrophages Are the Primary Interferon-α Producer in Pulmonary Infection with RNA Viruses Alveolar Macrophages Are the Primary Interferon-α Producer in Pulmonary Infection with RNA Viruses Immunity, 27, 2, 240-252 Immunity, 27, 2, 240-252 Immunity, 27, 2, 240-252 2007/08/24 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira TLR4 signaling: Negative regulation by degradation TLR4 signaling: Negative regulation by degradation TLR4 signaling: Negative regulation by degradation Blood, 110, 3, 794-794 Blood, 110, 3, 794-794 Blood, 110, 3, 794-794 2007/08/01 英語 公開
David G. Kirsch, Daniela M. Dinulescu, John B. Miller, Jan Grimm, Philip M. Santiago, Nathan P. Young, G. Petur Nielsen, Bradley J. Quade, Christopher J. Chaber, Christian P. Schultz, Osamu Takeuchi, Roderick T. Bronson, Denise Crowley, Stanley J. Korsmeyer, Sam S. Yoon, Francis J. Hornicek, Ralph Weissleder, Tyler Jacks David G. Kirsch, Daniela M. Dinulescu, John B. Miller, Jan Grimm, Philip M. Santiago, Nathan P. Young, G. Petur Nielsen, Bradley J. Quade, Christopher J. Chaber, Christian P. Schultz, Osamu Takeuchi, Roderick T. Bronson, Denise Crowley, Stanley J. Korsmeyer, Sam S. Yoon, Francis J. Hornicek, Ralph Weissleder, Tyler Jacks David G. Kirsch, Daniela M. Dinulescu, John B. Miller, Jan Grimm, Philip M. Santiago, Nathan P. Young, G. Petur Nielsen, Bradley J. Quade, Christopher J. Chaber, Christian P. Schultz, Osamu Takeuchi, Roderick T. Bronson, Denise Crowley, Stanley J. Korsmeyer, Sam S. Yoon, Francis J. Hornicek, Ralph Weissleder, Tyler Jacks A spatially and temporally restricted mouse model of soft tissue sarcoma A spatially and temporally restricted mouse model of soft tissue sarcoma A spatially and temporally restricted mouse model of soft tissue sarcoma Nature Medicine, 13, 8, 992-997 Nature Medicine, 13, 8, 992-997 Nature Medicine, 13, 8, 992-997 2007/08 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Pathogen recognition by innate immunity Pathogen recognition by innate immunity Pathogen recognition by innate immunity Arerugī = [Allergy], 56, 6, 558-562 Arerugī = [Allergy], 56, 6, 558-562 Arerugī = [Allergy], 56, 6, 558-562 2007/06 英語 公開
Tatsukata Kawagoe, Shintaro Sato, Andreas Jung, Masahiro Yamamoto, Kosuke Matsui, Hiroki Kato, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira Tatsukata Kawagoe, Shintaro Sato, Andreas Jung, Masahiro Yamamoto, Kosuke Matsui, Hiroki Kato, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira Tatsukata Kawagoe, Shintaro Sato, Andreas Jung, Masahiro Yamamoto, Kosuke Matsui, Hiroki Kato, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling Journal of Experimental Medicine, 204, 5, 1013-1024 Journal of Experimental Medicine, 204, 5, 1013-1024 Journal of Experimental Medicine, 204, 5, 1013-1024 2007/05 英語 研究論文(学術雑誌) 公開
Michaela U. Gack, Young C. Shin, Chul Hyun Joo, Tomohiko Urano, Chengyu Liang, Lijun Sun, Osamu Takeuchi, Shizuo Akira, Zhijian Chen, Satoshi Inoue, Jae U. Jung Michaela U. Gack, Young C. Shin, Chul Hyun Joo, Tomohiko Urano, Chengyu Liang, Lijun Sun, Osamu Takeuchi, Shizuo Akira, Zhijian Chen, Satoshi Inoue, Jae U. Jung Michaela U. Gack, Young C. Shin, Chul Hyun Joo, Tomohiko Urano, Chengyu Liang, Lijun Sun, Osamu Takeuchi, Shizuo Akira, Zhijian Chen, Satoshi Inoue, Jae U. Jung TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity Nature, 446, 7138, 916-920 Nature, 446, 7138, 916-920 Nature, 446, 7138, 916-920 2007/04 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Signaling pathways activated by microorganisms Signaling pathways activated by microorganisms Signaling pathways activated by microorganisms Current Opinion in Cell Biology, 19, 2, 185-191 Current Opinion in Cell Biology, 19, 2, 185-191 Current Opinion in Cell Biology, 19, 2, 185-191 2007/04 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira The Biology of Toll-Like Receptors in Mice The Biology of Toll-Like Receptors in Mice The Biology of Toll-Like Receptors in Mice The Mouse in Biomedical Research, 4, 109-117 The Mouse in Biomedical Research, 4, 109-117 The Mouse in Biomedical Research, 4, 109-117 2007 英語 公開
Cevayir Coban, Satoshi Uematsu, Nobuko Arisue, Shintaro Sato, Masahiro Yamamoto, Taro Kawai, Osamu Takeuchi, Hajime Hisaeda, Toshihiro Horii, Shizuo Akira Cevayir Coban, Satoshi Uematsu, Nobuko Arisue, Shintaro Sato, Masahiro Yamamoto, Taro Kawai, Osamu Takeuchi, Hajime Hisaeda, Toshihiro Horii, Shizuo Akira Cevayir Coban, Satoshi Uematsu, Nobuko Arisue, Shintaro Sato, Masahiro Yamamoto, Taro Kawai, Osamu Takeuchi, Hajime Hisaeda, Toshihiro Horii, Shizuo Akira Pathological role of Toll-like receptor signaling in cerebral malaria Pathological role of Toll-like receptor signaling in cerebral malaria Pathological role of Toll-like receptor signaling in cerebral malaria International Immunology, 19, 1, 67-79 International Immunology, 19, 1, 67-79 International Immunology, 19, 1, 67-79 2007/01 英語 研究論文(学術雑誌) 公開
Masahiro Yamamoto, Shintaro Sato, Tatsuya Saitoh, Hiroaki Sakurai, Satoshi Uematsu, Taro Kawai, Ken J. Ishii, Osamu Takeuchi, Shizuo Akira Masahiro Yamamoto, Shintaro Sato, Tatsuya Saitoh, Hiroaki Sakurai, Satoshi Uematsu, Taro Kawai, Ken J. Ishii, Osamu Takeuchi, Shizuo Akira Masahiro Yamamoto, Shintaro Sato, Tatsuya Saitoh, Hiroaki Sakurai, Satoshi Uematsu, Taro Kawai, Ken J. Ishii, Osamu Takeuchi, Shizuo Akira Cutting edge: Pivotal function of Ubc13 in thymocyte TCR signaling Cutting edge: Pivotal function of Ubc13 in thymocyte TCR signaling Cutting edge: Pivotal function of Ubc13 in thymocyte TCR signaling Journal of Immunology, 177, 11, 7520-7524 Journal of Immunology, 177, 11, 7520-7524 Journal of Immunology, 177, 11, 7520-7524 2006/12/01 英語 研究論文(学術雑誌) 公開
Rabindra N. Bhattacharjee, Kwon Sam Park, Yutaro Kumagai, Kazuhisa Okada, Masahiro Yamamoto, Satoshi Uematsu, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Tetsuya Iida, Takeshi Honda, Osamu Takeuchi, Shizuo Akira Rabindra N. Bhattacharjee, Kwon Sam Park, Yutaro Kumagai, Kazuhisa Okada, Masahiro Yamamoto, Satoshi Uematsu, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Tetsuya Iida, Takeshi Honda, Osamu Takeuchi, Shizuo Akira Rabindra N. Bhattacharjee, Kwon Sam Park, Yutaro Kumagai, Kazuhisa Okada, Masahiro Yamamoto, Satoshi Uematsu, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Tetsuya Iida, Takeshi Honda, Osamu Takeuchi, Shizuo Akira VP1686, a Vibrio type III secretion protein, induces Toll-like receptor-independent apoptosis in macrophage through NF-κB inhibition VP1686, a Vibrio type III secretion protein, induces Toll-like receptor-independent apoptosis in macrophage through NF-κB inhibition VP1686, a Vibrio type III secretion protein, induces Toll-like receptor-independent apoptosis in macrophage through NF-κB inhibition Journal of Biological Chemistry, 281, 48, 36897-36904 Journal of Biological Chemistry, 281, 48, 36897-36904 Journal of Biological Chemistry, 281, 48, 36897-36904 2006/12/01 英語 研究論文(学術雑誌) 公開
Kosuke Matsui, Yutaro Kumagai, Hiroki Kato, Shintaro Sato, Tatsukata Kawagoe, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira Kosuke Matsui, Yutaro Kumagai, Hiroki Kato, Shintaro Sato, Tatsukata Kawagoe, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira Kosuke Matsui, Yutaro Kumagai, Hiroki Kato, Shintaro Sato, Tatsukata Kawagoe, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira Cutting edge: Role of TANK-binding kinase 1 and inducible I kappa B kinase in IFN responses against viruses in innate inunune cells Cutting edge: Role of TANK-binding kinase 1 and inducible I kappa B kinase in IFN responses against viruses in innate inunune cells Cutting edge: Role of TANK-binding kinase 1 and inducible I kappa B kinase in IFN responses against viruses in innate inunune cells JOURNAL OF IMMUNOLOGY, 177, 9, 5785-5789 JOURNAL OF IMMUNOLOGY, 177, 9, 5785-5789 JOURNAL OF IMMUNOLOGY, 177, 9, 5785-5789 2006/11 英語 研究論文(学術雑誌) 公開
Kosuke Matsui, Yutaro Kumagai, Hiroki Kato, Shintaro Sato, Tatsukata Kawagoe, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira Kosuke Matsui, Yutaro Kumagai, Hiroki Kato, Shintaro Sato, Tatsukata Kawagoe, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira Kosuke Matsui, Yutaro Kumagai, Hiroki Kato, Shintaro Sato, Tatsukata Kawagoe, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira Cutting edge: Role of TANK-binding kinase 1 and inducible IκB kinase in IFN responses against viruses in innate immune cells Cutting edge: Role of TANK-binding kinase 1 and inducible IκB kinase in IFN responses against viruses in innate immune cells Cutting edge: Role of TANK-binding kinase 1 and inducible IκB kinase in IFN responses against viruses in innate immune cells Journal of Immunology, 177, 9, 5785-5789 Journal of Immunology, 177, 9, 5785-5789 Journal of Immunology, 177, 9, 5785-5789 2006/11/01 英語 研究論文(学術雑誌) 公開
Shintaro Sato, Hideki Sanjo, Tohru Tsujimura, Jun Ninomiya-Tsuji, Masahiro Yamamoto, Taro Kawai, Osamu Takeuchi, Shizuo Akira Shintaro Sato, Hideki Sanjo, Tohru Tsujimura, Jun Ninomiya-Tsuji, Masahiro Yamamoto, Taro Kawai, Osamu Takeuchi, Shizuo Akira Shintaro Sato, Hideki Sanjo, Tohru Tsujimura, Jun Ninomiya-Tsuji, Masahiro Yamamoto, Taro Kawai, Osamu Takeuchi, Shizuo Akira TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells International Immunology, 18, 10, 1405-1411 International Immunology, 18, 10, 1405-1411 International Immunology, 18, 10, 1405-1411 2006/10 英語 研究論文(学術雑誌) 公開
Masahiro Yamamoto, Toru Okamoto, Kiyoshi Takeda, Shintaro Sato, Hideki Sanjo, Satoshi Uematsu, Tatsuya Saitoh, Naoki Yamamoto, Hiroaki Sakurai, Ken J. Ishii, Shoji Yamaoka, Taro Kawai, Yoshiharu Matsuura, Osamu Takeuchi, Shizuo Akira Masahiro Yamamoto, Toru Okamoto, Kiyoshi Takeda, Shintaro Sato, Hideki Sanjo, Satoshi Uematsu, Tatsuya Saitoh, Naoki Yamamoto, Hiroaki Sakurai, Ken J. Ishii, Shoji Yamaoka, Taro Kawai, Yoshiharu Matsuura, Osamu Takeuchi, Shizuo Akira Masahiro Yamamoto, Toru Okamoto, Kiyoshi Takeda, Shintaro Sato, Hideki Sanjo, Satoshi Uematsu, Tatsuya Saitoh, Naoki Yamamoto, Hiroaki Sakurai, Ken J. Ishii, Shoji Yamaoka, Taro Kawai, Yoshiharu Matsuura, Osamu Takeuchi, Shizuo Akira Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling Nature Immunology, 7, 9, 962-970 Nature Immunology, 7, 9, 962-970 Nature Immunology, 7, 9, 962-970 2006/09 英語 研究論文(学術雑誌) 公開
Satoshi Uematsu, Myoung Ho Jang, Nicolas Chevrier, Zijin Guo, Yutaro Kumagai, Masahiro Yamamoto, Hiroki Kato, Nagako Sougawa, Hidenori Matsui, Hirotaka Kuwata, Hiroaki Hemmi, Cevayir Coban, Taro Kawai, Ken J. Ishii, Osamu Takeuchi, Masayuki Miyasaka, Kiyoshi Takeda, Shizuo Akira Satoshi Uematsu, Myoung Ho Jang, Nicolas Chevrier, Zijin Guo, Yutaro Kumagai, Masahiro Yamamoto, Hiroki Kato, Nagako Sougawa, Hidenori Matsui, Hirotaka Kuwata, Hiroaki Hemmi, Cevayir Coban, Taro Kawai, Ken J. Ishii, Osamu Takeuchi, Masayuki Miyasaka, Kiyoshi Takeda, Shizuo Akira Satoshi Uematsu, Myoung Ho Jang, Nicolas Chevrier, Zijin Guo, Yutaro Kumagai, Masahiro Yamamoto, Hiroki Kato, Nagako Sougawa, Hidenori Matsui, Hirotaka Kuwata, Hiroaki Hemmi, Cevayir Coban, Taro Kawai, Ken J. Ishii, Osamu Takeuchi, Masayuki Miyasaka, Kiyoshi Takeda, Shizuo Akira Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c<sup>+</sup> lamina propria cells Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c<sup>+</sup> lamina propria cells Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c<sup>+</sup> lamina propria cells Nature Immunology, 7, 8, 868-874 Nature Immunology, 7, 8, 868-874 Nature Immunology, 7, 8, 868-874 2006/08 英語 研究論文(学術雑誌) 公開
Himanshu Kumar, Taro Kawai, Hiroki Kato, Shintaro Sato, Ken Takahashi, Cevayir Coban, Masahiro Yamamoto, Satoshi Uematsu, Ken J. Ishii, Osamu Takeuchi, Shizuo Akira Himanshu Kumar, Taro Kawai, Hiroki Kato, Shintaro Sato, Ken Takahashi, Cevayir Coban, Masahiro Yamamoto, Satoshi Uematsu, Ken J. Ishii, Osamu Takeuchi, Shizuo Akira Himanshu Kumar, Taro Kawai, Hiroki Kato, Shintaro Sato, Ken Takahashi, Cevayir Coban, Masahiro Yamamoto, Satoshi Uematsu, Ken J. Ishii, Osamu Takeuchi, Shizuo Akira Essential role of IPS-1 in innate immune responses against RNA viruses Essential role of IPS-1 in innate immune responses against RNA viruses Essential role of IPS-1 in innate immune responses against RNA viruses Journal of Experimental Medicine, 203, 7, 1795-1803 Journal of Experimental Medicine, 203, 7, 1795-1803 Journal of Experimental Medicine, 203, 7, 1795-1803 2006/07/10 英語 研究論文(学術雑誌) 公開
