山根俊介

最終更新日時: 2019/06/17 20:01:28

氏名(漢字／フリガナ／アルファベット表記)

山根俊介／ヤマネシュンスケ／Yamane, Shunsuke

所属部署・職名(部局／所属／講座等／職名)

医学部附属病院／糖尿病・内分泌・栄養内科／助教

連絡先住所

種別	住所(日本語)	住所(英語)
職場	京都市左京区聖護院川原町５４	54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan

連絡先電話番号

種別	番号
職場	075-751-3560

所属学会(国内)

学会名(日本語)	学会名(英語)
日本糖尿病学会	Japan Diabetes Society
日本内科学会	The Japanese Society of Internal Medicine
日本内分泌学会	The Japan Endocrine Society

取得学位

学位名(日本語)	学位名(英語)	大学(日本語)	大学(英語)	取得区分
京都大学博士（医学）		京都大学		修了

プロフィール

(日本語)
大学病院の医師として診療に従事するとともに、糖尿病研究に従事している。教育に関しては、研究室の大学院生との共同研究の中で、実践的に研究能力を身につけさせることを目指している。また学術研究の成果を実臨床に応用できるよう日々邁進している。糖尿病協会主催のウォークラリー等の行事にも積極的に参加し、糖尿病患者、ご家族や糖尿病治療に携わっている人たちのコミュニケーションをとることにも努めている。
(英語)
I am working in Kyoto University Hospital as a clitician and conducting research on diabetes in our lab. As for education, one of my goals is to help graduate students acquire the practical skills needed to conduct joint research. Furthermore, I diligently take part in several events organized by JADEC (Japan Association for Diabetes Education and Care) to communicate with not only diabetic patients, but also their family members and paramedical staffs.

使用言語

言語名(japanese)	言語名(english)	コード
英語

researchmap URL

https://researchmap.jp/7000008971

研究テーマ

(日本語)
インクレチン分泌、作用に関する研究
(英語)
Mechanism of incretin secretion and incretin signaling

研究概要

(日本語)
経口栄養摂取に伴い腸管内分泌細胞から分泌され、膵β細胞からのインスリン分泌増強作用を有するペプチドホルモンをインクレチンといい、糖尿病治療薬としてすでに臨床応用されている。インクレチンとしてglucagon-like peptide-1 (GLP-1)およびgastric inhibitory polypeptide (GIP)が知られており、糖質や脂質の摂取により、腸管内分泌細胞であるK細胞からGIPの分泌が、L細胞からGLP-1の分泌が惹起される。これまでに開発されたインクレチン関連薬は、GLP-1の受容体作動薬およびインクレチンの分解酵素であるdipeptidyl peptidase-4（DPP-4）の阻害薬であり、いずれもインクレチンの分泌自体を増強させる機序は有していない。当教室の研究によりGIPシグナルは肥満状態における代償的インスリン分泌増加や、高脂肪食負荷による脂肪蓄積において重要な役割を果たしていることが確認されている。しかしGIPが糖質や脂質に反応して分泌されるメカニズムに関しては未だに不明な点が多い。また高脂肪食負荷後肥満状態のマウスでは通常食摂取マウスに比較してGIP分泌の亢進が認められるが、肥満状態におけるGIP分泌亢進の機序に関しても全く解明が進んでいない。このようにインクレチンの分泌機構・代謝状態の変化による分泌制御機構に関しては不明な点が多いが、その理由としてこれらを分泌するK細胞やL細胞の単離が困難であることが挙げられ、手法が模索されてきた。われわれはGFPをGIP遺伝子部位にノックインした遺伝子改変マウス(GIP-GFPノックインマウス)を作製し、このマウスの小腸上皮からGFP標識K細胞を単離・回収することに成功した。このマウスを用いて詳細なGIP分泌機構を解明することで、GIP分泌制御を介した肥満症の新たな治療法の開発を目指している。
(英語)
Incretins are defined as intestinal hormones released in response to nutrient ingestion, which potentiate the glucose-induced insulin secretion from pancreatic β-cells. The incretin effect is mainly caused by two peptide hormones, gastric inhibitory polypeptide (GIP), and glucagon-like peptide-1 (GLP-1). GIP is secreted by K cells from the upper small intestine, while GLP-1 is mainly produced in the enteroendocrine L cells located in the distal small intestine and colon. Both GIP and GLP-1 are rapidly degraded by the enzyme dipeptidyl-peptidase-4 (DPP-4) and two types of incretin-besed anti-diabetic drugs have been developed, DPP-4 inhibitors and GLP-1 receptor agonists resistant to the degradation by DPP-4. We have demonstrated that single fat ingestion stimulates GIP secretion from enteroendocrine K cells and chronic high-fat diet (HFD) loading enhances GIP secretion and induces obesity in mice in a GIP-dependent manner. However, the mechanisms of GIP secretion from K cells in response to fat ingestion and GIP hypersecretion in HFD-induced obesity are not well understood primarily due to difficulties in separating K-cells from other intestinal epithelial cells in vivo. In order to resolve this problem, we generated GIP-green fluorescent protein (GFP) knock-in (GIPgfp/+) mice, in which K cells are labeled by enhanced GFP. We generated GIP-green fluorescent protein knock-in (GIP (gfp/+)) mice, in which K cells are labeled by enhanced GIP-green fluorescent protein. Microarray analysis of isolated K cells from GIPgfp/+ mice enabled us to investigate the candidate molecules associated with GIP secretion. Further, detailed analyses of intracellular signaling of GIP secretion and synthesis in response to nutrient ingestion, regulation of GIP secretion could provide a novel therapeutic approach to prevent obesity, insulin resistance and subsequent type 2 diabetes.

