杉山 弘

最終更新日時:2016/07/27 18:07:10

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氏名(漢字/フリガナ/アルファベット表記)
杉山 弘/スギヤマ ヒロシ/Hiroshi Sugiyama
所属部署・職名(部局/所属/講座等/職名)
理学研究科/化学専攻生物化学講座/教授
学部兼担
部局 所属 講座等 職名
理学部
学内兼務
部局 所属 講座等 職名
物質-細胞統合システム拠点 連携主任研究者
連絡先住所
種別 住所(日本語) 住所(英語)
職場 〒606-8502 京都市左京区北白川追分町 Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto, 606-8502
連絡先電話番号
種別 番号
職場 075-753-4002
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
工学修士 京都大学
工学博士 京都大学
職歴
期間 組織名(日本語) 組織名(英語) 職名(日本語) 職名(英語)
研究テーマ
(日本語)
DNAを中心としたケミカルバイオロジー研究
(英語)
Chemical Biology of DNA
研究概要
(日本語)
杉山グループでは核酸の生物有機化学を行っている。合成化学と分子生物学の手法を用いて、核酸の分子認識、反応性と構造について研究している。核酸を物質としてこのように一般的にそして基本的に研究しているグループは他にない。グループでは以下の領域での研究を具体的に行っている。DNAの塩基のアルキル化、水素引き抜き、電子移動によるDNAの修飾についての分子機構の解明。抗癌性抗生物質の作用機構の理解に基づいた配列特異的なアルキル化剤の開発。DNAの局所構造の解析法の開発。細胞の分化や病気の治療を目指した人工遺伝子スイッチの開発を長期的な目標としている。
(英語)
Professor Sugiyama's research interests involve the bioorganic chemistry of nucleic acids. Using the tools of synthetic physical organic chemistry and molecular biology, the Sugiyama group is defining the chemical principles underlying the recognition, reactivity and structure of nucleic acids. There are no other research groups on such a general and fundamental aspect of nucleic acids as a substance.The group utilizes a chemical approach in following areas: Molecular mechanism of DNA modification by DNA base alkylation, hydrogen abstraction and charge transfer. Design of highly efficient sequence-specific DNA acting agents based on understanding of the action mechanism of antitumor antibiotics. Design of unnatural nucleic acid for understanding of nucleic acid structure and function. Development of a method probing DNA local conformation in vivo. The long-range goal is creation of artificial genetic switches for targeted cell differentiation and treatment of many diseases.
研究分野(科研費分類コード)
科研費分類コード
情報学基礎
論文 > 論文
(文系研究者の一般的な論文集への寄稿や単行本の分担執筆などは「著書等」を参照してください)
著者名 タイトル 書誌情報等 年月 査読の有無 言語
Ohtsuki S, Matsuzaki N, Mohri K, Endo M, Emura T, Hidaka K, Sugiyama H, Takahashi Y, Ishiyama K, Kadowaki N, Takakura Y, Nishikawa M Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulatory Nucleic Acids to Immune Cells. Nucleic acid therapeutics,25,5,245-253 2015/10
Endo M, Takeuchi Y, Suzuki Y, Emura T, Hidaka K, Wang F, Willner I, Sugiyama H Single-Molecule Visualization of the Activity of a Zn(2+) -Dependent DNAzyme. Angewandte Chemie (International ed. in English),54,36,10550-10554 2015/09
Suzuki Y, Endo M, Sugiyama H Studying RNAP-promoter interactions using atomic force microscopy. Methods (San Diego, Calif.),86,4-9 2015/09
Endo M, Xing X, Zhou X, Emura T, Hidaka K, Tuesuwan B, Sugiyama H Single-Molecule Manipulation of the Duplex Formation and Dissociation at the G-Quadruplex/i-Motif Site in the DNA Nanostructure. ACS nano 2015/09
Nishida Y, Ohtsuki S, Araie Y, Umeki Y, Endo M, Emura T, Hidaka K, Sugiyama H, Takahashi Y, Takakura Y, Nishikawa M Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells. Nanomedicine : nanotechnology, biology, and medicine 2015/09
Yang Y, Goetzfried MA, Hidaka K, You M, Tan W, Sugiyama H, Endo M Direct Visualization of Walking Motions of Photocontrolled Nanomachine on the DNA Nanostructure. Nano letters 2015/09
Saha A, Hashiya F, Kizaki S, Asamitsu S, Hashiya K, Bando T, Sugiyama H A novel detection technique of polyamide binding sites by photo-induced electron transfer in (Br)U substituted DNA. Chemical communications (Cambridge, England),51,77,14485-14488 2015/09
Tashiro R, Iwamoto M, Morinaga H, Emura T, Hidaka K, Endo M, Sugiyama H Linking two DNA duplexes with a rigid linker for DNA nanotechnology. Nucleic acids research,43,14,6692-6700 2015/08
Suzuki Y, Endo M, Sugiyama H Lipid-bilayer-assisted two-dimensional self-assembly of DNA origami nanostructures. Nature communications,6,8052 2015/08
Taylor RD, Chandran A, Kashiwazaki G, Hashiya K, Bando T, Nagase H, Sugiyama H Selective Targeting of the KRAS Codon 12 Mutation Sequence by Pyrrole-Imidazole Polyamide seco-CBI Conjugates. Chemistry (Weinheim an der Bergstrasse, Germany) 2015/08
Patel S, Chueng SD, Yin PT, Dardir K, Song Z, Pasquale N, Kwan K, Sugiyama H, Lee KB Induction of Stem-Cell-Derived Functional Neurons by NanoScript-Based Gene Repression. Angewandte Chemie (International ed. in English) 2015/08
Endo M, Sugiyama H DNA nanotechnology: Measuring chloride in live cells. Nature nanotechnology,10,7,569-570 2015/07
Goto N, Bazar G, Kovacs Z, Kunisada M, Morita H, Kizaki S, Sugiyama H, Tsenkova R, Nishigori C Detection of UV-induced cyclobutane pyrimidine dimers by near-infrared spectroscopy and aquaphotomics. Scientific reports,5,11808 2015/07
Patel S, Yin PT, Sugiyama H, Lee KB Inducing Stem Cell Myogenesis Using NanoScript. ACS nano,9,7,6909-6917 2015/07
Han L, Pandian GN, Chandran A, Sato S, Taniguchi J, Kashiwazaki G, Sawatani Y, Hashiya K, Bando T, Xu Y, Qian X, Sugiyama H A Synthetic DNA-Binding Domain Guides Distinct Chromatin-Modifying Small Molecules to Activate an Identical Gene Network. Angewandte Chemie (International ed. in English),54,30,8700-8703 2015/07
Syed J, Chandran A, Pandian GN, Taniguchi J, Sato S, Hashiya K, Kashiwazaki G, Bando T, Sugiyama H A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts. Chembiochem : a European journal of chemical biology,16,10,1497-1501 2015/07
Rajendran A, Endo M, Hidaka K, Teulade-Fichou MP, Mergny JL, Sugiyama H Small molecule binding to a G-hairpin and a G-triplex: a new insight into anticancer drug design targeting G-rich regions. Chemical communications (Cambridge, England),51,44,9181-9184 2015/06
Li Y, Sugiyama H Photoreactivity of the linker region of two consecutive G-quadruplexes formed by human telomeric DNA. Chemical communications (Cambridge, England),51,42,8861-8864 2015/05
Hiraoka K, Inoue T, Taylor RD, Watanabe T, Koshikawa N, Yoda H, Shinohara K, Takatori A, Sugimoto H, Maru Y, Denda T, Fujiwara K, Balmain A, Ozaki T, Bando T, Sugiyama H, Nagase H Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate. Nature communications,6,6706 2015/04
Suzuki Y, Endo M, Sugiyama H Mimicking membrane-related biological events by DNA origami nanotechnology. ACS nano,9,4,3418-3420 2015/04
Patel S, Pongkulapa T, Yin PT, Pandian GN, Rathnam C, Bando T, Vaijayanthi T, Sugiyama H, Lee KB Integrating epigenetic modulators into NanoScript for enhanced chondrogenesis of stem cells. Journal of the American Chemical Society,137,14,4598-4601 2015/04
Mohri K, Kusuki E, Ohtsuki S, Takahashi N, Endo M, Hidaka K, Sugiyama H, Takahashi Y, Takakura Y, Nishikawa M Self-assembling DNA dendrimer for effective delivery of immunostimulatory CpG DNA to immune cells. Biomacromolecules,16,4,1095-1101 2015/04
Guo C, Kawamoto Y, Asamitsu S, Sawatani Y, Hashiya K, Bando T, Sugiyama H Rational design of specific binding hairpin Py-Im polyamides targeting human telomere sequences. Bioorganic & medicinal chemistry,23,4,855-860 2015/02
Anandhakumar C, Kizaki S, Bando T, Pandian GN, Sugiyama H Advancing small-molecule-based chemical biology with next-generation sequencing technologies. Chembiochem : a European journal of chemical biology,16,1,20-38 2015/01
Shibata T, Suzuki Y, Sugiyama H, Endo M, Saito H Folding RNA-Protein Complex into Designed Nanostructures. Methods in molecular biology (Clifton, N.J.),1316,169-179 2015
Igarashi J, Fukuda N, Inoue T, Nakai S, Saito K, Fujiwara K, Matsuda H, Ueno T, Matsumoto Y, Watanabe T, Nagase H, Bando T, Sugiyama H, Itoh T, Soma M Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model. PloS one,10,5,e0125295 2015
Umemura A, Oeda T, Yamamoto K, Tomita S, Kohsaka M, Park K, Sugiyama H, Sawada H Baseline Plasma C-Reactive Protein Concentrations and Motor Prognosis in Parkinson Disease. PloS one,10,8,e0136722 2015
Hashiya F, Saha A, Kizaki S, Li Y, Sugiyama H Locating the uracil-5-yl radical formed upon photoirradiation of 5-bromouracil-substituted DNA. Nucleic acids research,42,22,13469-13473 2014/12
Anandhakumar C, Li Y, Kizaki S, Pandian GN, Hashiya K, Bando T, Sugiyama H Next-generation sequencing studies guide the design of pyrrole-imidazole polyamides with improved binding specificity by the addition of β-alanine. Chembiochem : a European journal of chemical biology,15,18,2647-2651 2014/12
Pandian GN, Sato S, Anandhakumar C, Taniguchi J, Takashima K, Syed J, Han L, Saha A, Bando T, Nagase H, Sugiyama H Identification of a small molecule that turns ON the pluripotency gene circuitry in human fibroblasts. ACS chemical biology,9,12,2729-2736 2014/12
Endo M, Takeuchi Y, Emura T, Hidaka K, Sugiyama H Preparation of chemically modified RNA origami nanostructures. Chemistry (Weinheim an der Bergstrasse, Germany),20,47,15330-15333 2014/11
Ghimire C, Park S, Iida K, Yangyuoru P, Otomo H, Yu Z, Nagasawa K, Sugiyama H, Mao H Direct quantification of loop interaction and π-π stacking for G-quadruplex stability at the submolecular level. Journal of the American Chemical Society,136,44,15537-15544 2014/11
Takenaka T, Endo M, Suzuki Y, Yang Y, Emura T, Hidaka K, Kato T, Miyata T, Namba K, Sugiyama H Photoresponsive DNA nanocapsule having an open/close system for capture and release of nanomaterials. Chemistry (Weinheim an der Bergstrasse, Germany),20,46,14951-14954 2014/11
Syed J, Pandian GN, Sato S, Taniguchi J, Chandran A, Hashiya K, Bando T, Sugiyama H Targeted suppression of EVI1 oncogene expression by sequence-specific pyrrole-imidazole polyamide. Chemistry & biology,21,10,1370-1380 2014/10
Saha A, Pandian GN, Sato S, Taniguchi J, Kawamoto Y, Hashiya K, Bando T, Sugiyama H Chemical modification of a synthetic small molecule boosts its biological efficacy against pluripotency genes in mouse fibroblasts. ChemMedChem,9,10,2374-2380 2014/10
Patel S, Jung D, Yin PT, Carlton P, Yamamoto M, Bando T, Sugiyama H, Lee KB NanoScript: a nanoparticle-based artificial transcription factor for effective gene regulation. ACS nano,8,9,8959-8967 2014/09
Asamitsu S, Kawamoto Y, Hashiya F, Hashiya K, Yamamoto M, Kizaki S, Bando T, Sugiyama H Sequence-specific DNA alkylation and transcriptional inhibition by long-chain hairpin pyrrole-imidazole polyamide-chlorambucil conjugates targeting CAG/CTG trinucleotide repeats. Bioorganic & medicinal chemistry,22,17,4646-4657 2014/09
Taylor RD, Kawamoto Y, Hashiya K, Bando T, Sugiyama H Sequence-specific DNA alkylation by tandem Py-Im polyamide conjugates. Chemistry, an Asian journal,9,9,2527-2533 2014/09
Osada E, Suzuki Y, Hidaka K, Ohno H, Sugiyama H, Endo M, Saito H Engineering RNA-protein complexes with different shapes for imaging and therapeutic applications. ACS nano,8,8,8130-8140 2014/08
Hirata A, Nokihara K, Kawamoto Y, Bando T, Sasaki A, Ide S, Maeshima K, Kasama T, Sugiyama H Structural evaluation of tandem hairpin pyrrole-imidazole polyamides recognizing human telomeres. Journal of the American Chemical Society,136,32,11546-11554 2014/08
Rajendran A, Endo M, Hidaka K, Shimada N, Maruyama A, Sugiyama H A lock-and-key mechanism for the controllable fabrication of DNA origami structures. Chemical communications (Cambridge, England),50,63,8743-8746 2014/08
Koirala D, Shrestha P, Emura T, Hidaka K, Mandal S, Endo M, Sugiyama H, Mao H Single-molecule mechanochemical sensing using DNA origami nanostructures. Angewandte Chemie (International ed. in English),53,31,8137-8141 2014/07
