小島 洋児

最終更新日時: 2019/01/11 11:22:15

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氏名(漢字/フリガナ/アルファベット表記)
小島 洋児/コジマ ヨウジ/Yoji Kojima
所属部署・職名(部局/所属/講座等/職名)
iPS細胞研究所/未来生命科学開拓部門/特定拠点助教
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
博士(医学) 京都大学
研究テーマ
(日本語)
生殖細胞の分化発生過程の解明
(英語)
Differentiation and development of germ cell lineage
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
多能性、幹細胞、胚発生 Pluripotency, Stem cells, Embryo development
生殖細胞 Germ cell
研究分野(科研費分類コード)
科研費分類コード
医化学一般
解剖学一般(含組織学・発生学)
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Yamashiro C, Sasaki K, Yabuta Y,_Kojima_Y, Nakamura T, Okamoto I, Yokobayashi S, Murase Y, Ishikura Y, Shirane K, Sasaki H, Yamamoto T,_Saitou_M. Yamashiro C, Sasaki K, Yabuta Y,_Kojima_Y, Nakamura T, Okamoto I, Yokobayashi S, Murase Y, Ishikura Y, Shirane K, Sasaki H, Yamamoto T,_Saitou_M. Yamashiro C, Sasaki K, Yabuta Y,_Kojima_Y, Nakamura T, Okamoto I, Yokobayashi S, Murase Y, Ishikura Y, Shirane K, Sasaki H, Yamamoto T,_Saitou_M. Generation of human oogonia from induced pluripotent stem cells in vitro. Generation of human oogonia from induced pluripotent stem cells in vitro. Generation of human oogonia from induced pluripotent stem cells in vitro. Science, 362, 6412, 356-360 Science, 362, 6412, 356-360 Science, 362, 6412, 356-360 2018/10/19 英語 公開
Kojima, Y., Sasaki, K., Yokobayashi, S., Sakai, Y., Nakamura, T., Yabuta, Y., Nakaki, F., Nagaoka, S., Woltjen, K., Hotta, A., Yamamoto, T., and Saitou, M. Kojima, Y., Sasaki, K., Yokobayashi, S., Sakai, Y., Nakamura, T., Yabuta, Y., Nakaki, F., Nagaoka, S., Woltjen, K., Hotta, A., Yamamoto, T., and Saitou, M. Kojima, Y., Sasaki, K., Yokobayashi, S., Sakai, Y., Nakamura, T., Yabuta, Y., Nakaki, F., Nagaoka, S., Woltjen, K., Hotta, A., Yamamoto, T., and Saitou, M. Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells. Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells. Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells. Cell stem cell, 21, 4, 517-532 Cell stem cell, 21, 4, 517-532 Cell Stem Cell, 21, 4, 517-532 2017/10/05 英語 公開
Kaufman-Francis K, Goh HN, Kojima Y, Studdert JB, Jones V, Power MD, Wilkie E, Teber E, Loebel DA, Tam PP Kaufman-Francis K, Goh HN, Kojima Y, Studdert JB, Jones V, Power MD, Wilkie E, Teber E, Loebel DA, Tam PP Kaufman-Francis K, Goh HN, Kojima Y, Studdert JB, Jones V, Power MD, Wilkie E, Teber E, Loebel DA, Tam PP Differential response of epiblast stem cells to Nodal and Activin signalling: a paradigm of early endoderm development in the embryo. Differential response of epiblast stem cells to Nodal and Activin signalling: a paradigm of early endoderm development in the embryo. Differential response of epiblast stem cells to Nodal and Activin signalling: a paradigm of early endoderm development in the embryo. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 369, 1657 Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 369, 1657 Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 369, 1657 2014/12 公開