Hiroki Kato, Osamu Takeuchi, Shizuo Akira Hiroki Kato, Osamu Takeuchi, Shizuo Akira Hiroki Kato, Osamu Takeuchi, Shizuo Akira Cell type specific involvement of RIG-I in antiviral responses Cell type specific involvement of RIG-I in antiviral responses Cell type specific involvement of RIG-I in antiviral responses Nippon rinsho. Japanese journal of clinical medicine, 64, 7, 1244-1247 Nippon rinsho. Japanese journal of clinical medicine, 64, 7, 1244-1247 Nippon rinsho. Japanese journal of clinical medicine, 64, 7, 1244-1247 2006/07 英語 公開
Hiroki Kato, Osamu Takeuchi, Shintaro Sato, Mitsutoshi Yoneyama, Masahiro Yamamoto, Kosuke Matsui, Satoshi Uematsu, Andreas Jung, Taro Kawai, Ken J. Ishii, Osamu Yamaguchi, Kinya Otsu, Tohru Tsujimura, Chang Sung Koh, Caetano Reis E Sousa, Yoshiharu Matsuura, Takashi Fujita, Shizuo Akira Hiroki Kato, Osamu Takeuchi, Shintaro Sato, Mitsutoshi Yoneyama, Masahiro Yamamoto, Kosuke Matsui, Satoshi Uematsu, Andreas Jung, Taro Kawai, Ken J. Ishii, Osamu Yamaguchi, Kinya Otsu, Tohru Tsujimura, Chang Sung Koh, Caetano Reis E Sousa, Yoshiharu Matsuura, Takashi Fujita, Shizuo Akira Hiroki Kato, Osamu Takeuchi, Shintaro Sato, Mitsutoshi Yoneyama, Masahiro Yamamoto, Kosuke Matsui, Satoshi Uematsu, Andreas Jung, Taro Kawai, Ken J. Ishii, Osamu Yamaguchi, Kinya Otsu, Tohru Tsujimura, Chang Sung Koh, Caetano Reis E Sousa, Yoshiharu Matsuura, Takashi Fujita, Shizuo Akira Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses Nature, 441, 1, 101-105 Nature, 441, 1, 101-105 Nature, 441, 1, 101-105 2006/05/04 英語 研究論文(学術雑誌) 公開
Ken J. Ishii, Cevayir Coban, Hiroki Kato, Ken Takahashi, Yuichi Torii, Fumihiko Takeshita, Holger Ludwig, Gerd Sutter, Koichi Suzuki, Hiroaki Hemmi, Shintaro Sato, Masahiro Yamamoto, Satoshi Uematsu, Taro Kawai, Osamu Takeuchi, Shizuo Akira Ken J. Ishii, Cevayir Coban, Hiroki Kato, Ken Takahashi, Yuichi Torii, Fumihiko Takeshita, Holger Ludwig, Gerd Sutter, Koichi Suzuki, Hiroaki Hemmi, Shintaro Sato, Masahiro Yamamoto, Satoshi Uematsu, Taro Kawai, Osamu Takeuchi, Shizuo Akira Ken J. Ishii, Cevayir Coban, Hiroki Kato, Ken Takahashi, Yuichi Torii, Fumihiko Takeshita, Holger Ludwig, Gerd Sutter, Koichi Suzuki, Hiroaki Hemmi, Shintaro Sato, Masahiro Yamamoto, Satoshi Uematsu, Taro Kawai, Osamu Takeuchi, Shizuo Akira Erratum: A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA (Nature Immunology (2005) vol. 7 (40-48)) Erratum: A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA (Nature Immunology (2005) vol. 7 (40-48)) Erratum: A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA (Nature Immunology (2005) vol. 7 (40-48)) Nature Immunology, 7, 4, 427-427 Nature Immunology, 7, 4, 427-427 Nature Immunology, 7, 4, 427-427 2006/04 英語 研究論文(学術雑誌) 公開
Nicolas Lapaque, Osamu Takeuchi, Fernando Corrales, Shizuo Akira, Ignacio Moriyon, Jonathan C. Howard, Jean Pierre Gorvel Nicolas Lapaque, Osamu Takeuchi, Fernando Corrales, Shizuo Akira, Ignacio Moriyon, Jonathan C. Howard, Jean Pierre Gorvel Nicolas Lapaque, Osamu Takeuchi, Fernando Corrales, Shizuo Akira, Ignacio Moriyon, Jonathan C. Howard, Jean Pierre Gorvel Differential inductions of TNF-α and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides Differential inductions of TNF-α and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides Differential inductions of TNF-α and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides Cellular Microbiology, 8, 3, 401-413 Cellular Microbiology, 8, 3, 401-413 Cellular Microbiology, 8, 3, 401-413 2006/03 英語 研究論文(学術雑誌) 公開
Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi Pathogen recognition and innate immunity Pathogen recognition and innate immunity Pathogen recognition and innate immunity Cell, 124, 4, 783-801 Cell, 124, 4, 783-801 Cell, 124, 4, 783-801 2006/02/24 英語 公開
Ken J. Ishii, Cevayir Coban, Hiroki Kato, Ken Takahashi, Yuichi Torii, Fumihiko Takeshita, Holger Ludwig, Gerd Sutter, Koichi Suzuki, Hiroaki Hemmi, Shintaro Sato, Masahiro Yamamoto, Satoshi Uematsu, Taro Kawai, Osamu Takeuchi, Shizuo Akira Ken J. Ishii, Cevayir Coban, Hiroki Kato, Ken Takahashi, Yuichi Torii, Fumihiko Takeshita, Holger Ludwig, Gerd Sutter, Koichi Suzuki, Hiroaki Hemmi, Shintaro Sato, Masahiro Yamamoto, Satoshi Uematsu, Taro Kawai, Osamu Takeuchi, Shizuo Akira Ken J. Ishii, Cevayir Coban, Hiroki Kato, Ken Takahashi, Yuichi Torii, Fumihiko Takeshita, Holger Ludwig, Gerd Sutter, Koichi Suzuki, Hiroaki Hemmi, Shintaro Sato, Masahiro Yamamoto, Satoshi Uematsu, Taro Kawai, Osamu Takeuchi, Shizuo Akira A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA Nature Immunology, 7, 1, 40-48 Nature Immunology, 7, 1, 40-48 Nature Immunology, 7, 1, 40-48 2006/01 英語 研究論文(学術雑誌) 公開
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Taro Kawai, Shintaro Sato, Ken J. Ishii, Cevayir Coban, Hiroaki Hemmi, Masahiro Yamamoto, Kenta Terai, Michiyuki Matsuda, Jun Ichiro Inoue, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira Taro Kawai, Shintaro Sato, Ken J. Ishii, Cevayir Coban, Hiroaki Hemmi, Masahiro Yamamoto, Kenta Terai, Michiyuki Matsuda, Jun Ichiro Inoue, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira Taro Kawai, Shintaro Sato, Ken J. Ishii, Cevayir Coban, Hiroaki Hemmi, Masahiro Yamamoto, Kenta Terai, Michiyuki Matsuda, Jun Ichiro Inoue, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 Nature Immunology, 5, 10, 1061-1068 Nature Immunology, 5, 10, 1061-1068 Nature Immunology, 5, 10, 1061-1068 2004/10 英語 研究論文(学術雑誌) 公開
T Shimizu, H Niizeki, O Takeuchi, Y Yamasaki, N Inamoto, Y Kusunoki, K Kobayashi, R Abe, H Shimizu, T Nishikawa, K Hashiguchi, J Nishihira T Shimizu, H Niizeki, O Takeuchi, Y Yamasaki, N Inamoto, Y Kusunoki, K Kobayashi, R Abe, H Shimizu, T Nishikawa, K Hashiguchi, J Nishihira T Shimizu, H Niizeki, O Takeuchi, Y Yamasaki, N Inamoto, Y Kusunoki, K Kobayashi, R Abe, H Shimizu, T Nishikawa, K Hashiguchi, J Nishihira Induction of macrophage migration inhibitory factor precedes the onset of acute tonsillitis Induction of macrophage migration inhibitory factor precedes the onset of acute tonsillitis Induction of macrophage migration inhibitory factor precedes the onset of acute tonsillitis MEDIATORS OF INFLAMMATION, 13, 4, 293-295 MEDIATORS OF INFLAMMATION, 13, 4, 293-295 MEDIATORS OF INFLAMMATION, 13, 4, 293-295 2004/08 英語 研究論文(学術雑誌) 公開
Masahiro Yamamoto, Soh Yamazaki, Satoshi Uematsu, Shintaro Sato, Hiroaki Hemmmi, Katsuaki Hoshino, Tsuneyasu Kaisho, Hirotaka Kuwata, Osamu Takeuchi, Koichiro Takeshige, Tatsuya Saitoh, Shoji Yamaoka, Naoki Yamamoto, Shunsuke Yamamoto, Tatsushi Muta, Kiyoshi Takeda, Shizuo Akira Masahiro Yamamoto, Soh Yamazaki, Satoshi Uematsu, Shintaro Sato, Hiroaki Hemmmi, Katsuaki Hoshino, Tsuneyasu Kaisho, Hirotaka Kuwata, Osamu Takeuchi, Koichiro Takeshige, Tatsuya Saitoh, Shoji Yamaoka, Naoki Yamamoto, Shunsuke Yamamoto, Tatsushi Muta, Kiyoshi Takeda, Shizuo Akira Masahiro Yamamoto, Soh Yamazaki, Satoshi Uematsu, Shintaro Sato, Hiroaki Hemmmi, Katsuaki Hoshino, Tsuneyasu Kaisho, Hirotaka Kuwata, Osamu Takeuchi, Koichiro Takeshige, Tatsuya Saitoh, Shoji Yamaoka, Naoki Yamamoto, Shunsuke Yamamoto, Tatsushi Muta, Kiyoshi Takeda, Shizuo Akira Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ Nature, 430, 6996, 218-222 Nature, 430, 6996, 218-222 Nature, 430, 6996, 218-222 2004/07/08 英語 研究論文(学術雑誌) 公開
Hiroaki Hemmi, Osamu Takeuchi, Shintaro Sato, Masahiro Yamamoto, Tsuneyasu Kaisho, Hideki Sanjo, Taro Kawai, Katsuaki Hoshino, Kiyoshi Takeda, Shizuo Akira Hiroaki Hemmi, Osamu Takeuchi, Shintaro Sato, Masahiro Yamamoto, Tsuneyasu Kaisho, Hideki Sanjo, Taro Kawai, Katsuaki Hoshino, Kiyoshi Takeda, Shizuo Akira Hiroaki Hemmi, Osamu Takeuchi, Shintaro Sato, Masahiro Yamamoto, Tsuneyasu Kaisho, Hideki Sanjo, Taro Kawai, Katsuaki Hoshino, Kiyoshi Takeda, Shizuo Akira The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection Journal of Experimental Medicine, 199, 12, 1641-1650 Journal of Experimental Medicine, 199, 12, 1641-1650 Journal of Experimental Medicine, 199, 12, 1641-1650 2004/06/21 英語 研究論文(学術雑誌) 公開
Masato Okamoto, Oh E. Go, Tetsuya Oshikawa, Sachiko Furuichi, Tomoyuki Tano, Sharif U. Ahmed, Sachiko Akashi, Kensuke Miyake, Osamu Takeuchi, Shizuo Akira, Kunisuke Himeno, Mitsunobu Sato, Shinya Ohkubo Masato Okamoto, Oh E. Go, Tetsuya Oshikawa, Sachiko Furuichi, Tomoyuki Tano, Sharif U. Ahmed, Sachiko Akashi, Kensuke Miyake, Osamu Takeuchi, Shizuo Akira, Kunisuke Himeno, Mitsunobu Sato, Shinya Ohkubo Masato Okamoto, Oh E. Go, Tetsuya Oshikawa, Sachiko Furuichi, Tomoyuki Tano, Sharif U. Ahmed, Sachiko Akashi, Kensuke Miyake, Osamu Takeuchi, Shizuo Akira, Kunisuke Himeno, Mitsunobu Sato, Shinya Ohkubo Toll-like receptor 4 mediates the antitumor host response induced by a 55-Kilodalton protein isolated from Aeginetia indica L., a parasitic plant Toll-like receptor 4 mediates the antitumor host response induced by a 55-Kilodalton protein isolated from Aeginetia indica L., a parasitic plant Toll-like receptor 4 mediates the antitumor host response induced by a 55-Kilodalton protein isolated from Aeginetia indica L., a parasitic plant Clinical and Diagnostic Laboratory Immunology, 11, 3, 483-495 Clinical and Diagnostic Laboratory Immunology, 11, 3, 483-495 Clinical and Diagnostic Laboratory Immunology, 11, 3, 483-495 2004/05 英語 研究論文(学術雑誌) 公開
Amélie Honstettre, Eric Ghigo, Alix Moynault, Christian Capo, Rudolf Toman, Shizuo Akira, Osamu Takeuchi, Hubert Lepidi, Didier Raoult, Jean Louis Mege Amélie Honstettre, Eric Ghigo, Alix Moynault, Christian Capo, Rudolf Toman, Shizuo Akira, Osamu Takeuchi, Hubert Lepidi, Didier Raoult, Jean Louis Mege Amélie Honstettre, Eric Ghigo, Alix Moynault, Christian Capo, Rudolf Toman, Shizuo Akira, Osamu Takeuchi, Hubert Lepidi, Didier Raoult, Jean Louis Mege Lipopolysaccharide from Coxiella burnetii Is Involved in Bacterial Phagocytosis, Filamentous Actin Reorganization, and Inflammatory Responses through Toll-Like Receptor 4 Lipopolysaccharide from Coxiella burnetii Is Involved in Bacterial Phagocytosis, Filamentous Actin Reorganization, and Inflammatory Responses through Toll-Like Receptor 4 Lipopolysaccharide from Coxiella burnetii Is Involved in Bacterial Phagocytosis, Filamentous Actin Reorganization, and Inflammatory Responses through Toll-Like Receptor 4 Journal of Immunology, 172, 6, 3695-3703 Journal of Immunology, 172, 6, 3695-3703 Journal of Immunology, 172, 6, 3695-3703 2004/03/15 英語 研究論文(学術雑誌) 公開
Sylvia Knapp, Catharina W. Wieland, Cornelis Van't Veer, Osamu Takeuchi, Shizuo Akira, Sandrine Florquin, Tom Van Der Poll Sylvia Knapp, Catharina W. Wieland, Cornelis Van't Veer, Osamu Takeuchi, Shizuo Akira, Sandrine Florquin, Tom Van Der Poll Sylvia Knapp, Catharina W. Wieland, Cornelis Van't Veer, Osamu Takeuchi, Shizuo Akira, Sandrine Florquin, Tom Van Der Poll Toll-Like Receptor 2 Plays a Role in the Early Inflammatory Response to Murine Pneumococcal Pneumonia but Does Not Contribute to Antibacterial Defense Toll-Like Receptor 2 Plays a Role in the Early Inflammatory Response to Murine Pneumococcal Pneumonia but Does Not Contribute to Antibacterial Defense Toll-Like Receptor 2 Plays a Role in the Early Inflammatory Response to Murine Pneumococcal Pneumonia but Does Not Contribute to Antibacterial Defense Journal of Immunology, 172, 5, 3132-3138 Journal of Immunology, 172, 5, 3132-3138 Journal of Immunology, 172, 5, 3132-3138 2004/03/01 英語 研究論文(学術雑誌) 公開