研究分野（キーワード）

キーワード(日本語)	キーワード(英語)
インクレチン分泌	incretin secretion

論文

著者	著者(日本語)	著者(英語)	タイトル	タイトル(日本語)	タイトル(英語)	書誌情報等	書誌情報等(日本語)	書誌情報等(英語)	出版年月	査読の有無	記述言語	掲載種別	公開
Ikeguchi E, Harada N, Kanemaru Y, Sankoda A, Yamane S, Iwasaki K, Imajo M, Murata Y, Suzuki K, Joo E, Inagaki N	Ikeguchi E, Harada N, Kanemaru Y, Sankoda A, Yamane S, Iwasaki K, Imajo M, Murata Y, Suzuki K, Joo E, Inagaki N	Ikeguchi E, Harada N, Kanemaru Y, Sankoda A, Yamane S, Iwasaki K, Imajo M, Murata Y, Suzuki K, Joo E, Inagaki N	Transcriptional factor pancreatic duodenal homeobox-1 (Pdx1) is involved in age-related GIP hypersecretion in mice.	Transcriptional factor pancreatic duodenal homeobox-1 (Pdx1) is involved in age-related GIP hypersecretion in mice.	Transcriptional factor pancreatic duodenal homeobox-1 (Pdx1) is involved in age-related GIP hypersecretion in mice.	American journal of physiology. Gastrointestinal and liver physiology	American journal of physiology. Gastrointestinal and liver physiology	American journal of physiology. Gastrointestinal and liver physiology	2018/05	有			公開
Yamane S, Inagaki N	Yamane S, Inagaki N	Yamane S, Inagaki N	Regulation of glucagon-like peptide-1 sensitivity by gut microbiota dysbiosis.	Regulation of glucagon-like peptide-1 sensitivity by gut microbiota dysbiosis.	Regulation of glucagon-like peptide-1 sensitivity by gut microbiota dysbiosis.	Journal of diabetes investigation, 9, 2, 262-264	Journal of diabetes investigation, 9, 2, 262-264	Journal of diabetes investigation, 9, 2, 262-264	2018/03	有			公開
Mano F, Ikeda K, Joo E, Yamane S, Harada N, Inagaki N	Mano F, Ikeda K, Joo E, Yamane S, Harada N, Inagaki N	Mano F, Ikeda K, Joo E, Yamane S, Harada N, Inagaki N	Effects of three major amino acids found in Japanese broth on glucose metabolism and gastric emptying.	Effects of three major amino acids found in Japanese broth on glucose metabolism and gastric emptying.	Effects of three major amino acids found in Japanese broth on glucose metabolism and gastric emptying.	Nutrition (Burbank, Los Angeles County, Calif.), 46, 153-158.e1	Nutrition (Burbank, Los Angeles County, Calif.), 46, 153-158.e1	Nutrition (Burbank, Los Angeles County, Calif.), 46, 153-158.e1	2018/02	有			公開
Choi J, Kobayashi H, Okuda H, Harada KH, Takeda M, Fujimoto H, Yamane S, Tanaka D, Youssefian S, Inagaki N, Koizumi A	Choi J, Kobayashi H, Okuda H, Harada KH, Takeda M, Fujimoto H, Yamane S, Tanaka D, Youssefian S, Inagaki N, Koizumi A	Choi J, Kobayashi H, Okuda H, Harada KH, Takeda M, Fujimoto H, Yamane S, Tanaka D, Youssefian S, Inagaki N, Koizumi A	β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice.	β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice.	β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice.	PloS one, 13, 1, e0190863	PloS one, 13, 1, e0190863	PloS one, 13, 1, e0190863	2018	有			公開
山根俊介	山根俊介	Shimazu-Kuwahara S, Harada N, Yamane S, Joo E, Sankoda A, Kieffer TJ, Inagaki N.	Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice.	Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice.	Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice.	Mol Metab., 6, 3, 288-294	Mol Metab., 6, 3, 288-294	Mol Metab., 6, 3, 288-294	2017	有	英語	研究論文(学術雑誌)	公開
山根俊介	山根俊介	Joo E, Harada N, Yamane S, Fukushima T, Taura D, Iwasaki K, Sankoda A, Shibue K, Harada T, Suzuki K, Hamasaki A, Inagaki N.	Inhibition of gastric inhibitory polypeptide receptor signaling in adipose tissue reduces insulin resistance and hepatic steatosis in high fat diet-fed mice.	Inhibition of gastric inhibitory polypeptide receptor signaling in adipose tissue reduces insulin resistance and hepatic steatosis in high fat diet-fed mice.	Inhibition of gastric inhibitory polypeptide receptor signaling in adipose tissue reduces insulin resistance and hepatic steatosis in high fat diet-fed mice.	Diabetes., 66, 4, 868-879	Diabetes., 66, 4, 868-879	Diabetes., 66, 4, 868-879	2017	有	英語	研究論文(学術雑誌)	公開
山根俊介	山根俊介	Sankoda A, Harada N, Iwasaki K, Yamane S, Murata Y, Shibue K, Thewjitcharoen Y, Suzuki K, Harada T, Kanemaru Y, Shimazu-Kuwahara S, Hirasawa A, Inagaki N.	Long chain free fatty acid receptor GPR120 mediates oil-induced GIP secretion through CCK in male mice.	Long chain free fatty acid receptor GPR120 mediates oil-induced GIP secretion through CCK in male mice.	Long chain free fatty acid receptor GPR120 mediates oil-induced GIP secretion through CCK in male mice.	Endocrinology.	Endocrinology.	Endocrinology.	2017	有	英語	研究論文(学術雑誌)	公開