Kojima Y, Tam OH, Tam PP Kojima Y, Tam OH, Tam PP Kojima Y, Tam OH, Tam PP Timing of developmental events in the early mouse embryo. Timing of developmental events in the early mouse embryo. Timing of developmental events in the early mouse embryo. Seminars in cell & developmental biology, 34, 65-75 Seminars in cell & developmental biology, 34, 65-75 Seminars in cell & developmental biology, 34, 65-75 2014/10 公開
Kojima Y, Kaufman-Francis K, Studdert JB, Steiner KA, Power MD, Loebel DA, Jones V, Hor A, de Alencastro G, Logan GJ, Teber ET, Tam OH, Stutz MD, Alexander IE, Pickett HA, Tam PP Kojima Y, Kaufman-Francis K, Studdert JB, Steiner KA, Power MD, Loebel DA, Jones V, Hor A, de Alencastro G, Logan GJ, Teber ET, Tam OH, Stutz MD, Alexander IE, Pickett HA, Tam PP Y. Kojima; K. Kaufman-Francis; J.B. Studdert; K.A. Steiner; M.D. Power; D.A.F. Loebel; V. Jones; A. Hor; G. De Alencastro; G.J. Logan; E.T. Teber; O.H. Tam; M.D. Stutz; I.E. Alexander; H.A. Pickett; P.P.L. Tam The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak. The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak. The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak Cell stem cell, 14, 1, 107-120 Cell stem cell, 14, 1, 107-120 Cell Stem Cell, 14, 1, 107-120 2014/01 英語 研究論文(学術雑誌) 公開
Tanaka SS, Kojima Y, Yamaguchi YL, Nishinakamura R, Tam PP Tanaka SS, Kojima Y, Yamaguchi YL, Nishinakamura R, Tam PP S.S. Tanaka; Y. Kojima; Y.L. Yamaguchi; R. Nishinakamura; P.P.L. Tam Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo. Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo. Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo Development, growth & differentiation, 53, 7, 843-856 Development, growth & differentiation, 53, 7, 843-856 Development Growth and Differentiation, 53, 7, 843-856 2011/09 英語 公開
Kuwabara Y, Ono K, Horie T, Nishi H, Nagao K, Kinoshita M, Watanabe S, Baba O, Kojima Y, Shizuta S, Imai M, Tamura T, Kita T, Kimura T Kuwabara Y, Ono K, Horie T, Nishi H, Nagao K, Kinoshita M, Watanabe S, Baba O, Kojima Y, Shizuta S, Imai M, Tamura T, Kita T, Kimura T Y. Kuwabara; K. Ono; T. Horie; H. Nishi; K. Nagao; M. Kinoshita; S. Watanabe; O. Baba; Y. Kojima; S. Shizuta; M. Imai; T. Tamura; T. Kita; T. Kimura Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage. Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage. Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage Circulation. Cardiovascular genetics, 4, 4, 446-454 Circulation. Cardiovascular genetics, 4, 4, 446-454 Circulation: Cardiovascular Genetics, 4, 4, 446-454 2011/08 英語 公開
Nakashima Y, Ono K, Yoshida Y, Kojima Y, Kita T, Tanaka M, Kimura T Nakashima Y, Ono K, Yoshida Y, Kojima Y, Kita T, Tanaka M, Kimura T Y. Nakashima; K. Ono; Y. Yoshida; Y. Kojima; T. Kita; M. Tanaka; T. Kimura The search for Nkx2-5-regulated genes using purified embryonic stem cell-derived cardiomyocytes with Nkx2-5 gene targeting. The search for Nkx2-5-regulated genes using purified embryonic stem cell-derived cardiomyocytes with Nkx2-5 gene targeting. The search for Nkx2-5-regulated genes using purified embryonic stem cell-derived cardiomyocytes with Nkx2-5 gene targeting Biochemical and biophysical research communications, 390, 3, 821-826 Biochemical and biophysical research communications, 390, 3, 821-826 Biochemical and Biophysical Research Communications, 390, 3, 821-826 2009/12 英語 公開