Akiko Shiratsuchi, Ikuko Watanabe, Osamu Takeuchi, Shizuo Akira, Yoshinobu Nakanishi Akiko Shiratsuchi, Ikuko Watanabe, Osamu Takeuchi, Shizuo Akira, Yoshinobu Nakanishi Akiko Shiratsuchi, Ikuko Watanabe, Osamu Takeuchi, Shizuo Akira, Yoshinobu Nakanishi Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages Journal of Immunology, 172, 4, 2039-2047 Journal of Immunology, 172, 4, 2039-2047 Journal of Immunology, 172, 4, 2039-2047 2004/02/15 英語 研究論文(学術雑誌) 公開
M. Salomé Gomes, Manuela Flórido, João V. Cordeiro, C. Miguel Teixeira, Osamu Takeuchi, Shizuo Akira, Rui Appelberg M. Salomé Gomes, Manuela Flórido, João V. Cordeiro, C. Miguel Teixeira, Osamu Takeuchi, Shizuo Akira, Rui Appelberg M. Salomé Gomes, Manuela Flórido, João V. Cordeiro, C. Miguel Teixeira, Osamu Takeuchi, Shizuo Akira, Rui Appelberg Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium Immunology, 111, 2, 179-185 Immunology, 111, 2, 179-185 Immunology, 111, 2, 179-185 2004/02 英語 研究論文(学術雑誌) 公開
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Osamu Takeuchi, Hiroaki Hemmi, Shizuo Akira Osamu Takeuchi, Hiroaki Hemmi, Shizuo Akira Osamu Takeuchi, Hiroaki Hemmi, Shizuo Akira Interferon response by Toll-like receptor signaling Interferon response by Toll-like receptor signaling Interferon response by Toll-like receptor signaling Journal of Endotoxin Research, 10, 4, 252-256 Journal of Endotoxin Research, 10, 4, 252-256 Journal of Endotoxin Research, 10, 4, 252-256 2004 英語 研究論文(学術雑誌) 公開
Tetsuro Shishido, Naoki Nozaki, Seiji Yamaguchi, Yoko Shibata, Joji Nitobe, Takuya Miyamoto, Hiroki Takahashi, Takanori Arimoto, Kunihiko Maeda, Mitsunori Yamakawa, Osamu Takeuchi, Shizuo Akira, Yasuchika Takeishi, Isao Kubota Tetsuro Shishido, Naoki Nozaki, Seiji Yamaguchi, Yoko Shibata, Joji Nitobe, Takuya Miyamoto, Hiroki Takahashi, Takanori Arimoto, Kunihiko Maeda, Mitsunori Yamakawa, Osamu Takeuchi, Shizuo Akira, Yasuchika Takeishi, Isao Kubota Tetsuro Shishido, Naoki Nozaki, Seiji Yamaguchi, Yoko Shibata, Joji Nitobe, Takuya Miyamoto, Hiroki Takahashi, Takanori Arimoto, Kunihiko Maeda, Mitsunori Yamakawa, Osamu Takeuchi, Shizuo Akira, Yasuchika Takeishi, Isao Kubota Toll-Like Receptor-2 Modulates Ventricular Remodeling after Myocardial Infarction Toll-Like Receptor-2 Modulates Ventricular Remodeling after Myocardial Infarction Toll-Like Receptor-2 Modulates Ventricular Remodeling after Myocardial Infarction Circulation, 108, 23, 2905-2910 Circulation, 108, 23, 2905-2910 Circulation, 108, 23, 2905-2910 2003/12/09 英語 研究論文(学術雑誌) 公開
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Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi, Satoshi Uematsu, Katsuaki Hoshino, Tsuneyasu Kaisho, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi, Satoshi Uematsu, Katsuaki Hoshino, Tsuneyasu Kaisho, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi, Satoshi Uematsu, Katsuaki Hoshino, Tsuneyasu Kaisho, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway Nature Immunology, 4, 11, 1144-1150 Nature Immunology, 4, 11, 1144-1150 Nature Immunology, 4, 11, 1144-1150 2003/11 英語 研究論文(学術雑誌) 公開
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Masato Okamoto, Tetsuya Oshikawa, Tomuyuki Tano, Go Ohe, Sachiko Furuichi, Hidetomo Nishikawa, Sharif Uddin Ahmed, Sachiko Akashi, Kensuke Miyake, Osamu Takeuchi, Shizuo Akira, Yoichiro Moriya, Shuzo Marsubara, Yoshiki Ryoma, Motoo Saito, Mitsunobu Sato Masato Okamoto, Tetsuya Oshikawa, Tomuyuki Tano, Go Ohe, Sachiko Furuichi, Hidetomo Nishikawa, Sharif Uddin Ahmed, Sachiko Akashi, Kensuke Miyake, Osamu Takeuchi, Shizuo Akira, Yoichiro Moriya, Shuzo Marsubara, Yoshiki Ryoma, Motoo Saito, Mitsunobu Sato Masato Okamoto, Tetsuya Oshikawa, Tomuyuki Tano, Go Ohe, Sachiko Furuichi, Hidetomo Nishikawa, Sharif Uddin Ahmed, Sachiko Akashi, Kensuke Miyake, Osamu Takeuchi, Shizuo Akira, Yoichiro Moriya, Shuzo Marsubara, Yoshiki Ryoma, Motoo Saito, Mitsunobu Sato Involvement of Toll-like receptor 4 signaling in interferon-γ production and antitumor effect by streptococcal agent OK-432 Involvement of Toll-like receptor 4 signaling in interferon-γ production and antitumor effect by streptococcal agent OK-432 Involvement of Toll-like receptor 4 signaling in interferon-γ production and antitumor effect by streptococcal agent OK-432 Journal of the National Cancer Institute, 95, 4, 316-326 Journal of the National Cancer Institute, 95, 4, 316-326 Journal of the National Cancer Institute, 95, 4, 316-326 2003/02/19 英語 研究論文(学術雑誌) 公開
M Okamoto, T Oshikawa, T Tano, G Ohe, S Furuichi, H Nishikawa, SU Ahmed, S Akashi, K Miyake, O Takeuchi, S Akira, Y Moriya, S Matsubara, Y Ryoma, M Saito, M Sato M Okamoto, T Oshikawa, T Tano, G Ohe, S Furuichi, H Nishikawa, SU Ahmed, S Akashi, K Miyake, O Takeuchi, S Akira, Y Moriya, S Matsubara, Y Ryoma, M Saito, M Sato M Okamoto, T Oshikawa, T Tano, G Ohe, S Furuichi, H Nishikawa, SU Ahmed, S Akashi, K Miyake, O Takeuchi, S Akira, Y Moriya, S Matsubara, Y Ryoma, M Saito, M Sato Involvement of toll-like receptor 4 signaling in interferon-gamma production and antitumor effect by streptococcal agent OK-432 Involvement of toll-like receptor 4 signaling in interferon-gamma production and antitumor effect by streptococcal agent OK-432 Involvement of toll-like receptor 4 signaling in interferon-gamma production and antitumor effect by streptococcal agent OK-432 JOURNAL OF THE NATIONAL CANCER INSTITUTE, 95, 4, 316-326 JOURNAL OF THE NATIONAL CANCER INSTITUTE, 95, 4, 316-326 JOURNAL OF THE NATIONAL CANCER INSTITUTE, 95, 4, 316-326 2003/02 英語 研究論文(学術雑誌) 公開
Isamu Sugawara, Hiroyuki Yamada, Chuanyou Li, Satoru Mizuno, Osamu Takeuchi, Shizuo Akira Isamu Sugawara, Hiroyuki Yamada, Chuanyou Li, Satoru Mizuno, Osamu Takeuchi, Shizuo Akira Isamu Sugawara, Hiroyuki Yamada, Chuanyou Li, Satoru Mizuno, Osamu Takeuchi, Shizuo Akira Mycobacterial infection in TLR2 and TLR6 knockout mice Mycobacterial infection in TLR2 and TLR6 knockout mice Mycobacterial infection in TLR2 and TLR6 knockout mice Microbiology and Immunology, 47, 5, 327-336 Microbiology and Immunology, 47, 5, 327-336 Microbiology and Immunology, 47, 5, 327-336 2003 英語 研究論文(学術雑誌) 公開
Riyoko Tamai, Shunji Sugawara, Osamu Takeuchi, Shizuo Akira, Haruhiko Takada Riyoko Tamai, Shunji Sugawara, Osamu Takeuchi, Shizuo Akira, Haruhiko Takada Riyoko Tamai, Shunji Sugawara, Osamu Takeuchi, Shizuo Akira, Haruhiko Takada Synergistic effects of lipopolysaccharide and interferon-γ in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14, toll-like receptor 4, MD-2 and MyD88 expression Synergistic effects of lipopolysaccharide and interferon-γ in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14, toll-like receptor 4, MD-2 and MyD88 expression Synergistic effects of lipopolysaccharide and interferon-γ in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14, toll-like receptor 4, MD-2 and MyD88 expression Journal of Endotoxin Research, 9, 3, 145-153 Journal of Endotoxin Research, 9, 3, 145-153 Journal of Endotoxin Research, 9, 3, 145-153 2003 英語 研究論文(学術雑誌) 公開
Masahiro Yamamoto, Shintaro Sato, Kiyotoshi Mori, Katsuaki Hoshino, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira Masahiro Yamamoto, Shintaro Sato, Kiyotoshi Mori, Katsuaki Hoshino, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira Masahiro Yamamoto, Shintaro Sato, Kiyotoshi Mori, Katsuaki Hoshino, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling Journal of Immunology, 169, 12, 6668-6672 Journal of Immunology, 169, 12, 6668-6672 Journal of Immunology, 169, 12, 6668-6672 2002/12/15 英語 研究論文(学術雑誌) 公開
M Yamamoto, S Sato, K Mori, K Hoshino, O Takeuchi, K Takeda, S Akira M Yamamoto, S Sato, K Mori, K Hoshino, O Takeuchi, K Takeda, S Akira M Yamamoto, S Sato, K Mori, K Hoshino, O Takeuchi, K Takeda, S Akira Cutting edge: A novel toll/IL-1 receptor Domain containing adapter that preferentially activates the IFN-beta promoter in the toll-like receptor signaling Cutting edge: A novel toll/IL-1 receptor Domain containing adapter that preferentially activates the IFN-beta promoter in the toll-like receptor signaling Cutting edge: A novel toll/IL-1 receptor Domain containing adapter that preferentially activates the IFN-beta promoter in the toll-like receptor signaling JOURNAL OF IMMUNOLOGY, 169, 12, 6668-6672 JOURNAL OF IMMUNOLOGY, 169, 12, 6668-6672 JOURNAL OF IMMUNOLOGY, 169, 12, 6668-6672 2002/12 英語 研究論文(学術雑誌) 公開
Michael Morr, Osamu Takeuchi, Shizuo Akira, Markus M. Simon, Peter F. Mühlradt Michael Morr, Osamu Takeuchi, Shizuo Akira, Markus M. Simon, Peter F. Mühlradt Michael Morr, Osamu Takeuchi, Shizuo Akira, Markus M. Simon, Peter F. Mühlradt Differential recognition of structural details of bacterial lipopeptides by toll-like receptors Differential recognition of structural details of bacterial lipopeptides by toll-like receptors Differential recognition of structural details of bacterial lipopeptides by toll-like receptors European Journal of Immunology, 32, 12, 3337-3347 European Journal of Immunology, 32, 12, 3337-3347 European Journal of Immunology, 32, 12, 3337-3347 2002/12/01 英語 研究論文(学術雑誌) 公開
Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi, Hideki Sanjo, Satoshi Uematsu, Tsuneyasu Kaisho, Katsuaki Hoshino, Osamu Takeuchi, Masaya Kobayashi, Takashi Fujita, Kiyoshi Takeda, Shizuo Akira Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi, Hideki Sanjo, Satoshi Uematsu, Tsuneyasu Kaisho, Katsuaki Hoshino, Osamu Takeuchi, Masaya Kobayashi, Takashi Fujita, Kiyoshi Takeda, Shizuo Akira Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi, Hideki Sanjo, Satoshi Uematsu, Tsuneyasu Kaisho, Katsuaki Hoshino, Osamu Takeuchi, Masaya Kobayashi, Takashi Fujita, Kiyoshi Takeda, Shizuo Akira Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 Nature, 420, 6913, 324-329 Nature, 420, 6913, 324-329 Nature, 420, 6913, 324-329 2002/11/21 英語 研究論文(学術雑誌) 公開
Reiko Nakagawa, Tetsuji Naka, Hiroko Tsutsui, Minoru Fujimoto, Akihiro Kimura, Tatsuo Abe, Ekihiro Seki, Shintaro Sato, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira, Koichi Yamanishi, Ichirou Kawase, Kenji Nakanishi, Tadamitsu Kishimoto Reiko Nakagawa, Tetsuji Naka, Hiroko Tsutsui, Minoru Fujimoto, Akihiro Kimura, Tatsuo Abe, Ekihiro Seki, Shintaro Sato, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira, Koichi Yamanishi, Ichirou Kawase, Kenji Nakanishi, Tadamitsu Kishimoto Reiko Nakagawa, Tetsuji Naka, Hiroko Tsutsui, Minoru Fujimoto, Akihiro Kimura, Tatsuo Abe, Ekihiro Seki, Shintaro Sato, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira, Koichi Yamanishi, Ichirou Kawase, Kenji Nakanishi, Tadamitsu Kishimoto SOCS-1 participates in negative regulation of LPS responses SOCS-1 participates in negative regulation of LPS responses SOCS-1 participates in negative regulation of LPS responses Immunity, 17, 5, 677-687 Immunity, 17, 5, 677-687 Immunity, 17, 5, 677-687 2002/11/01 英語 研究論文(学術雑誌) 公開
Tomohiko Ogawa, Yasuyuki Asai, Masahito Hashimoto, Osamu Takeuchi, Tomoko Kurita, Yasunobu Yoshikai, Kensuke Miyake, Shizuo Akira Tomohiko Ogawa, Yasuyuki Asai, Masahito Hashimoto, Osamu Takeuchi, Tomoko Kurita, Yasunobu Yoshikai, Kensuke Miyake, Shizuo Akira Tomohiko Ogawa, Yasuyuki Asai, Masahito Hashimoto, Osamu Takeuchi, Tomoko Kurita, Yasunobu Yoshikai, Kensuke Miyake, Shizuo Akira Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88- dependent signaling pathway Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88- dependent signaling pathway Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88- dependent signaling pathway International Immunology, 14, 11, 1325-1332 International Immunology, 14, 11, 1325-1332 International Immunology, 14, 11, 1325-1332 2002/11/01 英語 研究論文(学術雑誌) 公開
Philipp Henneke, Osamu Takeuchi, Richard Malley, Egil Lien, Robin R. Ingalls, Mason W. Freeman, Tanya Mayadas, Victor Nizet, Shizuo Akira, Dennis L. Kasper, Douglas T. Golenbock Philipp Henneke, Osamu Takeuchi, Richard Malley, Egil Lien, Robin R. Ingalls, Mason W. Freeman, Tanya Mayadas, Victor Nizet, Shizuo Akira, Dennis L. Kasper, Douglas T. Golenbock Philipp Henneke, Osamu Takeuchi, Richard Malley, Egil Lien, Robin R. Ingalls, Mason W. Freeman, Tanya Mayadas, Victor Nizet, Shizuo Akira, Dennis L. Kasper, Douglas T. Golenbock Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways Journal of Immunology, 169, 7, 3970-3977 Journal of Immunology, 169, 7, 3970-3977 Journal of Immunology, 169, 7, 3970-3977 2002/10/01 英語 研究論文(学術雑誌) 公開
