大串 雅俊

最終更新日時: 2019/06/13 11:28:34

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氏名(漢字/フリガナ/アルファベット表記)
大串 雅俊/オオグシ マサトシ/Ohgushi, Masatoshi
所属部署・職名(部局/所属/講座等/職名)
ウイルス・再生医科学研究所/生命システム研究部門/准教授
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士(生命科学) 京都大学
博士(生命科学) 京都大学
ORCID ID
https://orcid.org/0000-0002-1293-4893
researchmap URL
https://researchmap.jp/read0110981
研究テーマ
(日本語)
ヒト多能性幹細胞の性状解析と応用
(英語)
Characterization and application of of human pluripotent stem cells
研究概要
(日本語)
ヒトES/iPS細胞は生体を構成するあらゆる細胞へ分化するポテンシャルを有した多能性幹細胞であり、その特性から医療・産業的に有用な細胞材料のリソースとして期待されている。これらヒト多能性幹細胞の有用性をさらに拡大させるため、より詳細な性状解析、分化特性検討などに取り組んでいる。
(英語)
Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, hold hold huge potential as reproductive resources for cell-therapies as well as for drug discovery. In order to further expand thier applications, we are working on detailed analyses of pluripotency and differentiation potency of human pluripotent stem cells.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
ヒト多能性幹細胞 human embryonic stem cells
細胞分化 differentiation
初期発生 development
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Ohgushi Masatoshi Ohgushi Masatoshi OGUSHI Masatoshi A Practical Protocol for the Conditional Depletion of Rho Isoforms in Human Embryonic Stem Cells. A Practical Protocol for the Conditional Depletion of Rho Isoforms in Human Embryonic Stem Cells. A Practical Protocol for the Conditional Depletion of Rho Isoforms in Human Embryonic Stem Cells. Methods in Molecular Biology, 1821, 283-295 Methods in Molecular Biology, 1821, 283-295 Methods in Molecular Biology, 1821, 283-295 2018/07 英語 研究論文(学術雑誌) 公開
Ohgushi M, Minaguchi M, Eiraku M, Sasai Y Ohgushi M, Minaguchi M, Eiraku M, Sasai Y Ohgushi M, Minaguchi M, Eiraku M, Sasai Y A RHO Small GTPase Regulator ABR Secures Mitotic Fidelity in Human Embryonic Stem Cells. A RHO Small GTPase Regulator ABR Secures Mitotic Fidelity in Human Embryonic Stem Cells. A RHO Small GTPase Regulator ABR Secures Mitotic Fidelity in Human Embryonic Stem Cells. Stem cell reports, 9, 1, 58-66 Stem cell reports, 9, 1, 58-66 Stem cell reports, 9, 1, 58-66 2017/07 公開
Sakaguchi H, Kadoshima T, Soen M, Narii N, Ishida Y, Ohgushi M, Takahashi J, Eiraku M, Sasai Y Sakaguchi H, Kadoshima T, Soen M, Narii N, Ishida Y, Ohgushi M, Takahashi J, Eiraku M, Sasai Y Sakaguchi H, Kadoshima T, Soen M, Narii N, Ishida Y, Ohgushi M, Takahashi J, Eiraku M, Sasai Y Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue. Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue. Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue. Nature communications, 6, 8896 Nature communications, 6, 8896 Nature communications, 6, 8896 2015/11 公開
Ohgushi M, Minaguchi M, Sasai Y Ohgushi M, Minaguchi M, Sasai Y Ohgushi M, Minaguchi M, Sasai Y Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells. Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells. Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells. Cell stem cell, 17, 4, 448-461 Cell stem cell, 17, 4, 448-461 Cell stem cell, 17, 4, 448-461 2015/10 公開