Endo M, Yamamoto S, Emura T, Hidaka K, Morone N, Heuser JE, Sugiyama H Helical DNA origami tubular structures with various sizes and arrangements. Angewandte Chemie (International ed. in English),53,29,7484-7490 2014/07
Suzuki Y, Endo M, Cañas C, Ayora S, Alonso JC, Sugiyama H, Takeyasu K Direct analysis of Holliday junction resolving enzyme in a DNA origami nanostructure. Nucleic acids research,42,11,7421-7428 2014/06
Endo M, Sugiyama H Single-molecule imaging of dynamic motions of biomolecules in DNA origami nanostructures using high-speed atomic force microscopy. Accounts of chemical research,47,6,1645-1653 2014/06
Yamamoto S, De D, Hidaka K, Kim KK, Endo M, Sugiyama H Single molecule visualization and characterization of Sox2-Pax6 complex formation on a regulatory DNA element using a DNA origami frame. Nano letters,14,5,2286-2292 2014/05
Yang Y, Endo M, Suzuki Y, Hidaka K, Sugiyama H Direct observation of the dual-switching behaviors corresponding to the state transition in a DNA nanoframe. Chemical communications (Cambridge, England),50,32,4211-4213 2014/04
Rajendran A, Endo M, Hidaka K, Sugiyama H Direct and single-molecule visualization of the solution-state structures of G-hairpin and G-triplex intermediates. Angewandte Chemie (International ed. in English),53,16,4107-4112 2014/04
Pandian GN, Taniguchi J, Sugiyama H Cellular reprogramming for pancreatic β-cell regeneration: clinical potential of small molecule control. Clinical and translational medicine,3,1,6 2014/03
M. Yamamoto; T. Bando; Y. Kawamoto; R.D. Taylor; K. Hashiya; H. Sugiyama Specific alkylation of human telomere repeat sequences by a tandem-hairpin motif of pyrrole-imidazole polyamides with indole-seco-CBI Bioconjugate Chemistry,25,3,552-559 2014/03 英語
Y. Suzuki; M. Endo; Y. Yang; H. Sugiyama Dynamic assembly/disassembly processes of photoresponsive DNA origami nanostructures directly visualized on a lipid membrane surface Journal of the American Chemical Society,136,5,1714-1717 2014/02 英語
S. Park; H. Otomo; L. Zheng; H. Sugiyama Highly emissive deoxyguanosine analogue capable of direct visualization of B-Z transition Chemical Communications,50,13,1573-1575 2014/02 英語
G.N. Pandian; J. Taniguchi; S. Junetha; S. Sato; L. Han; A. Saha; C. Anandhakumar; T. Bando; H. Nagase; T. Vaijayanthi; R.D. Taylor; H. Sugiyama Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts Scientific Reports,4,3843 2014/01 英語
Taylor RD, Asamitsu S, Takenaka T, Yamamoto M, Hashiya K, Kawamoto Y, Bando T, Nagase H, Sugiyama H Sequence-specific DNA alkylation targeting for Kras codon 13 mutation by pyrrole-imidazole polyamide seco-CBI conjugates. Chemistry (Weinheim an der Bergstrasse, Germany),20,5,1310-1317 2014/01
Sannohe Y, Kizaki S, Kanesato S, Fujiwara A, Li Y, Morinaga H, Tashiro R, Sugiyama H Controlling electron rebound within four-base π-stacks in Z-DNA by changing the sugar moiety from deoxy- to ribonucleotide. Chemistry (Weinheim an der Bergstrasse, Germany),20,5,1223-1225 2014/01
M. Yamamoto; T. Bando; H. Morinaga; Y. Kawamoto; K. Hashiya; H. Sugiyama Sequence-specific DNA recognition by cyclic pyrrole-imidazole cysteine-derived polyamide dimers Chemistry - A European Journal,20,3,752-759 2014/01 英語
Y. Suzuki; M. Endo; Y. Katsuda; K. Ou; K. Hidaka; H. Sugiyama DNA origami based visualization system for studying site-specific recombination events Journal of the American Chemical Society,136,1,211-218 2014/01 英語
A. Rajendran; M. Endo; H. Sugiyama State-of-the-art high-speed atomic force microscopy for investigation of single-molecular dynamics of proteins Chemical Reviews,114,2,1493-1520 2014/01 英語
S. Kizaki; H. Sugiyama CGmCGCG is a versatile substrate with which to evaluate Tet protein activity Organic and Biomolecular Chemistry,12,1,104-107 2014/01 英語
Chen FY, Park S, Otomo H, Sakashita S, Sugiyama H Investigation of B-Z transitions with DNA oligonucleotides containing 8-methylguanine. Artificial DNA, PNA & XNA,5,1,e28226 2014
A. Rajendran; M. Endo; K. Hidaka; P.L.T. Tran; J.-L. Mergny; R.J. Gorelick; H. Sugiyama HIV-1 nucleocapsid proteins as molecular chaperones for tetramolecular antiparallel g-quadruplex formation Journal of the American Chemical Society,135,49,18575-18585 2013/12 英語
M. Endo; M. Inoue; Y. Suzuki; C. Masui; H. Morinaga; K. Hidaka; H. Sugiyama Regulation of B-Z conformational transition and complex formation with a z-form binding protein by introduction of constraint to double-stranded DNA by using a DNA nanoscaffold Chemistry - A European Journal,19,50,16887-16890 2013/12 英語
W. Kameshima; T. Ishizuka; M. Minoshima; M. Yamamoto; H. Sugiyama; Y. Xu; M. Komiyama Conjugation of peptide nucleic acid with a pyrrole/imidazole polyamide to specifically recognize and cleave DNA Angewandte Chemie - International Edition,52,51,13681-13684 2013/12 英語
L. Han; G.N. Pandian; S. Junetha; S. Sato; C. Anandhakumar; J. Taniguchi; A. Saha; T. Bando; H. Nagase; H. Sugiyama A synthetic small molecule for targeted transcriptional activation of germ cell genes in a human somatic cell Angewandte Chemie - International Edition,52,50,13410-13413 2013/12 英語
Y.-L. Wu; G.N. Pandian; Y.-P. Ding; W. Zhang; Y. Tanaka; H. Sugiyama Clinical grade iPS cells: Need for versatile small molecules and optimal cell sources Chemistry and Biology,20,11,1311-1322 2013/11 英語
Y. Kawamoto; T. Bando; F. Kamada; Y. Li; K. Hashiya; K. Maeshima; H. Sugiyama Development of a new method for synthesis of tandem hairpin pyrrole-imidazole polyamide probes targeting human telomeres Journal of the American Chemical Society,135,44,16468-16477 2013/11 英語
S. Masuda; J. Wu; T. Hishida; G.N. Pandian; H. Sugiyama; J.C. Izpisua Belmonte Chemically induced pluripotent stem cells (CiPSCs): A transgene-free approach Journal of Molecular Cell Biology,5,5,354-355 2013/10 英語
A. Rajendran; M. Endo; K. Hidaka; P. Lan Thao Tran; J.-L. Mergny; H. Sugiyama Controlling the stoichiometry and strand polarity of a tetramolecular G-quadruplex structure by using a DNA origami frame Nucleic Acids Research,41,18,8738-8747 2013/10 英語
Y.-W. Han; G. Kashiwazaki; H. Morinaga; T. Matsumoto; K. Hashiya; T. Bando; Y. Harada; H. Sugiyama Effect of single pyrrole replacement with β-alanine on DNA binding affinity and sequence specificity of hairpin pyrrole/imidazole polyamides targeting 5′-GCGC-3′ Bioorganic and Medicinal Chemistry,21,17,5436-5441 2013/09 英語
L.A. Yatsunyk; O. Piétrement; D. Albrecht; P.L.T. Tran; D. Renčiuk; H. Sugiyama; J.-M. Arbona; J.-P. Aimé; J.-L. Mergny Guided assembly of tetramolecular G-quadruplexes ACS Nano,7,7,5701-5710 2013/07 英語
A. Saha; G.N. Pandian; S. Sato; J. Taniguchi; K. Hashiya; T. Bando; H. Sugiyama Synthesis and biological evaluation of a targeted DNA-binding transcriptional activator with HDAC8 inhibitory activity Bioorganic and Medicinal Chemistry,21,14,4201-4209 2013/07 英語
M. Kunisada; T. Masaki; R. Ono; H. Morinaga; E. Nakano; F. Yogianti; K. Okunishi; H. Sugiyama; C. Nishigori Hydrochlorothiazide enhances UVA-induced DNA damage Photochemistry and Photobiology,89,3,649-654 2013/05 英語
M. Endo; S. Yamamoto; K. Tatsumi; T. Emura; K. Hidaka; H. Sugiyama RNA-templated DNA origami structures Chemical Communications,49,28,2879-2881 2013/04 英語
H. Morinaga; T. Takenaka; F. Hashiya; S. Kizaki; K. Hashiya; T. Bando; H. Sugiyama Sequence-specific electron injection into DNA from an intermolecular electron donor Nucleic Acids Research,41,8,4724-4728 2013/04 英語
D. Koirala; C. Ghimire; C. Bohrer; Y. Sannohe; H. Sugiyama; H. Mao Long-loop G-quadruplexes are misfolded population minorities with fast transition kinetics in human telomeric sequences Journal of the American Chemical Society,135,6,2235-2241 2013/02 英語
T. Vaijayanthi; T. Bando; K. Hashiya; G.N. Pandian; H. Sugiyama Design of a new fluorescent probe: Pyrrole/imidazole hairpin polyamides with pyrene conjugation at their γ-turn Bioorganic and Medicinal Chemistry,21,4,852-855 2013/02 英語
A. Rajendran; M. Endo; K. Hidaka; H. Sugiyama Direct and real-time observation of rotary movement of a DNA nanomechanical device Journal of the American Chemical Society,135,3,1117-1123 2013/01 英語
H. Morinaga; S. Kizaki; T. Takenaka; S. Kanesato; Y. Sannohe; R. Tashiro; H. Sugiyama Photoreactivities of 5-Bromouracil-containing RNAs Bioorganic and Medicinal Chemistry,21,2,466-469 2013/01 英語
T. Miyahara; H. Nakatsuji; H. Sugiyama Helical structure and circular dichroism spectra of DNA: A theoretical study Journal of Physical Chemistry A,117,1,42-55 2013/01 英語
A. Rajendran; M. Endo; K. Hidaka; H. Sugiyama Control of the two-dimensional crystallization of DNA origami with various loop arrangements Chemical Communications,49,7,686-688 2013/01 英語
J. Liang; Y.-L. Wu; B.-J. Chen; W. Zhang; Y. Tanaka; H. Sugiyama The C-Kit receptor-mediated signal transduction and tumor-related diseases International Journal of Biological Sciences,9,5,435-443 2013 英語
A. Iguchi; N. Fukuda; T. Takahashi; T. Watanabe; H. Matsuda; H. Nagase; T. Bando; H. Sugiyama; K. Shimizu RNA binding properties of novel gene silencing pyrrole-imidazole polyamides Biological and Pharmaceutical Bulletin,36,7,1152-1158 2013 英語
Y. Yang; M. Endo; K. Hidaka; H. Sugiyama Photo-controllable DNA origami nanostructures assembling into predesigned multiorientational patterns Journal of the American Chemical Society,134,51,20645-20653 2012/12 英語
Y.-W. Han; T. Matsumoto; H. Yokota; G. Kashiwazaki; H. Morinaga; K. Hashiya; T. Bando; Y. Harada; H. Sugiyama Binding of hairpin pyrrole and imidazole polyamides to DNA: Relationship between torsion angle and association rate constants Nucleic Acids Research,40,22,11510-11517 2012/12 英語
G.N. Pandian; H. Sugiyama Strategies to modulate heritable epigenetic defects in cellular machinery: Lessons from nature Pharmaceuticals,6,1,1-24 2012/12 英語
S. Park; H. Sugiyama DNA as a chiral scaffold for asymmetric synthesis Molecules,17,11,12792-12803 2012/10 英語
T. Vaijayanthi; T. Bando; G.N. Pandian; H. Sugiyama Progress and Prospects of Pyrrole-Imidazole Polyamide-Fluorophore Conjugates as Sequence-Selective DNA Probes ChemBioChem,13,15,2170-2185 2012/10 英語
S. Park; K. Ikehata; R. Watabe; Y. Hidaka; A. Rajendran; H. Sugiyama Deciphering DNA-based asymmetric catalysis through intramolecular Friedel-Crafts alkylations Chemical Communications,48,84,10398-10400 2012/10 英語
M. Endo; Y. Yang; Y. Suzuki; K. Hidaka; H. Sugiyama Single-molecule visualization of the hybridization and dissociation of photoresponsive oligonucleotides and their reversible switching behavior in a DNA nanostructure Angewandte Chemie - International Edition,51,42,10518-10522 2012/10 英語
M. Endo; K. Tatsumi; K. Terushima; Y. Katsuda; K. Hidaka; Y. Harada; H. Sugiyama Direct visualization of the movement of a single T7 RNA polymerase and transcription on a DNA nanostructure Angewandte Chemie - International Edition,51,35,8778-8782 2012/08 英語
T. Takagaki; T. Bando; H. Sugiyama Synthesis of pyrrole-imidazole polyamide seco -1-chloromethyl-5-hydroxy-1, 2-dihydro-3 H -benz[ e ]indole conjugates with a vinyl linker recognizing a 7 bp DNA sequence Journal of the American Chemical Society,134,31,13074-13081 2012/08 英語