Ekihiro Seki, Hiroko Tsutsui, Noriko M. Tsuji, Nobuki Hayashi, Keishi Adachi, Hiroki Nakano, Shizue Futatsugi-Yumikura, Osamu Takeuchi, Katsuaki Hoshino, Shizuo Akira, Jiro Fujimoto, Kenji Nakanishi Ekihiro Seki, Hiroko Tsutsui, Noriko M. Tsuji, Nobuki Hayashi, Keishi Adachi, Hiroki Nakano, Shizue Futatsugi-Yumikura, Osamu Takeuchi, Katsuaki Hoshino, Shizuo Akira, Jiro Fujimoto, Kenji Nakanishi Ekihiro Seki, Hiroko Tsutsui, Noriko M. Tsuji, Nobuki Hayashi, Keishi Adachi, Hiroki Nakano, Shizue Futatsugi-Yumikura, Osamu Takeuchi, Katsuaki Hoshino, Shizuo Akira, Jiro Fujimoto, Kenji Nakanishi Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice Journal of Immunology, 169, 7, 3863-3868 Journal of Immunology, 169, 7, 3863-3868 Journal of Immunology, 169, 7, 3863-3868 2002/10/01 英語 研究論文(学術雑誌) 公開
Fumie Aosai, Mei Chen, Hyun Kyu Kang, Hye Seong Mun, Kazumi Norose, Lian Xun Piao, Masashi Kobayashi, Osamu Takeuchi, Shizuo Akira, Akihiko Yano Fumie Aosai, Mei Chen, Hyun Kyu Kang, Hye Seong Mun, Kazumi Norose, Lian Xun Piao, Masashi Kobayashi, Osamu Takeuchi, Shizuo Akira, Akihiko Yano Fumie Aosai, Mei Chen, Hyun Kyu Kang, Hye Seong Mun, Kazumi Norose, Lian Xun Piao, Masashi Kobayashi, Osamu Takeuchi, Shizuo Akira, Akihiko Yano Toxoplasma gondii-derived heat shock protein HSP70 functions as a B cell mitogen Toxoplasma gondii-derived heat shock protein HSP70 functions as a B cell mitogen Toxoplasma gondii-derived heat shock protein HSP70 functions as a B cell mitogen Cell Stress and Chaperones, 7, 4, 357-364 Cell Stress and Chaperones, 7, 4, 357-364 Cell Stress and Chaperones, 7, 4, 357-364 2002/10 英語 研究論文(学術雑誌) 公開
M. Chen, F. Aosai, K. Norose, H. S. Mun, O. Takeuchi, S. Akira, A. Yano M. Chen, F. Aosai, K. Norose, H. S. Mun, O. Takeuchi, S. Akira, A. Yano M. Chen, F. Aosai, K. Norose, H. S. Mun, O. Takeuchi, S. Akira, A. Yano Involvement of MyD88 in host defense and the down-regulation of anti-heat shock protein 70 autoantibody formation by MyD88 in Toxoplasma gondii-infected mice Involvement of MyD88 in host defense and the down-regulation of anti-heat shock protein 70 autoantibody formation by MyD88 in Toxoplasma gondii-infected mice Involvement of MyD88 in host defense and the down-regulation of anti-heat shock protein 70 autoantibody formation by MyD88 in Toxoplasma gondii-infected mice Journal of Parasitology, 88, 5, 1017-1019 Journal of Parasitology, 88, 5, 1017-1019 Journal of Parasitology, 88, 5, 1017-1019 2002/10 英語 研究論文(学術雑誌) 公開
K Hoshino, T Kaisho, T Iwabe, O Takeuchi, S Akira K Hoshino, T Kaisho, T Iwabe, O Takeuchi, S Akira K Hoshino, T Kaisho, T Iwabe, O Takeuchi, S Akira Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation INTERNATIONAL IMMUNOLOGY, 14, 10, 1225-1231 INTERNATIONAL IMMUNOLOGY, 14, 10, 1225-1231 INTERNATIONAL IMMUNOLOGY, 14, 10, 1225-1231 2002/10 英語 研究論文(学術雑誌) 公開
Hideyuki Shimizu, Tetsuya Matsuguchi, Yoshihide Fukuda, Isao Nakano, Tetsuo Hayakawa, Osamu Takeuchi, Shizuo Akira, Masayuki Umemura, Takashi Suda, Yasunobu Yoshikai Hideyuki Shimizu, Tetsuya Matsuguchi, Yoshihide Fukuda, Isao Nakano, Tetsuo Hayakawa, Osamu Takeuchi, Shizuo Akira, Masayuki Umemura, Takashi Suda, Yasunobu Yoshikai Hideyuki Shimizu, Tetsuya Matsuguchi, Yoshihide Fukuda, Isao Nakano, Tetsuo Hayakawa, Osamu Takeuchi, Shizuo Akira, Masayuki Umemura, Takashi Suda, Yasunobu Yoshikai Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice Gastroenterology, 123, 4, 1265-1277 Gastroenterology, 123, 4, 1265-1277 Gastroenterology, 123, 4, 1265-1277 2002/10 英語 研究論文(学術雑誌) 公開
T Yamao, T Noguchi, O Takeuchi, U Nishiyama, H Morita, T Hagiwara, H Akahori, T Kato, K Inagaki, H Okazawa, Y Hayashi, T Matozaki, K Takeda, S Akira, M Kasuga T Yamao, T Noguchi, O Takeuchi, U Nishiyama, H Morita, T Hagiwara, H Akahori, T Kato, K Inagaki, H Okazawa, Y Hayashi, T Matozaki, K Takeda, S Akira, M Kasuga T Yamao, T Noguchi, O Takeuchi, U Nishiyama, H Morita, T Hagiwara, H Akahori, T Kato, K Inagaki, H Okazawa, Y Hayashi, T Matozaki, K Takeda, S Akira, M Kasuga Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1 Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1 Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 42, 39833-39839 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 42, 39833-39839 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 42, 39833-39839 2002/10 英語 研究論文(学術雑誌) 公開
Katsuaki Hoshino, Tsuneyasu Kaisho, Tomio Iwabe, Osamu Takeuchi, Shizuo Akira Katsuaki Hoshino, Tsuneyasu Kaisho, Tomio Iwabe, Osamu Takeuchi, Shizuo Akira Katsuaki Hoshino, Tsuneyasu Kaisho, Tomio Iwabe, Osamu Takeuchi, Shizuo Akira Differential involvement of IFN-β in toll-like receptor-stimulated dendritic cell activation Differential involvement of IFN-β in toll-like receptor-stimulated dendritic cell activation Differential involvement of IFN-β in toll-like receptor-stimulated dendritic cell activation International Immunology, 14, 10, 1225-1231 International Immunology, 14, 10, 1225-1231 International Immunology, 14, 10, 1225-1231 2002/10/01 英語 研究論文(学術雑誌) 公開
Trude H. Flo, Liv Ryan, Eicke Latz, Osamu Takeuchi, Brian G. Monks, Egil Lien, Oyvind Halaas, Shizuo Akira, Gudmund Skjåk-Bræk, Douglas T. Golenbock, Terje Espevik Trude H. Flo, Liv Ryan, Eicke Latz, Osamu Takeuchi, Brian G. Monks, Egil Lien, Oyvind Halaas, Shizuo Akira, Gudmund Skjåk-Bræk, Douglas T. Golenbock, Terje Espevik Trude H. Flo, Liv Ryan, Eicke Latz, Osamu Takeuchi, Brian G. Monks, Egil Lien, Oyvind Halaas, Shizuo Akira, Gudmund Skjåk-Bræk, Douglas T. Golenbock, Terje Espevik Involvement of Toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers Involvement of Toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers Involvement of Toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers Journal of Biological Chemistry, 277, 38, 35489-35495 Journal of Biological Chemistry, 277, 38, 35489-35495 Journal of Biological Chemistry, 277, 38, 35489-35495 2002/09/20 英語 研究論文(学術雑誌) 公開
Naotake Tsuboi, Yasunobu Yoshikai, Seiichi Matsuo, Takeshi Kikuchi, Ken Ichiro Iwami, Yoshiyuki Nagai, Osamu Takeuchi, Shizuo Akira, Tetsuya Matsuguchi Naotake Tsuboi, Yasunobu Yoshikai, Seiichi Matsuo, Takeshi Kikuchi, Ken Ichiro Iwami, Yoshiyuki Nagai, Osamu Takeuchi, Shizuo Akira, Tetsuya Matsuguchi Naotake Tsuboi, Yasunobu Yoshikai, Seiichi Matsuo, Takeshi Kikuchi, Ken Ichiro Iwami, Yoshiyuki Nagai, Osamu Takeuchi, Shizuo Akira, Tetsuya Matsuguchi Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells Journal of Immunology, 169, 4, 2026-2033 Journal of Immunology, 169, 4, 2026-2033 Journal of Immunology, 169, 4, 2026-2033 2002/08/15 英語 研究論文(学術雑誌) 公開
Jenny Kim, Maria Teresa Ochoa, Stephan R. Krutzik, Osamu Takeuchi, Satoshi Uematsu, Annaliza J. Legaspi, Hans D. Brightbill, Diana Holland, William J. Cunliffe, Shizuo Akira, Peter A. Sieling, Paul J. Godowski, Robert L. Modlin Jenny Kim, Maria Teresa Ochoa, Stephan R. Krutzik, Osamu Takeuchi, Satoshi Uematsu, Annaliza J. Legaspi, Hans D. Brightbill, Diana Holland, William J. Cunliffe, Shizuo Akira, Peter A. Sieling, Paul J. Godowski, Robert L. Modlin Jenny Kim, Maria Teresa Ochoa, Stephan R. Krutzik, Osamu Takeuchi, Satoshi Uematsu, Annaliza J. Legaspi, Hans D. Brightbill, Diana Holland, William J. Cunliffe, Shizuo Akira, Peter A. Sieling, Paul J. Godowski, Robert L. Modlin Activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses Activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses Activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses Journal of Immunology, 169, 3, 1535-1541 Journal of Immunology, 169, 3, 1535-1541 Journal of Immunology, 169, 3, 1535-1541 2002/08/01 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi, Shintaro Sato, Takao Horiuchi, Katsuaki Hoshino, Kiyoshi Takeda, Zhongyun Dong, Robert L. Modlin, Shizuo Akira Osamu Takeuchi, Shintaro Sato, Takao Horiuchi, Katsuaki Hoshino, Kiyoshi Takeda, Zhongyun Dong, Robert L. Modlin, Shizuo Akira Osamu Takeuchi, Shintaro Sato, Takao Horiuchi, Katsuaki Hoshino, Kiyoshi Takeda, Zhongyun Dong, Robert L. Modlin, Shizuo Akira Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins Journal of Immunology, 169, 1, 10-14 Journal of Immunology, 169, 1, 10-14 Journal of Immunology, 169, 1, 10-14 2002/07/01 英語 研究論文(学術雑誌) 公開
T Kaisho, K Hoshino, T Iwabe, O Takeuchi, T Yasui, S Akira T Kaisho, K Hoshino, T Iwabe, O Takeuchi, T Yasui, S Akira T Kaisho, K Hoshino, T Iwabe, O Takeuchi, T Yasui, S Akira Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation INTERNATIONAL IMMUNOLOGY, 14, 7, 695-700 INTERNATIONAL IMMUNOLOGY, 14, 7, 695-700 INTERNATIONAL IMMUNOLOGY, 14, 7, 695-700 2002/07 英語 研究論文(学術雑誌) 公開
PS Coelho, A Klein, A Talvani, SF Coutinho, O Takeuchi, S Akira, JS Silva, H Canizzaro, RT Gazzinelli, MM Teixeira PS Coelho, A Klein, A Talvani, SF Coutinho, O Takeuchi, S Akira, JS Silva, H Canizzaro, RT Gazzinelli, MM Teixeira PS Coelho, A Klein, A Talvani, SF Coutinho, O Takeuchi, S Akira, JS Silva, H Canizzaro, RT Gazzinelli, MM Teixeira Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophages Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophages Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophages JOURNAL OF LEUKOCYTE BIOLOGY, 71, 5, 837-844 JOURNAL OF LEUKOCYTE BIOLOGY, 71, 5, 837-844 JOURNAL OF LEUKOCYTE BIOLOGY, 71, 5, 837-844 2002/05 英語 研究論文(学術雑誌) 公開
Patrícia S. Coelho, André Klein, André Talvani, Sibele F. Coutinho, Osamu Takeuchi, Shizuo Akira, João S. Silva, Hélia Canizzaro, Ricardo T. Gazzinelli, Mauro M. Teixeira Patrícia S. Coelho, André Klein, André Talvani, Sibele F. Coutinho, Osamu Takeuchi, Shizuo Akira, João S. Silva, Hélia Canizzaro, Ricardo T. Gazzinelli, Mauro M. Teixeira Patrícia S. Coelho, André Klein, André Talvani, Sibele F. Coutinho, Osamu Takeuchi, Shizuo Akira, João S. Silva, Hélia Canizzaro, Ricardo T. Gazzinelli, Mauro M. Teixeira Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from trypanosoma cruzi Trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-γ-primed-macrophages Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from trypanosoma cruzi Trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-γ-primed-macrophages Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from trypanosoma cruzi Trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-γ-primed-macrophages Journal of Leukocyte Biology, 71, 5, 837-844 Journal of Leukocyte Biology, 71, 5, 837-844 Journal of Leukocyte Biology, 71, 5, 837-844 2002/05/01 英語 研究論文(学術雑誌) 公開
R Tamai, T Sakuta, K Matsushita, M Torii, O Takeuchi, S Akira, S Akashi, T Espevik, S Sugawara, H Takada R Tamai, T Sakuta, K Matsushita, M Torii, O Takeuchi, S Akira, S Akashi, T Espevik, S Sugawara, H Takada R Tamai, T Sakuta, K Matsushita, M Torii, O Takeuchi, S Akira, S Akashi, T Espevik, S Sugawara, H Takada Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression INFECTION AND IMMUNITY, 70, 3, 1272-1278 INFECTION AND IMMUNITY, 70, 3, 1272-1278 INFECTION AND IMMUNITY, 70, 3, 1272-1278 2002/03 英語 研究論文(学術雑誌) 公開
Kumagai N, Tsuchimoto K, Tsunematsu S, Toda K, Takeuchi O, Saito H, Morizane T, Tsuchiya M, Ishii H Kumagai N, Tsuchimoto K, Tsunematsu S, Toda K, Takeuchi O, Saito H, Morizane T, Tsuchiya M, Ishii H Kumagai N, Tsuchimoto K, Tsunematsu S, Toda K, Takeuchi O, Saito H, Morizane T, Tsuchiya M, Ishii H Inhibition of growth of human hepatoma cells by dual-function antisense IL-6 oligonucleotides. Inhibition of growth of human hepatoma cells by dual-function antisense IL-6 oligonucleotides. Inhibition of growth of human hepatoma cells by dual-function antisense IL-6 oligonucleotides. Hepatology research : the official journal of the Japan Society of Hepatology, 22, 2, 119-126 Hepatology research : the official journal of the Japan Society of Hepatology, 22, 2, 119-126 Hepatology research : the official journal of the Japan Society of Hepatology, 22, 2, 119-126 2002/02 公開