山根俊介	山根俊介	Suzuki K, Iwasaki K, Murata Y, Harada N, Yamane S, Hamasaki A, Shibue K, Joo E, Sankoda A, Fujiwara Y, Hayashi Y, Inagaki N.	Distribution and hormonal characterization of primary murine L-cells throughout the gastrointestinal tract.	Distribution and hormonal characterization of primary murine L-cells throughout the gastrointestinal tract.	Distribution and hormonal characterization of primary murine L-cells throughout the gastrointestinal tract.	J Diabetes Investig.	J Diabetes Investig.	J Diabetes Investig.	2017	有	英語	研究論文(学術雑誌)	公開
山根俊介	山根俊介	Shunsuke Yamane, Norio Harada, Nobuya Inagaki	Mechanisms of fat-induced gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide secretion from K cells.	Mechanisms of fat-induced gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide secretion from K cells.	Mechanisms of fat-induced gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide secretion from K cells.	J Diabetes Investig., 7, Suppl 1, 20-26	J Diabetes Investig., 7, Suppl 1, 20-26	J Diabetes Investig., 7, Suppl 1, 20-26	2016/04	有	英語		公開
山根俊介	山根俊介	Shunsuke Yamane, Nobuya Inagaki	Control of intestinal stem cell fate: A novel approach to treating diabetes.	Control of intestinal stem cell fate: A novel approach to treating diabetes.	Control of intestinal stem cell fate: A novel approach to treating diabetes.	J Diabetes Investig., 7, 2, 166-168	J Diabetes Investig., 7, 2, 166-168	J Diabetes Investig., 7, 2, 166-168	2016/03	有	英語		公開
Joo E, Muraoka A, Hamasaki A, Harada N, Yamane S, Kondo Y, Suzuki K, Nasteska D, Shibue K, Harada T, Iwasaki K, Tsuji H, Shide K, Inagaki N	Joo E, Muraoka A, Hamasaki A, Harada N, Yamane S, Kondo Y, Suzuki K, Nasteska D, Shibue K, Harada T, Iwasaki K, Tsuji H, Shide K, Inagaki N	Joo E, Muraoka A, Hamasaki A, Harada N, Yamane S, Kondo Y, Suzuki K, Nasteska D, Shibue K, Harada T, Iwasaki K, Tsuji H, Shide K, Inagaki N	Enteral supplementation with glutamine, fiber, and oligosaccharide modulates incretin and glucagon-like peptide-2 secretion.	Enteral supplementation with glutamine, fiber, and oligosaccharide modulates incretin and glucagon-like peptide-2 secretion.	Enteral supplementation with glutamine, fiber, and oligosaccharide modulates incretin and glucagon-like peptide-2 secretion.	Journal of diabetes investigation, 6, 3, 302-308	Journal of diabetes investigation, 6, 3, 302-308	Journal of diabetes investigation, 6, 3, 302-308	2015/05	有			公開
Yabe D, Kuroe A, Watanabe K, Iwasaki M, Hamasaki A, Hamamoto Y, Harada N, Yamane S, Lee S, Murotani K, Deacon CF, Holst JJ, Hirano T, Inagaki N, Kurose T, Seino Y	Yabe D, Kuroe A, Watanabe K, Iwasaki M, Hamasaki A, Hamamoto Y, Harada N, Yamane S, Lee S, Murotani K, Deacon CF, Holst JJ, Hirano T, Inagaki N, Kurose T, Seino Y	Yabe D, Kuroe A, Watanabe K, Iwasaki M, Hamasaki A, Hamamoto Y, Harada N, Yamane S, Lee S, Murotani K, Deacon CF, Holst JJ, Hirano T, Inagaki N, Kurose T, Seino Y	Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients.	Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients.	Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients.	Journal of diabetes and its complications, 29, 3, 413-421	Journal of diabetes and its complications, 29, 3, 413-421	Journal of diabetes and its complications, 29, 3, 413-421	2015/04	有			公開
Shibue K, Yamane S, Harada N, Hamasaki A, Suzuki K, Joo E, Iwasaki K, Nasteska D, Harada T, Hayashi Y, Adachi Y, Owada Y, Takayanagi R, Inagaki N	Shibue K, Yamane S, Harada N, Hamasaki A, Suzuki K, Joo E, Iwasaki K, Nasteska D, Harada T, Hayashi Y, Adachi Y, Owada Y, Takayanagi R, Inagaki N	Shibue K, Yamane S, Harada N, Hamasaki A, Suzuki K, Joo E, Iwasaki K, Nasteska D, Harada T, Hayashi Y, Adachi Y, Owada Y, Takayanagi R, Inagaki N	Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion.	Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion.	Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion.	American journal of physiology. Endocrinology and metabolism, 308, 7, E583-91	American journal of physiology. Endocrinology and metabolism, 308, 7, E583-91	American journal of physiology. Endocrinology and metabolism, 308, 7, E583-91	2015/04	有			公開