G.N. Pandian; Y. Nakano; S. Sato; H. Morinaga; T. Bando; H. Nagase; H. Sugiyama A synthetic small molecule for rapid induction of multiple pluripotency genes in mouse embryonic fibroblasts Scientific Reports,2,544 2012/07/30 英語
K. Mohri; M. Nishikawa; N. Takahashi; T. Shiomi; N. Matsuoka; K. Ogawa; M. Endo; K. Hidaka; H. Sugiyama; Y. Takahashi; Y. Takakura Design and development of nanosized DNA assemblies in polypod-like structures as efficient vehicles for immunostimulatory cpg motifs to immune cells ACS Nano,6,7,5931-5940 2012/07 英語
H.-F. Zhang; Y.-L. Wu; S.-K. Jiang; P. Wang; H. Sugiyama; X.-L. Chen; W. Zhang; Y.-J. Ji; C.-X. Guo Recognition by Nonaromatic and Stereochemical Subunit-Containing Polyamides of the Four Watson-Crick Base Pairs in the DNA Minor Groove ChemBioChem,13,9,1366-1374 2012/06 英語
G.N. Pandian; H. Sugiyama Programmable genetic switches to control transcriptional machinery of pluripotency Biotechnology Journal,7,6,798-809 2012/06 英語
G.N. Pandian; A. Ohtsuki; T. Bando; S. Sato; K. Hashiya; H. Sugiyama Development of programmable small DNA-binding molecules with epigenetic activity for induction of core pluripotency genes Bioorganic and Medicinal Chemistry,20,8,2656-2660 2012/04 英語
A. Rajendran; M. Endo; H. Sugiyama DNA origami: synthesis and self-assembly. Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.],Chapter 12,SUPPL. 48,Unit 12.9.1-18 2012/03 英語
Y. Sannohe; H. Sugiyama Single strand DNA catenane synthesis using the formation of G-quadruplex structure Bioorganic and Medicinal Chemistry,20,6,2030-2034 2012/03 英語
T. Yoshidome; M. Endo; G. Kashiwazaki; K. Hidaka; T. Bando; H. Sugiyama Sequence-selective single-molecule alkylation with a pyrrole-imidazole polyamide visualized in a DNA nanoscaffold Journal of the American Chemical Society,134,10,4654-4660 2012/03 英語
G. Kashiwazaki; T. Bando; T. Yoshidome; S. Masui; T. Takagaki; K. Hashiya; G.N. Pandian; J. Yasuoka; K. Akiyoshi; H. Sugiyama Synthesis and biological properties of highly sequence-specific-alkylating N-methylpyrrole- N -methylimidazole polyamide conjugates Journal of Medicinal Chemistry,55,5,2057-2066 2012/03 英語
E. Nakata; F.F. Liew; C. Uwatoko; S. Kiyonaka; Y. Mori; Y. Katsuda; M. Endo; H. Sugiyama; T. Morii Zinc-finger proteins for site-specific protein positioning on DNA-origami structures Angewandte Chemie - International Edition,51,10,2421-2424 2012/03 英語
M. Endo; R. Miyazaki; T. Emura; K. Hidaka; H. Sugiyama Transcription regulation system mediated by mechanical operation of a DNA nanostructure Journal of the American Chemical Society,134,6,2852-2855 2012/02 英語
D. Koirala; T. Mashimo; Y. Sannohe; Z. Yu; H. Mao; H. Sugiyama Intramolecular folding in three tandem guanine repeats of human telomeric DNA Chemical Communications,48,14,2006-2008 2012/02 英語
S.F.J. Wickham; J. Bath; Y. Katsuda; M. Endo; K. Hidaka; H. Sugiyama; A.J. Turberfield A DNA-based molecular motor that can navigate a network of tracks Nature Nanotechnology,7,3,169-173 2012/01 英語
N. Mulholland; Y. Xu; H. Sugiyama; K. Zhao SWI/SNF-mediated chromatin remodeling induces Z-DNA formation on a nucleosome Cell and Bioscience,2,1,3 2012/01 英語
A. Rajendran; M. Endo; H. Sugiyama Single-molecule analysis using DNA origami Angewandte Chemie - International Edition,51,4,874-890 2012/01 英語
W. Zhang; S.-K. Jiang; Y.-L. Wu; C.-X. Guo; H.-F. Zhang; H. Sugiyama; X.-L. Chen Discrimination between T/A and A/T Base Pairs of Pyrrole-Imidazole Polyamides Substituted with Chiral β-Hydroxy-γ-Aminobutyric Acid/β-Alanine Pairs ChemBioChem,13,1,47-50 2012/01 英語
A. Rajendran; M. Endo; H. Sugiyama Structural and functional analysis of proteins by high-speed atomic force microscopy Advances in Protein Chemistry and Structural Biology,87,5-55 2012 英語
G.N. Pandian; K.-I. Shinohara; A. Ohtsuki; Y. Nakano; M. Masafumi; T. Bando; H. Nagase; Y. Yamada; A. Watanabe; N. Terada; S. Sato; H. Morinaga; H. Sugiyama Synthetic small molecules for epigenetic activation of pluripotency genes in mouse embryonic fibroblasts ChemBioChem,12,18,2822-2828 2011/12 英語
A. Yasuda; K. Noguchi; M. Minoshima; G. Kashiwazaki; T. Kanda; K. Katayama; J. Mitsuhashi; T. Bando; H. Sugiyama; Y. Sugimoto DNA ligand designed to antagonize EBNA1 represses Epstein-Barr virus-induced immortalization Cancer Science,102,12,2221-2230 2011/12 英語
H. Morinaga; T. Bando; T. Takagaki; M. Yamamoto; K. Hashiya Cysteine cyclic pyrrole-imidazole polyamide for sequence-specific recognition in the DNA minor groove Journal of the American Chemical Society,133,46,18924-18930 2011/11 英語
T. Takagaki; T. Bando; M. Kitano; K. Hashiya; G. Kashiwazaki; H. Sugiyama Evaluation of PI polyamide conjugates with eight-base pair recognition and improvement of the aqueous solubility by PEGylation Bioorganic and Medicinal Chemistry,19,19,5896-5902 2011/10 英語
M. Endo; Y. Yang; T. Emura; K. Hidaka; H. Sugiyama Programmed placement of gold nanoparticles onto a slit-type DNA origami scaffold Chemical Communications,47,38,10743-10745 2011/10 英語
A. Rajendran; M. Endo; Y. Katsuda; K. Hidaka; H. Sugiyama Photo-cross-linking-assisted thermal stability of DNA origami structures and its application for higher-temperature self-assembly Journal of the American Chemical Society,133,37,14488-14491 2011/09 英語
D. Koirala; S. Dhakal; B. Ashbridge; Y. Sannohe; R. Rodriguez; H. Sugiyama; S. Balasubramanian; H. Mao A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands Nature Chemistry,3,10,782-787 2011/08 英語
M. Endo; H. Sugiyama Recent progress in DNA origami technology. Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.],Chapter 12,SUPPL. 45,Unit12.8 2011/06 英語
M. Endo; K. Hidaka; H. Sugiyama Direct AFM observation of an opening event of a DNA cuboid constructed via a prism structure Organic and Biomolecular Chemistry,9,7,2075-2077 2011/04 英語
S.F.J. Wickham; M. Endo; Y. Katsuda; K. Hidaka; J. Bath; H. Sugiyama; A.J. Turberfield Direct observation of stepwise movement of a synthetic molecular transporter Nature Nanotechnology,6,3,166-169 2011/03 英語
M. Endo; T. Sugita; A. Rajendran; Y. Katsuda; T. Emura; K. Hidaka; H. Sugiyama Two-dimensional DNA origami assemblies using a four-way connector Chemical Communications,47,11,3213-3215 2011/03 英語
S. Park; T. Bando; K.-I. Shinohara; S. Nishijima; H. Sugiyama Photocontrollable sequence-specific DNA alkylation by a pyrrole-imidazole polyamide seco-CBI conjugate Bioconjugate Chemistry,22,2,120-124 2011/02 英語
A. Rajendran; M. Endo; Y. Katsuda; K. Hidaka; H. Sugiyama Programmed two-dimensional self-assembly of multiple DNA origami jigsaw pieces ACS Nano,5,1,665-671 2011/01 英語
H. Matsuda; N. Fukuda; T. Ueno; M. Katakawa; X. Wang; T. Watanabe; S.-I. Matsui; T. Aoyama; K. Saito; T. Bando; Y. Matsumoto; H. Nagase; K. Matsumoto; H. Sugiyama Transcriptional inhibition of progressive renal disease by gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-Β1 promoter Kidney International,79,1,46-56 2011/01 英語
M. Endo; H. Sugiyama DNA origami-based construction of meso-scale multi-dimensional architects and expression of the functionality in the designed DNA nanospace Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry,69,12,1352-1362 2011 日本語
M. Endo; Y. Katsuda; K. Hidaka; H. Sugiyama A versatile DNA nanochip for direct analysis of DNA base-excision repair Angewandte Chemie - International Edition,49,49,9412-9416 2010/12 英語
Y. Sannohe; M. Endo; Y. Katsuda; K. Hidaka; H. Sugiyama Visualization of dynamic conformational switching of the G-quadruplex in a DNA nanostructure Journal of the American Chemical Society,132,46,16311-16313 2010/11 英語
T. Mashimo; H. Yagi; Y. Sannohe; A. Rajendran; H. Sugiyama Folding pathways of human telomeric type-1 and type-2 G-Quadruplex structures Journal of the American Chemical Society,132,42,14910-14918 2010/10 英語
R. Tashiro; A. Ohtsuki; H. Sugiyama The distance between donor and acceptor affects the proportion of C1′ and C2′ oxidation products of DNA in a <sup>Br</sup>U-containing excess electron transfer system Journal of the American Chemical Society,132,41,14361-14363 2010/10 英語
M. Hori; S.-I. Yonekura; T. Nohmi; P. Gruz; H. Sugiyama; S. Yonei; Q.-M. Zhang-Akiyama Error-prone translesion DNA synthesis by Escherichia coli DNA polymerase IV (DinB) on templates containing 1,2-dihydro-2-oxoadenine Journal of Nucleic Acids,2010,807579 2010/09 英語
H. Tanaka; Y. Tanaka; M. Minoshima; S. Yamaguchi; S. Fuse; T. Doi; S. Kawauchi; H. Sugiyama; T. Takahashi Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity Chemical Communications,46,32,5942-5944 2010/08 英語
S. Park; H. Sugiyama DNA-based hybrid catalysts for asymmetric organic synthesis Angewandte Chemie - International Edition,49,23,3870-3878 2010/05 英語
M. Endo; T. Sugita; Y. Katsuda; K. Hidaka; H. Sugiyama Programmed-assembly system using DNA jigsaw pieces Chemistry - A European Journal,16,18,5362-5368 2010/05 英語
G. Kashiwazaki; T. Bando; K.-i. Shinohara; M. Minoshima; H. Kumamoto; S. Nishijima; H. Sugiyama Alkylation of a human telomere sequence by heterotrimeric chlorambucil PI polyamide conjugates Bioorganic and Medicinal Chemistry,18,8,2887-2893 2010/04 英語
Y. Sannohe; H. Sugiyama Overview of formation of G-quadruplex structures Current Protocols in Nucleic Acid Chemistry,Chapter 17,SUPPL. 40,Unit 17.2.1-17 2010/03 英語
K.-I. Shinohara; Y. Sannohe; S. Kaieda; K.-I. Tanaka; H. Osuga; H. Tahara; Y. Xu; T. Kawase; T. Bando; H. Sugiyama A chiral wedge molecule inhibits telomerase activity Journal of the American Chemical Society,132,11,3778-3782 2010/03 英語
X. Wang; H. Nagase; T. Watanabe; H. Nobusue; T. Suzuki; Y. Asami; Y. Shinojima; H. Kawashima; K. Takagi; R. Mishra; J. Igarashi; M. Kimura; T. Takayama; N. Fukuda; H. Sugiyama Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrrole-imidazole polyamide Cancer Science,101,3,759-766 2010/03 英語
K.-I. Shinohara; T. Bando; H. Sugiyama Anticancer activities of alkylating pyrrole-imidazole polyamides with specific sequence recognition Anti-Cancer Drugs,21,3,228-242 2010/03 英語
M. Minoshima; T. Bando; K.-i. Shinohara; G. Kashiwazaki; S. Nishijima; H. Sugiyama Comparative analysis of DNA alkylation by conjugates between pyrrole-imidazole hairpin polyamides and chlorambucil or seco-CBI Bioorganic and Medicinal Chemistry,18,3,1236-1243 2010/02/01 英語
M. Endo; Y. Katsuda; K. Hidaka; H. Sugiyama Regulation of DNA methylation using different tensions of double strands constructed in a defined DNA nanostructure Journal of the American Chemical Society,132,5,1592-1597 2010/02 英語
S. Nishijima; K.-i. Shinohara; T. Bando; M. Minoshima; G. Kashiwazaki; H. Sugiyama Cell permeability of Py-Im-polyamide-fluorescein conjugates: Influence of molecular size and Py/Im content Bioorganic and Medicinal Chemistry,18,2,978-983 2010/01 英語
M. Minoshima; J.C. Chou; S. Lefebvre; T. Bando; K.-i. Shinohara; J.M. Gottesfeld; H. Sugiyama Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes Bioorganic and Medicinal Chemistry,18,1,168-174 2010/01 英語
照島功祐,遠藤政幸,勝田陽介,日高久美,杉山弘 RNA ポリメラーゼのDNA ナノ構造上 での1分子観測 日本化学会第90 春季年会, 大阪,2010年3 月26 日-3 月 29 日 2010 日本語
M. Endo; K. Hidaka; T. Kato; K. Namba; H. Sugiyama DNA prism structures constructed by folding of multiple rectangular arms Journal of the American Chemical Society,131,43,15570-15571 2009/11 英語