Fukusumi H, Shofuda T, Kanematsu D, Yamamoto A, Suemizu H, Nakamura M, Yamasaki M, Ohgushi M, Sasai Y, Kanemura Y Fukusumi H, Shofuda T, Kanematsu D, Yamamoto A, Suemizu H, Nakamura M, Yamasaki M, Ohgushi M, Sasai Y, Kanemura Y Fukusumi H, Shofuda T, Kanematsu D, Yamamoto A, Suemizu H, Nakamura M, Yamasaki M, Ohgushi M, Sasai Y, Kanemura Y Feeder-free generation and long-term culture of human induced pluripotent stem cells using pericellular matrix of decidua derived mesenchymal cells. Feeder-free generation and long-term culture of human induced pluripotent stem cells using pericellular matrix of decidua derived mesenchymal cells. Feeder-free generation and long-term culture of human induced pluripotent stem cells using pericellular matrix of decidua derived mesenchymal cells. PloS one, 8, 1, e55226 PloS one, 8, 1, e55226 PloS one, 8, 1, e55226 2013 公開
Suga H, Kadoshima T, Minaguchi M, Ohgushi M, Soen M, Nakano T, Takata N, Wataya T, Muguruma K, Miyoshi H, Yonemura S, Oiso Y, Sasai Y Suga H, Kadoshima T, Minaguchi M, Ohgushi M, Soen M, Nakano T, Takata N, Wataya T, Muguruma K, Miyoshi H, Yonemura S, Oiso Y, Sasai Y Suga H, Kadoshima T, Minaguchi M, Ohgushi M, Soen M, Nakano T, Takata N, Wataya T, Muguruma K, Miyoshi H, Yonemura S, Oiso Y, Sasai Y Self-formation of functional adenohypophysis in three-dimensional culture. Self-formation of functional adenohypophysis in three-dimensional culture. Self-formation of functional adenohypophysis in three-dimensional culture. Nature, 480, 7375, 57-62 Nature, 480, 7375, 57-62 Nature, 480, 7375, 57-62 2011/11 公開
Ohgushi M, Sasai Y Ohgushi M, Sasai Y Ohgushi M, Sasai Y Lonely death dance of human pluripotent stem cells: ROCKing between metastable cell states. Lonely death dance of human pluripotent stem cells: ROCKing between metastable cell states. Lonely death dance of human pluripotent stem cells: ROCKing between metastable cell states. Trends in cell biology, 21, 5, 274-282 Trends in cell biology, 21, 5, 274-282 Trends in cell biology, 21, 5, 274-282 2011/05 公開
Kamiya D, Banno S, Sasai N, Ohgushi M, Inomata H, Watanabe K, Kawada M, Yakura R, Kiyonari H, Nakao K, Jakt LM, Nishikawa S, Sasai Y Kamiya D, Banno S, Sasai N, Ohgushi M, Inomata H, Watanabe K, Kawada M, Yakura R, Kiyonari H, Nakao K, Jakt LM, Nishikawa S, Sasai Y Kamiya D, Banno S, Sasai N, Ohgushi M, Inomata H, Watanabe K, Kawada M, Yakura R, Kiyonari H, Nakao K, Jakt LM, Nishikawa S, Sasai Y Intrinsic transition of embryonic stem-cell differentiation into neural progenitors. Intrinsic transition of embryonic stem-cell differentiation into neural progenitors. Intrinsic transition of embryonic stem-cell differentiation into neural progenitors. Nature, 470, 7335, 503-509 Nature, 470, 7335, 503-509 Nature, 470, 7335, 503-509 2011/02 公開
Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A, Muguruma K, Nakano T, Suga H, Ueno M, Ishizaki T, Suemori H, Narumiya S, Niwa H, Sasai Y Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A, Muguruma K, Nakano T, Suga H, Ueno M, Ishizaki T, Suemori H, Narumiya S, Niwa H, Sasai Y Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A, Muguruma K, Nakano T, Suga H, Ueno M, Ishizaki T, Suemori H, Narumiya S, Niwa H, Sasai Y Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. Cell stem cell, 7, 2, 225-239 Cell stem cell, 7, 2, 225-239 Cell stem cell, 7, 2, 225-239 2010/08 公開