M Saitoh, K Taguchi, K Momose, K Suga, N Yamazaki, C Ono, T Suzuki, O Takeuchi, S Yasuda, K Miyata M Saitoh, K Taguchi, K Momose, K Suga, N Yamazaki, C Ono, T Suzuki, O Takeuchi, S Yasuda, K Miyata M Saitoh, K Taguchi, K Momose, K Suga, N Yamazaki, C Ono, T Suzuki, O Takeuchi, S Yasuda, K Miyata Recombinant human interleukin-11 improved carboplatin-induced thrombocytopenia without affecting antitumor activities in mice bearing Lewis lung carcinoma cells Recombinant human interleukin-11 improved carboplatin-induced thrombocytopenia without affecting antitumor activities in mice bearing Lewis lung carcinoma cells Recombinant human interleukin-11 improved carboplatin-induced thrombocytopenia without affecting antitumor activities in mice bearing Lewis lung carcinoma cells CANCER CHEMOTHERAPY AND PHARMACOLOGY, 49, 2, 161-166 CANCER CHEMOTHERAPY AND PHARMACOLOGY, 49, 2, 161-166 CANCER CHEMOTHERAPY AND PHARMACOLOGY, 49, 2, 161-166 2002/02 英語 研究論文(学術雑誌) 公開
Kiyoshi Takeda, Osamu Takeuchi, Shizuo Akira Kiyoshi Takeda, Osamu Takeuchi, Shizuo Akira Kiyoshi Takeda, Osamu Takeuchi, Shizuo Akira Recognition of lipopeptides by Toll-like receptors Recognition of lipopeptides by Toll-like receptors Recognition of lipopeptides by Toll-like receptors Journal of Endotoxin Research, 8, 6, 459-463 Journal of Endotoxin Research, 8, 6, 459-463 Journal of Endotoxin Research, 8, 6, 459-463 2002 英語 研究論文(学術雑誌) 公開
Shintaro Sato, Osamu Takeuchi, Takashi Fujita, Hideyuki Tomizawa, Kiyoshi Takeda, Shizuo Akira Shintaro Sato, Osamu Takeuchi, Takashi Fujita, Hideyuki Tomizawa, Kiyoshi Takeda, Shizuo Akira Shintaro Sato, Osamu Takeuchi, Takashi Fujita, Hideyuki Tomizawa, Kiyoshi Takeda, Shizuo Akira A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways International Immunology, 14, 7, 783-791 International Immunology, 14, 7, 783-791 International Immunology, 14, 7, 783-791 2002 英語 研究論文(学術雑誌) 公開
Tsuneyasu Kaisho, Katsuaki Hoshino, Tomio Iwabe, Osamu Takeuchi, Teruhito Yasui, Shizuo Akira Tsuneyasu Kaisho, Katsuaki Hoshino, Tomio Iwabe, Osamu Takeuchi, Teruhito Yasui, Shizuo Akira Tsuneyasu Kaisho, Katsuaki Hoshino, Tomio Iwabe, Osamu Takeuchi, Teruhito Yasui, Shizuo Akira Endotoxin can induce MyD88-deficient dendritic cells to support T<inf>h</inf>2 cell differentiation Endotoxin can induce MyD88-deficient dendritic cells to support T<inf>h</inf>2 cell differentiation Endotoxin can induce MyD88-deficient dendritic cells to support T<inf>h</inf>2 cell differentiation International Immunology, 14, 7, 695-700 International Immunology, 14, 7, 695-700 International Immunology, 14, 7, 695-700 2002 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Genetic approaches to the study of Toll-like receptor function Genetic approaches to the study of Toll-like receptor function Genetic approaches to the study of Toll-like receptor function Microbes and Infection, 4, 9, 887-895 Microbes and Infection, 4, 9, 887-895 Microbes and Infection, 4, 9, 887-895 2002 英語 研究論文(学術雑誌) 公開
Hiroaki Hemmi, Tsuneyasu Kaisho, Osamu Takeuchi, Shintaro Sato, Hideki Sanjo, Katsuaki Hoshino, Takao Horiuchi, Hideyuki Tomizawa, Kiyoshi Takeda, Shizuo Akira Hiroaki Hemmi, Tsuneyasu Kaisho, Osamu Takeuchi, Shintaro Sato, Hideki Sanjo, Katsuaki Hoshino, Takao Horiuchi, Hideyuki Tomizawa, Kiyoshi Takeda, Shizuo Akira Hiroaki Hemmi, Tsuneyasu Kaisho, Osamu Takeuchi, Shintaro Sato, Hideki Sanjo, Katsuaki Hoshino, Takao Horiuchi, Hideyuki Tomizawa, Kiyoshi Takeda, Shizuo Akira Small-antiviral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway Small-antiviral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway Small-antiviral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway Nature Immunology, 3, 2, 196-200 Nature Immunology, 3, 2, 196-200 Nature Immunology, 3, 2, 196-200 2002 英語 研究論文(学術雑誌) 公開
Otaake Takeuchi, S. Akira Otaake Takeuchi, S. Akira Otaake Takeuchi, S. Akira MyD88 as a bottle neck in Toll/IL-1 signaling MyD88 as a bottle neck in Toll/IL-1 signaling MyD88 as a bottle neck in Toll/IL-1 signaling Current Topics in Microbiology and Immunology, 270, 155-167 Current Topics in Microbiology and Immunology, 270, 155-167 Current Topics in Microbiology and Immunology, 270, 155-167 2002 公開
Riyoko Tamai, Tetsuya Sakuta, Kenji Matsushita, Mitsuo Torii, Osamu Takeuchi, Shizuo Akira, Sachiko Akashi, Terje Espevik, Shunji Sugawara, Haruhiko Takada Riyoko Tamai, Tetsuya Sakuta, Kenji Matsushita, Mitsuo Torii, Osamu Takeuchi, Shizuo Akira, Sachiko Akashi, Terje Espevik, Shunji Sugawara, Haruhiko Takada Riyoko Tamai, Tetsuya Sakuta, Kenji Matsushita, Mitsuo Torii, Osamu Takeuchi, Shizuo Akira, Sachiko Akashi, Terje Espevik, Shunji Sugawara, Haruhiko Takada Human gingival CD14<sup>+</sup> fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression Human gingival CD14<sup>+</sup> fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression Human gingival CD14<sup>+</sup> fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression Infection and Immunity, 70, 3, 1272-1278 Infection and Immunity, 70, 3, 1272-1278 Infection and Immunity, 70, 3, 1272-1278 2002 英語 研究論文(学術雑誌) 公開
P. Henneke, O. Takeuchi, J. A. Van Strijp, H. K. Guttormsen, J. A. Smith, A. B. Schromm, T. A. Espevik, S. Akira, V. Nizet, D. L. Kasper, D. T. Golenbock P. Henneke, O. Takeuchi, J. A. Van Strijp, H. K. Guttormsen, J. A. Smith, A. B. Schromm, T. A. Espevik, S. Akira, V. Nizet, D. L. Kasper, D. T. Golenbock P. Henneke, O. Takeuchi, J. A. Van Strijp, H. K. Guttormsen, J. A. Smith, A. B. Schromm, T. A. Espevik, S. Akira, V. Nizet, D. L. Kasper, D. T. Golenbock Novel engagement of CD14 and multiple toll-like receptors by group B streptococci Novel engagement of CD14 and multiple toll-like receptors by group B streptococci Novel engagement of CD14 and multiple toll-like receptors by group B streptococci Journal of Immunology, 167, 12, 7069-7076 Journal of Immunology, 167, 12, 7069-7076 Journal of Immunology, 167, 12, 7069-7076 2001/12/15 英語 研究論文(学術雑誌) 公開
K. Adachi, H. Tsutsui, S. I. Kashiwamura, E. Seki, H. Nakano, O. Takeuchi, K. Takeda, K. Okumura, L. Van Kaer, H. Okamura, S. Akira, K. Nakanishi K. Adachi, H. Tsutsui, S. I. Kashiwamura, E. Seki, H. Nakano, O. Takeuchi, K. Takeda, K. Okumura, L. Van Kaer, H. Okamura, S. Akira, K. Nakanishi K. Adachi, H. Tsutsui, S. I. Kashiwamura, E. Seki, H. Nakano, O. Takeuchi, K. Takeda, K. Okumura, L. Van Kaer, H. Okamura, S. Akira, K. Nakanishi Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism Journal of Immunology, 167, 10, 5928-5934 Journal of Immunology, 167, 10, 5928-5934 Journal of Immunology, 167, 10, 5928-5934 2001/11/15 英語 研究論文(学術雑誌) 公開
T. Kawai, O. Takeuchi, T. Fujita, J. I. Inoue, P. F. Mühlradt, S. Sato, K. Hoshino, S. Akira T. Kawai, O. Takeuchi, T. Fujita, J. I. Inoue, P. F. Mühlradt, S. Sato, K. Hoshino, S. Akira T. Kawai, O. Takeuchi, T. Fujita, J. I. Inoue, P. F. Mühlradt, S. Sato, K. Hoshino, S. Akira Lipopolysaccharide stimulates the MyaD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes Lipopolysaccharide stimulates the MyaD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes Lipopolysaccharide stimulates the MyaD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes Journal of Immunology, 167, 10, 5887-5894 Journal of Immunology, 167, 10, 5887-5894 Journal of Immunology, 167, 10, 5887-5894 2001/11/15 英語 研究論文(学術雑誌) 公開
M. Nishiguchi, M. Matsumoto, T. Takao, M. Hoshino, Y. Shimonishi, S. Tsuji, N. A. Begum, O. Takeuchi, S. Akira, Y. Nishizawa, K. Toyoshima, T. Seya M. Nishiguchi, M. Matsumoto, T. Takao, M. Hoshino, Y. Shimonishi, S. Tsuji, N. A. Begum, O. Takeuchi, S. Akira, Y. Nishizawa, K. Toyoshima, T. Seya M. Nishiguchi, M. Matsumoto, T. Takao, M. Hoshino, Y. Shimonishi, S. Tsuji, N. A. Begum, O. Takeuchi, S. Akira, Y. Nishizawa, K. Toyoshima, T. Seya Erratum: Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by toll-like receptor 2: Role of N-terminal hydrophobic portion in its multiple functions (The Journal of Immunology (2001) 166 (2610-2616)) Erratum: Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by toll-like receptor 2: Role of N-terminal hydrophobic portion in its multiple functions (The Journal of Immunology (2001) 166 (2610-2616)) Erratum: Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by toll-like receptor 2: Role of N-terminal hydrophobic portion in its multiple functions (The Journal of Immunology (2001) 166 (2610-2616)) Journal of Immunology, 167, 6, 3530 Journal of Immunology, 167, 6, 3530 Journal of Immunology, 167, 6, 3530 2001/09/15 英語 研究論文(学術雑誌) 公開
M. A.S. Campos, I. C. Almeida, O. Takeuchi, S. Akira, E. P. Valente, D. O. Procópio, L. R. Travassos, J. A. Smith, D. T. Golenbock, R. T. Gazzinelli M. A.S. Campos, I. C. Almeida, O. Takeuchi, S. Akira, E. P. Valente, D. O. Procópio, L. R. Travassos, J. A. Smith, D. T. Golenbock, R. T. Gazzinelli M. A.S. Campos, I. C. Almeida, O. Takeuchi, S. Akira, E. P. Valente, D. O. Procópio, L. R. Travassos, J. A. Smith, D. T. Golenbock, R. T. Gazzinelli Activation of toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite Activation of toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite Activation of toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite Journal of Immunology, 167, 1, 416-423 Journal of Immunology, 167, 1, 416-423 Journal of Immunology, 167, 1, 416-423 2001/07/01 英語 研究論文(学術雑誌) 公開
T. Kaisho, O. Takeuchi, T. Kawai, K. Hoshino, S. Akira T. Kaisho, O. Takeuchi, T. Kawai, K. Hoshino, S. Akira T. Kaisho, O. Takeuchi, T. Kawai, K. Hoshino, S. Akira Endotoxin-induced maturation of MyD88-deficient dendritic cells Endotoxin-induced maturation of MyD88-deficient dendritic cells Endotoxin-induced maturation of MyD88-deficient dendritic cells Journal of Immunology, 166, 9, 5688-5694 Journal of Immunology, 166, 9, 5688-5694 Journal of Immunology, 166, 9, 5688-5694 2001/05/01 英語 研究論文(学術雑誌) 公開
S. Thoma-Uszynski, S. Stenger, O. Takeuchi, M. T. Ochoa, M. Engele, P. A. Sieling, P. F. Barnes, M. Röllinghoff, P. L. Bölcskei, M. Wagner, S. Akira, M. V. Norgard, J. T. Belisle, P. J. Godowski, B. R. Bloom, R. L. Modlin S. Thoma-Uszynski, S. Stenger, O. Takeuchi, M. T. Ochoa, M. Engele, P. A. Sieling, P. F. Barnes, M. Röllinghoff, P. L. Bölcskei, M. Wagner, S. Akira, M. V. Norgard, J. T. Belisle, P. J. Godowski, B. R. Bloom, R. L. Modlin S. Thoma-Uszynski, S. Stenger, O. Takeuchi, M. T. Ochoa, M. Engele, P. A. Sieling, P. F. Barnes, M. Röllinghoff, P. L. Bölcskei, M. Wagner, S. Akira, M. V. Norgard, J. T. Belisle, P. J. Godowski, B. R. Bloom, R. L. Modlin Induction of direct antimicrobial activity through mammalian toll-like receptors Induction of direct antimicrobial activity through mammalian toll-like receptors Induction of direct antimicrobial activity through mammalian toll-like receptors Science, 291, 5508, 1544-1547 Science, 291, 5508, 1544-1547 Science, 291, 5508, 1544-1547 2001/02/23 英語 研究論文(学術雑誌) 公開
E. Seki, H. Tsutsui, H. Nakano, N. M. Tsuji, K. Hoshino, O. Adachi, K. Adachi, S. Futatsugi, K. Kuida, O. Takeuchi, H. Okamura, J. Fujimoto, S. Akira, K. Nakanishi E. Seki, H. Tsutsui, H. Nakano, N. M. Tsuji, K. Hoshino, O. Adachi, K. Adachi, S. Futatsugi, K. Kuida, O. Takeuchi, H. Okamura, J. Fujimoto, S. Akira, K. Nakanishi E. Seki, H. Tsutsui, H. Nakano, N. M. Tsuji, K. Hoshino, O. Adachi, K. Adachi, S. Futatsugi, K. Kuida, O. Takeuchi, H. Okamura, J. Fujimoto, S. Akira, K. Nakanishi Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1β Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1β Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1β Journal of Immunology, 166, 4, 2651-2657 Journal of Immunology, 166, 4, 2651-2657 Journal of Immunology, 166, 4, 2651-2657 2001/02/15 英語 研究論文(学術雑誌) 公開