K. Kino; K. Sugasawa; T. Mizuno; T. Bando; H. Sugiyama; M. Akita; H. Miyazawa; F. Hanaoka Eukaryotic DNA polymerases α, β and ε incorporate guanine opposite 2,2,4-triamino-5(2H)-oxazolone ChemBioChem,10,16,2613-2616 2009/11 英語
M. Endo; H. Sugiyama Chemical approaches to DNA nanotechnology ChemBioChem,10,15,2420-2443 2009/10 英語
M. Webba da Silva; M. Trajkovski; Y. Sannohe; N.M. Hessari; H. Sugiyama; J. Plavec Design of a G-quadruplex topology through glycosidic bond angles Angewandte Chemie - International Edition,48,48,9167-9170 2009 英語
E.-H. Yao; N. Fukuda; T. Ueno; H. Matsuda; H. Nagase; Y. Matsumoto; H. Sugiyama; K. Matsumoto A pyrrole-imidazole polyamide targeting transforming growth factor-β1 inhibits restenosis and preserves endothelialization in the injured artery Cardiovascular Research,81,4,797-804 2009 日本語
R. Tashiro; H. Sugiyama Photochemistry of 5-Bromouracil- Or 5-Iodouracil-containing DNA: Probe for DNA structure and charge transfer along DNA Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry,67,12,1261-1273 2009 日本語
Y. Xu; H. Sato; Y. Sannohe; K.-I. Shinohara; H. Sugiyama Stable lariat formation based on a G-quadruplex scaffold Journal of the American Chemical Society,130,49,16470-16471 2008/12 英語
T. Bando; H. Sugiyama The chemical biology that controls DNA function and structure Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry,63,10,1016-1027 2005 日本語
H. Iida; H. Sugiyama Recognition of DNA sequences by pyrrole-imidazole polyamide: Rational drug design in the post-genome era Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry,58,10,975-987 2000 日本語
H. Sugiyama Mechanism of oxidative DNA strand scission Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,40,10,1444-1456 1995 日本語
A. Rajendran; M. Endo; K. Hidaka; P.L.T. Tran; M.-P. Teulade-Fichou; J.-L. Mergny; H. Sugiyama G-quadruplex-binding ligand-induced DNA synapsis inside a DNA origami frame RSC Advances,4,12,6346-6355 2014 英語
Y.-W. Han; Y. Tsunaka; H. Yokota; T. Matsumoto; G. Kashiwazaki; H. Morinaga; K. Hashiya; T. Bando; H. Sugiyama; Y. Harada Construction and characterization of Cy3- or Cy5-conjugated hairpin pyrrole-imidazole polyamides binding to DNA in the nucleosome Biomaterials Science,2,3,297-307 2014 英語
M. Endo; Y. Yang; H. Sugiyama DNA origami technology for biomaterials applications Biomaterials Science,1,4,347-360 2013 英語
S. Park; K. Ikehata; H. Sugiyama Solid-supported DNA for asymmetric synthesis: A stepping-stone toward practical applications Biomaterials Science,1,10,1034-1036 2013 英語
M. Endo; H. Sugiyama DNA nanomachines that move on the DNA origami structures Kobunshi,62,3,129-131 2013 英語
Y.-L. Wu; J. Liang; W. Zhang; Y. Tanaka; H. Sugiyama Immunotherapies: The blockade of inhibitory signals International Journal of Biological Sciences,8,10,1420-1430 2012 英語
Endo M., Yang Y., Suzuki Y., Hidaka K., Sugiyama H. Single-molecule observation of hybridization and dissociation of photoresponsive oligonucleotides and their reversible mechanical behavior in the designed DNA nanostructure. Angew.Chem. Int. Ed. 51, 10518-10522 2012 英語
Y. Okabe; H. Sugiyama; T. Inayoshi Lightweight actuator structure with SMA honeycomb core and CFRP skins Journal of Mechanical Design, Transactions of the ASME,133,1 2011 英語
Matsuda, H.; Fukuda, N.; Ueno, T.; Katakawa, M.; Wang, X.; Watanabe, T.; Matsui, S.; Aoyama, T.; Saito, K.; Bando, T.; Matsumoto, Y.; Nagase, H.; Matsumoto, K.; Sugiyama, H. Transcriptional Inhibition of Progressive Renal Disease by the Gene Silencing Pyrrole-Imidazole polyamide Targeted to the TGF-β1Promoter. Kidney Int., 2011, 79, 46-56. 2011 英語
A. Ohtsuki; M.T. Kimura; M. Minoshima; T. Suzuki; M. Ikeda; T. Bando; H. Nagase; K.-i. Shinohara; H. Sugiyama Synthesis and properties of PI polyamide-SAHA conjugate Tetrahedron Letters,50,52,7288-7292 2009/12/30 英語
H. Morinaga; S.-I. Yonekura; N. Nakamura; H. Sugiyama; S. Yonei; Q.-M. Zhang-Akiyama Purification and characterization of Caenorhabditis elegans NTH, a homolog of human endonuclease III: Essential role of N-terminal region DNA Repair,8,7,844-851 2009/07/04 英語
T. Suzuki; Y. Asami; T. Takahashi; X. Wang; T. Watanabe; T. Bando; H. Sugiyama; N. Fukuda; H. Nagase Development of a molecule-recognized promoter DNA sequence for inhibition of HER2 expression Journal of Antibiotics,62,6,339-341 2009/06 英語
T. Nagashima; T. Aoyama; T. Yokoe; A. Fukasawa; N. Fukuda; T. Ueno; H. Sugiyama; H. Nagase; Y. Matsumoto Pharmacokinetic modeling and prediction of plasma pyrrole-imidazole polyamide concentration in rats using simultaneous urinary and biliary excretion data Biological and Pharmaceutical Bulletin,32,5,921-927 2009/05 英語
T. Nagashima; T. Aoyama; A. Fukasawa; S. Watabe; N. Fukuda; T. Ueno; H. Sugiyama; H. Nagase; Y. Matsumoto Determination of pyrrole-imidazole polyamide in rat plasma by liquid chromatography-tandem mass spectrometry Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences,877,11-12,1070-1076 2009/04/15 英語
Q.-M. Zhang-Akiyama; H. Morinaga; M. Kikuchi; S.-I. Yonekura; H. Sugiyama; K. Yamamoto; S. Yonei KsgA, a 16S rRNA adenine methyltransferase, has a novel DNA glycosylase/ AP lyase activity to prevent mutations in Escherichia coli Nucleic Acids Research,37,7,2116-2125 2009/04 英語
Y. Sannohe; K. Sato; A. Matsugami; K.-i. Shinohara; T. Mashimo; M. Katahira; H. Sugiyama The orientation of the ends of G-quadruplex structures investigated using end-extended oligonucleotides Bioorganic and Medicinal Chemistry,17,5,1870-1875 2009/03/01 英語
A. Fukasawa; T. Aoyama; T. Nagashima; N. Fukuda; T. Ueno; H. Sugiyama; H. Nagase; Y. Matsumoto Pharmacokinetics of pyrrole-imidazole polyamides after intravenous administration in rat Biopharmaceutics and Drug Disposition,30,2,81-89 2009/03 英語
T. Ueno; N. Fukuda; A. Tsunemi; E.-H. Yao; H. Matsuda; K. Tahira; T. Matsumoto; K. Matsumoto; Y. Matsumoto; H. Nagase; H. Sugiyama; T. Sawamura A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function Journal of Hypertension,27,3,508-516 2009/03 英語
G. Kashiwazaki; T. Bando; K.-i. Shinohara; M. Minoshima; S. Nishijima; H. Sugiyama Cooperative alkylation of double-strand human telomere repeat sequences by PI polyamides with 11-base-pair recognition based on a heterotrimeric design Bioorganic and Medicinal Chemistry,17,3,1393-1397 2009/02/01 英語
T. Suzuki; Y. Asami; T. Takahashi; X. Wang; T. Watanabe; T. Bando; H. Sugiyama; N. Fukuda; H. Nagase Erratum: Development of a molecule-recognized promoter DNA sequence for inhibition of HER2 expression (The Journal of Antibiotics (2009) 62 (345) doi:10.1038/ja.2009.42)) Journal of Antibiotics,62,6,345- 2009 英語
K. Okamoto; Y. Sannohe; T. Mashimo; H. Sugiyama; M. Terazima G-quadruplex structures of human telomere DNA examined by single molecule FRET and BrG-substitution Bioorganic and Medicinal Chemistry,16,14,6873-6879 2008/07/15 英語
R. Tashiro; K. Nakamura; H. Sugiyama Photoreaction of iodouracil in DNA duplex; C-I bond is cleaved via two different pathways \\'homolysis and heterolysis\\' Tetrahedron Letters,49,3,428-431 2008 英語
S. Sasaki; T. Bando; M. Minoshima; K.-I. Shinohara; H. Sugiyama Sequence-specific alkylation by Y-shaped and tandem hairpin pyrrole-imidazole polyamides Chemistry - A European Journal,14,3,864-870 2008 英語
T. Bando; M. Minoshima; G. Kashiwazaki; K.-i. Shinohara; S. Sasaki; J. Fujimoto; A. Ohtsuki; M. Murakami; S. Nakazono; H. Sugiyama Requirement of β-alanine components in sequence-specific DNA alkylation by pyrrole-imidazole conjugates with seven-base pair recognition Bioorganic and Medicinal Chemistry,16,5,2286-2291 2008 英語
M. Minoshima; T. Bando; S. Sasaki; J. Fujimoto; H. Sugiyama Pyrrole-imidazole hairpin polyamides with high affinity at 5′-CGCG-3′ DNA sequence; influence of cytosine methylation on binding Nucleic Acids Research,36,9,2889-2894 2008 英語
J. Fujimoto; T. Bando; M. Minoshima; S. Uchida; M. Iwasaki; K.-i. Shinohara; H. Sugiyama Detection of triplet repeat sequences in the double-stranded DNA using pyrene-functionalized pyrrole-imidazole polyamides with rigid linkers Bioorganic and Medicinal Chemistry,16,11,5899-5907 2008 英語
E.-H. Yao; N. Fukuda; T. Ueno; H. Matsuda; K. Matsumoto; H. Nagase; Y. Matsumoto; A. Takasaka; K. Serie; H. Sugiyama; T. Sawamura Novel gene silencer pyrrole-imidazole polyamide targeting lectin-like oxidized low-density lipoprotein receptor-1 attenuates restenosis of the artery after injury Hypertension,52,1,86-92 2008 英語
T. Takahashi; Y. Asami; E. Kitamura; T. Suzuki; X. Wang; J. Igarashi; A. Morohashi; Y. Shinojima; H. Kanou; K. Saito; T. Takasu; H. Nagase; Y. Harada; K. Kuroda; T. Watanabe; S. Kumamoto; T. Aoyama; Y. Matsumoto; T. Bando; H. Sugiyama; C. Yoshida-Noro; N. Fukuda; N. Hayashi Development of Pyrrole-Imidazole Polyamide for Specific Regulation of Human Aurora Kinase-A and -B Gene Expression Chemistry and Biology,15,8,829-841 2008 英語
J. Fujimoto; T. Bando; M. Minoshima; G. Kashiwazaki; S. Nishijima; K.-i. Shinohara; H. Sugiyama Perylene-conjugated pyrrole polyamide as a sequence-specific fluorescent probe Bioorganic and Medicinal Chemistry,16,22,9741-9744 2008 英語
S.-I. Yonekura; N. Nakamura; T. Doi; H. Sugiyama; K. Yamamoto; S. Yonei; Q.-M. Zhang Recombinant Schizosaccharomyces pombe Nth1 protein exhibits DNA glycosylase activities for 8-oxo-7,8-dihydroguanine and thymine residues oxidized in the methyl group Journal of Radiation Research,48,5,417-424 2007/09 英語
Y. Xu; Y. Hirao; Y. Nishimura; H. Sugiyama I-motif and quadruplex-based device that can control a protein release or bind and release small molecule to influence biological processes Bioorganic and Medicinal Chemistry,15,3,1275-1279 2007 英語
M. Hirota; T. Fujiwara; S. Mineshita; H. Sugiyama; H. Teraoka Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells International Journal of Biochemistry and Cell Biology,39,5,988-996 2007 英語
M. Minoshima; T. Bando; S. Sasaki; K.-I. Shinohara; T. Shimizu; J. Fujimoto; H. Sugiyama DNA alkylation by pyrrole-imidazole seco-CBI conjugates with an indole linker: Sequence-specific DNA alkylation with 10-base-pair recognition through heterodimer formation Journal of the American Chemical Society,129,17,5384-5390 2007 英語
M. Shimizu; P. Gruz; H. Kamiya; C. Masutani; Y. Xu; Y. Usui; H. Sugiyama; H. Harashima; F. Hanaoka; T. Nohmi Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase η Biochemistry,46,18,5515-5522 2007 英語
Y. Xu; R. Tashiro; H. Sugiyama Photochemical determination of different DNA structures Nature Protocols,2,1,78-87 2007 英語
T. Watanabe; R. Tashiro; H. Sugiyama Photoreaction at 5′-(G/C)AA<sup>Br</sup>UT-3′ sequence in duplex DNA: Efficent generation of uracil-5-yl radical by charge transfer Journal of the American Chemical Society,129,26,8163-8168 2007 英語
A. Matsugami; Y. Xu; Y. Noguchi; H. Sugiyama; M. Katahira Structure of a human telomeric DNA sequence stabilized by 8-bromoguanosine substitutions, as determined by NMR in a K<sup>+</sup> solution FEBS Journal,274,14,3545-3556 2007 英語
T. Bando; J. Fujimoto; M. Minoshima; K.-i. Shinohara; S. Sasaki; G. Kashiwazaki; M. Mizumura; H. Sugiyama Detection of CAG repeat DNA sequences by pyrene-functionalized pyrrole-imidazole polyamides Bioorganic and Medicinal Chemistry,15,22,6937-6942 2007 英語
W.D. Wilson; H. Sugiyama First International Meeting on Quadruplex DNA ACS Chemical Biology,2,9,589-594 2007 英語