Iwasaki K, Harada N, Sasaki K, Yamane S, Iida K, Suzuki K, Hamasaki A, Nasteska D, Shibue K, Joo E, Harada T, Hashimoto T, Asakawa Y, Hirasawa A, Inagaki N	Iwasaki K, Harada N, Sasaki K, Yamane S, Iida K, Suzuki K, Hamasaki A, Nasteska D, Shibue K, Joo E, Harada T, Hashimoto T, Asakawa Y, Hirasawa A, Inagaki N	Iwasaki K, Harada N, Sasaki K, Yamane S, Iida K, Suzuki K, Hamasaki A, Nasteska D, Shibue K, Joo E, Harada T, Hashimoto T, Asakawa Y, Hirasawa A, Inagaki N	Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion.	Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion.	Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion.	Endocrinology, 156, 3, 837-846	Endocrinology, 156, 3, 837-846	Endocrinology, 156, 3, 837-846	2015/03	有			公開
S. Harashima; T. Fukushima; M. Sasaki; Y. Nishi; S. Fujimoto; M. Ogura; S. Yamane; D. Tanaka; N. Harada; A. Hamasaki; K. Nagashima; Y. Nakahigashi; Y. Seino; N. Inagaki	S. Harashima; T. Fukushima; M. Sasaki; Y. Nishi; S. Fujimoto; M. Ogura; S. Yamane; D. Tanaka; N. Harada; A. Hamasaki; K. Nagashima; Y. Nakahigashi; Y. Seino; N. Inagaki	S. Harashima; T. Fukushima; M. Sasaki; Y. Nishi; S. Fujimoto; M. Ogura; S. Yamane; D. Tanaka; N. Harada; A. Hamasaki; K. Nagashima; Y. Nakahigashi; Y. Seino; N. Inagaki	Self-monitoring of blood glucose (SMBG) improves glycemic control in oral hypoglycemic agent (OHA)-treated type 2 diabetes	Self-monitoring of blood glucose (SMBG) improves glycemic control in oral hypoglycemic agent (OHA)-treated type 2 diabetes	Self-monitoring of blood glucose (SMBG) improves glycemic control in oral hypoglycemic agent (OHA)-treated type 2 diabetes	Diabetes Technology and Therapeutics, 16, SUPPL. 1, S8	Diabetes Technology and Therapeutics, 16, SUPPL. 1, S8	Diabetes Technology and Therapeutics, 16, SUPPL. 1, S8	2014	有	英語		公開
S. Yamane; N. Inagaki	S. Yamane; N. Inagaki	S. Yamane; N. Inagaki	Long-term effect of dipeptidyl peptidase-4 inhibition on β-cell mass in an advanced-aged diet-induced obesity mouse model	Long-term effect of dipeptidyl peptidase-4 inhibition on β-cell mass in an advanced-aged diet-induced obesity mouse model	Long-term effect of dipeptidyl peptidase-4 inhibition on β-cell mass in an advanced-aged diet-induced obesity mouse model	Journal of Diabetes Investigation, 5, 2, 142-143	Journal of Diabetes Investigation, 5, 2, 142-143	Journal of Diabetes Investigation, 5, 2, 142-143	2014	有	英語		公開
E. Joo; S. Yamane; A. Hamasaki; N. Harada; T. Matsunaga; A. Muraoka; K. Suzuki; D. Nasteska; T. Fukushima; T. Hayashi; H. Tsuji; K. Shide; K. Tsuda; N. Inagaki	E. Joo; S. Yamane; A. Hamasaki; N. Harada; T. Matsunaga; A. Muraoka; K. Suzuki; D. Nasteska; T. Fukushima; T. Hayashi; H. Tsuji; K. Shide; K. Tsuda; N. Inagaki	E. Joo; S. Yamane; A. Hamasaki; N. Harada; T. Matsunaga; A. Muraoka; K. Suzuki; D. Nasteska; T. Fukushima; T. Hayashi; H. Tsuji; K. Shide; K. Tsuda; N. Inagaki	Enteral supplement enriched with glutamine, fiber, and oligosaccharide attenuates experimental colitis in mice	Enteral supplement enriched with glutamine, fiber, and oligosaccharide attenuates experimental colitis in mice	Enteral supplement enriched with glutamine, fiber, and oligosaccharide attenuates experimental colitis in mice	Nutrition, 29, 3, 549-555	Nutrition, 29, 3, 549-555	Nutrition, 29, 3, 549-555	2013/03	有	英語		公開
S.-I. Harashima; T. Fukushima; M. Sasaki; Y. Nishi; S. Fujimoto; M. Ogura; S. Yamane; D. Tanaka; N. Harada; A. Hamasaki; K. Nagashima; Y. Nakahigashi; Y. Seino; N. Inagaki	S.-I. Harashima; T. Fukushima; M. Sasaki; Y. Nishi; S. Fujimoto; M. Ogura; S. Yamane; D. Tanaka; N. Harada; A. Hamasaki; K. Nagashima; Y. Nakahigashi; Y. Seino; N. Inagaki	S.-I. Harashima; T. Fukushima; M. Sasaki; Y. Nishi; S. Fujimoto; M. Ogura; S. Yamane; D. Tanaka; N. Harada; A. Hamasaki; K. Nagashima; Y. Nakahigashi; Y. Seino; N. Inagaki	Self-monitoring of blood glucose (SMBG) improves glycaemic control in oral hypoglycaemic agent (OHA)-treated type 2 diabetes (SMBG-OHA study)	Self-monitoring of blood glucose (SMBG) improves glycaemic control in oral hypoglycaemic agent (OHA)-treated type 2 diabetes (SMBG-OHA study)	Self-monitoring of blood glucose (SMBG) improves glycaemic control in oral hypoglycaemic agent (OHA)-treated type 2 diabetes (SMBG-OHA study)	Diabetes/Metabolism Research and Reviews, 29, 1, 77-84	Diabetes/Metabolism Research and Reviews, 29, 1, 77-84	Diabetes/Metabolism Research and Reviews, 29, 1, 77-84	2013/01	有	英語		公開
