本庶 佑

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氏名(漢字/フリガナ/アルファベット表記)
本庶 佑/ホンジョ タスク/Honjo, Tasuku
所属部署・職名(部局/所属/講座等/職名)
高等研究院//特別教授
学内兼務
部局 所属 講座等 職名
医学研究科 免疫ゲノム医学講座 特任教授
所属学会(国内)
学会名(日本語) 学会名(英語)
日本免疾学会 Japanese Society for Immunology
日本分子生物学会 The Molecular Biology Society of Japan
日本生化学会 The Japnese Biochemical Society
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
医学博士 京都大学
職歴
期間 組織名(日本語) 組織名(英語) 職名(日本語) 職名(英語)
1971〜1973 米国カーネギー研究所  Carnegie Institution of Washington 客員研究員 Fellow
1973〜1974 米国NIH(NICHD)  NIH(NICHP) 客員研究員 Visiting Fellow and Associate
1974〜1979 東京大学医学部 University Tokyo 助手 Assistant Professor
1979〜1984 大阪大学医学部 Osaka University 教授 Professor
1984〜 京都大学医学部 Kyoto University 教授 Professor
researchmap URL
https://researchmap.jp/read0012306
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
本庶 佑 本庶 佑 本庶 佑 Uracil DNA glycosylase activity is dispensable for immunogloblin class switch Uracil DNA glycosylase activity is dispensable for immunogloblin class switch Uracil DNA glycosylase activity is dispensable for immunogloblin class switch Science,305/, 1160-1163 Science,305/, 1160-1163 Science,305/, 1160-1163 2004 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Constitutive expression of AID leads to tumorigenesis Constitutive expression of AID leads to tumorigenesis Constitutive expression of AID leads to tumorigenesis J.Exp.Med,197/, 1173-1181 J.Exp.Med,197/, 1173-1181 J.Exp.Med,197/, 1173-1181 2003 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 AID enzyme - induced hypermutation in an actively transcribed gene in fibroblasts. AID enzyme - induced hypermutation in an actively transcribed gene in fibroblasts. AID enzyme - induced hypermutation in an actively transcribed gene in fibroblasts. Science,296/, 2033-2036 Science,296/, 2033-2036 Science,296/, 2033-2036 2002 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 The AID enzyme induces class switch recombination in fibtoblasts The AID enzyme induces class switch recombination in fibtoblasts The AID enzyme induces class switch recombination in fibtoblasts Nature,416/, 340-345 Nature,416/, 340-345 Nature,416/, 340-345 2002 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Autoimmune dialatod cardiomyopathy in PD-1 receptor-deficient mice Autoimmune dialatod cardiomyopathy in PD-1 receptor-deficient mice Autoimmune dialatod cardiomyopathy in PD-1 receptor-deficient mice Science,291/,319-322 Science,291/,319-322 Science,291/,319-322 2001 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2) Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2) Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2) Cell,102/5,565-575 Cell,102/5,565-575 Cell,102/5,565-575 2000 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Class swith recombination and somatic hypermutation require activation-induced cytidin deaminase (AID), a potential RNA editing enzyme Class swith recombination and somatic hypermutation require activation-induced cytidin deaminase (AID), a potential RNA editing enzyme Class swith recombination and somatic hypermutation require activation-induced cytidin deaminase (AID), a potential RNA editing enzyme Cell,102/5,553-563 Cell,102/5,553-563 Cell,102/5,553-563 2000 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Conservation of the notch signalling pathway in mammalian Neurogenesis. Conservation of the notch signalling pathway in mammalian Neurogenesis. Conservation of the notch signalling pathway in mammalian Neurogenesis. Development,124/,1139 Development,124/,1139 Development,124/,1139 1997 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice. Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice. Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice. J. Exp. Med.,185/,791 J. Exp. Med.,185/,791 J. Exp. Med.,185/,791 1997 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. Development,124/,4133 Development,124/,4133 Development,124/,4133 1997 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 In vitro development of primitive and definitive erythrocyte from different precursors. In vitro development of primitive and definitive erythrocyte from different precursors. In vitro development of primitive and definitive erythrocyte from different precursors. Science,272/,722 Science,272/,722 Science,272/,722 1996 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 The shortest path from the surface to the nucleus : RBPJk/Su(H) transcription factor. The shortest path from the surface to the nucleus : RBPJk/Su(H) transcription factor. The shortest path from the surface to the nucleus : RBPJk/Su(H) transcription factor. Genes to Cells,1/,1 Genes to Cells,1/,1 Genes to Cells,1/,1 1996 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Disruption of the mouse RBP-Jk gene results in early embryonic death. Disruption of the mouse RBP-Jk gene results in early embryonic death. Disruption of the mouse RBP-Jk gene results in early embryonic death. Development,121/,3291 Development,121/,3291 Development,121/,3291 1995 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Physical interaction of a novel domain of the mouse notch receptor with the RBP-Jk transcription factor. Physical interaction of a novel domain of the mouse notch receptor with the RBP-Jk transcription factor. Physical interaction of a novel domain of the mouse notch receptor with the RBP-Jk transcription factor. Current Biology,5/,1416 Current Biology,5/,1416 Current Biology,5/,1416 1995 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Antigen-receptor cross-linking induces neritoneal B cell apoptosis in normal but notautoimmunity-prone mice. Antigen-receptor cross-linking induces neritoneal B cell apoptosis in normal but notautoimmunity-prone mice. Antigen-receptor cross-linking induces neritoneal B cell apoptosis in normal but notautoimmunity-prone mice. Current biology,4,8-17 Current biology,4,8-17 Current biology,4,8-17 1994 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-Jk, the homologue of Drosophila Suppressor of Hairless. Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-Jk, the homologue of Drosophila Suppressor of Hairless. Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-Jk, the homologue of Drosophila Suppressor of Hairless. EMBO. J.,13/,4973-4982 EMBO. J.,13/,4973-4982 EMBO. J.,13/,4973-4982 1994 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Generation of lymphohematopoietic cells from embryonic stem cells in culture. Generation of lymphohematopoietic cells from embryonic stem cells in culture. Generation of lymphohematopoietic cells from embryonic stem cells in culture. Science,265/,1098-1101 Science,265/,1098-1101 Science,265/,1098-1101 1994 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse. Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse. Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse. J. Exp. Med.,180/,111-121 J. Exp. Med.,180/,111-121 J. Exp. Med.,180/,111-121 1994 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 B cell apoptosis induced by antigen receptor crosslinking is blocked by T cell signal through CD40. B cell apoptosis induced by antigen receptor crosslinking is blocked by T cell signal through CD40. B cell apoptosis induced by antigen receptor crosslinking is blocked by T cell signal through CD40. Nature,364,645-648 Nature,364,645-648 Nature,364,645-648 1993 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Signal sequence trap : cloning strategy for secreted proteins and type I membrane proteins. Signal sequence trap : cloning strategy for secreted proteins and type I membrane proteins. Signal sequence trap : cloning strategy for secreted proteins and type I membrane proteins. Science,261,600-603 Science,261,600-603 Science,261,600-603 1993 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy chain locus. Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy chain locus. Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy chain locus. nature genetics,3,88-94 nature genetics,3,88-94 nature genetics,3,88-94 1993 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow. The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow. The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow. J. Exp. Med.,178,1247-1254 J. Exp. Med.,178,1247-1254 J. Exp. Med.,178,1247-1254 1993 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Antigen-induced apoptotic of Ly-1 B cells responsible for autoimmune disease in transgenic mice Antigen-induced apoptotic of Ly-1 B cells responsible for autoimmune disease in transgenic mice Antigen-induced apoptotic of Ly-1 B cells responsible for autoimmune disease in transgenic mice Nature 357,77-80,357 Nature 357,77-80,357 Nature 357,77-80,357 1992 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the intergrase motif A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the intergrase motif A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the intergrase motif Nature 342,934-937,342 Nature 342,934-937,342 Nature 342,934-937,342 1989 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Cloning of cDNA encoding the murine igG1 induction factor by a novel strategy using SP6 promoter. Cloning of cDNA encoding the murine igG1 induction factor by a novel strategy using SP6 promoter. Cloning of cDNA encoding the murine igG1 induction factor by a novel strategy using SP6 promoter. Nature,319/,640 Nature,319/,640 Nature,319/,640 1986 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Cloning of complementary DNA encoding T-cell replacing factor and identify with B-cell growth factor 11 Cloning of complementary DNA encoding T-cell replacing factor and identify with B-cell growth factor 11 Cloning of complementary DNA encoding T-cell replacing factor and identify with B-cell growth factor 11 Nature 324,70-73,324 Nature 324,70-73,324 Nature 324,70-73,324 1986 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Immunogloblin class switching Immunogloblin class switching Immunogloblin class switching Cell 36,801-803,36 Cell 36,801-803,36 Cell 36,801-803,36 1984 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Molecular cloning of cDNA encoding human interleukin-2 receptor Molecular cloning of cDNA encoding human interleukin-2 receptor Molecular cloning of cDNA encoding human interleukin-2 receptor Nature 311,631-635,311 Nature 311,631-635,311 Nature 311,631-635,311 1984 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Immunoglobulin genes. Immunoglobulin genes. Immunoglobulin genes. Ann. Rev. Immunol.,1/,499 Ann. Rev. Immunol.,1/,499 Ann. Rev. Immunol.,1/,499 1983 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Switch region of the immunoglobulin Cugeneis composed of simple trandem repetitive sequences Switch region of the immunoglobulin Cugeneis composed of simple trandem repetitive sequences Switch region of the immunoglobulin Cugeneis composed of simple trandem repetitive sequences Nature 292,845-848,292 Nature 292,845-848,292 Nature 292,845-848,292 1981 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Cloning immunoglobulin r2b chain gene of mouse : characterization and partial sequence determination Cloning immunoglobulin r2b chain gene of mouse : characterization and partial sequence determination Cloning immunoglobulin r2b chain gene of mouse : characterization and partial sequence determination Cell 18,559-568,18 Cell 18,559-568,18 Cell 18,559-568,18 1979 英語 研究論文(学術雑誌) 公開
本庶 佑 本庶 佑 本庶 佑 Organization of immnoglobulin heavy chain genes and allelic deletion model Organization of immnoglobulin heavy chain genes and allelic deletion model Organization of immnoglobulin heavy chain genes and allelic deletion model Proceeding of National Academy of Science 75,2140-2144,75 Proceeding of National Academy of Science 75,2140-2144,75 Proceeding of National Academy of Science 75,2140-2144,75 1978 英語 研究論文(学術雑誌) 公開

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著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Uracil DNA glycosylase activity is dispensable for immunogloblin class switch Uracil DNA glycosylase activity is dispensable for immunogloblin class switch Science, 305, 5687, 1160-1163 , 305, 5687, 1160-1163 Science, 305, 5687, 1160-1163 2004 公開