M. Nishiguchi, M. Matsumoto, T. Takao, M. Hoshino, Y. Shimonishi, S. Tsuji, N. A. Begum, O. Takeuchi, S. Akira, K. Toyoshima, T. Seya M. Nishiguchi, M. Matsumoto, T. Takao, M. Hoshino, Y. Shimonishi, S. Tsuji, N. A. Begum, O. Takeuchi, S. Akira, K. Toyoshima, T. Seya M. Nishiguchi, M. Matsumoto, T. Takao, M. Hoshino, Y. Shimonishi, S. Tsuji, N. A. Begum, O. Takeuchi, S. Akira, K. Toyoshima, T. Seya Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by toll-like receptor 2: Role of N-terminal hydrophobic portion in its multiple functions Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by toll-like receptor 2: Role of N-terminal hydrophobic portion in its multiple functions Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by toll-like receptor 2: Role of N-terminal hydrophobic portion in its multiple functions Journal of Immunology, 166, 4, 2610-2616 Journal of Immunology, 166, 4, 2610-2616 Journal of Immunology, 166, 4, 2610-2616 2001/02/15 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi, Taro Kawai, Peter F. Mühlradt, Michael Morr, Justin D. Radolf, Arturo Zychlinsky, Kiyoshi Takeda, Shizuo Akira Osamu Takeuchi, Taro Kawai, Peter F. Mühlradt, Michael Morr, Justin D. Radolf, Arturo Zychlinsky, Kiyoshi Takeda, Shizuo Akira Osamu Takeuchi, Taro Kawai, Peter F. Mühlradt, Michael Morr, Justin D. Radolf, Arturo Zychlinsky, Kiyoshi Takeda, Shizuo Akira Discrimination of bacterial lipoproteins by Toll-like recepttor 6 Discrimination of bacterial lipoproteins by Toll-like recepttor 6 Discrimination of bacterial lipoproteins by Toll-like recepttor 6 International Immunology, 13, 7, 933-940 International Immunology, 13, 7, 933-940 International Immunology, 13, 7, 933-940 2001 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Osamu Takeuchi, Shizuo Akira Toll-like receptors; their physiological role and signal transduction system Toll-like receptors; their physiological role and signal transduction system Toll-like receptors; their physiological role and signal transduction system International Immunopharmacology, 1, 4, 625-635 International Immunopharmacology, 1, 4, 625-635 International Immunopharmacology, 1, 4, 625-635 2001 英語 公開
S. Yang, R. Tamai, S. Akashi, O. Takeuchi, S. Akira, S. Sugawara, H. Takada S. Yang, R. Tamai, S. Akashi, O. Takeuchi, S. Akira, S. Sugawara, H. Takada S. Yang, R. Tamai, S. Akashi, O. Takeuchi, S. Akira, S. Sugawara, H. Takada Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture Infection and Immunity, 69, 4, 2045-2053 Infection and Immunity, 69, 4, 2045-2053 Infection and Immunity, 69, 4, 2045-2053 2001 英語 研究論文(学術雑誌) 公開
S. Sugawara, S. Yang, K. Iki, J. Hatakeyama, R. Tamai, O. Takeuchi, S. Akashi, T. Espevik, S. Akira, H. Takada S. Sugawara, S. Yang, K. Iki, J. Hatakeyama, R. Tamai, O. Takeuchi, S. Akashi, T. Espevik, S. Akira, H. Takada S. Sugawara, S. Yang, K. Iki, J. Hatakeyama, R. Tamai, O. Takeuchi, S. Akashi, T. Espevik, S. Akira, H. Takada Monocytic cell activation by nonendotoxic glycoprotein from Prevotella intermedia ATCC 25611 is mediated by toll-like receptor 2 Monocytic cell activation by nonendotoxic glycoprotein from Prevotella intermedia ATCC 25611 is mediated by toll-like receptor 2 Monocytic cell activation by nonendotoxic glycoprotein from Prevotella intermedia ATCC 25611 is mediated by toll-like receptor 2 Infection and Immunity, 69, 8, 4951-4957 Infection and Immunity, 69, 8, 4951-4957 Infection and Immunity, 69, 8, 4951-4957 2001 英語 研究論文(学術雑誌) 公開
S. Sato, F. Nomura, T. Kawai, O. Takeuchi, P. F. Muhlradt, K. Takeda, S. Akira S. Sato, F. Nomura, T. Kawai, O. Takeuchi, P. F. Muhlradt, K. Takeda, S. Akira S. Sato, F. Nomura, T. Kawai, O. Takeuchi, P. F. Muhlradt, K. Takeda, S. Akira Synergy and cross-tolerance between Toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways Synergy and cross-tolerance between Toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways Synergy and cross-tolerance between Toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways Journal of Immunology, 165, 12, 7096-7101 Journal of Immunology, 165, 12, 7096-7101 Journal of Immunology, 165, 12, 7096-7101 2000/12/15 英語 研究論文(学術雑誌) 公開
Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai, Tsuneyasu Kaisho, Shintaro Sato, Hideki Sanjo, Makoto Matsumoto, Katsuaki Hoshino, Hermann Wagner, Kiyoshi Takeda, Shizuo Akira Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai, Tsuneyasu Kaisho, Shintaro Sato, Hideki Sanjo, Makoto Matsumoto, Katsuaki Hoshino, Hermann Wagner, Kiyoshi Takeda, Shizuo Akira Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai, Tsuneyasu Kaisho, Shintaro Sato, Hideki Sanjo, Makoto Matsumoto, Katsuaki Hoshino, Hermann Wagner, Kiyoshi Takeda, Shizuo Akira A Toll-like receptor recognizes bacterial DNA A Toll-like receptor recognizes bacterial DNA A Toll-like receptor recognizes bacterial DNA Nature, 408, 6813, 740-745 Nature, 408, 6813, 740-745 Nature, 408, 6813, 740-745 2000/12/07 英語 研究論文(学術雑誌) 公開
O. Takeuchi, K. Hoshino, S. Akira O. Takeuchi, K. Hoshino, S. Akira O. Takeuchi, K. Hoshino, S. Akira Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection Journal of Immunology, 165, 10, 5392-5396 Journal of Immunology, 165, 10, 5392-5396 Journal of Immunology, 165, 10, 5392-5396 2000/11/15 英語 研究論文(学術雑誌) 公開
O. Takeuchi, A. Kaufmann, K. Grote, T. Kawai, K. Hoshino, M. Morr, P. F. Muhlradt, S. Akira O. Takeuchi, A. Kaufmann, K. Grote, T. Kawai, K. Hoshino, M. Morr, P. F. Muhlradt, S. Akira O. Takeuchi, A. Kaufmann, K. Grote, T. Kawai, K. Hoshino, M. Morr, P. F. Muhlradt, S. Akira Erratum: Cutting Edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway (Journal of Immunology (2000) 164 (554-557)) Erratum: Cutting Edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway (Journal of Immunology (2000) 164 (554-557)) Erratum: Cutting Edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway (Journal of Immunology (2000) 164 (554-557)) Journal of Immunology, 165, 10 Journal of Immunology, 165, 10 Journal of Immunology, 165, 10 2000/11/15 研究論文(学術雑誌) 公開
Hans Häcker, Ramunas M. Vabulas, Osamu Takeuchi, Katsuaki Hoshino, Shizuo Akira, Hermann Wagner Hans Häcker, Ramunas M. Vabulas, Osamu Takeuchi, Katsuaki Hoshino, Shizuo Akira, Hermann Wagner Hans Häcker, Ramunas M. Vabulas, Osamu Takeuchi, Katsuaki Hoshino, Shizuo Akira, Hermann Wagner Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6 Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6 Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6 Journal of Experimental Medicine, 192, 4, 595-600 Journal of Experimental Medicine, 192, 4, 595-600 Journal of Experimental Medicine, 192, 4, 595-600 2000/08/21 英語 研究論文(学術雑誌) 公開
Yasuji Mokuno, Tetsuya Matsuguchi, Manabu Takano, Hitoshi Nishimura, Junji Washizu, Tomohiko Ogawa, Osamu Takeuchi, Shizuo Akira, Yuji Nimura, Yasunobu Yoshikai Yasuji Mokuno, Tetsuya Matsuguchi, Manabu Takano, Hitoshi Nishimura, Junji Washizu, Tomohiko Ogawa, Osamu Takeuchi, Shizuo Akira, Yuji Nimura, Yasunobu Yoshikai Yasuji Mokuno, Tetsuya Matsuguchi, Manabu Takano, Hitoshi Nishimura, Junji Washizu, Tomohiko Ogawa, Osamu Takeuchi, Shizuo Akira, Yuji Nimura, Yasunobu Yoshikai Expression of toll-like receptor 2 on γδ T cells bearing invariant Vγ6/Vδ1 induced by Escherichia coli infection in mice Expression of toll-like receptor 2 on γδ T cells bearing invariant Vγ6/Vδ1 induced by Escherichia coli infection in mice Expression of toll-like receptor 2 on γδ T cells bearing invariant Vγ6/Vδ1 induced by Escherichia coli infection in mice Journal of Immunology, 165, 2, 931-940 Journal of Immunology, 165, 2, 931-940 Journal of Immunology, 165, 2, 931-940 2000/07/15 英語 研究論文(学術雑誌) 公開
Yoshimitsu Sakao, Taro Kawai, Osamu Takeuchi, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Kiyoshi Takeda, Shizuo Akira Yoshimitsu Sakao, Taro Kawai, Osamu Takeuchi, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Kiyoshi Takeda, Shizuo Akira Yoshimitsu Sakao, Taro Kawai, Osamu Takeuchi, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Kiyoshi Takeda, Shizuo Akira Mouse proteasomal ATPases Psmc3 and Psmc4: Genomic organization and gene targeting Mouse proteasomal ATPases Psmc3 and Psmc4: Genomic organization and gene targeting Mouse proteasomal ATPases Psmc3 and Psmc4: Genomic organization and gene targeting Genomics, 67, 1, 1-7 Genomics, 67, 1, 1-7 Genomics, 67, 1, 1-7 2000/07/01 英語 研究論文(学術雑誌) 公開
Masahito Hashimoto, Yoshimasa Imamura, Toshiyuki Morichika, Kazumi Arimoto, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira, Kazue Aoyama, Toshihide Tamura, Shozo Kotani, Yasuo Suda, Shoichi Kusumoto Masahito Hashimoto, Yoshimasa Imamura, Toshiyuki Morichika, Kazumi Arimoto, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira, Kazue Aoyama, Toshihide Tamura, Shozo Kotani, Yasuo Suda, Shoichi Kusumoto Masahito Hashimoto, Yoshimasa Imamura, Toshiyuki Morichika, Kazumi Arimoto, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira, Kazue Aoyama, Toshihide Tamura, Shozo Kotani, Yasuo Suda, Shoichi Kusumoto Cytokine-inducing macromolecular glycolipids from enterococcus hirae: Improved method for separation and analysis of its effects on cellular activation Cytokine-inducing macromolecular glycolipids from enterococcus hirae: Improved method for separation and analysis of its effects on cellular activation Cytokine-inducing macromolecular glycolipids from enterococcus hirae: Improved method for separation and analysis of its effects on cellular activation Biochemical and Biophysical Research Communications, 273, 1, 164-169 Biochemical and Biophysical Research Communications, 273, 1, 164-169 Biochemical and Biophysical Research Communications, 273, 1, 164-169 2000/06/24 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi, Andreas Kaufmann, Karsten Grote, Taro Kawai, Katsuaki Hoshino, Michael Morr, Peter F. Mühlradt, Shizuo Akira Osamu Takeuchi, Andreas Kaufmann, Karsten Grote, Taro Kawai, Katsuaki Hoshino, Michael Morr, Peter F. Mühlradt, Shizuo Akira Osamu Takeuchi, Andreas Kaufmann, Karsten Grote, Taro Kawai, Katsuaki Hoshino, Michael Morr, Peter F. Mühlradt, Shizuo Akira Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway Journal of Immunology, 164, 2, 554-557 Journal of Immunology, 164, 2, 554-557 Journal of Immunology, 164, 2, 554-557 2000/01/15 英語 研究論文(学術雑誌) 公開
Shoutaro Tsuji, Misako Matsumoto, Osamu Takeuchi, Shizuo Akira, Ichiro Azuma, Akira Hayashi, Kumao Toyoshima, Tsukasa Seya Shoutaro Tsuji, Misako Matsumoto, Osamu Takeuchi, Shizuo Akira, Ichiro Azuma, Akira Hayashi, Kumao Toyoshima, Tsukasa Seya Shoutaro Tsuji, Misako Matsumoto, Osamu Takeuchi, Shizuo Akira, Ichiro Azuma, Akira Hayashi, Kumao Toyoshima, Tsukasa Seya Maturation of human dendritic cells by cell wall skeleton of Mycobacterium boris bacillus Calmette-Guérin: Involvement of toll-like receptors Maturation of human dendritic cells by cell wall skeleton of Mycobacterium boris bacillus Calmette-Guérin: Involvement of toll-like receptors Maturation of human dendritic cells by cell wall skeleton of Mycobacterium boris bacillus Calmette-Guérin: Involvement of toll-like receptors Infection and Immunity, 68, 12, 6883-6890 Infection and Immunity, 68, 12, 6883-6890 Infection and Immunity, 68, 12, 6883-6890 2000 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi, Kiyoshi Takeda, Katsuaki Hoshino, Osamu Adachi, Tomohiko Ogawa, Shizuo Akira Osamu Takeuchi, Kiyoshi Takeda, Katsuaki Hoshino, Osamu Adachi, Tomohiko Ogawa, Shizuo Akira Osamu Takeuchi, Kiyoshi Takeda, Katsuaki Hoshino, Osamu Adachi, Tomohiko Ogawa, Shizuo Akira Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades International Immunology, 12, 1, 113-117 International Immunology, 12, 1, 113-117 International Immunology, 12, 1, 113-117 2000 英語 研究論文(学術雑誌) 公開
Osamu Takeuchi, Katsuaki Hoshino, Taro Kawai, Hideki Sanjo, Haruhiko Takada, Tomohiko Ogawa, Kiyoshi Takeda, Shizuo Akira Osamu Takeuchi, Katsuaki Hoshino, Taro Kawai, Hideki Sanjo, Haruhiko Takada, Tomohiko Ogawa, Kiyoshi Takeda, Shizuo Akira Osamu Takeuchi, Katsuaki Hoshino, Taro Kawai, Hideki Sanjo, Haruhiko Takada, Tomohiko Ogawa, Kiyoshi Takeda, Shizuo Akira Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components Immunity, 11, 4, 443-451 Immunity, 11, 4, 443-451 Immunity, 11, 4, 443-451 1999/10 英語 研究論文(学術雑誌) 公開
Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda, Shizuo Akira Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda, Shizuo Akira Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda, Shizuo Akira Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide evidence for TLR4 as the Lps gene product Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide evidence for TLR4 as the Lps gene product Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide evidence for TLR4 as the Lps gene product Journal of Immunology, 162, 7, 3749-3752 Journal of Immunology, 162, 7, 3749-3752 Journal of Immunology, 162, 7, 3749-3752 1999/04 英語 研究論文(学術雑誌) 公開
O. Takeuchi, T. Kawai, H. Sanjo, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, K. Takeda, S. Akira O. Takeuchi, T. Kawai, H. Sanjo, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, K. Takeda, S. Akira O. Takeuchi, T. Kawai, H. Sanjo, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, K. Takeda, S. Akira TLR6: A novel member of an expanding Toll-like receptor family TLR6: A novel member of an expanding Toll-like receptor family TLR6: A novel member of an expanding Toll-like receptor family Gene, 231, 1-2, 59-65 Gene, 231, 1-2, 59-65 Gene, 231, 1-2, 59-65 1999/04 英語 研究論文(学術雑誌) 公開

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著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Masanori Yoshinaga, Osamu Takeuchi Masanori Yoshinaga, Osamu Takeuchi Masanori Yoshinaga, Osamu Takeuchi RNA binding proteins in the control of autoimmune diseases RNA binding proteins in the control of autoimmune diseases RNA binding proteins in the control of autoimmune diseases Immunological Medicine, 42, 2, 53-64 Immunological Medicine, 42, 2, 53-64 Immunological Medicine, 42, 2, 53-64 2019/04 英語 書評、文献紹介等 公開
Masanori Yoshinaga, Osamu Takeuchi Masanori Yoshinaga, Osamu Takeuchi Masanori Yoshinaga, Osamu Takeuchi Post-transcriptional control of immune responses and its potential application Post-transcriptional control of immune responses and its potential application Post-transcriptional control of immune responses and its potential application Clinical and Translational Immunology, 8, 6, e1063 Clinical and Translational Immunology, 8, 6, e1063 Clinical and Translational Immunology, 8, 6, e1063 2019 英語 書評、文献紹介等 公開
Takuya Uehata, Daisuke Ori, Masaki Miyazaki, Hiroshi Kawamoto, Osamu Takeuchi Takuya Uehata, Daisuke Ori, Masaki Miyazaki, Hiroshi Kawamoto, Osamu Takeuchi Takuya Uehata, Daisuke Ori, Masaki Miyazaki, Hiroshi Kawamoto, Osamu Takeuchi Regnase-1 and Regnase-3 regulate cell fate of early lymphoid progenitors in the bone marrow Regnase-1 and Regnase-3 regulate cell fate of early lymphoid progenitors in the bone marrow Regnase-1 and Regnase-3 regulate cell fate of early lymphoid progenitors in the bone marrow 日本免疫学会学術集会, 2018年度 日本免疫学会学術集会, 2018年度 日本免疫学会学術集会, 2018年度 2018/12 公開
Yoshinari Nakatsuka, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Toyohiro Hirai Hirai, Osamu Takeuchi Yoshinari Nakatsuka, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Toyohiro Hirai Hirai, Osamu Takeuchi Yoshinari Nakatsuka, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Toyohiro Hirai Hirai, Osamu Takeuchi Pulmonary Regnase-1 functions as a posttranscriptional switch in anti-bacterial immunity Pulmonary Regnase-1 functions as a posttranscriptional switch in anti-bacterial immunity Pulmonary Regnase-1 functions as a posttranscriptional switch in anti-bacterial immunity CYTOKINE, 100, 39-39 CYTOKINE, 100, 39-39 CYTOKINE, 100, 39-39 2017/12 英語 研究発表要旨(国際会議) 公開
貞廣暁利, 足達俊吾, 深尾亜喜良, 船上仁範, 夏目徹, 竹内理, 藤原俊伸 貞廣暁利, 足達俊吾, 深尾亜喜良, 船上仁範, 夏目徹, 竹内理, 藤原俊伸 貞廣暁利, 足達俊吾, 深尾亜喜良, 船上仁範, 夏目徹, 竹内理, 藤原俊伸 ポリオウイルスの細胞種特異的なIRES依存的翻訳の解析 ポリオウイルスの細胞種特異的なIRES依存的翻訳の解析 ポリオウイルスの細胞種特異的なIRES依存的翻訳の解析 日本分子生物学会年会プログラム・要旨集(Web), 39th, ROMBUNNO.3LBA‐022 (WEB ONLY) 日本分子生物学会年会プログラム・要旨集(Web), 39th, ROMBUNNO.3LBA‐022 (WEB ONLY) 日本分子生物学会年会プログラム・要旨集(Web), 39th, ROMBUNNO.3LBA‐022 (WEB ONLY) 2016 日本語 公開
鍛代悠一, 織大祐, 末吉拓也, 川崎拓実, 竹内理, 松田正, 審良静男, 河合太郎 鍛代悠一, 織大祐, 末吉拓也, 川崎拓実, 竹内理, 松田正, 審良静男, 河合太郎 鍛代悠一, 織大祐, 末吉拓也, 川崎拓実, 竹内理, 松田正, 審良静男, 河合太郎 Arl5BによるMDA5依存的な抗ウイルス自然免疫応答の抑制機構の解明 Arl5BによるMDA5依存的な抗ウイルス自然免疫応答の抑制機構の解明 Arl5BによるMDA5依存的な抗ウイルス自然免疫応答の抑制機構の解明 日本薬学会年会要旨集(CD-ROM), 136th, ROMBUNNO.29AB‐AM249 日本薬学会年会要旨集(CD-ROM), 136th, ROMBUNNO.29AB‐AM249 日本薬学会年会要旨集(CD-ROM), 136th, ROMBUNNO.29AB‐AM249 2016 日本語 公開
Kazuya Masuda, Barry Ripley, Riko Nishimura, Takashi Mino, Osamu Takeuchi, Go Shioi, Hiroshi Kiyonari, Tadamitsu Kishimoto Kazuya Masuda, Barry Ripley, Riko Nishimura, Takashi Mino, Osamu Takeuchi, Go Shioi, Hiroshi Kiyonari, Tadamitsu Kishimoto Kazuya Masuda, Barry Ripley, Riko Nishimura, Takashi Mino, Osamu Takeuchi, Go Shioi, Hiroshi Kiyonari, Tadamitsu Kishimoto Arid5a contributes to stabilization of IL-6 mRNA, and elevation of IL-6 level in vivo Arid5a contributes to stabilization of IL-6 mRNA, and elevation of IL-6 level in vivo Arid5a contributes to stabilization of IL-6 mRNA, and elevation of IL-6 level in vivo CYTOKINE, 63, 3, 284-284 CYTOKINE, 63, 3, 284-284 CYTOKINE, 63, 3, 284-284 2013/09 英語 研究発表要旨(国際会議) 公開
Young Kang, Jianhui Ma, Eun-Jin Shim, Jiawei Lu, So-Young Eun, Mick Croft, Peter Tobias, Osamu Takeuchi, Shizuo Akira, Jiahuai Han, Michael Karin Young Kang, Jianhui Ma, Eun-Jin Shim, Jiawei Lu, So-Young Eun, Mick Croft, Peter Tobias, Osamu Takeuchi, Shizuo Akira, Jiahuai Han, Michael Karin Young Kang, Jianhui Ma, Eun-Jin Shim, Jiawei Lu, So-Young Eun, Mick Croft, Peter Tobias, Osamu Takeuchi, Shizuo Akira, Jiahuai Han, Michael Karin Regulation of 4-1BBL-mediated inflammation at the late phase of TLR response Regulation of 4-1BBL-mediated inflammation at the late phase of TLR response Regulation of 4-1BBL-mediated inflammation at the late phase of TLR response JOURNAL OF IMMUNOLOGY, 190 JOURNAL OF IMMUNOLOGY, 190 JOURNAL OF IMMUNOLOGY, 190 2013/05 英語 研究発表要旨(国際会議) 公開
Takeuchi O Takeuchi O Takeuchi O Posttranscriptional control of inflammation. Posttranscriptional control of inflammation. Posttranscriptional control of inflammation. (Session organizer), 炎症の分子生物学, 第35回日本分子生物学会年会, No. 4S8I, 福岡12 月11-14 日,2012. (Session organizer), 炎症の分子生物学, 第35回日本分子生物学会年会, No. 4S8I, 福岡12 月11-14 日,2012. (Session organizer), 炎症の分子生物学, 第35回日本分子生物学会年会, No. 4S8I, 福岡12 月11-14 日,2012. 2012 英語 公開
Takeuchi O Takeuchi O Takeuchi O O. Recognition of viral infection by innate immunity. O. Recognition of viral infection by innate immunity. O. Recognition of viral infection by innate immunity. Signle Topic Conference “Hepatitis C: Best Practice Based on Science", Tokyo, November 21-22, 2012 ・ Signle Topic Conference “Hepatitis C: Best Practice Based on Science", Tokyo, November 21-22, 2012 ・ Signle Topic Conference “Hepatitis C: Best Practice Based on Science", Tokyo, November 21-22, 2012 ・ 2012 英語 公開
竹内 理 竹内 理 生体の巧妙な炎症制御システムを探る 生体の巧妙な炎症制御システムを探る 第52 回生命科学夏の学校, 愛知,8 月25日,2012. 第52 回生命科学夏の学校, 愛知,8 月25日,2012. 2012 日本語 公開
竹内 理 竹内 理 自然免疫による炎症調節の分子機構 自然免疫による炎症調節の分子機構 2012 年度京都大学ウイルス研究所学術講 演会, 京都,7 月26 日,2012 2012 年度京都大学ウイルス研究所学術講 演会, 京都,7 月26 日,2012 2012 日本語 公開
竹内 理 竹内 理 RNA分解酵素Regnase-1 による自然免疫制御 RNA分解酵素Regnase-1 による自然免疫制御 日本生化学会大会, 福岡,12月16日2012 日本生化学会大会, 福岡,12月16日2012 2012 日本語 公開
竹内 理 竹内 理 自然免疫における炎症の転写後調節メカニズム 自然免疫における炎症の転写後調節メカニズム 第9 回ウイルス学キャンプin 湯河原、7月、2012 第9 回ウイルス学キャンプin 湯河原、7月、2012 2012 日本語 公開
Akira R. Kinjo, Yutaro Kumagai, Huy Dinh, Osamu Takeuchi, Daron M. Standley Akira R. Kinjo, Yutaro Kumagai, Huy Dinh, Osamu Takeuchi, Daron M. Standley Akira R. Kinjo, Yutaro Kumagai, Huy Dinh, Osamu Takeuchi, Daron M. Standley Functional characterization of protein domains common to animal viruses and mouse Functional characterization of protein domains common to animal viruses and mouse Functional characterization of protein domains common to animal viruses and mouse 10th Int. Conference on Bioinformatics - 1st ISCB Asia Joint Conference 2011, InCoB 2011/ISCB-Asia 2011: Computational Biology - Proceedings from Asia Pacific Bioinformatics Network (APBioNet), 12, SUPPL. 3 10th Int. Conference on Bioinformatics - 1st ISCB Asia Joint Conference 2011, InCoB 2011/ISCB-Asia 2011: Computational Biology - Proceedings from Asia Pacific Bioinformatics Network (APBioNet), 12, SUPPL. 3 10th Int. Conference on Bioinformatics - 1st ISCB Asia Joint Conference 2011, InCoB 2011/ISCB-Asia 2011: Computational Biology - Proceedings from Asia Pacific Bioinformatics Network (APBioNet), 12, SUPPL. 3 2011 英語 公開
竹内 理 竹内 理 TAKEUCHI Osamu mRNA安定性制御による免疫応答調節機構 mRNA安定性制御による免疫応答調節機構 Regulation of immune responses by mRNA stability control 生化學, 82, 12, 1124-1128 生化學, 82, 12, 1124-1128 , 82, 12, 1124-1128 2010/12/25 日本語 公開
三宅 亨, 加藤 博己, 竹内 理, 審良 静男, 谷 徹 三宅 亨, 加藤 博己, 竹内 理, 審良 静男, 谷 徹 OP-047-1 Poly I: C-induced anti-tumor effect of NK cells in CD8α^+dendritic cells via the IPS-1 and TRIF-dependent pathways(免疫-3,一般口演,第110回日本外科学会定期学術集会) OP-047-1 Poly I: C-induced anti-tumor effect of NK cells in CD8α^+dendritic cells via the IPS-1 and TRIF-dependent pathways(免疫-3,一般口演,第110回日本外科学会定期学術集会) 日本外科学会雑誌, 111, 2 日本外科学会雑誌, 111, 2 , 111, 2 2010/03/05 日本語 公開
三宅 亨, 加藤 博己, 竹内 理, 審良 静男, 谷 徹 三宅 亨, 加藤 博己, 竹内 理, 審良 静男, 谷 徹 三宅 亨, 加藤 博己, 竹内 理, 審良 静男, 谷 徹 IPS-1とTRIF-経路によるCD8α+樹状細胞におけるNK細胞のPoly I:C誘発性抗腫瘍効果(Poly I: C-induced anti-tumor effect of NK cells in CD8α+dendritic cells via the IPS-1 and TRIF-dependent pathways) IPS-1とTRIF-経路によるCD8α+樹状細胞におけるNK細胞のPoly I:C誘発性抗腫瘍効果(Poly I: C-induced anti-tumor effect of NK cells in CD8α+dendritic cells via the IPS-1 and TRIF-dependent pathways) IPS-1とTRIF-経路によるCD8α+樹状細胞におけるNK細胞のPoly I:C誘発性抗腫瘍効果(Poly I: C-induced anti-tumor effect of NK cells in CD8α+dendritic cells via the IPS-1 and TRIF-dependent pathways) 日本外科学会雑誌, 111, 臨増2, 362-362 日本外科学会雑誌, 111, 臨増2, 362-362 日本外科学会雑誌, 111, 臨増2, 362-362 2010/03 日本語 公開
松下 一史, 竹内 理, 審良 静男 松下 一史, 竹内 理, 審良 静男 松下 一史, 竹内 理, 審良 静男 自然免疫と自己免疫疾患 自然免疫と自己免疫疾患 自然免疫と自己免疫疾患 炎症と免疫, 18, 1, 69-74 炎症と免疫, 18, 1, 69-74 炎症と免疫, 18, 1, 69-74 2009/12 日本語 公開
竹内 理, 松下 一史, 審良 静男 竹内 理, 松下 一史, 審良 静男 竹内 理, 松下 一史, 審良 静男 自然免疫における遺伝子発現制御 新規リボヌクレアーゼによる炎症応答の調節 自然免疫における遺伝子発現制御 新規リボヌクレアーゼによる炎症応答の調節 自然免疫における遺伝子発現制御 新規リボヌクレアーゼによる炎症応答の調節 蛋白質・核酸・酵素, 54, 14, 1837-1841 蛋白質・核酸・酵素, 54, 14, 1837-1841 蛋白質・核酸・酵素, 54, 14, 1837-1841 2009/11 日本語 公開
齊藤 達哉, 藤田 尚信, 張 明浩, 植松 智, 梁 甫伎, 佐藤 荘, 大森 弘子, 野田 健司, 山本 直樹, 小松 雅明, 田中 啓二, 河合 太郎, 辻村 亨, 竹内 理, 吉森 保, 審良 静男 齊藤 達哉, 藤田 尚信, 張 明浩, 植松 智, 梁 甫伎, 佐藤 荘, 大森 弘子, 野田 健司, 山本 直樹, 小松 雅明, 田中 啓二, 河合 太郎, 辻村 亨, 竹内 理, 吉森 保, 審良 静男 齊藤 達哉, 藤田 尚信, 張 明浩, 植松 智, 梁 甫伎, 佐藤 荘, 大森 弘子, 野田 健司, 山本 直樹, 小松 雅明, 田中 啓二, 河合 太郎, 辻村 亨, 竹内 理, 吉森 保, 審良 静男 タンパク質分解を介した新たな生理機能 オートファジー関連分子Atg16L1はエンドトキシンによるインフラマソーム活性化を制御する(Atg16L1, an autophagy protein, controls endotoxin-induced inflammasome activation) タンパク質分解を介した新たな生理機能 オートファジー関連分子Atg16L1はエンドトキシンによるインフラマソーム活性化を制御する(Atg16L1, an autophagy protein, controls endotoxin-induced inflammasome activation) タンパク質分解を介した新たな生理機能 オートファジー関連分子Atg16L1はエンドトキシンによるインフラマソーム活性化を制御する(Atg16L1, an autophagy protein, controls endotoxin-induced inflammasome activation) 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 81回・31回, 4S3-7 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 81回・31回, 4S3-7 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 81回・31回, 4S3-7 2008/11 英語 公開
竹内 理, 審良 静男 竹内 理, 審良 静男 S2-01 自然免疫によるRNAウイルス認識機構(シンポジウム2 和漢薬と生体防御,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-) S2-01 自然免疫によるRNAウイルス認識機構(シンポジウム2 和漢薬と生体防御,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-) 和漢医薬学雑誌, 24, 0 和漢医薬学雑誌, 24, 0 , 24, 0 2007/08/20 日本語 公開
竹内 理, 審良 静男 竹内 理, 審良 静男 Takeuchi Osamu, Akira Shizuo 自然免疫による病原体認識 自然免疫による病原体認識 PATHOGEN RECOGNITION BY INNATE IMMUNITY アレルギー, 56, 6, 558-562 アレルギー, 56, 6, 558-562 Japanese Journal of Allergology, 56, 6, 558-562 2007/06/30 日本語 公開
熊谷 雄太郎, 竹内 理, 審良 静男 熊谷 雄太郎, 竹内 理, 審良 静男 自然免疫--システム生物学的アプローチの果たしうる役割 (第1土曜特集 システム生物医学) -- (疾患のシステム生物医学) 自然免疫--システム生物学的アプローチの果たしうる役割 (第1土曜特集 システム生物医学) -- (疾患のシステム生物医学) 医学のあゆみ, 219, 9, 707-713 医学のあゆみ, 219, 9, 707-713 , 219, 9, 707-713 2006/12/02 日本語 公開