K. Suzuki; N. Harada; S. Yamane; Y. Nakamura; K. Sasaki; D. Nasteska; E. Joo; K. Shibue; T. Harada; A. Hamasaki; K. Toyoda; K. Nagashima; N. Inagaki	K. Suzuki; N. Harada; S. Yamane; Y. Nakamura; K. Sasaki; D. Nasteska; E. Joo; K. Shibue; T. Harada; A. Hamasaki; K. Toyoda; K. Nagashima; N. Inagaki	K. Suzuki; N. Harada; S. Yamane; Y. Nakamura; K. Sasaki; D. Nasteska; E. Joo; K. Shibue; T. Harada; A. Hamasaki; K. Toyoda; K. Nagashima; N. Inagaki	Transcriptional regulatory factor X6 (RFX6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine k-cells and is involved in GIP hypersecretion in high fat diet-induced obesity	Transcriptional regulatory factor X6 (RFX6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine k-cells and is involved in GIP hypersecretion in high fat diet-induced obesity	Transcriptional regulatory factor X6 (RFX6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine k-cells and is involved in GIP hypersecretion in high fat diet-induced obesity	Journal of Biological Chemistry, 288, 3, 1929-1938	Journal of Biological Chemistry, 288, 3, 1929-1938	Journal of Biological Chemistry, 288, 3, 1929-1938	2013	有	英語		公開
S.-I. Harashima; D. Tanaka; S. Yamane; M. Ogura; Y. Fujita; Y. Murata; M. Seike; T. Koizumi; M. Aono; Y. Wang; N. Inagaki	S.-I. Harashima; D. Tanaka; S. Yamane; M. Ogura; Y. Fujita; Y. Murata; M. Seike; T. Koizumi; M. Aono; Y. Wang; N. Inagaki	S.-I. Harashima; D. Tanaka; S. Yamane; M. Ogura; Y. Fujita; Y. Murata; M. Seike; T. Koizumi; M. Aono; Y. Wang; N. Inagaki	Efficacy and safety of switching from basal insulin to sitagliptin in Japanese type 2 diabetes patients	Efficacy and safety of switching from basal insulin to sitagliptin in Japanese type 2 diabetes patients	Efficacy and safety of switching from basal insulin to sitagliptin in Japanese type 2 diabetes patients	Hormone and Metabolic Research, 45, 3, 231-238	Hormone and Metabolic Research, 45, 3, 231-238	Hormone and Metabolic Research, 45, 3, 231-238	2013	有	英語		公開
Y. Kondo; N. Harada; T. Sozu; A. Hamasaki; S. Yamane; A. Muraoka; T. Harada; K. Shibue; D. Nasteska; E. Joo; K. Sasaki; N. Inagaki	Y. Kondo; N. Harada; T. Sozu; A. Hamasaki; S. Yamane; A. Muraoka; T. Harada; K. Shibue; D. Nasteska; E. Joo; K. Sasaki; N. Inagaki	Y. Kondo; N. Harada; T. Sozu; A. Hamasaki; S. Yamane; A. Muraoka; T. Harada; K. Shibue; D. Nasteska; E. Joo; K. Sasaki; N. Inagaki	A hospital-based cross-sectional study to develop an estimation formula for 2-h post-challenge plasma glucose for screening impaired glucose tolerance	A hospital-based cross-sectional study to develop an estimation formula for 2-h post-challenge plasma glucose for screening impaired glucose tolerance	A hospital-based cross-sectional study to develop an estimation formula for 2-h post-challenge plasma glucose for screening impaired glucose tolerance	Diabetes Research and Clinical Practice, 101, 2, 218-225	Diabetes Research and Clinical Practice, 101, 2, 218-225	Diabetes Research and Clinical Practice, 101, 2, 218-225	2013	有	英語		公開
S. Yamane; N. Harada; A. Hamasaki; A. Muraoka; E. Joo; K. Suzuki; D. Nasteska; D. Tanaka; M. Ogura; S.-I. Harashima; N. Inagaki	S. Yamane; N. Harada; A. Hamasaki; A. Muraoka; E. Joo; K. Suzuki; D. Nasteska; D. Tanaka; M. Ogura; S.-I. Harashima; N. Inagaki	S. Yamane; N. Harada; A. Hamasaki; A. Muraoka; E. Joo; K. Suzuki; D. Nasteska; D. Tanaka; M. Ogura; S.-I. Harashima; N. Inagaki	Effects of glucose and meal ingestion on incretin secretion in Japanese subjects with normal glucose tolerance	Effects of glucose and meal ingestion on incretin secretion in Japanese subjects with normal glucose tolerance	Effects of glucose and meal ingestion on incretin secretion in Japanese subjects with normal glucose tolerance	Journal of Diabetes Investigation, 3, 1, 80-85	Journal of Diabetes Investigation, 3, 1, 80-85	Journal of Diabetes Investigation, 3, 1, 80-85	2012	有	英語		公開