Constitutive expression of AID leads to tumorigenesis Constitutive expression of AID leads to tumorigenesis J.Exp.Med, 197, 1173-1181 , 197, 1173-1181 J.Exp.Med, 197, 1173-1181 2003 公開
The AID enzyme induces class switch recombination in fibtoblasts The AID enzyme induces class switch recombination in fibtoblasts Nature, 416, 6878, 340-345 , 416, 6878, 340-345 Nature, 416, 6878, 340-345 2002 公開
AID enzyme - induced hypermutation in an actively transcribed gene in fibroblasts. AID enzyme - induced hypermutation in an actively transcribed gene in fibroblasts. Science, 296, 5575, 2033-2036 , 296, 5575, 2033-2036 Science, 296, 5575, 2033-2036 2002 公開
Autoimmune dialatod cardiomyopathy in PD-1 receptor-deficient mice Autoimmune dialatod cardiomyopathy in PD-1 receptor-deficient mice Science, 291, 5502, 319-322 , 291, 5502, 319-322 Science, 291, 5502, 319-322 2001 公開
Class swith recombination and somatic hypermutation require activation-induced cytidin deaminase (AID), a potential RNA editing enzyme Class swith recombination and somatic hypermutation require activation-induced cytidin deaminase (AID), a potential RNA editing enzyme Cell, 102, 5, 553-563 , 102, 5, 553-563 Cell, 102, 5, 553-563 2000 公開
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2) Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2) Cell, 102, 5, 565-575 , 102, 5, 565-575 Cell, 102, 5, 565-575 2000 公開
Alymphoplasia(aly) is caused by a point mutation in the mouse NF-kB inducing kinase gene. (共著) Alymphoplasia(aly) is caused by a point mutation in the mouse NF-kB inducing kinase gene. (共著) Nature Genet., 22, 1, 74-77 , 22, 1, 74-77 Nature Genet., 22, 1, 74-77 1999 公開
Notch-signalling controls pancreatic cell differentiation. (共著) Notch-signalling controls pancreatic cell differentiation. (共著) Nature, 400, 6747, 877-881 , 400, 6747, 877-881 Nature, 400, 6747, 877-881 1999 公開
Development of lups-like autoimmune disease by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor : implication for brekdown of peripheral tolerance. (共著) Development of lups-like autoimmune disease by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor : implication for brekdown of peripheral tolerance. (共著) Immunity, 11, 141-151 , 11, 141-151 Immunity, 11, 141-151 1999 公開
Molecular mechanism of immunoglobulin class switch recombination. (共著) Molecular mechanism of immunoglobulin class switch recombination. (共著) Cold Spring Harber Sympo. Quant. Biol., 64 , 64 Cold Spring Harber Sympo. Quant. Biol., 64 1999 公開
The complete nucleotide sequence of the human immunoglobulin heavy-chain variable region locus. (共著) The complete nucleotide sequence of the human immunoglobulin heavy-chain variable region locus. (共著) J. Exp. Med., 188, 11, 2151-2162 , 188, 11, 2151-2162 J. Exp. Med., 188, 11, 2151-2162 1998 公開
Target specifity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions. (共著) Target specifity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions. (共著) Immunity, 9, 849-858 , 9, 849-858 Immunity, 9, 849-858 1998 公開
Frequent but biased class switch recombination in the Sm flanking regions. (共著) Frequent but biased class switch recombination in the Sm flanking regions. (共著) Curr. Biol., 8, 4, 227-230 , 8, 4, 227-230 Curr. Biol., 8, 4, 227-230 1998 公開
Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. (共著) Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. (共著) Science, 279, 5349, 389-393 , 279, 5349, 389-393 Science, 279, 5349, 389-393 1998 公開
Conservation of the notch signalling pathway in mammalian Neurogenesis. Conservation of the notch signalling pathway in mammalian Neurogenesis. Development, 124, 1139 , 124, 1139 Development, 124, 1139 1997 公開
Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice. Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice. J. Exp. Med., 185, 4, 791-794 , 185, 4, 791-794 J. Exp. Med., 185, 4, 791-794 1997 公開
Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. Development, 124, 4133 , 124, 4133 Development, 124, 4133 1997 公開