A. Fukasawa; T. Nagashima; T. Aoyama; N. Fukuda; H. Matsuda; T. Ueno; H. Sugiyama; H. Nagase; Y. Matsumoto Optimization and validation of a high-performance liquid chromatographic method with UV detection for the determination of pyrrole-imidazole polyamides in rat plasma Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences,859,2,272-275 2007 英語
Y. Kageyama; N. Hyochi; K. Kihara; H. Sugiyama The androgen receptor as putative therapeutic target in hormone-refractory prostate cancer Recent Patents on Anti-Cancer Drug Discovery,2,3,203-211 2007 英語
H. Sugiyama Chemical biology that controls DNA structure and function: Lessons in organic chemistry from nature Bulletin of the Chemical Society of Japan,80,5,823-841 2007 英語
Y. Xu; H. Sugiyama Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb) Nucleic Acids Research,34,3,949-954 2006 英語
K.-I. Shinohara; S. Sasaki; M. Minoshima; T. Bando; H. Sugiyama Alkylation of template strand of coding region causes effective gene silencing Nucleic Acids Research,34,4,1189-1195 2006 英語
H. Matsuda; N. Fukuda; T. Ueno; Y. Tahira; H. Ayame; W. Zhang; T. Bando; H. Sugiyama; S. Saito; K. Matsumoto; H. Mugishima; K. Serie Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-β1 promoter for treatment of progressive renal diseases Journal of the American Society of Nephrology,17,2,422-432 2006 英語
K.-I. Shinohara; T. Bando; S. Sasaki; Y. Sakakibara; M. Minoshima; H. Sugiyama Antitumor activity of sequence-specific alkylating agents: Pyrolle-imidazole CBI conjugates with indole linker Cancer Science,97,3,219-225 2006 英語
Y. Kageyama; H. Sugiyama; H. Ayame; A. Iwai; Y. Fujii; L.E. Huang; S. Kizaka-Kondoh; M. Hiraoka; K. Kihara Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element Acta Oncologica,45,3,317-324 2006 英語
T. Bando; S. Sasaki; M. Minoshima; C. Dohno; K.-I. Shinohara; A. Narita; H. Sugiyama Efficient DNA alkylation by a pyrrole-imidazole cbi conjugate with an indole linker: Sequence-specific alkylation with nine-base-pair recognition Bioconjugate Chemistry,17,3,715-720 2006 英語
Y. Xu; Y. Noguchi; H. Sugiyama The new models of the human telomere d[AGGG(TTAGGG)<sub>3</sub>] in K<sup>+</sup> solution Bioorganic and Medicinal Chemistry,14,16,5584-5591 2006 英語
W. Zhang; T. Bando; H. Sugiyama Discrimination of hairpin polyamides with an α-substituted-γ- aminobutyric acid as a 5′-TG-3′ reader in DNA minor groove Journal of the American Chemical Society,128,27,8766-8776 2006 英語
Y. Xu; H. Sugiyama Photochemical approach to probing different DNA structures Angewandte Chemie - International Edition,45,9,1354-1362 2006 英語
S. Sasaki; T. Bando; M. Minoshima; T. Shimizu; K.-I. Shinohara; T. Takaoka; H. Sugiyama Sequence-specific alkylation of double-strand human telomere repeat sequence by pyrrole-imidazole polyamides with indole linkers Journal of the American Chemical Society,128,37,12162-12168 2006 英語
W. Zhang; M. Minoshima; H. Sugiyama Base pair recognition of the stereochemically α-substituted γ-turn of pyrrole/imidazole hairpin polyamides Journal of the American Chemical Society,128,46,14905-14912 2006 英語
T. Bando; H. Sugiyama Synthesis and biological properties of sequence-specific DNA-alkylating pyrrole-imidazole polyamides Accounts of Chemical Research,39,12,935-944 2006 英語
Q.-M. Zhang; S.-I. Yonekura; M. Takao; A. Yasui; H. Sugiyama; S. Yonei DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells DNA Repair,4,1,71-79 2005/01/02 英語
T. Watanabe; T. Bando; Y. Xu; R. Tashiro; H. Sugiyama Efficient generation of 2′-deoxyuridin-5-yl at 5′-(G/C)AA <sup>x</sup>U<sup>x</sup>U-3′ (X = Br, I) sequences in duplex DNA under UV irradiation Journal of the American Chemical Society,127,1,44-45 2005 英語
R. Tashiro; H. Sugiyama Biomolecule-based switching devices that respond inversely to thermal stimuli Journal of the American Chemical Society,127,7,2094-2097 2005 英語
J. Ogamino; H. Mizunuma; H. Kumamoto; S. Takeda; K. Haraguchi; K.T. Nakamura; H. Sugiyama; H. Tanaka 5-Exo versus 6-endo cyclization of nucleoside 2-sila-5-hexenyl radicals: Reaction of 6-(bromomethyl)dimethylsilyl 1′,2′-unsaturated uridines Journal of Organic Chemistry,70,5,1684-1690 2005 英語
K. Kino; H. Sugiyama UVR-induced G-C to C-G transversions from oxidative DNA damage Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis,571,1-2 SPEC. ISS.,33-42 2005 英語
T. Bando; A. Narita; S. Sasaki; H. Sugiyama Specific adenine alkylation by pyrrole-imidazole CBI conjugates Journal of the American Chemical Society,127,40,13890-13895 2005 英語
Y.-M. Lai; N. Fukuda; T. Ueno; H. Matsuda; S. Saito; K. Matsumoto; H. Ayame; T. Bando; H. Sugiyama; H. Mugishima; K. Serie Synthetic pyrrole-imidazole polyamide inhibits expression of the human transforming growth factor-β1 gene Journal of Pharmacology and Experimental Therapeutics,315,2,571-575 2005 英語
K. Kino; Y. Shimizu; K. Sugasawa; H. Sugiyama; F. Hanaoka Nucleotide Excision Repair of 5-Formyluracil in Vitro Is Enhanced by the Presence of Mismatched Bases Biochemistry,43,10,2682-2687 2004 英語
T. Bando; A. Narita; A. Iwai; K. Kihara; H. Sugiyama C-H to N Substitution Dramatically Alters the Sequence-Specific DNA Alkylation, Cytotoxicity, and Expression of Human Cancer Cell Lines Journal of the American Chemical Society,126,11,3406-3407 2004 英語
M.S.R.C. Murty; H. Sugiyama Biology of N-methylpyrrole-N-methylimidazole hairpin polyamide Biological and Pharmaceutical Bulletin,27,4,468-474 2004 英語
K.-I. Shinohara; A. Narita; T. Oyoshi; T. Bando; H. Teraoka; H. Sugiyama Sequence-Specific Gene Silencing in Mammalian Cells by Alkylating Pyrrole-Imidazole Polyamides Journal of the American Chemical Society,126,16,5113-5118 2004 英語
Y. Xu; H. Sugiyama Highly efficient photochemical 2′-deoxyribonolactone formation at the diagonal loop of a 5-iodouracil-containing antiparallel G-quartet Journal of the American Chemical Society,126,20,6274-6279 2004 英語
Y. Xu; Y.X. Zhang; H. Sugiyama; T. Umano; H. Osuga; K. Tanaka (P)-helicene displays chiral selection in binding to Z-DNA Journal of the American Chemical Society,126,21,6566-6567 2004 英語
T. Bando; A. Narita; K. Asada; H. Ayame; H. Sugiyama Enantioselective DNA alkylation by a pyrrole-imidazole S-CBI conjugate Journal of the American Chemical Society,126,29,8948-8955 2004 英語
A. Inase; T.S. Kodama; J. Sharif; V. Xu; H. Ayame; H. Sugiyama; S. Iwai Binding of distamycin A to UV-damaged DNA Journal of the American Chemical Society,126,35,11017-11023 2004 英語
Q.-M. Zhang; K. Hashiguchi; K. Kino; H. Sugiyama; S. Yonei Ntg1 and Ntg2 proteins as 5-formyluracil-DNA glycosylases/AP lyases in Saccharomyces cerevisiae International Journal of Radiation Biology,79,5,341-349 2003/05 英語
M. Hori; S. Yonei; H. Sugiyama; K. Kino; K. Yamamoto; Q.-M. Zhang Identification of high excision capacity for 5-hydroxymethyluracil mispaired with guanine in DNA of Escherichia coli MutM, Nei and Nth DNA glycosylases Nucleic Acids Research,31,4,1191-1196 2003/02/15 英語
T. Iiyama; M. Chikira; T. Oyoshi; H. Sugiyama Deglyco-peplomycin metal complexes on DNA fibers: A role of the sugar moiety for the stability and the orientation of the complexes Journal of Biological Inorganic Chemistry,8,1-2,135-140 2003 英語
T. Oyoshi; K. Kawai; H. Sugiyama Efficient C2′α-hydroxylation of deoxyribose in protein-induced Z-form DNA Journal of the American Chemical Society,125,6,1526-1531 2003 英語
T. Oyoshi; W. Kawakami; A. Narita; T. Bando; H. Sugiyama Inhibition of transcription at a coding sequence by alkylating polyamide Journal of the American Chemical Society,125,16,4752-4754 2003 英語
T. Bando; A. Narita; I. Saito; H. Sugiyama Highly efficient sequence-specific DNA interstrand cross-linking by pyrrole/imidazole CPI conjugates Journal of the American Chemical Society,125,12,3471-3485 2003 英語
R. Takahashi; T. Bando; H. Sugiyama Specific alkylation of human telomere repeats by hairpin pyrrole-imidazole polyamide Bioorganic and Medicinal Chemistry,11,12,2503-2509 2003 英語
T. Bando; H. Iida; Z.-F. Tao; A. Narita; N. Fukuda; T. Yamori; H. Sugiyama Sequence specificity, reactivity, and antitumor activity of DNA-alkylating pyrrole-imidazole diamides Chemistry and Biology,10,8,751-758 2003 英語
Y. Xu; R. Ikeda; H. Sugiyama 8-Methylguanosine: A Powerful Z-DNA Stabilizer Journal of the American Chemical Society,125,44,13519-13524 2003 英語
R. Tashirot; H. Sugiyama Unique Charge Transfer Properties of the Four-Base π-Stacks in Z-DNA Journal of the American Chemical Society,125,50,15282-15283 2003 英語
R. Tashiro; H. Sugiyama A Nanothermometer Based on the Different π Stackings of B- and Z-DNA Angewandte Chemie - International Edition,42,48,6018-6020 2003 英語
S. Iwai; A. Inase; S. Jafar; M. Higurashi; T. Ohtsuki; Y. Xu; H. Sugiyama Towards artificial repair of UV-damaged DNA: studies on drug binding and alkali hydrolysis. Nucleic acids research. Supplement (2001),3,181-182 2003 英語
H. Ayame; T. Saito; T. Bando; N. Fukuda; H. Sugiyama Fmoc solid-phase synthesis and its application to pyrrole-imidazole polyamides. Nucleic acids research. Supplement (2001),3,67-68 2003 英語
R. Tashiro; H. Sugiyama Photochemistry of bromouracil containing Z-DNA. Nucleic acids research. Supplement (2001),3,69-70 2003 英語
Y. Xu; H. Sugiyama Photoreactivity of 5-iodouracil-containing telomeric DNA. Nucleic acids research. Supplement (2001),3,71-72 2003 英語
I. Miyabe; Q.-M. Zhang; K. Kino; H. Sugiyama; M. Takao; A. Yasui; S. Yonei Identification of 5-formyluracil DNA glycosylase activity of human hNTH1 protein Nucleic Acids Research,30,15,3443-3448 2002/08/01 英語
K. Hashiguchi; Q.M. Zhang; H. Sugiyama; S. Ikeda; S. Yonei Characterization of 2-hydroxyadenine DNA glycosylase activity of Escherichia coli MutY protein International Journal of Radiation Biology,78,7,585-592 2002/07 英語
Y. Sakagami; T. Murai; H. Sugiyama A third arm on the chest: Implications for the cortical reorganization theory of phantom limbs [8] Journal of Neuropsychiatry and Clinical Neurosciences,14,1,90-91 2002 英語
K. Fujimoto; H. Iida; M. Kawakami; T. Bando; Z.-F. Tao; H. Sugiyama Sequence-specific protection of plasmid DNA from restriction endonuclease hydrolysis by pyrrole-imidazole-cyclopropapyrroloindole conjugates Nucleic Acids Research,30,17,3748-3753 2002 英語
T. Oyoshi; A.H.-J. Wang; H. Sugiyama Photoreactivity of 5-lodouracil-containing DNA-Sso7d complex in solution: The protein-induced DNA kink causes intrastrand hydrogen abstraction from the 5-methyl of thymine at the 5′ side Journal of the American Chemical Society,124,10,2086-2087 2002 英語
T. Bando; A. Narita; I. Saito; H. Sugiyama Molecular design of a pyrrole-imidazole hairpin polyamides for effective DNA alkylation Chemistry - A European Journal,8,20,4781-4790 2002 英語
Y. Xu; K. Kino; H. Sugiyama The conformational study of two carbocyclic nucleosides: Why carbocyclic nucleic acids (CarNAs) form more stable duplexes with RNA than DNA does Journal of Biomolecular Structure and Dynamics,20,3,437-446 2002 英語
T. Oyoshi; W. Kawakami; T. Bando; A. Narita; H. Sugiyama Regulation of gene expression by sequence-specific alkylating polyamide. Nucleic Acids Res Suppl,2,259-260 2002 英語
A. Narita; T. Bando; H. Sugiyama Molecular design of hairpin polyamide possessing sequence-specific alkylation activity. Nucleic Acids Res Suppl,2,109-110 2002 英語