S. Yamane; N. Inagaki	S. Yamane; N. Inagaki	S. Yamane; N. Inagaki	[Clinical biomarkers for diabetes mellitus].	[Clinical biomarkers for diabetes mellitus].	[Clinical biomarkers for diabetes mellitus].	Nihon rinsho. Japanese journal of clinical medicine, 70, 5, 846-851	Nihon rinsho. Japanese journal of clinical medicine, 70, 5, 846-851	Nihon rinsho. Japanese journal of clinical medicine, 70, 5, 846-851	2012	有	英語		公開
E. Ogawa; M. Hosokawa; N. Harada; S. Yamane; A. Hamasaki; K. Toyoda; S. Fujimoto; Y. Fujita; K. Fukuda; K. Tsukiyama; Y. Yamada; Y. Seino; N. Inagaki	E. Ogawa; M. Hosokawa; N. Harada; S. Yamane; A. Hamasaki; K. Toyoda; S. Fujimoto; Y. Fujita; K. Fukuda; K. Tsukiyama; Y. Yamada; Y. Seino; N. Inagaki	E. Ogawa; M. Hosokawa; N. Harada; S. Yamane; A. Hamasaki; K. Toyoda; S. Fujimoto; Y. Fujita; K. Fukuda; K. Tsukiyama; Y. Yamada; Y. Seino; N. Inagaki	The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice	The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice	The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice	Biochemical and Biophysical Research Communications, 404, 1, 115-120	Biochemical and Biophysical Research Communications, 404, 1, 115-120	Biochemical and Biophysical Research Communications, 404, 1, 115-120	2011/01/07	有	英語		公開
N. Harada; A. Hamasaki; S. Yamane; A. Muraoka; E. Joo; K. Fujita; N. Inagaki	N. Harada; A. Hamasaki; S. Yamane; A. Muraoka; E. Joo; K. Fujita; N. Inagaki	N. Harada; A. Hamasaki; S. Yamane; A. Muraoka; E. Joo; K. Fujita; N. Inagaki	Plasma gastric inhibitory polypeptide and glucagon-like peptide-1 levels after glucose loading are associated with different factors in Japanese subjects	Plasma gastric inhibitory polypeptide and glucagon-like peptide-1 levels after glucose loading are associated with different factors in Japanese subjects	Plasma gastric inhibitory polypeptide and glucagon-like peptide-1 levels after glucose loading are associated with different factors in Japanese subjects	Journal of Diabetes Investigation, 2, 3, 193-199	Journal of Diabetes Investigation, 2, 3, 193-199	Journal of Diabetes Investigation, 2, 3, 193-199	2011	有	英語		公開
S. Yamane; Y. Hamamoto; S.-I. Harashima; N. Harada; A. Hamasaki; K. Toyoda; K. Fujita; E. Joo; Y. Seino; N. Inagaki	S. Yamane; Y. Hamamoto; S.-I. Harashima; N. Harada; A. Hamasaki; K. Toyoda; K. Fujita; E. Joo; Y. Seino; N. Inagaki	S. Yamane; Y. Hamamoto; S.-I. Harashima; N. Harada; A. Hamasaki; K. Toyoda; K. Fujita; E. Joo; Y. Seino; N. Inagaki	GLP-1 receptor agonist attenuates endoplasmic reticulum stress-mediated β-cell damage in Akita mice	GLP-1 receptor agonist attenuates endoplasmic reticulum stress-mediated β-cell damage in Akita mice	GLP-1 receptor agonist attenuates endoplasmic reticulum stress-mediated β-cell damage in Akita mice	Journal of Diabetes Investigation, 2, 2, 104-110	Journal of Diabetes Investigation, 2, 2, 104-110	Journal of Diabetes Investigation, 2, 2, 104-110	2011	有	英語		公開
T. Uonaga; K. Toyoda; T. Okitsu; X. Zhuang; S. Yamane; S. Uemoto; N. Inagaki	T. Uonaga; K. Toyoda; T. Okitsu; X. Zhuang; S. Yamane; S. Uemoto; N. Inagaki	T. Uonaga; K. Toyoda; T. Okitsu; X. Zhuang; S. Yamane; S. Uemoto; N. Inagaki	FGF-21 enhances islet engraftment in mouse syngeneic islet transplantation model	FGF-21 enhances islet engraftment in mouse syngeneic islet transplantation model	FGF-21 enhances islet engraftment in mouse syngeneic islet transplantation model	Islets, 2, 4, 247-251	Islets, 2, 4, 247-251	Islets, 2, 4, 247-251	2010/07	有	英語		公開
Y. Kawasaki; S. Harashima; M. Sasaki; E. Mukai; Y. Nakamura; N. Harada; K. Toyoda; A. Hamasaki; S. Yamane; C. Yamada; Y. Yamada; Y. Seino; N. Inagaki	Y. Kawasaki; S. Harashima; M. Sasaki; E. Mukai; Y. Nakamura; N. Harada; K. Toyoda; A. Hamasaki; S. Yamane; C. Yamada; Y. Yamada; Y. Seino; N. Inagaki	Y. Kawasaki; S. Harashima; M. Sasaki; E. Mukai; Y. Nakamura; N. Harada; K. Toyoda; A. Hamasaki; S. Yamane; C. Yamada; Y. Yamada; Y. Seino; N. Inagaki	Exendin-4 protects pancreatic beta cells from the cytotoxic effect of rapamycin by inhibiting JNK and p38 phosphorylation	Exendin-4 protects pancreatic beta cells from the cytotoxic effect of rapamycin by inhibiting JNK and p38 phosphorylation	Exendin-4 protects pancreatic beta cells from the cytotoxic effect of rapamycin by inhibiting JNK and p38 phosphorylation	Hormone and Metabolic Research, 42, 5, 311-317	Hormone and Metabolic Research, 42, 5, 311-317	Hormone and Metabolic Research, 42, 5, 311-317	2010/05	有	英語		公開