Kojima Y, Ono K, Inoue K, Takagi Y, Kikuta K, Nishimura M, Yoshida Y, Nakashima Y, Matsumae H, Furukawa Y, Mikuni N, Nobuyoshi M, Kimura T, Kita T, Tanaka M Kojima Y, Ono K, Inoue K, Takagi Y, Kikuta K, Nishimura M, Yoshida Y, Nakashima Y, Matsumae H, Furukawa Y, Mikuni N, Nobuyoshi M, Kimura T, Kita T, Tanaka M Y. Kojima; K. Ono; K. Inoue; Y. Takagi; K.-i. Kikuta; M. Nishimura; Y. Yoshida; Y. Nakashima; H. Matsumae; Y. Furukawa; N. Mikuni; M. Nobuyoshi; T. Kimura; T. Kita; M. Tanaka Progranulin expression in advanced human atherosclerotic plaque. Progranulin expression in advanced human atherosclerotic plaque. Progranulin expression in advanced human atherosclerotic plaque Atherosclerosis, 206, 1, 102-108 Atherosclerosis, 206, 1, 102-108 Atherosclerosis, 206, 1, 102-108 2009/09 英語 公開
Matsumae H, Yoshida Y, Ono K, Togi K, Inoue K, Furukawa Y, Nakashima Y, Kojima Y, Nobuyoshi M, Kita T, Tanaka M Matsumae H, Yoshida Y, Ono K, Togi K, Inoue K, Furukawa Y, Nakashima Y, Kojima Y, Nobuyoshi M, Kita T, Tanaka M H. Matsumae; Y. Yoshida; K. Ono; K. Togi; K. Inoue; Y. Furukawa; Y. Nakashima; Y. Kojima; M. Nobuyoshi; T. Kita; M. Tanaka CCN1 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model. CCN1 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model. CCN1 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model Arteriosclerosis, thrombosis, and vascular biology, 28, 6, 1077-1083 Arteriosclerosis, thrombosis, and vascular biology, 28, 6, 1077-1083 Arteriosclerosis, Thrombosis, and Vascular Biology, 28, 6, 1077-1083 2008/06 英語 公開
Yoshida Y, Togi K, Matsumae H, Nakashima Y, Kojima Y, Yamamoto H, Ono K, Nakamura T, Kita T, Tanaka M Yoshida Y, Togi K, Matsumae H, Nakashima Y, Kojima Y, Yamamoto H, Ono K, Nakamura T, Kita T, Tanaka M Y. Yoshida; K. Togi; H. Matsumae; Y. Nakashima; Y. Kojima; H. Yamamoto; K. Ono; T. Nakamura; T. Kita; M. Tanaka CCN1 protects cardiac myocytes from oxidative stress via beta1 integrin-Akt pathway. CCN1 protects cardiac myocytes from oxidative stress via beta1 integrin-Akt pathway. CCN1 protects cardiac myocytes from oxidative stress via β1 integrin-Akt pathway Biochemical and biophysical research communications, 355, 3, 611-618 Biochemical and biophysical research communications, 355, 3, 611-618 Biochemical and Biophysical Research Communications, 355, 3, 611-618 2007/04 英語 公開
K. Nagao; K. Ono; Y. Iwanaga; Y. Tamaki; Y. Kojima; T. Horie; H. Nishi; M. Kinoshita; Y. Kuwabara; K. Hasegawa; T. Kita; T. Kimura K. Nagao; K. Ono; Y. Iwanaga; Y. Tamaki; Y. Kojima; T. Horie; H. Nishi; M. Kinoshita; Y. Kuwabara; K. Hasegawa; T. Kita; T. Kimura Neural cell adhesion molecule is a cardioprotective factor up-regulated by metabolic stress Neural cell adhesion molecule is a cardioprotective factor up-regulated by metabolic stress Journal of Molecular and Cellular Cardiology, 48, 6, 1157-1168 , 48, 6, 1157-1168 Journal of Molecular and Cellular Cardiology, 48, 6, 1157-1168 2010/06 英語 公開