The shortest path from the surface to the nucleus : RBPJk/Su(H) transcription factor. The shortest path from the surface to the nucleus : RBPJk/Su(H) transcription factor. Genes to Cells, 1, 1 , 1, 1 Genes to Cells, 1, 1 1996 公開
In vitro development of primitive and definitive erythrocyte from different precursors. In vitro development of primitive and definitive erythrocyte from different precursors. Science, 272, 5262, 722-724 , 272, 5262, 722-724 Science, 272, 5262, 722-724 1996 公開
Disruption of the mouse RBP-Jk gene results in early embryonic death. Disruption of the mouse RBP-Jk gene results in early embryonic death. Development, 121, 3291 , 121, 3291 Development, 121, 3291 1995 公開
Physical interaction of a novel domain of the mouse notch receptor with the RBP-Jk transcription factor. Physical interaction of a novel domain of the mouse notch receptor with the RBP-Jk transcription factor. Current Biology, 5, 1416 , 5, 1416 Current Biology, 5, 1416 1995 公開
Antigen-receptor cross-linking induces neritoneal B cell apoptosis in normal but notautoimmunity-prone mice. Antigen-receptor cross-linking induces neritoneal B cell apoptosis in normal but notautoimmunity-prone mice. Current biology, 4,8-17/, , 4,8-17/, Current biology, 4,8-17/, 1994 公開
Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse. Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse. J. Exp. Med., 180, 1, 111-121 , 180, 1, 111-121 J. Exp. Med., 180, 1, 111-121 1994 公開
Generation of lymphohematopoietic cells from embryonic stem cells in culture. Generation of lymphohematopoietic cells from embryonic stem cells in culture. Science, 265, 5175, 1098-1101 , 265, 5175, 1098-1101 Science, 265, 5175, 1098-1101 1994 公開
Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-Jk, the homologue of Drosophila Suppressor of Hairless. Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-Jk, the homologue of Drosophila Suppressor of Hairless. EMBO. J., 13, 4973-4982 , 13, 4973-4982 EMBO. J., 13, 4973-4982 1994 公開
B cell apoptosis induced by antigen receptor crosslinking is blocked by T cell signal through CD40. B cell apoptosis induced by antigen receptor crosslinking is blocked by T cell signal through CD40. Nature, 364,645-648/, , 364,645-648/, Nature, 364,645-648/, 1993 公開
Signal sequence trap : cloning strategy for secreted proteins and type I membrane proteins. Signal sequence trap : cloning strategy for secreted proteins and type I membrane proteins. Science, 261,600-603/, , 261,600-603/, Science, 261,600-603/, 1993 公開
Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy chain locus. Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy chain locus. nature genetics, 3,88-94/, , 3,88-94/, nature genetics, 3,88-94/, 1993 公開
The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow. The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow. J. Exp. Med., 178,1247-1254/, , 178,1247-1254/, J. Exp. Med., 178,1247-1254/, 1993 公開
Antigen-induced apoptotic of Ly-1 B cells responsible for autoimmune disease in transgenic mice Antigen-induced apoptotic of Ly-1 B cells responsible for autoimmune disease in transgenic mice Nature 357,77-80, 357 , 357 Nature 357,77-80, 357 1992 公開
The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development. (共著) The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development. (共著) Cell, 69, 7, 1191-1197 , 69, 7, 1191-1197 Cell, 69, 7, 1191-1197 1992 公開
Circular DNA is excised by immunoglobulin class switch recombimation. Circular DNA is excised by immunoglobulin class switch recombimation. Cell, 62, 1, 143-149 , 62, 1, 143-149 Cell, 62, 1, 143-149 1990 公開
A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the intergrase motif A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the intergrase motif Nature 342,934-937, 342 , 342 Nature 342,934-937, 342 1989 公開
Interleukin la mRNA virus-transformed T and B cells Interleukin la mRNA virus-transformed T and B cells Biochemical Biophysical Research Communication 139,353-360, 139 , 139 Biochemical Biophysical Research Communication 139,353-360, 139 1986 公開