X. Liu; N. Harada; S. Yamane; L. Kitajima; S. Uchida; A. Hamasaki; E. Mukai; K. Toyoda; C. Yamada; Y. Yamada; Y. Seino; N. Inagaki	X. Liu; N. Harada; S. Yamane; L. Kitajima; S. Uchida; A. Hamasaki; E. Mukai; K. Toyoda; C. Yamada; Y. Yamada; Y. Seino; N. Inagaki	X. Liu; N. Harada; S. Yamane; L. Kitajima; S. Uchida; A. Hamasaki; E. Mukai; K. Toyoda; C. Yamada; Y. Yamada; Y. Seino; N. Inagaki	Effects of long-term dipeptidyl peptidase-IV inhibition on body composition and glucose tolerance in high fat diet-fed mice	Effects of long-term dipeptidyl peptidase-IV inhibition on body composition and glucose tolerance in high fat diet-fed mice	Effects of long-term dipeptidyl peptidase-IV inhibition on body composition and glucose tolerance in high fat diet-fed mice	Life Sciences, 84, 25-26, 876-881	Life Sciences, 84, 25-26, 876-881	Life Sciences, 84, 25-26, 876-881	2009/06/19	有	英語		公開
K. Toyoda; T. Okitsu; S. Yamane; T. Uonaga; X. Liu; N. Harada; S. Uemoto; Y. Seino; N. Inagaki	K. Toyoda; T. Okitsu; S. Yamane; T. Uonaga; X. Liu; N. Harada; S. Uemoto; Y. Seino; N. Inagaki	K. Toyoda; T. Okitsu; S. Yamane; T. Uonaga; X. Liu; N. Harada; S. Uemoto; Y. Seino; N. Inagaki	GLP-1 receptor signaling protects pancreatic beta cells in intraportal islet transplant by inhibiting apoptosis	GLP-1 receptor signaling protects pancreatic beta cells in intraportal islet transplant by inhibiting apoptosis	GLP-1 receptor signaling protects pancreatic beta cells in intraportal islet transplant by inhibiting apoptosis	Biochemical and Biophysical Research Communications, 367, 4, 793-798	Biochemical and Biophysical Research Communications, 367, 4, 793-798	Biochemical and Biophysical Research Communications, 367, 4, 793-798	2008/03/21	有	英語		公開
C. Yamada; Y. Yamada; K. Tsukiyama; K. Yamada; S. Yamane; N. Harada; K. Miyawaki; Y. Seino; N. Inagaki	C. Yamada; Y. Yamada; K. Tsukiyama; K. Yamada; S. Yamane; N. Harada; K. Miyawaki; Y. Seino; N. Inagaki	C. Yamada; Y. Yamada; K. Tsukiyama; K. Yamada; S. Yamane; N. Harada; K. Miyawaki; Y. Seino; N. Inagaki	Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes	Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes	Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes	Biochemical and Biophysical Research Communications, 364, 1, 175-180	Biochemical and Biophysical Research Communications, 364, 1, 175-180	Biochemical and Biophysical Research Communications, 364, 1, 175-180	2007/12/07	有	英語		公開
A. Hamasaki; T. Taniguchi; S. Yamane; M. Ida; M. Okamoto; Y. Yamada; N. Inagaki; Y. Seino	A. Hamasaki; T. Taniguchi; S. Yamane; M. Ida; M. Okamoto; Y. Yamada; N. Inagaki; Y. Seino	A. Hamasaki; T. Taniguchi; S. Yamane; M. Ida; M. Okamoto; Y. Yamada; N. Inagaki; Y. Seino	A case of fulminant type 1 diabetes associated with painless thyroiditis [4]	A case of fulminant type 1 diabetes associated with painless thyroiditis [4]	A case of fulminant type 1 diabetes associated with painless thyroiditis [4]	Diabetes Care, 29, 4, 946-947	Diabetes Care, 29, 4, 946-947	Diabetes Care, 29, 4, 946-947	2006	有	英語		公開
Y. Hamamoto; M. Hosokawa; A. Hamasaki; H. Nishi; S. Yamane; Y. Yamada; Y. Seino	Y. Hamamoto; M. Hosokawa; A. Hamasaki; H. Nishi; S. Yamane; Y. Yamada; Y. Seino	Y. Hamamoto; M. Hosokawa; A. Hamasaki; H. Nishi; S. Yamane; Y. Yamada; Y. Seino	A case of pyomyositis of the left thigh in type 2 diabetes mellitus associated with diabetic ketoacidosis	A case of pyomyositis of the left thigh in type 2 diabetes mellitus associated with diabetic ketoacidosis	A case of pyomyositis of the left thigh in type 2 diabetes mellitus associated with diabetic ketoacidosis	Journal of the Japan Diabetes Society, 46, 5, 387-392	Journal of the Japan Diabetes Society, 46, 5, 387-392	Journal of the Japan Diabetes Society, 46, 5, 387-392	2003	有	英語		公開
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外部資金：競争的資金・科学研究費補助金