S. Takenaka; K. Mitsudo; K. Inoue; T. Goto; K. Kadota; S. Fujii; H. Yamamoto; Y. Fuku; A. Hirono; H. Tanaka; M. Taba; A. Ikeda; Y. Kojima; J. Maekawa; S. Maekawa; N. Takahashi; H. Saeki; Y. Nakamura; T. Oonishi; N. Ueda S. Takenaka; K. Mitsudo; K. Inoue; T. Goto; K. Kadota; S. Fujii; H. Yamamoto; Y. Fuku; A. Hirono; H. Tanaka; M. Taba; A. Ikeda; Y. Kojima; J. Maekawa; S. Maekawa; N. Takahashi; H. Saeki; Y. Nakamura; T. Oonishi; N. Ueda Successful treatment of primary cardiac lymphoma with atrioventricular nodal block Successful treatment of primary cardiac lymphoma with atrioventricular nodal block International Heart Journal, 46, 5, 927-931 , 46, 5, 927-931 International Heart Journal, 46, 5, 927-931 2005 英語 公開

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タイトル言語:
Misc
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
小島 洋児 小島 洋児 Yoji Kojima ヒト特異的な始原生殖細胞の運命決定機構 ヒト特異的な始原生殖細胞の運命決定機構 Human Specific Molecular Mechanisms of Primordial Germ Cell Differentiation 第39回日本分子生物学会年会 第39回日本分子生物学会年会 The 39th Annual Meeting of the Molecular Biology Society of Japan 2016/12 日本語 公開
Kojima Y, Studdert JB, Steiner KA, Kaufman-Francis K, Power MD, Loebel DAF, Tam PPL Kojima Y, Studdert JB, Steiner KA, Kaufman-Francis K, Power MD, Loebel DAF, Tam PPL Characteristics of multipotent stem cells derived from epiblast and ectoderm of post-implantation mouse embryos Characteristics of multipotent stem cells derived from epiblast and ectoderm of post-implantation mouse embryos 10th Annual Meeitng for International Society of Stem Cell Research 10th Annual Meeitng for International Society of Stem Cell Research 2012/06 英語 公開
Kojima Y, Studdert JB, Steiner KA, Power MD, Loebel DAF, Tam PPL Kojima Y, Studdert JB, Steiner KA, Power MD, Loebel DAF, Tam PPL Characterization of mouse epiblast stem cells derived from gastrula-stage embryos Characterization of mouse epiblast stem cells derived from gastrula-stage embryos 第44回 日本発生生物学会年次総会 第44回 日本発生生物学会年次総会 2011/05 英語 公開
KOJIMA Yoji;ONO Koh;INOUE Katsumi;YOSHIDA Yoshinori;NAKASHIMA Yasuhiro;NOBUYOSHI Masakiyo;KITA Toru;KIMURA Takeshi;TANAKA Makoto KOJIMA Yoji;ONO Koh;INOUE Katsumi;YOSHIDA Yoshinori;NAKASHIMA Yasuhiro;NOBUYOSHI Masakiyo;KITA Toru;KIMURA Takeshi;TANAKA Makoto Progranulin is Expressed in the Human Atherosclerotic Plaque and Reduces IL-8 Secretion from Smooth Muscle Cells, Endothelial Cells, And Macrophages Progranulin is Expressed in the Human Atherosclerotic Plaque and Reduces IL-8 Secretion from Smooth Muscle Cells, Endothelial Cells, And Macrophages Circ J, 74, Supplement 1, 466 , 74, Supplement 1, 466 Circ J, 74, Supplement 1, 466 2010/03/01 英語 公開
小島洋児、尾野亘、井上勝美、高木康志、菊田健一郎、西村真樹、吉田善紀、中島康弘、松前宏信、古川裕、三國信啓、延吉正清、木村剛、北徹、田中誠 小島洋児、尾野亘、井上勝美、高木康志、菊田健一郎、西村真樹、吉田善紀、中島康弘、松前宏信、古川裕、三國信啓、延吉正清、木村剛、北徹、田中誠 Progranulin Expression in Advanced Human Atherosclerotic Plaque Progranulin Expression in Advanced Human Atherosclerotic Plaque 第73回 日本循環器学会 年次総会 第73回 日本循環器学会 年次総会 2009/03/23 英語 公開
タイトル言語:
講演・口頭発表等
タイトル タイトル(日本語) タイトル(英語) 会議名 会議名(日本語) 会議名(英語) 主催者 主催者(日本語) 主催者(英語) 開催年月日 記述言語 会議種別 公開