I. Miyabe; Q.-M. Zhang; H. Sugiyama; K. Kino; S. Yonei Mutagenic effects of 5-formyluracil on a plasmid vector during replication in Escherichia coli International Journal of Radiation Biology,77,1,53-58 2001/01 英語
T. Bando; H. Iida; I. Saito; H. Sugiyama Sequence-specific DNA interstrand cross-linking by imidazole-pyrrole CPI conjugate Journal of the American Chemical Society,123,21,5158-5159 2001 英語
K. Kino; H. Sugiyama Possible cause of G·C→C·G transversion mutation by guanine oxidation product, imidazolone Chemistry and Biology,8,4,369-378 2001 英語
Y. Hiraku; S. Oikawa; K. Kuroki; H. Sugiyama; I. Saito; S. Kawanishi Amplification of bleomycin-induced DNA cleavage at cytosine residues 3′ to GGG sequences by pyrrole triamide Biochemical Pharmacology,61,3,351-356 2001 英語
P.G. Baraldi; G. Balboni; M.G. Pavani; G. Spalluto; M.A. Tabrizi; E. De Clercq; J. Balzarini; T. Bando; H. Sugiyama; R. Romagnoli Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders Journal of Medicinal Chemistry,44,16,2536-2543 2001 英語
T. Fujiwara; M. Kimoto; H. Sugiyama; I. Hirao; S. Yokoyama Synthesis of 6-(2-thienyl)purine nucleoside derivatives that form unnatural base pairs with pyridin-2-one nucleosides Bioorganic and Medicinal Chemistry Letters,11,16,2221-2223 2001 英語
Q.-M. Zhang; I. Miyabe; Y. Matsumoto; K. Kino; H. Sugiyama; S. Yonei Identification of repair enzymes for 5-formyluracil in DNA: nth, nei, and mutM proteins of Escherichia coli Journal of Biological Chemistry,275,45,35471-35477 2000/11/10 英語
S. Kawanishi; S. Oikawa; M. Kawanishi; H. Sugiyama; I. Saito; L. Strekowski; W.D. Wilson Amplification of pepleomycin-mediated DNA cleavage and apoptosis by unfused aromatic cations Biochemistry,39,43,13210-13215 2000 英語
Z.-F. Tao; I. Saito; H. Sugiyama Highly cooperative DNA dialkylation by the homodimer of imidazole - pyrrole diamide - CPI conjugate with vinyl linker Journal of the American Chemical Society,122,8,1602-1608 2000 英語
M. Hirota; T. Matsuno; T. Fujiwara; H. Sugiyama; S. Mineshita Enhanced cytotoxicity in a Z-photoisomer of a benzopyran derivative of propolis Journal of Natural Products,63,3,366-370 2000 英語
T. Oyoshi; H. Sugiyama Mechanism of DNA strand scission induced by (1,10- phenanthroline)copper complex: Major direct DNA cleavage is not through 1\\',2\\'-dehydronucleotide intermediate nor β-elimination of forming ribonolactone [14] Journal of the American Chemical Society,122,26,6313-6314 2000 英語
S. Ikeda; I. Saito; H. Sugiyama Metallo-bleomycin cleaves parallel-stranded DNA similarly to B-DNA Tetrahedron Letters,41,20,3919-3922 2000 英語
Q.-M. Zhang; H. Sugiyama; I. Miyabe; S. Matsuda; K. Kino; I. Saito; S. Yonei Replication in vitro and cleavage by restriction endonuclease of 5- formyluracil- and 5-hydroxymethyluracil-containing oligonucleotides International Journal of Radiation Biology,75,1,59-65 1999/01 英語
K. Sakamoto; D. Kiga; K. Komiya; H. Gouzu; S. Yokoyama; S. Ikeda; H. Sugiyama; M. Hagiya State transitions by molecules BioSystems,52,1-3,81-91 1999 英語
Z.-F. Tao; T. Fujiwara; I. Saito; H. Sugiyama Sequence-specific alkylation of DNA by duocarmycin A and its novel derivatives bearing Py/Im polyamides Nucleosides and Nucleotides,18,6-7,1615-1616 1999 英語
Z.-F. Tao; T. Fujiwara; I. Saito; H. Sugiyama Sequence-specific DNA alkylation by hybrid molecules between segment A of duocarmycin A and pyrrole/imidazole diamide Angewandte Chemie - International Edition,38,5,650-653 1999 英語
C.L. Chepanoske; S.L. Porello; T. Fujiwara; H. Sugiyama; S.S. David Substrate recognition by Escherichia coli MutY using substrate analogs Nucleic Acids Research,27,15,3197-3204 1999 英語
X.-L. Yang; R.B. Hubbard IV; M. Lee; Z.-F. Tao; H. Sugiyama; A.H.-J. Wang Imidazole-imidazole pair as a minor groove recognition motif for T:G mismatched base pairs Nucleic Acids Research,27,21,4183-4190 1999 英語
Z.-F. Tao; T. Fujiwara; I. Saito; H. Sugiyama Rational design of sequence-specific DNA alkylating agents based on duocarmycin A and pyrrole-imidazole hairpin polyamides Journal of the American Chemical Society,121,21,4961-4967 1999 英語
K. Kawai; I. Saito; H. Sugiyama Conformation-dependent photochemistry of 5-halouracil-containing DNA: Stereospecific 2\\'α-hydroxylation of deoxyribose in Z-form DNA [7] Journal of the American Chemical Society,121,6,1391-1392 1999 英語
T. Fujiwara; Z.-F. Tao; Y. Ozeki; I. Saito; A.H.-J. Wang; M. Lee; H. Sugiyama Modulation of sequence specificity of duocarmycin-dependent DNA alkylation by pyrrole-imidazole triamides [6] Journal of the American Chemical Society,121,33,7706-7707 1999 英語
K. Kawai; I. Saito; E. Kawashima; Y. Ishido; H. Sugiyama Intrastrand 2\\'β hydrogen abstraction of 5\\'-adjacent deoxyguanosine by deoxyuridin-5-yl in Z-form DNA Tetrahedron Letters,40,13,2589-2592 1999 英語
K. Kawai; I. Saito; H. Sugiyama Photochemical halogen-exchange reaction of 5-iodouracil-containing oligonucleotides Tetrahedron Letters,40,31,5721-5724 1999 英語
X.-L. Yang; H. Sugiyama; S. Ikeda; I. Saito; A.H.-J. Wang Structural studies of a stable parallel-stranded DNA duplex incorporating isoguanine: Cytosine and isocytosine: Guanine basepairs by nuclear magnetic resonance spectroscopy Biophysical Journal,75,3,1163-1171 1998 英語
K. Fujimoto; H. Sugiyama; I. Saito Sequence dependent photoreduction of 5-bromouracil-containing oligonucleotides via electron transfer Tetrahedron Letters,39,15,2137-2140 1998 英語
I. Saito; T. Nakamura; K. Nakatani; Y. Yoshioka; K. Yamaguchi; H. Sugiyama Mapping of the hot spots for DNA damage by one-electron oxidation: Efficacy of GG doublets and GGG triplets as a trap in long-range hole migration [11] Journal of the American Chemical Society,120,48,12686-12687 1998 英語
S. Ikeda; I. Saito; H. Sugiyama Facile synthesis of puromycin-tethered oligonucleotides at the 3\\'-end Tetrahedron Letters,39,33,5975-5978 1998 英語
K. Kawai; I. Saito; H. Sugiyama Stabilization of Hoogsteen base pairing by introduction of NH<sub>2</sub> group at the C8 position of adenine Tetrahedron Letters,39,29,5221-5224 1998 英語
K. Kino; H. Sugiyama Molecular mechanism of GG-specific photooxidation of DNA Journal of Medical and Dental Sciences,45,3,161-169 1998 英語
Q.-M. Zhang; H. Sugiyama; I. Miyabe; S. Matsuda; I. Saito; S. Yonei Replication of DNA templates containing 5-formyluracil, a major oxidative lesion of thymine in DNA Nucleic Acids Research,25,20,3969-3973 1997/10/15 英語
I. Saito; M. Takayama; H. Sugiyama; T. Nakamura Design of photochemical DNA-cleaving molecules via electron transfer Journal of Photochemistry and Photobiology A: Chemistry,106,1-3,141-144 1997 英語
H. Sugiyama; K. Fujimoto; I. Saito Preferential C1\\' hydrogen abstraction by a uracilyl radical in a DNA-RNA hybrid Tetrahedron Letters,38,46,8057-8060 1997 英語
J. Caceres-Cortes; H. Sugiyama; K. Ikudome; I. Saito; A.H.-J. Wang Interactions of deglycosylated cobalt(III)-pepleomycin (green form) with DNA based on NMR structural studies Biochemistry,36,33,9995-10005 1997 英語
J. Caceres-Cortes; H. Sugiyama; K. Ikudome; I. Saito; A.H.-J. Wang Structures of cobalt(III)-pepleomycin and cobalt(III)-deglycopepleomycin (green fonns) determined by NMR studies European Journal of Biochemistry,244,3,818-828 1997 英語
H. Sugiyama; S. Matsuda; K. Kino; Q.-M. Zhang; S. Yonei; I. Saito New synthetic method of 5-formyluracil-containing oligonucleotides and their melting behavior Tetrahedron Letters,37,50,9067-9070 1996/12/09 英語
H. Sugiyama; I. Saito Theoretical studies of GG-specific photocleavage of DNA via electron transfer: Significant lowering of ionization potential and 5\\'-localization of HOMO of stacked GG bases in B-form DNA Journal of the American Chemical Society,118,30,7063-7068 1996 英語
H. Sugiyama; K. Fujimoto; I. Saito; E. Kawashima; T. Sekine; Y. Ishido Evidence for intrastrand C2′ hydrogen abstraction in photoirradiation of 5-halouracil-containing oligonucleotides by using stereospecifically C2′-deuterated deoxyadenosine Tetrahedron Letters,37,11,1805-1808 1996 英語
H. Sugiyama; S. Ikeda; I. Saito Remarkably stable parallel-stranded oligonucleotides containing 5-methylisocytosine and isoquanine Journal of the American Chemical Society,118,41,9994-9995 1996 英語
H. Sugiyama; K. Kawai; A. Matsunaga; K. Fujimoto; I. Saito; H. Robinson; A.H.-J. Wang Synthesis, structure and thermodynamic properties of 8-methylguanine-containing oligonucleotides: Z-DNA under physiological salt conditions Nucleic Acids Research,24,7,1272-1278 1996 英語
H. Sugiyama; K. Hatano; I. Saito; S. Amontov; K. Taira Catalytic activities of hammerhead ribozymes with a triterpenoid linker instead of stem/loop II FEBS Letters,392,3,215-219 1996 英語
H. Sugiyama; K. Fujimoto; I. Saito Stereospecific 1,2-hydride shift in ribonolactone formation in the photoreaction of 2′-iododeoxyuridine Journal of the American Chemical Society,117,10,2945-2946 1995 英語
H. Sugiyama; K. Yamashita; T. Fujiwara; I. Saito Apoprotein-assisted unusual cyclization of neocarzinostatin chromophore Tetrahedron,50,5,1311-1325 1994 英語
H. Sugiyama; T. Fujiwara; I. Saito Activation of neocarzinostatin-chromophore by 4-hydroxythiophenol: Intramolecular radical trapping of biradical intermediate Tetrahedron Letters,35,47,8825-8828 1994 英語
H. Sugiyama; K. Ohmori; I. Saito Oligonucleotides containing a radical trap: The trapping of deoxyribose C4′ radical in bleomycin-mediated reactions Journal of the American Chemical Society,116,22,10326-10327 1994 英語
H. Sugiyama; T. Fujiwara; A. Ura; T. Tashiro; K. Yamamoto; S. Kawanishi; I. Saito Chemistry of thermal degradation of abasic sites in DNA. Mechanistic investigation on thermal DNA strand cleavage of alkylated DNA Chemical Research in Toxicology,7,5,673-683 1994 英語
H. Sugiyama; Y. Tsutsumi; K. Fujimoto; I. Saito Photoinduced deoxyribose C2′ oxidation in DNA. Alkali-dependent cleavage of erythrose-containing sites via a retroaldol reaction Journal of the American Chemical Society,115,11,4443-4448 1993 英語
T. Tanaka; T. Yamagami; Y. Oka; T. Nomura; H. Sugiyama The scid mutation in mice causes defects in the repair system for both double-strand DNA breaks and DNA cross-links Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis,288,2,277-280 1993 英語
K. Yamamoto; H. Sugiyama; S. Kawanishi Concerted DNA recognition and novel site-specific alkylation by duocarmycin A with distamycin A Biochemistry,32,4,1059-1066 1993 英語
H. Sugiyama; K. Ohmori; K.L. Chan; M. Hosoda; A. Asai; H. Saito; I. Saito A novel guanine N3 alkylation by antitumor antibiotic duocarmycin A Tetrahedron Letters,34,13,2179-2182 1993 英語
K.L. Chan; Y. Iitaka; H. Noguchi; H. Sugiyama; I. Saito; U. Sankawa 6α-Hydroxyeurycomalactone, a quassinoid from Eurycoma longifolia Phytochemistry,31,12,4295-4298 1992 英語
H. Sugiyama; K. Yamashita; M. Nishi; I. Saito A novel cyclization pathway in activation of neocarzinostatin chromophore by thiol under physiological conditions Tetrahedron Letters,33,4,515-518 1992 英語
H. Sugiyama; T. Fujiwara; H. Kawabata; N. Yoda; N. Hirayama; I. Saito Chemistry of neocarzinostatin-mediated cleavage of oligonucleotides. Competitive ribose C5′ and C4′ hydroxylation Journal of the American Chemical Society,114,14,5573-5578 1992 英語