種別	代表/分担	テーマ(日本語)	期間
日本学術振興会平成26年度学術研究助成基金助成金（若手研究B）	代表	転写因子Rfx6のGIP産生K細胞における機能の解析	2014〜2016/03/31
若手研究（Ｂ）	代表	転写因子Rfx6のGIP産生K細胞における機能の解析（平成26年度分）	2014/04/01〜2015/03/31
若手研究（Ｂ）	代表	転写因子Rfx6のGIP産生K細胞における機能の解析（平成27年度分）	2015/04/01〜2016/03/31
日本学術振興会平成28年度学術研究助成基金助成金（基盤研究C)	代表	脂肪酸結合タンパク5 (FABP5)によるGIP分泌制御機構の解明	2016/06/24〜
基盤研究(C)	代表	脂肪酸結合タンパク5 (FABP5) によるGIP分泌制御機構の解明（平成28年度分）	2016/04/01〜2017/03/31
基盤研究(C)	代表	脂肪酸結合タンパク5 (FABP5) によるGIP分泌制御機構の解明（平成29年度分）	2017/04/01〜2018/03/31
基盤研究(C)	代表	脂肪酸結合タンパク5 (FABP5) によるGIP分泌制御機構の解明（平成30年度分）	2018/04/01〜2019/03/31
日本学術振興会平成31年度学術研究助成基金助成金（基盤研究C）	代表	炭酸脱水酵素8(Car8)によるGLP-1分泌制御機構の解明	〜

外部資金：競争的資金・科学研究費補助金以外

制度名	代表者名	研究課題(日本語)	研究課題(英語)	期間
2015年度万有生命科学振興国際交流財団研究助成「生活習慣病領域」	山根俊介	脂肪酸結合タンパクを介したGIP分泌機序の解明		2015/09/09〜2017/10/31

担当科目

講義名(日本語)	講義名(英語)	開講期	学部/研究科	年度
フィジカルアセスメント	Physical Assessment	前期	医学研究科（人間健康科学系専攻）	2019/04〜2020/03

山根 俊介

山根俊介