Cloning of complementary DNA encoding T-cell replacing factor and identify with B-cell growth factor 11 Cloning of complementary DNA encoding T-cell replacing factor and identify with B-cell growth factor 11 Nature 324,70-73, 324 , 324 Nature 324,70-73, 324 1986 公開
Cloning of cDNA encoding the murine igG1 induction factor by a novel strategy using SP6 promoter. Cloning of cDNA encoding the murine igG1 induction factor by a novel strategy using SP6 promoter. Nature, 319, 6055, 640-646 , 319, 6055, 640-646 Nature, 319, 6055, 640-646 1986 公開
Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. (共著) Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. (共著) Nature, 319, 6055, 640-646 , 319, 6055, 640-646 Nature, 319, 6055, 640-646 1986 公開
Immunogloblin class switching Immunogloblin class switching Cell 36,801-803, 36 , 36 Cell 36,801-803, 36 1984 公開
Molecular cloning of cDNA encoding human interleukin-2 receptor Molecular cloning of cDNA encoding human interleukin-2 receptor Nature 311,631-635, 311 , 311 Nature 311,631-635, 311 1984 公開
Immunoglobulin genes. Immunoglobulin genes. Ann. Rev. Immunol., 1, 499-528 , 1, 499-528 Ann. Rev. Immunol., 1, 499-528 1983 公開
Organization of the constant-region gene family of the mouse immunoglobulin heavy chain. (共著) Organization of the constant-region gene family of the mouse immunoglobulin heavy chain. (共著) Cell, 28, 3, 499-506 , 28, 3, 499-506 Cell, 28, 3, 499-506 1982 公開
Ordering of mouse immunoglobulin heavy chain genes by molecular cloning Ordering of mouse immunoglobulin heavy chain genes by molecular cloning Nature 289,149-153, 289 , 289 Nature 289,149-153, 289 1981 公開
Switch region of the immunoglobulin Cugeneis composed of simple trandem repetitive sequences Switch region of the immunoglobulin Cugeneis composed of simple trandem repetitive sequences Nature 292,845-848, 292 , 292 Nature 292,845-848, 292 1981 公開
Cloning immunoglobulin r2b chain gene of mouse : characterization and partial sequence determination Cloning immunoglobulin r2b chain gene of mouse : characterization and partial sequence determination Cell 18,559-568, 18 , 18 Cell 18,559-568, 18 1979 公開
Organization of immnoglobulin heavy chain genes and allelic deletion model Organization of immnoglobulin heavy chain genes and allelic deletion model Proceeding of National Academy of Science 75,2140-2144, 75 , 75 Proceeding of National Academy of Science 75,2140-2144, 75 1978 公開

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タイトル言語:
学術賞等
賞の名称(日本語) 賞の名称(英語) 授与組織名(日本語) 授与組織名(英語) 年月
日本生化学会奨励賞 1978
野口英世記念医学賞 1981
朝日賞 1982
大阪科学賞 1984
木原賞 1984
ベルツ賞 1985
米国免疾学学会名誉会員 1988
武田医学賞 1988
Fogarty Scholar-in resideme at NIH 1991
ベーリング北里賞 1992
上原賞 1994
恩賜賞学士院賞 1996
文化功労者 2000
米国アカデミー外国人会賞 2001
ドイツ自然科学者アカデミー・レオゴルディナ会員 2003

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外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
特別推進研究 AIDによるtopoisomerase1を介したゲノム不安定性誘導のメカニズム 2010〜2014
特別推進研究 ΑΙDによる抗原刺激依存性抗体遺伝子改編機構の研究 2005〜2009
特別推進研究 代表 AIDによる抗原刺激依存性抗体遺伝子改編機構の研究
特別研究員奨励費 代表
特別研究員奨励費 代表 AIDによる発癌機構の解析とAID阻害剤の探索
特別推進研究 代表 AIDによるtopoisomeraselを介したゲノム不安定性誘導のメカニズム 2010〜2014
特別推進研究 代表 AIDによるtopoisomeraselを介したゲノム不安定性誘導のメカニズム 2010〜2014
特別推進研究 代表 AIDによるtopoisomeraselを介したゲノム不安定性誘導のメカニズム (平成26年度分) 2014/04/01〜2015/03/31
基盤研究(S) 代表 AIDのRNA編集機構による抗体の多様化とゲノム不安定化の制御機構 (平成27年度分) 2015/04/01〜2016/03/31
特別推進研究 代表 AIDによるtopoisomerase1を介したゲノム不安定性誘導のメカニズム (平成27年度分) 2015/04/01〜2016/03/31
特別研究員奨励費 代表 メタボリズム制御によるPD-1阻害がん免疫治療の増強効果 (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(S) 代表 AIDのRNA編集機構による抗体の多様化とゲノム不安定化の制御機構 (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(S) 代表 AIDのRNA編集機構による抗体の多様化とゲノム不安定化の制御機構 (平成30年度分) 2018/04/01〜2019/03/31
特別研究員奨励費 代表 メタボリズム制御によるPD-1阻害がん免疫治療の増強効果 (平成30年度分) 2018/04/01〜2019/03/31

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外部資金:競争的資金・科学研究費補助金以外
制度名 代表者名 研究課題(日本語) 研究課題(英語) 期間
自己免疫病の制御機構 Reglation of autoimmccne diseases
細胞分化の機構 Molecular mechanism of cell differentiation
免疫グロブリンクラススイッチと体細胞突然変異の分子機構 Molecular mechanism of immunoglobulin class switching and somatic hypermutation
部局運営(役職等)
役職名 期間
高等研究院 副院長 2018/04/01〜2020/03/31