Evolutionarily Distinctive Mechanisms of Human Germ Cell Lineage Specification Evolutionarily Distinctive Mechanisms of Human Germ Cell Lineage Specification Evolutionarily Distinctive Mechanisms of Human Germ Cell Lineage Specification Annual Meeting of International Society for Stem Cell Research Annual Meeting of International Society for Stem Cell Research Annual Meeting of International Society for Stem Cell Research International Society for Stem Cell Research International Society for Stem Cell Research International Society for Stem Cell Research 2018/06/22 英語 口頭発表(一般) 公開
Human Specific Molecular Mechanisms of Primordial Germ Cell Differentiation Human Specific Molecular Mechanisms of Primordial Germ Cell Differentiation Human Specific Molecular Mechanisms of Primordial Germ Cell Differentiation 日本分子生物学会年会 日本分子生物学会年会 Annual Meeting of the Molecular Biology Society of Japan 日本分子生物学会 日本分子生物学会 Molecular Biology Society of Japan 2016/12/01 日本語 口頭発表(一般) 公開
Characterisation of Epiblast Stem Cells (EpiSC) – Tool to understand gastrulation. Characterisation of Epiblast Stem Cells (EpiSC) – Tool to understand gastrulation. CMRI seminar CMRI seminar CMRI, Australia CMRI, Australia 2012/06/29 英語 口頭発表(招待・特別) 公開
Characteristics of multipotent stem cells derived from the epiblast and ectoderm of post implantation mouse embryos Characteristics of multipotent stem cells derived from the epiblast and ectoderm of post implantation mouse embryos Characteristics of multipotent stem cells derived from the epiblast and ectoderm of post implantation mouse embryos Annual Meeting of International Society for Stem Cell Research Annual Meeting of International Society for Stem Cell Research Annual Meeting of International Society for Stem Cell Research International Society for Stem Cell Research International Society for Stem Cell Research International Society for Stem Cell Research 2012/06/15 英語 ポスター発表 公開
Characteristics of multipotent stem cells derived from the epiblast and ectoderm of post implantation mouse embryos Characteristics of multipotent stem cells derived from the epiblast and ectoderm of post implantation mouse embryos Characteristics of multipotent stem cells derived from the epiblast and ectoderm of post implantation mouse embryos 日本発生生物学会年会 日本発生生物学会年会 Japanese Society of Developmental Biologists 46th and Japan Society for Cell Biology 日本発生生物学会年会 日本発生生物学会年会 Japanese Society of Developmental Biologists 46th and Japan Society for Cell Biology 2012/05/31 英語 ポスター発表 公開
Pluripotency in epiblasts and stem cells. Pluripotency in epiblasts and stem cells. 15th NSW Stem Cell Workshop 15th NSW Stem Cell Workshop NSW Stem Cell Network, Australia NSW Stem Cell Network, Australia 2011/08/31 英語 口頭発表(招待・特別) 公開
タイトル言語:
外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
基盤研究(C) 代表 ヒトES/iPS細胞の多能性維持におけるPRDM14の作用機序の解明 (平成27年度分) 2015/04/01〜2016/03/31
基盤研究(C) 代表 ヒトES/iPS細胞の多能性維持におけるPRDM14の作用機序の解明 (平成28年度分) 2016/04/01〜2017/03/31
基盤研究(C) 代表 ヒトES/iPS細胞の多能性維持におけるPRDM14の作用機序の解明 (平成29年度分) 2017/04/01〜2018/03/31
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
細胞と物質をつなぐ科学 Integrated Cell-Material Sciences 後期 全学共通科目 2015/04〜2016/03