M. Jisaka; M. Kawanaka; H. Sugiyama; K. Takegawa; M.A. Huffman; H. Ohigashi; K. Koshimizu Antischistosomal activities of sesquiterpene lactones and steroid glucosides from Vernonia amygdalina, possibly used by wild chimpanzees against parasite-related diseases. Bioscience, biotechnology, and biochemistry,56,5,845-846 1992 英語
H. Sugiyama; T. Sera; Y. Dannoue; R. Marumoto; I. Saito Bleomycin-Mediated Degradation of Aristeromycin-Containing DNA. Novel Dehydrogenation Activity of Iron<sup>II</sup>-Bleomycin Journal of the American Chemical Society,113,6,2290-2295 1991 英語
K.L. Chan; H. Sugiyama; I. Saito; M. Hara DNA cleavage reaction of antitumour antibiotic, kapurimycin A3, with deoxytetranucleotide d(CGCG)<sub>2</sub> Tetrahedron Letters,32,52,7719-7722 1991 英語
S. Matsugo; S. Kawanishi; K. Yamamoto; H. Sugiyama; T. Matsuura; I. Saito Bis(hydroperoxy)naphthaldiimide as a "photo-Fenton reagent": Sequence-specific photocleavage of DNA Angewandte Chemie (International Edition in English),30,10,1351-1353 1991 英語
H. Sugiyama; H. Kawabata; T. Fujiwara; Y. Dannoue; I. Saito Specific detection of C-4′ hydroxylated abasic sites generated by bleomycin and neocarzinostatin in DNA Journal of the American Chemical Society,112,13,5252-5257 1990 英語
H. Sugiyama; Y. Tsutsumi; I. Saito Highly sequence selective photoreaction of 5-bromouracil-containing deoxyhexanucleotides Journal of the American Chemical Society,112,18,6720-6721 1990 英語
H. Sugiyama; M. Hosoda; I. Saito; A. Asai; H. Saito Covalent alkylation of dna with duocarmycin A. Identification of abasic site structure Tetrahedron Letters,31,49,7197-7200 1990 英語
I. Saito; H. Kawabata; T. Fujiwara; H. Sugiyama; T. Matsuura A novel ribose C-4′ hydroxylation pathway in neocarzinostatin-mediated degradation of oligonucleotides Journal of the American Chemical Society,111,21,8302-8303 1989 英語
H. Kawabata; H. Takeshita; T. Fujiwara; H. Sugiyama; T. Matsuura; I. Saito Chemistry of neocarzinostatin-mediated degradation of d(GCATGC). Mechanism of spontaneous thymine release Tetrahedron Letters,30,32,4263-4266 1989 英語
H. Sugiyama; T. Tashiro; Y. Dannoue; T. Miwa; T. Matsuura; I. Saito Metallo-bleomycin-mediated degradation of deoxytetranucleotides. Unusual C-4′ hydroxylation at terminal cytidine Tetrahedron Letters,30,51,7213-7216 1989 英語
Hiroshi Sugiyama; Osamu Nittono Characterization of porous silicon layers by means of X-ray double-crystal diffractometry ISIJ International,29,3,223-228 1989 英語
I. Saito; T. Morii; H. Sugiyama; T. Matsuura; C.F. Meares; S.M. Hecht Photoinduced DNA strand scission by cobalt bleomycin green complex Journal of the American Chemical Society,111,6,2307-2308 1989 英語
I. Saito; T. Morii; T. Obayashi; T. Sera; H. Sugiyama; T. Matsuura Synthetic cobalt bleomycin models as a photochemical DNA cleaver Journal of the Chemical Society - Series Chemical Communications,6,360-362 1989 英語
Hiroshi Sugiyama; Osamu Nittono Annealing effect on lattice distortion in anodized porous silicon layers Japanese Journal of Applied Physics, Part 2: Letters,28,11,L2013-L2016 1989 英語
H. Shizuka; M. Serizawa; H. Kobayashi; K. Kameta; H. Sugiyama; T. Matsuura; I. Saito Excited-state behavior of tryptamine and related indoles. Remarkably efficient intramolecular proton-induced quenching Journal of the American Chemical Society,110,6,1726-1732 1988 英語
H. Sugiyama; C. Xu; N. Murugesan; S.M. Hecht; G.A. Van Der Marel; J.H. Van Boom Chemistry of the alkali-labile lesion formed from iron(II) bleomycin and d(CGCTTTAAAGCG) Biochemistry,27,1,58-67 1988 英語
G.M. Ehrenfeld; J.B. Shipley; D.C. Heimbrook; H. Sugiyama; E.C. Long; J.H. Van Boom; G.A. Van Der Marel; N.J. Oppenheimer; S.M. Hecht Copper-dependent cleavage of DNA by bleomycin Biochemistry,26,3,931-942 1987 英語
H. Sugiyama; R.E. Kilkuskie; L.-H. Chang; L.-T. Ma; S.M. Hecht; G.A. Van Der Marel; J.H. Van Boom DNA strand scission by bleomycin: Catalytic cleavage and strand selectivity Journal of the American Chemical Society,108,13,3852-3854 1986 英語
H. Akiyama; M. Kameyama; I. Akiguchi; H. Sugiyama; T. Kawamata; H. Fukuyama; H. Kimura; M. Matsushita; T. Takeda Periodic acid-Schiff (PAS)-positive, granular structures increase in the brain of senescence accelerated mouse (SAM) Acta Neuropathologica,72,2,124-129 1986 英語
H. Sugiyama; C. Xu; N. Murugesan; S.M. Hecht Structure of the alkali-labile product formed during iron(II)-bleomycin-mediated DNA strand scission Journal of the American Chemical Society,107,13,4104-4105 1985 英語
H. Sugiyama; G.M. Ehrenfeld; J.B. Shipley; R.E. Kilkuskie; L.-H. Chang; S.M. Hecht DNA strand scission by bleomycin group antibiotics Journal of Natural Products,48,6,869-877 1985 英語
N. Murugesan; C. Xu; G.M. Ehrenfeld; H. Sugiyama; R.E. Kilkuskie; L.O. Rodriguez; L.-H. Chang; S.M. Hecht Analysis of products formed during bleomycin-mediated DNA degradation Biochemistry,24,21,5735-5744 1985 英語
I. Saito; S. Muramatsu; H. Sugiyama; A. Yamamoto; T. Matsuura Regio-controlled hydrogen-deuterium exchange of biologically important indoles under uv irradiation Tetrahedron Letters,26,48,5891-5894 1985 英語
H. Sugiyama; R.E. Kilkuskie; S.M. Hecht; G.A. Van Der Marel; J.H. Van Boom An efficient, site-specific DNA target for bleomycin Journal of the American Chemical Society,107,25,7765-7767 1985 英語
I. Saito; H. Sugiyama; T. Matsuura; K. Fukuyama Stacking interaction between tryptophan and uracil in a synthetic model compound Tetrahedron Letters,26,37,4467-4470 1985 英語
I. Saito; H. Sugiyama; A. Yamamoto; S. Muramatsu; T. Matsuura Photochemical hydrogen-deuterium exchange reaction of tryptophan. The role in nonradiative decay of singlet tryptophan Journal of the American Chemical Society,106,15,4286-4287 1984 英語
I. Saito; H. Sugiyama; T. Matsuura; K. Fukuyama; Y. Katsube Photochemical reaction between tryptophan and thymine Tetrahedron Letters,25,30,3243-3246 1984 英語
I. Saito; H. Sugiyama; T. Matsuura; K. Ueda; T. Komano A new procedure for determining thymine residues in DNA sequencing. Photoinduced cleavage of DNA fragments in the presence of spermine Nucleic Acids Research,12,6,2879-2885 1984 英語
I. Saito; H. Sugiyama; T. Matsuura Photoreaction of thymidine with alkylamines. Application to selective removal of thymine from DNA Journal of the American Chemical Society,105,4,956-962 1983 英語
I. Saito; H. Sugiyama; T. Matsuura Isolation and characterization of a thymine-lysine adduct in UV-irradiated nuclei. The role of thymine-lysine photoaddition in photo-cross-linking of proteins to DNA Journal of the American Chemical Society,105,23,6989-6991 1983 英語
I. Saito; H. Sugiyama; S. Ito; N. Furukawa; T. Matsuura A novel photoreaction of thymidine with lysine. Photoinduced migration of thymine from DNA to lysine Journal of the American Chemical Society,103,6,1598-1600 1981 英語
I. Saito; H. Sugiyama; N. Furukawa; T. Matsuura Photochemical ring opening of thymidine and thymine in the presence of primary amines Tetrahedron Letters,22,34,3265-3268 1981 英語
T. Shono; H. Ohmizu; S. Kawakami; H. Sugiyama Electroreductive hydrocoupling of activated olefins with ketones or aldehydes in the presence of trimethylchlorosilane Tetrahedron Letters,21,52,5029-5032 1980 英語
I. Saito; S. Ito; H. Sugiyama; M. Akita; T. Matsuura Photochemical reaction of 8-azaxanthine with nucleophiles Tetrahedron Letters,20,42,4065-4066 1979 英語
N. Nakanishi; Y. Murakami; M. Tobioka; H. Sugiyama; S. Kachi Elastic properties of (NH<sub>4</sub>)<sub>2</sub>SO<sub>4</sub> in the paraelectrlc region Journal of the Physical Society of Japan,35,3,947- 1973 英語
S. Ito; J. Tsunetsugu; T. Kanno; H. Sugiyama; H. Takeshita Syntheses and reactions of deuterated troponoids Tetrahedron Letters,7,18,2048- 1966 英語
J. Fujimoto; T. Bando; M. Minoshima; G. Kashiwazaki; S. Nishijima; K.-i. Shinohara; H. Sugiyama Perylene-conjugated pyrrole polyamide as a sequence-specific fluorescent probe Bioorganic and Medicinal Chemistry 英語

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学会発表等 > 学会発表等
(文系研究者の一般的な学会報告の業績は「講演等」を参照してください)
著者名 タイトル 書誌情報等 年月 査読の有無 言語
中田栄司,上床知佐奈,劉芳芳,清中茂樹,森泰生,勝田陽介,遠藤政幸,杉山弘,森井孝 DNA origami上への機能性タンパク質固定化技術の開発 第5回バイオ関連化学シンポジウム,つくば国際会議場「エポカルつくば」,2011.9.12-14 2011 日本語
C. Huang; T. Saeki; M. Endo; H. Sugiyama; C.-H. Weng; G.-B. Lee; K. Sugano; T. Tsuchiya; O. Tabata Configurable assembly of DNA origami on MEMS by microfluidic device NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems,197-200 2011 英語
E. Nakata, C. Uwatoko, F.F. Liew, S. Kiyonaka, Y. Mori, Y. Katsuta, M. Endo, H. Sugiyama, T. Morii Development of the immobilization technology of functional proteins on DNA origami The 38th International Symposium on Nucleic Acid Chemistry,Hokkaido,2011.11.9-11 2011 英語
H. Sugiyama; M. Endo Direct observation and control of enzymatic reaction in DNA frame 7th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2010,133-134 2010 英語
Y. Okabe; H. Sugiyama Shape-variable sandwich structure with SMA honeycomb core and CFRP skins Proceedings of SPIE - The International Society for Optical Engineering,7288 2009 英語
M. Endo; H. Sugiyama Three-dimensional DNA nanostructures constructed by folding of multiple rectangles. Nucleic acids symposium series (2004),53,81-82 2009 英語
M. Minoshima; T. Bando; K. Shinohara; H. Sugiyama Molecular design of sequence specific DNA alkylating agents. Nucleic acids symposium series (2004),53,69-70 2009 英語
Y. Okabe; H. Sugiyama; T. Inayoshi Lightweight actuator structure with SMA honeycomb core and CFRP skins Proceedings of the ASME Conference on Smart Materials, Adaptive Structures and Intelligent Systems 2009, SMASIS2009,2,1-9 2009 英語
G. Kashiwazaki; T. Bando; H. Sugiyama Sequence-specific alkylation of DNA by pyrrole-imidazole polyamides through cooperative interaction. Nucleic acids symposium series (2004),52,365-366 2008 英語
M. Minoshima; J. Chou; S. Lefebvre; T. Bando; K. Shinohara; J.M. Gottesfeld; H. Sugiyama Targeting specific gene by alkylating pyrrole-imidazole polyamides. Nucleic acids symposium series (2004),52,363-364 2008 英語
T. Mashimo; Y. Sannohe; H. Yagi; H. Sugiyama Folding pathways of hybrid-1 and hybrid-2 G-quadruplex structures. Nucleic acids symposium series (2004),52,409-410 2008 英語
Y. Sannohe; K. Sato; A. Matsugami; K. Shinohara; T. Mashimo; M. Katahira; H. Sugiyama Orientation of ends of G-quadruplex structure investigated with end-extended oligonucleotides. Nucleic acids symposium series (2004),52,171-172 2008 英語
H. Yagi; T. Mashimo; Y. Sannohe; H. Sugiyama Structural stability analysis of the intermediates in the folding pathway of human telomeric hybrid-1 G-quadruplex based on fragment molecular orbital method. Nucleic acids symposium series (2004),52,161-162 2008 英語
H. Sugiyama Chemical biology that controls DNA structure and function. Nucleic acids symposium series (2004),51,59-60 2007 英語
Y. Xu; H. Sato; K. Shinohara; M. Komiyama; H. Sugiyama T-loop formation by human telomeric G-quadruplex. Nucleic acids symposium series (2004),51,243-244 2007 英語
R. Tashiro; A.H.-J. Wang; H. Sugiyama Photoreactivation of DNA by an Archaeal nucleoprotein Sso7d Proceedings of the National Academy of Sciences of the United States of America,103,45,16655-16659 2006 英語
A. Matsugami; H. Tsuchibayashi; Y. Xu; Y. Noguchi; H. Sugiyama; M. Katahira The new models of the human telomere DNA in K+ solution revealed by NMR analysis assisted by the incorporation of 8-bromoguanines. Nucleic acids symposium series (2004),50,45-46 2006 英語