Nagase T, Ueno M, Matsumura M, Muguruma K, Ohgushi M, Kondo N, Kanematsu D, Kanemura Y, Sasai Y Nagase T, Ueno M, Matsumura M, Muguruma K, Ohgushi M, Kondo N, Kanematsu D, Kanemura Y, Sasai Y Nagase T, Ueno M, Matsumura M, Muguruma K, Ohgushi M, Kondo N, Kanematsu D, Kanemura Y, Sasai Y Pericellular matrix of decidua-derived mesenchymal cells: a potent human-derived substrate for the maintenance culture of human ES cells. Pericellular matrix of decidua-derived mesenchymal cells: a potent human-derived substrate for the maintenance culture of human ES cells. Pericellular matrix of decidua-derived mesenchymal cells: a potent human-derived substrate for the maintenance culture of human ES cells. Developmental dynamics : an official publication of the American Association of Anatomists, 238, 5, 1118-1130 Developmental dynamics : an official publication of the American Association of Anatomists, 238, 5, 1118-1130 Developmental dynamics : an official publication of the American Association of Anatomists, 238, 5, 1118-1130 2009/05 公開
Sasai Y, Ogushi M, Nagase T, Ando S Sasai Y, Ogushi M, Nagase T, Ando S Sasai Y, Ogushi M, Nagase T, Ando S Bridging the gap from frog research to human therapy: a tale of neural differentiation in Xenopus animal caps and human pluripotent cells. Bridging the gap from frog research to human therapy: a tale of neural differentiation in Xenopus animal caps and human pluripotent cells. Bridging the gap from frog research to human therapy: a tale of neural differentiation in Xenopus animal caps and human pluripotent cells. Development, growth & differentiation, 50 Suppl 1, S47-55 Development, growth & differentiation, 50 Suppl 1, S47-55 Development, growth & differentiation, 50 Suppl 1, S47-55 2008/06 公開
Ohgushi M, Kuroki S, Fukamachi H, O'Reilly LA, Kuida K, Strasser A, Yonehara S Ohgushi M, Kuroki S, Fukamachi H, O'Reilly LA, Kuida K, Strasser A, Yonehara S Ohgushi M, Kuroki S, Fukamachi H, O'Reilly LA, Kuida K, Strasser A, Yonehara S Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells. Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells. Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells. Molecular and cellular biology, 25, 22, 10017-10028 Molecular and cellular biology, 25, 22, 10017-10028 Molecular and cellular biology, 25, 22, 10017-10028 2005/11 公開
Imai T, Adachi S, Nishijo K, Ohgushi M, Okada M, Yasumi T, Watanabe K, Nishikomori R, Nakayama T, Yonehara S, Toguchida J, Nakahata T Imai T, Adachi S, Nishijo K, Ohgushi M, Okada M, Yasumi T, Watanabe K, Nishikomori R, Nakayama T, Yonehara S, Toguchida J, Nakahata T Imai T, Adachi S, Nishijo K, Ohgushi M, Okada M, Yasumi T, Watanabe K, Nishikomori R, Nakayama T, Yonehara S, Toguchida J, Nakahata T FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. Oncogene, 22, 58, 9231-9242 Oncogene, 22, 58, 9231-9242 Oncogene, 22, 58, 9231-9242 2003/12 公開

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タイトル言語:
外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
基盤研究C 代表 ヒト多能性幹細胞維持における細胞間コミュニケーションの役割と新規情報伝達機構解析 (平成29年度分) 2017/04/01〜2018/03/31
基盤研究(C) 代表 ヒト多能性幹細胞維持における細胞間コミュニケーションの役割と新規情報伝達機構解析 (平成30年度分) 2018/04/01〜2019/03/31
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
化学生物学 Chemical Biology 後期 工学部 2018/04〜2019/03
生命医科学 Life and Medical Sciences 前期 工学研究科 2018/04〜2019/03
生命医科学特論 Life and Medical Sciences, Adv. 前期 工学研究科 2018/04〜2019/03
化学生物学 Chemical Biology 後期 工学部 2019/04〜2020/03
生命医科学 Life and Medical Sciences 前期 工学研究科 2019/04〜2020/03
生命医科学特論 Life and Medical Sciences, Adv. 前期 工学研究科 2019/04〜2020/03