植松 智, 佐藤 慎太郎, 山本 雅裕, 加藤 博己, 石井 健, 河合 太郎, 竹内 理, 審良 静男 植松 智, 佐藤 慎太郎, 山本 雅裕, 加藤 博己, 石井 健, 河合 太郎, 竹内 理, 審良 静男 植松 智, 佐藤 慎太郎, 山本 雅裕, 加藤 博己, 石井 健, 河合 太郎, 竹内 理, 審良 静男 IRAK-1はTLR7とTLR9を解するIFN-α産生に必須の役割を果たす IRAK-1はTLR7とTLR9を解するIFN-α産生に必須の役割を果たす IRAK-1はTLR7とTLR9を解するIFN-α産生に必須の役割を果たす 日本免疫学会総会・学術集会記録, 35, 47-47 日本免疫学会総会・学術集会記録, 35, 47-47 日本免疫学会総会・学術集会記録, 35, 47-47 2005/11 日本語 公開
坂尾 宣充, 植松 智, 竹内 理, 安居 輝人, 竹田 潔, 改正 恒康, 審良 静男 坂尾 宣充, 植松 智, 竹内 理, 安居 輝人, 竹田 潔, 改正 恒康, 審良 静男 坂尾 宣充, 植松 智, 竹内 理, 安居 輝人, 竹田 潔, 改正 恒康, 審良 静男 マウスstrawberry notch homologue遺伝子の解析 マウスstrawberry notch homologue遺伝子の解析 マウスstrawberry notch homologue遺伝子の解析 日本免疫学会総会・学術集会記録, 35, 60-60 日本免疫学会総会・学術集会記録, 35, 60-60 日本免疫学会総会・学術集会記録, 35, 60-60 2005/11 日本語 公開
改正 恒康, 邊見 弘明, 山本 雅裕, 竹内 理, 星野 克明, 審良 静男 改正 恒康, 邊見 弘明, 山本 雅裕, 竹内 理, 星野 克明, 審良 静男 改正 恒康, 邊見 弘明, 山本 雅裕, 竹内 理, 星野 克明, 審良 静男 2本鎖RNAにより活性化されるTLR3依存性,非依存性経路の機能的相違 2本鎖RNAにより活性化されるTLR3依存性,非依存性経路の機能的相違 2本鎖RNAにより活性化されるTLR3依存性,非依存性経路の機能的相違 日本免疫学会総会・学術集会記録, 34, 200-200 日本免疫学会総会・学術集会記録, 34, 200-200 日本免疫学会総会・学術集会記録, 34, 200-200 2004/11 日本語 公開
河合 太郎, 佐藤 慎太郎, 石井 健, Coban Cevayir, 辺見 弘明, 山本 雅裕, 植松 智, 竹内 理, 審良 静男 河合 太郎, 佐藤 慎太郎, 石井 健, Coban Cevayir, 辺見 弘明, 山本 雅裕, 植松 智, 竹内 理, 審良 静男 河合 太郎, 佐藤 慎太郎, 石井 健, Coban Cevayir, 辺見 弘明, 山本 雅裕, 植松 智, 竹内 理, 審良 静男 Toll様受容体を介したI型IFN産生誘導のメカニズム Toll様受容体を介したI型IFN産生誘導のメカニズム Toll様受容体を介したI型IFN産生誘導のメカニズム 日本免疫学会総会・学術集会記録, 34, 51-51 日本免疫学会総会・学術集会記録, 34, 51-51 日本免疫学会総会・学術集会記録, 34, 51-51 2004/11 日本語 公開
植松 智, 佐藤 慎太郎, 山本 雅裕, 加藤 博己, 石井 健, 河合 太郎, 竹内 理, 審良 静男 植松 智, 佐藤 慎太郎, 山本 雅裕, 加藤 博己, 石井 健, 河合 太郎, 竹内 理, 審良 静男 植松 智, 佐藤 慎太郎, 山本 雅裕, 加藤 博己, 石井 健, 河合 太郎, 竹内 理, 審良 静男 Plasmacytoid DCにおけるToll-like receptor 9によるtype Iインターフェロンの誘導機構 Plasmacytoid DCにおけるToll-like receptor 9によるtype Iインターフェロンの誘導機構 Plasmacytoid DCにおけるToll-like receptor 9によるtype Iインターフェロンの誘導機構 日本免疫学会総会・学術集会記録, 34, 52-52 日本免疫学会総会・学術集会記録, 34, 52-52 日本免疫学会総会・学術集会記録, 34, 52-52 2004/11 日本語 公開
加藤 博己, 佐藤 慎太郎, 山本 雅裕, 松井 孝介, 植松 智, 竹田 潔, 竹内 理, 審良 静男 加藤 博己, 佐藤 慎太郎, 山本 雅裕, 松井 孝介, 植松 智, 竹田 潔, 竹内 理, 審良 静男 加藤 博己, 佐藤 慎太郎, 山本 雅裕, 松井 孝介, 植松 智, 竹田 潔, 竹内 理, 審良 静男 RIG-I欠損マウスの作成および解析 RIG-I欠損マウスの作成および解析 RIG-I欠損マウスの作成および解析 日本免疫学会総会・学術集会記録, 34, 62-62 日本免疫学会総会・学術集会記録, 34, 62-62 日本免疫学会総会・学術集会記録, 34, 62-62 2004/11 日本語 公開
竹内 理, 審良 静男 竹内 理, 審良 静男 Osamu Takeuchi, Shizuo Akira Toll-like receptor の生体防御における役割とそのシグナル伝達機構 Toll-like receptor の生体防御における役割とそのシグナル伝達機構 Roles of Toll-like receptor in host defense and the mechanism of its signal transduction 日本細菌学雑誌, 59, 4, 523-529 日本細菌学雑誌, 59, 4, 523-529 Nippon saikingaku zasshi. Japanese journal of bacteriology, 59, 4, 523-529 2004/11 日本語 書評、文献紹介等 公開
宍戸 哲郎, 野崎 直樹, 二藤部 丈司, 宮本 卓也, 高橋 大, 有本 貴範, 竹石 恭知, 久保田 功, 山口 清司, 竹内 理, 審良 静男 宍戸 哲郎, 野崎 直樹, 二藤部 丈司, 宮本 卓也, 高橋 大, 有本 貴範, 竹石 恭知, 久保田 功, 山口 清司, 竹内 理, 審良 静男 Toll-like 2 Modulates Ventricular Remodeling After Myocardial Infarction Toll-like 2 Modulates Ventricular Remodeling After Myocardial Infarction Toll-like 2 Modulates Ventricular Remodeling After Myocardial Infarction Circulation journal : official journal of the Japanese Circulation Society, 67, 0 Circulation journal : official journal of the Japanese Circulation Society, 67, 0 Circulation journal : official journal of the Japanese Circulation Society, 67, 0 2003/10/20 日本語 公開
改正 恒康, 星野 克明, 竹内 理, 岩部 富夫, 審良 静男 改正 恒康, 星野 克明, 竹内 理, 岩部 富夫, 審良 静男 改正 恒康, 星野 克明, 竹内 理, 岩部 富夫, 審良 静男 TLR4刺激MyD88欠損樹状細胞のTh2細胞分化支持能の解析 TLR4刺激MyD88欠損樹状細胞のTh2細胞分化支持能の解析 TLR4刺激MyD88欠損樹状細胞のTh2細胞分化支持能の解析 日本免疫学会総会・学術集会記録, 32, 55-55 日本免疫学会総会・学術集会記録, 32, 55-55 日本免疫学会総会・学術集会記録, 32, 55-55 2002/10 日本語 公開
邊見 弘明, 改正 恒康, 竹内 理, 星野 克明, 竹田 潔, 審良 静男 邊見 弘明, 改正 恒康, 竹内 理, 星野 克明, 竹田 潔, 審良 静男 邊見 弘明, 改正 恒康, 竹内 理, 星野 克明, 竹田 潔, 審良 静男 各種DNAによる細胞活性化におけるTLR9の役割の検討 各種DNAによる細胞活性化におけるTLR9の役割の検討 各種DNAによる細胞活性化におけるTLR9の役割の検討 日本免疫学会総会・学術集会記録, 31, 231-231 日本免疫学会総会・学術集会記録, 31, 231-231 日本免疫学会総会・学術集会記録, 31, 231-231 2001/12 日本語 公開
星野 克明, 岩部 富夫, 竹内 理, 改正 恒康, 審良 静男 星野 克明, 岩部 富夫, 竹内 理, 改正 恒康, 審良 静男 星野 克明, 岩部 富夫, 竹内 理, 改正 恒康, 審良 静男 マウス樹状細胞におけるToll-like receptorを介した遺伝子発現機構の解析 マウス樹状細胞におけるToll-like receptorを介した遺伝子発現機構の解析 マウス樹状細胞におけるToll-like receptorを介した遺伝子発現機構の解析 日本免疫学会総会・学術集会記録, 31, 231-231 日本免疫学会総会・学術集会記録, 31, 231-231 日本免疫学会総会・学術集会記録, 31, 231-231 2001/12 日本語 公開
改正 恒康, 星野 克明, 竹内 理, 岩部 富夫, 竹田 潔, 審良 静男 改正 恒康, 星野 克明, 竹内 理, 岩部 富夫, 竹田 潔, 審良 静男 改正 恒康, 星野 克明, 竹内 理, 岩部 富夫, 竹田 潔, 審良 静男 LPS刺激MyD88欠損樹状細胞はTH2細胞分化支持能を有する LPS刺激MyD88欠損樹状細胞はTH2細胞分化支持能を有する LPS刺激MyD88欠損樹状細胞はTH2細胞分化支持能を有する 日本免疫学会総会・学術集会記録, 31, 257-257 日本免疫学会総会・学術集会記録, 31, 257-257 日本免疫学会総会・学術集会記録, 31, 257-257 2001/12 日本語 公開
石 亦宏, 筒井 ひろ子, 辻 典子, 中埜 広樹, 安達 圭志, 竹内 理, 星野 克明, 審良 静男, 岡村 春樹, 藤元 治朗 石 亦宏, 筒井 ひろ子, 辻 典子, 中埜 広樹, 安達 圭志, 竹内 理, 星野 克明, 審良 静男, 岡村 春樹, 藤元 治朗 石 亦宏, 筒井 ひろ子, 辻 典子, 中埜 広樹, 安達 圭志, 竹内 理, 星野 克明, 審良 静男, 岡村 春樹, 藤元 治朗 自然免疫系活性化によるListeria monocytogenesの排除機構 自然免疫系活性化によるListeria monocytogenesの排除機構 自然免疫系活性化によるListeria monocytogenesの排除機構 日本免疫学会総会・学術集会記録, 31, 125-125 日本免疫学会総会・学術集会記録, 31, 125-125 日本免疫学会総会・学術集会記録, 31, 125-125 2001/12 日本語 公開
岡本 正人, 大江 剛, 押川 哲也, 古市 幸子, 西川 英知, 田野 智之, シャリフ・ウディン・アーメッド, 竹内 理, 審良 静男, 赤司 祥子 岡本 正人, 大江 剛, 押川 哲也, 古市 幸子, 西川 英知, 田野 智之, シャリフ・ウディン・アーメッド, 竹内 理, 審良 静男, 赤司 祥子 岡本 正人, 大江 剛, 押川 哲也, 古市 幸子, 西川 英知, 田野 智之, シャリフ・ウディン・アーメッド, 竹内 理, 審良 静男, 赤司 祥子 OK-432由来複合糖質のToll-like receptor 4を介した抗腫瘍免疫増強効果 OK-432由来複合糖質のToll-like receptor 4を介した抗腫瘍免疫増強効果 OK-432由来複合糖質のToll-like receptor 4を介した抗腫瘍免疫増強効果 日本癌学会総会記事, 60回, 242-242 日本癌学会総会記事, 60回, 242-242 日本癌学会総会記事, 60回, 242-242 2001/09 日本語 公開
邊見 弘明, 竹内 理, 河合 太郎, 改正 恒康, 佐藤 慎太郎, 山条 秀樹, 星野 克明, 竹田 潔, 審良 静男 邊見 弘明, 竹内 理, 河合 太郎, 改正 恒康, 佐藤 慎太郎, 山条 秀樹, 星野 克明, 竹田 潔, 審良 静男 邊見 弘明, 竹内 理, 河合 太郎, 改正 恒康, 佐藤 慎太郎, 山条 秀樹, 星野 克明, 竹田 潔, 審良 静男 バクテリア由来非メチル化DNAによる免疫応答に必須なToll-like receptorの同定 バクテリア由来非メチル化DNAによる免疫応答に必須なToll-like receptorの同定 バクテリア由来非メチル化DNAによる免疫応答に必須なToll-like receptorの同定 日本免疫学会総会・学術集会記録, 30, 71-71 日本免疫学会総会・学術集会記録, 30, 71-71 日本免疫学会総会・学術集会記録, 30, 71-71 2000/11 日本語 公開
改正 恒康, 竹内 理, 河合 太郎, 星野 克明, 審良 静男 改正 恒康, 竹内 理, 河合 太郎, 星野 克明, 審良 静男 改正 恒康, 竹内 理, 河合 太郎, 星野 克明, 審良 静男 MyD88欠損樹状細胞はエンドトキシン刺激により機能的に成熟する MyD88欠損樹状細胞はエンドトキシン刺激により機能的に成熟する MyD88欠損樹状細胞はエンドトキシン刺激により機能的に成熟する 日本免疫学会総会・学術集会記録, 30, 128-128 日本免疫学会総会・学術集会記録, 30, 128-128 日本免疫学会総会・学術集会記録, 30, 128-128 2000/11 日本語 公開
佐藤 慎太郎, 河合 太郎, 星野 克明, 竹内 理, 審良 静男 佐藤 慎太郎, 河合 太郎, 星野 克明, 竹内 理, 審良 静男 佐藤 慎太郎, 河合 太郎, 星野 克明, 竹内 理, 審良 静男 MyD88を介さない新たなLPSシグナル伝達機構 MyD88を介さない新たなLPSシグナル伝達機構 MyD88を介さない新たなLPSシグナル伝達機構 日本免疫学会総会・学術集会記録, 30, 226-226 日本免疫学会総会・学術集会記録, 30, 226-226 日本免疫学会総会・学術集会記録, 30, 226-226 2000/11 日本語 公開
PY Perera, TN Mayadas, O Takeuchi, S Akira, M Zaks-Zilberman, SM Goyert, SN Vogel PY Perera, TN Mayadas, O Takeuchi, S Akira, M Zaks-Zilberman, SM Goyert, SN Vogel PY Perera, TN Mayadas, O Takeuchi, S Akira, M Zaks-Zilberman, SM Goyert, SN Vogel Interaction of CD14, CD11b/CD18, and TLR4 is required for full LPS- and Taxol-inducible gene expression Interaction of CD14, CD11b/CD18, and TLR4 is required for full LPS- and Taxol-inducible gene expression Interaction of CD14, CD11b/CD18, and TLR4 is required for full LPS- and Taxol-inducible gene expression JOURNAL OF LEUKOCYTE BIOLOGY, 31-31 JOURNAL OF LEUKOCYTE BIOLOGY, 31-31 JOURNAL OF LEUKOCYTE BIOLOGY, 31-31 2000 英語 研究発表要旨(国際会議) 公開
竹内 理, 星野 克明, 足達 治, 小川 知彦, 竹田 潔, 審良 静男 竹内 理, 星野 克明, 足達 治, 小川 知彦, 竹田 潔, 審良 静男 竹内 理, 星野 克明, 足達 治, 小川 知彦, 竹田 潔, 審良 静男 MyD88は様々な細菌菌体成分に対する反応に必須である MyD88は様々な細菌菌体成分に対する反応に必須である MyD88は様々な細菌菌体成分に対する反応に必須である 日本免疫学会総会・学術集会記録, 29, 237-237 日本免疫学会総会・学術集会記録, 29, 237-237 日本免疫学会総会・学術集会記録, 29, 237-237 1999/10 日本語 公開
星野 克明, 竹内 理, 河合 太郎, 山条 秀樹, 小川 知彦, 竹田 潔, 審良 静男 星野 克明, 竹内 理, 河合 太郎, 山条 秀樹, 小川 知彦, 竹田 潔, 審良 静男 星野 克明, 竹内 理, 河合 太郎, 山条 秀樹, 小川 知彦, 竹田 潔, 審良 静男 TLR4(Toll like receptor 4)欠損マウスの作成と解析 TLR4(Toll like receptor 4)欠損マウスの作成と解析 TLR4(Toll like receptor 4)欠損マウスの作成と解析 日本免疫学会総会・学術集会記録, 29, 198-198 日本免疫学会総会・学術集会記録, 29, 198-198 日本免疫学会総会・学術集会記録, 29, 198-198 1999/10 日本語 公開
Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S Limb and skin abnormalities in mice lacking IKKα Limb and skin abnormalities in mice lacking IKKα Limb and skin abnormalities in mice lacking IKKα Science, 284, 5412, 313-316 Science, 284, 5412, 313-316 Science, 284, 5412, 313-316 1999 公開

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タイトル言語:
産業財産権 (特許)
発明者 発明者(日本語) 発明者(英語) 発明の名称 発明の名称(日本語) 発明の名称(英語) 審査の段階 番号 年月 公開
深坂 昌弘, 岡崎 有道, 浅利 大介, 堀 光彦, 審良 静男, 竹内 理 深坂 昌弘, 岡崎 有道, 浅利 大介, 堀 光彦, 審良 静男, 竹内 理 ワクチン組成物 ワクチン組成物 特許登録 特許第5650780号 2014/11/21 公開
審良 静男, 竹内 理, 佐藤 荘 審良 静男, 竹内 理, 佐藤 荘 Jmjd3遺伝子改変非ヒト哺乳動物、Jmjd3遺伝子改変骨髄キメラ非ヒト哺乳動物、及びその利用 Jmjd3遺伝子改変非ヒト哺乳動物、Jmjd3遺伝子改変骨髄キメラ非ヒト哺乳動物、及びその利用 特許公開 特開2012-019768 2012/02/02 公開
審良 静男, 竹内 理 審良 静男, 竹内 理 マイコプラズマ由来リポタンパク/リポペプチド不応答性モデル非ヒト動物 マイコプラズマ由来リポタンパク/リポペプチド不応答性モデル非ヒト動物 特許登録 特許第4236692号 2008/12/26 公開
審良 静男, 竹内 理, 竹田 潔 審良 静男, 竹内 理, 竹田 潔 細菌菌体成分不応答性モデルマウス 細菌菌体成分不応答性モデルマウス 特許登録 特許第4197580号 2008/10/10 公開
タイトル言語:
学術賞等
賞の名称(日本語) 賞の名称(英語) 授与組織名(日本語) 授与組織名(英語) 年月
日本免疫学会研究奨励賞 日本免疫学会 Japanese Society for Immunology 2008/12/03
日本学術振興会賞 JSPS Prize 日本学術振興会 JSPS 2016/02/24
日本学士院学術奨励賞 Japan Academy Medal 日本学士院 Japan Academy 2016/02/24
外部資金:競争的資金 (科学研究費補助金)
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
若手研究(A) 代表 RNA分解酵素Zc3h12aによる免疫制御機構の解析 2012〜2012
基盤研究(A) 代表 mRNA分解の時空間制御による免疫応答調節機構の解明 (平成30年度分) 2018/04/01〜2019/03/31
基盤研究(S) 代表 mRNA代謝が司る免疫制御機構の解明 (平成30年度分) 2018/04/01〜2019/03/31
基盤研究(S) 代表 mRNA代謝が司る免疫制御機構の解明 (2019年度分) 2019/04/01〜2020/03/31
外部資金:競争的資金 (科学研究費補助金以外)
制度名 代表者名 研究課題(日本語) 研究課題(英語) 期間
日本学術振興会 最先端研究開発支援プログラム 竹内 理 2010〜2013
日本学術振興会・最先端・次世代研究開発支援プログラム(平成24年度研究費) 免疫ダイナミズムの統合的理解と免疫制御法の確立 2012〜2012
JST, CREST 竹内 理 自然免疫における転写後調節を介した慢性炎症抑制メカニズムの解析 2012/10/01〜2018/03/31
革新的先端研究開発支援事業 竹内 理 RNA結合蛋白質のヒト炎症性疾患への関連性解明とその制御法開発 2019/04/01〜2021/03/31
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
ウイルスと生命科学 Virus and Life Science 後期 全学共通科目 2013/04〜2014/03
生命科学研究の第一線に立つII The Front Line of Life Science Research II 前期 全学共通科目 2013/04〜2014/03
ウイルスと生命科学 Virus and Life Science 後期 全学共通科目 2014/04〜2015/03
生命科学研究の第一線に立つII The Front Line of Life Science Research II 前期 全学共通科目 2014/04〜2015/03
ウイルスと生命科学 Virus and Life Science 後期 全学共通科目 2015/04〜2016/03
生命科学研究の第一線に立つII The Front Line of Life Science Research II 前期 全学共通科目 2015/04〜2016/03
疾患・免疫生命科学特論 Advanced Course in Immunology and Human Disorders 後期集中 生命科学研究科 2015/04〜2016/03
先端生命科学 Frontier in Life Sciences 後期集中 生命科学研究科 2016/04〜2017/03
医科学特論 Basic Introduction in Medical Science 前期不定 医学研究科 2016/04〜2017/03
統合科学 Interdisciplinary Sciences 後期 全学共通科目 2016/04〜2017/03
分子遺伝学II Molecular Genetics II 前期 理学部 2017/04〜2018/03
感染防御学1 Infection and Host Defense 1 前期 薬学部 2017/04〜2018/03
感染防御学2 Infection and Host Defense 2 後期 薬学部 2017/04〜2018/03
統合科学 Interdisciplinary Sciences 後期 全学共通科目 2017/04〜2018/03
免疫学I Immunology I 後期 医学部(人間健康科学科) 2018/04〜2019/03
分子遺伝学II Molecular Genetics II 前期 理学部 2018/04〜2019/03
創薬生命科学概論 Introduction to Modern Life Sciences for Drug Discovery 前期不定 薬学研究科 2018/04〜2019/03
感染防御学1 Infection and Host Defense 1 前期 薬学部 2018/04〜2019/03
感染防御学2 Infection and Host Defense 2 後期 薬学部 2018/04〜2019/03
免疫学I Immunology I 後期 医学部(人間健康科学科) 2020/04〜2021/03
生化学 Biochemistry 前期集中 医学研究科 2020/04〜2021/03

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全学運営(役職等)
役職名 期間
動物実験委員会 委員 2012/10/01〜2014/09/30
京都大学動物実験委員会 副委員長 2016/10/01〜2018/09/30
医学図書館運営委員会 委員
国際教育委員会国際学生交流委員会アムジェン・スカラーズ・プログラム小委員会 委員 2017/12/21〜2019/03/31
組換えDNA実験安全委員会 委員 2020/04/01〜2020/09/30
部局運営(役職等)
役職名 期間
予算委員会 委員 2013/04/01〜2014/03/31
予算委員会 委員長 2014/04/01〜2015/03/31
広報委員会 委員 2013/04/01〜2014/03/31
広報委員会 委員長 2014/04/01〜2015/03/31
職員等配置検討委員会 委員 2014/04/01〜2015/03/31
兼業審査委員会 委員 2014/04/01〜2017/03/31
動物実験委員会 委員 2014/04/01〜2018/03/31
霊長類委員会 委員 2015/04/01〜2017/03/31
自己点検・評価委員会 委員 2015/04/01〜2017/03/31
予算委員会 2016/04/01〜2018/03/31
動物実験委員会 委員 2016/10/01〜
ウイルス動物実験専門委員会 委員 2016/10/01〜
霊長類動物実験専門委員会 委員 2016/10/01〜
兼業・利益相反審査員会 委員 2016/10/01〜
(旧ウイルス研)予算委員会 委員 2016/10/01〜
将来計画検討委員会 委員 2019/04/01〜2021/03/31
医学図書館運営委員会 委員 2019/04/01〜2021/03/31
医学研究科運営委員会 委員 〜2020/09/30
M.D.-Ph.D.コース運営委員会 委員
入学者選抜方法検討員 委員 2019/04/01〜2021/03/31
動物実験施設管理委員会 2020/04/01〜2022/03/31
教育研究支援基金委員会 2020/01/01〜2021/12/31

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学会活動:編集委員歴
学会名(日本語) 学会名(英語) ジャーナル名(日本語) ジャーナル名(英語) 役職名 期間
The American Association of Immunologists The American Association of Immunologists The Journal of Immunology The Journal of Immunology Associate Editor 2016/07/01〜