Y. Xu; S. Yamazaki; H. Osuga; H. Sugiyama The recognition of higher-order G-quadruplex by chiral cyclic-helicene molecules. Nucleic acids symposium series (2004),50,183-184 2006 英語
R. Tashiro; A.H. Wang; H. Sugiyama Detection of photoinduced electron transfer from Sso7d to DNA. Nucleic acids symposium series (2004),50,149-150 2006 英語
S. Sasaki; M. Minoshima; T. Shimizu; J. Fujimoto; K. Shinohara; T. Bando; H. Sugiyama The biological impact of sequence-specific DNA alkylation by pyrrole-imidazole polyamides. Nucleic acids symposium series (2004),50,111-112 2006 英語
Y. Xu; H. Sugiyama Structural and functional characterizations of the G-quartet and i-motif elements in retinoblastoma susceptibility genes (Rb). Nucleic acids symposium series (2004),49,177-178 2005 英語
K. Shinohara; S. Sasaki; T. Bando; H. Sugiyama Sequence-specific gene silencing by alkylating Py-Im polyamide. Nucleic acids symposium series (2004),49,75-76 2005 英語
W. Hasiba; Y. Xu; H. Sugiyama Reactivity of 2\\'-deoxyuridin-1\\'-yl radical in various DNA structures. Nucleic acids symposium series (2004),49,179-180 2005 英語
Y. Okugawa; C. Otsuka; D. Loakes; H. Sugiyama; K. Negishi UVA-induced degradation of 8-hydroxyguanine in oligonucleotide and the effect on its activities in yeast oligonucleotide transformation assay. Nucleic acids symposium series (2004),48,287-288 2004 英語
T. Watanabe; T. Bando; Y. Xu; H. Sugiyama Efficient generation of 2\\'-deoxyuridin-5-yl at 5\\'-(G/C)AA(X)U(X)U-3\\' (X = Br, I) sequences in duplex DNA under UV-irradiation. Nucleic acids symposium series (2004),48,19-20 2004 英語
S. Sasaki; A. Narita; T. Bando; H. Sugiyama Molecular design of alkylating pyrrole-imidazole polyamides with indole linker. Nucleic acids symposium series (2004),48,205-206 2004 英語
K. Kino; N. Ito; K. Sugasawa; H. Sugiyama; F. Hanaoka Translesion synthesis by human DNA polymerase eta across oxidative products of guanine. Nucleic acids symposium series (2004),48,171-172 2004 英語
R. Tashiro; H. Sugiyama The molecular-thermometer based on B-Z transition of DNA. Nucleic acids symposium series (2004),48,89-90 2004 英語
A. Inase; T.S. Kodama; J. Sharif; Y. Xu; H. Ayame; H. Sugiyama; S. Iwai Analysis of distamycin A binding to UV-damaged DNA. Nucleic acids symposium series (2004),48,257-258 2004 英語
Y. Xu; H. Sugiyama; K. Tanaka; H. Osuga The recognition of Z-DNA by chiral helicene. Nucleic acids symposium series (2004),48,87-88 2004 英語
T. Fujiwara; H. Sugiyama; I. Hirao; S. Yokoyama Synthesis of 6-(2-thienyl)purine nucleoside derivatives toward the expansion of the genetic code. Nucleic acids symposium series,44,43-44 2000 英語
T. Bando; H. Iida; I. Saito; H. Sugiyama The synthesis of pyrrole(Py)/imidazole(Im) polyamide CPI conjugates which possess DNA interstrand cross-linking activity. Nucleic acids symposium series,44,45-46 2000 英語
K. Kino; H. Sugiyama GC-->CG transversion mutation might be caused by 8-oxoguanine oxidation product. Nucleic acids symposium series,44,139-140 2000 英語
S. Ikeda; I. Saito; H. Sugiyama Cleavage of parallel-stranded DNA duplex by peplomycin metal complexes. Nucleic acids symposium series,42,41-42 1999 英語
Y. Hiraku; S. Oikawa; S. Kawanishi; H. Sugiyama; I. Saito Amplification of bleomycin-induced DNA cleavage by pyrrole triamide. Nucleic acids symposium series,42,253-254 1999 英語
T. Oyoshi; H. Sugiyama; A.H. Wang Photoreactivity of 5-iodouracil-containing DNA-Sso7d complex. Nucleic acids symposium series,42,171-172 1999 英語
T. Fujiwara; Z.F. Tao; I. Saito; H. Sugiyama Synthesis of pyrrole-imidazole-duocarmycin polyamide and its sequence selective DNA alkylation. Nucleic acids symposium series,42,249-250 1999 英語
K. Kino; H. Sugiyama; I. Saito Analysis of guanine oxidation product via electron transfer in 5\\'-d(TTGGTA)-3\\'. Nucleic acids symposium series,37,39-40 1997 英語
T. Fujiwara; H. Sugiyama; I. Saito Structure of DNA containing aristeromycin analog. Nucleic acids symposium series,37,51-52 1997 英語
H. Sugiyama; C. Lian; M. Isomura; I. Saito; A.H.-J. Wang Distamycin A modulates the sequence specificity of DNA alkylation by duocarmycin A Proceedings of the National Academy of Sciences of the United States of America,93,25,14405-14410 1996 英語
M. Isomura; H. Sugiyama; I. Saito Efficient guanine alkylation through cooperative heterodimeric formation of duocarmycin A and distamycin A. Nucleic acids symposium series,34,47-48 1995 英語
K. Fujimoto; H. Sugiyama; I. Saito Photoreaction of 5-bromouracil-containing DNA. Nucleic acids symposium series,34,25-26 1995 英語
K. Kawai; H. Sugiyama; K. Fujimoto; I. Saito 8-Methylguanine-containing oligonucleotides: useful structural constraint for Z form DNA. Nucleic acids symposium series,34,33-34 1995 英語
I. Saito; M. Takayama; T. Nakamura; H. Sugiyama; Y. Komeda; M. Iwasaki The most electron-donating sites in duplex DNA: guanine-guanine stacking rule. Nucleic acids symposium series,34,191-192 1995 英語
Y. Komeda; K. Sakata; H. Sugiyama; I. Saito Synthesis of oligonucleotides containing a carbocyclic nucleoside. Nucleic acids symposium series,34,43-44 1995 英語
H. Sugiyama; K. Fujimoto; K. Hatano; K. Ohmori; I. Saito Chemistry of oxidative DNA strand scission. Nucleic acids symposium series,29,125-126 1993 英語
H. Sugiyama; E. Yamaguchi; K. Yamashita; K. Fujimoto; Y. Tsutsumi; I. Saito Photochemical deoxyribose C2\\' oxidation in 5-iodouracil-containing hexanucleotide. Nucleic acids symposium series,27,7-8 1992 英語
Kuniko Takemoto; Hiroshi Sugiyama; Osamu Nittono Current density dependence of microstructure and lattice expansion in porous silicon layers prepared by anodization Conference on Solid State Devices and Materials,252-254 1991 英語
H. Sugiyama; C.K. Lam; M. Hosoda; I. Saito Site specific covalent alkylation of DNA by antitumor antibiotics, duocarmycin A and kapurimycin A3. Nucleic acids symposium series,25,75-76 1991 英語
H. Sugiyama; T. Fujiwara; H. Kawabata; I. Saito; N. Hirayama; N. Yoda DNA strand scission by neocarzinostatin: molecular recognition process responsible for site-specificity. Nucleic acids symposium series,22,55-56 1990 英語
H. Sugiyama; H. Kawabata; T. Fujiwara; Y. Dannoue; T. Tashiro; T. Matsuura; I. Saito DNA strand scission by antitumor antibiotics. Detection of C-4\\'-hydroxylated abasic sites in DNA. Nucleic acids symposium series,21,51-52 1989 英語
H. Sugiyama; T. Morii; I. Saito; T. Matsuura; S.M. Hecht Structure and chemistry of alkali-labile product formed during Fe(II)-bleomycin-mediated DNA strand scission. Nucleic acids symposium series,17,165-166 1986 英語
I. Saito; H. Sugiyama; N. Furukawa; T. Matsuura Photoreaction of thymidine with primary amines. Application to specific modification of DNA. Nucleic acids symposium series,10,61-64 1981 英語

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外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
特定領域研究 DNA配列に基づくテーラーメード抗癌剤 2005〜2009
基盤研究(A) DNAの構造と反応性に関するケミカルバイオロジー研究 2007〜2010
特別研究員奨励費 代表 DNAオリガミを用いた生体分子ナノシステムの構築 2011〜2013
基盤研究(S) 代表 分子科学的アプローチによる遺伝子発現の制御と機構の解明 2012〜2016
基盤研究(S) 代表 分子科学的アプローチによる遺伝子発現の制御と機構の解明 2012/04/01〜2017/03/31
基盤研究(S) 代表 分子科学的アプローチによる遺伝子発現の制御と機構の解明 (平成26年度分) 2014/04/01〜2015/03/31
基盤研究(S) 代表 分子科学的アプローチによる遺伝子発現の制御と機構の解明 (平成27年度分) 2015/04/01〜2016/03/31
基盤研究(S) 代表 分子科学的アプローチによる遺伝子発現の制御と機構の解明 (平成27年度分) 2015/04/01〜2016/03/31
外部資金:競争的資金・科学研究費補助金以外
制度名 代表者名 研究課題(日本語) 研究課題(英語) 期間
国際共同研究事業国際化学研究協力事業 杉山 弘 完全長ヒトテロメア突出末端の構造のダイナミクスとサブドメインの安定性 (平成26年度分) 2014/04/01〜2015/03/31
国際共同研究事業国際化学研究協力事業 杉山 弘 完全長ヒトテロメア突出末端の構造のダイナミクスとサブドメインの安定性 (平成27年度分) 2015/04/01〜2016/03/31
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 期間
生物化学ゼミナールⅠA 前期 理学研究科 2011/04〜2012/03
生物化学ゼミナールⅠB 後期 理学研究科 2011/04〜2012/03
生物化学ゼミナールⅠC 前期 理学研究科 2011/04〜2012/03
生物化学ゼミナールⅠD 後期 理学研究科 2011/04〜2012/03
ケミカルバイオロジー概論 前期 理学研究科 2011/04〜2012/03
生物化学演習ⅠA 前期 理学研究科 2011/04〜2012/03
生物化学演習ⅠB 後期 理学研究科 2011/04〜2012/03
生物化学演習ⅠC 前期 理学研究科 2011/04〜2012/03
生物化学演習ⅠD 後期 理学研究科 2011/04〜2012/03
ケミカル・バイオロジー 前期 理学部 2011/04〜2012/03
現代化学入門A Introduction to Modern Chemistry 前期 全学共通科目 2011/04〜2012/03
化学課題研究16 通年 理学部 2011/04〜2012/03
ケミカル・バイオロジー Chemical Biology 前期 理学部 2012/04〜2013/03
化学課題研究16 Special study course II (Chemistry) 16 通年 理学部 2012/04〜2013/03
生物化学演習 Exercises in Biochemistry 後期 理学部 2012/04〜2013/03
細胞と物質をつなぐ科学 Integrated Cell-Material Sciences 後期 全学共通科目 2012/04〜2013/03
ケミカル・バイオロジー Chemical Biology 前期 理学部 2013/04〜2014/03
生物化学演習 Exercises in Biochemistry 後期 理学部 2013/04〜2014/03
化学課題研究16 Special study course II (Chemistry) 16 通年 理学部 2013/04〜2014/03
細胞と物質をつなぐ科学 Integrated Cell-Material Sciences 後期 全学共通科目 2013/04〜2014/03
ケミカル・バイオロジー Chemical Biology 前期 理学部 2014/04〜2015/03
生物化学演習 Exercises in Biochemistry 後期 理学部 2014/04〜2015/03
化学課題研究16 Special study course II (Chemistry) 16 通年 理学部 2014/04〜2015/03
ケミカルバイオロジー概論 Principles of Chemical Biology 前期 理学研究科 2014/04〜2015/03
生体分子機能論 Advanced Course in Molecular Biology and Biochemistry 後期 理学研究科 2014/04〜2015/03
生物化学ゼミナールIA Seminar on Biochemistry IA 前期 理学研究科 2014/04〜2015/03
生物化学ゼミナールIB Seminar on Biochemistry IB 後期 理学研究科 2014/04〜2015/03
生物化学ゼミナールIC Seminar on Biochemistry IC 前期 理学研究科 2014/04〜2015/03
生物化学ゼミナールID Seminar on Biochemistry ID 後期 理学研究科 2014/04〜2015/03
生物化学演習IA Advanced Biochemistry IA 前期 理学研究科 2014/04〜2015/03
生物化学演習IB Advanced Biochemistry IB 後期 理学研究科 2014/04〜2015/03
生物化学演習IC Advanced Biochemistry IC 前期 理学研究科 2014/04〜2015/03
生物化学演習ID Advanced Biochemistry ID 後期 理学研究科 2014/04〜2015/03
化学課題研究16 Special study course II (Chemistry) 16 通年 理学部 2015/04〜2016/03
ケミカルバイオロジー概論 Principles of Chemical Biology 前期 理学研究科 2015/04〜2016/03
生物化学II Biochemistry II 前期 理学部 2015/04〜2016/03
生物化学IV Biochemistry IV 前期 理学部 2015/04〜2016/03
生物化学ゼミナールIA Seminar on Biochemistry IA 前期 理学研究科 2015/04〜2016/03
生物化学ゼミナールIB Seminar on Biochemistry IB 後期 理学研究科 2015/04〜2016/03
生物化学ゼミナールIC Seminar on Biochemistry IC 前期 理学研究科 2015/04〜2016/03
生物化学ゼミナールID Seminar on Biochemistry ID 後期 理学研究科 2015/04〜2016/03
生物化学演習IA Advanced Biochemistry IA 前期 理学研究科 2015/04〜2016/03
生物化学演習IB Advanced Biochemistry IB 後期 理学研究科 2015/04〜2016/03
生物化学演習IC Advanced Biochemistry IC 前期 理学研究科 2015/04〜2016/03
生物化学演習ID Advanced Biochemistry ID 後期 理学研究科 2015/04〜2016/03
生物化学演習 Exercises in Biochemistry 後期 理学部 2015/04〜2016/03
化学課題研究16 Special study course II (Chemistry) 16 通年 理学部 2016/04〜2017/03
ケミカルバイオロジー概論 Principles of Chemical Biology 前期 理学研究科 2016/04〜2017/03
生体分子機能論 Advanced Course in Molecular Biology and Biochemistry 後期 理学研究科 2016/04〜2017/03
生物化学II Biochemistry II 前期 理学部 2016/04〜2017/03
生物化学IV Biochemistry IV 前期 理学部 2016/04〜2017/03
生物化学ゼミナールIA Seminar on Biochemistry IA 前期 理学研究科 2016/04〜2017/03
生物化学ゼミナールIB Seminar on Biochemistry IB 後期 理学研究科 2016/04〜2017/03
生物化学ゼミナールIC Seminar on Biochemistry IC 前期 理学研究科 2016/04〜2017/03
生物化学ゼミナールID Seminar on Biochemistry ID 後期 理学研究科 2016/04〜2017/03
生物化学演習IA Advanced Biochemistry IA 前期 理学研究科 2016/04〜2017/03
生物化学演習IB Advanced Biochemistry IB 後期 理学研究科 2016/04〜2017/03
生物化学演習IC Advanced Biochemistry IC 前期 理学研究科 2016/04〜2017/03
生物化学演習ID Advanced Biochemistry ID 後期 理学研究科 2016/04〜2017/03
生物化学演習 Exercises in Biochemistry 後期 理学部 2016/04〜2017/03

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部局運営(役職等)
役職名 期間
理学部・教育委員会委員 2016/04/01〜2017/03/31
理学部・教育委員会 少人数担任委員会委員 2016/04/01〜2017/03/31